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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SULT1A1 Gene

protein-coding   GIFtS: 68
GCID: GC16M028616

sulfotransferase family, cytosolic, 1A, phenol-preferring,...


(Previous symbols: STP, STP1)
 Explore 43 diseases affiliated with
SULT1A1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SULT1A1    

Aliases
for SULT1A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 11 2     EC 2.8.2.13 8
STP1 2 3 5     PST2 5
STP11 2 3 5     TSPST12
P-PST1 2     Sulfotransferase 1A12
Aryl Sulfotransferase 12 3     Thermostable Phenol Sulfotransferase12
Phenol-Sulfating Phenol Sulfotransferase 12 3     Ts-PST3
HAST1/HAST22 3     Ts-PST3
ST1A12 3     Phenol Sulfotransferase 13
ST1A32 3     Thermostable Phenol Sulfotransferase3
P-PST 12 3     EC 2.8.28

External Ids:    HGNC: 114531   Entrez Gene: 68172   Ensembl: ENSG000001965027   OMIM: 1711505   UniProtKB: P502253   

Export aliases for SULT1A1 gene to outside databases

Previous GC identifers: GC16M028946 GC16P028674 GC16P028431 GC16P028469 GC16M028524 GC16M026642


Summaries
for SULT1A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SULT1A1:
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic
compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene
structure (number and length of exons) is similar among family members. This gene encodes one of two phenol
sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms
have been identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ST1A1_HUMAN, P50225
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase
activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of
carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk

Gene Wiki entry for SULT1A1

PharmGKB "VIP" summary for SULT1A1


Genomic Views
for SULT1A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SULT1A1 gene promoter:
         STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SULT1A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SULT1A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SULT1A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.1   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p12.1

SULT1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT1A1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M028616:  view genomic region     (about GC identifiers)

Start:
 28,616,903 bp from pter      End:
 28,634,946 bp from pter
Size:
 18,044 bases      Orientation:
 minus strand

Proteins
for SULT1A1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ST1A1_HUMAN, P50225 (See protein sequence)
Recommended Name: Sulfotransferase 1A1  
Size: 295 amino acids; 34165 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
6/11 PDB 3D structures from and Proteopedia for SULT1A1 (see all 11):
1LS6 (3D)        1Z28 (3D)        2D06 (3D)        3QVU (3D)        3QVV (3D)        3U3J (3D)    
Secondary accessions: Q2NL71 Q86U58 Q92818 Q9BVU6 Q9UGG7
Alternative splicing: 2 isoforms:  P50225-1   P50225-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SULT1A1: NX_P50225

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P50225

    • 4/14 DME Specific Peptides for SULT1A1 (P50225) (see all 14)
     LYLFYED  FTVAQNE  VSYYHFY  SPFMRKG 

    SULT1A1 Protein expression data from MOPED and PaxDb:    About this image 
    SULT1A1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001046.2  NP_803565.1  NP_803566.1  NP_803878.1  NP_803880.1  

    ENSEMBL proteins: 
     ENSP00000329399   ENSP00000454388   ENSP00000456215   ENSP00000457912   ENSP00000321988  
     ENSP00000457083   ENSP00000456459   ENSP00000455979   ENSP00000378972   ENSP00000378971  
    Reactome Protein details: P50225
    Human Recombinant Protein Products for SULT1A1: 
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    R&D Systems Recombinant & Natural Proteins for SULT1A1 (Cytosolic Sulfotransferase 1A1/SULT1A1)
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    OriGene Purified Proteins (see all 4): SULT1A1
    OriGene Protein Over-expression Lysate (see all 8): SULT1A1
    OriGene Custom Protein Services for SULT1A1 
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    Novus Biologicals SULT1A1 Protein
    Novus Biologicals SULT1A1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SULT1A1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0016021integral to membrane ----

    SULT1A1 for ontologies           About GeneDecksing



    SULT1A1 Antibody Products: 
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    Assay Products for SULT1A1: 
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    Uscn ELISAs and CLIAs for SULT1A1

    Protein Domains /
    Families
    for SULT1A1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SULT1A1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry P50225

