Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SUGP1 Gene

Aliases for SUGP1 Gene

  • SURP And G Patch Domain Containing 1 2 3
  • Splicing Factor 4 2 3 4
  • SF4 3 4 6
  • RNA-Binding Protein RBP 3 4
  • SURP And G-Patch Domain-Containing Protein 1 3
  • F23858 3
  • RBP 3

External Ids for SUGP1 Gene

Previous HGNC Symbols for SUGP1 Gene

  • SF4

Previous GeneCards Identifiers for SUGP1 Gene

  • GC19M019389
  • GC19M018951

Summaries for SUGP1 Gene

Entrez Gene Summary for SUGP1 Gene

  • SF4 is a member of the SURP family of splicing factors.[supplied by OMIM, Sep 2003]

GeneCards Summary for SUGP1 Gene

SUGP1 (SURP And G Patch Domain Containing 1) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding. An important paralog of this gene is SUGP2.

UniProtKB/Swiss-Prot for SUGP1 Gene

  • Plays a role in pre-mRNA splicing

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUGP1 Gene

Genomics for SUGP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SUGP1 Gene

Start:
19,276,018 bp from pter
End:
19,320,844 bp from pter
Size:
44,827 bases
Orientation:
Minus strand

Genomic View for SUGP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUGP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUGP1 Gene

No data available for Regulatory Elements for SUGP1 Gene

Proteins for SUGP1 Gene

  • Protein details for SUGP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWZ8-SUGP1_HUMAN
    Recommended name:
    SURP and G-patch domain-containing protein 1
    Protein Accession:
    Q8IWZ8
    Secondary Accessions:
    • O60378
    • Q6P3X9
    • Q8TCQ4
    • Q8WWT4
    • Q8WWT5
    • Q9NTG3

    Protein attributes for SUGP1 Gene

    Size:
    645 amino acids
    Molecular mass:
    72471 Da
    Quaternary structure:
    • Component of the spliceosome.
    SequenceCaution:
    • Sequence=AAC08052.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAL68960.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL68961.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SUGP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUGP1 Gene

Proteomics data for SUGP1 Gene at MOPED

Post-translational modifications for SUGP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SUGP1 Gene

No data available for DME Specific Peptides for SUGP1 Gene

Domains for SUGP1 Gene

Gene Families for SUGP1 Gene

HGNC:
  • GPATCH :G patch domain containing

Protein Domains for SUGP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SUGP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWZ8

UniProtKB/Swiss-Prot:

SUGP1_HUMAN :
  • Q8IWZ8
Domain:
  • Contains 1 G-patch domain.
Similarity:
  • Contains 2 SURP motif repeats.
genes like me logo Genes that share domains with SUGP1: view

Function for SUGP1 Gene

Molecular function for SUGP1 Gene

UniProtKB/Swiss-Prot Function: Plays a role in pre-mRNA splicing

Gene Ontology (GO) - Molecular Function for SUGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 21988832
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with SUGP1: view

Phenotypes for SUGP1 Gene

GenomeRNAi human phenotypes for SUGP1:
genes like me logo Genes that share phenotypes with SUGP1: view

Animal Model Products

CRISPR Products

miRNA for SUGP1 Gene

miRTarBase miRNAs that target SUGP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUGP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SUGP1 Gene

Localization for SUGP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUGP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUGP1 Gene COMPARTMENTS Subcellular localization image for SUGP1 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SUGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
genes like me logo Genes that share ontologies with SUGP1: view

Pathways for SUGP1 Gene

genes like me logo Genes that share pathways with SUGP1: view

Pathways by source for SUGP1 Gene

Gene Ontology (GO) - Biological Process for SUGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006396 RNA processing --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SUGP1: view

Transcripts for SUGP1 Gene

Unigene Clusters for SUGP1 Gene

SURP and G patch domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUGP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SUGP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUGP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -
SP2:
SP3:
SP4: - - - - - - - - - - - -
SP5:
SP6:

