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Aliases for SULT1A2 Gene

Aliases for SULT1A2 Gene

  • Sulfotransferase Family 1A Member 2 2 3 5
  • Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 2 2 3
  • Phenol-Sulfating Phenol Sulfotransferase 2 3 4
  • Phenol Sulfotransferase 2 3 4
  • Aryl Sulfotransferase 2 3 4
  • EC 2.8.2.1 4 63
  • P-PST 2 3 4
  • ST1A2 3 4
  • STP2 3 4
  • Phenol-Preferring Phenol Sulfotransferase2 3
  • Phenolic-Metabolizing (P) Form Of PST 3
  • Thermostable Phenol Sulfotransferase 3
  • Arylamine Sulfotransferase 3
  • EC 2.8.2 63
  • TSPST2 3
  • P-PST 3
  • HAST4 3

External Ids for SULT1A2 Gene

Previous HGNC Symbols for SULT1A2 Gene

  • STP2

Previous GeneCards Identifiers for SULT1A2 Gene

  • GC16M028947
  • GC16P028687
  • GC16P028432
  • GC16P028496
  • GC16P028470
  • GC16M028510
  • GC16M028603
  • GC16M026628

Summaries for SULT1A2 Gene

Entrez Gene Summary for SULT1A2 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT1A2 Gene

SULT1A2 (Sulfotransferase Family 1A Member 2) is a Protein Coding gene. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include sulfotransferase activity and flavonol 3-sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT1A2 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Gene Wiki entry for SULT1A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1A2 Gene

Genomics for SULT1A2 Gene

Regulatory Elements for SULT1A2 Gene

Promoters for SULT1A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SULT1A2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SULT1A2 gene promoter:

Genomic Location for SULT1A2 Gene

Chromosome:
16
Start:
28,591,943 bp from pter
End:
28,597,109 bp from pter
Size:
5,167 bases
Orientation:
Minus strand

Genomic View for SULT1A2 Gene

Genes around SULT1A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1A2 Gene

Proteins for SULT1A2 Gene

  • Protein details for SULT1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50226-ST1A2_HUMAN
    Recommended name:
    Sulfotransferase 1A2
    Protein Accession:
    P50226
    Secondary Accessions:
    • A9QY25
    • P78393
    • Q14CJ7

    Protein attributes for SULT1A2 Gene

    Size:
    295 amino acids
    Molecular mass:
    34310 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SULT1A2 Gene

neXtProt entry for SULT1A2 Gene

Proteomics data for SULT1A2 Gene at MOPED

Post-translational modifications for SULT1A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT1A2 Gene

Domains & Families for SULT1A2 Gene

Gene Families for SULT1A2 Gene

Protein Domains for SULT1A2 Gene

Suggested Antigen Peptide Sequences for SULT1A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50226

UniProtKB/Swiss-Prot:

ST1A2_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1A2: view

Function for SULT1A2 Gene

Molecular function for SULT1A2 Gene

GENATLAS Biochemistry:
aryl (phenol) sulfotransferase 2,phenol preferring,cytosolic
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + a phenol = adenosine 3,5-bisphosphate + an aryl sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Enzyme Numbers (IUBMB) for SULT1A2 Gene

genes like me logo Genes that share phenotypes with SULT1A2: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SULT1A2 Gene

Localization for SULT1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1A2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT1A2 Gene COMPARTMENTS Subcellular localization image for SULT1A2 gene
Compartment Confidence
cytosol 5
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for SULT1A2 Gene

Pathways & Interactions for SULT1A2 Gene

genes like me logo Genes that share pathways with SULT1A2: view

Pathways by source for SULT1A2 Gene

Interacting Proteins for SULT1A2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000338742%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000386394%0d%0a9606.ENSP00000367207%0d%0a
Selected Interacting proteins: ENSP00000338742 P50226-ST1A2_HUMAN for SULT1A2 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SULT1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process IDA,TAS 20417180
GO:0008202 steroid metabolic process IEA --
GO:0044281 small molecule metabolic process TAS --
GO:0051923 sulfation IDA 20056724
genes like me logo Genes that share ontologies with SULT1A2: view

No data available for SIGNOR curated interactions for SULT1A2 Gene

Drugs & Compounds for SULT1A2 Gene

(3) Drugs for SULT1A2 Gene - From: PharmGKB, Novoseek, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenol Approved, Experimental Pharma 43
Conjugated Estrogens Approved Pharma 0

