Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SUGCT Gene

Aliases for SUGCT Gene

  • Succinyl-CoA:Glutarate-CoA Transferase 2 3 5
  • SuccinylCoA:Glutarate-CoA Transferase 3 4
  • Dermal Papilla-Derived Protein 13 3 4
  • Russel-Silver Syndrome Candidate 2 3
  • C7orf10 3 4
  • DERP13 3 4
  • Succinate--Hydroxymethylglutarate CoA-Transferase 3
  • Chromosome 7 Open Reading Frame 10 2
  • Dermal Papilla Derived Protein 13 2
  • EC 2.8.3.13 4
  • ORF19 3
  • GA3 3

External Ids for SUGCT Gene

Previous HGNC Symbols for SUGCT Gene

  • C7orf10

Previous GeneCards Identifiers for SUGCT Gene

  • GC07P040182

Summaries for SUGCT Gene

Entrez Gene Summary for SUGCT Gene

  • This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

GeneCards Summary for SUGCT Gene

SUGCT (Succinyl-CoA:Glutarate-CoA Transferase) is a Protein Coding gene. Diseases associated with SUGCT include Glutaric Aciduria Iii and Amyotrophic Lateral Sclerosis Type 4. GO annotations related to this gene include succinate-hydroxymethylglutarate CoA-transferase activity. An important paralog of this gene is AMACR.

UniProtKB/Swiss-Prot for SUGCT Gene

  • Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUGCT Gene

Genomics for SUGCT Gene

Regulatory Elements for SUGCT Gene

Enhancers for SUGCT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SUGCT on UCSC Golden Path with GeneCards custom track

Promoters for SUGCT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SUGCT Gene

Chromosome:
7
Start:
40,134,965 bp from pter
End:
40,860,767 bp from pter
Size:
725,803 bases
Orientation:
Plus strand

Genomic View for SUGCT Gene

Genes around SUGCT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUGCT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUGCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUGCT Gene

Proteins for SUGCT Gene

  • Protein details for SUGCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAC7-SUCHY_HUMAN
    Recommended name:
    Succinate--hydroxymethylglutarate CoA-transferase
    Protein Accession:
    Q9HAC7
    Secondary Accessions:
    • A4D1W5
    • B4DR73
    • Q4KMW4
    • Q4KMW8
    • Q4KMZ0
    • Q8TE00
    • Q8TEY1

    Protein attributes for SUGCT Gene

    Size:
    445 amino acids
    Molecular mass:
    48462 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SUGCT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUGCT Gene

Post-translational modifications for SUGCT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SUGCT Gene

Domains & Families for SUGCT Gene

Protein Domains for SUGCT Gene

Suggested Antigen Peptide Sequences for SUGCT Gene

Graphical View of Domain Structure for InterPro Entry

Q9HAC7

UniProtKB/Swiss-Prot:

SUCHY_HUMAN :
  • Belongs to the CaiB/BaiF CoA-transferase family.
Family:
  • Belongs to the CaiB/BaiF CoA-transferase family.
genes like me logo Genes that share domains with SUGCT: view

No data available for Gene Families for SUGCT Gene

Function for SUGCT Gene

Molecular function for SUGCT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Succinyl-CoA + 3-hydroxy-3-methylglutarate = succinate + (S)-3-hydroxy-3-methylglutaryl-CoA.
UniProtKB/Swiss-Prot Function:
Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate.

Enzyme Numbers (IUBMB) for SUGCT Gene

Gene Ontology (GO) - Molecular Function for SUGCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047369 succinate-hydroxymethylglutarate CoA-transferase activity IDA 23893049
genes like me logo Genes that share ontologies with SUGCT: view

Phenotypes for SUGCT Gene

genes like me logo Genes that share phenotypes with SUGCT: view

Human Phenotype Ontology for SUGCT Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for SUGCT Gene

miRTarBase miRNAs that target SUGCT

Clone Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SUGCT Gene

Localization for SUGCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUGCT Gene

Mitochondrion.

