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Aliases for SULF2 Gene

Aliases for SULF2 Gene

  • Sulfatase 2 2 3
  • KIAA1247 4 6
  • HSULF-2 3 4
  • Extracellular Sulfatase Sulf-2 3
  • EC 63
  • EC 3.1.6.- 4
  • EC 3.1.6 63

External Ids for SULF2 Gene

Previous GeneCards Identifiers for SULF2 Gene

  • GC20M045974
  • GC20M046924
  • GC20M046971
  • GC20M045719
  • GC20M046285
  • GC20M043027

Summaries for SULF2 Gene

Entrez Gene Summary for SULF2 Gene

  • Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SULF2 Gene

SULF2 (Sulfatase 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and N-acetylglucosamine-6-sulfatase activity. An important paralog of this gene is SULF1.

UniProtKB/Swiss-Prot for SULF2 Gene

  • Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin

Gene Wiki entry for SULF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULF2 Gene

Genomics for SULF2 Gene

Regulatory Elements for SULF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SULF2 Gene

47,656,348 bp from pter
47,786,629 bp from pter
130,282 bases
Minus strand

Genomic View for SULF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SULF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULF2 Gene

Proteins for SULF2 Gene

  • Protein details for SULF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Extracellular sulfatase Sulf-2
    Protein Accession:
    Secondary Accessions:
    • E1P5U6
    • Q5JYE1
    • Q6UX86
    • Q96SG2
    • Q9H1H0
    • Q9UJR3
    • Q9ULH3

    Protein attributes for SULF2 Gene

    870 amino acids
    Molecular mass:
    100455 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    No Data Available
    • Sequence=AAH20962.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA86561.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB61349.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SULF2 Gene


neXtProt entry for SULF2 Gene

Proteomics data for SULF2 Gene at MOPED

Post-translational modifications for SULF2 Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Ubiquitination at Lys694, Lys834, and Lys859
  • Glycosylation at Asn65, Asn112, Asn132, Asn149, Asn171, Asn198, Asn241, Asn561, Asn608, Asn717, Asn754, and Asn764
  • Modification sites at PhosphoSitePlus

Other Protein References for SULF2 Gene

Antibody Products

  • R&D Systems Antibodies for SULF2 (Sulfatase-2/SULF2)

Domains for SULF2 Gene

Gene Families for SULF2 Gene

Suggested Antigen Peptide Sequences for SULF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfatase family.
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with SULF2: view

Function for SULF2 Gene

Molecular function for SULF2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.0-8.0.;
UniProtKB/Swiss-Prot Function:
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin

Enzyme Numbers (IUBMB) for SULF2 Gene

Gene Ontology (GO) - Molecular Function for SULF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004065 arylsulfatase activity IMP 19520866
GO:0005509 calcium ion binding IEA --
GO:0008449 N-acetylglucosamine-6-sulfatase activity IMP 19520866
GO:0008484 sulfuric ester hydrolase activity --
genes like me logo Genes that share ontologies with SULF2: view
genes like me logo Genes that share phenotypes with SULF2: view

Animal Models for SULF2 Gene

MGI Knock Outs for SULF2:

Animal Model Products

miRNA for SULF2 Gene

miRTarBase miRNAs that target SULF2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SULF2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for SULF2 Gene

Localization for SULF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULF2 Gene

Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface. Note=Also localized on the cell surface. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SULF2 Gene COMPARTMENTS Subcellular localization image for SULF2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
plasma membrane 4
golgi apparatus 2
lysosome 2
cytoskeleton 1
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SULF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space NAS 12368295
GO:0005783 endoplasmic reticulum IDA 18687675
GO:0005794 Golgi apparatus --
GO:0005795 Golgi stack IEA --
GO:0005886 plasma membrane ISS --
genes like me logo Genes that share ontologies with SULF2: view

Pathways for SULF2 Gene

SuperPathways for SULF2 Gene

No Data Available

Interacting Proteins for SULF2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000353007 Q8IWU5-SULF2_HUMAN for SULF2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SULF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development ISS --
GO:0002063 chondrocyte development ISS --
GO:0003094 glomerular filtration ISS --
GO:0008152 metabolic process --
GO:0010575 positive regulation of vascular endothelial growth factor production ISS --
genes like me logo Genes that share ontologies with SULF2: view

