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Aliases for SUGCT Gene

Aliases for SUGCT Gene

  • Succinyl-CoA:Glutarate-CoA Transferase 2 3 5
  • SuccinylCoA:Glutarate-CoA Transferase 3 4
  • Dermal Papilla-Derived Protein 13 3 4
  • Russel-Silver Syndrome Candidate 2 3
  • C7orf10 3 4
  • DERP13 3 4
  • Succinate--Hydroxymethylglutarate CoA-Transferase 3
  • Chromosome 7 Open Reading Frame 10 2
  • Dermal Papilla Derived Protein 13 2
  • EC 4
  • ORF19 3
  • GA3 3

External Ids for SUGCT Gene

Previous HGNC Symbols for SUGCT Gene

  • C7orf10

Previous GeneCards Identifiers for SUGCT Gene

  • GC07P040182

Summaries for SUGCT Gene

Entrez Gene Summary for SUGCT Gene

  • This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

GeneCards Summary for SUGCT Gene

SUGCT (Succinyl-CoA:Glutarate-CoA Transferase) is a Protein Coding gene. Diseases associated with SUGCT include Glutaric Aciduria Iii and Glutaric Acidemia Type Iii. Gene Ontology (GO) annotations related to this gene include succinate-hydroxymethylglutarate CoA-transferase activity. An important paralog of this gene is AMACR.

UniProtKB/Swiss-Prot for SUGCT Gene

  • Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate.

Additional gene information for SUGCT Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUGCT Gene

Genomics for SUGCT Gene

GeneHancer (GH) Regulatory Elements for SUGCT Gene

Promoters and enhancers for SUGCT Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I040132 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.6 -571 2.8 PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 IRF4 MPLKIP GC07P040132 SUGCT CDK13 CICP22 ENSG00000228554 ENSG00000259826 LINC00265 LOC100101126 YAE1D1
GH07I040219 Enhancer 1 Ensembl ENCODE dbSUPER 5.5 +86.6 86615 5.3 FOXA2 ZSCAN4 MAFG REST NR2F2 YY1 JUND ZNF366 POLR2A HNF4A SUGCT LINC00265 GC07P040231 THUMPD3P1
GH07I040156 Enhancer 0.3 ENCODE 17.3 +22.3 22296 1.7 IKZF1 SUGCT MPLKIP LINC00265 THUMPD3P1 GC07P040231
GH07I040198 Enhancer 0.7 ENCODE dbSUPER 5.6 +65.4 65441 2.9 CTCF ZNF316 ZNF366 FOS RAD21 SUGCT LINC00265 GC07P040231 THUMPD3P1
GH07I040194 Enhancer 0.5 ENCODE dbSUPER 5.6 +60.6 60582 2.6 FOS SUGCT LINC00265 GC07P040231 THUMPD3P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SUGCT on UCSC Golden Path with GeneCards custom track

Genomic Locations for SUGCT Gene

Genomic Locations for SUGCT Gene
725,803 bases
Plus strand

Genomic View for SUGCT Gene

Genes around SUGCT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUGCT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUGCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUGCT Gene

Proteins for SUGCT Gene

  • Protein details for SUGCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Succinate--hydroxymethylglutarate CoA-transferase
    Protein Accession:
    Secondary Accessions:
    • A4D1W5
    • B4DR73
    • Q4KMW4
    • Q4KMW8
    • Q4KMZ0
    • Q8TE00
    • Q8TEY1

    Protein attributes for SUGCT Gene

    445 amino acids
    Molecular mass:
    48462 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SUGCT Gene


neXtProt entry for SUGCT Gene

Post-translational modifications for SUGCT Gene

No Post-translational modifications

No data available for DME Specific Peptides for SUGCT Gene

Domains & Families for SUGCT Gene

Gene Families for SUGCT Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SUGCT Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CaiB/BaiF CoA-transferase family.
  • Belongs to the CaiB/BaiF CoA-transferase family.
genes like me logo Genes that share domains with SUGCT: view

Function for SUGCT Gene

Molecular function for SUGCT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Succinyl-CoA + 3-hydroxy-3-methylglutarate = succinate + (S)-3-hydroxy-3-methylglutaryl-CoA.
UniProtKB/Swiss-Prot Function:
Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate.

