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SUCLG2 Gene

protein-coding   GIFtS: 62
GCID: GC03M067507

Succinate-CoA Ligase, GDP-Forming, Beta Subunit

  See SUCLG2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Succinate-CoA Ligase, GDP-Forming, Beta Subunit1 2     GTP-Specific Succinyl-CoA Synthetase Beta Subunit2
Succinyl-CoA Synthetase Beta-G Chain2 3     Succinyl-CoA Ligase [GDP-Forming] Subunit Beta, Mitochondrial2
SCS-betaG2 3     Succinyl-CoA Ligase, GDP-Forming, Beta Chain, Mitochondrial2
GTP-Specific Succinyl-CoA Synthetase Subunit Beta2 3     Succinyl-CoA Synthetase, Beta-G Chain2
EC 6.2.1.43 8     EC 6.2.18
GBETA2     

External Ids:    HGNC: 114501   Entrez Gene: 88012   Ensembl: ENSG000001723407   OMIM: 6039225   UniProtKB: Q96I993   

Export aliases for SUCLG2 gene to outside databases

Previous GC identifers: GC03M066056 GC03M066888 GC03M067249 GC03M067358


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SUCLG2 Gene:
This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the
reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple
transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. (provided by RefSeq, Apr 2010)

GeneCards Summary for SUCLG2 Gene:
SUCLG2 (succinate-CoA ligase, GDP-forming, beta subunit) is a protein-coding gene. Diseases associated with SUCLG2 include pharyngitis. GO annotations related to this gene include succinate-CoA ligase (GDP-forming) activity and GTP binding. An important paralog of this gene is SUCLA2.

UniProtKB/Swiss-Prot: SUCB2_HUMAN, Q96I99
Function: Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUCLG2 gene promoter:
         ISGF-3   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Evi-1   CREB   IRF-2   Nkx6-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUCLG2 promoter sequence
   Search Chromatin IP Primers for SUCLG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUCLG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.1   Ensembl cytogenetic band:  3p14.1   HGNC cytogenetic band: 3p14.3

SUCLG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUCLG2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M067507:  view genomic region     (about GC identifiers)

Start:
67,410,884 bp from pter      End:
67,705,038 bp from pter
Size:
294,155 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SUCB2_HUMAN, Q96I99 (See protein sequence)
Recommended Name: Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial precursor  
Size: 432 amino acids; 46511 Da
Subunit: Heterodimer of an alpha and a beta subunit
Sequence caution: Sequence=AAH07716.3; Type=Erroneous initiation; Sequence=AAH47024.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=AAH47024.1; Type=Erroneous termination; Positions=31;
Note=Translated as Gln;
Secondary accessions: C9JVT2 O95195 Q6NUH7 Q86VX8 Q8WUQ1
Alternative splicing: 2 isoforms:  Q96I99-1   Q96I99-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SUCLG2: NX_Q96I99

Explore proteomics data for SUCLG2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys118
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SUCLG2 (Q96I99) (see all 13)
     DAKINFD  VNIFGGI  VPLVVRL  SGLKGGV 


    See SUCLG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171070.1  NP_003839.2  

    ENSEMBL proteins: 
     ENSP00000419325   ENSP00000417260   ENSP00000307432   ENSP00000417589  
    Reactome Protein details: Q96I99

    SUCLG2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SUCLG2
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    Novus Biologicals SUCLG2 Protein
    Novus Biologicals SUCLG2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SUCLG2

     
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    Cloud-Clone Corp. ELISAs for SUCLG2
    Cloud-Clone Corp. CLIAs for SUCLG2
    Search eBioscience for ELISAs for SUCLG2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR005809 Succ_CoA_synthase_bsu
     IPR017866 Succ-CoA_synthase_bsu_CS
     IPR013650 ATP-grasp_succ-CoA_synth-type
     IPR013815 ATP_grasp_subdomain_1
     IPR005811 CoA_ligase

