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SUDS3 Gene

protein-coding   GIFtS: 53
GCID: GC12P118814

Suppressor Of Defective Silencing 3 Homolog (S. Cerevisiae)

(Previous names: suppressor of defective silencing 3 homolog (SDS3, S. cerevisiae))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppressor Of Defective Silencing 3 Homolog (S. Cerevisiae)1 2     45kDa1
Suppressor Of Defective Silencing 3 Protein Homolog2 3     Sin3A-Associated Protein1
45 KDa Sin3-Associated Polypeptide2 3     Suppressor Of Defective Silencing 3 Homolog (SDS3, S. Cerevisiae)1
SAP452 3     Sin3 Histone Deacetylase Corepressor Complex Component SDS32
SDS32 3     Sin3A-Associated Protein, 45kDa2

External Ids:    HGNC: 295451   Entrez Gene: 644262   Ensembl: ENSG000001117077   OMIM: 6082505   UniProtKB: Q9H7L93   

Export aliases for SUDS3 gene to outside databases

Previous GC identifers: GC12P117278 GC12P117298 GC12P115823


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SUDS3 Gene:
SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor
complex (Fleischer et al., 2003 (PubMed 12724404)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SUDS3 Gene:
SUDS3 (suppressor of defective silencing 3 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with SUDS3 include acute chest syndrome, and silver-russell syndrome. GO annotations related to this gene include histone deacetylase binding and protein homodimerization activity. An important paralog of this gene is BRMS1L.

UniProtKB/Swiss-Prot: SDS3_HUMAN, Q9H7L9
Function: Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May
have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly
and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and
other regulatory complexes

Gene Wiki entry for SUDS3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUDS3 gene promoter:
         TBP   p300   Lmo2   Pax-2   AP-4   Pax-2a   Evi-1   Pax-2b   TFIID   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUDS3 promoter sequence
   Search Chromatin IP Primers for SUDS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUDS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.23   Ensembl cytogenetic band:  12q24.23   HGNC cytogenetic band: 12q24.23

SUDS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUDS3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P118814:  view genomic region     (about GC identifiers)

Start:
118,814,185 bp from pter      End:
118,855,840 bp from pter
Size:
41,656 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SDS3_HUMAN, Q9H7L9 (See protein sequence)
Recommended Name: Sin3 histone deacetylase corepressor complex component SDS3  
Size: 328 amino acids; 38136 Da
Subunit: Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A.
Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex (By similarity).
Interacts with HCFC1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45,
ARID4B/SAP180, HDAC1 and HDAC2. Interacts with USP17L2; the interaction is direct
Sequence caution: Sequence=BAB14685.1; Type=Erroneous initiation; Sequence=BAB15750.1; Type=Erroneous initiation;
Secondary accessions: Q4KMQ5 Q8N6H0 Q9H8D2

Explore the universe of human proteins at neXtProt for SUDS3: NX_Q9H7L9

Explore proteomics data for SUDS3 at MOPED

Post-translational modifications: 

  • Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through
    deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SUDS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071936.2  
    ENSEMBL proteins: 
     ENSP00000443988   ENSP00000380695  
    Reactome Protein details: Q9H7L9

    SUDS3 Human Recombinant Protein Products:

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    Novus Biologicals SUDS3 Proteins
    Novus Biologicals SUDS3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SUDS3 Antibody Products:

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    SUDS3 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR013907 Sds3

    Graphical View of Domain Structure for InterPro Entry Q9H7L9

    ProtoNet protein and cluster: Q9H7L9

    2 Blocks protein domains:
    IPB011072 Protein kinase PKN/PRK1
    IPB013907 Sds3-like


    UniProtKB/Swiss-Prot: SDS3_HUMAN, Q9H7L9
    Domain: The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms
    Similarity: Belongs to the SDS3 family


    SUDS3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SDS3_HUMAN, Q9H7L9
    Function: Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May
    have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly
    and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and
    other regulatory complexes

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004407contributes to histone deacetylase activity IDA--
    GO:0005515protein binding IPI12670868
    GO:0019899enzyme binding IPI--
    GO:0042802identical protein binding ----
    GO:0042803protein homodimerization activity IEA--
         
    SUDS3 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Suds3):
     cellular  mortality/aging  normal  tumorigenesis 