Gene Ontology (GO) - Cellular Components for SUGCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 23893049
genes like me logo Genes that share ontologies with SUGCT: view

No data available for Subcellular locations from COMPARTMENTS for SUGCT Gene

Pathways & Interactions for SUGCT Gene

SuperPathways for SUGCT Gene

No Data Available

Interacting Proteins for SUGCT Gene

Selected Interacting proteins: Q9HAC7-SUCHY_HUMAN for SUGCT Gene via IID

Gene Ontology (GO) - Biological Process for SUGCT Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SUGCT Gene

Drugs & Compounds for SUGCT Gene

No Compound Related Data Available

Transcripts for SUGCT Gene

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUGCT Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2:

Relevant External Links for SUGCT Gene

GeneLoc Exon Structure for
SUGCT
ECgene alternative splicing isoforms for
SUGCT

Expression for SUGCT Gene

mRNA expression in normal human tissues for SUGCT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUGCT Gene

This gene is overexpressed in Adrenal Gland (x6.8), Artery - Aorta (x5.5), and Artery - Coronary (x4.2).

Protein differential expression in normal tissues from HIPED for SUGCT Gene

This gene is overexpressed in Kidney (32.8), Gallbladder (9.6), and Liver (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SUGCT Gene



Protein tissue co-expression partners for SUGCT Gene

NURSA nuclear receptor signaling pathways regulating expression of SUGCT Gene:

SUGCT

mRNA Expression by UniProt/SwissProt for SUGCT Gene:

Q9HAC7-SUCHY_HUMAN
Tissue specificity: Highly expressed in kidney. Intermediate expression in liver, skeletal muscle and pancreas. Little to no expression detected in other tissues examined.
genes like me logo Genes that share expression patterns with SUGCT: view

Primer Products

Orthologs for SUGCT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUGCT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C4H7orf10 34
  • 90.56 (n)
  • 91.32 (a)
SUGCT 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C18H7orf10 34
  • 90.34 (n)
  • 89.43 (a)
SUGCT 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sugct 34
  • 85.07 (n)
  • 85.45 (a)
Sugct 16
5033411D12Rik 35
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C7H7orf10 34
  • 99.55 (n)
  • 99.55 (a)
C7ORF10 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1308114 34
  • 85.25 (n)
  • 85.48 (a)
oppossum
(Monodelphis domestica)
Mammalia SUGCT 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUGCT 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves C7ORF10 34
  • 74.22 (n)
  • 75.9 (a)
-- 35
  • 75 (a)
OneToMany
-- 35
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SUGCT 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490876 34
  • 72.04 (n)
  • 73.95 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:113390 34
  • 70.42 (n)
  • 76.53 (a)
SUGCT (1 of 2) 35
  • 62 (a)
OneToMany
SUGCT (2 of 2) 35
  • 72 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012657 34
  • 55.74 (n)
  • 57.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10877 34
  • 52.76 (n)
  • 48.24 (a)
CG10877 35
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK892.4 35
  • 24 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11829 34
bread mold
(Neurospora crassa)
Ascomycetes NCU07298 34
  • 52.93 (n)
  • 52.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
OneToOne
Species where no ortholog for SUGCT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUGCT Gene

ENSEMBL:
Gene Tree for SUGCT (if available)
TreeFam:
Gene Tree for SUGCT (if available)

Paralogs for SUGCT Gene

Paralogs for SUGCT Gene

(6) SIMAP similar genes for SUGCT Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SUGCT: view

Variants for SUGCT Gene

Sequence variations from dbSNP and Humsavar for SUGCT Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs137852860 Glutaric aciduria 3 (GA3) 40,459,197(+) CTGAA(C/T)GGTAA reference, missense
rs2108189 -- 40,629,256(+) TGCTG(A/C)TCTTC intron-variant
rs2108375 -- 40,811,454(+) tgttt(C/T)atagt intron-variant
rs2108376 -- 40,811,567(+) CTCAG(C/T)TTGAA intron-variant
rs2108377 -- 40,839,297(+) GAGTG(C/T)ACTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUGCT Gene

