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Aliases for SULT1A2 Gene

Aliases for SULT1A2 Gene

  • Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 2 2 3
  • STP2 3 4 6
  • Phenol-Sulfating Phenol Sulfotransferase 2 3 4
  • Phenol Sulfotransferase 2 3 4
  • Aryl Sulfotransferase 2 3 4
  • EC 2.8.2.1 4 63
  • P-PST 2 3 4
  • ST1A2 3 4
  • Phenol-Preferring Phenol Sulfotransferase2 3
  • Phenolic-Metabolizing (P) Form Of PST 3
  • Thermostable Phenol Sulfotransferase 3
  • Arylamine Sulfotransferase 3
  • Sulfotransferase 1A2 3
  • EC 2.8.2 63
  • TSPST2 3
  • HAST4 3
  • P-PST 3

External Ids for SULT1A2 Gene

Previous HGNC Symbols for SULT1A2 Gene

  • STP2

Previous GeneCards Identifiers for SULT1A2 Gene

  • GC16M028947
  • GC16P028687
  • GC16P028432
  • GC16P028496
  • GC16P028470
  • GC16M028510
  • GC16M028603
  • GC16M026628

Summaries for SULT1A2 Gene

Entrez Gene Summary for SULT1A2 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT1A2 Gene

SULT1A2 (Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 2) is a Protein Coding gene. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include sulfotransferase activity and flavonol 3-sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT1A2 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk

Gene Wiki entry for SULT1A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1A2 Gene

Genomics for SULT1A2 Gene

Regulatory Elements for SULT1A2 Gene

Transcription factor binding sites by QIAGEN in the SULT1A2 gene promoter:

Genomic Location for SULT1A2 Gene

Start:
28,591,943 bp from pter
End:
28,597,109 bp from pter
Size:
5,167 bases
Orientation:
Minus strand

Genomic View for SULT1A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SULT1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1A2 Gene

Proteins for SULT1A2 Gene

  • Protein details for SULT1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50226-ST1A2_HUMAN
    Recommended name:
    Sulfotransferase 1A2
    Protein Accession:
    P50226
    Secondary Accessions:
    • A9QY25
    • P78393
    • Q14CJ7

    Protein attributes for SULT1A2 Gene

    Size:
    295 amino acids
    Molecular mass:
    34310 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SULT1A2 Gene

neXtProt entry for SULT1A2 Gene

Proteomics data for SULT1A2 Gene at MOPED

Post-translational modifications for SULT1A2 Gene

  • Ubiquitination at Lys106
  • Modification sites at PhosphoSitePlus

Other Protein References for SULT1A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for SULT1A2 Gene

Gene Families for SULT1A2 Gene

HGNC:
  • SULT :Sulfotransferases, cytosolic

Protein Domains for SULT1A2 Gene

Suggested Antigen Peptide Sequences for SULT1A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50226

UniProtKB/Swiss-Prot:

ST1A2_HUMAN :
  • P50226
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1A2: view

Function for SULT1A2 Gene

Molecular function for SULT1A2 Gene

GENATLAS Biochemistry: aryl (phenol) sulfotransferase 2,phenol preferring,cytosolic
UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + a phenol = adenosine 3,5-bisphosphate + an aryl sulfate.
UniProtKB/Swiss-Prot Function: Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk

Enzyme Numbers (IUBMB) for SULT1A2 Gene

Gene Ontology (GO) - Molecular Function for SULT1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity IDA 20417180
GO:0005515 protein binding IPI 25416956
GO:0008146 sulfotransferase activity TAS 9119390
GO:0047894 flavonol 3-sulfotransferase activity IDA 20056724
genes like me logo Genes that share ontologies with SULT1A2: view

Phenotypes for SULT1A2 Gene

GenomeRNAi human phenotypes for SULT1A2:
genes like me logo Genes that share phenotypes with SULT1A2: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SULT1A2 Gene

Localization for SULT1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1A2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT1A2 Gene COMPARTMENTS Subcellular localization image for SULT1A2 gene
Compartment Confidence
cytosol 4
nucleus 1

Gene Ontology (GO) - Cellular Components for SULT1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT1A2: view

Pathways for SULT1A2 Gene

genes like me logo Genes that share pathways with SULT1A2: view

Pathways by source for SULT1A2 Gene

Interacting Proteins for SULT1A2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000338742%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000386394%0d%0a9606.ENSP00000367207%0d%0a
Selected Interacting proteins: ENSP00000338742 P50226-ST1A2_HUMAN for SULT1A2 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SULT1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006584 catecholamine metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process --
GO:0008202 steroid metabolic process IEA --
GO:0009309 amine biosynthetic process TAS 9119390
genes like me logo Genes that share ontologies with SULT1A2: view

Compounds for SULT1A2 Gene

(3) HMDB Compounds for SULT1A2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Phenol
  • acide carbolique
108-95-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
482-67-7