    SUDS3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Suds3tm1.1Rdp for SUDS3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SUDS3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SUDS3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUDS3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUDS3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SUDS3:
    hsa-mir-197-3p (MIRT048097), hsa-mir-99a-5p (MIRT048697)

    Block miRNA regulation of human, mouse, rat SUDS3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SUDS3 (see all 43):
    hsa-miR-136 hsa-miR-25 hsa-miR-134 hsa-miR-570 hsa-miR-10b* hsa-miR-4314 hsa-miR-9 hsa-miR-629*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SUDS3
    Predesigned siRNA for gene silencing in human, mouse, rat SUDS3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SUDS3

    Clone
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    OriGene clones in human, mouse for SUDS3 (see all 8)
    OriGene ORF clones in mouse, rat for SUDS3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SUDS3 (NM_022491)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUDS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUDS3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SUDS3
    Browse ESI BIO Cell Lines and PureStem Progenitors for SUDS3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUDS3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SDS3_HUMAN, Q9H7L9: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0016580Sin3 complex ISS11909966

    SUDS3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SUDS3 About    
    See pathways by source

    SuperPathContained pathways About
    1Development NOTCH1 mediated pathway for NF KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for SUDS3
        Transcription Sin3 and NuRD in transcription regulation

    1 Reactome Pathway for SUDS3
        NoRC negatively regulates rRNA expression



    SUDS3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SUDS3
    Interactions:

        Search GeneGlobe Interaction Network for SUDS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SUDS3 (Q9H7L91, 3 ENSP000003806954) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HCFC1P516101, 3, ENSP000003095554EBI-540496,EBI-396176 I2D: score=2 STRING: ENSP00000309555
    BRMS1Q9HCU91, 3, ENSP000003960524EBI-540496,EBI-714781 I2D: score=1 STRING: ENSP00000396052
    SIN3BO751823, ENSP000003691314I2D: score=3 STRING: ENSP00000369131
    CDK5R1Q150783, ENSP000003184864I2D: score=1 STRING: ENSP00000318486
    HDAC1Q135473, ENSP000003626494I2D: score=2 STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006915apoptotic process IEA--
    GO:0016575histone deacetylation IDA--
    GO:0021762substantia nigra development IEP--

    SUDS3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SUDS3 (SDS3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SUDS3 gene: 
    NM_022491.2  

    Unigene Cluster for SUDS3:

    Suppressor of defective silencing 3 homolog (S. cerevisiae)
    Hs.416630  [show with all ESTs]
    Unigene Representative Sequence: NM_022491
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000543473(uc001twz.3) ENST00000541591 ENST00000541280 ENST00000360286
    ENST00000397564
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SUDS3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SUDS3 (see all 43):
    hsa-miR-136 hsa-miR-25 hsa-miR-134 hsa-miR-570 hsa-miR-10b* hsa-miR-4314 hsa-miR-9 hsa-miR-629*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SUDS3
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SUDS3 (NM_022491)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUDS3
    Primer
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    OriGene qPCR primer pairs and template standards for SUDS3
    OriGene qSTAR qPCR primer pairs in human, mouse for SUDS3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SUDS3
      QuantiTect SYBR Green Assays in human, mouse, rat SUDS3
      QuantiFast Probe-based Assays in human, mouse, rat SUDS3

    Additional mRNA sequence: 

    AK023801.1 AK024460.1 AK026749.1 BC030252.1 BC045728.1 BC093990.1 BC098404.1 BC112000.1 
    BX647687.1 

    7 DOTS entries:

    DT.95367211  DT.452054  DT.91882618  DT.91692302  DT.100778103  DT.100841599  DT.440184 

    Selected AceView cDNA sequences (see all 179):

    AA916093 AW590741 AI091301 AI669524 Z45726 AI598096 CR594551 AK024460 
    F04613 BF732775 BM793251 AI582531 AW264798 BU632646 CF243129 AA370774 
    BQ013915 T24560 CR625328 AA554983 BF002287 AA731882 BF725094 CA392174 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SUDS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAAATTTGC
    SUDS3 Expression
    About this image

    SUDS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUDS3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.416630

    UniProtKB/Swiss-Prot: SDS3_HUMAN, Q9H7L9
    Tissue specificity: Expressed in various cancer cell ines

