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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SULF2 Gene

protein-coding GIFtS: 55
GCID: GC20M046285

sulfatase 2

Explore 8 diseases affiliated with
SULF2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sulfatase 2¹ ²		EC 3.1.6.-³
KIAA1247¹ ³ ⁵		HSulf-2¹
HSULF-2¹ ²		EC 3.1.6⁸
SULF-2¹		EC 3.1.6.14⁸
Extracellular Sulfatase Sulf-2²

External Ids:	HGNC: 20392¹	Entrez Gene: 55959²	Ensembl: ENSG00000196562⁷	OMIM: 610013⁵	UniProtKB: Q8IWU5³

Export aliases for SULF2 gene to outside databases

Previous GC identifers: GC20M045974 GC20M046924 GC20M046971 GC20M045719 GC20M043027

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SULF2:

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and

are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate

groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for

signaling molecules (Dai et al., 2005 (PubMed 16192265)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SULF2_HUMAN, Q8IWU5

Function: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove

sulfate from the C-6 position of glucosamine within specific subregions of intact heparin

Gene Wiki entry for SULF2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SULF2 gene promoter:
Max1 HFH-3 AML1a NF-kappaB FOXI1 Nkx6-1 NF-kappaB2 NF-kappaB1 Pax-4a c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SULF2 promoter sequence

Search SABiosciences Chromatin IP Primers for SULF2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SULF2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.2 Ensembl cytogenetic band: 20q13.13 HGNC cytogenetic band: 20q13.12-q13.13

SULF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULF2 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M046285: view genomic region (about GC identifiers)

Start:	46,285,092 bp from pter	End:	46,415,360 bp from pter
Size:	130,269 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SULF2_HUMAN, Q8IWU5 (See protein sequence)

Recommended Name: Extracellular sulfatase Sulf-2 precursor

Size: 870 amino acids; 100455 Da

Cofactor: Binds 1 calcium ion per subunit (By similarity)

Subcellular location: Endoplasmic reticulum (By similarity). Golgi apparatus, Golgi stack (By similarity). Cell surface

(By similarity). Note=Also localized on the cell surface (By similarity)

Sequence caution: Sequence=AAH20962.1; Type=Erroneous initiation; Sequence=BAA86561.2; Type=Erroneous initiation;

Sequence=CAB61349.1; Type=Erroneous initiation;

Secondary accessions: E1P5U6 Q5JYE1 Q6UX86 Q96SG2 Q9H1H0 Q9UJR3 Q9ULH3

Alternative splicing: 2 isoforms: Q8IWU5-1 Q8IWU5-2 (May be due to a competing acceptor splice site)

Explore the universe of human proteins at neXtProt for SULF2: NX_Q8IWU5

Post-translational modifications:

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes

and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IWU5

4/19 DME Specific Peptides for SULF2 (Q8IWU5) (see all 19)

TTPMCCP

NETHNFL

NNNTYWC

GKYLNEY

SULF2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001155313.1 NP_061325.1 NP_940998.2

ENSEMBL proteins:

ENSP00000353007 ENSP00000418290 ENSP00000417894 ENSP00000418442 ENSP00000410026

ENSP00000354662

Human Recombinant Protein Products:

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	Uscn Proteins for SULF2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	NAS	12368295
GO:0005783	endoplasmic reticulum	IDA	18687675
GO:0005794	Golgi apparatus	--	--
GO:0005795	Golgi stack	IEA	--
GO:0005886	plasma membrane	ISS	--

SULF2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SULF2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SULF2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR014615 Extracellular_sulfatase

IPR000917 Sulfatase

IPR017849 Alkaline_Pase-like_a/b/a

IPR024609 Extracellular_sulfatase_C

IPR024607 Sulfatase_CS

Graphical View of Domain Structure for InterPro Entry Q8IWU5

ProtoNet protein and cluster: Q8IWU5

1 Blocks protein family: IPB000917 Sulfatase

UniProtKB/Swiss-Prot: SULF2_HUMAN, Q8IWU5

Similarity: Belongs to the sulfatase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SULF2_HUMAN, Q8IWU5

Function: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove

sulfate from the C-6 position of glucosamine within specific subregions of intact heparin

Biophysicochemical properties: pH dependence: Optimum pH is 7.0-8.0;

Enzyme Numbers (IUBMB): EC 3.1.6.-¹ EC 3.1.6.14² EC 3.1.6²

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SULF2 Browse MicroRNA Expression Plasmids
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		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SULF2 (see all 17):
		hsa-miR-140-5p hsa-miR-3164 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-330-3p

