Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SUGT1 Gene

Aliases for SUGT1 Gene

  • SGT1 Homolog, MIS12 Kinetochore Complex Assembly Cochaperone 2 3 5
  • SGT1 3 4
  • Suppressor Of G2 Allele Of SKP1, S. Cerevisiae, Homolog Of 3
  • SGT1, Suppressor Of G2 Allele Of SKP1 (S. Cerevisiae) 2
  • Suppressor Of G2 Allele Of SKP1 Homolog 4
  • SGT1, Suppressor Of G2 Allele Of SKP1 3
  • Putative 40-6-3 Protein 3
  • Protein SGT1 Homolog 3
  • Protein 40-6-3 4

External Ids for SUGT1 Gene

Previous GeneCards Identifiers for SUGT1 Gene

  • GC13P047221
  • GC13P052163
  • GC13P051024
  • GC13P051025
  • GC13P052124
  • GC13P053226
  • GC13P033941

Summaries for SUGT1 Gene

Entrez Gene Summary for SUGT1 Gene

  • This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]

GeneCards Summary for SUGT1 Gene

SUGT1 (SGT1 Homolog, MIS12 Kinetochore Complex Assembly Cochaperone) is a Protein Coding gene. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Innate Immune System.

UniProtKB/Swiss-Prot for SUGT1 Gene

  • May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for SUGT1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUGT1 Gene

Genomics for SUGT1 Gene

Regulatory Elements for SUGT1 Gene

Enhancers for SUGT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G052301 0.2 ENCODE 4 -350.6 -350647 1.3 CKAP2 SUGT1 ENSG00000217576 TPTE2P2
GH13G052650 1.1 ENCODE 0.7 -0.1 -71 3.7 MLX CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CKAP2 TPTE2P2 SUGT1 ENSG00000273723
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SUGT1 on UCSC Golden Path with GeneCards custom track

Promoters for SUGT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000063151 4 3001 FOXA2 MLX CREB3L1 ARNT AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1

Genomic Location for SUGT1 Gene

Chromosome:
13
Start:
52,652,696 bp from pter
End:
52,700,909 bp from pter
Size:
48,214 bases
Orientation:
Plus strand

Genomic View for SUGT1 Gene

Genes around SUGT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUGT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUGT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUGT1 Gene

Proteins for SUGT1 Gene

  • Protein details for SUGT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Z0-SGT1_HUMAN
    Recommended name:
    Protein SGT1 homolog
    Protein Accession:
    Q9Y2Z0
    Secondary Accessions:
    • A2A303
    • Q5JAK5
    • Q5TAM6
    • Q6VXY6

    Protein attributes for SUGT1 Gene

    Size:
    365 amino acids
    Molecular mass:
    41024 Da
    Quaternary structure:
    • Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts with S100A6. Interacts with HSP90.

    Three dimensional structures from OCA and Proteopedia for SUGT1 Gene

    Alternative splice isoforms for SUGT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUGT1 Gene

Post-translational modifications for SUGT1 Gene

  • Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.
  • Ubiquitination at Lys256, posLast=267267, Lys274, and Lys349
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SUGT1 Gene

Domains & Families for SUGT1 Gene

Suggested Antigen Peptide Sequences for SUGT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2Z0

UniProtKB/Swiss-Prot:

SGT1_HUMAN :
  • The CS domain mediates interaction with HSP90.
  • Belongs to the SGT1 family.
Domain:
  • The CS domain mediates interaction with HSP90.
Family:
  • Belongs to the SGT1 family.
genes like me logo Genes that share domains with SUGT1: view

No data available for Gene Families for SUGT1 Gene

Function for SUGT1 Gene

Molecular function for SUGT1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for SUGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21566117
genes like me logo Genes that share ontologies with SUGT1: view
genes like me logo Genes that share phenotypes with SUGT1: view

Animal Models for SUGT1 Gene

MGI Knock Outs for SUGT1:

Animal Model Products

miRNA for SUGT1 Gene

miRTarBase miRNAs that target SUGT1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUGT1 Gene

Localization for SUGT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUGT1 Gene

Cytoplasm. Nucleus. Note=Translocates to the nucleus upon heat shock, requiring S100A6.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUGT1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SUGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex TAS 10445024
GO:0000776 kinetochore TAS 10445024
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SUGT1: view

Pathways & Interactions for SUGT1 Gene

genes like me logo Genes that share pathways with SUGT1: view

Gene Ontology (GO) - Biological Process for SUGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS 10445024
GO:0007067 mitotic nuclear division TAS --
GO:0031647 regulation of protein stability IDA 23935490
GO:0043947 positive regulation by host of symbiont catalytic activity IDA 23935490
genes like me logo Genes that share ontologies with SUGT1: view