Enzyme Numbers (IUBMB) for SUGCT Gene

Phenotypes From GWAS Catalog for SUGCT Gene

Gene Ontology (GO) - Molecular Function for SUGCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0033608 formyl-CoA transferase activity IEA --
GO:0047369 succinate-hydroxymethylglutarate CoA-transferase activity IDA,IEA 23893049
genes like me logo Genes that share ontologies with SUGCT: view

Phenotypes for SUGCT Gene

genes like me logo Genes that share phenotypes with SUGCT: view

Human Phenotype Ontology for SUGCT Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for SUGCT Gene

miRTarBase miRNAs that target SUGCT

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SUGCT Gene

Localization for SUGCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUGCT Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUGCT gene
Compartment Confidence
mitochondrion 5
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SUGCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 23893049
genes like me logo Genes that share ontologies with SUGCT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SUGCT Gene

Pathways & Interactions for SUGCT Gene

SuperPathways for SUGCT Gene

No Data Available

Interacting Proteins for SUGCT Gene

Selected Interacting proteins: Q9HAC7-SUCHY_HUMAN for SUGCT Gene via IID

Gene Ontology (GO) - Biological Process for SUGCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with SUGCT: view

No data available for Pathways by source and SIGNOR curated interactions for SUGCT Gene

Drugs & Compounds for SUGCT Gene

No Compound Related Data Available

Transcripts for SUGCT Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUGCT Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -

Relevant External Links for SUGCT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SUGCT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUGCT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUGCT Gene

This gene is overexpressed in Adrenal Gland (x6.8), Artery - Aorta (x5.5), and Artery - Coronary (x4.2).

Protein differential expression in normal tissues from HIPED for SUGCT Gene

This gene is overexpressed in Kidney (32.8), Gallbladder (9.6), and Liver (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SUGCT Gene

Protein tissue co-expression partners for SUGCT Gene

NURSA nuclear receptor signaling pathways regulating expression of SUGCT Gene:


mRNA Expression by UniProt/SwissProt for SUGCT Gene:

Tissue specificity: Highly expressed in kidney. Intermediate expression in liver, skeletal muscle and pancreas. Little to no expression detected in other tissues examined.

Evidence on tissue expression from TISSUES for SUGCT Gene

  • Skin(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SUGCT Gene

Germ Layers:
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • nervous
Head and neck:
  • brain
  • ear
  • head
  • esophagus
  • heart
  • intestine
  • large intestine
  • small intestine
  • stomach
  • blood vessel
genes like me logo Genes that share expression patterns with SUGCT: view

Primer Products

Orthologs for SUGCT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUGCT Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C7ORF10 34
  • 100 (a)
C7H7orf10 33
  • 99.55 (n)
(Bos Taurus)
Mammalia SUGCT 34
  • 91 (a)
C4H7orf10 33
  • 90.56 (n)
(Canis familiaris)
Mammalia C18H7orf10 33
  • 90.34 (n)
  • 81 (a)
(Rattus norvegicus)
Mammalia RGD1308114 33
  • 85.25 (n)
(Mus musculus)
Mammalia Sugct 33 16
  • 85.07 (n)
5033411D12Rik 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia SUGCT 34
  • 85 (a)
(Monodelphis domestica)
Mammalia SUGCT 34
  • 72 (a)
(Gallus gallus)
Aves -- 34
  • 76 (a)
-- 34
  • 75 (a)
C7ORF10 33
  • 74.22 (n)
(Anolis carolinensis)
Reptilia SUGCT 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490876 33
  • 72.04 (n)
(Danio rerio)
Actinopterygii SUGCT (2 of 2) 34
  • 72 (a)
zgc:113390 33
  • 70.42 (n)
SUGCT (1 of 2) 34
  • 62 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012657 33
  • 55.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10877 33 34
  • 52.76 (n)
(Caenorhabditis elegans)
Secernentea ZK892.4 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07298 33
  • 52.93 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11829 33
Species where no ortholog for SUGCT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUGCT Gene

Gene Tree for SUGCT (if available)
Gene Tree for SUGCT (if available)

Paralogs for SUGCT Gene

Paralogs for SUGCT Gene

(6) SIMAP similar genes for SUGCT Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SUGCT: view

Variants for SUGCT Gene

Sequence variations from dbSNP and Humsavar for SUGCT Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs137852860 pathogenic, Glutaryl-CoA oxidase deficiency, not provided, Glutaric aciduria 3 (GA3) [MIM:231690] 40,459,197(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs137852861 pathogenic, Glutaryl-CoA oxidase deficiency 40,237,664(+) C/T coding_sequence_variant, stop_gained
rs137852862 pathogenic, Glutaryl-CoA oxidase deficiency 40,188,569(+) C/A/T coding_sequence_variant, stop_gained, synonymous_variant
rs137853117 pathogenic, Trichothiodystrophy, nonphotosensitive 1 40,133,169(+) T/C upstream_transcript_variant
rs587776531 pathogenic, Trichothiodystrophy, nonphotosensitive 1 40,134,430(+) CCC/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SUGCT Gene

