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Aliases for SUCO Gene

Aliases for SUCO Gene

  • SUN Domain Containing Ossification Factor 2 3
  • SUN-Like Protein 1 2 3 4
  • Membrane Protein CH1 3 4
  • Osteopotentia 2 3
  • C1orf9 3 4
  • SLP1 3 4
  • OPT 3 4
  • CH1 3 4
  • SUN Domain-Containing Ossification Factor 3
  • Chromosome 1 Open Reading Frame 9 2
  • Protein Osteopotentia Homolog 4

External Ids for SUCO Gene

Previous HGNC Symbols for SUCO Gene

  • C1orf9

Summaries for SUCO Gene

GeneCards Summary for SUCO Gene

SUCO (SUN Domain Containing Ossification Factor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SUCO Gene

  • Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUCO Gene

Genomics for SUCO Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SUCO Gene

Start:
172,532,349 bp from pter
End:
172,611,833 bp from pter
Size:
79,485 bases
Orientation:
Plus strand

Genomic View for SUCO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUCO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUCO Gene

No data available for Regulatory Elements for SUCO Gene

Proteins for SUCO Gene

  • Protein details for SUCO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBS9-SUCO_HUMAN
    Recommended name:
    SUN domain-containing ossification factor
    Protein Accession:
    Q9UBS9
    Secondary Accessions:
    • B2RNU4
    • Q9BQB9
    • Q9BXQ2
    • Q9UL04

    Protein attributes for SUCO Gene

    Size:
    1254 amino acids
    Molecular mass:
    139430 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SUCO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUCO Gene

Proteomics data for SUCO Gene at MOPED

Post-translational modifications for SUCO Gene

  • Glycosylation at Asn202, Asn236, Asn524, Asn928, and Asn955
  • Modification sites at PhosphoSitePlus

Other Protein References for SUCO Gene

No data available for DME Specific Peptides for SUCO Gene

Domains for SUCO Gene

Protein Domains for SUCO Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBS9

UniProtKB/Swiss-Prot:

SUCO_HUMAN :
  • Q9UBS9
Domain:
  • Contains 1 SUN domain.
genes like me logo Genes that share domains with SUCO: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SUCO Gene

Function for SUCO Gene

Molecular function for SUCO Gene

UniProtKB/Swiss-Prot Function: Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity).
genes like me logo Genes that share phenotypes with SUCO: view

Animal Model Products

CRISPR Products

miRNA for SUCO Gene

miRTarBase miRNAs that target SUCO

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SUCO Gene

Localization for SUCO Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUCO Gene

Rough endoplasmic reticulum membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for SUCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005791 rough endoplasmic reticulum ISS --
GO:0016020 membrane ISS --
GO:0016021 integral component of membrane IEA --
GO:0030867 rough endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with SUCO: view

No data available for Subcellular locations from COMPARTMENTS for SUCO Gene

Pathways for SUCO Gene

SuperPathways for SUCO Gene

No Data Available

Gene Ontology (GO) - Biological Process for SUCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0007275 multicellular organismal development IEA --
GO:0032967 positive regulation of collagen biosynthetic process ISS --
GO:0045669 positive regulation of osteoblast differentiation ISS --
GO:0046850 regulation of bone remodeling ISS --
genes like me logo Genes that share ontologies with SUCO: view

No data available for Pathways by source for SUCO Gene

Transcripts for SUCO Gene

Unigene Clusters for SUCO Gene

SUN domain containing ossification factor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUCO

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUCO Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: -
SP3:
SP4:
SP5: - -
SP6:

Relevant External Links for SUCO Gene

GeneLoc Exon Structure for
SUCO
ECgene alternative splicing isoforms for
SUCO

Expression for SUCO Gene

mRNA expression in normal human tissues for SUCO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUCO Gene

SOURCE GeneReport for Unigene cluster for SUCO Gene Hs.204559

mRNA Expression by UniProt/SwissProt for SUCO Gene

Q9UBS9-SUCO_HUMAN
Tissue specificity: Highly expressed in pancreas and testis and to a lower extent in prostate, ovary, heart, thymus, small intestine and spleen.
genes like me logo Genes that share expressions with SUCO: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SUCO Gene

Orthologs for SUCO Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUCO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUCO 35
  • 99.73 (n)
  • 99.44 (a)
SUCO 36
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUCO 35
  • 91.41 (n)
  • 88.64 (a)
SUCO 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUCO 35
  • 91.17 (n)
  • 89.03 (a)
SUCO 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Suco 35
  • 88.1 (n)
  • 86.47 (a)
Suco 16
Suco 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUCO 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUCO 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Suco 35
  • 86.86 (n)
  • 84.51 (a)
chicken
(Gallus gallus)
Aves C8H1ORF9 35
  • 73.2 (n)
  • 71.22 (a)
SUCO 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia suco 35
  • 65.78 (n)
  • 62.44 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
suco 35
  • 54.8 (n)
  • 54.18 (a)
suco 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31678 36
  • 18 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R12E2.2 36
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLP1 36
  • 26 (a)
OneToOne
SLP1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13589 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToOne
Species with no ortholog for SUCO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUCO Gene

ENSEMBL:
Gene Tree for SUCO (if available)
TreeFam:
Gene Tree for SUCO (if available)

Paralogs for SUCO Gene

No data available for Paralogs for SUCO Gene

Variants for SUCO Gene

Sequence variations from dbSNP and Humsavar for SUCO Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs964798 -- 172,534,836(+) CTTTC(C/T)TCTTT intron-variant
rs1053380 -- 172,610,952(+) AAAAT(A/C)CCTAC utr-variant-3-prime
rs1053381 -- 172,611,397(+) CAGTA(A/G)TGAAT utr-variant-3-prime
rs1159378 -- 172,553,462(+) GTATT(A/G)TTAGT intron-variant
rs1557561 -- 172,552,746(+) GTCAT(A/G)AAAGT intron-variant

Relevant External Links for SUCO Gene

HapMap Linkage Disequilibrium report
SUCO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SUCO Gene

Disorders for SUCO Gene

No disorders were found for SUCO Gene.

No data available for UniProtKB/Swiss-Prot for SUCO Gene

Publications for SUCO Gene

  1. The C1orf9 gene encodes a putative transmembrane member of a novel protein family. (PMID: 10673381) Roesok O. … Aasheim H.-C. (Biochem. Biophys. Res. Commun. 2000) 2 3 4
  2. Global patterns of human DNA sequence variation in a 10-kb region on chromosome 1. (PMID: 11158380) Yu N. … Li W.-H. (Mol. Biol. Evol. 2001) 3 4
  3. Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice. (PMID: 20440000) Sohaskey M.L. … Harland R.M. (J. Cell Biol. 2010) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for SUCO Gene

Sources for SUCO Gene

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