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SULT1A1 Gene

protein-coding   GIFtS: 68
GCID: GC16M028616

Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring,...


(Previous symbols: STP, STP1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 11 2     PST2 5
STP1 2 3 5     P-PST2
STP11 2 3 5     TSPST12
Aryl Sulfotransferase 12 3     Sulfotransferase 1A12
Phenol-Sulfating Phenol Sulfotransferase 12 3     Thermostable Phenol Sulfotransferase12
HAST1/HAST22 3     ts-PST2
ST1A12 3     Ts-PST3
ST1A32 3     Phenol Sulfotransferase 13
P-PST 12 3     Thermostable Phenol Sulfotransferase3
EC 2.8.2.13 8     EC 2.8.28

External Ids:    HGNC: 114531   Entrez Gene: 68172   Ensembl: ENSG000001965027   OMIM: 1711505   UniProtKB: P502253   

Export aliases for SULT1A1 gene to outside databases

Previous GC identifers: GC16M028946 GC16P028674 GC16P028431 GC16P028469 GC16M028524 GC16M026642


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SULT1A1 Gene:
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and
xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate
specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes
one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants
that encode two isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SULT1A1 Gene:
SULT1A1 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1) is a protein-coding gene. Diseases associated with SULT1A1 include batten disease, and familial breast cancer. GO annotations related to this gene include sulfotransferase activity and flavonol 3-sulfotransferase activity. An important paralog of this gene is SULT1C3.

UniProtKB/Swiss-Prot: ST1A1_HUMAN, P50225
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase
activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of
carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer
risk

Gene Wiki entry for SULT1A1 Gene

PharmGKB "VIP" summary for SULT1A1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SULT1A1 gene promoter:
         STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSULT1A1 promoter sequence
   Search Chromatin IP Primers for SULT1A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SULT1A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.1   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p12.1

SULT1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT1A1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M028616:  view genomic region     (about GC identifiers)

Start:
28,616,903 bp from pter      End:
28,634,946 bp from pter
Size:
18,044 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ST1A1_HUMAN, P50225 (See protein sequence)
Recommended Name: Sulfotransferase 1A1  
Size: 295 amino acids; 34165 Da
Subunit: Homodimer
Selected PDB 3D structures from and Proteopedia for SULT1A1 (see all 11):
1LS6 (3D)        1Z28 (3D)        2D06 (3D)        3QVU (3D)        3QVV (3D)        3U3J (3D)    
Secondary accessions: Q2NL71 Q86U58 Q92818 Q9BVU6 Q9UGG7
Alternative splicing: 2 isoforms:  P50225-1   P50225-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SULT1A1: NX_P50225

Explore proteomics data for SULT1A1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys106
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SULT1A1 (P50225) (see all 14)
     LYLFYED  FTVAQNE  VSYYHFY  SPFMRKG 


    See SULT1A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001046.2  NP_803565.1  NP_803566.1  NP_803878.1  NP_803880.1  

    ENSEMBL proteins: 
     ENSP00000329399   ENSP00000454388   ENSP00000456215   ENSP00000457912   ENSP00000321988  
     ENSP00000457083   ENSP00000456459   ENSP00000455979   ENSP00000378972   ENSP00000378971  
    Reactome Protein details: P50225

    SULT1A1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULT: Sulfotransferases, cytosolic

    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry P50225

    ProtoNet protein and cluster: P50225

    1 Blocks protein domain: IPB000863 Sulfotransferase

    UniProtKB/Swiss-Prot: ST1A1_HUMAN, P50225
    Similarity: Belongs to the sulfotransferase 1 family


    SULT1A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST1A1_HUMAN, P50225
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase
    activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of
    carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer
    risk
    Catalytic activity: 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate

         Genatlas biochemistry entry for SULT1A1:
    aryl (phenol) sulfotransferase 1,phenol preferring,cytosolic,catalyzing the sulphonation of dopamine and
    p-nitrophenol

         Enzyme Numbers (IUBMB): EC 2.8.2.11 2 EC 2.8.22

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004062aryl sulfotransferase activity TAS--
    GO:0008146sulfotransferase activity TAS8661000
    GO:0047894flavonol 3-sulfotransferase activity IDA--
    GO:0050294steroid sulfotransferase activity IDA16221673
         
    SULT1A1 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-mir-631 (MIRT004760)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ST1A1_HUMAN, P50225: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0016021integral component of membrane ----

