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Aliases for SUCO Gene

Aliases for SUCO Gene

  • SUN Domain Containing Ossification Factor 2 3 5
  • SUN-Like Protein 1 2 3 4
  • Membrane Protein CH1 3 4
  • Osteopotentia 2 3
  • C1orf9 3 4
  • SLP1 3 4
  • OPT 3 4
  • CH1 3 4
  • Chromosome 1 Open Reading Frame 9 2
  • Protein Osteopotentia Homolog 4

External Ids for SUCO Gene

Previous HGNC Symbols for SUCO Gene

  • C1orf9

Summaries for SUCO Gene

GeneCards Summary for SUCO Gene

SUCO (SUN Domain Containing Ossification Factor) is a Protein Coding gene. Diseases associated with SUCO include gamma heavy chain disease and taeniasis.

UniProtKB/Swiss-Prot for SUCO Gene

  • Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUCO Gene

Genomics for SUCO Gene

Regulatory Elements for SUCO Gene

Promoters for SUCO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUCO on UCSC Golden Path with GeneCards custom track

Genomic Location for SUCO Gene

Chromosome:
1
Start:
172,532,349 bp from pter
End:
172,611,833 bp from pter
Size:
79,485 bases
Orientation:
Plus strand

Genomic View for SUCO Gene

Genes around SUCO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUCO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUCO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUCO Gene

Proteins for SUCO Gene

  • Protein details for SUCO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBS9-SUCO_HUMAN
    Recommended name:
    SUN domain-containing ossification factor
    Protein Accession:
    Q9UBS9
    Secondary Accessions:
    • B2RNU4
    • Q9BQB9
    • Q9BXQ2
    • Q9UL04

    Protein attributes for SUCO Gene

    Size:
    1254 amino acids
    Molecular mass:
    139430 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SUCO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUCO Gene

Proteomics data for SUCO Gene at MOPED

Post-translational modifications for SUCO Gene

  • Glycosylation at Asn 202, Asn 236, Asn 524, Asn 928, and Asn 955
  • Modification sites at PhosphoSitePlus

Other Protein References for SUCO Gene

No data available for DME Specific Peptides for SUCO Gene

Domains & Families for SUCO Gene

Protein Domains for SUCO Gene

Suggested Antigen Peptide Sequences for SUCO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBS9

UniProtKB/Swiss-Prot:

SUCO_HUMAN :
  • Contains 1 SUN domain.
Domain:
  • Contains 1 SUN domain.
genes like me logo Genes that share domains with SUCO: view

No data available for Gene Families for SUCO Gene

Function for SUCO Gene

Molecular function for SUCO Gene

UniProtKB/Swiss-Prot Function:
Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity).
genes like me logo Genes that share phenotypes with SUCO: view

Animal Model Products

CRISPR Products

miRNA for SUCO Gene

miRTarBase miRNAs that target SUCO

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUCO Gene

Localization for SUCO Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUCO Gene

Rough endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUCO Gene COMPARTMENTS Subcellular localization image for SUCO gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
extracellular 2
nucleus 2
plasma membrane 2
chloroplast 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SUCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SUCO: view

Pathways & Interactions for SUCO Gene

SuperPathways for SUCO Gene

No Data Available

Gene Ontology (GO) - Biological Process for SUCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0046850 regulation of bone remodeling ISS --
genes like me logo Genes that share ontologies with SUCO: view

No data available for Pathways by source and SIGNOR curated interactions for SUCO Gene

Drugs & Compounds for SUCO Gene

No Compound Related Data Available

Transcripts for SUCO Gene

Unigene Clusters for SUCO Gene

SUN domain containing ossification factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUCO Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: -
SP3:
SP4:
SP5: - -
SP6:

Relevant External Links for SUCO Gene

GeneLoc Exon Structure for
SUCO
ECgene alternative splicing isoforms for
SUCO

Expression for SUCO Gene

mRNA expression in normal human tissues for SUCO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SUCO Gene

This gene is overexpressed in Bone (21.8), Plasma (17.9), Adrenal (15.1), and Neutrophil (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUCO Gene



SOURCE GeneReport for Unigene cluster for SUCO Gene Hs.204559

mRNA Expression by UniProt/SwissProt for SUCO Gene

Q9UBS9-SUCO_HUMAN
Tissue specificity: Highly expressed in pancreas and testis and to a lower extent in prostate, ovary, heart, thymus, small intestine and spleen.
genes like me logo Genes that share expression patterns with SUCO: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SUCO Gene

Orthologs for SUCO Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUCO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUCO 35
  • 91.41 (n)
  • 88.64 (a)
SUCO 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUCO 35
  • 91.17 (n)
  • 89.03 (a)
SUCO 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Suco 35
  • 88.1 (n)
  • 86.47 (a)
Suco 16
Suco 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUCO 35
  • 99.73 (n)
  • 99.44 (a)
SUCO 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Suco 35
  • 86.86 (n)
  • 84.51 (a)
oppossum
(Monodelphis domestica)
Mammalia SUCO 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUCO 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves C8H1ORF9 35
  • 73.2 (n)
  • 71.22 (a)
SUCO 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia suco 35
  • 65.78 (n)
  • 62.44 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
suco 35
  • 54.8 (n)
  • 54.18 (a)
suco 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31678 36
  • 18 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R12E2.2 36
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLP1 36
  • 26 (a)
OneToOne
SLP1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13589 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToOne
Species with no ortholog for SUCO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUCO Gene

ENSEMBL:
Gene Tree for SUCO (if available)
TreeFam:
Gene Tree for SUCO (if available)

Paralogs for SUCO Gene

No data available for Paralogs for SUCO Gene

Variants for SUCO Gene

Sequence variations from dbSNP and Humsavar for SUCO Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs964798 -- 172,534,836(+) CTTTC(C/T)TCTTT intron-variant
rs1053380 -- 172,610,952(+) AAAAT(A/C)CCTAC utr-variant-3-prime
rs1053381 -- 172,611,397(+) CAGTA(A/G)TGAAT utr-variant-3-prime
rs1159378 -- 172,553,462(+) GTATT(A/G)TTAGT intron-variant
rs1557561 -- 172,552,746(+) GTCAT(A/G)AAAGT intron-variant

Variation tolerance for SUCO Gene

Residual Variation Intolerance Score: 8.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.61; 91.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUCO Gene

HapMap Linkage Disequilibrium report
SUCO
Human Gene Mutation Database (HGMD)
SUCO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SUCO Gene

Disorders for SUCO Gene

MalaCards: The human disease database

(2) MalaCards diseases for SUCO Gene - From: DISEASES

Disorder Aliases PubMed IDs
gamma heavy chain disease
  • franklin's disease
taeniasis
  • beef tapeworm infection
- elite association - COSMIC cancer census association via MalaCards
Search SUCO in MalaCards View complete list of genes associated with diseases

Relevant External Links for SUCO

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUCO
genes like me logo Genes that share disorders with SUCO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUCO Gene

Publications for SUCO Gene

  1. The C1orf9 gene encodes a putative transmembrane member of a novel protein family. (PMID: 10673381) Roesok O. … Aasheim H.-C. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 67
  2. Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice. (PMID: 20440000) Sohaskey M.L. … Harland R.M. (J. Cell Biol. 2010) 2 3
  3. Exome sequencing identifies SUCO mutations in mesial temporal lobe epilepsy. (PMID: 25668491) Sha Z. … Xu Q. (Neurosci. Lett. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for SUCO Gene

Sources for SUCO Gene

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