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Aliases for SUCLG2 Gene

Aliases for SUCLG2 Gene

  • Succinate-CoA Ligase GDP-Forming Beta Subunit 2
  • GTP-Specific Succinyl-CoA Synthetase Subunit Beta 3 4
  • Succinate-CoA Ligase, GDP-Forming, Beta Subunit 3 5
  • Succinyl-CoA Synthetase Beta-G Chain 3 4
  • EC 6.2.1.4 4 63
  • SCS-BetaG 3 4
  • Succinyl-CoA Ligase, GDP-Forming, Beta Chain, Mitochondrial 3
  • GTP-Specific Succinyl-CoA Synthetase Beta Subunit 3
  • Succinyl-CoA Synthetase, Beta-G Chain 3
  • EC 6.2.1 63
  • GBETA 3

External Ids for SUCLG2 Gene

Previous GeneCards Identifiers for SUCLG2 Gene

  • GC03M066056
  • GC03M066888
  • GC03M067249
  • GC03M067507

Summaries for SUCLG2 Gene

Entrez Gene Summary for SUCLG2 Gene

  • This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]

GeneCards Summary for SUCLG2 Gene

SUCLG2 (Succinate-CoA Ligase GDP-Forming Beta Subunit) is a Protein Coding gene. Among its related pathways are Metabolism and Valproic Acid Pathway, Pharmacodynamics. GO annotations related to this gene include protein heterodimerization activity and GDP binding. An important paralog of this gene is SUCLA2.

UniProtKB/Swiss-Prot for SUCLG2 Gene

  • Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUCLG2 Gene

Genomics for SUCLG2 Gene

Regulatory Elements for SUCLG2 Gene

Promoters for SUCLG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUCLG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUCLG2 Gene

Chromosome:
3
Start:
67,360,460 bp from pter
End:
67,654,614 bp from pter
Size:
294,155 bases
Orientation:
Minus strand

Genomic View for SUCLG2 Gene

Genes around SUCLG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUCLG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUCLG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUCLG2 Gene

Proteins for SUCLG2 Gene

  • Protein details for SUCLG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96I99-SUCB2_HUMAN
    Recommended name:
    Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
    Protein Accession:
    Q96I99
    Secondary Accessions:
    • C9JVT2
    • O95195
    • Q6NUH7
    • Q86VX8
    • Q8WUQ1

    Protein attributes for SUCLG2 Gene

    Size:
    432 amino acids
    Molecular mass:
    46511 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit.
    SequenceCaution:
    • Sequence=AAH07716.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH47024.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH47024.1; Type=Erroneous termination; Positions=31; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for SUCLG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUCLG2 Gene

Proteomics data for SUCLG2 Gene at MOPED

Post-translational modifications for SUCLG2 Gene

  • Ubiquitination at Lys 118
  • Modification sites at PhosphoSitePlus

Other Protein References for SUCLG2 Gene

Antibody Products

Domains & Families for SUCLG2 Gene

Suggested Antigen Peptide Sequences for SUCLG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96I99

UniProtKB/Swiss-Prot:

SUCB2_HUMAN :
  • Contains 1 ATP-grasp domain.
  • Belongs to the succinate/malate CoA ligase beta subunit family.
Domain:
  • Contains 1 ATP-grasp domain.
Family:
  • Belongs to the succinate/malate CoA ligase beta subunit family.
genes like me logo Genes that share domains with SUCLG2: view

No data available for Gene Families for SUCLG2 Gene

Function for SUCLG2 Gene

Molecular function for SUCLG2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GTP + succinate + CoA = GDP + phosphate + succinyl-CoA.
UniProtKB/Swiss-Prot Function:
Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA.

Enzyme Numbers (IUBMB) for SUCLG2 Gene

genes like me logo Genes that share phenotypes with SUCLG2: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUCLG2 Gene

Localization for SUCLG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUCLG2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUCLG2 Gene COMPARTMENTS Subcellular localization image for SUCLG2 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
plasma membrane 5
cytosol 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SUCLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with SUCLG2: view

Pathways & Interactions for SUCLG2 Gene

genes like me logo Genes that share pathways with SUCLG2: view

UniProtKB/Swiss-Prot Q96I99-SUCB2_HUMAN

  • Pathway: Carbohydrate metabolism; tricarboxylic acid cycle.

Gene Ontology (GO) - Biological Process for SUCLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006104 succinyl-CoA metabolic process NAS 9765291
GO:0044237 cellular metabolic process TAS --
genes like me logo Genes that share ontologies with SUCLG2: view

No data available for SIGNOR curated interactions for SUCLG2 Gene

Drugs & Compounds for SUCLG2 Gene

(5) Drugs for SUCLG2 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinic acid Approved Nutra Full agonist, Agonist, Target 0
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Succinyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(6) Additional Compounds for SUCLG2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
IDP
  • 5'-IDP
  • IDP
  • Inosine 5'-(trihydrogen diphosphate)
  • Inosine 5'-(trihydrogen pyrophosphate)
  • Inosine 5'-diphosphate
86-04-4
inosine triphosphate
  • 2'-Inosine-5'-triphosphate
  • 5'-ITP
  • 5-ITP
  • Inosine 5
  • Inosine 5'-(tetrahydrogen triphosphate)
132-06-9
Itaconic acid
  • Methylenebutanedioate
  • 2-Hydroxy-3-Naphthoyl-2-Naphthylamine
  • 2-Methylenesuccinate
  • 2-Methylenesuccinic acid
  • 2-Propene-1,2-dicarboxylate
97-65-4
Itaconyl-CoA
  • Itaconoyl CoA
  • Itaconoyl coenzyme A
  • S-(1-Hydrogen methylenesuccinate) CoA
  • S-(1-Hydrogen methylenesuccinate) Coenzyme A
  • S-3-Methylenesuccinate CoA
6008-93-1
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with SUCLG2: view

