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Aliases for SUCNR1 Gene

Aliases for SUCNR1 Gene

  • Succinate Receptor 1 2 3 5
  • G-Protein Coupled Receptor 91 3 4
  • GPR91 3 4
  • G Protein-Coupled Receptor 91 2
  • P2Y Purinoceptor 1-Like 4
  • P2Y Purinoceptor 1 3

External Ids for SUCNR1 Gene

Previous HGNC Symbols for SUCNR1 Gene

  • GPR91

Previous GeneCards Identifiers for SUCNR1 Gene

  • GC03P153074
  • GC03P151591
  • GC03P148982

Summaries for SUCNR1 Gene

Entrez Gene Summary for SUCNR1 Gene

  • This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. [provided by RefSeq, Oct 2009]

GeneCards Summary for SUCNR1 Gene

SUCNR1 (Succinate Receptor 1) is a Protein Coding gene. Diseases associated with SUCNR1 include Exudative Vitreoretinopathy 1. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is P2RY1.

UniProtKB/Swiss-Prot for SUCNR1 Gene

  • Receptor for succinate.

Gene Wiki entry for SUCNR1 Gene

Additional gene information for SUCNR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUCNR1 Gene

Genomics for SUCNR1 Gene

Regulatory Elements for SUCNR1 Gene

Enhancers for SUCNR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H151909 0.5 ENCODE 11.7 +36.3 36323 1.5 JUND JUN FOS NFE2 MAFK SUCNR1 AADAC AADACL2-AS1 LOC105374159
GH03H151925 0.8 Ensembl ENCODE 5.2 +53.1 53073 2.3 JUND POLR2A MAX FOS AADAC SUCNR1 AADACL2-AS1 LOC105374159
GH03H151870 1.5 FANTOM5 Ensembl ENCODE 0.7 -2.0 -2043 1.6 HDAC1 ATF1 ZBTB40 CHAMP1 ZNF766 ELK1 ATF7 ETV6 CREM IKZF2 AADAC SUCNR1
GH03H151875 1.5 FANTOM5 Ensembl ENCODE 0.7 +2.7 2700 1.7 HDAC1 PKNOX1 ATF1 TBL1XR1 ARNT ZNF133 ZNF766 GATA2 SIRT6 ATF7 AADAC SUCNR1 LOC105374159
GH03H151864 0.9 Ensembl ENCODE 0.4 -8.9 -8869 0.9 JUN CEBPB CEBPG EP300 BRCA1 RFX5 FOSL1 JUND MAFF ATF3 SUCNR1 AADAC
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SUCNR1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SUCNR1 Gene

Genomic Locations for SUCNR1 Gene
10,977 bases
Plus strand

Genomic View for SUCNR1 Gene

Genes around SUCNR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUCNR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUCNR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUCNR1 Gene

Proteins for SUCNR1 Gene

  • Protein details for SUCNR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Succinate receptor 1
    Protein Accession:
    Secondary Accessions:
    • A8K305
    • Q8TDQ8

    Protein attributes for SUCNR1 Gene

    334 amino acids
    Molecular mass:
    38698 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK29080.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SUCNR1 Gene

Post-translational modifications for SUCNR1 Gene

  • Glycosylation at posLast=88 and Asn168
  • Modification sites at PhosphoSitePlus

Other Protein References for SUCNR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SUCNR1 Gene

Domains & Families for SUCNR1 Gene

Gene Families for SUCNR1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for SUCNR1 Gene

Suggested Antigen Peptide Sequences for SUCNR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with SUCNR1: view

Function for SUCNR1 Gene

Molecular function for SUCNR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for succinate.

