Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SUGP1 Gene

Aliases for SUGP1 Gene

  • SURP And G-Patch Domain Containing 1 2 3 5
  • Splicing Factor 4 2 3 4
  • RNA-Binding Protein RBP 3 4
  • SF4 3 4
  • SURP And G Patch Domain Containing 1 3
  • F23858 3
  • RBP 3

External Ids for SUGP1 Gene

Previous HGNC Symbols for SUGP1 Gene

  • SF4

Previous GeneCards Identifiers for SUGP1 Gene

  • GC19M019389
  • GC19M018951

Summaries for SUGP1 Gene

Entrez Gene Summary for SUGP1 Gene

  • SF4 is a member of the SURP family of splicing factors.[supplied by OMIM, Sep 2003]

GeneCards Summary for SUGP1 Gene

SUGP1 (SURP And G-Patch Domain Containing 1) is a Protein Coding gene. Diseases associated with SUGP1 include Carotenemia and Plexopathy. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SUGP2.

UniProtKB/Swiss-Prot for SUGP1 Gene

  • Plays a role in pre-mRNA splicing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUGP1 Gene

Genomics for SUGP1 Gene

Regulatory Elements for SUGP1 Gene

Enhancers for SUGP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SUGP1 on UCSC Golden Path with GeneCards custom track

Promoters for SUGP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUGP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUGP1 Gene

Chromosome:
19
Start:
19,276,018 bp from pter
End:
19,320,844 bp from pter
Size:
44,827 bases
Orientation:
Minus strand

Genomic View for SUGP1 Gene

Genes around SUGP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUGP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUGP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUGP1 Gene

Proteins for SUGP1 Gene

  • Protein details for SUGP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWZ8-SUGP1_HUMAN
    Recommended name:
    SURP and G-patch domain-containing protein 1
    Protein Accession:
    Q8IWZ8
    Secondary Accessions:
    • O60378
    • Q6P3X9
    • Q8TCQ4
    • Q8WWT4
    • Q8WWT5
    • Q9NTG3

    Protein attributes for SUGP1 Gene

    Size:
    645 amino acids
    Molecular mass:
    72471 Da
    Quaternary structure:
    • Component of the spliceosome.
    SequenceCaution:
    • Sequence=AAC08052.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAL68960.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL68961.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SUGP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUGP1 Gene

Proteomics data for SUGP1 Gene at MOPED

Post-translational modifications for SUGP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SUGP1 Gene

Domains & Families for SUGP1 Gene

Gene Families for SUGP1 Gene

Protein Domains for SUGP1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IWZ8

UniProtKB/Swiss-Prot:

SUGP1_HUMAN :
  • Contains 1 G-patch domain.
  • Contains 2 SURP motif repeats.
Domain:
  • Contains 1 G-patch domain.
Similarity:
  • Contains 2 SURP motif repeats.
genes like me logo Genes that share domains with SUGP1: view

Function for SUGP1 Gene

Molecular function for SUGP1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for SUGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SUGP1: view
genes like me logo Genes that share phenotypes with SUGP1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUGP1 Gene

Localization for SUGP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUGP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUGP1 Gene COMPARTMENTS Subcellular localization image for SUGP1 gene
Compartment Confidence
nucleus 5
cytosol 2
chloroplast 1
extracellular 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for SUGP1 Gene

Pathways & Interactions for SUGP1 Gene

genes like me logo Genes that share pathways with SUGP1: view

Pathways by source for SUGP1 Gene

Gene Ontology (GO) - Biological Process for SUGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
genes like me logo Genes that share ontologies with SUGP1: view

No data available for SIGNOR curated interactions for SUGP1 Gene

Drugs & Compounds for SUGP1 Gene

No Compound Related Data Available

Transcripts for SUGP1 Gene

Unigene Clusters for SUGP1 Gene

SURP and G patch domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUGP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -
SP2:
SP3:
SP4: - - - - - - - - - - - -
SP5:
SP6:

