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SULF2 Gene

protein-coding   GIFtS: 59
GCID: GC20M046285

Sulfatase 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sulfatase 21 2     EC 3.1.6.-3
KIAA12473 5     hSulf-23
HSULF-22     EC 3.1.68
Extracellular Sulfatase Sulf-22     EC 3.1.6.148

External Ids:    HGNC: 203921   Entrez Gene: 559592   Ensembl: ENSG000001965627   OMIM: 6100135   UniProtKB: Q8IWU53   

Export aliases for SULF2 gene to outside databases

Previous GC identifers: GC20M045974 GC20M046924 GC20M046971 GC20M045719 GC20M043027


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SULF2 Gene:
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines
and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove
6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering
binding sites for signaling molecules (Dai et al., 2005 (PubMed 16192265)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SULF2 Gene:
SULF2 (sulfatase 2) is a protein-coding gene. GO annotations related to this gene include N-acetylglucosamine-6-sulfatase activity and calcium ion binding. An important paralog of this gene is SULF1.

UniProtKB/Swiss-Prot: SULF2_HUMAN, Q8IWU5
Function: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove
sulfate from the C-6 position of glucosamine within specific subregions of intact heparin

Gene Wiki entry for SULF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SULF2 gene promoter:
         Max1   HFH-3   AML1a   NF-kappaB   FOXI1   Nkx6-1   NF-kappaB2   NF-kappaB1   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SULF2 promoter sequence
   Search Chromatin IP Primers for SULF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SULF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.2   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.12-q13.13

SULF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULF2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M046285:  view genomic region     (about GC identifiers)

Start:
46,285,092 bp from pter      End:
46,415,360 bp from pter
Size:
130,269 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SULF2_HUMAN, Q8IWU5 (See protein sequence)
Recommended Name: Extracellular sulfatase Sulf-2 precursor  
Size: 870 amino acids; 100455 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Sequence caution: Sequence=AAH20962.1; Type=Erroneous initiation; Sequence=BAA86561.2; Type=Erroneous initiation;
Sequence=CAB61349.1; Type=Erroneous initiation;
Secondary accessions: E1P5U6 Q5JYE1 Q6UX86 Q96SG2 Q9H1H0 Q9UJR3 Q9ULH3
Alternative splicing: 2 isoforms:  Q8IWU5-1   Q8IWU5-2   (May be due to a competing acceptor splice site)

Explore the universe of human proteins at neXtProt for SULF2: NX_Q8IWU5

Explore proteomics data for SULF2 at MOPED

Post-translational modifications: 

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in
    prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)1
  • Ubiquitination2 at Lys694, Lys834, Lys859
  • Glycosylation2 at Asn65, Asn112, Asn132, Asn149, Asn171, Asn198, Asn241, Asn561, Asn608, Asn717,
                                 Asn754, Asn764
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SULF2 (Q8IWU5) (see all 19)
     TTPMCCP  NETHNFL  NNNTYWC  GKYLNEY 


    See SULF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001155313.1  NP_061325.1  NP_940998.2  

    ENSEMBL proteins: 
     ENSP00000353007   ENSP00000418290   ENSP00000417894   ENSP00000418442   ENSP00000410026  
     ENSP00000354662  

    SULF2 Human Recombinant Protein Products:

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    Novus Biologicals SULF2 Proteins
    Novus Biologicals SULF2 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SULF2

     
    Search eBioscience for Proteins for SULF2 

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    LSBio Antibodies in human, mouse, rat for SULF2

    SULF2 Assay Products:

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    Cloud-Clone Corp. ELISAs for SULF2
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    Search eBioscience for ELISAs for SULF2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR014615 Extracellular_sulfatase
     IPR000917 Sulfatase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR024609 Extracellular_sulfatase_C
     IPR024607 Sulfatase_CS

    Graphical View of Domain Structure for InterPro Entry Q8IWU5

    ProtoNet protein and cluster: Q8IWU5

    1 Blocks protein domain: IPB000917 Sulfatase

    UniProtKB/Swiss-Prot: SULF2_HUMAN, Q8IWU5
    Similarity: Belongs to the sulfatase family


    Find genes that share domains with SULF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SULF2_HUMAN, Q8IWU5
    Function: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove
    sulfate from the C-6 position of glucosamine within specific subregions of intact heparin
    Biophysicochemical properties: pH dependence: Optimum pH is 7.0-8.0;

         Enzyme Numbers (IUBMB): EC 3.1.6.-1 EC 3.1.6.142 EC 3.1.62

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004065arylsulfatase activity IMP19520866
    GO:0005509calcium ion binding IEA--
    GO:0008449N-acetylglucosamine-6-sulfatase activity IMP19520866
    GO:0008484sulfuric ester hydrolase activity ----
         