(5) Additional Compounds for SULT1A2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phenol sulphate
  • Aryl sulfate
  • Aryl sulphate
  • phenyl hydrogen sulfate
  • phenyl hydrogen sulphate
  • phenylsulfate
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with SULT1A2: view

Transcripts for SULT1A2 Gene

Unigene Clusters for SULT1A2 Gene

Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -
SP3: - - - - - - - -
SP4: - - - - -
SP5:

Relevant External Links for SULT1A2 Gene

GeneLoc Exon Structure for
SULT1A2
ECgene alternative splicing isoforms for
SULT1A2

Expression for SULT1A2 Gene

mRNA expression in normal human tissues for SULT1A2 Gene

mRNA differential expression in normal tissues according to GTEx for SULT1A2 Gene

This gene is overexpressed in Liver (x11.2), Small Intestine - Terminal Ileum (x8.0), and Colon - Transverse (x4.6).

Protein differential expression in normal tissues from HIPED for SULT1A2 Gene

This gene is overexpressed in Heart (34.8), Liver (18.1), and Skin (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SULT1A2 Gene



SOURCE GeneReport for Unigene cluster for SULT1A2 Gene Hs.546304

genes like me logo Genes that share expression patterns with SULT1A2: view

Protein tissue co-expression partners for SULT1A2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SULT1A2 Gene

Orthologs for SULT1A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT1A2 35
  • 98.53 (n)
  • 97.97 (a)
SULT1A2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SULT1A1 36
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SULT1A1 36
  • 85 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sult1a1 36
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG16733 37
  • 28 (a)
CG5428 37
  • 33 (a)
Species with no ortholog for SULT1A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SULT1A2 Gene

ENSEMBL:
Gene Tree for SULT1A2 (if available)
TreeFam:
Gene Tree for SULT1A2 (if available)

Paralogs for SULT1A2 Gene

genes like me logo Genes that share paralogs with SULT1A2: view

Variants for SULT1A2 Gene

Sequence variations from dbSNP and Humsavar for SULT1A2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_007426 -
VAR_007427 -
VAR_057340 -
VAR_057341 -
VAR_057342 -

Structural Variations from Database of Genomic Variants (DGV) for SULT1A2 Gene

Variant ID Type Subtype PubMed ID
dgv842e1 CNV Complex 17122850
dgv843e1 CNV Complex 17122850
nsv509608 CNV Insertion 20534489
nsv905689 CNV Loss 21882294
nsv833182 CNV Gain 17160897
nsv905690 CNV Gain 21882294
dgv2664n71 CNV Gain 21882294
nsv905694 CNV Loss 21882294
nsv9416 CNV Gain+Loss 18304495
dgv12n14 CNV Loss 18776910
nsv1775 CNV Insertion 18451855
esv2667967 CNV Deletion 23128226
nsv436734 CNV Insertion 17901297
esv2714170 CNV Deletion 23290073

Variation tolerance for SULT1A2 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.14; 90.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SULT1A2 Gene

HapMap Linkage Disequilibrium report
SULT1A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1A2 Gene

Disorders for SULT1A2 Gene

Relevant External Links for SULT1A2

Genetic Association Database (GAD)
SULT1A2
Human Genome Epidemiology (HuGE) Navigator
SULT1A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SULT1A2

No disorders were found for SULT1A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SULT1A2 Gene

Publications for SULT1A2 Gene

  1. Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization. (PMID: 8661000) Her C. … Weinshilboum R.M. (Genomics 1996) 2 3 4 23 67
  2. Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16. (PMID: 8912648) Dooley T.P. … Huang Z. (Biochem. Biophys. Res. Commun. 1996) 2 3 23
  3. A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. (PMID: 12419832) Sachse C. … Wolf C.R. (Carcinogenesis 2002) 3 23
  4. Cloning, structural organization, and chromosomal mapping of the human phenol sulfotransferase STP2 gene. (PMID: 9119390) Gaedigk A. … Grant D.M. (Genomics 1997) 3 23
  5. cDNA cloning and expression of a new form of human aryl sulfotransferase. (PMID: 8697101) Zhu X. … McManus M.E. (Int. J. Biochem. Cell Biol. 1996) 3 23

Products for SULT1A2 Gene

Sources for SULT1A2 Gene

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