        Custom PCR Arrays for SUDS3
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    QuantiFast Probe-based Assays in human, mouse, rat SUDS3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUDS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SUDS3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Suds31 , 5 suppressor of defective silencing 3 homolog (S. cerevisiae)1, 5 87.63(n)1
    99.31(a)1
      5 (56.88 cM)5
    719541  NM_178622.51  NP_848737.31 
     1170916825 
    chicken
    (Gallus gallus)
    Aves SUDS31 suppressor of defective silencing 3 homolog (S. cerevisiae) 83.16(n)
    95.19(a)
      427713  NM_001031471.1  NP_001026642.1 
    lizard
    (Anolis carolinensis)
    Reptilia SUDS36
    suppressor of defective silencing 3 homolog (S. ce...
    83(a)
    1 ↔ 1
    GL343338.1(631916-641669)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia suds31 suppressor of defective silencing 3 homolog 79.15(n)
    94.5(a)
      100170178  XM_002938086.2  XP_002938132.2 
    zebrafish
    (Danio rerio)
    Actinopterygii suds31 suppressor of defective silencing 3 homolog (SDS3, more 77.78(n)
    91.75(a)
      445099  NM_001003493.1  NP_001003493.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG142201 CG14220 51.37(n)
    45.16(a)
      32954  NM_001258830.1  NP_001245759.1 


    ENSEMBL Gene Tree for SUDS3 (if available)
    TreeFam Gene Tree for SUDS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SUDS3 gene
    BRMS1L2  BRMS12  
    1 SIMAP similar gene for SUDS3 using alignment to 4 protein entries:     SDS3_HUMAN (see all proteins):
    BRMS1L

    SUDS3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SUDS3
    PGOHUM00000235854


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SUDS3 (see all 947)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1466816131,2
    --118812928(+) TTTGGA/TCAAGA 1 -- us2k10--------
    rs47669001,2
    C,F,A,H--118812944(+) TTCTGG/AAATCC 1 -- us2k117Minor allele frequency- A:0.12NS EA NA WA 2172
    rs1818163161,2
    --118813301(+) TCCTAC/TGGAGA 1 -- us2k10--------
    rs1402949241,2
    --118813320(+) GAACAC/TAAAAG 1 -- us2k10--------
    rs1452068371,2
    C--118813375(+) TCGCTA/GCACAC 1 -- us2k10--------
    rs1863857841,2
    --118813590(+) GCTCAA/GAGCAA 1 -- us2k10--------
    rs1913277891,2
    --118813665(+) GCCTGA/GGTCTC 1 -- us2k10--------
    rs756182311,2
    C,F--118813756(+) AACATC/ATTACC 1 -- us2k13Minor allele frequency- A:0.14CSA WA 121
    rs1821355171,2
    --118813764(+) ACCGAA/GTAAAC 1 -- us2k10--------
    rs761193441,2
    C--118813768(+) AATAAA/TCCTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SUDS3 (118814185 - 118855840 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SUDS3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899547CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SUDS3
    DNA2.0 Custom Variant and Variant Library Synthesis for SUDS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608250    OMIM disorders: --

    4 diseases for SUDS3:    
    About MalaCards
    acute chest syndrome    silver-russell syndrome    malaria    breast cancer

    1 disease from the University of Copenhagen DISEASES database for SUDS3:
    Silver-Russell syndrome

    SUDS3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SUDS3

    Export disorders for SUDS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUDS3 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with SUDS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex. (PubMed id 11909966)1, 3, 9 Alland L....DePinho R.A. (Mol. Cell. Biol. 2002)
    2. Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project. (PubMed id 22443383)1, 4 Oudot-Mellakh T....Morange P.E. (Br. J. Haematol. 2012)
    3. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PubMed id 21239494)1, 2 Ramakrishna S.... Baek K.H. (J. Biol. Chem. 2011)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell- proliferation factor HCF-1. (PubMed id 12670868)1, 2 Wysocka J.... Herr W. (Genes Dev. 2003)
    8. Identification and characterization of three new components of the mSin3A corepressor complex. (PubMed id 12724404)1, 2 Fleischer T.C.... Ayer D.E. (Mol. Cell. Biol. 2003)
    9. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (DNA Res. 2000)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64426 HGNC: 29545 AceView: SDS3 Ensembl:ENSG00000111707 euGenes: HUgn64426
    ECgene: SUDS3 H-InvDB: SUDS3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SUDS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SUDS3 gene:
    Search GeneIP for patents involving SUDS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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