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SUGT1 Gene

protein-coding   GIFtS: 57
GCID: GC13P053226

SGT1, Suppressor Of G2 Allele Of SKP1 (S. Cerevisiae)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SGT1, Suppressor Of G2 Allele Of SKP1 (S. Cerevisiae)1 2     Suppressor Of G2 Allele Of SKP1 Homolog2
SGT12 5     Suppressor Of G2 Allele Of SKP1, S. Cerevisiae, Homolog Of2
Putative 40-6-3 Protein2     Sgt13
SGT1B Protein2     Protein 40-6-33

External Ids:    HGNC: 169871   Entrez Gene: 109102   Ensembl: ENSG000001654167   OMIM: 6040985   UniProtKB: Q9Y2Z03   

Export aliases for SUGT1 gene to outside databases

Previous GC identifers: GC13P047221 GC13P052163 GC13P051024 GC13P051025 GC13P052124 GC13P033941


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SUGT1 Gene:
This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and
required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar
functions. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Aug 2008)

GeneCards Summary for SUGT1 Gene:
SUGT1 (SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)) is a protein-coding gene. Diseases associated with SUGT1 include polydactyly, and colorectal cancer.

UniProtKB/Swiss-Prot: SUGT1_HUMAN, Q9Y2Z0
Function: May play a role in ubiquitination and subsequent proteasomal degradation of target proteins

Gene Wiki entry for SUGT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUGT1 gene promoter:
         AML1a   STAT5A   LCR-F1   FOXL1   HEN1   IRF-2   GATA-6   FOXJ2 (long isoform)   FOXJ2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SUGT1 promoter sequence
   Search Chromatin IP Primers for SUGT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUGT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3   Ensembl cytogenetic band:  13q14.3   HGNC cytogenetic band: 13q14.3

SUGT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUGT1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P053226:  view genomic region     (about GC identifiers)

Start:
53,226,831 bp from pter      End:
53,275,044 bp from pter
Size:
48,214 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SUGT1_HUMAN, Q9Y2Z0 (See protein sequence)
Recommended Name: Suppressor of G2 allele of SKP1 homolog  
Size: 365 amino acids; 41024 Da
Subunit: Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts
with S100A6. Interacts with HSP90
1 PDB 3D structure from and Proteopedia for SUGT1:
1RL1 (3D)    
Secondary accessions: A2A303 Q5JAK5 Q5TAM6 Q6VXY6
Alternative splicing: 2 isoforms:  Q9Y2Z0-1   Q9Y2Z0-2   

Explore the universe of human proteins at neXtProt for SUGT1: NX_Q9Y2Z0

Explore proteomics data for SUGT1 at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to
    disruption of the SUGT1-HSP90 complex1
  • Ubiquitination2 at Lys256, Lys267, Lys274, Lys325, Lys349
  • Modification sites at PhosphoSitePlus

  • See SUGT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001124384.1  NP_006695.1  

    ENSEMBL proteins: 
     ENSP00000367208   ENSP00000308067   ENSP00000443521  
    Reactome Protein details: Q9Y2Z0

    SUGT1 Human Recombinant Protein Products:

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    Novus Biologicals SUGT1 Proteins
    Novus Biologicals SUGT1 Lysates
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    ProSpec Recombinant Protein for SUGT1
    Cloud-Clone Corp. Proteins for SUGT1

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    Cloud-Clone Corp. ELISAs for SUGT1
    Cloud-Clone Corp. CLIAs for SUGT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR011990 TPR-like_helical
     IPR007699 SGS
     IPR008978 HSP20-like_chaperone
     IPR007052 CS_dom
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y2Z0

    ProtoNet protein and cluster: Q9Y2Z0

    1 Blocks protein domain: IPB007052 CS domain

    UniProtKB/Swiss-Prot: SUGT1_HUMAN, Q9Y2Z0
    Domain: The CS domain mediates interaction with HSP90
    Similarity: Belongs to the SUGT1 family
    Similarity: Contains 1 CS domain
    Similarity: Contains 1 SGS domain
    Similarity: Contains 3 TPR repeats


    SUGT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUGT1_HUMAN, Q9Y2Z0
    Function: May play a role in ubiquitination and subsequent proteasomal degradation of target proteins

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    SUGT1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SUGT1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SUGT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SUGT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUGT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUGT1

    miRNA
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    miRTarBase miRNAs that target SUGT1:
    hsa-mir-34a-5p (MIRT025348)