    Find genes that share ontologies with SULF2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SULF2:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         14 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Sulf2):
     cellular  craniofacial  digestive/alimentary  embryogenesis  growth/size/body 
     limbs/digits/tail  mortality/aging  muscle  nervous system  renal/urinary system 
     reproductive system  respiratory system  skeleton  vision/eye 

    Find genes that share phenotypes with SULF2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SULF2: Sulf2tm1Clrm Sulf2tm1.1Cpe

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SULF2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SULF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SULF2

    miRNA
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    miRTarBase miRNAs that target SULF2:
    hsa-mir-193b-3p (MIRT016500)

    Block miRNA regulation of human, mouse, rat SULF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SULF2 (see all 17):
    hsa-miR-140-5p hsa-miR-3164 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidSULF2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SULF2

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    GenScript: all cDNA clones in your preferred vector (see all 3): SULF2 (NM_018837)
    Sino Biological Human cDNA Clone for SULF2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SULF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SULF2
    Addgene plasmids for SULF2 

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SULF2 
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SULF2_HUMAN, Q8IWU5: Endoplasmic reticulum (By similarity). Golgi apparatus, Golgi stack (By similarity). Cell
    surface (By similarity). Note=Also localized on the cell surface (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular5
    plasma membrane4
    golgi apparatus2
    lysosome2
    cytoskeleton1
    cytosol1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space NAS12368295
    GO:0005783endoplasmic reticulum IDA18687675
    GO:0005794Golgi apparatus ----
    GO:0005795Golgi stack IEA--
    GO:0005886plasma membrane ISS--

    Find genes that share ontologies with SULF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SULF2
    Interactions:

        Search GeneGlobe Interaction Network for SULF2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for SULF2 (Q8IWU53 ENSP000003530074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOC5O004713I2D: score=4 
    MYCENSP000003672074STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development ISS--
    GO:0002063chondrocyte development ISS--
    GO:0003094glomerular filtration ISS--
    GO:0008152metabolic process ----
    GO:0010575positive regulation vascular endothelial growth factor production ISS--

    Find genes that share ontologies with SULF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SULF2

    1 HMDB Compound for SULF2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 Novoseek inferred chemical compound relationships for SULF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparan sulfate 82.4 8 18213582 (2), 17855356 (1), 19822709 (1), 19900405 (1) (see all 6)
    glucosamine 64.7 2 19900405 (1), 16417632 (1)
    heparin 57.8 13 16417632 (5), 15843596 (1), 19822709 (1), 12740361 (1) (see all 5)



    Find genes that share compounds with SULF2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SULF2 gene (3 alternative transcripts): 
    NM_001161841.1  NM_018837.3  NM_198596.2  

    Unigene Cluster for SULF2:

    Sulfatase 2
    Hs.162016  [show with all ESTs]
    Unigene Representative Sequence: AB033073
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479472 ENST00000359930(uc002xto.3) ENST00000479970 ENST00000484875(uc010zyd.2 uc002xtr.3 uc002xtq.3)
    ENST00000495544 ENST00000467815 ENST00000433632 ENST00000465769 ENST00000474450
    ENST00000463221(uc010ghv.1) ENST00000437955 ENST00000478766 ENST00000361612

    miRNA
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    Block miRNA regulation of human, mouse, rat SULF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SULF2 (see all 17):
    hsa-miR-140-5p hsa-miR-3164 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidSULF2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SULF2
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    GenScript: all cDNA clones in your preferred vector (see all 3): SULF2 (NM_018837)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SULF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SULF2
    Addgene plasmids for SULF2 
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      QuantiTect SYBR Green Assays in human, mouse, rat SULF2
      QuantiFast Probe-based Assays in human, mouse, rat SULF2

    Additional mRNA sequence: 

    AB033073.2 AK074483.1 AK075035.1 AK308829.1 AL133001.1 AY101176.1 AY358461.1 BC020962.1 
    BC073790.1 BC090952.1 BC110538.1 BC110539.1 CR749319.1 

    17 DOTS entries:

    DT.97857313  DT.114458  DT.86849198  DT.40281941  DT.70102985  DT.91750493  DT.100794317  DT.100794319 
    DT.120798865  DT.100794316  DT.91653753  DT.91750494  DT.95337731  DT.95374852  DT.95374856  DT.95374857 
    DT.91951875 

    Selected AceView cDNA sequences (see all 227):

    BQ004391 BM991910 BQ884082 CB270607 CR611969 CD673642 AI972020 AA716420 
    BQ002128 BU738151 AW074054 AL133001 AI694175 BQ930803 BE869597 BQ650076 
    AI824415 AW591247 BF058599 BM703792 AA494379 AA042886 AW071058 AY358461 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SULF2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                            -     -                                                                                                         

    ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b
    SP1:                                          
    SP2:              -                           
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for SULF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SULF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAACTTTTA
    SULF2 Expression
    About this image