    SULT1A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SULT1A1 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Tamoxifen Pathway, Pharmacokinetics0.00
    Phase II conjugation0.56
    Tamoxifen metabolism0.00
    metapathway biotransformation0.42
    Estradiol metabolism0.00
    Cytosolic sulfonation of small molecules0.00
    Acetaminophen metabolism0.00
    2Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Arylamine metabolism0.00
    3Estrogen metabolism
    Estrogen Metabolism Pathway0.43
    Estrogen metabolism0.43
    4tryptophan utilization II
    tryptophan utilization II0.71
    melatonin degradation I0.00
    tryptophan utilization I0.71
    serotonin degradation0.00
    superpathway of melatonin degradation0.00
    5Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for SULT1A1
        Estradiol metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism
    Acetaminophen metabolism

    Selected BioSystems Pathways for SULT1A1 (see all 12)
        Vitamin A and carotenoid metabolism
    Sulfation Biotransformation Reaction
    Tamoxifen metabolism
    Arylamine metabolism
    Estrogen metabolism


    1 Reactome Pathway for SULT1A1
        Cytosolic sulfonation of small molecules

    4 PharmGKB Pathways for SULT1A1
        Acetaminophen Pathway, Pharmacokinetics
    Aromatase Inhibitor Pathway (Multiple Tissues), Pharmacodynamics
    Estrogen Metabolism Pathway
    Tamoxifen Pathway, Pharmacokinetics

    1 Kegg Pathway  (Kegg details for SULT1A1):
        Chemical carcinogenesis


    SULT1A1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SULT1A1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SULT1A1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SULT1A1 (ENSP000003219884) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BPNT1ENSP000003188524STRING: ENSP00000318852
    PAPSS1ENSP000002651744STRING: ENSP00000265174
    PAPSS2ENSP000004061574STRING: ENSP00000406157
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006584catecholamine metabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008210estrogen metabolic process IDA16221673
    GO:0009308amine metabolic process TAS8661000
    GO:0009812flavonoid metabolic process IDA--

    SULT1A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SULT1A1 (ST1A1)

    1 HMDB Compound for SULT1A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Phenolacide carbolique (see all 51)108-95-2--

    4 DrugBank Compounds for SULT1A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-3'-5'-Diphosphate-- --target--17139284 17016423
    P-Nitrophenol-- 100-02-7target--17139284 17016423
    AcetaminophenAcetaminofen (see all 5)103-90-2enzymesubstrate18232020
    TamoxifenICI-46474 (see all 3)10540-29-1enzymesubstrate22531359

    Selected Novoseek inferred chemical compound relationships for SULT1A1 gene (see all 57)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2,6-dichloro-4-nitrophenol 94.1 16 8204091 (4), 19131519 (1), 7859374 (1), 11270323 (1) (see all 8)
    phenol 87.8 153 10413297 (4), 2327787 (3), 8912648 (3), 9723178 (3) (see all 82)
    3-phosphoadenosine 5'-phosphosulfate 86.5 6 10199779 (1), 16708048 (1), 8204091 (1), 15766710 (1) (see all 5)
    p-nitrophenol 86.2 43 14609733 (3), 16413005 (3), 2390100 (2), 9566748 (2) (see all 25)
    3'-phosphoadenosine 5'-phosphate 84.9 7 16221673 (2), 15766710 (1), 12390022 (1)
    hydroxysteroid 80.7 6 1588921 (1), 8217878 (1), 8563037 (1), 12167565 (1) (see all 6)
    2-naphthol 80.7 4 8293445 (1), 11191883 (1), 16305588 (1), 10919357 (1)
    3,3'-diiodothyronine 79.8 4 10199779 (1), 11397879 (1), 15531517 (1)
    p-nitrophenyl sulfate 79.3 8 19706609 (2), 15065811 (1), 10814545 (1)
    3-nitrobenzanthrone 79 4 12419844 (2), 16601755 (1), 16331602 (1)

    1 PharmGKB related drug/compound annotation for SULT1A1 gene    About this table
    Drug/compound PharmGKB Annotation
    conjugated estrogensCA  



    SULT1A1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SULT1A1 gene (5 alternative transcripts): 
    NM_001055.3  NM_177529.2  NM_177530.2  NM_177534.2  NM_177536.3  

    Unigene Cluster for SULT1A1:

    Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
    Hs.567342  [show with all ESTs]
    Unigene Representative Sequence: BC110887
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000350842(uc002dqm.3) ENST00000564818(uc002dql.3) ENST00000567998(uc002dqj.3 uc002dqi.3 uc002dqk.3)
    ENST00000562058(uc002dqp.3 uc002dqn.3) ENST00000569554 ENST00000314752
    ENST00000563493 ENST00000566189 ENST00000567512 ENST00000395609 ENST00000395607

