Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SUDS3 Gene

Aliases for SUDS3 Gene

  • SDS3 Homolog, SIN3A Corepressor Complex Component 2 3 5
  • Suppressor Of Defective Silencing 3 Protein Homolog 3 4
  • 45 KDa Sin3-Associated Polypeptide 3 4
  • Sin3A-Associated Protein, 45kDa 2 3
  • SAP45 3 4
  • SDS3 3 4
  • Suppressor Of Defective Silencing 3 Homolog (SDS3, S. Cerevisiae) 2
  • Suppressor Of Defective Silencing 3 Homolog (S. Cerevisiae) 2
  • Sin3 Histone Deacetylase Corepressor Complex Component SDS3 3

External Ids for SUDS3 Gene

Previous GeneCards Identifiers for SUDS3 Gene

  • GC12P117278
  • GC12P117298
  • GC12P118814
  • GC12P115823

Summaries for SUDS3 Gene

Entrez Gene Summary for SUDS3 Gene

  • SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SUDS3 Gene

SUDS3 (SDS3 Homolog, SIN3A Corepressor Complex Component) is a Protein Coding gene. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is BRMS1L.

UniProtKB/Swiss-Prot for SUDS3 Gene

  • Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.

Gene Wiki entry for SUDS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUDS3 Gene

Genomics for SUDS3 Gene

Regulatory Elements for SUDS3 Gene

Enhancers for SUDS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SUDS3 on UCSC Golden Path with GeneCards custom track

Promoters for SUDS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUDS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUDS3 Gene

Chromosome:
12
Start:
118,373,189 bp from pter
End:
118,418,035 bp from pter
Size:
44,847 bases
Orientation:
Plus strand

Genomic View for SUDS3 Gene

Genes around SUDS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUDS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUDS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUDS3 Gene

Proteins for SUDS3 Gene

  • Protein details for SUDS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7L9-SDS3_HUMAN
    Recommended name:
    Sin3 histone deacetylase corepressor complex component SDS3
    Protein Accession:
    Q9H7L9
    Secondary Accessions:
    • Q4KMQ5
    • Q8N6H0
    • Q9H8D2

    Protein attributes for SUDS3 Gene

    Size:
    328 amino acids
    Molecular mass:
    38136 Da
    Quaternary structure:
    • Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex (By similarity). Interacts with HCFC1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with USP17L2; the interaction is direct.
    SequenceCaution:
    • Sequence=BAB14685.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15750.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SUDS3 Gene

Post-translational modifications for SUDS3 Gene

  • Polyubiquitinated. Lys-63-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves Lys-63-linked ubiquitin chains.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SUDS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SUDS3 Gene

Domains & Families for SUDS3 Gene

Protein Domains for SUDS3 Gene

Suggested Antigen Peptide Sequences for SUDS3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H7L9

UniProtKB/Swiss-Prot:

SDS3_HUMAN :
  • The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.
  • Belongs to the SDS3 family.
Domain:
  • The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.
Family:
  • Belongs to the SDS3 family.
genes like me logo Genes that share domains with SUDS3: view

No data available for Gene Families for SUDS3 Gene

Function for SUDS3 Gene

Molecular function for SUDS3 Gene

UniProtKB/Swiss-Prot Function:
Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.

Gene Ontology (GO) - Molecular Function for SUDS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004407 histone deacetylase activity TAS --
GO:0005515 protein binding IPI 12670868
GO:0019899 enzyme binding IPI 21239494
GO:0042826 histone deacetylase binding ISS 11909966
genes like me logo Genes that share ontologies with SUDS3: view
genes like me logo Genes that share phenotypes with SUDS3: view

Animal Models for SUDS3 Gene

MGI Knock Outs for SUDS3:

Animal Model Products

CRISPR Products

miRNA for SUDS3 Gene

miRTarBase miRNAs that target SUDS3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUDS3 Gene

Localization for SUDS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUDS3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUDS3 Gene COMPARTMENTS Subcellular localization image for SUDS3 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for SUDS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21239494
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0016580 Sin3 complex ISS 11909966
GO:0070822 Sin3-type complex IBA --
genes like me logo Genes that share ontologies with SUDS3: view

