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Aliases for SUGCT Gene

Aliases for SUGCT Gene

  • Succinyl-CoA:Glutarate-CoA Transferase 2 3
  • C7orf10 3 4 6
  • SuccinylCoA:Glutarate-CoA Transferase 3 4
  • Dermal Papilla-Derived Protein 13 3 4
  • Russel-Silver Syndrome Candidate 2 3
  • DERP13 3 4
  • Succinate--Hydroxymethylglutarate CoA-Transferase 3
  • Chromosome 7 Open Reading Frame 10 2
  • Dermal Papilla Derived Protein 13 2
  • EC 4
  • ORF19 3

External Ids for SUGCT Gene

Previous HGNC Symbols for SUGCT Gene

  • C7orf10

Previous GeneCards Identifiers for SUGCT Gene

  • GC07P040182

Summaries for SUGCT Gene

Entrez Gene Summary for SUGCT Gene

  • This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

GeneCards Summary for SUGCT Gene

SUGCT (Succinyl-CoA:Glutarate-CoA Transferase) is a Protein Coding gene. Diseases associated with SUGCT include glutaric acidemia type 3. An important paralog of this gene is AMACR.

UniProtKB/Swiss-Prot for SUGCT Gene

  • Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUGCT Gene

Genomics for SUGCT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SUGCT Gene

40,134,887 bp from pter
40,860,767 bp from pter
725,881 bases
Plus strand

Genomic View for SUGCT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUGCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUGCT Gene

No data available for Regulatory Elements for SUGCT Gene

Proteins for SUGCT Gene

  • Protein details for SUGCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Succinate--hydroxymethylglutarate CoA-transferase
    Protein Accession:
    Secondary Accessions:
    • A4D1W5
    • B4DR73
    • Q4KMW4
    • Q4KMW8
    • Q4KMZ0
    • Q8TE00
    • Q8TEY1

    Protein attributes for SUGCT Gene

    445 amino acids
    Molecular mass:
    48462 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SUGCT Gene


neXtProt entry for SUGCT Gene

Proteomics data for SUGCT Gene at MOPED

Post-translational modifications for SUGCT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SUGCT Gene

Domains for SUGCT Gene

Protein Domains for SUGCT Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9HAC7
  • Belongs to the CaiB/BaiF CoA-transferase family.
genes like me logo Genes that share domains with SUGCT: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SUGCT Gene

Function for SUGCT Gene

Molecular function for SUGCT Gene

UniProtKB/Swiss-Prot CatalyticActivity: Succinyl-CoA + 3-hydroxy-3-methylglutarate = succinate + (S)-3-hydroxy-3-methylglutaryl-CoA.
UniProtKB/Swiss-Prot Function: Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate.

Enzyme Numbers (IUBMB) for SUGCT Gene

Gene Ontology (GO) - Molecular Function for SUGCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0047369 succinate-hydroxymethylglutarate CoA-transferase activity IDA 23893049
genes like me logo Genes that share ontologies with SUGCT: view

Phenotypes for SUGCT Gene

GenomeRNAi human phenotypes for SUGCT:
genes like me logo Genes that share phenotypes with SUGCT: view

miRNA for SUGCT Gene

miRTarBase miRNAs that target SUGCT

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SUGCT Gene

Localization for SUGCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUGCT Gene


Gene Ontology (GO) - Cellular Components for SUGCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 23893049
genes like me logo Genes that share ontologies with SUGCT: view

No data available for Subcellular locations from COMPARTMENTS for SUGCT Gene

Pathways for SUGCT Gene

SuperPathways for SUGCT Gene

No Data Available

Interacting Proteins for SUGCT Gene

Gene Ontology (GO) - Biological Process for SUGCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with SUGCT: view

No data available for Pathways by source for SUGCT Gene

Transcripts for SUGCT Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUGCT

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SUGCT
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUGCT Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -

Relevant External Links for SUGCT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SUGCT Gene

mRNA expression in normal human tissues for SUGCT Gene

mRNA differential expression in normal tissues according to GTEx for SUGCT Gene

This gene is overexpressed in Adrenal Gland (6.8), Artery - Aorta (5.5), and Artery - Coronary (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SUGCT Gene

mRNA Expression by UniProt/SwissProt for SUGCT Gene

Tissue specificity: Highly expressed in kidney. Intermediate expression in liver, skeletal muscle and pancreas. Little to no expression detected in other tissues examined.
genes like me logo Genes that share expressions with SUGCT: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SUGCT Gene

Orthologs for SUGCT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUGCT Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C7H7orf10 35
  • 99.55 (n)
  • 99.55 (a)
C7ORF10 36
  • 100 (a)
(Bos Taurus)
Mammalia C4H7orf10 35
  • 90.56 (n)
  • 91.32 (a)
  • 91 (a)
(Canis familiaris)
Mammalia C18H7orf10 35
  • 90.34 (n)
  • 89.43 (a)
  • 81 (a)
(Mus musculus)
Mammalia 5033411D12Rik 16
5033411D12Rik 36
  • 83 (a)
Sugct 35
  • 85.07 (n)
  • 85.45 (a)
(Monodelphis domestica)
Mammalia SUGCT 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia SUGCT 36
  • 85 (a)
(Rattus norvegicus)
Mammalia RGD1308114 35
  • 85.25 (n)
  • 85.48 (a)
(Gallus gallus)
Aves -- 36
  • 75 (a)
-- 36
  • 76 (a)
C7ORF10 35
  • 74.22 (n)
  • 75.9 (a)
(Anolis carolinensis)
Reptilia SUGCT 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490876 35
  • 72.04 (n)
  • 73.95 (a)
(Danio rerio)
Actinopterygii SUGCT (1 of 2) 36
  • 62 (a)
SUGCT (2 of 2) 36
  • 72 (a)
zgc:113390 35
  • 70.42 (n)
  • 76.53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012657 35
  • 55.74 (n)
  • 57.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10877 35
  • 52.76 (n)
  • 48.24 (a)
CG10877 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea ZK892.4 36
  • 24 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07298 35
  • 52.93 (n)
  • 52.16 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11829 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
Species with no ortholog for SUGCT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUGCT Gene

Gene Tree for SUGCT (if available)
Gene Tree for SUGCT (if available)

Paralogs for SUGCT Gene

Paralogs for SUGCT Gene

Selected SIMAP similar genes for SUGCT Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SUGCT: view

Variants for SUGCT Gene

Sequence variations from dbSNP and Humsavar for SUGCT Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs372494 -- 40,138,063(-) cctga(A/C)ttcac intron-variant
rs376537 -- 40,157,322(+) CGGCA(C/G)GTGGG intron-variant
rs388354 -- 40,150,850(+) gtgaa(A/C)ccctt intron-variant
rs419576 -- 40,157,569(+) TAAAA(C/T)ACTTC intron-variant
rs434459 -- 40,148,101(+) ttggc(A/G)ggaaa intron-variant

Relevant External Links for SUGCT Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SUGCT Gene

Disorders for SUGCT Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SUGCT Gene including...

Search for SUGCT Gene in MalaCards »

(1) OMIM Diseases for SUGCT Gene (609187)


  • Glutaric aciduria 3 (GA3) [MIM:231690]: A metabolic disorder due to peroxisomal glutaryl-CoA oxidase deficiency and characterized by the excretion of abnormal quantities of glutaric acid but low 3-hydroxyglutaric acid. {ECO:0000269 PubMed:18926513}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with SUGCT: view

Publications for SUGCT Gene

  1. Molecular genetic studies of human chromosome 7 in Russell-Silver syndrome. (PMID: 11829489) Nakabayashi K. … Scherer S.W. (Genomics 2002) 2 3 4
  2. C7orf10 encodes succinate-hydroxymethylglutarate CoA-transferase, the enzyme that converts glutarate to glutaryl-CoA. (PMID: 23893049) Marlaire S. … Veiga-da-Cunha M. (J. Inherit. Metab. Dis. 2014) 2 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SUGCT Gene

Sources for SUGCT Gene

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