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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SULF1 Gene

protein-coding GIFtS: 57
GCID: GC08P070428

sulfatase 1

Explore 22 diseases affiliated with
SULF1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sulfatase 1¹ ²		Sulfatase FP²
KIAA1077¹ ³ ⁵		EC 3.1.6.-³
SULF-1¹ ²		HSulf-1¹
HSULF-1²		EC 3.1.6⁸
Extracellular Sulfatase Sulf-1²		EC 3.1.6.14⁸

External Ids:	HGNC: 20391¹	Entrez Gene: 23213²	Ensembl: ENSG00000137573⁷	OMIM: 610012⁵	UniProtKB: Q8IWU6³

Export aliases for SULF1 gene to outside databases

Previous GC identifers: GC08P070345 GC08P070102 GC08P070541 GC08P065873

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SULF1:

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and

are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF1, selectively remove 6-O-sulfate

groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for

signaling molecules (Dai et al., 2005 (PubMed 16192265)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SULF1_HUMAN, Q8IWU6

Function: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove

sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan

sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation,

and facilitates apoptosis in response to exogenous stimulation

Gene Wiki entry for SULF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008183.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SULF1 gene promoter:
c-Fos RFX1 AP-1 FosB FOXD1 LUN-1 RelA NF-kappaB GATA-1 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SULF1 promoter sequence

Search SABiosciences Chromatin IP Primers for SULF1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SULF1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13.1 Ensembl cytogenetic band: 8q13.2 HGNC cytogenetic band: 8q13.1

SULF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULF1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P070428: view genomic region (about GC identifiers)

Start:	70,378,859 bp from pter	End:	70,573,150 bp from pter
Size:	194,292 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SULF1_HUMAN, Q8IWU6 (See protein sequence)

Recommended Name: Extracellular sulfatase Sulf-1 precursor

Size: 871 amino acids; 101027 Da

Cofactor: Binds 1 calcium ion per subunit (By similarity)

Subcellular location: Endoplasmic reticulum (By similarity). Golgi apparatus, Golgi stack (By similarity). Cell surface

(By similarity). Note=Also localized on the cell surface (By similarity)

Secondary accessions: Q86YV8 Q8NCA2 Q9UPS5

Explore the universe of human proteins at neXtProt for SULF1: NX_Q8IWU6

Post-translational modifications:

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes

and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IWU6

4/25 DME Specific Peptides for SULF1 (Q8IWU6) (see all 25)

TTPMCCP

NETHNFL

NNNTYWC

GKYLNEY

SULF1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001121676.1 NP_001121677.1 NP_001121678.1 NP_055985.2

ENSEMBL proteins:

ENSP00000436608 ENSP00000403040 ENSP00000432178 ENSP00000385704 ENSP00000390315

ENSP00000431308 ENSP00000436949 ENSP00000431753 ENSP00000434128 ENSP00000260128

Human Recombinant Protein Products:

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SULF1 OriGene Custom Protein Services for SULF1
	GenScript Custom Purified and Recombinant Proteins Services for SULF1
	Novus Biologicals SULF1 Protein Novus Biologicals SULF1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SULF1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	NAS	12368295
GO:0005783	endoplasmic reticulum	IDA	18687675
GO:0005794	Golgi apparatus	ISS	--
GO:0005795	Golgi stack	IEA	--
GO:0005886	plasma membrane	ISS	--

SULF1 for ontologies About GeneDecksing

SULF1 Antibody Products:

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	Novus Biologicals SULF1 Antibodies
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	Uscn Antibodies for SULF1
	ThermoFisher Antibodies for SULF1

Assay Products for SULF1:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for SULF1
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	Uscn ELISAs and CLIAs for SULF1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SULF1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR014615 Extracellular_sulfatase

IPR000917 Sulfatase

IPR017849 Alkaline_Pase-like_a/b/a

IPR024609 Extracellular_sulfatase_C

IPR024607 Sulfatase_CS

Graphical View of Domain Structure for InterPro Entry Q8IWU6

ProtoNet protein and cluster: Q8IWU6

1 Blocks protein family: IPB000917 Sulfatase

UniProtKB/Swiss-Prot: SULF1_HUMAN, Q8IWU6

Similarity: Belongs to the sulfatase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SULF1_HUMAN, Q8IWU6

