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Aliases for SUCNR1 Gene

Aliases for SUCNR1 Gene

  • Succinate Receptor 1 2 3 5
  • G Protein-Coupled Receptor 91 2 3
  • G-Protein Coupled Receptor 91 3 4
  • GPR91 3 4
  • P2Y Purinoceptor 1-Like 4
  • P2Y Purinoceptor 1 3

External Ids for SUCNR1 Gene

Previous HGNC Symbols for SUCNR1 Gene

  • GPR91

Previous GeneCards Identifiers for SUCNR1 Gene

  • GC03P153074
  • GC03P151591
  • GC03P148982

Summaries for SUCNR1 Gene

Entrez Gene Summary for SUCNR1 Gene

  • This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. [provided by RefSeq, Oct 2009]

GeneCards Summary for SUCNR1 Gene

SUCNR1 (Succinate Receptor 1) is a Protein Coding gene. Diseases associated with SUCNR1 include exudative vitreoretinopathy 1. Among its related pathways are Signaling by GPCR and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is P2RY2.

UniProtKB/Swiss-Prot for SUCNR1 Gene

  • Receptor for succinate.

Gene Wiki entry for SUCNR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUCNR1 Gene

Genomics for SUCNR1 Gene

Regulatory Elements for SUCNR1 Gene

Promoters for SUCNR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUCNR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUCNR1 Gene

Chromosome:
3
Start:
151,873,643 bp from pter
End:
151,884,619 bp from pter
Size:
10,977 bases
Orientation:
Plus strand

Genomic View for SUCNR1 Gene

Genes around SUCNR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUCNR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUCNR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUCNR1 Gene

Proteins for SUCNR1 Gene

  • Protein details for SUCNR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXA5-SUCR1_HUMAN
    Recommended name:
    Succinate receptor 1
    Protein Accession:
    Q9BXA5
    Secondary Accessions:
    • A8K305
    • Q8TDQ8

    Protein attributes for SUCNR1 Gene

    Size:
    334 amino acids
    Molecular mass:
    38698 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK29080.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SUCNR1 Gene

Proteomics data for SUCNR1 Gene at MOPED

Post-translational modifications for SUCNR1 Gene

  • Glycosylation at Asn 8 and Asn 168
  • Modification sites at PhosphoSitePlus

Other Protein References for SUCNR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SUCNR1 Gene

Domains & Families for SUCNR1 Gene

Gene Families for SUCNR1 Gene

Protein Domains for SUCNR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SUCNR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXA5

UniProtKB/Swiss-Prot:

SUCR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with SUCNR1: view

Function for SUCNR1 Gene

Molecular function for SUCNR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for succinate.
genes like me logo Genes that share phenotypes with SUCNR1: view

Animal Models for SUCNR1 Gene

MGI Knock Outs for SUCNR1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUCNR1 Gene

Localization for SUCNR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUCNR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUCNR1 Gene COMPARTMENTS Subcellular localization image for SUCNR1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SUCNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SUCNR1: view

Pathways & Interactions for SUCNR1 Gene

genes like me logo Genes that share pathways with SUCNR1: view

Pathways by source for SUCNR1 Gene

1 KEGG pathway for SUCNR1 Gene

Interacting Proteins for SUCNR1 Gene

Gene Ontology (GO) - Biological Process for SUCNR1 Gene

None

No data available for SIGNOR curated interactions for SUCNR1 Gene

Drugs & Compounds for SUCNR1 Gene

(3) Drugs for SUCNR1 Gene - From: DGIdb, IUPHAR, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinic acid Approved Nutra Full agonist, Agonist, inhibitor, Target 0
2-{4-[5-(3-CHLORO-4-TRIflUOROMETHOXYPHENYL)-[1,3,4]OXADIAZOL-2-YL]BUTYL}-[1,8]NAPHTHYRIDINE Pharma 0
N-[{3-(3-TRIflUOROMETHYL-4-flUOROPHENYL)ISOXAZOL-5-YL}METHYL]-4-([1,8]NAPHTHYRIDIN-2-YL)BUTYRAMIDE Pharma 0

