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Aliases for SULF2 Gene

Aliases for SULF2 Gene

  • Sulfatase 2 2 3 5
  • HSULF-2 3 4
  • EC 63
  • EC 3.1.6.- 4
  • KIAA1247 4
  • EC 3.1.6 63

External Ids for SULF2 Gene

Previous GeneCards Identifiers for SULF2 Gene

  • GC20M045974
  • GC20M046924
  • GC20M046971
  • GC20M045719
  • GC20M046285
  • GC20M043027

Summaries for SULF2 Gene

Entrez Gene Summary for SULF2 Gene

  • Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SULF2 Gene

SULF2 (Sulfatase 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and arylsulfatase activity. An important paralog of this gene is SULF1.

UniProtKB/Swiss-Prot for SULF2 Gene

  • Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.

Gene Wiki entry for SULF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULF2 Gene

Genomics for SULF2 Gene

Regulatory Elements for SULF2 Gene

Enhancers for SULF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SULF2 on UCSC Golden Path with GeneCards custom track

Promoters for SULF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SULF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SULF2 Gene

47,656,348 bp from pter
47,786,629 bp from pter
130,282 bases
Minus strand

Genomic View for SULF2 Gene

Genes around SULF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULF2 Gene

Proteins for SULF2 Gene

  • Protein details for SULF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Extracellular sulfatase Sulf-2
    Protein Accession:
    Secondary Accessions:
    • E1P5U6
    • Q5JYE1
    • Q6UX86
    • Q96SG2
    • Q9H1H0
    • Q9UJR3
    • Q9ULH3

    Protein attributes for SULF2 Gene

    870 amino acids
    Molecular mass:
    100455 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    • Sequence=AAH20962.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA86561.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB61349.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SULF2 Gene


neXtProt entry for SULF2 Gene

Proteomics data for SULF2 Gene at MOPED

Post-translational modifications for SULF2 Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Ubiquitination at Lys 694, Lys 834, and Lys 859
  • Glycosylation at Asn 65, Asn 112, Asn 132, Asn 149, Asn 171, Asn 198, Asn 241, Asn 561, Asn 608, Asn 717, Asn 754, and Asn 764
  • Modification sites at PhosphoSitePlus

Other Protein References for SULF2 Gene

Antibody Products

  • R&D Systems Antibodies for SULF2 (Sulfatase-2/SULF2)

Domains & Families for SULF2 Gene

Gene Families for SULF2 Gene

Suggested Antigen Peptide Sequences for SULF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfatase family.
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with SULF2: view

Function for SULF2 Gene

Molecular function for SULF2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.0-8.0.;
UniProtKB/Swiss-Prot Function:
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.

Enzyme Numbers (IUBMB) for SULF2 Gene

genes like me logo Genes that share phenotypes with SULF2: view

Animal Models for SULF2 Gene

MGI Knock Outs for SULF2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SULF2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SULF2 Gene

Localization for SULF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULF2 Gene

Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface. Note=Also localized on the cell surface. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SULF2 Gene COMPARTMENTS Subcellular localization image for SULF2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
plasma membrane 5
golgi apparatus 4
lysosome 2
vacuole 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SULF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 18687675
GO:0009986 cell surface IEA,IDA 12368295
genes like me logo Genes that share ontologies with SULF2: view

Pathways & Interactions for SULF2 Gene

SuperPathways for SULF2 Gene

No Data Available

Interacting Proteins for SULF2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000353007 Q8IWU5-SULF2_HUMAN for SULF2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SULF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development ISS --
GO:0003094 glomerular filtration ISS --
GO:0008152 metabolic process IEA --
GO:0030177 positive regulation of Wnt signaling pathway IDA 19520866
GO:0030201 heparan sulfate proteoglycan metabolic process NAS 12368295
genes like me logo Genes that share ontologies with SULF2: view

No data available for Pathways by source and SIGNOR curated interactions for SULF2 Gene

Drugs & Compounds for SULF2 Gene

(3) Drugs for SULF2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for SULF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SULF2: view

Transcripts for SULF2 Gene

Unigene Clusters for SULF2 Gene

Sulfatase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULF2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP5: - -
SP6: -
SP7: - - -
SP10: -

