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SUGP1 Gene

protein-coding   GIFtS: 54
GCID: GC19M019389

SURP And G Patch Domain Containing 1

(Previous name: splicing factor 4)
(Previous symbol: SF4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SURP And G Patch Domain Containing 11 2     F238582
SF41 2 3 5     RBP2
Splicing Factor 41 2 3     SURP And G-Patch Domain-Containing Protein 12
RNA-Binding Protein RBP2 3     

External Ids:    HGNC: 186431   Entrez Gene: 577942   Ensembl: ENSG000001057057   OMIM: 6079925   UniProtKB: Q8IWZ83   

Export aliases for SUGP1 gene to outside databases

Previous GC identifer: GC19M018951


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SUGP1 Gene:
SF4 is a member of the SURP family of splicing factors.(supplied by OMIM, Sep 2003)

GeneCards Summary for SUGP1 Gene:
SUGP1 (SURP and G patch domain containing 1) is a protein-coding gene. Diseases associated with SUGP1 include acquired immunodeficiency syndrome, and estrogen-receptor positive breast cancer. GO annotations related to this gene include RNA binding. An important paralog of this gene is SUGP2.

UniProtKB/Swiss-Prot: SUGP1_HUMAN, Q8IWZ8
Function: Plays a role in pre-mRNA splicing




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SUGP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUGP1 promoter sequence
   Search Chromatin IP Primers for SUGP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUGP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13

SUGP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUGP1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M019389:  view genomic region     (about GC identifiers)

Start:
19,386,827 bp from pter      End:
19,431,653 bp from pter
Size:
44,827 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SUGP1_HUMAN, Q8IWZ8 (See protein sequence)
Recommended Name: SURP and G-patch domain-containing protein 1  
Size: 645 amino acids; 72471 Da
Subunit: Component of the spliceosome
Sequence caution: Sequence=AAC08052.1; Type=Erroneous gene model prediction; Sequence=AAL68960.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAL68961.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: O60378 Q6P3X9 Q8TCQ4 Q8WWT4 Q8WWT5 Q9NTG3
Alternative splicing: 2 isoforms:  Q8IWZ8-1   Q8IWZ8-2   

Explore the universe of human proteins at neXtProt for SUGP1: NX_Q8IWZ8

Explore proteomics data for SUGP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SUGP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_757386.2  
    ENSEMBL proteins: 
     ENSP00000466402   ENSP00000247001   ENSP00000465413   ENSP00000466188   ENSP00000439172  
     ENSP00000477290   ENSP00000468499   ENSP00000468771   ENSP00000334032  
    Reactome Protein details: Q8IWZ8

    SUGP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SUGP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for SUGP1
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SUGP1
    LSBio Antibodies in human, mouse, rat for SUGP1

    SUGP1 Assay Products:

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    GenScript Custom Assay Services for SUGP1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPATCH: G patch domain containing

    2 InterPro protein domains:
     IPR000467 G_patch_dom
     IPR000061 Surp

    Graphical View of Domain Structure for InterPro Entry Q8IWZ8

    ProtoNet protein and cluster: Q8IWZ8

    1 Blocks protein domain: IPB000467 D111/G-patch domain

    UniProtKB/Swiss-Prot: SUGP1_HUMAN, Q8IWZ8
    Similarity: Contains 1 G-patch domain
    Similarity: Contains 2 SURP motif repeats


    SUGP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUGP1_HUMAN, Q8IWZ8
    Function: Plays a role in pre-mRNA splicing

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    SUGP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SUGP1:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SUGP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SUGP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUGP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUGP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SUGP1:
    hsa-mir-1 (MIRT023869), hsa-mir-92a-3p (MIRT049813)

    Block miRNA regulation of human, mouse, rat SUGP1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SUGP1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SUGP1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SUGP1

    Clone
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    OriGene ORF clones in mouse, rat for SUGP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SUGP1 (NM_172231)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUGP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUGP1

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUGP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SUGP1_HUMAN, Q8IWZ8: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IEA--

    SUGP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SUGP1 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SUGP1
        mRNA processing

    1 Reactome Pathway for SUGP1
        mRNA Splicing - Major Pathway



    SUGP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SUGP1
    Interactions:

        Search GeneGlobe Interaction Network for SUGP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SUGP1 (Q8IWZ81, 2, 3 ENSP000002470014) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHX15O431431, 2, ENSP000003367414EBI-2691671,EBI-1237044 MINT-8334021 MINT-8331767 STRING: ENSP00000336741
    SF3A2Q154282, 3, ENSP000002214944MINT-5206052 I2D: score=1 STRING: ENSP00000221494
    RBM17Q96I251, 2, ENSP000003692184EBI-2691671,EBI-740272 MINT-8334087 MINT-8332504 STRING: ENSP00000369218
    U2AF2P263681, 2, ENSP000003078634EBI-2691671,EBI-742339 MINT-8334197 MINT-8332581 STRING: ENSP00000307863
    RBM10P981751, 2, ENSP000003668294EBI-2691671,EBI-721525 MINT-8332185 MINT-8334890 STRING: ENSP00000366829
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006396RNA processing ----
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    SUGP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SUGP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SUGP1 gene (3 alternative transcripts): 
    NM_021164.2  NM_182812.1  NM_172231.3  

    Unigene Cluster for SUGP1:

    SURP and G patch domain containing 1
    Hs.515274  [show with all ESTs]
    Unigene Representative Sequence: AY072916
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589144 ENST00000247001(uc002nme.3 uc002nmf.3 uc002nmg.3 uc002nmh.3 uc002nmi.3 uc002nmj.3 uc010xqr.2)
    ENST00000591007 ENST00000588731 ENST00000587119 ENST00000592188 ENST00000585763
    ENST00000586387 ENST00000535070(uc010xqs.2) ENST00000590439 ENST00000591350
    ENST00000606725 ENST00000587716 ENST00000588580 ENST00000585444 ENST00000334782

    miRNA
    Products:
         
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    Search for qRT-PCR Assays for microRNAs that regulate SUGP1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SUGP1
    Predesigned siRNA for gene silencing in human, mouse, rat SUGP1
    Clone
    Products:
         
    OriGene clones in human, mouse for SUGP1 (see all 6)
    OriGene ORF clones in mouse, rat for SUGP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SUGP1 (NM_172231)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUGP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUGP1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SUGP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SUGP1
      QuantiTect SYBR Green Assays in human, mouse, rat SUGP1
      QuantiFast Probe-based Assays in human, mouse, rat SUGP1

    Additional mRNA sequence: 

    AF521128.1 AK092745.1 AK292085.1 AK294618.1 AK301119.1 AL137286.1 AL713757.1 AY072916.1 
    AY072917.1 BC001043.2 BC002986.1 BC063784.1 BC119728.1 BC119729.1 BC142988.1 

    20 DOTS entries:

    DT.92434968  DT.100811580  DT.100811589  DT.102836428  DT.95075334  DT.121492546  DT.121492886  DT.121492969 
    DT.100811584  DT.92001136  DT.100811588  DT.102836427  DT.121492639  DT.121492800  DT.121492887  DT.95198640 
    DT.95240652  DT.100811583  DT.120832029  DT.121492814 

    Selected AceView cDNA sequences (see all 216):

    AI431893 AK092745 CB851075 NM_172231 BE745790 CR593392 AL549997 CR606492 
    BU944141 CR607324 CB153618 BG109463 AI380613 BU786735 AW411453 CB994656 
    BQ956578 BM835762 CB155043 BG675979 NM_182812 AI453069 BQ016564 BU781590 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SUGP1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                -                             -                                                               
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                          -     -     -     -     -     -     -     -     -     -     -     -                                 
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for SUGP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SUGP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATGGATA
    SUGP1 Expression
    About this image

    SUGP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUGP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515274

    UniProtKB/Swiss-Prot: SUGP1_HUMAN, Q8IWZ8
    Tissue specificity: Detected in adult testis and heart, and in adult and fetal brain, kidney and skeletal muscle