    Graphical View of Domain Structure for InterPro Entry Q96I99

    ProtoNet protein and cluster: Q96I99

    2 Blocks protein domains:
    IPB005809 Succinyl-CoA synthetase
    IPB013650 ATP-grasp fold


    UniProtKB/Swiss-Prot: SUCB2_HUMAN, Q96I99
    Similarity: Belongs to the succinate/malate CoA ligase beta subunit family
    Similarity: Contains 1 ATP-grasp domain


    Find genes that share domains with SUCLG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUCB2_HUMAN, Q96I99
    Function: Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity)
    Catalytic activity: GTP + succinate + CoA = GDP + phosphate + succinyl-CoA

         Enzyme Numbers (IUBMB): EC 6.2.1.41 2 EC 6.2.12

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004776succinate-CoA ligase (GDP-forming) activity NAS9765291
    GO:0005524ATP binding IEA--
    GO:0005525GTP binding IEA--
    GO:0019003GDP binding IEA--
         
    Find genes that share ontologies with SUCLG2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SUCLG2:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SUCLG2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUCLG2
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    miRNA
    Products:
        
    miRTarBase miRNAs that target SUCLG2:
    hsa-mir-92a-3p (MIRT049822), hsa-mir-124-3p (MIRT001830)

    Block miRNA regulation of human, mouse, rat SUCLG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SUCLG2 (see all 24):
    hsa-miR-30c hsa-miR-3910 hsa-miR-16-2* hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-30d hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidSUCLG2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SUCLG2
    Predesigned siRNA for gene silencing in human, mouse, rat SUCLG2

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for SUCLG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SUCLG2 (NM_003848)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUCLG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUCLG2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SUCLG2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUCLG2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SUCB2_HUMAN, Q96I99: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    plasma membrane3
    cytoskeleton2
    cytosol2
    endosome1
    extracellular1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix TAS--
    GO:0005886plasma membrane IDA--
    GO:0043234protein complex ----
    GO:0045244succinate-CoA ligase complex (GDP-forming) IEA--

    Find genes that share ontologies with SUCLG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SUCLG2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Citric acid cycle (TCA cycle)
    Citric acid cycle (TCA cycle)0.55
    conversion of glucose to acetyl CoA and entry into the TCA cycle0.43
    Citrate cycle (TCA cycle)0.55
    TCA Cycle0.00
    Pyruvate metabolism and Citric Acid (TCA) cycle0.49
    TCA cycle0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport0.71
    4Carbon metabolism
    Carbon metabolism0.38
    5Valine, leucine and isoleucine degradation
    Propanoate metabolism0.31


    Find genes that share SuperPaths with SUCLG2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for SUCLG2
        TCA Cycle
    TCA cycle
    conversion of glucose to acetyl CoA and entry into the TCA cycle

    1 Reactome Pathway for SUCLG2
        Citric acid cycle (TCA cycle)

    1 PharmGKB Pathway for SUCLG2
        Valproic Acid Pathway, Pharmacodynamics

    4 Kegg Pathways  (Kegg details for SUCLG2):
        Citrate cycle (TCA cycle)
    Propanoate metabolism
    Metabolic pathways
    Carbon metabolism

    UniProtKB/Swiss-Prot: SUCB2_HUMAN, Q96I99
    Pathway: Carbohydrate metabolism; tricarboxylic acid cycle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SUCLG2: 

              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SUCLG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SUCLG2 (Q96I993 ENSP000003074324) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    USP19O949663, ENSP000003818634I2D: score=2 STRING: ENSP00000381863
    DMWDQ090193, ENSP000002702234I2D: score=2 STRING: ENSP00000270223
    GPR143P518103, ENSP000003703164I2D: score=1 STRING: ENSP00000370316
    SUCLG1P535973, ENSP000003774464I2D: score=1 STRING: ENSP00000377446
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006099tricarboxylic acid cycle TAS--
    GO:0006104succinyl-CoA metabolic process NAS9765291
    GO:0006105succinate metabolic process IEA--
    GO:0008152metabolic process ----
    GO:0044237cellular metabolic process TAS--

