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Aliases for SULF2 Gene

Aliases for SULF2 Gene

  • Sulfatase 2 2 3 5
  • HSULF-2 3 4
  • Extracellular Sulfatase Sulf-2 3
  • EC 61
  • EC 3.1.6.- 4
  • KIAA1247 4
  • EC 3.1.6 61

External Ids for SULF2 Gene

Previous GeneCards Identifiers for SULF2 Gene

  • GC20M045974
  • GC20M046924
  • GC20M046971
  • GC20M045719
  • GC20M046285
  • GC20M043027

Summaries for SULF2 Gene

Entrez Gene Summary for SULF2 Gene

  • Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SULF2 Gene

SULF2 (Sulfatase 2) is a Protein Coding gene. Diseases associated with SULF2 include Juvenile Astrocytoma. GO annotations related to this gene include calcium ion binding and arylsulfatase activity. An important paralog of this gene is SULF1.

UniProtKB/Swiss-Prot for SULF2 Gene

  • Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.

Gene Wiki entry for SULF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULF2 Gene

Genomics for SULF2 Gene

Regulatory Elements for SULF2 Gene

Enhancers for SULF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G047857 1.5 Ensembl ENCODE dbSUPER 15.8 -71.5 -71507 2.2 HDGF PKNOX1 FOXA2 SIN3A YBX1 ELK1 FOS ZHX2 REST ZNF592 SULF2 SRMP1 LOC105372636
GH20G047748 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14.1 +37.4 37375 1.5 GATAD2A CTCF ZNF3 FOXA2 MAX POLR2A SCRT2 KDM1A ETV6 BCLAF1 SULF2 GC20M047707
GH20G047808 1.4 FANTOM5 ENCODE dbSUPER 14.6 -23.0 -23043 2.0 HDGF CTCF KLF1 TFAP4 NFIB TAF1 SUZ12 CEBPG ZBTB7B RAD21 SULF2 RNU7-173P
GH20G048002 1.6 FANTOM5 Ensembl ENCODE 11.6 -216.4 -216414 1.2 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZBTB7B ETS1 CBX5 SULF2 LINC01522 LOC105372639
GH20G047747 1.3 FANTOM5 ENCODE dbSUPER 14.2 +39.1 39079 0.3 HDGF ZNF335 FOSL1 ZFHX2 EGR1 SCRT2 ETV6 PRDM10 FOS EGR2 SULF2 GC20M047707
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SULF2 on UCSC Golden Path with GeneCards custom track

Promoters for SULF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SULF2 Gene

47,656,348 bp from pter
47,786,629 bp from pter
130,282 bases
Minus strand

Genomic View for SULF2 Gene

Genes around SULF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULF2 Gene

Proteins for SULF2 Gene

  • Protein details for SULF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Extracellular sulfatase Sulf-2
    Protein Accession:
    Secondary Accessions:
    • E1P5U6
    • Q5JYE1
    • Q6UX86
    • Q96SG2
    • Q9H1H0
    • Q9UJR3
    • Q9ULH3

    Protein attributes for SULF2 Gene

    870 amino acids
    Molecular mass:
    100455 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    • Sequence=AAH20962.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA86561.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB61349.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SULF2 Gene


neXtProt entry for SULF2 Gene

Selected DME Specific Peptides for SULF2 Gene


Post-translational modifications for SULF2 Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Ubiquitination at posLast=694694, Lys834, and isoforms=2859
  • Glycosylation at Asn65, Asn112, isoforms=2132, Asn149, isoforms=2171, Asn198, isoforms=2241, Asn561, Asn608, isoforms=2717, Asn754, and Asn764
  • Modification sites at PhosphoSitePlus

Domains & Families for SULF2 Gene

Gene Families for SULF2 Gene

Suggested Antigen Peptide Sequences for SULF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfatase family.
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with SULF2: view

Function for SULF2 Gene

Molecular function for SULF2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.0-8.0.;
UniProtKB/Swiss-Prot Function:
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.

Enzyme Numbers (IUBMB) for SULF2 Gene

Gene Ontology (GO) - Molecular Function for SULF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004065 arylsulfatase activity IMP 19520866
GO:0005509 calcium ion binding IEA --
GO:0008449 N-acetylglucosamine-6-sulfatase activity IMP 19520866
GO:0008484 sulfuric ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with SULF2: view
genes like me logo Genes that share phenotypes with SULF2: view

Animal Models for SULF2 Gene

MGI Knock Outs for SULF2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SULF2

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SULF2 Gene

Localization for SULF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULF2 Gene

Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface. Note=Also localized on the cell surface. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULF2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
golgi apparatus 4
lysosome 2
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SULF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space NAS 12368295
GO:0005783 endoplasmic reticulum IDA 18687675
GO:0005794 Golgi apparatus IEA --
GO:0005795 Golgi stack IEA --
GO:0005886 plasma membrane ISS --
genes like me logo Genes that share ontologies with SULF2: view