Variant ID Type Subtype PubMed ID
dgv11290n54 CNV gain 21841781
dgv11291n54 CNV loss 21841781
dgv6338n100 CNV gain 25217958
dgv6339n100 CNV loss 25217958
esv1003835 CNV insertion 20482838
esv1735710 CNV insertion 17803354
esv2581938 OTHER inversion 19546169
esv2663953 CNV deletion 23128226
esv2734304 CNV deletion 23290073
esv2734305 CNV deletion 23290073
esv2734307 CNV deletion 23290073
esv2734308 CNV deletion 23290073
esv2759525 CNV gain 17122850
esv2759526 CNV gain 17122850
esv2761115 CNV gain 21179565
esv2761320 CNV loss 21179565
esv3331018 OTHER inversion 20981092
esv3335087 OTHER inversion 20981092
esv34484 CNV gain 17911159
esv34547 CNV gain 17911159
esv3541536 CNV deletion 23714750
esv3571805 CNV loss 25503493
esv3576353 CNV gain 25503493
esv3576354 CNV gain 25503493
esv3612920 CNV gain 21293372
esv3612922 CNV gain 21293372
esv3612923 CNV gain 21293372
esv3612924 CNV loss 21293372
esv3612925 CNV loss 21293372
esv3612926 CNV loss 21293372
esv3612927 CNV loss 21293372
esv3612928 CNV loss 21293372
esv3612929 CNV loss 21293372
esv3612931 CNV loss 21293372
esv3612932 CNV gain 21293372
esv3612933 CNV loss 21293372
esv3612935 OTHER inversion 21293372
esv3891100 CNV loss 25118596
esv3891101 CNV loss 25118596
esv3891102 CNV loss 25118596
esv7091 OTHER inversion 19470904
nsv1015701 CNV gain 25217958
nsv1016800 CNV loss 25217958
nsv1017909 CNV loss 25217958
nsv1019032 CNV gain 25217958
nsv1024735 CNV gain 25217958
nsv1029342 CNV loss 25217958
nsv1032278 CNV gain 25217958
nsv1068322 OTHER inversion 25765185
nsv1109858 CNV deletion 24896259
nsv1116416 CNV insertion 24896259
nsv1117708 CNV deletion 24896259
nsv1124190 CNV deletion 24896259
nsv1129781 CNV tandem duplication 24896259
nsv1132959 CNV insertion 24896259
nsv435962 OTHER inversion 17901297
nsv464437 CNV gain 19166990
nsv475944 CNV novel sequence insertion 20440878
nsv477479 CNV novel sequence insertion 20440878
nsv509194 CNV insertion 20534489
nsv513673 OTHER inversion 21212237
nsv513674 OTHER inversion 21212237
nsv520374 CNV loss 19592680
nsv520748 CNV loss 19592680
nsv5711 CNV deletion 18451855
nsv5712 CNV insertion 18451855
nsv5713 CNV insertion 18451855
nsv606709 CNV gain 21841781
nsv7394 OTHER inversion 18451855
nsv8081 CNV gain 18304495
nsv824080 CNV gain 20364138
nsv824081 CNV loss 20364138
nsv830969 CNV gain 17160897
nsv830971 CNV gain+loss 17160897
nsv830972 CNV loss 17160897
nsv830973 CNV loss 17160897
nsv966785 CNV duplication 23825009
nsv971193 CNV duplication 23825009

Variation tolerance for SUGCT Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUGCT Gene

Human Gene Mutation Database (HGMD)
SUGCT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUGCT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUGCT Gene

Disorders for SUGCT Gene

MalaCards: The human disease database

(5) MalaCards diseases for SUGCT Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, and DISEASES

Disorder Aliases PubMed IDs
glutaric aciduria iii
  • ga iii
amyotrophic lateral sclerosis type 4
  • amyotrophic lateral sclerosis 4, juvenile
amyotrophic lateral sclerosis 3
  • amyotrophic lateral sclerosis type 3
opportunistic mycosis
  • opportunistic mycoses
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search SUGCT in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SUCHY_HUMAN
  • Glutaric aciduria 3 (GA3) [MIM:231690]: A metabolic disorder due to peroxisomal glutaryl-CoA oxidase deficiency and characterized by the excretion of abnormal quantities of glutaric acid but low 3-hydroxyglutaric acid. {ECO:0000269 PubMed:18926513}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SUGCT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUGCT
genes like me logo Genes that share disorders with SUGCT: view

No data available for Genatlas for SUGCT Gene

Publications for SUGCT Gene

  1. C7orf10 encodes succinate-hydroxymethylglutarate CoA-transferase, the enzyme that converts glutarate to glutaryl-CoA. (PMID: 23893049) Marlaire S. … Veiga-da-Cunha M. (J. Inherit. Metab. Dis. 2014) 2 3 4 65
  2. Molecular genetic studies of human chromosome 7 in Russell-Silver syndrome. (PMID: 11829489) Nakabayashi K. … Scherer S.W. (Genomics 2002) 2 3 4 65
  3. Genetic mapping of glutaric aciduria, type 3, to chromosome 7 and identification of mutations in C7orf10. (PMID: 18926513) Sherman E.A. … Puffenberger E.G. (Am. J. Hum. Genet. 2008) 3 4 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for SUGCT Gene

Sources for SUGCT Gene

Content
Loading form....