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Aliases for SULF1 Gene

Aliases for SULF1 Gene

  • Sulfatase 1 2 3 5
  • Extracellular Sulfatase Sulf-1 2 3
  • Sulfatase FP 3
  • EC 3.1.6.14 61
  • EC 3.1.6.- 4
  • KIAA1077 4
  • EC 3.1.6 61
  • HSulf-1 4
  • SULF-1 3

External Ids for SULF1 Gene

Previous GeneCards Identifiers for SULF1 Gene

  • GC08P070345
  • GC08P070102
  • GC08P070428
  • GC08P070541
  • GC08P065873
  • GC08P070378

Summaries for SULF1 Gene

Entrez Gene Summary for SULF1 Gene

  • This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for SULF1 Gene

SULF1 (Sulfatase 1) is a Protein Coding gene. Diseases associated with SULF1 include Mesomelia-Synostoses Syndrome and Mesomelia. GO annotations related to this gene include calcium ion binding and arylsulfatase activity. An important paralog of this gene is SULF2.

UniProtKB/Swiss-Prot for SULF1 Gene

  • Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.

Gene Wiki entry for SULF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULF1 Gene

Genomics for SULF1 Gene

Regulatory Elements for SULF1 Gene

Enhancers for SULF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F069486 1.1 Ensembl ENCODE 11.8 +21.5 21505 2.8 PKNOX1 SIN3A RAD21 YY1 ZNF335 FOS ZNF263 ZNF362 JUNB ZNF843 SULF1 GC08M069668
GH08F069491 1 ENCODE 11.3 +26.0 26049 2.4 HDGF SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF143 KLF7 ZNF263 MXD4 SULF1 GC08M069668
GH08F069720 0.7 FANTOM5 9.9 +254.3 254335 0.4 SP3 USF1 YY2 L3MBTL2 HCFC1 NFYC SIX5 MAX USF2 ELF1 TRAM1 SULF1 SLCO5A1 LOC105375889 LOC100101127 GC08P069795
GH08F069120 0.7 FANTOM5 ENCODE 5.1 -345.7 -345688 1.1 JUND POLR2A SULF1 ENSG00000253373 LOC100129096 RNU7-102P
GH08F069130 0.6 FANTOM5 Ensembl 4.8 -336.3 -336281 0.4 SULF1 LOC100129096 TRE-CTC14-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SULF1 on UCSC Golden Path with GeneCards custom track

Promoters for SULF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001441989 1076 2601 RING1 KLF17 FEZF1 ZNF2 ZNF664 POLR2A SCRT2 PRDM10 ZNF600 ZNF263

Genomic Location for SULF1 Gene

Chromosome:
8
Start:
69,466,624 bp from pter
End:
69,660,915 bp from pter
Size:
194,292 bases
Orientation:
Plus strand

Genomic View for SULF1 Gene

Genes around SULF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULF1 Gene

Proteins for SULF1 Gene

  • Protein details for SULF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWU6-SULF1_HUMAN
    Recommended name:
    Extracellular sulfatase Sulf-1
    Protein Accession:
    Q8IWU6
    Secondary Accessions:
    • Q86YV8
    • Q8NCA2
    • Q9UPS5

    Protein attributes for SULF1 Gene

    Size:
    871 amino acids
    Molecular mass:
    101027 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for SULF1 Gene

Selected DME Specific Peptides for SULF1 Gene

Q8IWU6:
  • GYKQCNPR
  • LTGKYVHNHN
  • PIHMEFTN
  • TGYRTAFFGKYLNEYNGSY
  • NNNTYWC
  • GKYLNEY
  • KIWRDTFLVERGKFLRKKEE
  • EEEELQVL
  • NIRPNIILVLTDDQDVELGS
  • RTFAVYLN
  • NETHNFL
  • SGKLRIHKCK
  • YTNNENCSSPSWQA
  • KHGFDYAKDY
  • GSYIPPGW
  • FDIRVPF
  • YTADHGYHIGQFGLVKGKSMPY
  • KNSRFYNYT
  • IVLNIDLAPTILDIAGLD
  • YQTACEQ
  • TTPMCCP
  • PNASQHITPSYNYAPN
  • PGLTCFTHDN
  • PGNRFRTNKK
  • APHGPED

