Aliases for SULF1 Gene
External Ids for SULF1 Gene
Previous GeneCards Identifiers for SULF1 Gene
This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for SULF1 Gene
SULF1 (Sulfatase 1) is a Protein Coding gene. Diseases associated with SULF1 include ehlers-danlos syndrome, progeroid type, 2 and mesomelia-synostoses syndrome. GO annotations related to this gene include calcium ion binding and arylsulfatase activity. An important paralog of this gene is SULF2.
UniProtKB/Swiss-Prot for SULF1 Gene
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.