    ProtoNet protein and cluster: P50225

    1 Blocks protein family: IPB000863 Sulfotransferase

    UniProtKB/Swiss-Prot: ST1A1_HUMAN, P50225
    Similarity: Belongs to the sulfotransferase 1 family


    Function
    for SULT1A1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST1A1_HUMAN, P50225
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase
    activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of
    carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk
    Catalytic activity: 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate

         Genatlas biochemistry entry for SULT1A1:
    aryl (phenol) sulfotransferase 1,phenol preferring,cytosolic,catalyzing the sulphonation of dopamine and p-nitrophenol

         Enzyme Numbers (IUBMB): EC 2.8.2.11 2 EC 2.8.22

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004062aryl sulfotransferase activity TAS--
    GO:0008146sulfotransferase activity TAS8661000
    GO:0047894flavonol 3-sulfotransferase activity IDA--
    GO:0050294steroid sulfotransferase activity IDA16221673
         
    SULT1A1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SULT1A1 

    miRNA
    Products:            		miRTarBase miRNAs that target SULT1A1:
    hsa-mir-631 (MIRT004760)

    OriGene 3'-UTR Clone (see all 5): SULT1A1
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SULT1A1
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    SwitchGear 3'UTR luciferase reporter plasmid: SULT1A1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SULT1A1 (see all 7)
    OriGene shRNA RFP: SULT1A1
    OriGene siRNA: SULT1A1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SULT1A1
    Sirion Biotech Custom design and validation of potent shRNA sequences against SULT1A1 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SULT1A1
    Sirion Biotech Customized adenovirus for overexpression of SULT1A1 
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    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SULT1A1 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): SULT1A1 (NM_177529)
    Sino Biological Human cDNA Clone for SULT1A1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SULT1A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SULT1A1 

    Cell Line
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    Search LifeMap BioReagents cell lines for SULT1A1
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT1A1


    Pathways & Interactions
    for SULT1A1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Acetaminophen Pathway, Pharmacokinetics
    		Pathway_PA165986194 -need delete1.00
    		Acetaminophen metabolism0.43
    		Acetaminophen Pathway, Pharmacokinetics1.00
    		Acetaminophen metabolism0.43
    2Tamoxifen metabolism
    		Tamoxifen metabolism1.00
    		Estradiol metabolism0.52
    		Tamoxifen Pathway, Pharmacokinetics0.68
    		Estradiol metabolism0.52
    3Cytosolic sulfonation of small molecules
    		Cytosolic sulfonation of small molecules1.00
    		Sulfur metabolism0.44
    		Sulfation Biotransformation Reaction0.67
    4Biological oxidations
    		Biological oxidations1.00
    		metapathway biotransformation0.41
    		Phase II conjugation0.52
    52-Naphthylamine and 2-Nitronaphtalene metabolism
    		2-Naphthylamine and 2-Nitronaphtalene metabolism1.00
    		2-Naphthylamine and 2-Nitronaphtalene metabolism0.95

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for SULT1A1
        Estradiol metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism
    Acetaminophen metabolism


    3 GeneGo (Thomson Reuters) Pathways for SULT1A1
        Estradiol metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism
    Acetaminophen metabolism

    5/11 BioSystems Pathways for SULT1A1 (see all 11) 
        Vitamin A and carotenoid metabolism
    Sulfation Biotransformation Reaction
    melatonin degradation I
    Estrogen metabolism
    dopamine degradation

    4        Reactome Pathways for SULT1A1
        Metabolism
    Biological oxidations
    Cytosolic sulfonation of small molecules
    Phase II conjugation

    5 PharmGKB Pathways for SULT1A1
        Acetaminophen Pathway, Pharmacokinetics
    Aromatase Inhibitor Pathway (Multiple Tissues), Pharmacodynamics
    Estrogen Metabolism Pathway
    Pathway_PA165986194 -need delete
    Tamoxifen Pathway, Pharmacokinetics

