Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUGT1 Gene

protein-coding   GIFtS: 56
GCID: GC13P053226

SGT1, Suppressor Of G2 Allele Of SKP1 (S. Cerevisiae)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SGT1, Suppressor Of G2 Allele Of SKP1 (S. Cerevisiae)1 2     Suppressor Of G2 Allele Of SKP1 Homolog2
SGT12     Suppressor Of G2 Allele Of SKP1, S. Cerevisiae, Homolog Of2
Putative 40-6-3 Protein2     Sgt13
SGT1B Protein2     Protein 40-6-33

External Ids:    HGNC: 169871   Entrez Gene: 109102   Ensembl: ENSG000001654167   OMIM: 6040985   UniProtKB: Q9Y2Z03   

Export aliases for SUGT1 gene to outside databases

Previous GC identifers: GC13P047221 GC13P052163 GC13P051024 GC13P051025 GC13P052124 GC13P033941


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SUGT1 Gene:
This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and
required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar
functions. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Aug 2008)

GeneCards Summary for SUGT1 Gene: 
SUGT1 (SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)) is a protein-coding gene. Diseases associated with SUGT1 include polydactyly, and colorectal cancer, and among its related super-pathways are NOD1/2 Signaling Pathway and The NLRP3 inflammasome.

UniProtKB/Swiss-Prot: SUGT1_HUMAN, Q9Y2Z0
Function: May play a role in ubiquitination and subsequent proteasomal degradation of target proteins

Gene Wiki entry for SUGT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUGT1 gene promoter:
         AML1a   STAT5A   LCR-F1   FOXL1   HEN1   IRF-2   GATA-6   FOXJ2 (long isoform)   FOXJ2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SUGT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SUGT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUGT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3   Ensembl cytogenetic band:  13q14.3   HGNC cytogenetic band: 13q12.2-q13.3

SUGT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUGT1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P053226:  view genomic region     (about GC identifiers)

Start:
53,226,831 bp from pter      End:
53,262,433 bp from pter
Size:
35,603 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SUGT1_HUMAN, Q9Y2Z0 (See protein sequence)
Recommended Name: Suppressor of G2 allele of SKP1 homolog  
Size: 365 amino acids; 41024 Da
Subunit: Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts
with S100A6. Interacts with HSP90
Subcellular location: Cytoplasm. Nucleus. Note=Translocates to the nucleus upon heat shock, requiring S100A6
1 PDB 3D structure from and Proteopedia for SUGT1:
1RL1 (3D)    
Secondary accessions: A2A303 Q5JAK5 Q5TAM6 Q6VXY6
Alternative splicing: 2 isoforms:  Q9Y2Z0-1   Q9Y2Z0-2   

Explore the universe of human proteins at neXtProt for SUGT1: NX_Q9Y2Z0

Explore proteomics data for SUGT1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to
    disruption of the SUGT1-HSP90 complex
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2Z0

  • SUGT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SUGT1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001124384.1  NP_006695.1  

    ENSEMBL proteins: 
     ENSP00000367208   ENSP00000308067   ENSP00000443521  
    Reactome Protein details: Q9Y2Z0
    Human Recombinant Protein Products for SUGT1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SUGT1
    OriGene Protein Over-expression Lysate for SUGT1
    OriGene MassSpec for SUGT1 
    OriGene Custom Protein Services for SUGT1
    GenScript Custom Purified and Recombinant Proteins Services for SUGT1
    Novus Biologicals SUGT1 Proteins
    Novus Biologicals SUGT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SUGT1
    Cloud-Clone Corp. Proteins for SUGT1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex TAS10445024
    GO:0000776kinetochore TAS10445024
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    SUGT1 for ontologies           About GeneDecksing



    SUGT1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SUGT1
    GenScript Custom Superior Antibodies Services for SUGT1
    Novus Biologicals SUGT1 Antibodies
    Abcam antibodies for SUGT1
    Cloud-Clone Corp. Antibodies for SUGT1 
    ThermoFisher Antibodies for SUGT1
    LSBio Antibodies in human, mouse, rat for SUGT1 

