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Aliases for SUGP2 Gene

Aliases for SUGP2 Gene

  • SURP And G-Patch Domain Containing 2 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 14 2 3 4
  • Arginine/Serine-Rich-Splicing Factor 14 3 4
  • SFRS14 3 4
  • SURP And G-Patch Domain-Containing Protein 2 3
  • KIAA0365 4

External Ids for SUGP2 Gene

Previous HGNC Symbols for SUGP2 Gene

  • SFRS14

Previous GeneCards Identifiers for SUGP2 Gene

  • GC19M019103
  • GC19M018665

Summaries for SUGP2 Gene

Entrez Gene Summary for SUGP2 Gene

  • This gene encodes a member of the arginine/serine-rich family of splicing factors. The encoded protein functions in mRNA processing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GeneCards Summary for SUGP2 Gene

SUGP2 (SURP And G-Patch Domain Containing 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SUGP1.

UniProtKB/Swiss-Prot for SUGP2 Gene

  • May play a role in mRNA splicing.

Gene Wiki entry for SUGP2 Gene

Additional gene information for SUGP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUGP2 Gene

Genomics for SUGP2 Gene

Regulatory Elements for SUGP2 Gene


Enhancers around SUGP2 on UCSC Golden Path with GeneCards custom track

Promoters for SUGP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108181 523 2201 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 SLC30A9 ZNF143 ZNF207 FOS

Genomic Location for SUGP2 Gene

Chromosome:
19
Start:
18,990,888 bp from pter
End:
19,034,023 bp from pter
Size:
43,136 bases
Orientation:
Minus strand

Genomic View for SUGP2 Gene

Genes around SUGP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUGP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUGP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUGP2 Gene

Proteins for SUGP2 Gene

  • Protein details for SUGP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX01-SUGP2_HUMAN
    Recommended name:
    SURP and G-patch domain-containing protein 2
    Protein Accession:
    Q8IX01
    Secondary Accessions:
    • C9JI71
    • O15071
    • O60369
    • Q5JPH7
    • Q8WUF7

    Protein attributes for SUGP2 Gene

    Size:
    1082 amino acids
    Molecular mass:
    120207 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC06129.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH20586.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA20820.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SUGP2 Gene

    Alternative splice isoforms for SUGP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUGP2 Gene

Post-translational modifications for SUGP2 Gene

  • Ubiquitination at posLast=137137, Lys228, Lys305, posLast=595595, posLast=650650, and Lys673
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SUGP2 Gene

Domains & Families for SUGP2 Gene

Gene Families for SUGP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SUGP2 Gene

Suggested Antigen Peptide Sequences for SUGP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SUGP2: view

No data available for UniProtKB/Swiss-Prot for SUGP2 Gene

Function for SUGP2 Gene

Molecular function for SUGP2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in mRNA splicing.

Phenotypes From GWAS Catalog for SUGP2 Gene

Gene Ontology (GO) - Molecular Function for SUGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,IDA 22658674
genes like me logo Genes that share ontologies with SUGP2: view
genes like me logo Genes that share phenotypes with SUGP2: view

Animal Model Products

CRISPR Products

miRNA for SUGP2 Gene

miRTarBase miRNAs that target SUGP2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SUGP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUGP2 Gene

Localization for SUGP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUGP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUGP2 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SUGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with SUGP2: view

Pathways & Interactions for SUGP2 Gene

SuperPathways for SUGP2 Gene

SuperPathway Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with SUGP2: view

Pathways by source for SUGP2 Gene

1 BioSystems pathway for SUGP2 Gene

Gene Ontology (GO) - Biological Process for SUGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SUGP2: view

No data available for SIGNOR curated interactions for SUGP2 Gene

Drugs & Compounds for SUGP2 Gene

No Compound Related Data Available

Transcripts for SUGP2 Gene

Unigene Clusters for SUGP2 Gene

SURP and G patch domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SUGP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SUGP2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^
SP1:
SP2: - -
SP3: - -
SP4:
SP5: - - -
SP6: -
SP7:
SP8:
SP9: -
SP10:
SP11:

ExUns: 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SUGP2 Gene

GeneLoc Exon Structure for
SUGP2
ECgene alternative splicing isoforms for
SUGP2

Expression for SUGP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUGP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SUGP2 Gene

This gene is overexpressed in Testis (36.6), Liver (10.7), and Fetal Brain (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUGP2 Gene



Protein tissue co-expression partners for SUGP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SUGP2 Gene:

SUGP2

SOURCE GeneReport for Unigene cluster for SUGP2 Gene:

Hs.515271

mRNA Expression by UniProt/SwissProt for SUGP2 Gene:

Q8IX01-SUGP2_HUMAN
Tissue specificity: Detected in adult testis, and in fetal brain and kidney.

Evidence on tissue expression from TISSUES for SUGP2 Gene

  • Nervous system(5)
  • Intestine(4.3)
  • Liver(4.3)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with SUGP2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUGP2 Gene

Orthologs for SUGP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUGP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUGP2 33 34
  • 96.42 (n)
dog
(Canis familiaris)
Mammalia SUGP2 33 34
  • 87.52 (n)
cow
(Bos Taurus)
Mammalia SUGP2 33 34
  • 86.83 (n)
mouse
(Mus musculus)
Mammalia Sugp2 33 16 34
  • 77.45 (n)
rat
(Rattus norvegicus)
Mammalia Sugp2 33
  • 76.76 (n)
oppossum
(Monodelphis domestica)
Mammalia SUGP2 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUGP2 34
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUGP2 33 34
  • 63.01 (n)
lizard
(Anolis carolinensis)
Reptilia SUGP2 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19689 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.29339 33
fruit fly
(Drosophila melanogaster)
Insecta CG31550 34
  • 12 (a)
OneToMany
Species where no ortholog for SUGP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SUGP2 Gene

ENSEMBL:
Gene Tree for SUGP2 (if available)
TreeFam:
Gene Tree for SUGP2 (if available)

Paralogs for SUGP2 Gene

Paralogs for SUGP2 Gene

(1) SIMAP similar genes for SUGP2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SUGP2: view

Variants for SUGP2 Gene

Sequence variations from dbSNP and Humsavar for SUGP2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000002236 -- 19,031,960(+) TCACA(A/G)GTGTG intron-variant, upstream-variant-2KB
rs1000034789 -- 19,032,282(+) GCCTC(C/T)TGAGT intron-variant, upstream-variant-2KB
rs1000156347 -- 19,026,112(+) TCAGG(C/G)CTTCT nc-transcript-variant, reference, missense
rs1000166045 -- 19,014,619(+) AACCC(A/G)TTTCT intron-variant
rs1000218289 -- 19,008,690(+) CTTGG(A/G)GGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUGP2 Gene

Variant ID Type Subtype PubMed ID
nsv1059305 CNV loss 25217958
nsv1151217 CNV deletion 26484159
nsv2435 CNV deletion 18451855
nsv833778 CNV loss 17160897

Variation tolerance for SUGP2 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.27; 52.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUGP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUGP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUGP2 Gene

Disorders for SUGP2 Gene

Relevant External Links for SUGP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUGP2

No disorders were found for SUGP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUGP2 Gene

Publications for SUGP2 Gene

  1. SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. (PMID: 12594045) Sampson ND … Hewitt JE (Gene 2003) 2 3 4 22 60
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for SUGP2 Gene

Sources for SUGP2 Gene

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