Relevant External Links for SUGP1 Gene

GeneLoc Exon Structure for
SUGP1
ECgene alternative splicing isoforms for
SUGP1

Expression for SUGP1 Gene

mRNA expression in normal human tissues for SUGP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUGP1 Gene

SOURCE GeneReport for Unigene cluster for SUGP1 Gene Hs.515274

mRNA Expression by UniProt/SwissProt for SUGP1 Gene

Q8IWZ8-SUGP1_HUMAN
Tissue specificity: Detected in adult testis and heart, and in adult and fetal brain, kidney and skeletal muscle.
genes like me logo Genes that share expressions with SUGP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SUGP1 Gene

Orthologs for SUGP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUGP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUGP1 35
  • 99.53 (n)
  • 99.84 (a)
SUGP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SF4 36
  • 91 (a)
OneToOne
SUGP1 35
  • 90.03 (n)
  • 91.34 (a)
dog
(Canis familiaris)
Mammalia SUGP1 35
  • 89.4 (n)
  • 92.6 (a)
SUGP1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sugp1 35
  • 85.34 (n)
  • 88.92 (a)
Sugp1 16
Sugp1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUGP1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUGP1 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sugp1 35
  • 84.97 (n)
  • 88.46 (a)
chicken
(Gallus gallus)
Aves SUGP1 35
  • 74.95 (n)
  • 78.01 (a)
SUGP1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUGP1 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4572 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16120 35
sugp1 35
  • 66.61 (n)
  • 68.24 (a)
zebrafish
(Danio rerio)
Actinopterygii sugp1 35
  • 69.16 (n)
  • 66.55 (a)
sugp1 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31550 36
  • 17 (a)
OneToMany
Species with no ortholog for SUGP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUGP1 Gene

ENSEMBL:
Gene Tree for SUGP1 (if available)
TreeFam:
Gene Tree for SUGP1 (if available)

Paralogs for SUGP1 Gene

Paralogs for SUGP1 Gene

Selected SIMAP similar genes for SUGP1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SUGP1 Gene

genes like me logo Genes that share paralogs with SUGP1: view

Variants for SUGP1 Gene

Sequence variations from dbSNP and Humsavar for SUGP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs739846 -- 19,308,262(-) GAGCT(C/T)GGGAA intron-variant
rs757346 -- 19,276,376(+) AAACA(A/G)CTTTC downstream-variant-500B
rs1010207 -- 19,305,236(-) GTGTG(A/G)AGGGC intron-variant
rs1044980 - 19,277,811(-) TACCA(C/G)ATGCT missense, reference
rs1045003 -- 19,276,625(-) ACTTT(C/T)TGAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SUGP1 Gene

Variant ID Type Subtype PubMed ID
nsv911303 CNV Loss 21882294
nsv911304 CNV Loss 21882294
nsv911305 CNV Loss 21882294
nsv911306 CNV Loss 21882294
esv2664832 CNV Deletion 23128226

Relevant External Links for SUGP1 Gene

HapMap Linkage Disequilibrium report
SUGP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUGP1 Gene

Disorders for SUGP1 Gene

Relevant External Links for SUGP1

Genetic Association Database (GAD)
SUGP1
Human Genome Epidemiology (HuGE) Navigator
SUGP1
genes like me logo Genes that share disorders with SUGP1: view

No data available for UniProtKB/Swiss-Prot for SUGP1 Gene

Publications for SUGP1 Gene

  1. SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. (PMID: 12594045) Sampson N.D. … Hewitt J.E. (Gene 2003) 2 3 4 23
  2. Large-scale proteomic analysis of the human spliceosome. (PMID: 12176931) Rappsilber J. … Mann M. (Genome Res. 2002) 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 48

Products for SUGP1 Gene

Sources for SUGP1 Gene

Back to Top

Content