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Aliases for SUGP2 Gene

Aliases for SUGP2 Gene

  • SURP And G-Patch Domain Containing 2 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 14 2 3 4
  • Arginine/Serine-Rich-Splicing Factor 14 3 4
  • SFRS14 3 4
  • KIAA0365 4

External Ids for SUGP2 Gene

Previous HGNC Symbols for SUGP2 Gene

  • SFRS14

Previous GeneCards Identifiers for SUGP2 Gene

  • GC19M019103
  • GC19M018665

Summaries for SUGP2 Gene

Entrez Gene Summary for SUGP2 Gene

  • This gene encodes a member of the arginine/serine-rich family of splicing factors. The encoded protein functions in mRNA processing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GeneCards Summary for SUGP2 Gene

SUGP2 (SURP And G-Patch Domain Containing 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SUGP1.

UniProtKB/Swiss-Prot for SUGP2 Gene

  • May play a role in mRNA splicing.

Gene Wiki entry for SUGP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUGP2 Gene

Genomics for SUGP2 Gene

Regulatory Elements for SUGP2 Gene

Promoters for SUGP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUGP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUGP2 Gene

Chromosome:
19
Start:
18,990,888 bp from pter
End:
19,034,023 bp from pter
Size:
43,136 bases
Orientation:
Minus strand

Genomic View for SUGP2 Gene

Genes around SUGP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUGP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUGP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUGP2 Gene

Proteins for SUGP2 Gene

  • Protein details for SUGP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX01-SUGP2_HUMAN
    Recommended name:
    SURP and G-patch domain-containing protein 2
    Protein Accession:
    Q8IX01
    Secondary Accessions:
    • C9JI71
    • O15071
    • O60369
    • Q5JPH7
    • Q8WUF7

    Protein attributes for SUGP2 Gene

    Size:
    1082 amino acids
    Molecular mass:
    120207 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC06129.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH20586.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA20820.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SUGP2 Gene

    Alternative splice isoforms for SUGP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUGP2 Gene

Proteomics data for SUGP2 Gene at MOPED

Post-translational modifications for SUGP2 Gene

  • Ubiquitination at Lys 137, Lys 228, Lys 305, Lys 595, Lys 650, and Lys 673
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SUGP2 Gene

Domains & Families for SUGP2 Gene

Gene Families for SUGP2 Gene

Protein Domains for SUGP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SUGP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IX01

UniProtKB/Swiss-Prot:

SUGP2_HUMAN :
  • Contains 1 G-patch domain.
  • Contains 2 SURP motif repeats.
Domain:
  • Contains 1 G-patch domain.
Similarity:
  • Contains 2 SURP motif repeats.
genes like me logo Genes that share domains with SUGP2: view

Function for SUGP2 Gene

Molecular function for SUGP2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in mRNA splicing.

Phenotypes for SUGP2 Gene

genes like me logo Genes that share phenotypes with SUGP2: view

Animal Model Products

CRISPR Products

miRNA for SUGP2 Gene

miRTarBase miRNAs that target SUGP2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUGP2 Gene

Localization for SUGP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUGP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUGP2 Gene COMPARTMENTS Subcellular localization image for SUGP2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for SUGP2 Gene

Pathways & Interactions for SUGP2 Gene

SuperPathways for SUGP2 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with SUGP2: view

Pathways by source for SUGP2 Gene

1 BioSystems pathway for SUGP2 Gene

Gene Ontology (GO) - Biological Process for SUGP2 Gene

None

No data available for SIGNOR curated interactions for SUGP2 Gene

Drugs & Compounds for SUGP2 Gene

No Compound Related Data Available

Transcripts for SUGP2 Gene

Unigene Clusters for SUGP2 Gene

SURP and G patch domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUGP2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^
SP1:
SP2: - -
SP3: - -
SP4:
SP5: - - -
SP6: -
SP7:
SP8:
SP9: -
SP10:
SP11:

ExUns: 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SUGP2 Gene

GeneLoc Exon Structure for
SUGP2
ECgene alternative splicing isoforms for
SUGP2

Expression for SUGP2 Gene

mRNA expression in normal human tissues for SUGP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SUGP2 Gene

This gene is overexpressed in Testis (36.6), Liver (10.7), and Fetal Brain (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUGP2 Gene



SOURCE GeneReport for Unigene cluster for SUGP2 Gene Hs.515271

mRNA Expression by UniProt/SwissProt for SUGP2 Gene

Q8IX01-SUGP2_HUMAN
Tissue specificity: Detected in adult testis, and in fetal brain and kidney.
genes like me logo Genes that share expression patterns with SUGP2: view

Protein tissue co-expression partners for SUGP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SUGP2 Gene

Orthologs for SUGP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUGP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUGP2 35
  • 86.83 (n)
  • 85.81 (a)
SUGP2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUGP2 35
  • 87.52 (n)
  • 87.77 (a)
SUGP2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sugp2 35
  • 77.45 (n)
  • 75.97 (a)
Sugp2 16
Sugp2 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUGP2 35
  • 96.42 (n)
  • 95.65 (a)
SUGP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sugp2 35
  • 76.76 (n)
  • 75.5 (a)
oppossum
(Monodelphis domestica)
Mammalia SUGP2 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUGP2 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUGP2 35
  • 63.01 (n)
  • 59.18 (a)
SUGP2 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUGP2 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19689 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.29339 35
fruit fly
(Drosophila melanogaster)
Insecta CG31550 36
  • 12 (a)
OneToMany
Species with no ortholog for SUGP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SUGP2 Gene

ENSEMBL:
Gene Tree for SUGP2 (if available)
TreeFam:
Gene Tree for SUGP2 (if available)

Paralogs for SUGP2 Gene

Paralogs for SUGP2 Gene

(1) SIMAP similar genes for SUGP2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SUGP2: view

Variants for SUGP2 Gene

Sequence variations from dbSNP and Humsavar for SUGP2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs4808907 - 19,025,732(+) ACTGC(C/T)GCCCC nc-transcript-variant, reference, missense
rs10404860 - 19,024,693(+) CTCGC(A/G)TCGGC nc-transcript-variant, reference, missense
rs10414535 - 19,010,247(+) GCTTC(C/T)GGTCG nc-transcript-variant, reference, missense
rs34540303 - 19,010,028(+) TTGCC(C/T)GTGAG nc-transcript-variant, reference, missense
rs35646935 - 19,004,455(+) CCTCC(C/T)GCGGA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SUGP2 Gene

Variant ID Type Subtype PubMed ID
nsv833778 CNV Loss 17160897
nsv2435 CNV Loss 18451855

Variation tolerance for SUGP2 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.27; 52.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUGP2 Gene

HapMap Linkage Disequilibrium report
SUGP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUGP2 Gene

Disorders for SUGP2 Gene

Relevant External Links for SUGP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUGP2

No disorders were found for SUGP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUGP2 Gene

Publications for SUGP2 Gene

  1. SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. (PMID: 12594045) Sampson N.D. … Hewitt J.E. (Gene 2003) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  4. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3
  5. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3

Products for SUGP2 Gene

Sources for SUGP2 Gene

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