Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SUGT1 Gene

Aliases for SUGT1 Gene

  • SGT1, Suppressor Of G2 Allele Of SKP1 (S. Cerevisiae) 2 3
  • SGT1 3 4 6
  • Suppressor Of G2 Allele Of SKP1, S. Cerevisiae, Homolog Of 3
  • Suppressor Of G2 Allele Of SKP1 Homolog 3
  • Putative 40-6-3 Protein 3
  • Protein 40-6-3 4
  • SGT1B Protein 3

External Ids for SUGT1 Gene

Previous GeneCards Identifiers for SUGT1 Gene

  • GC13P047221
  • GC13P052163
  • GC13P051024
  • GC13P051025
  • GC13P052124
  • GC13P053226
  • GC13P033941

Summaries for SUGT1 Gene

Entrez Gene Summary for SUGT1 Gene

  • This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for SUGT1 Gene

SUGT1 (SGT1, Suppressor Of G2 Allele Of SKP1 (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways.

UniProtKB/Swiss-Prot for SUGT1 Gene

  • May play a role in ubiquitination and subsequent proteasomal degradation of target proteins

Gene Wiki entry for SUGT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUGT1 Gene

Genomics for SUGT1 Gene

Regulatory Elements for SUGT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SUGT1 Gene

Start:
52,652,696 bp from pter
End:
52,700,909 bp from pter
Size:
48,214 bases
Orientation:
Plus strand

Genomic View for SUGT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUGT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUGT1 Gene

Proteins for SUGT1 Gene

  • Protein details for SUGT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Z0-SUGT1_HUMAN
    Recommended name:
    Suppressor of G2 allele of SKP1 homolog
    Protein Accession:
    Q9Y2Z0
    Secondary Accessions:
    • A2A303
    • Q5JAK5
    • Q5TAM6
    • Q6VXY6

    Protein attributes for SUGT1 Gene

    Size:
    365 amino acids
    Molecular mass:
    41024 Da
    Quaternary structure:
    • Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts with S100A6. Interacts with HSP90.

    Three dimensional structures from OCA and Proteopedia for SUGT1 Gene

    Alternative splice isoforms for SUGT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUGT1 Gene

Proteomics data for SUGT1 Gene at MOPED

Post-translational modifications for SUGT1 Gene

  • Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.
  • Ubiquitination at Lys256, Lys267, Lys274, Lys325, and Lys349
  • Modification sites at PhosphoSitePlus

Other Protein References for SUGT1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SUGT1 Gene

Domains for SUGT1 Gene

Protein Domains for SUGT1 Gene

Suggested Antigen Peptide Sequences for SUGT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2Z0

UniProtKB/Swiss-Prot:

SUGT1_HUMAN :
  • Q9Y2Z0
Domain:
  • The CS domain mediates interaction with HSP90
  • Contains 1 CS domain.
  • Contains 1 SGS domain.
Family:
  • Belongs to the SUGT1 family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with SUGT1: view

No data available for Gene Families for SUGT1 Gene

Function for SUGT1 Gene

Molecular function for SUGT1 Gene

UniProtKB/Swiss-Prot Function: May play a role in ubiquitination and subsequent proteasomal degradation of target proteins

Gene Ontology (GO) - Molecular Function for SUGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24255178
genes like me logo Genes that share ontologies with SUGT1: view

Phenotypes for SUGT1 Gene

GenomeRNAi human phenotypes for SUGT1:
genes like me logo Genes that share phenotypes with SUGT1: view

Animal Model Products

CRISPR Products

miRNA for SUGT1 Gene

miRTarBase miRNAs that target SUGT1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUGT1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SUGT1 Gene

Localization for SUGT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUGT1 Gene

Cytoplasm. Nucleus. Note=Translocates to the nucleus upon heat shock, requiring S100A6.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUGT1 Gene COMPARTMENTS Subcellular localization image for SUGT1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SUGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex TAS 10445024
GO:0000776 kinetochore TAS 10445024
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SUGT1: view

Pathways for SUGT1 Gene

genes like me logo Genes that share pathways with SUGT1: view

Pathways by source for SUGT1 Gene

1 KEGG pathway for SUGT1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for SUGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division TAS 10445024
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with SUGT1: view

Transcripts for SUGT1 Gene

Unigene Clusters for SUGT1 Gene

SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUGT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUGT1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2:
SP3:

Relevant External Links for SUGT1 Gene

GeneLoc Exon Structure for
SUGT1
ECgene alternative splicing isoforms for
SUGT1

Expression for SUGT1 Gene

mRNA expression in normal human tissues for SUGT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUGT1 Gene

SOURCE GeneReport for Unigene cluster for SUGT1 Gene Hs.281902

genes like me logo Genes that share expressions with SUGT1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SUGT1 Gene

Orthologs for SUGT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUGT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUGT1 35
  • 99.82 (n)
  • 100 (a)
SUGT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUGT1 35
  • 93.56 (n)
  • 91.28 (a)
SUGT1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
SUGT1 35
  • 94.29 (n)
  • 92.21 (a)
mouse
(Mus musculus)
Mammalia Sugt1 35
  • 86.58 (n)
  • 87.62 (a)
Sugt1 16
Sugt1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUGT1 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sugt1 35
  • 87.82 (n)
  • 88.24 (a)
chicken
(Gallus gallus)
Aves SUGT1 35
  • 76.16 (n)
  • 77.85 (a)
SUGT1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUGT1 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25240 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9278 35
sugt1 35
  • 67.51 (n)
  • 66.77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3362 35
zebrafish
(Danio rerio)
Actinopterygii sgut1 35
  • 64.92 (n)
  • 64.38 (a)
sgut1 36
  • 61 (a)
OneToOne
wufd45a02 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006161 35
  • 52.04 (n)
  • 42.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sgt1 35
  • 53.45 (n)
  • 47.7 (a)
Sgt1 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_D1054.3 35
  • 52.15 (n)
  • 40.32 (a)
D1054.3 36
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT1 36
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons SGT1B 35
  • 50.5 (n)
  • 40.12 (a)
rice
(Oryza sativa)
Liliopsida Os01g0624500 35
  • 51.79 (n)
  • 41.96 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8167 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3670 36
  • 47 (a)
OneToOne
Species with no ortholog for SUGT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUGT1 Gene

ENSEMBL:
Gene Tree for SUGT1 (if available)
TreeFam:
Gene Tree for SUGT1 (if available)

Paralogs for SUGT1 Gene

Selected SIMAP similar genes for SUGT1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SUGT1 Gene

genes like me logo Genes that share paralogs with SUGT1: view

No data available for Paralogs for SUGT1 Gene

Variants for SUGT1 Gene

Sequence variations from dbSNP and Humsavar for SUGT1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs964946 -- 52,661,765(+) CAATA(G/T)TTCTC intron-variant
rs971513 -- 52,679,151(+) ATAGT(C/G)AACAG intron-variant
rs973198 -- 52,676,704(+) TTTCT(A/G)TTCCT intron-variant
rs1057478 -- 52,651,983(-) AACTT(C/T)ATACC upstream-variant-2KB
rs1299937 -- 52,651,875(-) gtatt(C/T)ctagg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SUGT1 Gene

Variant ID Type Subtype PubMed ID
nsv820041 CNV Gain 19587683
nsv819201 CNV Gain 19587683
nsv900088 CNV Loss 21882294

Relevant External Links for SUGT1 Gene

HapMap Linkage Disequilibrium report
SUGT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUGT1 Gene

Disorders for SUGT1 Gene

(1) Novoseek inferred disease relationships for SUGT1 Gene

Disease -log(P) Hits PubMed IDs
plant diseases 77.2 3
genes like me logo Genes that share disorders with SUGT1: view

No data available for UniProtKB/Swiss-Prot for SUGT1 Gene

Publications for SUGT1 Gene

  1. Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain. (PMID: 14761955) Lee Y.-T. … Chazin W.J. (J. Biol. Chem. 2004) 3 4 23
  2. Identification of a novel splice variant: human SGT1B (SUGT1B). (PMID: 15018354) Niikura Y. … Kitagawa K. (DNA Seq. 2003) 3 4 23
  3. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. (PMID: 10445024) Kitagawa K. … Hieter P. (Mol. Cell 1999) 2 3 4
  4. Overexpression of SUGT1 in human colorectal cancer and its clinicopathological significance. (PMID: 20126976) Iwatsuki M. … Mori M. (Int. J. Oncol. 2010) 3 23
  5. Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites. (PMID: 20404110) Davies A.E. … Kaplan K.B. (J. Cell Biol. 2010) 3 23

Products for SUGT1 Gene

Sources for SUGT1 Gene

Back to Top

Content