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Aliases for SUGCT Gene

Aliases for SUGCT Gene

  • Succinyl-CoA:Glutarate-CoA Transferase 2 3
  • C7orf10 3 4 6
  • SuccinylCoA:Glutarate-CoA Transferase 3 4
  • Dermal Papilla-Derived Protein 13 3 4
  • Russel-Silver Syndrome Candidate 2 3
  • DERP13 3 4
  • Succinate--Hydroxymethylglutarate CoA-Transferase 3
  • Chromosome 7 Open Reading Frame 10 2
  • Dermal Papilla Derived Protein 13 2
  • EC 2.8.3.13 4
  • ORF19 3

External Ids for SUGCT Gene

Previous Symbols for SUGCT Gene

  • C7orf10

Summaries for SUGCT Gene

Entrez Gene Summary for SUGCT Gene

  • This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

GeneCards Summary for SUGCT Gene

SUGCT (Succinyl-CoA:Glutarate-CoA Transferase) is a Protein Coding gene. Diseases associated with SUGCT include glutaric acidemia type 3. An important paralog of this gene is AMACR.

UniProtKB/Swiss-Prot for SUGCT Gene

  • Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUGCT Gene

Genomics for SUGCT Gene

Genomic Location for SUGCT Gene

Start:
40,134,887 bp from pter
End:
40,860,767 bp from pter
Size:
725,881 bases
Orientation:
Plus strand

Genomic View for SUGCT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUGCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUGCT Gene

No data available for Regulatory Elements for SUGCT Gene

Proteins for SUGCT Gene

  • Protein details for SUGCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAC7-SUCHY_HUMAN
    Recommended name:
    Succinate--hydroxymethylglutarate CoA-transferase
    Protein Accession:
    Q9HAC7
    Secondary Accessions:
    • A4D1W5
    • B4DR73
    • Q4KMW4
    • Q4KMW8
    • Q4KMZ0
    • Q8TE00
    • Q8TEY1

    Protein attributes for SUGCT Gene

    Size:
    445 amino acids
    Molecular mass:
    48462 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SUGCT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUGCT Gene

Proteomics data for SUGCT Gene at MOPED

Post-translational modifications for SUGCT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SUGCT Gene

Domains for SUGCT Gene

Protein Domains for SUGCT Gene

Graphical View of Domain Structure for InterPro Entry

Q9HAC7

UniProtKB/Swiss-Prot:

SUCHY_HUMAN
Family:
  • Belongs to the CaiB/BaiF CoA-transferase family.:
    • Q9HAC7
genes like me logo Genes that share domains with SUGCT: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SUGCT Gene

Function for SUGCT Gene

Molecular function for SUGCT Gene

UniProtKB/Swiss-Prot CatalyticActivity: Succinyl-CoA + 3-hydroxy-3-methylglutarate = succinate + (S)-3-hydroxy-3-methylglutaryl-CoA.
UniProtKB/Swiss-Prot Function: Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate.

Enzyme Numbers (IUBMB) for SUGCT Gene

Gene Ontology (GO) - Molecular Function for SUGCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0047369 succinate-hydroxymethylglutarate CoA-transferase activity IDA 23893049
genes like me logo Genes that share ontologies with SUGCT: view

Phenotypes for SUGCT Gene

GenomeRNAi human phenotypes for SUGCT:
genes like me logo Genes that share phenotypes with SUGCT: view

miRNA for SUGCT Gene

miRTarBase miRNAs that target SUGCT

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SUGCT Gene

Localization for SUGCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUGCT Gene

Mitochondrion.

Gene Ontology (GO) - Cellular Components for SUGCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 23893049
genes like me logo Genes that share ontologies with SUGCT: view

No data available for Subcellular locations from COMPARTMENTS for SUGCT Gene

Pathways for SUGCT Gene

SuperPathways for SUGCT Gene

No Data Available

Interacting Proteins for SUGCT Gene

Gene Ontology (GO) - Biological Process for SUGCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with SUGCT: view

No data available for Pathways by source for SUGCT Gene

Transcripts for SUGCT Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SUGCT Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2:

Relevant External Links for SUGCT Gene

GeneLoc Exon Structure for
SUGCT
ECgene alternative splicing isoforms for
SUGCT

Expression for SUGCT Gene

mRNA expression in normal human tissues for SUGCT Gene

mRNA differential expression in normal tissues according to GTEx for SUGCT Gene

This gene is overexpressed in Adrenal Gland (6.8), Artery - Aorta (5.5), and Artery - Coronary (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SUGCT Gene

mRNA Expression by UniProt/SwissProt for SUGCT Gene

Q9HAC7-SUCHY_HUMAN
Tissue specificity: Highly expressed in kidney. Intermediate expression in liver, skeletal muscle and pancreas. Little to no expression detected in other tissues examined.
genes like me logo Genes that share expressions with SUGCT: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SUGCT Gene

Orthologs for SUGCT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUGCT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C7H7orf10 35
  • 99.55 (n)
  • 99.55 (a)
C7ORF10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C4H7orf10 35
  • 90.56 (n)
  • 91.32 (a)
SUGCT 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C18H7orf10 35
  • 90.34 (n)
  • 89.43 (a)
SUGCT 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 5033411D12Rik 16
5033411D12Rik 36
  • 83 (a)
OneToOne
Sugct 35
  • 85.07 (n)
  • 85.45 (a)
oppossum
(Monodelphis domestica)
Mammalia SUGCT 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUGCT 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1308114 35
  • 85.25 (n)
  • 85.48 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 75 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
C7ORF10 35
  • 74.22 (n)
  • 75.9 (a)
lizard
(Anolis carolinensis)
Reptilia SUGCT 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490876 35
  • 72.04 (n)
  • 73.95 (a)
zebrafish
(Danio rerio)
Actinopterygii SUGCT (1 of 2) 36
  • 62 (a)
OneToMany
SUGCT (2 of 2) 36
  • 72 (a)
OneToMany
zgc:113390 35
  • 70.42 (n)
  • 76.53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012657 35
  • 55.74 (n)
  • 57.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10877 35
  • 52.76 (n)
  • 48.24 (a)
CG10877 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK892.4 36
  • 24 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07298 35
  • 52.93 (n)
  • 52.16 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11829 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToOne
Species with no ortholog for SUGCT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUGCT Gene

ENSEMBL:
Gene Tree for SUGCT (if available)
TreeFam:
Gene Tree for SUGCT (if available)

Paralogs for SUGCT Gene

Paralogs for SUGCT Gene

Selected SIMAP similar genes for SUGCT Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SUGCT: view

Variants for SUGCT Gene

Sequence variations from dbSNP and Humsavar for SUGCT Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs372494 -- 40,138,063(-) cctga(A/C)ttcac intron-variant
rs376537 -- 40,157,322(+) CGGCA(C/G)GTGGG intron-variant
rs388354 -- 40,150,850(+) gtgaa(A/C)ccctt intron-variant
rs419576 -- 40,157,569(+) TAAAA(C/T)ACTTC intron-variant
rs434459 -- 40,148,101(+) ttggc(A/G)ggaaa intron-variant

Relevant External Links for SUGCT Gene

HapMap Linkage Disequilibrium report
SUGCT
Human Gene Mutation Database (HGMD)
SUGCT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SUGCT Gene

Disorders for SUGCT Gene

(1) OMIM Diseases for SUGCT Gene (609187)

UniProtKB/Swiss-Prot

SUCHY_HUMAN
  • Glutaric aciduria 3 (GA3) [MIM:231690]: A metabolic disorder due to peroxisomal glutaryl-CoA oxidase deficiency and characterized by the excretion of abnormal quantities of glutaric acid but low 3-hydroxyglutaric acid. {ECO:0000269 PubMed:18926513}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) MalaCards Diseases for SUGCT Gene

Search for SUGCT Gene in MalaCards »
genes like me logo Genes that share disorders with SUGCT: view

Publications for SUGCT Gene

  1. Molecular genetic studies of human chromosome 7 in Russell-Silver syndrome. (PMID: 11829489) Nakabayashi K. … Scherer S.W. (Genomics 2002) 2 3 4
  2. C7orf10 encodes succinate-hydroxymethylglutarate CoA-transferase, the enzyme that converts glutarate to glutaryl-CoA. (PMID: 23893049) Marlaire S. … Veiga-da-Cunha M. (J. Inherit. Metab. Dis. 2014) 2 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SUGCT Gene

Sources for SUGCT Gene

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