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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUDS3 Gene

protein-coding   GIFtS: 52
GCID: GC12P118814

Suppressor Of Defective Silencing 3 Homolog (S. Cerevisiae)

(Previous names: suppressor of defective silencing 3 homolog (SDS3, S. cerevisiae))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Suppressor Of Defective Silencing 3 Homolog (S. Cerevisiae)1 2     45kDa1
Suppressor Of Defective Silencing 3 Protein Homolog2 3     Sin3A-Associated Protein1
45 KDa Sin3-Associated Polypeptide2 3     Suppressor Of Defective Silencing 3 Homolog (SDS3, S. Cerevisiae)1
SAP452 3     Sin3 Histone Deacetylase Corepressor Complex Component SDS32
SDS32 3     Sin3A-Associated Protein, 45kDa2

External Ids:    HGNC: 295451   Entrez Gene: 644262   Ensembl: ENSG000001117077   OMIM: 6082505   UniProtKB: Q9H7L93   

Export aliases for SUDS3 gene to outside databases

Previous GC identifers: GC12P117278 GC12P117298 GC12P115823


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SUDS3 Gene:
SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor
complex (Fleischer et al., 2003 (PubMed 12724404)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SUDS3 Gene: 
SUDS3 (suppressor of defective silencing 3 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with SUDS3 include acute chest syndrome, and silver-russell syndrome, and among its related super-pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include histone deacetylase binding and protein homodimerization activity. An important paralog of this gene is BRMS1L.

UniProtKB/Swiss-Prot: SDS3_HUMAN, Q9H7L9
Function: Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May
have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly
and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and
other regulatory complexes

Gene Wiki entry for SUDS3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUDS3 gene promoter:
         TBP   p300   Lmo2   Pax-2   AP-4   Pax-2a   Evi-1   Pax-2b   TFIID   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUDS3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SUDS3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUDS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.23   Ensembl cytogenetic band:  12q24.23   HGNC cytogenetic band: 12q24.23

SUDS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUDS3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P118814:  view genomic region     (about GC identifiers)

Start:
118,814,185 bp from pter      End:
118,855,840 bp from pter
Size:
41,656 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SDS3_HUMAN, Q9H7L9 (See protein sequence)
Recommended Name: Sin3 histone deacetylase corepressor complex component SDS3  
Size: 328 amino acids; 38136 Da
Subunit: Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A.
Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex (By similarity).
Interacts with HCFC1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45,
ARID4B/SAP180, HDAC1 and HDAC2. Interacts with USP17L2; the interaction is direct
Subcellular location: Nucleus
Sequence caution: Sequence=BAB14685.1; Type=Erroneous initiation; Sequence=BAB15750.1; Type=Erroneous initiation;
Secondary accessions: Q4KMQ5 Q8N6H0 Q9H8D2

Explore the universe of human proteins at neXtProt for SUDS3: NX_Q9H7L9

Explore proteomics data for SUDS3 at MOPED 

Post-translational modifications:

  • UniProtKB: Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through
    deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H7L9

  • SUDS3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SUDS3 Protein Expression
    REFSEQ proteins: NP_071936.2  
    ENSEMBL proteins: 
     ENSP00000443988   ENSP00000380695  

    Human Recombinant Protein Products for SUDS3: 
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    OriGene MassSpec for SUDS3 
    OriGene Custom Protein Services for SUDS3
    GenScript Custom Purified and Recombinant Proteins Services for SUDS3
    Novus Biologicals SUDS3 Proteins
    Novus Biologicals SUDS3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0016580Sin3 complex ISS11909966

    SUDS3 for ontologies           About GeneDecksing



    SUDS3 Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR013907 Sds3

    Graphical View of Domain Structure for InterPro Entry Q9H7L9

    ProtoNet protein and cluster: Q9H7L9

    2 Blocks protein domains:
    IPB011072 Protein kinase PKN/PRK1
    IPB013907 Sds3-like


    UniProtKB/Swiss-Prot: SDS3_HUMAN, Q9H7L9
    Domain: The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms
    Similarity: Belongs to the SDS3 family


    SUDS3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SDS3_HUMAN, Q9H7L9
    Function: Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May
    have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly
    and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and
    other regulatory complexes