		SwitchGear 3'UTR luciferase reporter plasmid: SULF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SULF2
		Search LifeMap BioReagents cell lines for SULF2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULF2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004065	arylsulfatase activity	IMP	19520866
GO:0005509	calcium ion binding	IEA	--
GO:0008449	N-acetylglucosamine-6-sulfatase activity	IMP	19520866
GO:0008484	sulfuric ester hydrolase activity	--	--

SULF2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for SULF2:

Decreased influenza A H1N1 (A/

Decreased influenza A/WSN/33 r

Animal Models:
Mouse knock-outs for SULF2: Sulf2^tm1Clrm Sulf2^tm1.1Cpe
14 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Sulf2):

cellular	craniofacial	digestive/alimentary	embryogenesis	growth/size
limbs/digits/tail	mortality/aging	muscle	nervous system	renal/urinary system
reproductive system	respiratory system	skeleton	vision/eye

SULF2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SULF2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for SULF2 (Q8IWU5³ ENSP00000353007⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EXOC5	O00471³	I2D: score=4
MYC	ENSP00000367207⁴	STRING: ENSP00000367207

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001822	kidney development	ISS	--
GO:0002063	chondrocyte development	ISS	--
GO:0003094	glomerular filtration	ISS	--
GO:0010575	positive regulation vascular endothelial growth factor production	ISS	--
GO:0014846	esophagus smooth muscle contraction	ISS	--

SULF2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SULF2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SULF2

1 HMDB Compound for SULF2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

3 Novoseek chemical compound relationships for SULF2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
heparan sulfate	82.4	8	18213582 (2), 17855356 (1), 19822709 (1), 19900405 (1) (see all 6)
glucosamine	64.7	2	19900405 (1), 16417632 (1)
heparin	57.8	13	16417632 (5), 15843596 (1), 19822709 (1), 12740361 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about SULF2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SULF2 gene (3 alternative transcripts):

NM_001161841.1 NM_018837.3 NM_198596.2

Unigene Cluster for SULF2:

Sulfatase 2

Hs.162016 [show with all ESTs]

Unigene Representative Sequence: AB033073

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000479472 ENST00000359930(uc002xto.3) ENST00000479970 ENST00000484875(uc010zyd.2 uc002xtr.3 uc002xtq.3)

ENST00000495544 ENST00000467815 ENST00000433632 ENST00000465769 ENST00000474450

ENST00000463221(uc010ghv.1) ENST00000437955 ENST00000478766 ENST00000361612

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SULF2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SULF2
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SULF2 (see all 17):
		hsa-miR-140-5p hsa-miR-3164 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-330-3p

		SwitchGear 3'UTR luciferase reporter plasmid: SULF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SULF2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SULF2

Additional cDNA sequence:

AB033073.2 AK074483.1 AK075035.1 AK308829.1 AL133001.1 AY101176.1 AY358461.1 BC020962.1

BC073790.1 BC090952.1 BC110538.1 BC110539.1 CR749319.1

17 DOTS entries:

DT.97857313 DT.114458 DT.86849198 DT.40281941 DT.70102985 DT.91750493 DT.100794317 DT.100794319

DT.120798865 DT.100794316 DT.91653753 DT.91750494 DT.95337731 DT.95374852 DT.95374856 DT.95374857

DT.91951875

24/227 AceView cDNA sequences (see all 227):

AA323130 BE222964 AL537332 AI356198 AA424942 AA506775 BM699986 CD673642

BM991910 BQ446116 AA716420 BQ884082 AA865313 AI972020 BQ181056 AA227090

BM843000 CB270607 BQ650076 AA494379 BM670443 BQ669211 BM703792 BC020962

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SULF2 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17	^
SP1:
SP2:
SP3:
SP4:
SP5:															-		-

ExUns:	18	^	19	^	20a	·	20b	^	21	^	22a	·	22b
SP1:
SP2:					-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SULF2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SULF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAACTTTTA

About this image

SULF2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Periportal Hepatocytes

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/11 LifeMap Cells (see all 11)

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

Midbrain dopaminergic-like neurons (Generation of midbra...)