    Block miRNA regulation of human, mouse, rat SUGT1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SUGT1:
    hsa-miR-376b hsa-miR-376a
    SwitchGear 3'UTR luciferase reporter plasmidSUGT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SUGT1
    Predesigned siRNA for gene silencing in human, mouse, rat SUGT1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): SUGT1 (NM_001130912)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUGT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUGT1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUGT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SUGT1_HUMAN, Q9Y2Z0: Cytoplasm. Nucleus. Note=Translocates to the nucleus upon heat shock, requiring S100A6
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex TAS10445024
    GO:0000776kinetochore TAS10445024
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    SUGT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SUGT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    NOD pathway0.33
    NOD-like receptor signaling pathway0.37
    Inflammasomes0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SUGT1
        NOD pathway

    1 Reactome Pathway for SUGT1
        The NLRP3 inflammasome


    1 Kegg Pathway  (Kegg details for SUGT1):
        NOD-like receptor signaling pathway


    SUGT1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SUGT1: 
              Antiviral Response in human mouse rat
              Inflammasomes in human mouse rat
              Antibacterial Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SUGT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SUGT1 (Q9Y2Z01, 2, 3 ENSP000003672084) via UniProtKB, MINT, STRING, and/or I2D (see all 900)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48396 I2D: score=2 
    HSP90AA1P079002, 3, ENSP000003351534MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000335153
    HSP90B1P146252, 3, ENSP000002997674MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000299767
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    KPNB1Q149742, ENSP000002901584MINT-7945693 MINT-7947479 STRING: ENSP00000290158
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis TAS10445024
    GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS--
    GO:0045087innate immune response TAS--

    SUGT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SUGT1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SUGT1 gene (2 alternative transcripts): 
    NM_001130912.1  NM_006704.3  

    Unigene Cluster for SUGT1:

    SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
    Hs.281902  [show with all ESTs]
    Unigene Representative Sequence: NM_001130912
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483074 ENST00000343788 ENST00000310528 ENST00000609175 ENST00000535397(uc001vhc.2 uc001vhb.2 uc010thb.1)

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate SUGT1:
    hsa-miR-376b hsa-miR-376a
    SwitchGear 3'UTR luciferase reporter plasmidSUGT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SUGT1
    Predesigned siRNA for gene silencing in human, mouse, rat SUGT1
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    GenScript: all cDNA clones in your preferred vector (see all 2): SUGT1 (NM_001130912)
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    Primer
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    OriGene qPCR primer pairs and template standards for SUGT1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SUGT1
      QuantiTect SYBR Green Assays in human, mouse, rat SUGT1
      QuantiFast Probe-based Assays in human, mouse, rat SUGT1

    Additional mRNA sequence: 

    AF132856.1 AJ344097.1 AK291402.1 AK292128.1 AK302363.1 AY271314.1 AY321358.1 BC000911.1 
    BT009798.1 

    13 DOTS entries:

    DT.100780457  DT.65284024  DT.97854428  DT.100731627  DT.95161781  DT.95161797  DT.97854424  DT.120761272 
    DT.120761284  DT.120761294  DT.40121249  DT.92451041  DT.97854425 

    Selected AceView cDNA sequences (see all 212):

    BC000911 BQ689179 BT009798 AI282285 BM839833 BI826084 BQ896597 BM978471 
    AA773604 BM849743 BU176954 BQ686395 AI800098 CA748563 AF132856 BQ673377 
    CA495287 AA704143 BU173965 BM558644 BQ685685 CA842003 CK300334 BM549579 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SUGT1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                    -                                                               
    SP2:                                                                                    
    SP3:                                                                                    


    ECgene alternative splicing isoforms for SUGT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SUGT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAAATCCT
    SUGT1 Expression
    About this image

    SUGT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUGT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.281902
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SUGT1: 
              Antiviral Response in human mouse rat
              Inflammasomes in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SUGT1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUGT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUGT1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sugt11 , 5 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) less1, 5 86.58(n)1
    87.62(a)1
      14 (42.72 cM)5
    679551  NM_026474.51  NP_080750.11 
     795876915 
    chicken
    (Gallus gallus)
    Aves SUGT11 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) less 76.16(n)
    77.85(a)
      418827  NM_001030823.2  NP_001025994.2 
    lizard
    (Anolis carolinensis)
    Reptilia SUGT16
    SGT1, suppressor of G2 allele of SKP1 (S. cerevisi...
    69(a)
    1 ↔ 1
    3(70777842-70809909)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.252402 Xenopus laevis transcribed sequence with weak similarity to protein refNP_006695.1 (H.sapiens) suppressor of G2 allele of SKP1 [Homo sapiens] less 76.56(n)    CD302381.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd45a022 Transcribed sequence with moderate similarity to protein refNP_006695.1 (H.sapiens) suppressor of G2 allele of SKP1 [Homo sapiens] less 74.81(n)    57057639 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sgt11 suppressor-of-G2-allele-of-skp1 53.45(n)
    47.7(a)
      40982  NM_141526.4  NP_649783.2 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_D1054.31 CELE_D1054.3 52.15(n)
    40.32(a)
      179494  NM_073350.4  NP_505751.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SGT16
    Cochaperone protein; regulates activity of adenyly...
    23(a)
    1 ↔ 1
    XV(432186-433373) YOR057W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SGT1B1 SGT1B 50.5(n)
    40.12(a)
      826728  NM_117197.3  NP_192865.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g06245001 Os01g0624500 51.79(n)
    41.96(a)
      4326682  NM_001050155.1  NP_001043620.1 