Gene Ontology (GO) - Molecular Function for SUCNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with SUCNR1: view
genes like me logo Genes that share phenotypes with SUCNR1: view

Animal Models for SUCNR1 Gene

MGI Knock Outs for SUCNR1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUCNR1 Gene

Localization for SUCNR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUCNR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUCNR1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SUCNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SUCNR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SUCNR1 Gene

Pathways & Interactions for SUCNR1 Gene

genes like me logo Genes that share pathways with SUCNR1: view

Pathways by source for SUCNR1 Gene

Gene Ontology (GO) - Biological Process for SUCNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SUCNR1: view

No data available for SIGNOR curated interactions for SUCNR1 Gene

Drugs & Compounds for SUCNR1 Gene

(3) Drugs for SUCNR1 Gene - From: DrugBank, DGIdb, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinic acid Approved Nutra Full agonist, Agonist, inhibitor, Target 0

(2) Additional Compounds for SUCNR1 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SUCNR1: view

Transcripts for SUCNR1 Gene

mRNA/cDNA for SUCNR1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SUCNR1 Gene

Succinate receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUCNR1 Gene

No ASD Table

Relevant External Links for SUCNR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SUCNR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUCNR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUCNR1 Gene

This gene is overexpressed in Thyroid (x13.3) and Kidney - Cortex (x8.0).

Protein differential expression in normal tissues from HIPED for SUCNR1 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SUCNR1 Gene

Protein tissue co-expression partners for SUCNR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SUCNR1 Gene:


SOURCE GeneReport for Unigene cluster for SUCNR1 Gene:


mRNA Expression by UniProt/SwissProt for SUCNR1 Gene:

Tissue specificity: Expressed specifically in kidney.

Evidence on tissue expression from TISSUES for SUCNR1 Gene

  • Kidney(4.5)
  • Blood(4.3)
genes like me logo Genes that share expression patterns with SUCNR1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SUCNR1 Gene

Orthologs for SUCNR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SUCNR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SUCNR1 33 34
  • 99.1 (n)
(Canis familiaris)
Mammalia SUCNR1 33 34
  • 87.58 (n)
(Bos Taurus)
Mammalia SUCNR1 33 34
  • 83.65 (n)
(Mus musculus)
Mammalia Sucnr1 33 16 34
  • 76.51 (n)
(Rattus norvegicus)
Mammalia Sucnr1 33
  • 76.4 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
-- 34
  • 68 (a)
(Gallus gallus)
Aves SUCNR1 33 34
  • 62.12 (n)
(Anolis carolinensis)
Reptilia SUCNR1 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sucnr1 33
  • 61 (n)
(Danio rerio)
Actinopterygii wisp2 34
  • 29 (a)
Species where no ortholog for SUCNR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUCNR1 Gene

Gene Tree for SUCNR1 (if available)
Gene Tree for SUCNR1 (if available)

Paralogs for SUCNR1 Gene

Paralogs for SUCNR1 Gene

(10) SIMAP similar genes for SUCNR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SUCNR1: view

Variants for SUCNR1 Gene

Sequence variations from dbSNP and Humsavar for SUCNR1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000034320 -- 151,879,511(+) GCAGC(C/T)ACCAT intron-variant
rs1000490987 -- 151,879,787(+) CAATA(A/T)GGAAA intron-variant
rs1001095406 -- 151,878,506(+) AAATG(-/A)AAAAA intron-variant
rs1001127932 -- 151,875,595(+) ATTAA(A/G)ATGTA intron-variant
rs1001160294 -- 151,879,222(+) AGCAA(A/G)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUCNR1 Gene

Variant ID Type Subtype PubMed ID
nsv829758 CNV gain 17160897
nsv4067 CNV insertion 18451855
esv2759189 CNV loss 17122850
dgv8654n54 CNV loss 21841781
dgv622n27 CNV loss 19166990

Variation tolerance for SUCNR1 Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUCNR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUCNR1 Gene

Disorders for SUCNR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SUCNR1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
exudative vitreoretinopathy 1
  • retinopathy of prematurity
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SUCNR1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SUCNR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUCNR1 Gene

Publications for SUCNR1 Gene

  1. Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. (PMID: 15141213) He W … Ling L (Nature 2004) 2 3 4 60
  2. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. (PMID: 11273702) Wittenberger T … Hellebrand S (Journal of molecular biology 2001) 2 3 4 60
  3. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PMID: 17192395) Macaulay IC … Ouwehand WH (Blood 2007) 2 3 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation. (PMID: 28061458) Mu X … You Q (Oncotarget 2017) 3 60

Products for SUCNR1 Gene

Sources for SUCNR1 Gene

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