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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SULF2 Gene

protein-coding   GIFtS: 58
GCID: GC20M046285

Sulfatase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sulfatase 21 2     EC 3.1.6.-3
KIAA12473 5     hSulf-23
HSULF-22     EC 3.1.68
Extracellular Sulfatase Sulf-22     EC 3.1.6.148

External Ids:    HGNC: 203921   Entrez Gene: 559592   Ensembl: ENSG000001965627   OMIM: 6100135   UniProtKB: Q8IWU53   

Export aliases for SULF2 gene to outside databases

Previous GC identifers: GC20M045974 GC20M046924 GC20M046971 GC20M045719 GC20M043027


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SULF2 Gene:
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines
and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove
6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering
binding sites for signaling molecules (Dai et al., 2005 (PubMed 16192265)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SULF2 Gene: 
SULF2 (sulfatase 2) is a protein-coding gene. Diseases associated with SULF2 include breast adenocarcinoma, and attention deficit hyperactivity disorder. GO annotations related to this gene include N-acetylglucosamine-6-sulfatase activity and calcium ion binding. An important paralog of this gene is SULF1.

UniProtKB/Swiss-Prot: SULF2_HUMAN, Q8IWU5
Function: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove
sulfate from the C-6 position of glucosamine within specific subregions of intact heparin

Gene Wiki entry for SULF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SULF2 gene promoter:
         Max1   HFH-3   AML1a   NF-kappaB   FOXI1   Nkx6-1   NF-kappaB2   NF-kappaB1   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SULF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SULF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SULF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.2   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.12-q13.13

SULF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULF2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M046285:  view genomic region     (about GC identifiers)

Start:
46,285,092 bp from pter      End:
46,415,360 bp from pter
Size:
130,269 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SULF2_HUMAN, Q8IWU5 (See protein sequence)
Recommended Name: Extracellular sulfatase Sulf-2 precursor  
Size: 870 amino acids; 100455 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subcellular location: Endoplasmic reticulum (By similarity). Golgi apparatus, Golgi stack (By similarity). Cell
surface (By similarity). Note=Also localized on the cell surface (By similarity)
Sequence caution: Sequence=AAH20962.1; Type=Erroneous initiation; Sequence=BAA86561.2; Type=Erroneous initiation;
Sequence=CAB61349.1; Type=Erroneous initiation;
Secondary accessions: E1P5U6 Q5JYE1 Q6UX86 Q96SG2 Q9H1H0 Q9UJR3 Q9ULH3
Alternative splicing: 2 isoforms:  Q8IWU5-1   Q8IWU5-2   (May be due to a competing acceptor splice site)

Explore the universe of human proteins at neXtProt for SULF2: NX_Q8IWU5

Explore proteomics data for SULF2 at MOPED 

Post-translational modifications:

  • UniProtKB: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in
    prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IWU5

  • 4/19 DME Specific Peptides for SULF2 (Q8IWU5) (see all 19)
     TTPMCCP  NETHNFL  NNNTYWC  GKYLNEY 

    SULF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SULF2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001155313.1  NP_061325.1  NP_940998.2  

    ENSEMBL proteins: 
     ENSP00000353007   ENSP00000418290   ENSP00000417894   ENSP00000418442   ENSP00000410026  
     ENSP00000354662  

    Human Recombinant Protein Products for SULF2: 
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    OriGene Protein Over-expression Lysate for SULF2
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    Novus Biologicals SULF2 Proteins
    Novus Biologicals SULF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SULF2 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space NAS12368295
    GO:0005783endoplasmic reticulum IDA18687675
    GO:0005794Golgi apparatus ----
    GO:0005795Golgi stack IEA--
    GO:0005886plasma membrane ISS--

    SULF2 for ontologies           About GeneDecksing



    SULF2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for SULF2 

    Assay Products for SULF2: 
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    GenScript Custom Assay Services for SULF2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SULF2 
    Cloud-Clone Corp. CLIAs for SULF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR014615 Extracellular_sulfatase
     IPR000917 Sulfatase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR024609 Extracellular_sulfatase_C
     IPR024607 Sulfatase_CS

    Graphical View of Domain Structure for InterPro Entry Q8IWU5

    ProtoNet protein and cluster: Q8IWU5

    1 Blocks protein domain: IPB000917 Sulfatase

    UniProtKB/Swiss-Prot: SULF2_HUMAN, Q8IWU5
    Similarity: Belongs to the sulfatase family


    SULF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SULF2_HUMAN, Q8IWU5
    Function: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove
    sulfate from the C-6 position of glucosamine within specific subregions of intact heparin
    Biophysicochemical properties: pH dependence: Optimum pH is 7.0-8.0;