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      QuantiFast Probe-based Assays in human, mouse, rat SULT1A1

    Additional mRNA sequence: 

    AJ007418.1 BC000923.2 BC110887.1 BT007324.1 L10819.1 L19955.1 L19999.1 U09031.1 
    U26309.1 X84654.1 

    Selected DOTS entries (see all 29):

    DT.87016795  DT.91750583  DT.100059108  DT.100650699  DT.95365963  DT.91720316  DT.120696036  DT.100854032 
    DT.40105824  DT.91750591  DT.101983748  DT.100671058  DT.100774569  DT.91750581  DT.100675876  DT.91750579 
    DT.91750582  DT.92025528  DT.95101094  DT.100671060  DT.100680299  DT.120696163  DT.120696340  DT.120697060 

    Selected AceView cDNA sequences (see all 203):

    CR601418 BC000923 CR608214 CB148809 CB146610 NM_001055 NM_177534 T87887 
    NM_177530 BI523841 BX280592 BX283396 BI824234 CR606821 AI273979 BI832457 
    NM_177528 BG527484 BF109060 NM_177529 NM_177536 AW474726 CR618607 U28169 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SULT1A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SULT1A1 Expression
    About this image


    SULT1A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Adrenal Gland (Endocrine System)
    SULT1A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SULT1A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567342

    UniProtKB/Swiss-Prot: ST1A1_HUMAN, P50225
    Tissue specificity: Liver, lung, adrenal, brain, platelets and skin

        Pathway & Disease-focused RT2 Profiler PCR Array including SULT1A1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SULT1A1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sult1a15 sulfotransferase family 1A, phenol-preferring, member more   --   7 (69.25 cM) 126672865 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    60(a)
    59(a)
    many ↔ many
    many ↔ many
    GL343287.1(1045659-1052531)
    GL343287.1(1028874-1041016)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC643892 hypothetical protein MGC64389 72.54(n)    BC053792.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sult1st31 sulfotransferase family 1, cytosolic sulfotransferase more 55.98(n)
    50.87(a)
      368270  NM_183348.2  NP_899191.2 


    ENSEMBL Gene Tree for SULT1A1 (if available)
    TreeFam Gene Tree for SULT1A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SULT1A1 gene
    SULT1C32  SULT4A12  SULT1B12  SULT1A22  SULT1C42  SULT1C22  SULT1E12  SULT2B12  
    SULT1A42  SULT2A12  SULT6B12  SULT1A32  
    15 SIMAP similar genes for SULT1A1 using alignment to 5 protein entries:     ST1A1_HUMAN (see all proteins):
    STP1    MPV17L    SULT1A4    SULT1A3    ST1A5    SULT1A2
    SULT1E1    SULT1B1    SULT1C2    SULT2A1    SULT1C3    SULT2B1
    SULT1C4    SULT6B1    SULT4A1

    SULT1A1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SULT1A1
    PGOHUM00000240838


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SULT1A1 (see all 654)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3719023301,2
    C--28616516(+) TGTAT-/TTTTTT 5 -- ds50010--------
    rs47880691,2
    C,F,A,H--28616665(-) GCAGTG/TGGCTG 5 -- ds500118Minor allele frequency- T:0.25NS EA NA CSA WA 2216
    rs1810307011,2
    --28616694(+) TCAGGC/TGATCC 5 -- ds50010--------
    rs29256221,2
    H--28616701(+) atcctC/Actgcc 5 -- ds50014Minor allele frequency- A:0.00NS EA 416
    rs47880681,2
    C,F,A--28616723(-) TCCCAG/ACTACT 5 -- ds50016Minor allele frequency- A:0.24NA WA EA 364
    rs1855554551,2
    --28616912(+) ATTCTC/TTTTTT 5 -- ut310--------
    rs1171026581,2
    F--28617051(+) CCTACC/TGTCCC 5 -- ut311Minor allele frequency- T:0.01EA 120
    rs1450538911,2
    --28617052(+) CTACCA/GTCCCG 5 -- ut310--------
    rs10421571,2
    C,F,H--28617057(-) GGGCCC/G/TGGGAC 10 -- ut31 ese319MN EA NS NA CSA WA 1233
    rs1147939111,2
    --28617101(+) AGGTTA/TGATTC 5 -- ut310--------