Relevant External Links for SUGP1 Gene

GeneLoc Exon Structure for
SUGP1
ECgene alternative splicing isoforms for
SUGP1

Expression for SUGP1 Gene

mRNA expression in normal human tissues for SUGP1 Gene

Protein differential expression in normal tissues from HIPED for SUGP1 Gene

This gene is overexpressed in Heart (20.8), CD8 Tcells (8.4), and Lymph node (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUGP1 Gene



SOURCE GeneReport for Unigene cluster for SUGP1 Gene Hs.515274

mRNA Expression by UniProt/SwissProt for SUGP1 Gene

Q8IWZ8-SUGP1_HUMAN
Tissue specificity: Detected in adult testis and heart, and in adult and fetal brain, kidney and skeletal muscle.
genes like me logo Genes that share expression patterns with SUGP1: view

Protein tissue co-expression partners for SUGP1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SUGP1 Gene

Orthologs for SUGP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUGP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUGP1 35
  • 90.03 (n)
  • 91.34 (a)
SF4 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUGP1 35
  • 89.4 (n)
  • 92.6 (a)
SUGP1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sugp1 35
  • 85.34 (n)
  • 88.92 (a)
Sugp1 16
Sugp1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUGP1 35
  • 99.53 (n)
  • 99.84 (a)
SUGP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sugp1 35
  • 84.97 (n)
  • 88.46 (a)
oppossum
(Monodelphis domestica)
Mammalia SUGP1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUGP1 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUGP1 35
  • 74.95 (n)
  • 78.01 (a)
SUGP1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUGP1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16120 35
sugp1 35
  • 66.61 (n)
  • 68.24 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4572 35
zebrafish
(Danio rerio)
Actinopterygii sugp1 35
  • 69.16 (n)
  • 66.55 (a)
sugp1 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31550 36
  • 17 (a)
OneToMany
Species with no ortholog for SUGP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUGP1 Gene

ENSEMBL:
Gene Tree for SUGP1 (if available)
TreeFam:
Gene Tree for SUGP1 (if available)

Paralogs for SUGP1 Gene

Paralogs for SUGP1 Gene

(1) SIMAP similar genes for SUGP1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SUGP1 Gene

genes like me logo Genes that share paralogs with SUGP1: view

Variants for SUGP1 Gene

Sequence variations from dbSNP and Humsavar for SUGP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs17751061 - 19,302,283(+) TCTCA(C/T)GGTTG reference, missense
rs1044980 - 19,277,811(-) TACCA(C/G)ATGCT reference, missense
rs757346 -- 19,276,376(+) AAACA(A/G)CTTTC downstream-variant-500B
rs7259434 -- 19,317,996(+) AGTAC(A/T)GTTAG intron-variant, upstream-variant-2KB
rs12976025 -- 19,318,411(+) cacca(C/T)accca intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SUGP1 Gene

Variant ID Type Subtype PubMed ID
nsv911303 CNV Loss 21882294
nsv911304 CNV Loss 21882294
nsv911305 CNV Loss 21882294
nsv911306 CNV Loss 21882294
esv2664832 CNV Deletion 23128226

Variation tolerance for SUGP1 Gene

Residual Variation Intolerance Score: 9.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.98; 74.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SUGP1 Gene

Disorders for SUGP1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SUGP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
carotenemia
  • hypercarotinemia
plexopathy
keratomalacia
  • night blindness
brachial plexus lesion
  • brachial plexus lesions
- elite association - COSMIC cancer census association via MalaCards
Search SUGP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SUGP1

Genetic Association Database (GAD)
SUGP1
Human Genome Epidemiology (HuGE) Navigator
SUGP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUGP1
genes like me logo Genes that share disorders with SUGP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUGP1 Gene

Publications for SUGP1 Gene

  1. SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. (PMID: 12594045) Sampson N.D. … Hewitt J.E. (Gene 2003) 2 3 4 23 67
  2. Genome-wide analysis of hepatic lipid content in extreme obesity. (PMID: 25246029) DiStefano J.K. … Gerhard G.S. (Acta Diabetol 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for SUGP1 Gene

Sources for SUGP1 Gene

Content