    ENSEMBL Gene Tree for SUGT1 (if available)
    TreeFam Gene Tree for SUGT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SUGT1 gene
    1 SIMAP similar gene for SUGT1 using alignment to 2 protein entries:     SUGT1_HUMAN (see all proteins):
    OK/SW-cl.41

    SUGT1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SUGT1
    PGOHUM00000238672 PGOHUM00000237985


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SUGT1 (see all 744)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1403822121,2
    C--33959655(+) TTAAA-/AAGAGAAT 2 -- cds10--------
    rs2009872431,2
    --33962395(+) TTTTT-/TCTTTTT 2 -- int10--------
    rs2016542141,2
    --33962396(+) TTTTT-/CTTTTT 2 -- int10--------
    rs355370471,2
    C--33970163(+) AAAAAA/-GAGAG 2 -- int11Minor allele frequency- -:0.00NA 2
    rs781050291,2
    C--33970177(+) AAAAAG/AAGAGA 2 -- int11Minor allele frequency- A:0.50NA 2
    rs357630081,2
    C--33970719(+) TGGGG-/GTGTCT 2 -- int12Minor allele frequency- G:0.00NA CSA 4
    rs800113021,2
    C--33972749(+) TTTTT-/GGTTCT 2 -- int10--------
    rs359287011,2
    C--33975704(+) AATCA-/TTTTTT 2 -- int10--------
    rs1169159491,2
    F--34162467(+) TAACCG/AGAGCA 2 -- us2k11Minor allele frequency- A:0.02EA 120
    rs14367291,2
    C,F,A,H--34162541(-) tggctA/Gctcct 2 -- us2k114Minor allele frequency- G:0.03MN NA WA CSA EA 560

    HapMap Linkage Disequilibrium report for SUGT1 (53226831 - 53275044 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SUGT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv900088CNV Loss21882294
    nsv819201CNV Gain19587683
    nsv820041CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604098    OMIM disorders: --

    4 diseases for SUGT1:    
    About MalaCards
    polydactyly    colorectal cancer    lung cancer    malaria


    SUGT1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SUGT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    plant diseases 77.2 3 11847308 (1), 14761955 (1), 12456004 (1)


    Export disorders for SUGT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUGT1 gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with SUGT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. (PubMed id 10445024)1, 2, 3 Kitagawa K.... Hieter P. (Mol. Cell 1999)
    2. Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain. (PubMed id 14761955)1, 2, 9 Lee Y.-T....Chazin W.J. (J. Biol. Chem. 2004)
    3. Identification of a novel splice variant: human SGT1B (SUGT1B). (PubMed id 15018354)1, 2, 9 Niikura Y. and Kitagawa K. (DNA Seq. 2003)
    4. Nuclear translocation of Sgt1 depends on its phosphorylation state. (PubMed id 21864708)1, 2 Prus W.... Filipek A. (Int. J. Biochem. Cell Biol. 2011)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    8. Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. (PubMed id 12746458)1, 2 Nowotny M....Kuznicki J. (J. Biol. Chem. 2003)
    9. Overexpression of SUGT1 in human colorectal cancer and its clinicopathological significance. (PubMed id 20126976)1, 9 Iwatsuki M....Mori M. (Int. J. Oncol. 2010)
    10. 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation. (PubMed id 16501598)1, 9 Niikura Y....Kitagawa K. (Oncogene 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10910 HGNC: 16987 AceView: SUGT1 Ensembl:ENSG00000165416 euGenes: HUgn10910
    ECgene: SUGT1 Kegg: 10910 H-InvDB: SUGT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SUGT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SUGT1 gene:
    Search GeneIP for patents involving SUGT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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