    1         Kegg Pathway  (Kegg details for SULT1A1):
        Sulfur metabolism


    SULT1A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SULT1A1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SULT1A1 (ENSP000003219884) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BPNT1ENSP000003188524STRING: ENSP00000318852
    PAPSS1ENSP000002651744STRING: ENSP00000265174
    PAPSS2ENSP000004061574STRING: ENSP00000406157
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006584catecholamine metabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008210estrogen metabolic process IDA16221673
    GO:0009308amine metabolic process TAS8661000
    GO:0009812flavonoid metabolic process IDA--

    SULT1A1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SULT1A1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SULT1A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SULT1A1

    1 HMDB Compound for SULT1A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Phenolacide carbolique (see all 51)108-95-2--

    2 DrugBank Compounds for SULT1A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-3'-5'-Diphosphate-- --target--17139284 17016423
    P-Nitrophenol-- 100-02-7target--17139284 17016423

    10/57 Novoseek chemical compound relationships for SULT1A1 gene (see all 57)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2,6-dichloro-4-nitrophenol 94.1 16 8204091 (4), 19131519 (1), 7859374 (1), 11270323 (1) (see all 8)
    phenol 87.8 153 10413297 (4), 2327787 (3), 8912648 (3), 9723178 (3) (see all 82)
    3-phosphoadenosine 5'-phosphosulfate 86.5 6 10199779 (1), 16708048 (1), 8204091 (1), 15766710 (1) (see all 5)
    p-nitrophenol 86.2 43 14609733 (3), 16413005 (3), 2390100 (2), 9566748 (2) (see all 25)
    3'-phosphoadenosine 5'-phosphate 84.9 7 16221673 (2), 15766710 (1), 12390022 (1)
    hydroxysteroid 80.7 6 1588921 (1), 8217878 (1), 8563037 (1), 12167565 (1) (see all 6)
    2-naphthol 80.7 4 8293445 (1), 11191883 (1), 16305588 (1), 10919357 (1)
    3,3'-diiodothyronine 79.8 4 10199779 (1), 11397879 (1), 15531517 (1)
    p-nitrophenyl sulfate 79.3 8 19706609 (2), 15065811 (1), 10814545 (1)
    3-nitrobenzanthrone 79 4 12419844 (2), 16601755 (1), 16331602 (1)

    1 PharmGKB related drug/compound annotation for SULT1A1 gene    About this table
    Drug/compound PharmGKB Annotation
    conjugated estrogensCA  
    Search CenterWatch for drugs/clinical trials and news about SULT1A1 / ST1A1 

    Transcripts
    for SULT1A1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SULT1A1 gene (5 alternative transcripts): 
    NM_001055.3  NM_177529.2  NM_177530.2  NM_177534.2  NM_177536.3  

    Unigene Cluster for SULT1A1:

    Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
    Hs.567342  [show with all ESTs]
    Unigene Representative Sequence: BC110887
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000350842(uc002dqm.3) ENST00000564818(uc002dql.3) ENST00000567998(uc002dqj.3 uc002dqi.3 uc002dqk.3)
    ENST00000562058(uc002dqp.3 uc002dqn.3) ENST00000569554 ENST00000314752
    ENST00000563493 ENST00000566189 ENST00000567512 ENST00000395609 ENST00000395607


    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SULT1A1
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    Additional cDNA sequence: 

    AJ007418.1 BC000923.2 BC110887.1 BT007324.1 L10819.1 L19955.1 L19999.1 U09031.1 
    U26309.1 X84654.1 

    24/29 DOTS entries (see all 29):

    DT.87016795  DT.91750583  DT.100059108  DT.100650699  DT.95365963  DT.91720316  DT.120696036  DT.100854032 
    DT.40105824  DT.91750591  DT.101983748  DT.100671058  DT.100774569  DT.91750581  DT.100675876  DT.91750579 
    DT.91750582  DT.92025528  DT.95101094  DT.100671060  DT.100680299  DT.120696163  DT.120696340  DT.120697060 

    24/203 AceView cDNA sequences (see all 203):

    CR601418 CB148809 BF109060 NM_177530 NM_001055 BX283396 BC000923 AI273979 
    NM_177536 BI824234 NM_177528 BI832457 BX280592 AW474726 T87887 BI523841 
    NM_177529 BG527484 NM_177534 CR618607 CR608214 CR606821 CB146610 CA430701 