See SULF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SULF2

SOURCE GeneReport for Unigene cluster: Hs.162016

UniProtKB/Swiss-Prot: SULF2_HUMAN, Q8IWU5

Tissue specificity: Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney

and placenta

SABiosciences Custom PCR Arrays for SULF2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SULF2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SULF2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULF2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SULF2 gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SULF2¹	sulfatase 2	76.79(n) 87(a)		419209 XM_417386.3 XP_417386.2
lizard (Anolis carolinensis)	Reptilia	SULF2⁶	--	86(a)	1 ↔ 1	4(145320417-145439463)
African clawed frog (Xenopus laevis)	Amphibia	Xl.15452²	Xenopus laevis transcribed sequence with weak similarity to protein pirKJHUGU (H.sapiens) KJHUGU N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) precursor - human less	79.76(n)		CB200492.2
zebrafish (Danio rerio)	Actinopterygii	zgc55612²	similar to sulfatase 2	75.89(n)		393910 BC045403.1
fruit fly (Drosophila melanogaster)	Insecta	Sulf1⁶	Sulfated	32(a)	1 → many	3R(12136264-12164260)
worm (Caenorhabditis elegans)	Secernentea	sul-1⁶	Putative extracellular sulfatase Sulf-1 homolog	43(a)	1 → many	X(3267283-3270851)
E. coli (Escherichia coli)	Gamma proteobacteria	yidJ⁶	predicted sulfatase/phosphatase	16(a)	possible ortholog	Chromosome(3854934-3856427)

ENSEMBL Gene Tree for SULF2 (if available)
TreeFam Gene Tree for SULF2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SULF2 gene

SULF1² GNS² ARSK²

4 SIMAP similar genes for SULF2 using alignment to 6 protein entries: SULF2_HUMAN (see all proteins):

SULF1 DKFZp686F13142 GNS DKFZp686E12166

SULF2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11471676^1,2	C,	--	46286122(+)	`AATAC-/TTTTTAA`	3	--	int¹		0	--	--	--	--
rs74178753^1,2	C,	--	46286153(+)	`CTCCCAAGA/- AAGAA`	3	--	ut3¹		1		NA	2
rs34633114^1,2	C,F	--	46286159(+)	`AGAAA-/GAAA TGGCC`	3	--	ut3¹		6		NA NS	184
rs147116229^1,2		--	46286219(+)	`GGGTTC/TTGAAC`	3	--	ut3¹		0	--	--	--	--
rs445219^1,2	C,F,A,H,	--	46286239(-)	`TTTAAG/CTATTG`	3	--	ut3¹ ese³		27		EA NA MN NS	2582
rs185138355^1,2		--	46286245(+)	`TTAAAC/TTACAA`	3	--	ut3¹		0	--	--	--	--
rs72646223^1,2	C,	--	46286307(+)	`CATTTC/GTTTTC`	3	--	ut3¹		6		NS EA	306
rs189076669^1,2		--	46286351(+)	`ATAACA/GAAGAA`	3	--	ut3¹		0	--	--	--	--
rs74407651^1,2	C,F,	--	46286406(+)	`ACTGCG/AAGGGA`	3	--	ut3¹		1		WA	118
rs72646225^1,2	C,	--	46286429(+)	`CTGGCC/GACAGA`	3	--	ut3¹		5		NS	186

HapMap Linkage Disequilibrium report for SULF2 (46285092 - 46415360 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SULF2
1 CNV: 4103
1 Indel: 102980

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SULF2 for disorders           About GeneDecksing

OMIM gene information: 610013    OMIM disorders: --

8 diseases for SULF2:    About MalaCards

attention deficit hyperactivity disorder nephrotic syndrome breast adenocarcinoma hepatocellular carcinoma

adenocarcinoma breast cancer myeloma carcinoma

1 Novoseek disease relationship for SULF2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	5	16192265 (2), 18318435 (2), 19086847 (1)

Export disorders for SULF2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SULF2 gene, integrated from 9 sources (see all 45):
(articles sorted by number of sources associating them with SULF2)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. (PubMed id 12368295)^{1, 2, 3} Morimoto-Tomita M.... Rosen S.D. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2} Nagase T.... Ohara O. (1999)
HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. (PubMed id 16417632)^{1, 9} Uchimura K....Rosen S.D. (2006)
HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. (PubMed id 16192265)^{1, 9} Dai Y....Sanderson R.D. (2005)
SULF2 methylation is prognostic for lung cancer surviv al and increases sensitivity to topoisomerase-I inhibitors via induction of ISG1 5. (PubMed id 22158045)¹ Tessema M....Belinsky S.A. (2012)
Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)¹ Toyoshima M....Grandori C. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55959	HGNC: 20392	AceView: SULF2	Ensembl:ENSG00000196562	euGenes: HUgn55959
ECgene: SULF2	H-InvDB: SULF2

(According to HUGE)
About This Section

HUGE: KIAA1247

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SULF2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SULF2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SULF2 gene:
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GeneCards and IP:
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