    Find genes that share ontologies with SUCLG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SUCLG2 (SUCB2)

    10 HMDB Compounds for SUCLG2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    IDP5'-IDP (see all 10)86-04-4--
    Inosine triphosphateinosine 5'-(tetrahydrogen triphosphate) (see all 13)132-06-9--
    Itaconic acid2-Hydroxy-3-Naphthoyl-2-Naphthylamine (see all 12)97-65-4--
    Itaconyl-CoAS-(1-hydrogen methylenesuccinate) Coenzyme A (see all 8)6008-93-1--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Succinic acid1,2-Ethanedicarboxylate (see all 11)110-15-6--
    Succinyl-CoACoenzyme A S-(hydrogen succinate) (see all 24)604-98-8--

    1 DrugBank Compound for SUCLG2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Succinic acid1,2-Ethanedicarboxylic acid (see all 8)110-15-6target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SUCLG2 gene (2 alternative transcripts): 
    NM_001177599.1  NM_003848.3  

    Unigene Cluster for SUCLG2:

    Succinate-CoA ligase, GDP-forming, beta subunit
    Hs.644919  [show with all ESTs]
    Unigene Representative Sequence: BC068602
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493112(uc021xae.1) ENST00000460567(uc010hob.3) ENST00000307227(uc003dna.4)
    ENST00000492795
    miRNA
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    Block miRNA regulation of human, mouse, rat SUCLG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SUCLG2 (see all 24):
    hsa-miR-30c hsa-miR-3910 hsa-miR-16-2* hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-30d hsa-let-7g
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    Predesigned siRNA for gene silencing in human, mouse, rat SUCLG2
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SUCLG2 (NM_003848)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SUCLG2
      QuantiTect SYBR Green Assays in human, mouse, rat SUCLG2
      QuantiFast Probe-based Assays in human, mouse, rat SUCLG2

    Additional mRNA sequence: 

    AF058954.1 AF131748.1 AK294598.1 AK310527.1 AL050226.1 BC007716.2 BC019868.1 BC035149.1 
    BC047024.1 BC068602.1 

    5 DOTS entries:

    DT.97773778  DT.216109  DT.97796010  DT.95292139  DT.100788201 

    Selected AceView cDNA sequences (see all 219):

    BX282340 BI089794 AI478637 AW078487 T32341 AA777335 BM993899 BM983527 
    AL050226 BM547459 CN479434 CA428963 AI572877 BU681960 AI474658 BF594275 
    BX461233 AW152457 AV650276 AA346109 AV660709 BQ440436 CK724886 BQ949231 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SUCLG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTCCAATT
    SUCLG2 Expression
    About this image


    SUCLG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
             Thymus
     
     Kidney (Urinary System)
             Metanephros
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
     
     Eye (Sensory Organs)
             Lens
    SUCLG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUCLG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.644919

    UniProtKB/Swiss-Prot: SUCB2_HUMAN, Q96I99
    Tissue specificity: Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine
    and colon, and in low amounts in lung, brain, prostate, testis and ovary

