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Aliases for SUGT1 Gene

Aliases for SUGT1 Gene

  • SGT1 Homolog, MIS12 Kinetochore Complex Assembly Cochaperone 2 3 5
  • SGT1 3 4
  • Suppressor Of G2 Allele Of SKP1, S. Cerevisiae, Homolog Of 3
  • SGT1, Suppressor Of G2 Allele Of SKP1 (S. Cerevisiae) 2
  • Suppressor Of G2 Allele Of SKP1 Homolog 4
  • SGT1, Suppressor Of G2 Allele Of SKP1 3
  • Putative 40-6-3 Protein 3
  • Protein 40-6-3 4

External Ids for SUGT1 Gene

Previous GeneCards Identifiers for SUGT1 Gene

  • GC13P047221
  • GC13P052163
  • GC13P051024
  • GC13P051025
  • GC13P052124
  • GC13P053226
  • GC13P033941

Summaries for SUGT1 Gene

Entrez Gene Summary for SUGT1 Gene

  • This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]

GeneCards Summary for SUGT1 Gene

SUGT1 (SGT1 Homolog, MIS12 Kinetochore Complex Assembly Cochaperone) is a Protein Coding gene. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Immune System.

UniProtKB/Swiss-Prot for SUGT1 Gene

  • May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for SUGT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUGT1 Gene

Genomics for SUGT1 Gene

Regulatory Elements for SUGT1 Gene

Enhancers for SUGT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SUGT1 on UCSC Golden Path with GeneCards custom track

Promoters for SUGT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUGT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUGT1 Gene

Chromosome:
13
Start:
52,652,696 bp from pter
End:
52,700,909 bp from pter
Size:
48,214 bases
Orientation:
Plus strand

Genomic View for SUGT1 Gene

Genes around SUGT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUGT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUGT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUGT1 Gene

Proteins for SUGT1 Gene

  • Protein details for SUGT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Z0-SGT1_HUMAN
    Recommended name:
    Protein SGT1 homolog
    Protein Accession:
    Q9Y2Z0
    Secondary Accessions:
    • A2A303
    • Q5JAK5
    • Q5TAM6
    • Q6VXY6

    Protein attributes for SUGT1 Gene

    Size:
    365 amino acids
    Molecular mass:
    41024 Da
    Quaternary structure:
    • Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts with S100A6. Interacts with HSP90.

    Three dimensional structures from OCA and Proteopedia for SUGT1 Gene

    Alternative splice isoforms for SUGT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUGT1 Gene

Proteomics data for SUGT1 Gene at MOPED

Post-translational modifications for SUGT1 Gene

  • Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.
  • Ubiquitination at Lys 256, Lys 267, Lys 274, and Lys 349
  • Modification sites at PhosphoSitePlus

Other Protein References for SUGT1 Gene

No data available for DME Specific Peptides for SUGT1 Gene

Domains & Families for SUGT1 Gene

Protein Domains for SUGT1 Gene

Suggested Antigen Peptide Sequences for SUGT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2Z0

UniProtKB/Swiss-Prot:

SGT1_HUMAN :
  • The CS domain mediates interaction with HSP90.
  • Belongs to the SGT1 family.
  • Contains 3 TPR repeats.
Domain:
  • The CS domain mediates interaction with HSP90.
  • Contains 1 CS domain.
  • Contains 1 SGS domain.
Family:
  • Belongs to the SGT1 family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with SUGT1: view

No data available for Gene Families for SUGT1 Gene

Function for SUGT1 Gene

Molecular function for SUGT1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
genes like me logo Genes that share phenotypes with SUGT1: view

Animal Model Products

miRNA for SUGT1 Gene

miRTarBase miRNAs that target SUGT1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUGT1 Gene

Localization for SUGT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUGT1 Gene

Cytoplasm. Nucleus. Note=Translocates to the nucleus upon heat shock, requiring S100A6.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUGT1 Gene COMPARTMENTS Subcellular localization image for SUGT1 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SUGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore TAS 10445024
GO:0043234 protein complex IDA 23184943
genes like me logo Genes that share ontologies with SUGT1: view

Pathways & Interactions for SUGT1 Gene

genes like me logo Genes that share pathways with SUGT1: view

Pathways by source for SUGT1 Gene

Gene Ontology (GO) - Biological Process for SUGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031647 regulation of protein stability IDA 23935490
genes like me logo Genes that share ontologies with SUGT1: view