No data available for SIGNOR curated interactions for SUGT1 Gene

Transcripts for SUGT1 Gene

Unigene Clusters for SUGT1 Gene

SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUGT1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2:
SP3:

Relevant External Links for SUGT1 Gene

GeneLoc Exon Structure for
SUGT1
ECgene alternative splicing isoforms for
SUGT1

Expression for SUGT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUGT1 Gene

Protein differential expression in normal tissues from HIPED for SUGT1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUGT1 Gene



Protein tissue co-expression partners for SUGT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SUGT1 Gene:

SUGT1

SOURCE GeneReport for Unigene cluster for SUGT1 Gene:

Hs.281902

Evidence on tissue expression from TISSUES for SUGT1 Gene

  • Nervous system(4.5)
  • Blood(4.2)
  • Liver(4.2)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with SUGT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUGT1 Gene

Orthologs for SUGT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUGT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUGT1 34 35
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 95 (a)
OneToMany
SUGT1 34
  • 94.29 (n)
-- 35
  • 94 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SUGT1 34 35
  • 93.56 (n)
rat
(Rattus norvegicus)
Mammalia Sugt1 34
  • 87.82 (n)
mouse
(Mus musculus)
Mammalia Sugt1 34 16 35
  • 86.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SUGT1 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUGT1 34 35
  • 76.16 (n)
lizard
(Anolis carolinensis)
Reptilia SUGT1 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sugt1 34
  • 67.51 (n)
Str.9278 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25240 34
zebrafish
(Danio rerio)
Actinopterygii sgut1 34 35
  • 64.92 (n)
wufd45a02 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3362 34
fruit fly
(Drosophila melanogaster)
Insecta Sgt1 34 35
  • 53.45 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006161 34
  • 52.04 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_D1054.3 34
  • 52.15 (n)
D1054.3 35
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT1 35
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons SGT1B 34
  • 50.5 (n)
rice
(Oryza sativa)
Liliopsida Os01g0624500 34
  • 51.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3670 35
  • 47 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8167 34
Species where no ortholog for SUGT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUGT1 Gene

ENSEMBL:
Gene Tree for SUGT1 (if available)
TreeFam:
Gene Tree for SUGT1 (if available)

Paralogs for SUGT1 Gene

(1) SIMAP similar genes for SUGT1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SUGT1: view

No data available for Paralogs for SUGT1 Gene

Variants for SUGT1 Gene

Sequence variations from dbSNP and Humsavar for SUGT1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000028735 -- 52,695,465(+) CACTG(G/T)ATGAT utr-variant-3-prime
rs1000034985 -- 52,686,423(+) ATTGC(A/G)ACAAT intron-variant
rs1000061766 -- 52,664,326(+) AGAGT(C/G)TCTTC intron-variant
rs1000083025 -- 52,652,315(+) CTTCC(A/G)GCAAG upstream-variant-2KB
rs1000090171 -- 52,660,846(+) CTGTC(A/G)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUGT1 Gene

Variant ID Type Subtype PubMed ID
dgv1653n100 CNV gain 25217958
nsv1044949 CNV gain 25217958
nsv819201 CNV gain 19587683
nsv820041 CNV gain 19587683
nsv974091 CNV duplication 23825009
nsv974092 CNV duplication 23825009

Variation tolerance for SUGT1 Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUGT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUGT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUGT1 Gene

Disorders for SUGT1 Gene

Relevant External Links for SUGT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUGT1

No disorders were found for SUGT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUGT1 Gene

Publications for SUGT1 Gene

  1. Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites. (PMID: 20404110) Davies A.E. … Kaplan K.B. (J. Cell Biol. 2010) 2 3 22 64
  2. Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain. (PMID: 14761955) Lee Y.-T. … Chazin W.J. (J. Biol. Chem. 2004) 3 4 22 64
  3. Identification of a novel splice variant: human SGT1B (SUGT1B). (PMID: 15018354) Niikura Y. … Kitagawa K. (DNA Seq. 2003) 3 4 22 64
  4. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. (PMID: 10445024) Kitagawa K. … Hieter P. (Mol. Cell 1999) 2 3 4 64
  5. Nuclear translocation of Sgt1 depends on its phosphorylation state. (PMID: 21864708) Prus W. … Filipek A. (Int. J. Biochem. Cell Biol. 2011) 3 4 64

Products for SUGT1 Gene

Sources for SUGT1 Gene

Content
Loading form....