    SULF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Thalamus
             N2/LSB/S/F8/CHIR-induced cells
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
    SULF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SULF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.162016

    UniProtKB/Swiss-Prot: SULF2_HUMAN, Q8IWU5
    Tissue specificity: Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart,
    kidney and placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SULF2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sulf21 , 5 sulfatase 21, 5 87.99(n)1
    94.48(a)1
      2 (86.31 cM)5
    720431  NM_001252579.11  NP_001239508.11 
     1660730895 
    chicken
    (Gallus gallus)
    Aves SULF21 sulfatase 2 76.75(n)
    86.88(a)
      419209  XM_004947050.1  XP_004947107.1 
    lizard
    (Anolis carolinensis)
    Reptilia SULF26
    sulfatase 2
    85(a)
    1 ↔ 1
    4(145320417-145439534)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.154522 Xenopus laevis transcribed sequence with weak similarity more 79.76(n)    CB200492.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc556122 similar to sulfatase 2 75.89(n)   393910  BC045403.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sulf16
    Sulfated
    34(a)
    1 → many
    3R(12136264-12164260)
    worm
    (Caenorhabditis elegans)
    Secernentea sul-16
    Protein SUL-1 (sul-1) mRNA, complete cds
    44(a)
    1 → many
    X(3267295-3270863) WBGene00006308


    ENSEMBL Gene Tree for SULF2 (if available)
    TreeFam Gene Tree for SULF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SULF2 gene
    SULF12  GNS2  
    4 SIMAP similar genes for SULF2 using alignment to 6 protein entries:     SULF2_HUMAN (see all proteins):
    SULF1    DKFZp686F13142    GNS    DKFZp686E12166

    Find genes that share paralogs with SULF2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SULF2 (see all 3410)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364954
    A breast cancer sample4--see VAR_0364952 D N mis40--------
    VAR_0364944
    A breast cancer sample4--see VAR_0364942 Y H mis40--------
    rs105784381,2
    C--43123531(+) aaaaa-/A/AA  
            
    gaaag
    3 -- int11NA 2
    rs741787531,2
    C--46286153(+) CTCCCAAGA/-  
            
    AAGAA
    3 -- ut311Minor allele frequency- -:0.50NA 2
    rs677486221,2
    C--46286154(+) TCCCA-/AAGA  
            
    AGAAA
    3 -- ut310--------
    rs346331141,2
    C,F--46286155(+) AGAAA-/GAAA  
            
    TGGCC
    3 -- ut316Minor allele frequency- GAAA:0.05NA NS 184
    rs1471162291,2
    --46286219(+) GGGTTC/TTGAAC 3 -- ut310--------
    rs4452191,2
    C,F,A,H--46286239(-) TTTAAG/CTATTG 3 -- ut31 ese327Minor allele frequency- C:0.05EA NA MN NS 2582
    rs1851383551,2
    --46286245(+) TTAAAC/TTACAA 3 -- ut310--------
    rs726462231,2
    C,F--46286307(+) CATTTC/GTTTTC 3 -- ut316Minor allele frequency- G:0.02NS EA 306

    HapMap Linkage Disequilibrium report for SULF2 (46285092 - 46415360 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SULF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678560CNV Deletion23128226
    nsv513547CNV Insertion21212237
    esv2650626CNV Insertion19546169
    nsv3396CNV Insertion18451855
    nsv833995CNV Loss17160897
    nsv469534CNV Loss16826518
    nsv524279CNV Loss19592680
    nsv3397CNV Loss18451855
    dgv1333e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SULF2
    DNA2.0 Custom Variant and Variant Library Synthesis for SULF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610013    OMIM disorders: --


    Find genes that share disorders with SULF2           About GenesLikeMe

    1 Novoseek inferred disease relationship for SULF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 16192265 (2), 18318435 (2), 19086847 (1)

    Genetic Association Database (GAD): SULF2

    Export disorders for SULF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SULF2 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with SULF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. (PubMed id 12368295)1, 2, 3 Morimoto-Tomita M.... Rosen S.D. (J. Biol. Chem. 2002)
    2. Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. (PubMed id 18937294)1, 4 Lasky-Su J....Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    8. HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. (PubMed id 16417632)1, 9 Uchimura K....Rosen S.D. (BMC Biochem. 2006)
    9. HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. (PubMed id 16192265)1, 9 Dai Y....Sanderson R.D. (J. Biol. Chem. 2005)
    10. Overexpression of Sulf2 in idiopathic pulmonary fibrosis. (PubMed id 23418199)1 Yue X....Lasky J.A. (Glycobiology 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55959 HGNC: 20392 AceView: SULF2 Ensembl:ENSG00000196562 euGenes: HUgn55959
    ECgene: SULF2 H-InvDB: SULF2

    (According to HUGE)
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    HUGE: KIAA1247

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SULF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SULF2 gene:
    Search GeneIP for patents involving SULF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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