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SULF1 Gene

protein-coding   GIFtS: 58
GCID: GC08P070378

Sulfatase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sulfatase 11 2     Sulfatase FP2
KIAA10773 5     EC 3.1.6.-3
HSULF-12     hSulf-13
SULF-12     EC 3.1.68
Extracellular Sulfatase Sulf-12     EC 3.1.6.148

External Ids:    HGNC: 203911   Entrez Gene: 232132   Ensembl: ENSG000001375737   OMIM: 6100125   UniProtKB: Q8IWU63   

Export aliases for SULF1 gene to outside databases

Previous GC identifers: GC08P070345 GC08P070102 GC08P070428 GC08P070541 GC08P065873


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SULF1 Gene:
This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes
6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted
through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be
down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for SULF1 Gene:
SULF1 (sulfatase 1) is a protein-coding gene. Diseases associated with SULF1 include mesomelia, and mesomelia-synostoses syndrome. GO annotations related to this gene include N-acetylglucosamine-6-sulfatase activity and calcium ion binding. An important paralog of this gene is GNS.

UniProtKB/Swiss-Prot: SULF1_HUMAN, Q8IWU6
Function: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove
sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG
(heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes
proliferation, and facilitates apoptosis in response to exogenous stimulation

Gene Wiki entry for SULF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SULF1 gene promoter:
         c-Fos   RFX1   AP-1   FosB   FOXD1   LUN-1   RelA   NF-kappaB   GATA-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SULF1 promoter sequence
   Search Chromatin IP Primers for SULF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SULF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13.1   Ensembl cytogenetic band:  8q13.2   HGNC cytogenetic band: 8q13.1

SULF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULF1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P070378:  view genomic region     (about GC identifiers)

Start:
70,378,859 bp from pter      End:
70,573,150 bp from pter
Size:
194,292 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SULF1_HUMAN, Q8IWU6 (See protein sequence)
Recommended Name: Extracellular sulfatase Sulf-1 precursor  
Size: 871 amino acids; 101027 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Secondary accessions: Q86YV8 Q8NCA2 Q9UPS5

Explore the universe of human proteins at neXtProt for SULF1: NX_Q8IWU6

Explore proteomics data for SULF1 at MOPED

Post-translational modifications: 

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in
    prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)1
  • Glycosylation2 at Asn64, Asn111, Asn131, Asn148, Asn170, Asn197, Asn240, Asn623, Asn773, Asn783
  • Selected DME Specific Peptides for SULF1 (Q8IWU6) (see all 25)
     TTPMCCP  NETHNFL  NNNTYWC  GKYLNEY 


    See SULF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001121676.1  NP_001121677.1  NP_001121678.1  NP_055985.2  

    ENSEMBL proteins: 
     ENSP00000436608   ENSP00000403040   ENSP00000432178   ENSP00000385704   ENSP00000390315  
     ENSP00000431308   ENSP00000436949   ENSP00000431753   ENSP00000434128   ENSP00000260128  

    SULF1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SULF1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR014615 Extracellular_sulfatase
     IPR000917 Sulfatase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR024609 Extracellular_sulfatase_C
     IPR024607 Sulfatase_CS

    Graphical View of Domain Structure for InterPro Entry Q8IWU6

    ProtoNet protein and cluster: Q8IWU6

    1 Blocks protein domain: IPB000917 Sulfatase

    UniProtKB/Swiss-Prot: SULF1_HUMAN, Q8IWU6
    Similarity: Belongs to the sulfatase family


    SULF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SULF1_HUMAN, Q8IWU6
    Function: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove
    sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG
    (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes
    proliferation, and facilitates apoptosis in response to exogenous stimulation
    Biophysicochemical properties: pH dependence: Optimum pH is 7.0-8.0;