Variant ID Type Subtype PubMed ID
dgv11290n54 CNV gain 21841781
dgv11291n54 CNV loss 21841781
dgv6338n100 CNV gain 25217958
dgv6339n100 CNV loss 25217958
esv1003835 CNV insertion 20482838
esv1735710 CNV insertion 17803354
esv2581938 OTHER inversion 19546169
esv2663953 CNV deletion 23128226
esv2734304 CNV deletion 23290073
esv2734305 CNV deletion 23290073
esv2734307 CNV deletion 23290073
esv2734308 CNV deletion 23290073
esv2759525 CNV gain 17122850
esv2759526 CNV gain 17122850
esv2761115 CNV gain 21179565
esv2761320 CNV loss 21179565
esv3331018 OTHER inversion 20981092
esv3335087 OTHER inversion 20981092
esv34484 CNV gain 17911159
esv34547 CNV gain 17911159
esv3541536 CNV deletion 23714750
esv3571805 CNV loss 25503493
esv3576353 CNV gain 25503493
esv3576354 CNV gain 25503493
esv3612920 CNV gain 21293372
esv3612922 CNV gain 21293372
esv3612923 CNV gain 21293372
esv3612924 CNV loss 21293372
esv3612925 CNV loss 21293372
esv3612926 CNV loss 21293372
esv3612927 CNV loss 21293372
esv3612928 CNV loss 21293372
esv3612929 CNV loss 21293372
esv3612931 CNV loss 21293372
esv3612932 CNV gain 21293372
esv3612933 CNV loss 21293372
esv3612935 OTHER inversion 21293372
esv3891100 CNV loss 25118596
esv3891101 CNV loss 25118596
esv3891102 CNV loss 25118596
esv7091 OTHER inversion 19470904
nsv1015701 CNV gain 25217958
nsv1016800 CNV loss 25217958
nsv1017909 CNV loss 25217958
nsv1019032 CNV gain 25217958
nsv1024735 CNV gain 25217958
nsv1029342 CNV loss 25217958
nsv1032278 CNV gain 25217958
nsv1068322 OTHER inversion 25765185
nsv1109858 CNV deletion 24896259
nsv1116416 CNV insertion 24896259
nsv1117708 CNV deletion 24896259
nsv1124190 CNV deletion 24896259
nsv1129781 CNV tandem duplication 24896259
nsv1132959 CNV insertion 24896259
nsv435962 OTHER inversion 17901297
nsv464437 CNV gain 19166990
nsv475944 CNV novel sequence insertion 20440878
nsv477479 CNV novel sequence insertion 20440878
nsv509194 CNV insertion 20534489
nsv513673 OTHER inversion 21212237
nsv513674 OTHER inversion 21212237
nsv520374 CNV loss 19592680
nsv520748 CNV loss 19592680
nsv5711 CNV deletion 18451855
nsv5712 CNV insertion 18451855
nsv5713 CNV insertion 18451855
nsv606709 CNV gain 21841781
nsv7394 OTHER inversion 18451855
nsv8081 CNV gain 18304495
nsv824080 CNV gain 20364138
nsv824081 CNV loss 20364138
nsv830969 CNV gain 17160897
nsv830971 CNV gain+loss 17160897
nsv830972 CNV loss 17160897
nsv830973 CNV loss 17160897
nsv966785 CNV duplication 23825009
nsv971193 CNV duplication 23825009

Variation tolerance for SUGCT Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SUGCT Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUGCT Gene

Disorders for SUGCT Gene

MalaCards: The human disease database

(5) MalaCards diseases for SUGCT Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search SUGCT in MalaCards View complete list of genes associated with diseases


  • Glutaric aciduria 3 (GA3) [MIM:231690]: A metabolic disorder due to peroxisomal glutaryl-CoA oxidase deficiency and characterized by the excretion of abnormal quantities of glutaric acid but low 3-hydroxyglutaric acid. {ECO:0000269 PubMed:18926513, ECO:0000269 PubMed:23893049}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for SUGCT

genes like me logo Genes that share disorders with SUGCT: view

No data available for Genatlas for SUGCT Gene

Publications for SUGCT Gene

  1. C7orf10 encodes succinate-hydroxymethylglutarate CoA-transferase, the enzyme that converts glutarate to glutaryl-CoA. (PMID: 23893049) Marlaire S … Veiga-da-Cunha M (Journal of inherited metabolic disease 2014) 2 3 4 58
  2. Molecular genetic studies of human chromosome 7 in Russell-Silver syndrome. (PMID: 11829489) Nakabayashi K … Scherer SW (Genomics 2002) 2 3 4 58
  3. Genetic mapping of glutaric aciduria, type 3, to chromosome 7 and identification of mutations in c7orf10. (PMID: 18926513) Sherman EA … Puffenberger EG (American journal of human genetics 2008) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SUGCT Gene

Sources for SUGCT Gene

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