    Assay Products for SUGT1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SUGT1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SUGT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SUGT1 
    Cloud-Clone Corp. CLIAs for SUGT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR011990 TPR-like_helical
     IPR007699 SGS
     IPR008978 HSP20-like_chaperone
     IPR017447 CS_domain
     IPR007052 CS-like_domain

    Graphical View of Domain Structure for InterPro Entry Q9Y2Z0

    ProtoNet protein and cluster: Q9Y2Z0

    1 Blocks protein domain: IPB007052 CS domain

    UniProtKB/Swiss-Prot: SUGT1_HUMAN, Q9Y2Z0
    Domain: The CS domain mediates interaction with HSP90
    Similarity: Belongs to the SUGT1 family
    Similarity: Contains 1 CS domain
    Similarity: Contains 1 SGS domain
    Similarity: Contains 3 TPR repeats


    SUGT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUGT1_HUMAN, Q9Y2Z0
    Function: May play a role in ubiquitination and subsequent proteasomal degradation of target proteins

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SUGT1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SUGT1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SUGT1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SUGT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUGT1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUGT1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUGT1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SUGT1:
    hsa-miR-376b hsa-miR-376a
    SwitchGear 3'UTR luciferase reporter plasmidSUGT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SUGT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUGT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SUGT1
    Sirion Biotech Customized adenovirus for overexpression of SUGT1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SUGT1 (see all 14)
    OriGene ORF clones in mouse, rat for SUGT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SUGT1 (NM_001130912)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUGT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUGT1
    Sirion Biotech Customized lentivirus for stable overexpression of SUGT1 
                         Customized lentivirus expression plasmids for stable overexpression of SUGT1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SUGT1
    Search LifeMap BioReagents cell lines for SUGT1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUGT1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SUGT1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.69
    NOD pathway0.33
    NOD-like receptor signaling pathway0.37
    2Inflammasomes
    The NLRP3 inflammasome0.71
    Inflammasomes0.71
    3Immune System
    Immune System0.56
    Innate Immune System0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SUGT1
        NOD pathway

    5        Reactome Pathways for SUGT1
        The NLRP3 inflammasome
    Inflammasomes
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Immune System
    Innate Immune System


    1         Kegg Pathway  (Kegg details for SUGT1):
        NOD-like receptor signaling pathway


    SUGT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SUGT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/829 Interacting proteins for SUGT1 (Q9Y2Z02, 3 ENSP000003672084) via UniProtKB, MINT, STRING, and/or I2D (see all 829)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48396 I2D: score=2 
    HSP90AA1P079002, 3, ENSP000003351534MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000335153
    HSP90B1P146252, 3, ENSP000002997674MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000299767
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    BUB3O436842, ENSP000003578584MINT-7945693 MINT-7947479 STRING: ENSP00000357858
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis TAS10445024
    GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS--
    GO:0045087innate immune response TAS--

    SUGT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUGT1

    Search CenterWatch for drugs/clinical trials and news about SUGT1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SUGT1 gene (2 alternative transcripts): 
    NM_001130912.1  NM_006704.3  

    Unigene Cluster for SUGT1:

    SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
    Hs.281902  [show with all ESTs]
    Unigene Representative Sequence: NM_001130912
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483074 ENST00000343788 ENST00000310528 ENST00000535397(uc001vhc.2 uc001vhb.2 uc010thb.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUGT1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SUGT1:
    hsa-miR-376b hsa-miR-376a
    SwitchGear 3'UTR luciferase reporter plasmidSUGT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SUGT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUGT1
    Clone
    Products:
         
    OriGene clones in human, mouse for SUGT1 (see all 14)
    OriGene ORF clones in mouse, rat for SUGT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SUGT1 (NM_001130912)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUGT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUGT1
    Sirion Biotech Customized lentivirus for stable overexpression of SUGT1 
                         Customized lentivirus expression plasmids for stable overexpression of SUGT1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SUGT1
    OriGene qSTAR qPCR primer pairs in human, mouse for SUGT1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SUGT1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUGT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUGT1

    Additional mRNA sequence: 

    AF132856.1 AJ344097.1 AK291402.1 AK292128.1 AK302363.1 AY271314.1 AY321358.1 BC000911.1 
    BT009798.1 

    13 DOTS entries:

    DT.100780457  DT.65284024  DT.97854428  DT.100731627  DT.95161781  DT.95161797  DT.97854424  DT.120761272 
    DT.120761284  DT.120761294  DT.40121249  DT.92451041  DT.97854425 