         Enzyme Numbers (IUBMB): EC 3.1.6.-1 EC 3.1.6.142 EC 3.1.62

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004065arylsulfatase activity IMP19520866
    GO:0005509calcium ion binding IEA--
    GO:0008449N-acetylglucosamine-6-sulfatase activity IMP19520866
    GO:0008484sulfuric ester hydrolase activity ----
         
    SULF2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SULF2:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         14 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Sulf2):
     cellular  craniofacial  digestive/alimentary  embryogenesis  growth/size 
     limbs/digits/tail  mortality/aging  muscle  nervous system  renal/urinary system 
     reproductive system  respiratory system  skeleton  vision/eye 

    SULF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SULF2: Sulf2tm1Clrm Sulf2tm1.1Cpe

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SULF2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SULF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SULF2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SULF2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SULF2
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    hsa-miR-140-5p hsa-miR-3164 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidSULF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SULF2

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): SULF2 (NM_018837)
    Sino Biological Human cDNA Clone for SULF2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SULF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SULF2
    Sirion Biotech Customized lentivirus for stable overexpression of SULF2 
                         Customized lentivirus expression plasmids for stable overexpression of SULF2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SULF2
    Search LifeMap BioReagents cell lines for SULF2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SULF2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for SULF2 (Q8IWU53 ENSP000003530074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOC5O004713I2D: score=4 
    MYCENSP000003672074STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development ISS--
    GO:0002063chondrocyte development ISS--
    GO:0003094glomerular filtration ISS--
    GO:0008152metabolic process ----
    GO:0010575positive regulation vascular endothelial growth factor production ISS--

    SULF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SULF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SULF2

    1 HMDB Compound for SULF2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 Novoseek inferred chemical compound relationships for SULF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparan sulfate 82.4 8 18213582 (2), 17855356 (1), 19822709 (1), 19900405 (1) (see all 6)
    glucosamine 64.7 2 19900405 (1), 16417632 (1)
    heparin 57.8 13 16417632 (5), 15843596 (1), 19822709 (1), 12740361 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about SULF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SULF2 gene (3 alternative transcripts): 
    NM_001161841.1  NM_018837.3  NM_198596.2  

    Unigene Cluster for SULF2:

    Sulfatase 2
    Hs.162016  [show with all ESTs]
    Unigene Representative Sequence: AB033073
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479472 ENST00000359930(uc002xto.3) ENST00000479970 ENST00000484875(uc010zyd.2 uc002xtr.3 uc002xtq.3)
    ENST00000495544 ENST00000467815 ENST00000433632 ENST00000465769 ENST00000474450
    ENST00000463221(uc010ghv.1) ENST00000437955 ENST00000478766 ENST00000361612

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SULF2
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SULF2 (see all 17):
    hsa-miR-140-5p hsa-miR-3164 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidSULF2 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SULF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SULF2
    Clone
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    OriGene clones in human, mouse for SULF2 (see all 23)
    OriGene ORF clones in mouse, rat for SULF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SULF2 (NM_018837)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SULF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SULF2
    Sirion Biotech Customized lentivirus for stable overexpression of SULF2 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SULF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SULF2

    Additional mRNA sequence: 

    AB033073.2 AK074483.1 AK075035.1 AK308829.1 AL133001.1 AY101176.1 AY358461.1 BC020962.1 
    BC073790.1 BC090952.1 BC110538.1 BC110539.1 CR749319.1 

    17 DOTS entries:

    DT.97857313  DT.114458  DT.86849198  DT.40281941  DT.70102985  DT.91750493  DT.100794317  DT.100794319 
    DT.120798865  DT.100794316  DT.91653753  DT.91750494  DT.95337731  DT.95374852  DT.95374856  DT.95374857 
    DT.91951875 

    24/227 AceView cDNA sequences (see all 227):

    AY358461 BE669443 BF058599 BM716602 AA226793 AI633048 BU681789 AL537332 
    AW071058 AA506775 AW591257 BU738151 AI356198 AI694175 BQ002128 CF264920 
    AI362702 NM_198596 BC073790 AW074054 AI423137 BQ181056 CB270607 AA612659 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SULF2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                            -     -                                                                                                         

    ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b
    SP1:                                          
    SP2:              -                           
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for SULF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SULF2 expression in normal human tissues (normalized intensities)      SULF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAACTTTTA
    SULF2 Expression
    About this image


    SULF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Thalamus
             Midbrain dopaminergic-like neurons ( Generation of midbrain dopaminergic, forebrain...
             Septum   
     
     Uncategorized (Uncategorized)    fully expand to see all 5 entries
             PureStem Progenitor SM22
     
     Choroid Plexus (Nervous System)    fully expand to see all 2 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Human Choroid Plexus Endothelial Cells (HCPEC)   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