    GeneLoc Exon Structure


    Expression
    for SULT1A1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SULT1A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    SULT1A1 Expression
    About this image

    SULT1A1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeBody Subcutaneous White AdiposeAdipose
    AdiposeVisceral White AdiposeAdipose
    BoneMaxillary ProcessBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See SULT1A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SULT1A1

    SOURCE GeneReport for Unigene cluster: Hs.567342

    UniProtKB/Swiss-Prot: ST1A1_HUMAN, P50225
    Tissue specificity: Liver, lung, adrenal, brain, platelets and skin

        SABiosciences Expression via Pathway-Focused PCR Array including SULT1A1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    Orthologs
    for SULT1A1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SULT1A1 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 60(a)
    57(a)
    		 many ↔ many
    many ↔ many
    		 GL343287.1(1045659-1052531)
    GL343287.1(1030047-1040195)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC643892 hypothetical protein MGC64389 72.54(n)    BC053792.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sult1st71 sulfotransferase family 1, cytosolic sulfotransferase more 56.76(n)
    51.4(a)    		   100196920  NM_001139481.1  NP_001132953.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG54283 sulfotransferase 32(a)
    (best of 2)    		   59F6   --


    ENSEMBL Gene Tree for SULT1A1 (if available)
    TreeFam Gene Tree for SULT1A1 (if available) 

    Paralogs
    for SULT1A1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SULT1A1 gene
    SULT1C32  SULT4A12  SULT1B12  SULT1C42  SULT1A22  SULT1C22  SULT2B12  SULT1E12  
    SULT1A42  SULT2A12  SULT6B12  SULT1A32  
    15 SIMAP similar genes for SULT1A1 using alignment to 5 protein entries:     ST1A1_HUMAN (see all proteins):
    STP1    MPV17L    SULT1A4    SULT1A3    ST1A5    SULT1A2
    SULT1E1    SULT1B1    SULT1C2    SULT2A1    SULT1C3    SULT2B1
    SULT1C4    SULT6B1    SULT4A1

    SULT1A1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SULT1A1
    PGOHUM00000240838


    Genomic Variants
    for SULT1A1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/532 NCBI SNPs in SULT1A1 are shown (see all 532)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs47880691,2
    		C,F,A,H--28616665(-) GCAGTG/TGGCTG 5 -- ds500118Minor allele frequency- T:0.25NS EA NA CSA WA 2216
    rs1810307011,2
    		--28616694(+) TCAGGC/TGATCC 5 -- ds50010--------
    rs29256221,2
    		H--28616701(+) atcctC/Actgcc 5 -- ds50014Minor allele frequency- A:0.00NS EA 416
    rs47880681,2
    		C,F,A--28616723(-) TCCCAG/ACTACT 5 -- ds50016Minor allele frequency- A:0.24NA WA EA 364
    rs1855554551,2
    		--28616912(+) ATTCTC/TTTTTT 5 -- ut310--------
    rs1171026581,2
    		--28617051(+) CCTACC/TGTCCC 5 -- ut311Minor allele frequency- T:0.01EA 120
    rs1450538911,2
    		--28617052(+) CTACCA/GTCCCG 5 -- ut310--------
    rs10421571,2
    		C,F,H--28617057(-) GGGCCC/G/TGGGAC 10 -- ut31 ese319MN EA NS NA CSA WA 1233
    rs1147939111,2
    		--28617101(+) AGGTTA/TGATTC 5 -- ut310--------
    rs68391,2
    		C,F--28617128(-) CCTGGA/GGTCAC 5 -- ut31 ese314Minor allele frequency- G:0.34MN NA CSA 1030

    HapMap Linkage Disequilibrium report for SULT1A1 (28616903 - 28634946 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 14 variations for SULT1A1
         14 CNVs: 23183 72515 32108 35379 77258 32107 3999 77257 77259 30771 58759 7099 4938 72514
    Human Gene Mutation Database (HGMD): SULT1A1