    24/212 AceView cDNA sequences (see all 212):

    BM549579 BU191274 AY321358 BM988188 AI471343 CD515556 BM839833 BU173965 
    BQ686395 AI915421 CK300334 BM788973 BE876387 AI282285 BM849524 BM727854 
    BU174100 BG575134 AF132856 CA748563 BX104850 BQ438248 BU838738 BI826084 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SUGT1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                    -                                                               
    SP2:                                                                                    
    SP3:                                                                                    


    ECgene alternative splicing isoforms for SUGT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUGT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAAATCCT
    SUGT1 Expression
    About this image


    See SUGT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUGT1

    SOURCE GeneReport for Unigene cluster: Hs.281902
        SABiosciences Expression via Pathway-Focused PCR Arrays including SUGT1: 
              Antiviral Response in human mouse rat
              Inflammasomes in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SUGT1
    OriGene qSTAR qPCR primer pairs in human, mouse for SUGT1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SUGT1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUGT1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUGT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUGT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUGT1 gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sugt11 , 5 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) less1, 5 86.59(n)1
    87.39(a)1
      14 (42.72 cM)5
    679551  NM_026474.51  NP_080750.11 
     795876915 
    chicken
    (Gallus gallus)
    Aves SUGT11 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) less 76.07(n)
    77.3(a)
      418827  NM_001030823.2  NP_001025994.2 
    lizard
    (Anolis carolinensis)
    Reptilia SUGT16
    SGT1, suppressor of G2 allele of SKP1 (S. cerevisi...
    69(a)
    1 ↔ 1
    3(70777842-70809909)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.252402 Xenopus laevis transcribed sequence with weak similarity to protein refNP_006695.1 (H.sapiens) suppressor of G2 allele of SKP1 [Homo sapiens] less 76.56(n)    CD302381.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd45a022 Transcribed sequence with moderate similarity to protein refNP_006695.1 (H.sapiens) suppressor of G2 allele of SKP1 [Homo sapiens] less 74.81(n)    57057639 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sgt11 CG9617-PA 54.34(n)
    49.71(a)
      40982  NM_141526.3  NP_649783.2 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_D1054.31 Protein D1054.3 51.61(n)
    40.86(a)
      179494  NM_073350.3  NP_505751.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SGT11 Sgt1p 53.65(n)
    41.18(a)
      854222   NP_014700.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SGT1B1 phosphatase SGT1b 50.5(n)
    40.12(a)
      826728  NM_117197.3  NP_192865.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g06245001 hypothetical protein 50.75(n)
    40.17(a)
      4326682  NM_001050155.1  NP_001043620.1 


    ENSEMBL Gene Tree for SUGT1 (if available)
    TreeFam Gene Tree for SUGT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUGT1 gene
    1 SIMAP similar gene for SUGT1 using alignment to 2 protein entries:     SUGT1_HUMAN (see all proteins):
    OK/SW-cl.41

    SUGT1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SUGT1
    PGOHUM00000238672 PGOHUM00000237985


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/744 SNPs in SUGT1 are shown (see all 744)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1403822121,2
    C--33959655(+) TTAAA-/AAGAGAAT 2 -- cds10--------
    rs2009872431,2
    --33962395(+) TTTTT-/TCTTTTT 2 -- int10--------
    rs2016542141,2
    --33962396(+) TTTTT-/CTTTTT 2 -- int10--------
    rs355370471,2
    C--33970163(+) AAAAAA/-GAGAG 2 -- int11Minor allele frequency- -:0.00NA 2
    rs781050291,2
    C--33970177(+) AAAAAG/AAGAGA 2 -- int11Minor allele frequency- A:0.50NA 2
    rs357630081,2
    C--33970719(+) TGGGG-/GTGTCT 2 -- int12Minor allele frequency- G:0.00NA CSA 4
    rs800113021,2
    C--33972749(+) TTTTT-/GGTTCT 2 -- int10--------
    rs359287011,2
    C--33975704(+) AATCA-/TTTTTT 2 -- int10--------
    rs1169159491,2
    F--34162467(+) TAACCG/AGAGCA 2 -- us2k11Minor allele frequency- A:0.02EA 120
    rs14367291,2
    C,F,A,H--34162541(-) tggctA/Gctcct 2 -- us2k114Minor allele frequency- G:0.03MN NA WA CSA EA 560