    See SULF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SULF2

    SOURCE GeneReport for Unigene cluster: Hs.162016

    UniProtKB/Swiss-Prot: SULF2_HUMAN, Q8IWU5
    Tissue specificity: Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart,
    kidney and placenta

        SABiosciences Custom PCR Arrays for SULF2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SULF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SULF2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sulf21 , 5 sulfatase 21, 5 87.99(n)1
    94.48(a)1
      2 (86.31 cM)5
    720431  NM_001252579.11  NP_001239508.11 
     1660730895 
    chicken
    (Gallus gallus)
    Aves SULF21 sulfatase 2 76.79(n)
    87(a)
      419209  XM_417386.3  XP_417386.2 
    lizard
    (Anolis carolinensis)
    Reptilia SULF26
    Uncharacterized protein
    85(a)
    1 ↔ 1
    4(145320417-145439534)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.154522 Xenopus laevis transcribed sequence with weak similarity more 79.76(n)    CB200492.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc556122 similar to sulfatase 2 75.89(n)   393910  BC045403.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sulf16
    Sulfated
    32(a)
    1 → many
    3R(12136264-12164260)
    worm
    (Caenorhabditis elegans)
    Secernentea sul-16
    Putative extracellular sulfatase Sulf-1 homolog
    42(a)
    1 → many
    X(3267295-3270863)


    ENSEMBL Gene Tree for SULF2 (if available)
    TreeFam Gene Tree for SULF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SULF2 gene
    SULF12  GNS2  
    4 SIMAP similar genes for SULF2 using alignment to 6 protein entries:     SULF2_HUMAN (see all proteins):
    SULF1    DKFZp686F13142    GNS    DKFZp686E12166

    SULF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3410 SNPs in SULF2 are shown (see all 3410)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364954
    A breast cancer sample4--see VAR_0364952 D N mis40--------
    VAR_0364944
    A breast cancer sample4--see VAR_0364942 Y H mis40--------
    rs105784381,2
    C--43123531(+) aaaaa-/A/AA  
            
    gaaag
    3 -- int11NA 2
    rs741787531,2
    C--46286153(+) CTCCCAAGA/-  
            
    AAGAA
    3 -- ut311Minor allele frequency- -:0.50NA 2
    rs677486221,2
    C--46286154(+) TCCCA-/AAGA  
            
    AGAAA
    3 -- ut310--------
    rs346331141,2
    C,F--46286155(+) AGAAA-/GAAA  
            
    TGGCC
    3 -- ut316Minor allele frequency- GAAA:0.05NA NS 184
    rs1471162291,2
    --46286219(+) GGGTTC/TTGAAC 3 -- ut310--------
    rs4452191,2
    C,F,A,H--46286239(-) TTTAAG/CTATTG 3 -- ut31 ese327Minor allele frequency- C:0.05EA NA MN NS 2582
    rs1851383551,2
    --46286245(+) TTAAAC/TTACAA 3 -- ut310--------
    rs726462231,2
    C,F--46286307(+) CATTTC/GTTTTC 3 -- ut316Minor allele frequency- G:0.02NS EA 306

    HapMap Linkage Disequilibrium report for SULF2 (46285092 - 46415360 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SULF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678560CNV Deletion23128226
    nsv513547CNV Insertion21212237
    esv2650626CNV Insertion19546169
    nsv3396CNV Insertion18451855
    nsv833995CNV Loss17160897
    nsv469534CNV Loss16826518
    nsv524279CNV Loss19592680
    nsv3397CNV Loss18451855
    dgv1333e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610013    OMIM disorders: --

    10 diseases for SULF2:    About MalaCards
    breast adenocarcinoma    attention deficit hyperactivity disorder    nephrotic syndrome    malignant glioma
    myeloma    hepatocellular carcinoma    adenocarcinoma    lung cancer
    endotheliitis    breast cancer


    SULF2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SULF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 16192265 (2), 18318435 (2), 19086847 (1)

    Genetic Association Database (GAD): SULF2

    Export disorders for SULF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SULF2 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with SULF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. (PubMed id 12368295)1, 2, 3 Morimoto-Tomita M.... Rosen S.D. (2002)
    2. Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. (PubMed id 18937294)1, 4 Lasky-Su J....Faraone S.V. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
    8. HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. (PubMed id 16417632)1, 9 Uchimura K....Rosen S.D. (2006)
    9. HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. (PubMed id 16192265)1, 9 Dai Y....Sanderson R.D. (2005)
    10. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55959 HGNC: 20392 AceView: SULF2 Ensembl:ENSG00000196562 euGenes: HUgn55959
    ECgene: SULF2 H-InvDB: SULF2

    (According to HUGE)
    About This Section
    HUGE: KIAA1247

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SULF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SULF2 gene:
    Search GeneIP for patents involving SULF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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