Pathways & Interactions for SUDS3 Gene

genes like me logo Genes that share pathways with SUDS3: view

Pathways by source for SUDS3 Gene

Gene Ontology (GO) - Biological Process for SUDS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 22783022
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0016575 histone deacetylation IDA 21239494
GO:0021762 substantia nigra development IEP 22926577
genes like me logo Genes that share ontologies with SUDS3: view

No data available for SIGNOR curated interactions for SUDS3 Gene

Drugs & Compounds for SUDS3 Gene

No Compound Related Data Available

Transcripts for SUDS3 Gene

Unigene Clusters for SUDS3 Gene

Suppressor of defective silencing 3 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUDS3 Gene

No ASD Table

Relevant External Links for SUDS3 Gene

GeneLoc Exon Structure for
SUDS3
ECgene alternative splicing isoforms for
SUDS3

Expression for SUDS3 Gene

mRNA expression in normal human tissues for SUDS3 Gene

Protein differential expression in normal tissues from HIPED for SUDS3 Gene

This gene is overexpressed in Pancreas (30.2) and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUDS3 Gene



Protein tissue co-expression partners for SUDS3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SUDS3 Gene:

SUDS3

SOURCE GeneReport for Unigene cluster for SUDS3 Gene:

Hs.416630

mRNA Expression by UniProt/SwissProt for SUDS3 Gene:

Q9H7L9-SDS3_HUMAN
Tissue specificity: Expressed in various cancer cell ines.
genes like me logo Genes that share expression patterns with SUDS3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SUDS3 Gene

Orthologs for SUDS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUDS3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUDS3 34
  • 92.07 (n)
  • 98.78 (a)
SUDS3 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUDS3 34
  • 93.5 (n)
  • 99.39 (a)
SUDS3 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Suds3 34
  • 87.63 (n)
  • 99.31 (a)
Suds3 16
Suds3 35
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUDS3 34
  • 99.7 (n)
  • 100 (a)
SUDS3 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Suds3 34
  • 88.82 (n)
  • 98.46 (a)
oppossum
(Monodelphis domestica)
Mammalia SUDS3 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUDS3 34
  • 83.16 (n)
  • 95.19 (a)
SUDS3 35
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUDS3 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia suds3 34
  • 79.15 (n)
  • 94.5 (a)
zebrafish
(Danio rerio)
Actinopterygii suds3 34
  • 77.78 (n)
  • 91.75 (a)
suds3 35
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000738 34
  • 54.9 (n)
  • 49.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14220 34
  • 51.37 (n)
  • 45.16 (a)
CG14220 35
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToOne
Species where no ortholog for SUDS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUDS3 Gene

ENSEMBL:
Gene Tree for SUDS3 (if available)
TreeFam:
Gene Tree for SUDS3 (if available)

Paralogs for SUDS3 Gene

Paralogs for SUDS3 Gene

(1) SIMAP similar genes for SUDS3 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SUDS3 Gene

genes like me logo Genes that share paralogs with SUDS3: view

Variants for SUDS3 Gene

Sequence variations from dbSNP and Humsavar for SUDS3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7301285 -- 118,393,949(+) tgtag(C/G)tgtga intron-variant
rs7304342 -- 118,390,166(+) ACTCA(C/T)CCCTA intron-variant
rs7305467 -- 118,394,804(+) cctca(A/G)cctcc intron-variant
rs7305647 -- 118,417,761(+) GATAA(A/G)TGATA downstream-variant-500B, utr-variant-3-prime
rs7307953 -- 118,412,843(+) AAACA(C/T)GTCTT intron-variant

Variation tolerance for SUDS3 Gene

Residual Variation Intolerance Score: 19.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUDS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUDS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SUDS3 Gene

Disorders for SUDS3 Gene

Relevant External Links for SUDS3

Genetic Association Database (GAD)
SUDS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUDS3

No disorders were found for SUDS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUDS3 Gene

Publications for SUDS3 Gene

  1. Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex. (PMID: 11909966) Alland L. … DePinho R.A. (Mol. Cell. Biol. 2002) 2 3 22 65
  2. Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project. (PMID: 22443383) Oudot-Mellakh T. … Morange P.E. (Br. J. Haematol. 2012) 3 46 65
  3. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S. … Baek K.H. (J. Biol. Chem. 2011) 3 4 65
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for SUDS3 Gene

Sources for SUDS3 Gene

Content