         Enzyme Numbers (IUBMB): EC 3.1.6.-1 EC 3.1.6.142 EC 3.1.62

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004065arylsulfatase activity IMP19520866
    GO:0005509calcium ion binding IEA--
    GO:0008449N-acetylglucosamine-6-sulfatase activity IMP19520866
    GO:0008484sulfuric ester hydrolase activity ----
         
    SULF1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SULF1:
     Decreased Wnt reporter activit  Decreased nuclei size in G2M 

         14 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Sulf1):
     cellular  craniofacial  digestive/alimentary  growth/size/body  limbs/digits/tail 
     mortality/aging  muscle  nervous system  normal  renal/urinary system 
     reproductive system  respiratory system  skeleton  vision/eye 

    SULF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SULF1: Sulf1tm1Clrm Sulf1tm1.1Cpe

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SULF1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SULF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SULF1

    miRNA
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    miRTarBase miRNAs that target SULF1:
    hsa-mir-124-3p (MIRT022965), hsa-mir-516a-3p (MIRT005970)

    Block miRNA regulation of human, mouse, rat SULF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SULF1 (see all 88):
    hsa-miR-124* hsa-miR-140-5p hsa-miR-607 hsa-miR-106a hsa-miR-4305 hsa-miR-519a hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSULF1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SULF1

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    PureStem ES-210, Ecto-ntu Progenitor
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SULF1_HUMAN, Q8IWU6: Endoplasmic reticulum (By similarity). Golgi apparatus, Golgi stack (By similarity). Cell
    surface (By similarity). Note=Also localized on the cell surface (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular5
    golgi apparatus4
    plasma membrane4
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space NAS12368295
    GO:0005783endoplasmic reticulum IDA18687675
    GO:0005794Golgi apparatus ISS--
    GO:0005795Golgi stack IEA--
    GO:0005886plasma membrane ISS--

    SULF1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SULF1
    Interactions:

        Search GeneGlobe Interaction Network for SULF1

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development ISS--
    GO:0001937negative regulation of endothelial cell proliferation IDA16778174
    GO:0002063chondrocyte development ISS--
    GO:0003094glomerular filtration ISS--
    GO:0006915apoptotic process IEA--

    SULF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SULF1

    1 HMDB Compound for SULF1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 Novoseek inferred chemical compound relationships for SULF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparan sulfate 63 3 19822709 (1), 20206618 (1), 18213582 (1)
    cisplatin 13.1 3 14699503 (2), 12686563 (1)
    tyrosine 8.76 2 12686563 (1), 19373441 (1)



    SULF1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SULF1 gene (4 alternative transcripts): 
    NM_001128204.1  NM_001128205.1  NM_001128206.1  NM_015170.2  

    Unigene Cluster for SULF1:

    Sulfatase 1
    Hs.409602  [show with all ESTs]
    Unigene Representative Sequence: NM_001128205
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000525061 ENST00000458141(uc003xyd.2 uc003xyg.2 uc003xyh.1 uc003xyi.1 uc003xyj.1)
    ENST00000528286 ENST00000529134 ENST00000402687 ENST00000419716 ENST00000529041
    ENST00000534179 ENST00000525112 ENST00000528783 ENST00000525999 ENST00000531064
    ENST00000526808 ENST00000534088 ENST00000521946 ENST00000528146 ENST00000524731
    ENST00000531512
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SULF1 (see all 88):
    hsa-miR-124* hsa-miR-140-5p hsa-miR-607 hsa-miR-106a hsa-miR-4305 hsa-miR-519a hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSULF1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SULF1
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    GenScript: all cDNA clones in your preferred vector (see all 4): SULF1 (NM_015170)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SULF1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SULF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SULF1
      QuantiTect SYBR Green Assays in human, mouse, rat SULF1
      QuantiFast Probe-based Assays in human, mouse, rat SULF1

    Additional mRNA sequence: 

    AB029000.1 AF545571.1 AK055467.1 AK055607.1 AK074873.1 AK095341.1 AK123744.1 AK307951.1 
    AL136772.1 AY101175.1 BC012997.2 BC068565.1 BX571746.1 

