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Aliases for SUDS3 Gene

Aliases for SUDS3 Gene

  • Suppressor Of Defective Silencing 3 Homolog (S. Cerevisiae) 2 3
  • Suppressor Of Defective Silencing 3 Protein Homolog 3 4
  • 45 KDa Sin3-Associated Polypeptide 3 4
  • SAP45 3 4
  • SDS3 3 4
  • Suppressor Of Defective Silencing 3 Homolog (SDS3, S. Cerevisiae) 2
  • Sin3 Histone Deacetylase Corepressor Complex Component SDS3 3
  • Sin3A-Associated Protein, 45kDa 3
  • Sin3A-Associated Protein 2
  • 45kDa 2

External Ids for SUDS3 Gene

Previous GeneCards Identifiers for SUDS3 Gene

  • GC12P117278
  • GC12P117298
  • GC12P118814
  • GC12P115823

Summaries for SUDS3 Gene

Entrez Gene Summary for SUDS3 Gene

  • SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SUDS3 Gene

SUDS3 (Suppressor Of Defective Silencing 3 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include protein homodimerization activity and histone deacetylase binding. An important paralog of this gene is BRMS1L.

UniProtKB/Swiss-Prot for SUDS3 Gene

  • Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.

Gene Wiki entry for SUDS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUDS3 Gene

Genomics for SUDS3 Gene

Regulatory Elements for SUDS3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SUDS3 Gene

Start:
118,376,380 bp from pter
End:
118,418,035 bp from pter
Size:
41,656 bases
Orientation:
Plus strand

Genomic View for SUDS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUDS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUDS3 Gene

Proteins for SUDS3 Gene

  • Protein details for SUDS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7L9-SDS3_HUMAN
    Recommended name:
    Sin3 histone deacetylase corepressor complex component SDS3
    Protein Accession:
    Q9H7L9
    Secondary Accessions:
    • Q4KMQ5
    • Q8N6H0
    • Q9H8D2

    Protein attributes for SUDS3 Gene

    Size:
    328 amino acids
    Molecular mass:
    38136 Da
    Quaternary structure:
    • Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex (By similarity). Interacts with HCFC1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with USP17L2; the interaction is direct.
    SequenceCaution:
    • Sequence=BAB14685.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15750.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SUDS3 Gene

Proteomics data for SUDS3 Gene at MOPED

Post-translational modifications for SUDS3 Gene

  • Polyubiquitinated. Lys-63-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves Lys-63-linked ubiquitin chains.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SUDS3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SUDS3 Gene

Domains for SUDS3 Gene

Protein Domains for SUDS3 Gene

Suggested Antigen Peptide Sequences for SUDS3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H7L9

UniProtKB/Swiss-Prot:

SDS3_HUMAN :
  • Q9H7L9
Domain:
  • The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms
Family:
  • Belongs to the SDS3 family.
genes like me logo Genes that share domains with SUDS3: view

No data available for Gene Families for SUDS3 Gene

Function for SUDS3 Gene

Molecular function for SUDS3 Gene

UniProtKB/Swiss-Prot Function: Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.

Gene Ontology (GO) - Molecular Function for SUDS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004407 contributes_to histone deacetylase activity IDA 21239494
GO:0005515 protein binding IPI 12670868
GO:0019899 enzyme binding IPI 21239494
GO:0042802 identical protein binding --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with SUDS3: view

Phenotypes for SUDS3 Gene

genes like me logo Genes that share phenotypes with SUDS3: view

Animal Models for SUDS3 Gene

MGI Knock Outs for SUDS3:

Animal Model Products

CRISPR Products

miRNA for SUDS3 Gene

miRTarBase miRNAs that target SUDS3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUDS3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SUDS3 Gene

Localization for SUDS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUDS3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUDS3 Gene COMPARTMENTS Subcellular localization image for SUDS3 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SUDS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane --
GO:0016580 Sin3 complex ISS 11909966
genes like me logo Genes that share ontologies with SUDS3: view