No data available for Pathways by source for SULF2 Gene

Drugs for SULF2 Gene

(1) HMDB Compounds for SULF2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(3) Novoseek inferred chemical compound relationships for SULF2 Gene

Compound -log(P) Hits PubMed IDs
heparan sulfate 82.4 7
glucosamine 64.7 2
heparin 57.8 9
genes like me logo Genes that share compounds with SULF2: view

Transcripts for SULF2 Gene

Unigene Clusters for SULF2 Gene

Sulfatase 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SULF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SULF2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP5: - -
SP6: -
SP7: - - -
SP10: -

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b
SP2: -

Relevant External Links for SULF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SULF2 Gene

mRNA expression in normal human tissues for SULF2 Gene

Protein differential expression in normal tissues for SULF2 Gene

This gene is overexpressed in Urine (60.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SULF2 Gene

SOURCE GeneReport for Unigene cluster for SULF2 Gene Hs.162016

mRNA Expression by UniProt/SwissProt for SULF2 Gene

Tissue specificity: Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta
genes like me logo Genes that share expressions with SULF2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for SULF2 Gene

Orthologs for SULF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SULF2 35
  • 91.45 (n)
  • 95.01 (a)
SULF2 36
  • 95 (a)
(Canis familiaris)
Mammalia SULF2 35
  • 91.56 (n)
  • 95.86 (a)
SULF2 36
  • 96 (a)
(Mus musculus)
Mammalia Sulf2 35
  • 87.99 (n)
  • 94.48 (a)
Sulf2 16
Sulf2 36
  • 94 (a)
(Pan troglodytes)
Mammalia SULF2 35
  • 97.31 (n)
  • 97.25 (a)
(Rattus norvegicus)
Mammalia Sulf2 35
  • 88.26 (n)
  • 94.25 (a)
(Monodelphis domestica)
Mammalia SULF2 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia SULF2 36
  • 74 (a)
(Gallus gallus)
Aves SULF2 35
  • 76.75 (n)
  • 86.88 (a)
SULF2 36
  • 86 (a)
(Anolis carolinensis)
Reptilia SULF2 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5319 35
sulf2 35
  • 75.76 (n)
  • 83.04 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15452 35
(Danio rerio)
Actinopterygii sulf2b 35
  • 73.32 (n)
  • 75.73 (a)
zgc55612 35
sulf2a 36
  • 68 (a)
sulf2b 36
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sulf1 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea sul-1 36
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for SULF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SULF2 Gene

Gene Tree for SULF2 (if available)
Gene Tree for SULF2 (if available)

Paralogs for SULF2 Gene

Paralogs for SULF2 Gene

(4) SIMAP similar genes for SULF2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SULF2: view

Variants for SULF2 Gene

Sequence variations from dbSNP and Humsavar for SULF2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs403321 -- 47,666,860(+) CAGGC(A/G)GAGTG intron-variant
rs425433 -- 47,667,536(-) GGGCC(A/C)GTGAG intron-variant
rs444271 -- 47,658,268(-) CTGTG(C/G)TATTG utr-variant-3-prime
rs445219 -- 47,657,495(-) TTTAA(C/G)TATTG utr-variant-3-prime
rs450110 -- 47,662,738(-) AATAT(C/T)ACCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SULF2 Gene

Variant ID Type Subtype PubMed ID
nsv833995 CNV Loss 17160897
dgv1333e1 CNV Complex 17122850
nsv513547 CNV Insertion 21212237
esv2650626 CNV Insertion 19546169
nsv3396 CNV Insertion 18451855
esv2678560 CNV Deletion 23128226
nsv524279 CNV Loss 19592680
nsv3397 CNV Loss 18451855
nsv469534 CNV Loss 16826518

Relevant External Links for SULF2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULF2 Gene

Disorders for SULF2 Gene

(1) Novoseek inferred disease relationships for SULF2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 5

Relevant External Links for SULF2

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with SULF2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for SULF2 Gene

Publications for SULF2 Gene

  1. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. (PMID: 12368295) Morimoto-Tomita M. … Rosen S.D. (J. Biol. Chem. 2002) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. (PMID: 16192265) Dai Y. … Sanderson R.D. (J. Biol. Chem. 2005) 3 23
  5. HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. (PMID: 16417632) Uchimura K. … Rosen S.D. (BMC Biochem. 2006) 3 23

Products for SULF2 Gene

  • Addgene plasmids for SULF2

Sources for SULF2 Gene

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