    17 DOTS entries:

    DT.447873  DT.40207888  DT.102842905  DT.91721616  DT.100788507  DT.95170646  DT.100026884  DT.121474721 
    DT.100788510  DT.121474664  DT.100788509  DT.121474657  DT.40213194  DT.91664753  DT.100691139  DT.65284943 
    DT.99932091 

    Selected AceView cDNA sequences (see all 241):

    NM_015170 AI798882 AI273076 AI954124 AL699393 AI866719 AW058297 CA427029 
    CB218911 AW589553 AI680526 AW292332 AW073921 AW778744 BC068565 AA479480 
    CR594815 BM719910 BE019099 BE048765 CA446569 AK055467 AI868538 AI754575 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SULF1 (see all 17)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^
    SP1:                                -     -           -     -     -           -     -                                         -                             -   
    SP2:              -     -     -     -     -           -     -     -           -     -                                         -                             -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                  -     -     -           -     -                                                                           

    ExUns: 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30
    SP1:  -                                                                                                                     
    SP2:  -                                                                                                                     
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for SULF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SULF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTAATAATG
    SULF1 Expression
    About this image


    SULF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 32 entries
             Mononuclear Myocytes Forelimb Dorsal Muscles
     
     Somite (Muscoskeletal System)    fully expand to see all 28 entries
             Mononuclear Myocytes Sacral Primary Hypaxial Myotome
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Late MN Progenitor Cells Motor Neural Progenitor Domain
             Floor plate-like cells
     
     Limb (Muscoskeletal System)    fully expand to see all 5 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle
     
     Brain (Nervous System)
             Late MN Progenitor Cells Motor Neural Progenitor Domain
    SULF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SULF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.409602

    UniProtKB/Swiss-Prot: SULF1_HUMAN, Q8IWU6
    Tissue specificity: Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small
    intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in
    ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SULF1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sulf11 , 5 sulfatase 11, 5 86.38(n)1
    92.87(a)1
      1 (3.35 cM)5
    2407251  NM_001198565.11  NP_001185494.11 
     126924305 
    chicken
    (Gallus gallus)
    Aves SULF11 sulfatase 1 79.67(n)
    85.66(a)
      426312  XM_004939905.1  XP_004939962.1 
    lizard
    (Anolis carolinensis)
    Reptilia SULF16
    sulfatase 1
    86(a)
    1 ↔ 1
    4(31901558-31996907)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.107202 Transcribed sequence with weak similarity to protein more 79.21(n)    141992884 
    zebrafish
    (Danio rerio)
    Actinopterygii sulf11 sulfatase 1 68.88(n)
    73.9(a)
      337298  NM_001003846.1  NP_001003846.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sulf16
    Sulfated
    33(a)
    1 → many
    3R(12136264-12164260)
    worm
    (Caenorhabditis elegans)
    Secernentea sul-11 sul-1 55.14(n)
    52.71(a)
      180619  NM_076159.3  NP_508560.1 


    ENSEMBL Gene Tree for SULF1 (if available)
    TreeFam Gene Tree for SULF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SULF1 gene
    GNS2  SULF22  
    4 SIMAP similar genes for SULF1 using alignment to 9 protein entries:     SULF1_HUMAN (see all proteins):
    DKFZp686F13142    SULF2    ARSK    GNS

