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Aliases for SULT1A1 Gene

Aliases for SULT1A1 Gene

  • Sulfotransferase Family 1A Member 1 2 3 5
  • Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 1 2 3
  • Phenol-Sulfating Phenol Sulfotransferase 1 3 4
  • Aryl Sulfotransferase 1 3 4
  • HAST1/HAST2 3 4
  • EC 2.8.2.1 4 63
  • P-PST 1 3 4
  • Ts-PST 3 4
  • ST1A1 3 4
  • ST1A3 3 4
  • STP1 3 4
  • STP 3 4
  • Thermostable Phenol Sulfotransferase1 3
  • Thermostable Phenol Sulfotransferase 4
  • Phenol Sulfotransferase 1 4
  • EC 2.8.2 63
  • TSPST1 3
  • P-PST 3
  • PST 3

External Ids for SULT1A1 Gene

Previous HGNC Symbols for SULT1A1 Gene

  • STP
  • STP1

Previous GeneCards Identifiers for SULT1A1 Gene

  • GC16M028946
  • GC16P028674
  • GC16P028431
  • GC16P028469
  • GC16M028524
  • GC16M026642

Summaries for SULT1A1 Gene

Entrez Gene Summary for SULT1A1 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT1A1 Gene

SULT1A1 (Sulfotransferase Family 1A Member 1) is a Protein Coding gene. Diseases associated with SULT1A1 include Ceroid Lipofuscinosis, Neuronal, 3 and Inhalation Anthrax. Among its related pathways are Estrogen Metabolism Pathway and Phase II conjugation. GO annotations related to this gene include sulfotransferase activity and flavonol 3-sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT1A1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Gene Wiki entry for SULT1A1 Gene

PharmGKB "VIP" Summary for SULT1A1 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1A1 Gene

Genomics for SULT1A1 Gene

Regulatory Elements for SULT1A1 Gene

Enhancers for SULT1A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SULT1A1 on UCSC Golden Path with GeneCards custom track

Promoters for SULT1A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SULT1A1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SULT1A1 gene promoter:

Genomic Location for SULT1A1 Gene

Chromosome:
16
Start:
28,605,196 bp from pter
End:
28,623,625 bp from pter
Size:
18,430 bases
Orientation:
Minus strand

Genomic View for SULT1A1 Gene

Genes around SULT1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1A1 Gene

Proteins for SULT1A1 Gene

  • Protein details for SULT1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50225-ST1A1_HUMAN
    Recommended name:
    Sulfotransferase 1A1
    Protein Accession:
    P50225
    Secondary Accessions:
    • Q2NL71
    • Q86U58
    • Q92818
    • Q9BVU6
    • Q9UGG7

    Protein attributes for SULT1A1 Gene

    Size:
    295 amino acids
    Molecular mass:
    34165 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SULT1A1 Gene

    Alternative splice isoforms for SULT1A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT1A1 Gene

Proteomics data for SULT1A1 Gene at MOPED

Post-translational modifications for SULT1A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for SULT1A1 (Cytosolic Sulfotransferase 1A1/SULT1A1)

Domains & Families for SULT1A1 Gene

Gene Families for SULT1A1 Gene

Protein Domains for SULT1A1 Gene

Suggested Antigen Peptide Sequences for SULT1A1 Gene

Graphical View of Domain Structure for InterPro Entry

P50225

UniProtKB/Swiss-Prot:

ST1A1_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1A1: view

Function for SULT1A1 Gene

Molecular function for SULT1A1 Gene

GENATLAS Biochemistry:
aryl (phenol) sulfotransferase 1,phenol preferring,cytosolic,catalyzing the sulphonation of dopamine and p-nitrophenol
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + a phenol = adenosine 3,5-bisphosphate + an aryl sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Enzyme Numbers (IUBMB) for SULT1A1 Gene

Gene Ontology (GO) - Molecular Function for SULT1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050294 steroid sulfotransferase activity IDA 16221673
genes like me logo Genes that share ontologies with SULT1A1: view
genes like me logo Genes that share phenotypes with SULT1A1: view

Animal Model Products

CRISPR Products

miRNA for SULT1A1 Gene

miRTarBase miRNAs that target SULT1A1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SULT1A1 Gene

Localization for SULT1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1A1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT1A1 Gene COMPARTMENTS Subcellular localization image for SULT1A1 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SULT1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT1A1: view

Pathways & Interactions for SULT1A1 Gene

genes like me logo Genes that share pathways with SULT1A1: view

Gene Ontology (GO) - Biological Process for SULT1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0009812 flavonoid metabolic process IDA 20056724
GO:0044281 small molecule metabolic process TAS --
GO:0051923 sulfation IDA 19548878
genes like me logo Genes that share ontologies with SULT1A1: view

No data available for SIGNOR curated interactions for SULT1A1 Gene

Drugs & Compounds for SULT1A1 Gene

(36) Drugs for SULT1A1 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetaminophen Approved Pharma Enzyme, substrate 902
Tamoxifen Approved Pharma Antagonist, Enzyme, substrate ER antagonist, Anti-Estrogens 364
Phenol Approved, Experimental Pharma 44
Conjugated Estrogens Approved Pharma 0
nolvadex Approved October 1998 Pharma 0