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    Disorders / Diseases
    for SULT1A1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SULT1A1 for disorders           About GeneDecksing

    OMIM gene information: 171150    OMIM disorders: --

    20/43 diseases for SULT1A1 (see all 43):    About MalaCards
    testicular germ cell tumor    batten disease    germ cell tumor    birth defects
    oral squamous cell carcinoma    squamous cell carcinoma    breast cancer susceptibility    inflammatory bowel disease
    bronchial asthma    acute myeloid leukemia    breast cancer    plague
    myeloid leukemia    ulcerative colitis    endometrial cancer    familial prostate cancer
    familial breast cancer    lung cancer susceptibility    colon carcinoma    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for SULT1A1:
    Breast cancer

    10/13 Novoseek disease relationships for SULT1A1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    batten disease 53.1 2 7668357 (2)
    breast cancer 48.3 59 16150108 (4), 15894657 (3), 16637266 (3), 15743503 (3) (see all 29)
    colon carcinoma 39.9 3 10864017 (2), 11558573 (1)
    cancer 35.6 25 12402313 (3), 15949571 (2), 17619904 (2), 16402077 (1) (see all 18)
    endometrial cancer 31.9 6 18318428 (4)
    bladder cancer 21.1 4 14643027 (2), 15122594 (1)
    colorectal cancer 12 16 17013894 (5), 16425401 (3), 17603900 (1), 12419832 (1) (see all 5)
    genetic susceptibility 10.2 2 12725421 (1), 18368507 (1)
    metastasis 5.36 1 16232327 (1)
    carcinoma squamous cell 0 3 19126640 (1), 16272171 (1)

    Genetic Association Database (GAD): SULT1A1
    Human Genome Epidemiology (HuGE) Navigator: SULT1A1 (122 documents)

    Export disorders for SULT1A1 gene to outside databases

    Publications
    for SULT1A1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SULT1A1 gene, integrated from 9 sources (see all 330):
    (articles sorted by number of sources associating them with SULT1A1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16. (PubMed id 8912648)1, 2, 3, 9 Dooley T.P. and Huang Z. (1996)
    2. Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7. (PubMed id 8288252)1, 2, 3, 9 Dooley T.P.... Siciliano M.J. (1993)
    3. Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2. (PubMed id 10762004)1, 2, 4, 9 Engelke C.E.... Glatt H. (2000)
    4. Association of SULT1A1 phenotype and genotype with prostate cancer risk in African-Americans and Caucasians. (PubMed id 14973106)1, 4, 9 Nowell S....Lang N.P. (2004)
    5. Genotypic and allelic frequencies of SULT1A1 polymorphisms in women receiving adjuvant tamoxifen therapy. (PubMed id 16317586)1, 4, 9 Grabinski J.L....Kuhn J.G. (2006)
    6. Phenotype-genotype relationships of SULT1A1 in human liver and variations in the IC50 of the SULT1A1 inhibitor quercetin. (PubMed id 15516026)1, 4, 9 Rossi A.M....Pacifici G.M. (2004)
    7. A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking. (PubMed id 14688021)1, 4, 9 Liang G....Lin D. (2004)
    8. Sulfotransferase 1A1 (SULT1A1) polymorphism and bladder cancer risk: a case-control study. (PubMed id 14643027)1, 4, 9 Zheng L....Wu X. (2003)
    9. Sulfotransferase 1A1 (SULT1A1) polymorphism, PAH-DNA adduct levels in breast tissue and breast cancer risk in a case-control study. (PubMed id 12725421)1, 4, 9 Tang D....Perera F. (2003)
    10. Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition. (PubMed id 12471039)1, 2, 9 Gamage N.U.... Martin J.L. (2003)

    External Searches for SULT1A1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SULT1A1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6817 HGNC: 11453 AceView: SULT1A2andSULT1A1 Ensembl:ENSG00000196502 euGenes: HUgn6817
    ECgene: SULT1A1 Kegg: 6817 H-InvDB: SULT1A1

    Other Databases showing SULT1A1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SULT1A1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SULT1A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SULT1A1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SULT1A1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SULT1A1 gene:
    Search GeneIP for patents involving SULT1A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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