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004407contributes to histone deacetylase activity IDA--
    GO:0005515protein binding IPI12670868
    GO:0019899enzyme binding IPI--
    GO:0042802identical protein binding ----
    GO:0042803protein homodimerization activity IEA--
         
    SUDS3 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Suds3):
     cellular  mortality/aging  normal  tumorigenesis 

    SUDS3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Suds3tm1.1Rdp for SUDS3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SUDS3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SUDS3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUDS3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUDS3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUDS3
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate SUDS3 (see all 43):
    hsa-miR-136 hsa-miR-25 hsa-miR-134 hsa-miR-570 hsa-miR-10b* hsa-miR-4314 hsa-miR-9 hsa-miR-629*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SUDS3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUDS3

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SUDS3

    Clone
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    GenScript: all cDNA clones in your preferred vector: SUDS3 (NM_022491)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUDS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUDS3
    Sirion Biotech Customized lentivirus for stable overexpression of SUDS3 
                         Customized lentivirus expression plasmids for stable overexpression of SUDS3 

    Cell Line
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    Search LifeMap BioReagents cell lines for SUDS3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUDS3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SUDS3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SUDS3
        Transcription Sin3 and NuRD in transcription regulation


    1 GeneGo (Thomson Reuters) Pathway for SUDS3
        Transcription Sin3 and NuRD in transcription regulation



    SUDS3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SUDS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for SUDS3 (Q9H7L91, 3 ENSP000003806954) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HCFC1P516101, 3, ENSP000003095554EBI-540496,EBI-396176 I2D: score=2 STRING: ENSP00000309555
    BRMS1Q9HCU91, 3, ENSP000003960524EBI-540496,EBI-714781 I2D: score=1 STRING: ENSP00000396052
    SIN3BO751823, ENSP000003691314I2D: score=3 STRING: ENSP00000369131
    CDK5R1Q150783, ENSP000003184864I2D: score=1 STRING: ENSP00000318486
    SIN3AQ96ST33, ENSP000003536224I2D: score=3 STRING: ENSP00000353622
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006915apoptotic process IEA--
    GO:0016575histone deacetylation IDA--
    GO:0043065positive regulation of apoptotic process IMP--

    SUDS3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUDS3 (SDS3)

    Search CenterWatch for drugs/clinical trials and news about SUDS3 / SDS3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SUDS3 gene: 
    NM_022491.2  

    Unigene Cluster for SUDS3:

    Suppressor of defective silencing 3 homolog (S. cerevisiae)
    Hs.416630  [show with all ESTs]
    Unigene Representative Sequence: NM_022491
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000543473(uc001twz.3) ENST00000541591 ENST00000541280 ENST00000360286
    ENST00000397564
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUDS3
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate SUDS3 (see all 43):
    hsa-miR-136 hsa-miR-25 hsa-miR-134 hsa-miR-570 hsa-miR-10b* hsa-miR-4314 hsa-miR-9 hsa-miR-629*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUDS3
    Clone
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    OriGene ORF clones in mouse, rat for SUDS3
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUDS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUDS3
    Sirion Biotech Customized lentivirus for stable overexpression of SUDS3 
                         Customized lentivirus expression plasmids for stable overexpression of SUDS3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SUDS3
    OriGene qSTAR qPCR primer pairs in human, mouse for SUDS3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SUDS3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUDS3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUDS3

    Additional mRNA sequence: 

    AK023801.1 AK024460.1 AK026749.1 BC030252.1 BC045728.1 BC093990.1 BC098404.1 BC112000.1 
    BX647687.1 

    7 DOTS entries:

    DT.95367211  DT.452054  DT.91882618  DT.91692302  DT.100778103  DT.100841599  DT.440184 

    24/179 AceView cDNA sequences (see all 179):

    BF725094 BF002287 CA392174 CR594551 AK024460 AA916093 AA811413 AI669524 
    AI769614 BU632646 AW264798 CR625328 F04613 Z45726 AA554983 AI091301 
    AI598096 BQ013915 AW590741 AA370774 BF732775 T24560 CF243129 AA731882 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUDS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAAATTTGC
    SUDS3 Expression
    About this image


    See SUDS3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUDS3

    SOURCE GeneReport for Unigene cluster: Hs.416630

    UniProtKB/Swiss-Prot: SDS3_HUMAN, Q9H7L9
    Tissue specificity: Expressed in various cancer cell ines