Function: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove

sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan

sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation,

and facilitates apoptosis in response to exogenous stimulation

Biophysicochemical properties: pH dependence: Optimum pH is 7.0-8.0;

Enzyme Numbers (IUBMB): EC 3.1.6.-¹ EC 3.1.6.14² EC 3.1.6²

miRNA Products:		miRTarBase miRNAs that target SULF1: hsa-mir-516a-3p (MIRT005970)

		OriGene 3'-UTR Clone (see all 4): SULF1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SULF1
		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate SULF1 (see all 88):
		hsa-miR-124* hsa-miR-140-5p hsa-miR-607 hsa-miR-106a hsa-miR-4305 hsa-miR-519a hsa-miR-93 hsa-miR-3613-3p

		SwitchGear 3'UTR luciferase reporter plasmid: SULF1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SULF1 (see all 7) OriGene shRNA RFP: SULF1 OriGene siRNA: SULF1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SULF1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SULF1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SULF1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SULF1 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): SULF1 (NM_015170)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SULF1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SULF1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SULF1
		LifeMap BioReagents: cell line associated with SULF1: PureStem ES-210, Ecto-ntu Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULF1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004065	arylsulfatase activity	IMP	19520866
GO:0005509	calcium ion binding	IEA	--
GO:0008449	N-acetylglucosamine-6-sulfatase activity	IMP	19520866

SULF1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for SULF1:

Decreased Wnt reporter activit

Decreased nuclei size in G2M

Animal Models:
Mouse knock-outs for SULF1: Sulf1^tm1Clrm Sulf1^tm1.1Cpe
14 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Sulf1):

cellular	craniofacial	digestive/alimentary	growth/size	limbs/digits/tail
mortality/aging	muscle	nervous system	normal	renal/urinary system
reproductive system	respiratory system	skeleton	vision/eye

SULF1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SULF1

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001822	kidney development	ISS	--
GO:0001937	negative regulation of endothelial cell proliferation	IDA	16778174
GO:0002063	chondrocyte development	ISS	--
GO:0003094	glomerular filtration	ISS	--
GO:0006915	apoptotic process	IEA	--

SULF1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SULF1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SULF1

1 HMDB Compound for SULF1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

3 Novoseek chemical compound relationships for SULF1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
heparan sulfate	63	3	19822709 (1), 20206618 (1), 18213582 (1)
cisplatin	13.1	3	14699503 (2), 12686563 (1)
tyrosine	8.76	2	12686563 (1), 19373441 (1)

Search CenterWatch for drugs/clinical trials and news about SULF1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SULF1 gene (4 alternative transcripts):

NM_001128204.1 NM_001128205.1 NM_001128206.1 NM_015170.2

Unigene Cluster for SULF1:

Sulfatase 1

Hs.409602 [show with all ESTs]

Unigene Representative Sequence: NM_001128205

18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):

ENST00000525061 ENST00000458141(uc003xyd.2 uc003xyg.2 uc003xyh.1 uc003xyi.1 uc003xyj.1)

ENST00000528286 ENST00000529134 ENST00000402687 ENST00000419716 ENST00000529041

ENST00000534179 ENST00000525112 ENST00000528783 ENST00000525999 ENST00000531064

ENST00000526808 ENST00000534088 ENST00000521946 ENST00000528146 ENST00000524731

ENST00000531512

miRNA Products:		OriGene 3'-UTR Clone (see all 4): SULF1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SULF1
		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate SULF1 (see all 88):
		hsa-miR-124* hsa-miR-140-5p hsa-miR-607 hsa-miR-106a hsa-miR-4305 hsa-miR-519a hsa-miR-93 hsa-miR-3613-3p

		SwitchGear 3'UTR luciferase reporter plasmid: SULF1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SULF1 (see all 7) OriGene shRNA RFP: SULF1 OriGene siRNA: SULF1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SULF1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SULF1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SULF1 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): SULF1 (NM_015170)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SULF1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SULF1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SULF1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SULF1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SULF1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SULF1

