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Aliases for SUCO Gene

Aliases for SUCO Gene

  • SUN Domain Containing Ossification Factor 2 3 5
  • SUN-Like Protein 1 2 3 4
  • Membrane Protein CH1 3 4
  • Osteopotentia 2 3
  • C1orf9 3 4
  • SLP1 3 4
  • OPT 3 4
  • CH1 3 4
  • SUN Domain-Containing Ossification Factor 3
  • Chromosome 1 Open Reading Frame 9 2
  • Protein Osteopotentia Homolog 4

External Ids for SUCO Gene

Previous HGNC Symbols for SUCO Gene

  • C1orf9

Summaries for SUCO Gene

GeneCards Summary for SUCO Gene

SUCO (SUN Domain Containing Ossification Factor) is a Protein Coding gene. Diseases associated with SUCO include Gamma Heavy Chain Disease and Microvascular Complications Of Diabetes 7.

UniProtKB/Swiss-Prot for SUCO Gene

  • Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUCO Gene

Genomics for SUCO Gene

Regulatory Elements for SUCO Gene

Enhancers for SUCO Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G172448 1.6 Ensembl ENCODE dbSUPER 21.1 -81.1 -81078 6.4 PKNOX1 FOXA2 WRNIP1 ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF143 C1orf105 PIGC SUCO LOC102724528
GH01G172496 1.5 Ensembl ENCODE dbSUPER 20.6 -33.2 -33237 5.1 PKNOX1 FOXA2 ATF1 MLX SIN3A ARID4B YY1 FOS SP5 MXD4 SUCO PIGC C1orf105 LOC102724528
GH01G172475 1.3 ENCODE dbSUPER 22.4 -54.3 -54317 5.5 PKNOX1 FOXA2 ARID4B DMAP1 FEZF1 ZNF48 ZNF2 ZNF766 GATA2 FOS C1orf105 PIGC SUCO LOC102724528
GH01G172470 1.2 ENCODE dbSUPER 22.1 -62.0 -62034 0.2 ELF3 FOXA2 ATF1 MLX ARID4B RAD21 THRB ZSCAN9 RARA GATA4 SUCO PIGC C1orf105 RNU6-157P LOC102724528
GH01G172662 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.7 +131.0 131021 2.2 PKNOX1 CBX3 NFIB FEZF1 ZBTB40 TCF12 SCRT2 RELB FOS ETV6 FASLG SUCO SLC25A38P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SUCO on UCSC Golden Path with GeneCards custom track

Promoters for SUCO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SUCO Gene

172,532,349 bp from pter
172,611,833 bp from pter
79,485 bases
Plus strand

Genomic View for SUCO Gene

Genes around SUCO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUCO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUCO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUCO Gene

Proteins for SUCO Gene

  • Protein details for SUCO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SUN domain-containing ossification factor
    Protein Accession:
    Secondary Accessions:
    • B2RNU4
    • Q9BQB9
    • Q9BXQ2
    • Q9UL04

    Protein attributes for SUCO Gene

    1254 amino acids
    Molecular mass:
    139430 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SUCO Gene


neXtProt entry for SUCO Gene

Post-translational modifications for SUCO Gene

  • Glycosylation at Asn202, isoforms=2236, posLast=524524, posLast=928928, and Asn955
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SUCO Gene

Domains & Families for SUCO Gene

Protein Domains for SUCO Gene

Suggested Antigen Peptide Sequences for SUCO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SUCO: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SUCO Gene

Function for SUCO Gene

Molecular function for SUCO Gene

UniProtKB/Swiss-Prot Function:
Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity).
genes like me logo Genes that share phenotypes with SUCO: view

Animal Model Products

CRISPR Products

miRNA for SUCO Gene

miRTarBase miRNAs that target SUCO

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUCO Gene

Localization for SUCO Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUCO Gene

Rough endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUCO gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
extracellular 2
nucleus 2
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SUCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005791 rough endoplasmic reticulum ISS --
GO:0016020 membrane ISS --
GO:0016021 integral component of membrane IEA --
GO:0030867 rough endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with SUCO: view

