Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SUGP2 Gene

Aliases for SUGP2 Gene

  • SURP And G Patch Domain Containing 2 2 3
  • Splicing Factor, Arginine/Serine-Rich 14 2 3 4
  • Arginine/Serine-Rich-Splicing Factor 14 3 4
  • KIAA0365 4 6
  • SFRS14 3 4
  • Putative Splicing Factor, Arginine/Serine-Rich 14 3
  • SURP And G-Patch Domain-Containing Protein 2 3
  • Arginine/Serine-Rich 14 Splicing Factor 3
  • SRFS14 6

External Ids for SUGP2 Gene

Previous HGNC Symbols for SUGP2 Gene

  • SFRS14

Previous GeneCards Identifiers for SUGP2 Gene

  • GC19M019103
  • GC19M018665

Summaries for SUGP2 Gene

Entrez Gene Summary for SUGP2 Gene

  • This gene encodes a member of the arginine/serine-rich family of splicing factors. The encoded protein functions in mRNA processing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GeneCards Summary for SUGP2 Gene

SUGP2 (SURP And G Patch Domain Containing 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding. An important paralog of this gene is SUGP1.

UniProtKB/Swiss-Prot for SUGP2 Gene

  • May play a role in mRNA splicing.

Gene Wiki entry for SUGP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUGP2 Gene

Genomics for SUGP2 Gene

Genomic Location for SUGP2 Gene

18,990,888 bp from pter
19,034,038 bp from pter
43,151 bases
Minus strand

Genomic View for SUGP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUGP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUGP2 Gene

No data available for Regulatory Elements for SUGP2 Gene

Proteins for SUGP2 Gene

  • Protein details for SUGP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SURP and G-patch domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • C9JI71
    • O15071
    • O60369
    • Q5JPH7
    • Q8WUF7

    Protein attributes for SUGP2 Gene

    1082 amino acids
    Molecular mass:
    120207 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC06129.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH20586.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA20820.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SUGP2 Gene

    Alternative splice isoforms for SUGP2 Gene


neXtProt entry for SUGP2 Gene

Proteomics data for SUGP2 Gene at MOPED

Post-translational modifications for SUGP2 Gene

  • Ubiquitination at Lys137, Lys228, Lys305, Lys595, Lys650, and Lys673
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SUGP2 Gene

Domains for SUGP2 Gene

Gene Families for SUGP2 Gene

  • GPATCH :G patch domain containing

Protein Domains for SUGP2 Gene


Suggested Antigen Peptide Sequences for SUGP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8IX01
  • Contains 1 G-patch domain.
  • Contains 2 SURP motif repeats.
genes like me logo Genes that share domains with SUGP2: view

Function for SUGP2 Gene

Molecular function for SUGP2 Gene

UniProtKB/Swiss-Prot Function: May play a role in mRNA splicing.

Gene Ontology (GO) - Molecular Function for SUGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SUGP2: view

Phenotypes for SUGP2 Gene

GenomeRNAi human phenotypes for SUGP2:
genes like me logo Genes that share phenotypes with SUGP2: view

Animal Model Products

CRISPR Products

miRNA for SUGP2 Gene

miRTarBase miRNAs that target SUGP2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SUGP2 Gene

Localization for SUGP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUGP2 Gene

Subcellular locations from

Jensen Localization Image for SUGP2 Gene COMPARTMENTS Subcellular localization image for SUGP2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for SUGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SUGP2: view

Pathways for SUGP2 Gene

SuperPathways for SUGP2 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with SUGP2: view

Pathways by source for SUGP2 Gene

1 BioSystems pathway for SUGP2 Gene

Gene Ontology (GO) - Biological Process for SUGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SUGP2: view

Transcripts for SUGP2 Gene

Unigene Clusters for SUGP2 Gene

SURP and G patch domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUGP2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SUGP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUGP2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^
SP2: - -
SP3: - -
SP5: - - -
SP6: -
SP9: -

ExUns: 15 ^ 16

Relevant External Links for SUGP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SUGP2 Gene

mRNA expression in normal human tissues for SUGP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUGP2 Gene

SOURCE GeneReport for Unigene cluster for SUGP2 Gene Hs.515271

mRNA Expression by UniProt/SwissProt for SUGP2 Gene

Tissue specificity: Detected in adult testis, and in fetal brain and kidney.
genes like me logo Genes that share expressions with SUGP2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SUGP2 Gene

Orthologs for SUGP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUGP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SUGP2 35
  • 96.42 (n)
  • 95.65 (a)
SUGP2 36
  • 99 (a)
(Bos Taurus)
Mammalia SUGP2 35
  • 86.83 (n)
  • 85.81 (a)
SUGP2 36
  • 84 (a)
(Canis familiaris)
Mammalia SUGP2 35
  • 87.52 (n)
  • 87.77 (a)
SUGP2 36
  • 85 (a)
(Mus musculus)
Mammalia Sugp2 35
  • 77.45 (n)
  • 75.97 (a)
Sugp2 16
Sugp2 36
  • 73 (a)
(Monodelphis domestica)
Mammalia SUGP2 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia SUGP2 36
  • 54 (a)
(Rattus norvegicus)
Mammalia Sugp2 35
  • 76.76 (n)
  • 75.5 (a)
(Gallus gallus)
Aves SUGP2 35
  • 63.01 (n)
  • 59.18 (a)
SUGP2 36
  • 51 (a)
(Anolis carolinensis)
Reptilia SUGP2 36
  • 52 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29339 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19689 35
fruit fly
(Drosophila melanogaster)
Insecta CG31550 36
  • 12 (a)
Species with no ortholog for SUGP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SUGP2 Gene

Gene Tree for SUGP2 (if available)
Gene Tree for SUGP2 (if available)

Paralogs for SUGP2 Gene

Paralogs for SUGP2 Gene

Selected SIMAP similar genes for SUGP2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SUGP2: view

Variants for SUGP2 Gene

Sequence variations from dbSNP and Humsavar for SUGP2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs12016 -- 18,991,781(-) TCATC(A/T)TCTCC intron-variant, nc-transcript-variant
rs1079543 -- 19,007,124(+) CACCC(C/T)GGGGA intron-variant
rs1124921 -- 19,006,593(-) TTTCA(C/T)TTTCT intron-variant
rs1137624 -- 18,992,188(-) ttgta(A/G)tccca downstream-variant-500B, intron-variant, nc-transcript-variant
rs1859267 -- 19,013,241(+) TTCAC(A/T)ATCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUGP2 Gene

Variant ID Type Subtype PubMed ID
nsv833778 CNV Loss 17160897
nsv2435 CNV Loss 18451855

Relevant External Links for SUGP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUGP2 Gene

Disorders for SUGP2 Gene

No disorders were found for SUGP2 Gene.

No data available for UniProtKB/Swiss-Prot for SUGP2 Gene

Publications for SUGP2 Gene

  1. SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. (PMID: 12594045) Sampson N.D. … Hewitt J.E. (Gene 2003) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Phosphoproteome analysis of the human mitotic spindle. (PMID: 16565220) Nousiainen M. … KAPrner R. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3

Products for SUGP2 Gene

Sources for SUGP2 Gene

Back to Top