(4) Novoseek inferred chemical compound relationships for SULT1A2 Gene

Compound -log(P) Hits PubMed IDs
p-nitrophenol 73.2 2
phenol 72.4 8
3-phosphoadenosine 5-phosphosulfate 67.8 2
epoxide 45.2 1

(1) PharmGKB related drug/compound annotations for SULT1A2 Gene

Drug/compound Annotation
conjugated estrogens CA
genes like me logo Genes that share compounds with SULT1A2: view

Transcripts for SULT1A2 Gene

Unigene Clusters for SULT1A2 Gene

Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -
SP3: - - - - - - - -
SP4: - - - - -
SP5:

Relevant External Links for SULT1A2 Gene

GeneLoc Exon Structure for
SULT1A2
ECgene alternative splicing isoforms for
SULT1A2

Expression for SULT1A2 Gene

mRNA expression in normal human tissues for SULT1A2 Gene

mRNA differential expression in normal tissues according to GTEx for SULT1A2 Gene

This gene is overexpressed in Liver (11.2), Small Intestine - Terminal Ileum (8.0), and Colon - Transverse (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SULT1A2 Gene

SOURCE GeneReport for Unigene cluster for SULT1A2 Gene Hs.546304

genes like me logo Genes that share expressions with SULT1A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SULT1A2 Gene

Orthologs for SULT1A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT1A2 35
  • 98.53 (n)
  • 97.97 (a)
SULT1A2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SULT1A1 36
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SULT1A1 36
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sult1a1 36
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5428 37
  • 33 (a)
CG16733 37
  • 28 (a)
Species with no ortholog for SULT1A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SULT1A2 Gene

ENSEMBL:
Gene Tree for SULT1A2 (if available)
TreeFam:
Gene Tree for SULT1A2 (if available)

Paralogs for SULT1A2 Gene

Selected SIMAP similar genes for SULT1A2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SULT1A2: view

Variants for SULT1A2 Gene

Sequence variations from dbSNP and Humsavar for SULT1A2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs193652 -- 28,596,296(-) GCAGG(A/G)AGACA intron-variant, utr-variant-5-prime
rs193653 -- 28,593,215(-) GACAC(C/T)TGGGG intron-variant
rs193654 -- 28,593,128(-) CCATC(C/T)TGACT intron-variant
rs743590 -- 28,596,909(-) CTATC(C/T)CTGCC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs762632 -- 28,596,368(-) TCGGG(A/G)AGAGG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SULT1A2 Gene

Variant ID Type Subtype PubMed ID
dgv842e1 CNV Complex 17122850
dgv843e1 CNV Complex 17122850
nsv509608 CNV Insertion 20534489
nsv905689 CNV Loss 21882294
nsv833182 CNV Gain 17160897
nsv905690 CNV Gain 21882294
dgv2664n71 CNV Gain 21882294
nsv905694 CNV Loss 21882294
nsv9416 CNV Gain+Loss 18304495
dgv12n14 CNV Loss 18776910
nsv1775 CNV Insertion 18451855
esv2667967 CNV Deletion 23128226
nsv436734 CNV Insertion 17901297
esv2714170 CNV Deletion 23290073

Relevant External Links for SULT1A2 Gene

HapMap Linkage Disequilibrium report
SULT1A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1A2 Gene

Disorders for SULT1A2 Gene

(2) Novoseek inferred disease relationships for SULT1A2 Gene

Disease -log(P) Hits PubMed IDs
colorectal cancer 8.74 1
breast cancer 4.36 2

Relevant External Links for SULT1A2

Genetic Association Database (GAD)
SULT1A2
Human Genome Epidemiology (HuGE) Navigator
SULT1A2
genes like me logo Genes that share disorders with SULT1A2: view

No data available for UniProtKB/Swiss-Prot for SULT1A2 Gene

Publications for SULT1A2 Gene

  1. Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization. (PMID: 8661000) Her C. … Weinshilboum R.M. (Genomics 1996) 2 3 4 23
  2. Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16. (PMID: 8912648) Dooley T.P. … Huang Z. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23
  3. cDNA cloning and expression of a new form of human aryl sulfotransferase. (PMID: 8697101) Zhu X. … McManus M.E. (Int. J. Biochem. Cell Biol. 1996) 3 4 23
  4. Cloning, structural organization, and chromosomal mapping of the human phenol sulfotransferase STP2 gene. (PMID: 9119390) Gaedigk A. … Grant D.M. (Genomics 1997) 3 4 23
  5. A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. (PMID: 12419832) Sachse C. … Wolf C.R. (Carcinogenesis 2002) 3 23 48

Products for SULT1A2 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SULT1A2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SULT1A2
    • Block miRNA regulation of SULT1A2 using miScript Target Protectors

    Sources for SULT1A2 Gene

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