Pathways & Interactions for SUCO Gene

No Data Available

Gene Ontology (GO) - Biological Process for SUCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0007275 multicellular organism development IEA --
GO:0032967 positive regulation of collagen biosynthetic process ISS --
GO:0045669 positive regulation of osteoblast differentiation ISS --
GO:0046850 regulation of bone remodeling ISS --
genes like me logo Genes that share ontologies with SUCO: view

No data available for Pathways by source and SIGNOR curated interactions for SUCO Gene

Drugs & Compounds for SUCO Gene

No Compound Related Data Available

Transcripts for SUCO Gene

Unigene Clusters for SUCO Gene

SUN domain containing ossification factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUCO Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP2: -
SP5: - -

Relevant External Links for SUCO Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SUCO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUCO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SUCO Gene

This gene is overexpressed in Bone (21.8), Plasma (17.9), Adrenal (15.1), and Neutrophil (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUCO Gene

NURSA nuclear receptor signaling pathways regulating expression of SUCO Gene:


SOURCE GeneReport for Unigene cluster for SUCO Gene:


mRNA Expression by UniProt/SwissProt for SUCO Gene:

Tissue specificity: Highly expressed in pancreas and testis and to a lower extent in prostate, ovary, heart, thymus, small intestine and spleen.

Evidence on tissue expression from TISSUES for SUCO Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SUCO: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUCO Gene

Orthologs for SUCO Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUCO Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SUCO 34 35
  • 99.73 (n)
(Bos Taurus)
Mammalia SUCO 34 35
  • 91.41 (n)
(Canis familiaris)
Mammalia SUCO 34 35
  • 91.17 (n)
(Mus musculus)
Mammalia Suco 34 16 35
  • 88.1 (n)
(Rattus norvegicus)
Mammalia Suco 34
  • 86.86 (n)
(Monodelphis domestica)
Mammalia SUCO 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia SUCO 35
  • 75 (a)
(Gallus gallus)
Aves C8H1ORF9 34
  • 73.2 (n)
  • 69 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 81 (a)
-- 35
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia suco 34
  • 65.78 (n)
(Danio rerio)
Actinopterygii suco 34 35
  • 54.8 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG31678 35
  • 18 (a)
(Caenorhabditis elegans)
Secernentea R12E2.2 35
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLP1 35 37
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13589 34
Species where no ortholog for SUCO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUCO Gene

Gene Tree for SUCO (if available)
Gene Tree for SUCO (if available)

Paralogs for SUCO Gene

No data available for Paralogs for SUCO Gene

Variants for SUCO Gene

Sequence variations from dbSNP and Humsavar for SUCO Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000027110 -- 172,535,503(+) CTCTG(C/G)TTTTG intron-variant
rs1000096698 -- 172,588,083(+) GGCTT(A/C)GAAGA intron-variant
rs1000120342 -- 172,540,258(+) TGGTA(A/G)ATGGT intron-variant
rs1000149093 -- 172,605,242(+) GAAAT(A/C)ATTAT intron-variant
rs1000153355 -- 172,568,057(+) TGCAC(A/C)TGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUCO Gene

Variant ID Type Subtype PubMed ID
esv7885 CNV loss 19470904
nsv3554 CNV insertion 18451855

Variation tolerance for SUCO Gene

Residual Variation Intolerance Score: 8.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.61; 91.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUCO Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUCO Gene

Disorders for SUCO Gene

MalaCards: The human disease database

(5) MalaCards diseases for SUCO Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gamma heavy chain disease
  • franklin's disease
microvascular complications of diabetes 7
  • diabetic nephropathy
  • beef tapeworm infection
heavy chain disease
  • hcd
background diabetic retinopathy
  • non proliferative diabetic retinopathy
- elite association - COSMIC cancer census association via MalaCards
Search SUCO in MalaCards View complete list of genes associated with diseases

Relevant External Links for SUCO

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SUCO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUCO Gene

Publications for SUCO Gene

  1. The C1orf9 gene encodes a putative transmembrane member of a novel protein family. (PMID: 10673381) Roesok O. … Aasheim H.-C. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 64
  2. Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice. (PMID: 20440000) Sohaskey M.L. … Harland R.M. (J. Cell Biol. 2010) 2 3 64
  3. Global patterns of human DNA sequence variation in a 10-kb region on chromosome 1. (PMID: 11158380) Yu N. … Li W.-H. (Mol. Biol. Evol. 2001) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for SUCO Gene

Sources for SUCO Gene

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