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Aliases for SUGP2 Gene

Aliases for SUGP2 Gene

  • SURP And G Patch Domain Containing 2 2 3
  • Splicing Factor, Arginine/Serine-Rich 14 2 3 4
  • Arginine/Serine-Rich-Splicing Factor 14 3 4
  • KIAA0365 4 6
  • SFRS14 3 4
  • Putative Splicing Factor, Arginine/Serine-Rich 14 3
  • SURP And G-Patch Domain-Containing Protein 2 3
  • Arginine/Serine-Rich 14 Splicing Factor 3
  • SRFS14 6

External Ids for SUGP2 Gene

Previous Symbols for SUGP2 Gene

  • SFRS14

Summaries for SUGP2 Gene

Entrez Gene Summary for SUGP2 Gene

  • This gene encodes a member of the arginine/serine-rich family of splicing factors. The encoded protein functions in mRNA processing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GeneCards Summary for SUGP2 Gene

SUGP2 (SURP And G Patch Domain Containing 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding. An important paralog of this gene is SUGP1.

UniProtKB/Swiss-Prot for SUGP2 Gene

  • May play a role in mRNA splicing.

Gene Wiki entry for SUGP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUGP2 Gene

Genomics for SUGP2 Gene

Genomic Location for SUGP2 Gene

Start:
18,990,888 bp from pter
End:
19,034,038 bp from pter
Size:
43,151 bases
Orientation:
Minus strand

Genomic View for SUGP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUGP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUGP2 Gene

No data available for Regulatory Elements for SUGP2 Gene

Proteins for SUGP2 Gene

  • Protein details for SUGP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX01-SUGP2_HUMAN
    Recommended name:
    SURP and G-patch domain-containing protein 2
    Protein Accession:
    Q8IX01
    Secondary Accessions:
    • C9JI71
    • O15071
    • O60369
    • Q5JPH7
    • Q8WUF7

    Protein attributes for SUGP2 Gene

    Size:
    1082 amino acids
    Molecular mass:
    120207 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC06129.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH20586.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA20820.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SUGP2 Gene

    Alternative splice isoforms for SUGP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUGP2 Gene

Proteomics data for SUGP2 Gene at MOPED

Post-translational modifications for SUGP2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys137, Lys228, Lys305, Lys595, Lys650, and Lys673

No data available for DME Specific Peptides for SUGP2 Gene

Domains for SUGP2 Gene

Gene Families for SUGP2 Gene

HGNC:
  • GPATCH :G patch domain containing

Protein Domains for SUGP2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SUGP2_HUMAN
Domain:
  • Contains 1 G-patch domain.:
    • Q8IX01
Similarity:
  • Contains 2 SURP motif repeats.:
    • Q8IX01
genes like me logo Genes that share domains with SUGP2: view

Function for SUGP2 Gene

Molecular function for SUGP2 Gene

UniProtKB/Swiss-Prot Function: May play a role in mRNA splicing.

Gene Ontology (GO) - Molecular Function for SUGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SUGP2: view

Phenotypes for SUGP2 Gene

GenomeRNAi human phenotypes for SUGP2:
genes like me logo Genes that share phenotypes with SUGP2: view

miRNA for SUGP2 Gene

miRTarBase miRNAs that target SUGP2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SUGP2 Gene

Localization for SUGP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUGP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUGP2 Gene COMPARTMENTS Subcellular localization image for SUGP2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for SUGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SUGP2: view

Pathways for SUGP2 Gene

SuperPathways for SUGP2 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with SUGP2: view

Pathways by source for SUGP2 Gene

1 BioSystems pathway for SUGP2 Gene

Gene Ontology (GO) - Biological Process for SUGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SUGP2: view

Transcripts for SUGP2 Gene

Unigene Clusters for SUGP2 Gene

SURP and G patch domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUGP2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^
SP1:
SP2: - -
SP3: - -
SP4:
SP5: - - -
SP6: -
SP7:
SP8:
SP9: -
SP10:
SP11:

ExUns: 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SUGP2 Gene

GeneLoc Exon Structure for
SUGP2
ECgene alternative splicing isoforms for
SUGP2

Expression for SUGP2 Gene

mRNA expression in normal human tissues for SUGP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUGP2 Gene

SOURCE GeneReport for Unigene cluster for SUGP2 Gene Hs.515271

mRNA Expression by UniProt/SwissProt for SUGP2 Gene

Q8IX01-SUGP2_HUMAN
Tissue specificity: Detected in adult testis, and in fetal brain and kidney.
genes like me logo Genes that share expressions with SUGP2: view

Orthologs for SUGP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUGP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUGP2 36
  • 96.42 (n)
  • 95.65 (a)
SUGP2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUGP2 36
  • 86.83 (n)
  • 85.81 (a)
SUGP2 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUGP2 36
  • 87.52 (n)
  • 87.77 (a)
SUGP2 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sugp2 36
  • 77.45 (n)
  • 75.97 (a)
Sugp2 16
Sugp2 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUGP2 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUGP2 37
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sugp2 36
  • 76.76 (n)
  • 75.5 (a)
chicken
(Gallus gallus)
Aves SUGP2 36
  • 63.01 (n)
  • 59.18 (a)
SUGP2 37
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUGP2 37
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29339 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19689 36
fruit fly
(Drosophila melanogaster)
Insecta CG31550 37
  • 12 (a)
OneToMany
Species with no ortholog for SUGP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SUGP2 Gene

ENSEMBL:
Gene Tree for SUGP2 (if available)
TreeFam:
Gene Tree for SUGP2 (if available)

Paralogs for SUGP2 Gene

Paralogs for SUGP2 Gene

Selected SIMAP similar genes for SUGP2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SUGP2: view

Variants for SUGP2 Gene

Sequence variations from dbSNP and Humsavar for SUGP2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs12016 -- 18,991,781(-) TCATC(A/T)TCTCC intron-variant, nc-transcript-variant
rs1079543 -- 19,007,124(+) CACCC(C/T)GGGGA intron-variant
rs1124921 -- 19,006,593(-) TTTCA(C/T)TTTCT intron-variant
rs1137624 -- 18,992,188(-) ttgta(A/G)tccca downstream-variant-500B, intron-variant, nc-transcript-variant
rs1859267 -- 19,013,241(+) TTCAC(A/T)ATCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUGP2 Gene

Variant ID Type Subtype PubMed ID
nsv833778 CNV Loss 17160897
nsv2435 CNV Loss 18451855

Relevant External Links for SUGP2 Gene

HapMap Linkage Disequilibrium report
SUGP2

Disorders for SUGP2 Gene

No disorders were found for SUGP2 Gene.

No data available for UniProtKB/Swiss-Prot for SUGP2 Gene

Publications for SUGP2 Gene

  1. SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. (PMID: 12594045) Sampson N.D. … Hewitt J.E. (Gene 2003) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Phosphoproteome analysis of the human mitotic spindle. (PMID: 16565220) Nousiainen M. … KAPrner R. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3

Products for SUGP2 Gene

Sources for SUGP2 Gene

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