No data available for SIGNOR curated interactions for SUGT1 Gene

Drugs & Compounds for SUGT1 Gene

No Compound Related Data Available

Transcripts for SUGT1 Gene

Unigene Clusters for SUGT1 Gene

SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUGT1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2:
SP3:

Relevant External Links for SUGT1 Gene

GeneLoc Exon Structure for
SUGT1
ECgene alternative splicing isoforms for
SUGT1

Expression for SUGT1 Gene

mRNA expression in normal human tissues for SUGT1 Gene

Protein differential expression in normal tissues from HIPED for SUGT1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUGT1 Gene



SOURCE GeneReport for Unigene cluster for SUGT1 Gene Hs.281902

genes like me logo Genes that share expression patterns with SUGT1: view

Protein tissue co-expression partners for SUGT1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SUGT1 Gene

Orthologs for SUGT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUGT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUGT1 35
  • 93.56 (n)
  • 91.28 (a)
SUGT1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUGT1 35
  • 94.29 (n)
  • 92.21 (a)
-- 36
  • 95 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sugt1 35
  • 86.58 (n)
  • 87.62 (a)
Sugt1 16
Sugt1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUGT1 35
  • 99.82 (n)
  • 100 (a)
SUGT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sugt1 35
  • 87.82 (n)
  • 88.24 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SUGT1 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUGT1 35
  • 76.16 (n)
  • 77.85 (a)
SUGT1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUGT1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9278 35
sugt1 35
  • 67.51 (n)
  • 66.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25240 35
zebrafish
(Danio rerio)
Actinopterygii sgut1 35
  • 64.92 (n)
  • 64.38 (a)
wufd45a02 35
sgut1 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3362 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006161 35
  • 52.04 (n)
  • 42.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sgt1 35
  • 53.45 (n)
  • 47.7 (a)
Sgt1 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_D1054.3 35
  • 52.15 (n)
  • 40.32 (a)
D1054.3 36
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT1 36
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons SGT1B 35
  • 50.5 (n)
  • 40.12 (a)
rice
(Oryza sativa)
Liliopsida Os01g0624500 35
  • 51.79 (n)
  • 41.96 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8167 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3670 36
  • 47 (a)
OneToOne
Species with no ortholog for SUGT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUGT1 Gene

ENSEMBL:
Gene Tree for SUGT1 (if available)
TreeFam:
Gene Tree for SUGT1 (if available)

Paralogs for SUGT1 Gene

(1) SIMAP similar genes for SUGT1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SUGT1 Gene

genes like me logo Genes that share paralogs with SUGT1: view

No data available for Paralogs for SUGT1 Gene

Variants for SUGT1 Gene

Sequence variations from dbSNP and Humsavar for SUGT1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs964946 -- 52,661,765(+) CAATA(G/T)TTCTC intron-variant
rs971513 -- 52,679,151(+) ATAGT(C/G)AACAG intron-variant
rs973198 -- 52,676,704(+) TTTCT(A/G)TTCCT intron-variant
rs1299937 -- 52,651,875(-) gtatt(C/T)ctagg upstream-variant-2KB
rs1057478 -- 52,651,983(-) AACTT(C/T)ATACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SUGT1 Gene

Variant ID Type Subtype PubMed ID
nsv820041 CNV Gain 19587683
nsv819201 CNV Gain 19587683
nsv900088 CNV Loss 21882294

Variation tolerance for SUGT1 Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUGT1 Gene

HapMap Linkage Disequilibrium report
SUGT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUGT1 Gene

Disorders for SUGT1 Gene

Relevant External Links for SUGT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUGT1

No disorders were found for SUGT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUGT1 Gene

Publications for SUGT1 Gene

  1. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. (PMID: 10445024) Kitagawa K. … Hieter P. (Mol. Cell 1999) 2 3 4 67
  2. Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites. (PMID: 20404110) Davies A.E. … Kaplan K.B. (J. Cell Biol. 2010) 2 3 23
  3. Overexpression of SUGT1 in human colorectal cancer and its clinicopathological significance. (PMID: 20126976) Iwatsuki M. … Mori M. (Int. J. Oncol. 2010) 3 23
  4. 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation. (PMID: 16501598) Niikura Y. … Kitagawa K. (Oncogene 2006) 3 23
  5. Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain. (PMID: 14761955) Lee Y.-T. … Chazin W.J. (J. Biol. Chem. 2004) 3 23

Products for SUGT1 Gene

Sources for SUGT1 Gene

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