Pathways & Interactions for SULF2 Gene

SuperPathways for SULF2 Gene

No Data Available

Interacting Proteins for SULF2 Gene

Gene Ontology (GO) - Biological Process for SULF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development ISS --
GO:0002063 chondrocyte development ISS --
GO:0003094 glomerular filtration ISS --
GO:0008152 metabolic process IEA --
GO:0009611 response to wounding IEA --
genes like me logo Genes that share ontologies with SULF2: view

No data available for Pathways by source and SIGNOR curated interactions for SULF2 Gene

Drugs & Compounds for SULF2 Gene

(3) Drugs for SULF2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for SULF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SULF2: view

Transcripts for SULF2 Gene

Unigene Clusters for SULF2 Gene

Sulfatase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SULF2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP5: - -
SP6: -
SP7: - - -
SP10: -

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b
SP2: -

Relevant External Links for SULF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SULF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SULF2 Gene

Protein differential expression in normal tissues from HIPED for SULF2 Gene

This gene is overexpressed in Urine (60.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SULF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SULF2 Gene:


SOURCE GeneReport for Unigene cluster for SULF2 Gene:


mRNA Expression by UniProt/SwissProt for SULF2 Gene:

Tissue specificity: Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta.

Evidence on tissue expression from TISSUES for SULF2 Gene

  • Nervous system(4.6)
  • Intestine(4.4)
  • Liver(4.4)
  • Lung(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with SULF2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SULF2 Gene

Orthologs for SULF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SULF2 34
  • 97.31 (n)
(Canis familiaris)
Mammalia SULF2 34 35
  • 91.56 (n)
(Bos Taurus)
Mammalia SULF2 34 35
  • 91.45 (n)
(Monodelphis domestica)
Mammalia SULF2 35
  • 89 (a)
(Rattus norvegicus)
Mammalia Sulf2 34
  • 88.26 (n)
(Mus musculus)
Mammalia Sulf2 34 16 35
  • 87.99 (n)
(Ornithorhynchus anatinus)
Mammalia SULF2 35
  • 74 (a)
(Gallus gallus)
Aves SULF2 34 35
  • 76.75 (n)
(Anolis carolinensis)
Reptilia SULF2 35
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sulf2 34
  • 75.76 (n)
Str.5319 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15452 34
(Danio rerio)
Actinopterygii sulf2b 34 35
  • 73.32 (n)
sulf2a 35
  • 68 (a)
zgc55612 34
fruit fly
(Drosophila melanogaster)
Insecta Sulf1 35
  • 34 (a)
(Caenorhabditis elegans)
Secernentea sul-1 35
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
Species where no ortholog for SULF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SULF2 Gene

Gene Tree for SULF2 (if available)
Gene Tree for SULF2 (if available)

Paralogs for SULF2 Gene

Paralogs for SULF2 Gene

(4) SIMAP similar genes for SULF2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SULF2: view

Variants for SULF2 Gene

Sequence variations from dbSNP and Humsavar for SULF2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_036494 A breast cancer sample
VAR_036495 A breast cancer sample
rs1000016076 -- 47,732,749(+) GAGGC(A/C)GGAGA intron-variant
rs1000020643 -- 47,710,840(+) GGCTC(C/T)ACGCG intron-variant
rs1000031965 -- 47,710,573(+) TTCTC(A/C)GCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SULF2 Gene

Variant ID Type Subtype PubMed ID
dgv4322n100 CNV loss 25217958
esv2650626 CNV insertion 19546169
esv2678560 CNV deletion 23128226
esv2758799 CNV gain 17122850
esv3645974 CNV loss 21293372
esv3645976 CNV gain 21293372
nsv1066907 CNV gain 25217958
nsv1073065 CNV deletion 25765185
nsv1076839 CNV insertion 25765185
nsv1133507 CNV deletion 24896259
nsv1143986 CNV deletion 24896259
nsv3396 CNV insertion 18451855
nsv3397 CNV deletion 18451855
nsv469534 CNV loss 16826518
nsv513547 CNV insertion 21212237
nsv524279 CNV loss 19592680
nsv586156 CNV gain 21841781
nsv833995 CNV loss 17160897

Variation tolerance for SULF2 Gene

Residual Variation Intolerance Score: 11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.66; 72.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SULF2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULF2 Gene

Disorders for SULF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SULF2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
juvenile astrocytoma
  • pediatric astrocytoma
- elite association - COSMIC cancer census association via MalaCards
Search SULF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SULF2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SULF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULF2 Gene

Publications for SULF2 Gene

  1. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. (PMID: 12368295) Morimoto-Tomita M. … Rosen S.D. (J. Biol. Chem. 2002) 2 3 4 64
  2. Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. (PMID: 18937294) Lasky-Su J. … Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 46 64
  3. HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. (PMID: 16417632) Uchimura K. … Rosen S.D. (BMC Biochem. 2006) 3 22 64
  4. HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. (PMID: 16192265) Dai Y. … Sanderson R.D. (J. Biol. Chem. 2005) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SULF2 Gene

  • Addgene plasmids for SULF2

Sources for SULF2 Gene

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