Additional cDNA sequence:

AB029000.1 AF545571.1 AK055467.1 AK055607.1 AK074873.1 AK095341.1 AK123744.1 AK307951.1

AL136772.1 AY101175.1 BC012997.2 BC068565.1 BX571746.1

17 DOTS entries:

DT.447873 DT.40207888 DT.102842905 DT.91721616 DT.100788507 DT.95170646 DT.100026884 DT.121474721

DT.100788510 DT.121474664 DT.100788509 DT.121474657 DT.40213194 DT.91664753 DT.100691139 DT.65284943

DT.99932091

24/241 AceView cDNA sequences (see all 241):

CA413517 AI218456 AI580231 BE295661 AW262719 AI584017 AI637946 BU738948

AI972834 AI754575 AF545571 AK055467 AI168672 CA446569 AI868538 BE048765

BE019099 CR594815 AA479480 AW778744 AW073921 CB218911 AW292332 AW589553

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for SULF1 (see all 17) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	^	10	^	11	^	12a	·	12b	·	12c	^	13	^
SP1:											-		-				-		-		-				-		-														-										-
SP2:					-		-		-		-		-				-		-		-				-		-														-										-
SP3:
SP4:
SP5:																	-		-		-				-		-

ExUns:	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b	^	21a	·	21b	^	22	^	23	^	24	^	25	^	26	^	27	^	28a	·	28b	^	29	^	30
SP1:	-
SP2:	-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SULF1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SULF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTAATAATG

About this image

SULF1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/35 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 35)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Forelimb Dorsal Muscles

Mononuclear Myocytes

Skeletal Muscle

Limb

Forelimb Ventral Muscles

Mononuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Dorsal Muscle

Mononuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Ventral Muscle

Mononuclear Myocytes

Skeletal Muscle

Thoracic Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Thoracic Epaxial Myotome

Myoblasts

Skeletal Muscle

Somite

Cervical Dorsomedial Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Somite

Cervical Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Epaxial Myotome

Myoblasts

Skeletal Muscle

Somite

Cervical Hypaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 9 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

See SULF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SULF1

SOURCE GeneReport for Unigene cluster: Hs.409602

UniProtKB/Swiss-Prot: SULF1_HUMAN, Q8IWU6

Tissue specificity: Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small

intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian

carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines

SABiosciences Custom PCR Arrays for SULF1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SULF1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SULF1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SULF1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SULF1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULF1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SULF1 gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SULF1¹	sulfatase 1	80.35(n) 86.62(a)		426312 XM_003640824.1 XP_003640872.1
lizard (Anolis carolinensis)	Reptilia	SULF1⁶	--	86(a)	1 ↔ 1	4(31950638-31996907)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.10720²	Transcribed sequence with weak similarity to protein more	79.21(n)		141992884
zebrafish (Danio rerio)	Actinopterygii	sulf1¹	sulfatase 1	69.28(n) 74.82(a)		337298 NM_001003846.1 NP_001003846.1
fruit fly (Drosophila melanogaster)	Insecta	Sulf1¹	Sulfated	51.78(n) 47.71(a)		53437 NM_080248.2 NP_524987.1
worm (Caenorhabditis elegans)	Secernentea	sul-1¹	Protein SUL-1	54.02(n) 51.11(a)		180619 NM_076159.2 NP_508560.1
E. coli (Escherichia coli)	Gamma proteobacteria	yidJ⁶	predicted sulfatase/phosphatase	16(a)	possible ortholog	Chromosome(3854934-3856427)

ENSEMBL Gene Tree for SULF1 (if available)
TreeFam Gene Tree for SULF1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SULF1 gene