Post-translational modifications for SULF1 Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at Asn 64, Asn 111, Asn 131, Asn 148, Asn 170, Asn 197, Asn 240, Asn 623, Asn 773, and Asn 783
  • Modification sites at PhosphoSitePlus

Domains & Families for SULF1 Gene

Gene Families for SULF1 Gene

Suggested Antigen Peptide Sequences for SULF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWU6

UniProtKB/Swiss-Prot:

SULF1_HUMAN :
  • Belongs to the sulfatase family.
Family:
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with SULF1: view

Function for SULF1 Gene

Molecular function for SULF1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.0-8.0.;
UniProtKB/Swiss-Prot Function:
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.

Enzyme Numbers (IUBMB) for SULF1 Gene

Gene Ontology (GO) - Molecular Function for SULF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004065 arylsulfatase activity IMP 19520866
GO:0005509 calcium ion binding IEA --
GO:0008449 N-acetylglucosamine-6-sulfatase activity IMP 19520866
GO:0008484 sulfuric ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with SULF1: view
genes like me logo Genes that share phenotypes with SULF1: view

Animal Models for SULF1 Gene

MGI Knock Outs for SULF1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SULF1

miRNA for SULF1 Gene

miRTarBase miRNAs that target SULF1

Inhibitory RNA Products

Cell Line Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SULF1 Gene

Localization for SULF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULF1 Gene

Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface. Note=Also localized on the cell surface. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULF1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
lysosome 1

Gene Ontology (GO) - Cellular Components for SULF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space NAS 12368295
GO:0005783 endoplasmic reticulum IDA 18687675
GO:0005794 Golgi apparatus ISS --
GO:0005795 Golgi stack IEA --
GO:0005886 plasma membrane ISS --
genes like me logo Genes that share ontologies with SULF1: view

Pathways & Interactions for SULF1 Gene

SuperPathways for SULF1 Gene

No Data Available

Interacting Proteins for SULF1 Gene

Selected Interacting proteins: Q8IWU6-SULF1_HUMAN for SULF1 Gene via IID

Gene Ontology (GO) - Biological Process for SULF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development ISS --
GO:0001937 negative regulation of endothelial cell proliferation IDA 16778174
GO:0002063 chondrocyte development ISS --
GO:0003094 glomerular filtration ISS --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with SULF1: view

No data available for Pathways by source and SIGNOR curated interactions for SULF1 Gene

Drugs & Compounds for SULF1 Gene

(3) Drugs for SULF1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for SULF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SULF1: view

Transcripts for SULF1 Gene

Unigene Clusters for SULF1 Gene

Sulfatase 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SULF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3:
SP4:
SP5: - - - - -
SP6: - - - - - - - -
SP7: - - - - -
SP8: - - - - - - - - -
SP9:
SP10:
SP11: - -
SP12: - - - - -
SP13: - - - -
SP14: - -
SP15:
SP16:
SP17: -

ExUns: 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:

Relevant External Links for SULF1 Gene

GeneLoc Exon Structure for
SULF1
ECgene alternative splicing isoforms for
SULF1

Expression for SULF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SULF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULF1 Gene

This gene is overexpressed in Artery - Aorta (x8.9), Artery - Coronary (x5.9), and Artery - Tibial (x5.7).