Transcripts for SUCLG2 Gene

Unigene Clusters for SUCLG2 Gene

Succinate-CoA ligase, GDP-forming, beta subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUCLG2 Gene

No ASD Table

Relevant External Links for SUCLG2 Gene

GeneLoc Exon Structure for
SUCLG2
ECgene alternative splicing isoforms for
SUCLG2

Expression for SUCLG2 Gene

mRNA expression in normal human tissues for SUCLG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUCLG2 Gene

This gene is overexpressed in Liver (x5.0).

Protein differential expression in normal tissues from HIPED for SUCLG2 Gene

This gene is overexpressed in Nasal epithelium (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUCLG2 Gene



SOURCE GeneReport for Unigene cluster for SUCLG2 Gene Hs.644919

mRNA Expression by UniProt/SwissProt for SUCLG2 Gene

Q96I99-SUCB2_HUMAN
Tissue specificity: Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and colon, and in low amounts in lung, brain, prostate, testis and ovary.
genes like me logo Genes that share expression patterns with SUCLG2: view

Protein tissue co-expression partners for SUCLG2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SUCLG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUCLG2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUCLG2 35
  • 93.17 (n)
  • 94.52 (a)
SUCLG2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUCLG2 35
  • 91.67 (n)
  • 92.59 (a)
SUCLG2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Suclg2 35
  • 88.23 (n)
  • 93.08 (a)
Suclg2 16
Suclg2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUCLG2 35
  • 99.61 (n)
  • 99.54 (a)
rat
(Rattus norvegicus)
Mammalia Suclg2 35
  • 88.33 (n)
  • 92.14 (a)
oppossum
(Monodelphis domestica)
Mammalia SUCLG2 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUCLG2 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUCLG2 35
  • 79.44 (n)
  • 86.67 (a)
SUCLG2 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUCLG2 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1992 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5442 35
zebrafish
(Danio rerio)
Actinopterygii suclg2 35
  • 73.75 (n)
  • 81.86 (a)
wufb64e03 35
suclg2 36
  • 49 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004352 35
  • 59.22 (n)
  • 59.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sucb 35
  • 59.91 (n)
  • 59.22 (a)
Sucb 36
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sucg-1 35
  • 60.03 (n)
  • 54.91 (a)
sucg-1 36
  • 51 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSC2 36
  • 42 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1791 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.212 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.911 36
  • 59 (a)
OneToOne
Species with no ortholog for SUCLG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUCLG2 Gene

ENSEMBL:
Gene Tree for SUCLG2 (if available)
TreeFam:
Gene Tree for SUCLG2 (if available)

Paralogs for SUCLG2 Gene

Paralogs for SUCLG2 Gene

(4) SIMAP similar genes for SUCLG2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SUCLG2 Gene

genes like me logo Genes that share paralogs with SUCLG2: view

Variants for SUCLG2 Gene

Sequence variations from dbSNP and Humsavar for SUCLG2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs9843840 - 67,495,820(+) GCAAT(C/T)TGAAT nc-transcript-variant, reference, missense
rs7623258 - 67,400,773(+) CTCCC(A/G)GCAGG nc-transcript-variant, reference, missense
rs902320 -- 67,360,679(+) GGCGA(C/T)GTTCT reference, missense
rs902321 -- 67,360,742(+) CATAT(A/G)ACTTC reference, missense
rs727946 -- 67,613,722(-) CTTTA(C/T)TGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUCLG2 Gene

Variant ID Type Subtype PubMed ID
nsv470638 CNV Loss 18288195
nsv460700 CNV Loss 19166990
nsv834719 CNV Gain 17160897
nsv519439 CNV Loss 19592680
nsv508221 CNV Loss 20534489
esv2670594 CNV Deletion 23128226
esv2479752 CNV Deletion 19546169
nsv3860 CNV Loss 18451855
nsv435769 CNV Deletion 17901297
esv2201325 CNV Deletion 18987734
esv2725376 CNV Deletion 23290073
esv1009299 CNV Deletion 20482838
nsv513049 CNV Loss 21212237
esv8929 CNV Loss 19470904
esv1366353 CNV Deletion 17803354
esv8455 CNV Gain 19470904
esv27977 CNV Loss 19812545
esv2660821 CNV Deletion 23128226
esv274522 CNV Insertion 20981092
esv2665141 CNV Deletion 23128226
nsv508222 CNV Loss 20534489
esv275108 CNV Gain+Loss 21479260
nsv876922 CNV Loss 21882294
esv2725377 CNV Deletion 23290073
esv273714 CNV Insertion 20981092

Variation tolerance for SUCLG2 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.60; 91.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUCLG2 Gene

HapMap Linkage Disequilibrium report
SUCLG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUCLG2 Gene

Disorders for SUCLG2 Gene

Relevant External Links for SUCLG2

Genetic Association Database (GAD)
SUCLG2
Human Genome Epidemiology (HuGE) Navigator
SUCLG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUCLG2

No disorders were found for SUCLG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUCLG2 Gene

Publications for SUCLG2 Gene

  1. Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. (PMID: 9765291) Johnson J.D. … Lambeth D.O. (J. Biol. Chem. 1998) 2 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SUCLG2 Gene

Sources for SUCLG2 Gene

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