    SULF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SULF1 (see all 4122)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105919121,2
    C--66052798(+) ttttt-/T/TT/T
    TT
    /TTTTT
    aagac
    4 -- int11NA 2
    rs1902908921,2
    --70376998(+) TTTTAA/GTGAAA 2 -- us2k10--------
    rs1817856041,2
    --70377052(+) CACTTC/TAAACA 2 -- us2k10--------
    rs14812761,2
    C,F,H--70377131(-) AGAAGC/TTTTAT 2 -- us2k15Minor allele frequency- T:0.01NS EA NA 422
    rs1910181671,2
    --70377143(+) GATTCC/TGCATC 2 -- us2k10--------
    rs779025111,2
    C--70377144(+) ATTCCG/TCATCT 2 -- us2k10--------
    rs1384082201,2
    --70377211(+) ACTACC/TTTAAT 2 -- us2k10--------
    rs1808047251,2
    --70377267(+) ATTTCC/TAGACA 2 -- us2k10--------
    rs600483011,2
    C,F--70377295(+) ACCCCC/TCTCCC 2 -- us2k11Minor allele frequency- T:0.11WA 118
    rs2003771481,2
    --70377311(+) ACAGG-/AAAAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SULF1 (70378859 - 70573150 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SULF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2282827CNV Deletion18987734
    esv2737141CNV Deletion23290073
    esv2737142CNV Deletion23290073
    esv268742CNV Insertion20981092
    dgv92n68CNV Loss17160897
    nsv890992CNV Loss21882294
    nsv890991CNV Loss21882294
    nsv890990CNV Gain21882294
    dgv892n27CNV Gain19166990

    Human Gene Mutation Database (HGMD): SULF1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SULF1
    DNA2.0 Custom Variant and Variant Library Synthesis for SULF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610012    OMIM disorders: --

    Selected diseases for SULF1 (see all 26):    
    About MalaCards
    mesomelia    mesomelia-synostoses syndrome    hypospadias    breast cancer
    malignant pleural mesothelioma    narcolepsy    pancreatic cancer    hepatocellular carcinoma
    ovarian cancer    esophageal squamous cell carcinoma    cervicitis    pancreatitis
    insulin resistance    cervical cancer    myeloma    esophagitis
    squamous cell carcinoma    hypoxia    colorectal cancer    adenocarcinoma


    SULF1 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for SULF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 38.5 1 16762634 (1)
    pancreatic cancer 37.3 9 15817123 (5), 16603650 (2)
    cancer 31.7 19 19373441 (3), 12686563 (2), 20084279 (2), 15817123 (1) (see all 7)
    ovarian cancer 18 2 12686563 (1), 14973553 (1)
    tumors 16.6 15 19086847 (2), 16192265 (2), 15817123 (1), 17363371 (1) (see all 9)
    carcinoma squamous cell 7.34 3 14973553 (2)
    adenocarcinoma 4.71 1 16603650 (1)

    Genetic Association Database (GAD): SULF1
    Human Genome Epidemiology (HuGE) Navigator: SULF1 (4 documents)

    Export disorders for SULF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SULF1 gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with SULF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. (PubMed id 12368295)1, 2, 3 Morimoto-Tomita M.... Rosen S.D. (J. Biol. Chem. 2002)
    2. Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer. (PubMed id 12686563)1, 2, 9 Lai J.... Shridhar V. (J. Biol. Chem. 2003)
    3. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PubMed id 21998595)1, 4 N'Diaye A....Haiman C.A. (PLoS Genet. 2011)
    4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    8. The tumor suppressor function of human sulfatase 1 (SULF1) in carcinogenesis. (PubMed id 19373441)1, 9 Lai J.P....Roberts L.R. (J Gastrointest Cancer 2008)
    9. hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling. (PubMed id 14699503)1, 9 Lai J.P....Roberts L.R. (Gastroenterology 2004)
    10. SULF1 inhibits tumor growth and potentiates the effects of histone deacetylase inhibitors in hepatocellular carcinoma. (PubMed id 16762634)1, 9 Lai J.P....Roberts L.R. (Gastroenterology 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23213 HGNC: 20391 AceView: SULF1 Ensembl:ENSG00000137573 euGenes: HUgn23213
    ECgene: SULF1 H-InvDB: SULF1

    (According to HUGE)
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    HUGE: KIAA1077

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SULF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SULF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SULF1 gene:
    Search GeneIP for patents involving SULF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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