Pathways for SUDS3 Gene

genes like me logo Genes that share pathways with SUDS3: view

Pathways by source for SUDS3 Gene

1 GeneGo (Thomson Reuters) pathway for SUDS3 Gene

Gene Ontology (GO) - Biological Process for SUDS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 22783022
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SUDS3: view

Transcripts for SUDS3 Gene

Unigene Clusters for SUDS3 Gene

Suppressor of defective silencing 3 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUDS3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUDS3 Gene

No ASD Table

Relevant External Links for SUDS3 Gene

GeneLoc Exon Structure for
SUDS3
ECgene alternative splicing isoforms for
SUDS3

Expression for SUDS3 Gene

mRNA expression in normal human tissues for SUDS3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUDS3 Gene

SOURCE GeneReport for Unigene cluster for SUDS3 Gene Hs.416630

mRNA Expression by UniProt/SwissProt for SUDS3 Gene

Q9H7L9-SDS3_HUMAN
Tissue specificity: Expressed in various cancer cell ines.
genes like me logo Genes that share expressions with SUDS3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SUDS3 Gene

Orthologs for SUDS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUDS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUDS3 35
  • 99.7 (n)
  • 100 (a)
SUDS3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUDS3 35
  • 92.07 (n)
  • 98.78 (a)
SUDS3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUDS3 35
  • 93.5 (n)
  • 99.39 (a)
SUDS3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Suds3 35
  • 87.63 (n)
  • 99.31 (a)
Suds3 16
Suds3 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUDS3 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Suds3 35
  • 88.82 (n)
  • 98.46 (a)
chicken
(Gallus gallus)
Aves SUDS3 35
  • 83.16 (n)
  • 95.19 (a)
SUDS3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUDS3 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia suds3 35
  • 79.15 (n)
  • 94.5 (a)
zebrafish
(Danio rerio)
Actinopterygii suds3 35
  • 77.78 (n)
  • 91.75 (a)
suds3 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000738 35
  • 54.9 (n)
  • 49.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14220 35
  • 51.37 (n)
  • 45.16 (a)
CG14220 36
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for SUDS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUDS3 Gene

ENSEMBL:
Gene Tree for SUDS3 (if available)
TreeFam:
Gene Tree for SUDS3 (if available)

Paralogs for SUDS3 Gene

Paralogs for SUDS3 Gene

Selected SIMAP similar genes for SUDS3 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SUDS3 Gene

genes like me logo Genes that share paralogs with SUDS3: view

Variants for SUDS3 Gene

Sequence variations from dbSNP and Humsavar for SUDS3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7795 -- 118,417,600(+) AGGTG(A/G)TGGTC utr-variant-3-prime
rs8467 -- 118,417,479(+) ATTAA(A/T)TTTTT utr-variant-3-prime
rs484838 -- 118,393,609(-) AAACA(A/G)AATCT intron-variant
rs492939 -- 118,390,950(-) ACCCA(C/T)GTGAC intron-variant
rs507517 -- 118,402,691(-) GAAGG(C/T)CAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUDS3 Gene

Variant ID Type Subtype PubMed ID
nsv899547 CNV Gain 21882294

Relevant External Links for SUDS3 Gene

HapMap Linkage Disequilibrium report
SUDS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUDS3 Gene

Disorders for SUDS3 Gene

(1) University of Copenhagen DISEASES for SUDS3 Gene

Relevant External Links for SUDS3

Genetic Association Database (GAD)
SUDS3
genes like me logo Genes that share disorders with SUDS3: view

No data available for UniProtKB/Swiss-Prot for SUDS3 Gene

Publications for SUDS3 Gene

  1. Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex. (PMID: 11909966) Alland L. … DePinho R.A. (Mol. Cell. Biol. 2002) 2 3 23
  2. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 3 4
  3. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell- proliferation factor HCF-1. (PMID: 12670868) Wysocka J. … Herr W. (Genes Dev. 2003) 3 4
  4. Identification and characterization of three new components of the mSin3A corepressor complex. (PMID: 12724404) Fleischer T.C. … Ayer D.E. (Mol. Cell. Biol. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SUDS3 Gene

Sources for SUDS3 Gene

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