        Custom PCR Arrays for SUGP1
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    QuantiFast Probe-based Assays in human, mouse, rat SUGP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUGP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUGP1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sugp11 , 5 SURP and G patch domain containing 11, 5 85.34(n)1
    88.92(a)1
      8 (34.15 cM)5
    706161  NM_027481.21  NP_081757.11 
     700428135 
    chicken
    (Gallus gallus)
    Aves SUGP11 SURP and G patch domain containing 1 74.95(n)
    78.01(a)
      428349  NM_001195551.1  NP_001182480.1 
    lizard
    (Anolis carolinensis)
    Reptilia SUGP16
    SURP and G patch domain containing 1
    73(a)
    1 ↔ 1
    AAWZ02038765(129-10444)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.45722 Xenopus laevis transcribed sequence with strong similarity more 77.95(n)    BX845977.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sugp11 SURP and G patch domain containing 1 69.16(n)
    66.55(a)
      100073344  XM_003197980.2  XP_003198028.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG315506
    --
    17(a)
    1 → many
    3R(1311254-1315211)
    soybean
    (Glycine max)
    eudicotyledons 468214002   -- 75(n)  


    ENSEMBL Gene Tree for SUGP1 (if available)
    TreeFam Gene Tree for SUGP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SUGP1 gene
    SUGP22  
    1 SIMAP similar gene for SUGP1 using alignment to 7 protein entries:     SUGP1_HUMAN (see all proteins):
    SF4

    SUGP1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SUGP1
    PGOHUM00000239853 PGOHUM00000235755


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SUGP1 (see all 874)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1118032081,2
    C,F--19387107(+) CGCCCG/ACCTTG 1 -- int12Minor allele frequency- A:0.50CSA 4
    rs20179641,2
    C,F,A--19387149(-) GGTGCA/GGTGTC 1 -- int1 ese312Minor allele frequency- G:0.43NA WA CSA EA 375
    rs7573461,2
    C,F,A,H--19387185(+) AAACAG/ACTTTC 1 -- int114Minor allele frequency- A:0.01NS EA NA WA CSA 637
    rs20105061,2
    C,F,A,H--19387356(-) GTGCCG/ATGCCG 1 -- ut31 ese318Minor allele frequency- A:0.19MN NS EA NA CSA WA 2068
    rs778834951,2
    C--19387382(+) GGGTGC/GGCAGA 1 -- ut310--------
    rs1828431971,2
    C--19387464(+) AGTAGG/TAAGGC 2 Y S mis10--------
    rs1453194401,2
    C--19387527(+) GCACTA/GAAGAC 1 -- int10--------
    rs608926611,2
    C--19387614(+) CGGGTG/TGGGGC 1 -- int10--------
    rs2014513401,2
    C,F--19387721(+) CTGTCG/AACTGA 1 -- int11Minor allele frequency- A:0.01EU 1318
    rs20745501,2
    C,F,A,H--19387743(+) CCAGGA/C/TGGACA 1 -- int131EA NS NA WA CSA EU 5316

    HapMap Linkage Disequilibrium report for SUGP1 (19386827 - 19431653 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SUGP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664832CNV Deletion23128226
    nsv911304CNV Loss21882294
    nsv911306CNV Loss21882294
    nsv911305CNV Loss21882294
    nsv911303CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607992    OMIM disorders: --

    11 diseases for SUGP1:    
    About MalaCards
    acquired immunodeficiency syndrome    estrogen-receptor positive breast cancer    hypertriglyceridemia    myotonic dystrophy
    muscular dystrophy    coronary artery disease    systemic lupus erythematosus    lupus erythematosus
    squamous cell carcinoma    breast cancer    neuronitis


    SUGP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SUGP1
    Human Genome Epidemiology (HuGE) Navigator: SUGP1 (0 documents)

    Export disorders for SUGP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUGP1 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with SUGP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. (PubMed id 12594045)1, 2, 3, 9 Sampson N.D. and Hewitt J.E. (Gene 2003)
    2. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PubMed id 20864672)1, 4 Waterworth D.M....Sandhu M.S. (Arterioscler. Thromb. Vasc. Biol. 2010)
    3. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)
    4. Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1, 4 Kathiresan S....Cupples L.A. (Nat. Genet. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    7. Large-scale proteomic analysis of the human spliceosome. (PubMed id 12176931)1, 2 Rappsilber J.... Mann M. (Genome Res. 2002)
    8. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PubMed id 23974872)1 Ripke S....Sullivan P.F. (Nat. Genet. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (J. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57794 HGNC: 18643 AceView: SF4 Ensembl:ENSG00000105705 euGenes: HUgn57794
    ECgene: SUGP1 H-InvDB: SUGP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SUGP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SUGP1 gene:
    Search GeneIP for patents involving SUGP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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