Aliases for SUDS3 Gene
External Ids for SUDS3 Gene
Previous GeneCards Identifiers for SUDS3 Gene
SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SUDS3 Gene
SUDS3 (Suppressor Of Defective Silencing 3 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include protein homodimerization activity and histone deacetylase binding. An important paralog of this gene is BRMS1L.
UniProtKB/Swiss-Prot for SUDS3 Gene
Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.