Protein differential expression in normal tissues from HIPED for SULF1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (54.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SULF1 Gene



Protein tissue co-expression partners for SULF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SULF1 Gene:

SULF1

SOURCE GeneReport for Unigene cluster for SULF1 Gene:

Hs.409602

mRNA Expression by UniProt/SwissProt for SULF1 Gene:

Q8IWU6-SULF1_HUMAN
Tissue specificity: Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines.
genes like me logo Genes that share expression patterns with SULF1: view

Primer Products

Orthologs for SULF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULF1 34 35
  • 99.54 (n)
oppossum
(Monodelphis domestica)
Mammalia SULF1 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SULF1 34 35
  • 91.35 (n)
cow
(Bos Taurus)
Mammalia SULF1 34 35
  • 88.55 (n)
rat
(Rattus norvegicus)
Mammalia Sulf1 34
  • 86.96 (n)
mouse
(Mus musculus)
Mammalia Sulf1 34 16 35
  • 86.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SULF1 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves SULF1 34 35
  • 79.67 (n)
lizard
(Anolis carolinensis)
Reptilia SULF1 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sulf1 34
  • 74.68 (n)
Str.10720 34
zebrafish
(Danio rerio)
Actinopterygii sulf1 34 35
  • 68.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sulf1 35
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sul-1 34 35
  • 55.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5614 34
Species where no ortholog for SULF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SULF1 Gene

ENSEMBL:
Gene Tree for SULF1 (if available)
TreeFam:
Gene Tree for SULF1 (if available)

Paralogs for SULF1 Gene

Paralogs for SULF1 Gene

genes like me logo Genes that share paralogs with SULF1: view

Variants for SULF1 Gene

Sequence variations from dbSNP and Humsavar for SULF1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs538017286 Likely benign 69,586,473(+) GCAAT(A/G)GCATC nc-transcript-variant, reference, missense
rs117639561 Benign 69,638,747(+) ATACA(A/G)TGCAC nc-transcript-variant, reference, missense
rs142971465 Benign 69,621,140(+) ACGCT(C/G)GCGGC nc-transcript-variant, reference, missense
rs1001537 -- 69,498,578(-) TTACC(A/G)TCTCT intron-variant
rs10087083 -- 69,609,278(+) gaagt(C/T)gaggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SULF1 Gene

Variant ID Type Subtype PubMed ID
nsv1147654 CNV deletion 26484159
nsv1142694 CNV deletion 24896259
nsv1121689 CNV deletion 24896259
nsv1068714 OTHER inversion 25765185
nsv1027527 CNV gain 25217958
esv3617553 CNV loss 21293372
esv3617551 CNV loss 21293372
esv3617550 CNV gain 21293372
esv3543624 CNV deletion 23714750
esv3448948 CNV insertion 20981092
esv2737142 CNV deletion 23290073
esv2737141 CNV deletion 23290073
esv2282827 CNV deletion 18987734
dgv92n68 CNV loss 17160897
dgv892n27 CNV gain 19166990
dgv12189n54 CNV gain 21841781

Variation tolerance for SULF1 Gene

Residual Variation Intolerance Score: 21.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.60; 56.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SULF1 Gene

Human Gene Mutation Database (HGMD)
SULF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULF1 Gene

Disorders for SULF1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SULF1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mesomelia-synostoses syndrome
  • dominant mesomelic shortness of stature with acral synostoses, umbilical anomalies, and soft palate agenesis
mesomelia
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search SULF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SULF1

Genetic Association Database (GAD)
SULF1
Human Genome Epidemiology (HuGE) Navigator
SULF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SULF1
genes like me logo Genes that share disorders with SULF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULF1 Gene

Publications for SULF1 Gene

  1. Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer. (PMID: 12686563) Lai J. … Shridhar V. (J. Biol. Chem. 2003) 3 4 22 64
  2. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. (PMID: 12368295) Morimoto-Tomita M. … Rosen S.D. (J. Biol. Chem. 2002) 2 3 4 64
  3. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A. … Haiman C.A. (PLoS Genet. 2011) 3 46 64
  4. Common genetic variants and risk for HPV persistence and progression to cervical cancer. (PMID: 20084279) Wang S.S. … Hildesheim A. (PLoS ONE 2010) 3 22 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for SULF1 Gene

Sources for SULF1 Gene

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