(27) Additional Compounds for SULT1A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phenol sulphate
  • Aryl sulfate
  • Aryl sulphate
  • phenyl hydrogen sulfate
  • phenyl hydrogen sulphate
  • phenylsulfate
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with SULT1A1: view

Transcripts for SULT1A1 Gene

Unigene Clusters for SULT1A1 Gene

Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1A1 Gene

No ASD Table

Relevant External Links for SULT1A1 Gene

GeneLoc Exon Structure for
SULT1A1
ECgene alternative splicing isoforms for
SULT1A1

Expression for SULT1A1 Gene

mRNA expression in normal human tissues for SULT1A1 Gene

mRNA differential expression in normal tissues according to GTEx for SULT1A1 Gene

This gene is overexpressed in Liver (x6.7) and Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for SULT1A1 Gene

This gene is overexpressed in Gallbladder (34.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SULT1A1 Gene



SOURCE GeneReport for Unigene cluster for SULT1A1 Gene Hs.567342

mRNA Expression by UniProt/SwissProt for SULT1A1 Gene

P50225-ST1A1_HUMAN
Tissue specificity: Liver, lung, adrenal, brain, platelets and skin.
genes like me logo Genes that share expression patterns with SULT1A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for SULT1A1 Gene

Orthologs for SULT1A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT1A1 35
  • 98.98 (n)
  • 99.66 (a)
SULT1A1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SULT1A1 36
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SULT1A1 36
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sult1a1 36
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sult1a1 35
  • 62.7 (n)
  • 58.74 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC64389 35
zebrafish
(Danio rerio)
Actinopterygii sult1st3 35
  • 55.98 (n)
  • 50.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16733 37
  • 27 (a)
CG5428 37
  • 32 (a)
Species with no ortholog for SULT1A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT1A1 Gene

ENSEMBL:
Gene Tree for SULT1A1 (if available)
TreeFam:
Gene Tree for SULT1A1 (if available)

Paralogs for SULT1A1 Gene

Pseudogenes.org Pseudogenes for SULT1A1 Gene

genes like me logo Genes that share paralogs with SULT1A1: view

Variants for SULT1A1 Gene

Sequence variations from dbSNP and Humsavar for SULT1A1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_007425 -
VAR_009302 -
VAR_009303 -
VAR_014889 -
VAR_028721 -

Structural Variations from Database of Genomic Variants (DGV) for SULT1A1 Gene

Variant ID Type Subtype PubMed ID
dgv842e1 CNV Complex 17122850
dgv843e1 CNV Complex 17122850
nsv509608 CNV Insertion 20534489
nsv833182 CNV Gain 17160897
nsv905690 CNV Gain 21882294
dgv2664n71 CNV Gain 21882294
nsv905694 CNV Loss 21882294
nsv9416 CNV Gain+Loss 18304495
dgv12n14 CNV Loss 18776910
nsv1775 CNV Insertion 18451855
esv2667967 CNV Deletion 23128226
esv2714170 CNV Deletion 23290073
nsv827606 CNV Loss 20364138
nsv820569 CNV Duplication 20802225
nsv433301 CNV Loss 18776910
nsv905695 CNV Gain+Loss 21882294
nsv905696 CNV Loss 21882294
nsv827607 CNV Gain+Loss 20364138
nsv819128 CNV Loss 19587683
esv24682 CNV Gain+Loss 19812545
nsv435671 CNV Deletion 17901297
nsv433302 CNV Loss 18776910
nsv827608 CNV Gain+Loss 20364138
nsv905697 CNV Gain 21882294
esv33847 CNV Gain 17666407
esv993722 CNV Gain 20482838
esv998803 CNV Gain 20482838
nsv905698 CNV Gain 21882294

Variation tolerance for SULT1A1 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SULT1A1 Gene

Human Gene Mutation Database (HGMD)
SULT1A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1A1 Gene

Disorders for SULT1A1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SULT1A1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
ceroid lipofuscinosis, neuronal, 3
  • batten disease
inhalation anthrax
  • pulmonary anthrax
plague
  • yersiniosis
pneumonic plague
  • primary pneumonic plague
toxocariasis
  • infection by toxascaris
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SULT1A1

Genetic Association Database (GAD)
SULT1A1
Human Genome Epidemiology (HuGE) Navigator
SULT1A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SULT1A1
genes like me logo Genes that share disorders with SULT1A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULT1A1 Gene

Publications for SULT1A1 Gene

  1. Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16. (PMID: 8912648) Dooley T.P. … Huang Z. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23 67
  2. Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7. (PMID: 8288252) Dooley T.P. … Siciliano M.J. (Genomics 1993) 2 3 23
  3. The loss of phenol sulfotransferase 1 in hepatocellular carcinogenesis. (PMID: 19904771) Yeo M. … Cho S.W. (Proteomics 2010) 3 23
  4. Activity of sulfotransferase 1A1 is dramatically upregulated in patients with hepatocellular carcinoma secondary to chronic hepatitis B virus infection. (PMID: 19906068) Wang X.R. … Wu M.C. (Cancer Sci. 2010) 3 23
  5. Sulfotransferase 1A1 haplotypes associated with oral squamous cell carcinoma susceptibility in male Taiwanese. (PMID: 19126640) Chung Y.T. … Liu T.Y. (Carcinogenesis 2009) 3 23

Products for SULT1A1 Gene

Sources for SULT1A1 Gene

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