(2) Additional Compounds for SUCNR1 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-{4-[5-(3-Chloro-4-tri?OEauoromethoxyphenyl)-[1,3,4]oxadiazol-2-yl]butyl}-[1,8]naphthyridine
Antagonist
N-[{3-(3-tri?OEauoromethyl-4-?OEauorophenyl)isoxazol-5-yl}methyl]-4-([1,8]naphthyridin-2-yl)butyramide
Antagonist
genes like me logo Genes that share compounds with SUCNR1: view

Transcripts for SUCNR1 Gene

mRNA/cDNA for SUCNR1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SUCNR1 Gene

Succinate receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUCNR1 Gene

No ASD Table

Relevant External Links for SUCNR1 Gene

GeneLoc Exon Structure for
SUCNR1
ECgene alternative splicing isoforms for
SUCNR1

Expression for SUCNR1 Gene

mRNA expression in normal human tissues for SUCNR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUCNR1 Gene

This gene is overexpressed in Thyroid (x13.3) and Kidney - Cortex (x8.0).

Protein differential expression in normal tissues from HIPED for SUCNR1 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SUCNR1 Gene



SOURCE GeneReport for Unigene cluster for SUCNR1 Gene Hs.279575

mRNA Expression by UniProt/SwissProt for SUCNR1 Gene

Q9BXA5-SUCR1_HUMAN
Tissue specificity: Expressed specifically in kidney.
genes like me logo Genes that share expression patterns with SUCNR1: view

Protein tissue co-expression partners for SUCNR1 Gene

Primer Products

In Situ Assay Products

Orthologs for SUCNR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SUCNR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUCNR1 35
  • 99.1 (n)
  • 98.5 (a)
SUCNR1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUCNR1 36
  • 79 (a)
OneToOne
SUCNR1 35
  • 83.65 (n)
  • 79.43 (a)
dog
(Canis familiaris)
Mammalia SUCNR1 35
  • 87.58 (n)
  • 86.02 (a)
SUCNR1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sucnr1 16
Sucnr1 36
  • 72 (a)
OneToOne
Sucnr1 35
  • 76.51 (n)
  • 72.38 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sucnr1 35
  • 76.4 (n)
  • 74.92 (a)
chicken
(Gallus gallus)
Aves SUCNR1 35
  • 62.12 (n)
  • 60.32 (a)
SUCNR1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUCNR1 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sucnr1 35
  • 61 (n)
  • 60.53 (a)
zebrafish
(Danio rerio)
Actinopterygii wisp2 36
  • 29 (a)
ManyToMany
Species with no ortholog for SUCNR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUCNR1 Gene

ENSEMBL:
Gene Tree for SUCNR1 (if available)
TreeFam:
Gene Tree for SUCNR1 (if available)

Paralogs for SUCNR1 Gene

(10) SIMAP similar genes for SUCNR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SUCNR1: view

Variants for SUCNR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SUCNR1 Gene

Variant ID Type Subtype PubMed ID
dgv1521e1 CNV Complex 17122850
dgv622n27 CNV Loss 19166990
nsv877656 CNV Gain 21882294
nsv829758 CNV Gain 17160897
nsv4067 CNV Insertion 18451855

Variation tolerance for SUCNR1 Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUCNR1 Gene

HapMap Linkage Disequilibrium report
SUCNR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SUCNR1 Gene

Disorders for SUCNR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SUCNR1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
exudative vitreoretinopathy 1
  • retinopathy of prematurity
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SUCNR1

Genetic Association Database (GAD)
SUCNR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUCNR1
genes like me logo Genes that share disorders with SUCNR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUCNR1 Gene

Publications for SUCNR1 Gene

  1. Citric acid cycle intermediates as ligands for orphan G-protein- coupled receptors. (PMID: 15141213) He W. … Ling L. (Nature 2004) 2 3 4 67
  2. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PMID: 17192395) Macaulay I.C. … Ouwehand W.H. (Blood 2007) 2 3 25
  3. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. (PMID: 11273702) Wittenberger T. … Hellebrand S. (J. Mol. Biol. 2001) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions. (PMID: 23833031) Favret S. … Sapieha P. (Aging (Albany NY) 2013) 3

Products for SUCNR1 Gene

Sources for SUCNR1 Gene

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