SUCO Gene
protein-coding GIFtS: 40
GCID: GC01P172502
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|
SUN domain containing ossification factor(Previous name: chromosome 1 open reading frame 9 )
(Previous symbol: C1orf9)
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Aliases
for SUCO gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SUN Domain Containing Ossification Factor1 2 | | Protein Osteopotentia Homolog2 3 | | C1orf91 2 3 | | SUN-Like Protein 12 3 | | CH11 2 3 | | Chromosome 1 Open Reading Frame 91 | | OPT1 2 3 | | Osteopotentia1 | | SLP11 2 3 | | Protein C1orf92 | | Membrane Protein CH12 3 | | SUN Domain-Containing Ossification Factor2 |
Export aliases for SUCO gene to outside databases |
Summaries
for SUCO gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SUCO_HUMAN, Q9UBS9Function: Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblastsduring their postnatal maturation (By similarity)
|
Genomic Views
for SUCO gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SUCO
Other transcription factors
Search SABiosciences Chromatin IP Primers for SUCO
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUCO |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q24 Ensembl cytogenetic band: 1q24.3 HGNC cytogenetic band: 1q24SUCO Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P172502: view genomic region
(about GC identifiers)
Start:
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172,501,489 bp from pter |
End:
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172,580,973 bp from pter |
Size:
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79,485 bases |
Orientation:
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plus strand |
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Proteins
for SUCO gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SUCO_HUMAN, Q9UBS9 (See
protein sequence)Recommended Name: SUN domain-containing ossification factor precursor Size: 1254 amino acids; 139430 Da
Subcellular location: Rough endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: B2RNU4 Q9BQB9 Q9BXQ2 Q9UL04Alternative splicing: 2 isoforms: Q9UBS9-1 Q9UBS9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SUCO: NX_Q9UBS9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UBS9
SUCO Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_055098.1 NP_057311.2
ENSEMBL proteins: ENSP00000356696 ENSP00000263688
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
SUCO for ontologies About GeneDecksing
SUCO Antibody Products:
Assay Products for SUCO: |
Protein
Domains /
Families
for SUCO gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SUCO for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UBS9ProtoNet protein and cluster: Q9UBS9 1 Blocks protein family: IPB012919 Sad1/UNC-like
UniProtKB/Swiss-Prot: SUCO_HUMAN, Q9UBS9Similarity: Contains 1 SUN domain |
Function
for SUCO gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SUCO_HUMAN, Q9UBS9Function: Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblastsduring their postnatal maturation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUCO (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUCO (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for SUCO | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SUCO | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUCO |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUCO |
Animal Models:
13 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Suco):
SUCO for phenotypes About GeneDecksing
|
Pathways & Interactions
for SUCO gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SUCO
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SUCO (Q9UBS93 ENSP000002636884) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001503 | ossification |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0032967 | positive regulation of collagen biosynthetic process |
ISS | -- | | GO:0045669 | positive regulation of osteoblast differentiation |
ISS | -- | | GO:0046850 | regulation of bone remodeling |
ISS | -- |
SUCO for ontologies About GeneDecksing
|
Drugs & Compounds
for SUCO gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SUCO
Search CenterWatch for drugs/clinical trials and news about SUCO
|
Transcripts
for SUCO gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SUCO gene (2 alternative transcripts): NM_014283.3 NM_016227.2 Unigene Cluster for SUCO: SUN domain containing ossification factor Hs.743437 [show with all ESTs]Unigene Representative Sequence: AF0975353 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367723(uc009wwd.3 uc010pmn.2) ENST00000263688(uc010pmm.1 uc001giq.4 uc010pmo.2)
ENST00000486569
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUCO (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUCO (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SUCO | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SUCO | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUCO |
Additional cDNA sequence: AF097535.1 AJ250075.1 AK302509.1 AK302949.1 AL035291.1 BC137125.1 BC144487.1 11 DOTS entries: DT.413557 DT.100647351 DT.100866144 DT.121326268 DT.40299593 DT.92015194 DT.121326269 DT.92047010 DT.95299101 DT.100001520 DT.100667348 24/180 AceView cDNA sequences (see all 180): AW182005 AW440787 AW771622 AI694201 CA312507 BM129656 AA235936 AI142894 CD656830 AA373313 BX362150 AA236951 AI217893 AW161494 BU190107 AW614609 AA481703 BU156205 AW873108 CR603786 H88718 C00478 AW300518 N22982
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SUCO (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SUCO
|
Expression
for SUCO gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See SUCO Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SUCO
SOURCE GeneReport for Unigene cluster: Hs.743437
UniProtKB/Swiss-Prot: SUCO_HUMAN, Q9UBS9Tissue specificity: Highly expressed in pancreas and testis and to a lower extent in prostate, ovary, heart, thymus,small intestine and spleen
SABiosciences Custom PCR Arrays for SUCO
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SUCO | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUCO | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUCO | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUCO |
Orthologs
for SUCO gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SUCO gene from 9/25 species (see all 25) About this table
ENSEMBL Gene Tree for SUCO (if available)
TreeFam Gene Tree for SUCO (if available) |
Paralogs
for SUCO gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SUCO gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SUCO (172501489 - 172580973 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SUCO: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SUCO |
|
Disorders
/ Diseases
for SUCO gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SUCO for disorders About GeneDecksing
3  diseases for SUCO: About MalaCardsfanconi's anemia anemia prostatitis
Export disorders for SUCO gene to outside databases
|
Publications
for SUCO gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SUCO gene integrated from 9 sources:
(articles sorted by number of sources associating them with SUCO) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The C1orf9 gene encodes a putative transmembrane member of a novel protein family. (PubMed id 10673381)1, 2, 3 Roesok O.... Aasheim H.-C. (2000)
- Osteopotentia regulates osteoblast maturation, bone fo rmation, and skeletal integrity in mice. (PubMed id 20440000)1, 3 Sohaskey M.L....Harland R.M. (2010)
- Global patterns of human DNA sequence variation in a 10-kb region on chromosome 1. (PubMed id 11158380)1, 2 Yu N.... Li W.-H. (2001)
- TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SUCO gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SUCO gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SUCO gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SUCO gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SUCO | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SUCO gene:
Search GeneIP for patents involving SUCO
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SUCO gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SUCO | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUCO | | Browse OriGene genome-wide validated SYBR primer pairs | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SUCO | | OriGene 3'-UTR Clone for SUCO | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUCO | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUCO | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SUCO | | OriGene Custom Protein Services for SUCO | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SUCO | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SUCO | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUCO | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUCO | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUCO | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUCO |
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 |  |  |  | |
| | | | Search Tocris compounds for SUCO |
| |  |  |  |  | | | | |
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 | | | SUCO Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUCO |
|  |  |  | | | | Search ThermoFisher Antibodies for SUCO |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUCO |
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