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Aliases for SUGCT Gene

Aliases for SUGCT Gene

  • Succinyl-CoA:Glutarate-CoA Transferase 2 3 5
  • SuccinylCoA:Glutarate-CoA Transferase 3 4
  • Dermal Papilla-Derived Protein 13 3 4
  • Russel-Silver Syndrome Candidate 2 3
  • C7orf10 3 4
  • DERP13 3 4
  • Chromosome 7 Open Reading Frame 10 2
  • Dermal Papilla Derived Protein 13 2
  • EC 4
  • ORF19 3
  • GA3 3

External Ids for SUGCT Gene

Previous HGNC Symbols for SUGCT Gene

  • C7orf10

Previous GeneCards Identifiers for SUGCT Gene

  • GC07P040182

Summaries for SUGCT Gene

Entrez Gene Summary for SUGCT Gene

  • This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

GeneCards Summary for SUGCT Gene

SUGCT (Succinyl-CoA:Glutarate-CoA Transferase) is a Protein Coding gene. Diseases associated with SUGCT include Glutaric Aciduria Iii and Glutaric Acidemia Type Iii. GO annotations related to this gene include succinate-hydroxymethylglutarate CoA-transferase activity. An important paralog of this gene is AMACR.

UniProtKB/Swiss-Prot for SUGCT Gene

  • Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUGCT Gene

Genomics for SUGCT Gene

Regulatory Elements for SUGCT Gene

Enhancers for SUGCT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SUGCT on UCSC Golden Path with GeneCards custom track

Promoters for SUGCT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUGCT on UCSC Golden Path with GeneCards custom track

Genomic Location for SUGCT Gene

40,134,965 bp from pter
40,860,767 bp from pter
725,803 bases
Plus strand

Genomic View for SUGCT Gene

Genes around SUGCT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUGCT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUGCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUGCT Gene

Proteins for SUGCT Gene

  • Protein details for SUGCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Succinate--hydroxymethylglutarate CoA-transferase
    Protein Accession:
    Secondary Accessions:
    • A4D1W5
    • B4DR73
    • Q4KMW4
    • Q4KMW8
    • Q4KMZ0
    • Q8TE00
    • Q8TEY1

    Protein attributes for SUGCT Gene

    445 amino acids
    Molecular mass:
    48462 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SUGCT Gene


neXtProt entry for SUGCT Gene

Proteomics data for SUGCT Gene at MOPED

Post-translational modifications for SUGCT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SUGCT Gene

Domains & Families for SUGCT Gene

Protein Domains for SUGCT Gene

Suggested Antigen Peptide Sequences for SUGCT Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CaiB/BaiF CoA-transferase family.
  • Belongs to the CaiB/BaiF CoA-transferase family.
genes like me logo Genes that share domains with SUGCT: view

No data available for Gene Families for SUGCT Gene

Function for SUGCT Gene

Molecular function for SUGCT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Succinyl-CoA + 3-hydroxy-3-methylglutarate = succinate + (S)-3-hydroxy-3-methylglutaryl-CoA.
UniProtKB/Swiss-Prot Function:
Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate.

Enzyme Numbers (IUBMB) for SUGCT Gene

Phenotypes for SUGCT Gene

genes like me logo Genes that share phenotypes with SUGCT: view

Human Phenotype Ontology for SUGCT Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for SUGCT Gene

miRTarBase miRNAs that target SUGCT

No data available for Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for SUGCT Gene

Localization for SUGCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUGCT Gene


No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SUGCT Gene

Pathways & Interactions for SUGCT Gene

SuperPathways for SUGCT Gene

No Data Available

Interacting Proteins for SUGCT Gene

Gene Ontology (GO) - Biological Process for SUGCT Gene


No data available for Pathways by source and SIGNOR curated interactions for SUGCT Gene

Drugs & Compounds for SUGCT Gene

No Compound Related Data Available

Transcripts for SUGCT Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SUGCT Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -

Relevant External Links for SUGCT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SUGCT Gene

mRNA expression in normal human tissues for SUGCT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUGCT Gene

This gene is overexpressed in Adrenal Gland (x6.8), Artery - Aorta (x5.5), and Artery - Coronary (x4.2).