    HapMap Linkage Disequilibrium report for SULT1A1 (28616903 - 28634946 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SULT1A1 (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv435671CNV Deletion17901297
    esv2667967CNV Deletion23128226
    esv2714170CNV Deletion23290073
    nsv820569CNV Duplication20802225
    nsv1775CNV Insertion18451855
    nsv509608CNV Insertion20534489
    nsv905694CNV Loss21882294
    nsv827606CNV Loss20364138
    dgv12n14CNV Loss18776910
    nsv905696CNV Loss21882294

    Human Gene Mutation Database (HGMD): SULT1A1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SULT1A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SULT1A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 171150    OMIM disorders: --

    Selected diseases for SULT1A1 (see all 34):    
    About MalaCards
    batten disease    familial breast cancer    lung cancer susceptibility    hepatitis b virus infection
    testicular germ cell tumor    germ cell tumors    colorectal cancer    esophageal cancer
    hepatitis b    oral squamous cell carcinoma    ulcerative colitis    prostate cancer
    breast cancer    acute myeloid leukemia    inflammatory bowel disease    prostatitis
    coronary artery disease    lung cancer    hepatitis    asthma

    1 disease from the University of Copenhagen DISEASES database for SULT1A1:
    Breast cancer

    SULT1A1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SULT1A1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    batten disease 53.1 2 7668357 (2)
    breast cancer 48.3 59 16150108 (4), 15894657 (3), 16637266 (3), 15743503 (3) (see all 29)
    colon carcinoma 39.9 3 10864017 (2), 11558573 (1)
    cancer 35.6 25 12402313 (3), 15949571 (2), 17619904 (2), 16402077 (1) (see all 18)
    endometrial cancer 31.9 6 18318428 (4)
    bladder cancer 21.1 4 14643027 (2), 15122594 (1)
    colorectal cancer 12 16 17013894 (5), 16425401 (3), 17603900 (1), 12419832 (1) (see all 5)
    genetic susceptibility 10.2 2 12725421 (1), 18368507 (1)
    metastasis 5.36 1 16232327 (1)
    carcinoma squamous cell 0 3 19126640 (1), 16272171 (1)

    Genetic Association Database (GAD): SULT1A1
    Human Genome Epidemiology (HuGE) Navigator: SULT1A1 (122 documents)

    Export disorders for SULT1A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SULT1A1 gene, integrated from 10 sources (see all 337):
    (articles sorted by number of sources associating them with SULT1A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16. (PubMed id 8912648)1, 2, 3, 9 Dooley T.P. and Huang Z. (Biochem. Biophys. Res. Commun. 1996)
    2. Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7. (PubMed id 8288252)1, 2, 3, 9 Dooley T.P.... Siciliano M.J. (Genomics 1993)
    3. Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2. (PubMed id 10762004)1, 2, 4, 9 Engelke C.E.... Glatt H. (Pharmacogenetics 2000)
    4. Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. (PubMed id 17947222)1, 4, 9 Gjerde J....Lien E.A. (Ann. Oncol. 2008)
    5. Association of SULT1A1 phenotype and genotype with prostate cancer risk in African-Americans and Caucasians. (PubMed id 14973106)1, 4, 9 Nowell S....Lang N.P. (amp 2004)
    6. Sulfotransferase 1A1 (SULT1A1) polymorphism and susceptibility to primary brain tumors. (PubMed id 17605044)1, 4, 9 Bardakci F....Budak M. (J. Cancer Res. Clin. Oncol. 2008)
    7. Human NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms and urothelial cancer risk in Taiwan. (PubMed id 17619904)1, 4, 9 Wang Y.H....Chiou H.Y. (J. Cancer Res. Clin. Oncol. 2008)
    8. SULT1A1 genotype and susceptibility to colorectal cancer. (PubMed id 17013894)1, 4, 9 Lilla C....Chang-Claude J. (Int. J. Cancer 2007)
    9. [Association of polymorphisms in SULT1A1 and UGT1A1 Genes with breast cancer risk and phenotypes in Russian women]. (PubMed id 16637266)1, 4, 9 Shatalova E.G....Favorova O.O. (Mol. Biol. (Mosk.) 2006)
    10. Genotypic and allelic frequencies of SULT1A1 polymorphisms in women receiving adjuvant tamoxifen therapy. (PubMed id 16317586)1, 4, 9 Grabinski J.L....Kuhn J.G. (Breast Cancer Res. Treat. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6817 HGNC: 11453 AceView: SULT1A2andSULT1A1 Ensembl:ENSG00000196502 euGenes: HUgn6817
    ECgene: SULT1A1 Kegg: 6817 H-InvDB: SULT1A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SULT1A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SULT1A1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SULT1A1 gene:
    Search GeneIP for patents involving SULT1A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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