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b
SP2: -

Relevant External Links for SULF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SULF2 Gene

mRNA expression in normal human tissues for SULF2 Gene

Protein differential expression in normal tissues from HIPED for SULF2 Gene

This gene is overexpressed in Urine (60.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SULF2 Gene

SOURCE GeneReport for Unigene cluster for SULF2 Gene Hs.162016

mRNA Expression by UniProt/SwissProt for SULF2 Gene

Tissue specificity: Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta.
genes like me logo Genes that share expression patterns with SULF2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SULF2 Gene

Orthologs for SULF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SULF2 35
  • 91.45 (n)
  • 95.01 (a)
SULF2 36
  • 95 (a)
(Canis familiaris)
Mammalia SULF2 35
  • 91.56 (n)
  • 95.86 (a)
SULF2 36
  • 96 (a)
(Mus musculus)
Mammalia Sulf2 35
  • 87.99 (n)
  • 94.48 (a)
Sulf2 16
Sulf2 36
  • 94 (a)
(Pan troglodytes)
Mammalia SULF2 35
  • 97.31 (n)
  • 97.25 (a)
(Rattus norvegicus)
Mammalia Sulf2 35
  • 88.26 (n)
  • 94.25 (a)
(Monodelphis domestica)
Mammalia SULF2 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia SULF2 36
  • 74 (a)
(Gallus gallus)
Aves SULF2 35
  • 76.75 (n)
  • 86.88 (a)
SULF2 36
  • 86 (a)
(Anolis carolinensis)
Reptilia SULF2 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5319 35
sulf2 35
  • 75.76 (n)
  • 83.04 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15452 35
(Danio rerio)
Actinopterygii sulf2b 35
  • 73.32 (n)
  • 75.73 (a)
zgc55612 35
sulf2a 36
  • 68 (a)
sulf2b 36
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sulf1 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea sul-1 36
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for SULF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SULF2 Gene

Gene Tree for SULF2 (if available)
Gene Tree for SULF2 (if available)

Paralogs for SULF2 Gene

Paralogs for SULF2 Gene

(4) SIMAP similar genes for SULF2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SULF2: view

Variants for SULF2 Gene

Sequence variations from dbSNP and Humsavar for SULF2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_036494 A breast cancer sample
VAR_036495 A breast cancer sample
rs10048853 - 47,664,166(+) TGAGG(C/T)GGCCT reference, missense
rs56218501 - 47,736,892(+) GTGCG(C/G/T)CCCGC reference, missense
rs425433 -- 47,667,536(-) GGGCC(A/C)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SULF2 Gene

Variant ID Type Subtype PubMed ID
nsv833995 CNV Loss 17160897
dgv1333e1 CNV Complex 17122850
nsv513547 CNV Insertion 21212237
esv2650626 CNV Insertion 19546169
nsv3396 CNV Insertion 18451855
esv2678560 CNV Deletion 23128226
nsv524279 CNV Loss 19592680
nsv3397 CNV Loss 18451855
nsv469534 CNV Loss 16826518

Variation tolerance for SULF2 Gene

Residual Variation Intolerance Score: 11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.66; 72.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SULF2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULF2 Gene

Disorders for SULF2 Gene

Relevant External Links for SULF2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SULF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SULF2 Gene

Publications for SULF2 Gene

  1. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. (PMID: 12368295) Morimoto-Tomita M. … Rosen S.D. (J. Biol. Chem. 2002) 2 3 4 67
  2. HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. (PMID: 16417632) Uchimura K. … Rosen S.D. (BMC Biochem. 2006) 3 23
  3. HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. (PMID: 16192265) Dai Y. … Sanderson R.D. (J. Biol. Chem. 2005) 3 23
  4. Measuring sulfatase expression and invasion in glioblastoma. (PMID: 25325976) Wade A. … Phillips J.J. (Methods Mol. Biol. 2015) 3
  5. SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis. (PMID: 25444749) Singer M.S. … Rosen S.D. (Clin. Chim. Acta 2015) 3

Products for SULF2 Gene

Sources for SULF2 Gene