Protein differential expression in normal tissues from HIPED for SUGCT Gene

This gene is overexpressed in Kidney (32.8), Gallbladder (9.6), and Liver (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SUGCT Gene

mRNA Expression by UniProt/SwissProt for SUGCT Gene

Tissue specificity: Highly expressed in kidney. Intermediate expression in liver, skeletal muscle and pancreas. Little to no expression detected in other tissues examined.
genes like me logo Genes that share expression patterns with SUGCT: view

Protein tissue co-expression partners for SUGCT Gene

Primer Products

Orthologs for SUGCT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUGCT Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C4H7orf10 35
  • 90.56 (n)
  • 91.32 (a)
  • 91 (a)
(Canis familiaris)
Mammalia C18H7orf10 35
  • 90.34 (n)
  • 89.43 (a)
  • 81 (a)
(Mus musculus)
Mammalia Sugct 35
  • 85.07 (n)
  • 85.45 (a)
Sugct 16
5033411D12Rik 36
  • 83 (a)
(Pan troglodytes)
Mammalia C7H7orf10 35
  • 99.55 (n)
  • 99.55 (a)
C7ORF10 36
  • 100 (a)
(Rattus norvegicus)
Mammalia RGD1308114 35
  • 85.25 (n)
  • 85.48 (a)
(Monodelphis domestica)
Mammalia SUGCT 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia SUGCT 36
  • 85 (a)
(Gallus gallus)
Aves C7ORF10 35
  • 74.22 (n)
  • 75.9 (a)
-- 36
  • 75 (a)
-- 36
  • 76 (a)
(Anolis carolinensis)
Reptilia SUGCT 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490876 35
  • 72.04 (n)
  • 73.95 (a)
(Danio rerio)
Actinopterygii zgc:113390 35
  • 70.42 (n)
  • 76.53 (a)
SUGCT (1 of 2) 36
  • 62 (a)
SUGCT (2 of 2) 36
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012657 35
  • 55.74 (n)
  • 57.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10877 35
  • 52.76 (n)
  • 48.24 (a)
CG10877 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea ZK892.4 36
  • 24 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11829 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07298 35
  • 52.93 (n)
  • 52.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
Species with no ortholog for SUGCT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUGCT Gene

Gene Tree for SUGCT (if available)
Gene Tree for SUGCT (if available)

Paralogs for SUGCT Gene

Paralogs for SUGCT Gene

(6) SIMAP similar genes for SUGCT Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SUGCT: view

Variants for SUGCT Gene

Sequence variations from dbSNP and Humsavar for SUGCT Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs137852860 Glutaric aciduria 3 (GA3) 40,459,197(+) CTGAA(C/T)GGTAA reference, missense
rs766317 -- 40,757,137(+) GTGGG(A/G)TAGTA intron-variant
rs886765 -- 40,644,253(+) ACACC(C/T)TGTCT intron-variant
rs886831 -- 40,808,804(+) TTCCA(C/G)AGTTA intron-variant
rs887445 -- 40,175,985(+) ccagc(A/T)ctgtg intron-variant

Variation tolerance for SUGCT Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUGCT Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SUGCT Gene

Disorders for SUGCT Gene

MalaCards: The human disease database

(6) MalaCards diseases for SUGCT Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, and DISEASES

Disorder Aliases PubMed IDs
glutaric aciduria iii
  • ga iii
glutaric acidemia type iii
  • glutaric aciduria iii
amyotrophic lateral sclerosis type 4
  • amyotrophic lateral sclerosis 4, juvenile
amyotrophic lateral sclerosis 3
  • amyotrophic lateral sclerosis type 3
opportunistic mycosis
  • opportunistic mycoses
- elite association - COSMIC cancer census association via MalaCards
Search SUGCT in MalaCards View complete list of genes associated with diseases


  • Glutaric aciduria 3 (GA3) [MIM:231690]: A metabolic disorder due to peroxisomal glutaryl-CoA oxidase deficiency and characterized by the excretion of abnormal quantities of glutaric acid but low 3-hydroxyglutaric acid. {ECO:0000269 PubMed:18926513}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SUGCT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SUGCT: view

No data available for Genatlas for SUGCT Gene

Publications for SUGCT Gene

  1. C7orf10 encodes succinate-hydroxymethylglutarate CoA-transferase, the enzyme that converts glutarate to glutaryl-CoA. (PMID: 23893049) Marlaire S. … Veiga-da-Cunha M. (J. Inherit. Metab. Dis. 2014) 2 3 4 67
  2. Molecular genetic studies of human chromosome 7 in Russell-Silver syndrome. (PMID: 11829489) Nakabayashi K. … Scherer S.W. (Genomics 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PMID: 23793025) Anttila V. … . (Nat. Genet. 2013) 3
  5. Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing. (PMID: 22277967) Calvo S.E. … Mootha V.K. (Sci. Transl. Med. 2012) 3

Products for SUGCT Gene

Sources for SUGCT Gene