GNS² SULF2² ARSK²

4 SIMAP similar genes for SULF1 using alignment to 9 protein entries: SULF1_HUMAN (see all proteins):

DKFZp686F13142 SULF2 ARSK GNS

SULF1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5892190^1,2	C,	--	70376918(+)	`TTGTA-/TTTTTT`	2	--	us2k¹		0	--	--	--	--
rs33914185^1,2	C	--	70376920(+)	`TTTTT-/TATTTT`	2	--	us2k¹		0	--	--	--	--
rs190290892^1,2		--	70376998(+)	`TTTTAA/GTGAAA`	2	--	us2k¹		0	--	--	--	--
rs181785604^1,2		--	70377052(+)	`CACTTC/TAAACA`	2	--	us2k¹		0	--	--	--	--
rs1481276^1,2	C,F,H,	--	70377131(-)	`AGAAGC/TTTTAT`	2	--	us2k¹		5		NS EA NA	422
rs191018167^1,2		--	70377143(+)	`GATTCC/TGCATC`	2	--	us2k¹		0	--	--	--	--
rs77902511^1,2	C	--	70377144(+)	`ATTCCG/TCATCT`	2	--	us2k¹		0	--	--	--	--
rs138408220^1,2		--	70377211(+)	`ACTACC/TTTAAT`	2	--	us2k¹		0	--	--	--	--
rs180804725^1,2		--	70377267(+)	`ATTTCC/TAGACA`	2	--	us2k¹		0	--	--	--	--
rs60048301^1,2	C,F,	--	70377295(+)	`ACCCCC/TCTCCC`	2	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for SULF1 (70378859 - 70573150 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SULF1
1 CNV: 53438
1 Indel: 47579
Human Gene Mutation Database (HGMD): SULF1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SULF1 for disorders           About GeneDecksing

OMIM gene information: 610012    OMIM disorders: --

20/22 diseases for SULF1 (see all 22):    About MalaCards

mesomelia-synostoses syndrome mesomelia synostoses syndrome esophageal squamous cell carcinoma

squamous cell carcinoma hepatocellular carcinoma ovarian cancer pancreatic cancer

carcinoma ovarian carcinoma cervical cancer esophagitis

cervicitis pancreatitis hepatocellular cancer gastric cancer

colorectal cancer breast cancer myeloma hypoxia

7 Novoseek disease relationships for SULF1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatocellular carcinoma	38.5	1	16762634 (1)
pancreatic cancer	37.3	9	15817123 (5), 16603650 (2)
cancer	31.7	19	19373441 (3), 12686563 (2), 20084279 (2), 15817123 (1) (see all 7)
ovarian cancer	18	2	12686563 (1), 14973553 (1)
tumors	16.6	15	19086847 (2), 16192265 (2), 15817123 (1), 17363371 (1) (see all 9)
carcinoma squamous cell	7.34	3	14973553 (2)
adenocarcinoma	4.71	1	16603650 (1)

Human Genome Epidemiology (HuGE) Navigator: SULF1 (4 documents)

Export disorders for SULF1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SULF1 gene, integrated from 9 sources (see all 54):
(articles sorted by number of sources associating them with SULF1)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. (PubMed id 12368295)^{1, 2, 3} Morimoto-Tomita M.... Rosen S.D. (2002)
Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer. (PubMed id 12686563)^{1, 2, 9} Lai J.... Shridhar V. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)^{1, 2} Kikuno R....Ohara O. (1999)
The tumor suppressor function of human sulfatase 1 (S ULF1) in carcinogenesis. (PubMed id 19373441)^{1, 9} Lai J.P....Roberts L.R. (2008)
hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling. (PubMed id 14699503)^{1, 9} Lai J.P....Roberts L.R. (2004)
Loss of HSulf-1 expression enhances autocrine signaling mediated by amphiregulin in breast cancer. (PubMed id 17363371)^{1, 9} Narita K....Shridhar V. (2007)
Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer. (PubMed id 15817123)^{1, 9} Li J....Friess H. (2005)
Promoter hypermethylation correlates with the Hsulf-1 silencing in human breast and gastric cancer. (PubMed id 19006069)^{1, 9} Chen Z....Zhou H.M. (2009)
Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage. (PubMed id 18507859)^{1, 9} Otsuki S....Lotz M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23213	HGNC: 20391	AceView: SULF1	Ensembl:ENSG00000137573	euGenes: HUgn23213
ECgene: SULF1	H-InvDB: SULF1

(According to HUGE)
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HUGE: KIAA1077

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SULF1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SULF1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SULF1 gene:
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GeneCards and IP:
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