    HapMap Linkage Disequilibrium report for SUGT1 (53226831 - 53262433 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SUGT1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv900088CNV Loss21882294
    nsv819201CNV Gain19587683
    nsv820041CNV Gain19587683

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SUGT1
    DNA2.0 Custom Variant and Variant Library Synthesis for SUGT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604098    OMIM disorders: --

    3 diseases for SUGT1:    About MalaCards
    polydactyly    colorectal cancer    lung cancer


    SUGT1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SUGT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    plant diseases 77.2 3 11847308 (1), 14761955 (1), 12456004 (1)


    Export disorders for SUGT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUGT1 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with SUGT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. (PubMed id 10445024)1, 2, 3 Kitagawa K.... Hieter P. (1999)
    2. Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain. (PubMed id 14761955)1, 2, 9 Lee Y.-T....Chazin W.J. (2004)
    3. Identification of a novel splice variant: human SGT1B (SUGT1B). (PubMed id 15018354)1, 2, 9 Niikura Y. and Kitagawa K. (2003)
    4. Nuclear translocation of Sgt1 depends on its phosphorylation state. (PubMed id 21864708)1, 2 Prus W.... Filipek A. (2011)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    8. Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. (PubMed id 12746458)1, 2 Nowotny M....Kuznicki J. (2003)
    9. Overexpression of SUGT1 in human colorectal cancer an d its clinicopathological significance. (PubMed id 20126976)1, 9 Iwatsuki M....Mori M. (2010)
    10. 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation. (PubMed id 16501598)1, 9 Niikura Y....Kitagawa K. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10910 HGNC: 16987 AceView: SUGT1 Ensembl:ENSG00000165416 euGenes: HUgn10910
    ECgene: SUGT1 Kegg: 10910 H-InvDB: SUGT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUGT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SUGT1 gene:
    Search GeneIP for patents involving SUGT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SUGT1  
     OriGene qPCR primer pairs and template standards for SUGT1   OriGene Protein Over-expression Lysate for SUGT1  
     OriGene MassSpec something-or-other for SUGT1   OriGene clones in human, mouse for SUGT1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SUGT1   OriGene Purified Protein for SUGT1  
     OriGene ORF clones in mouse, rat for SUGT1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SUGT1   OriGene Custom Protein Services for SUGT1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SUGT1
     QIAGEN SeqTarget long-range PCR primers for resequencing SUGT1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUGT1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUGT1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUGT1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUGT1
     GenScript Custom Purified and Recombinant Proteins Services for SUGT1 GenScript cDNA clones with any tag delivered in your preferred vector for SUGT1
     GenScript Custom Assay Services for SUGT1 GenScript Custom Superior Antibodies Services for SUGT1
     GenScript Custom overexpressing Cell Line Services for SUGT1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SUGT1 promoter
     Search Chromatin IP Primers for SUGT1
     RT2 qPCR Primer Assay in human, mouse, rat SUGT1
     GNC Network for SUGT1
     SABiosciences PCR Arrays including human, mouse, rat SUGT1
     Search Tocris compounds for SUGT1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SUGT1 antibodies
     SUGT1 proteins
     SUGT1 lysates
     Antibodies for SUGT1
     See all of Abcam's Antibodies, Kits and Proteins for SUGT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SUGT1




     Proteins for SUGT1
     Antibodies for SUGT1
     ELISAs for SUGT1
     CLIAs for SUGT1
     Search LifeMap BioReagents cell lines for SUGT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUGT1
     SwitchGear 3'UTR luciferase reporter plasmids for SUGT1
     SwitchGear Promoter luciferase reporter plasmids for SUGT1
     ThermoFisher Antibodies for SUGT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUGT1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SUGT1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SUGT1
    Customized:
     lentivirus for stable overexpression of SUGT1
     lentivirus expression plasmids for stable overexpression of SUGT1
     adenovirus for overexpression of SUGT1
     LSBio Antibodies in human, mouse, rat for SUGT1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SUGT1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4