        SABiosciences Custom PCR Arrays for SUDS3
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUDS3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUDS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SUDS3 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Suds31 , 5 suppressor of defective silencing 3 homolog (S. cerevisiae)1, 5 87.6(n)1
    97.87(a)1
      5 (56.88 cM)5
    719541  NM_178622.41  NP_848737.31 
     1170916825 
    chicken
    (Gallus gallus)
    Aves SUDS31 suppressor of defective silencing 3 homolog (S. cerevisiae) 82.05(n)
    92.63(a)
      427713  NM_001031471.1  NP_001026642.1 
    lizard
    (Anolis carolinensis)
    Reptilia SUDS36
    Uncharacterized protein
    85(a)
    1 ↔ 1
    GL343338.1(631916-641669)
    zebrafish
    (Danio rerio)
    Actinopterygii suds31 suppressor of defective silencing 3 homolog (SDS3, more 76.19(n)
    88.64(a)
      445099  NM_001003493.1  NP_001003493.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG142201 CG14220 49.77(n)
    43.54(a)
      32954  NM_134481.1  NP_608325.1 


    ENSEMBL Gene Tree for SUDS3 (if available)
    TreeFam Gene Tree for SUDS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUDS3 gene
    BRMS1L2  BRMS12  
    1 SIMAP similar gene for SUDS3 using alignment to 4 protein entries:     SDS3_HUMAN (see all proteins):
    BRMS1L

    SUDS3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SUDS3
    PGOHUM00000235854


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/947 SNPs in SUDS3 are shown (see all 947)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1466816131,2
    --118812928(+) TTTGGA/TCAAGA 1 -- us2k10--------
    rs47669001,2
    C,F,A,H--118812944(+) TTCTGG/AAATCC 1 -- us2k117Minor allele frequency- A:0.12NS EA NA WA 2172
    rs1818163161,2
    --118813301(+) TCCTAC/TGGAGA 1 -- us2k10--------
    rs1402949241,2
    --118813320(+) GAACAC/TAAAAG 1 -- us2k10--------
    rs1452068371,2
    C--118813375(+) TCGCTA/GCACAC 1 -- us2k10--------
    rs1863857841,2
    --118813590(+) GCTCAA/GAGCAA 1 -- us2k10--------
    rs1913277891,2
    --118813665(+) GCCTGA/GGTCTC 1 -- us2k10--------
    rs756182311,2
    C,F--118813756(+) AACATC/ATTACC 1 -- us2k13Minor allele frequency- A:0.14CSA WA 121
    rs1821355171,2
    --118813764(+) ACCGAA/GTAAAC 1 -- us2k10--------
    rs761193441,2
    C--118813768(+) AATAAA/TCCTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SUDS3 (118814185 - 118855840 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SUDS3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899547CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SUDS3
    DNA2.0 Custom Variant and Variant Library Synthesis for SUDS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608250    OMIM disorders: --

    3 diseases for SUDS3:    About MalaCards
    acute chest syndrome    silver-russell syndrome    breast cancer

    1 disease from the University of Copenhagen DISEASES database for SUDS3:
    Silver-Russell syndrome

    SUDS3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SUDS3

    Export disorders for SUDS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUDS3 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with SUDS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex. (PubMed id 11909966)1, 3, 9 Alland L....DePinho R.A. (2002)
    2. Genome wide association study for plasma levels of nat ural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA pr oject. (PubMed id 22443383)1, 4 Oudot-Mellakh T....Morange P.E. (2012)
    3. Lys-63-specific deubiquitination of SDS3 by USP17 reg ulates HDAC activity. (PubMed id 21239494)1, 2 Ramakrishna S....Baek K.H. (2011)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell- proliferation factor HCF-1. (PubMed id 12670868)1, 2 Wysocka J.... Herr W. (2003)
    8. Identification and characterization of three new components of the mSin3A corepressor complex. (PubMed id 12724404)1, 2 Fleischer T.C....Ayer D.E. (2003)
    9. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (2000)
    10. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64426 HGNC: 29545 AceView: SDS3 Ensembl:ENSG00000111707 euGenes: HUgn64426
    ECgene: SUDS3 H-InvDB: SUDS3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUDS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SUDS3 gene:
    Search GeneIP for patents involving SUDS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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