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SUCLG2: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SUCLG2
    OriGene qSTAR qPCR primer pairs in human, mouse for SUCLG2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SUCLG2
    QuantiTect SYBR Green Assays in human, mouse, rat SUCLG2
    QuantiFast Probe-based Assays in human, mouse, rat SUCLG2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUCLG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUCLG2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Suclg21 , 5 succinate-Coenzyme A ligase, GDP-forming, beta subunit1, 5 88.23(n)1
    93.08(a)1
      6 (44.63 cM)5
    209171  NM_011507.21  NP_035637.21 
     954741345 
    chicken
    (Gallus gallus)
    Aves SUCLG21 succinate-CoA ligase, GDP-forming, beta subunit 79.44(n)
    86.67(a)
      416087  NM_001006141.1  NP_001006141.1 
    lizard
    (Anolis carolinensis)
    Reptilia SUCLG26
    succinate-CoA ligase, GDP-forming, beta subunit
    81(a)
    1 ↔ 1
    2(183640094-183908668)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.54422 Xenopus laevis transcribed sequence with weak similarity more 78.1(n)    BQ731661.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb64e032 Danio rerio cDNA clone IMAGE6794135, partial cds 78.06(n)    BC056551.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sucb1 Sucb 59.91(n)
    59.22(a)
      44001  NM_143706.4  NP_651963.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sucg-11 sucg-1 60.03(n)
    54.91(a)
      177555  NM_068865.4  NP_501266.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LSC26
    Beta subunit of succinyl-CoA ligase, which is a mi...
    42(a)
    1 → many
    VII(978036-979319) YGR244C
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.17912 Vitis vinifera transcribed sequence with moderate similarity more 75.54(n)    CB971953.1 


    ENSEMBL Gene Tree for SUCLG2 (if available)
    TreeFam Gene Tree for SUCLG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SUCLG2 gene
    SUCLA22  
    4 SIMAP similar genes for SUCLG2 using alignment to 4 protein entries:     SUCB2_HUMAN (see all proteins):
    DKFZp564P2062    SUCLA2    DKFZp686D0880    DKFZp586M2023

    Find genes that share paralogs with SUCLG2           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for SUCLG2
    PGOHUM00000242466 PGOHUM00000239896 PGOHUM00000237799 PGOHUM00000235537


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SUCLG2 (see all 6655)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1915247481,2
    --67410387(+) AACCAA/GCCCTA 1 -- ds50010--------
    rs1829450151,2
    --67410398(+) GAACCA/GCCCTA 1 -- ds50010--------
    rs1853665621,2
    --67410455(+) TAGCTC/TTTATA 1 -- ds50010--------
    rs1901195781,2
    --67410498(+) CTAACA/GGATAT 1 -- ds50010--------
    rs799623131,2
    C--67410541(+) TATAAA/GCAGAT 1 -- ds50014Minor allele frequency- G:0.18CSA WA NA EA 360
    rs1456466841,2
    --67410579(+) ACTGGA/CGTGGA 1 -- ds50010--------
    rs1381859241,2
    --67410588(+) GAATAA/CTCTGA 1 -- ds50010--------
    rs1426152811,2
    C--67410650(+) AGGCT-/GGGTTAT 1 -- ds50010--------
    rs1820744681,2
    --67410654(+) CTGTTA/TTATAG 1 -- ds50010--------
    rs763644671,2
    C,F--67410700(+) AGGAGG/AATTAA 1 -- ds50011Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for SUCLG2 (67410884 - 67660884 bp, first 250kb of SUCLG2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SUCLG2 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665141CNV Deletion23128226
    esv2479752CNV Deletion19546169
    esv1009299CNV Deletion20482838
    esv2725376CNV Deletion23290073
    esv2670594CNV Deletion23128226
    esv2660821CNV Deletion23128226
    esv2201325CNV Deletion18987734
    esv1366353CNV Deletion17803354
    esv2725377CNV Deletion23290073
    nsv435769CNV Deletion17901297

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SUCLG2
    DNA2.0 Custom Variant and Variant Library Synthesis for SUCLG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603922    OMIM disorders: --

    1 disease for SUCLG2:    
    About MalaCards
    pharyngitis

    2 diseases from the University of Copenhagen DISEASES database for SUCLG2:
    Cholera     Pharyngitis

    Find genes that share disorders with SUCLG2           About GenesLikeMe

    Genetic Association Database (GAD): SUCLG2
    Human Genome Epidemiology (HuGE) Navigator: SUCLG2 (5 documents)

    Export disorders for SUCLG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUCLG2 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with SUCLG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. (PubMed id 9765291)1, 2, 3 Johnson J.D.... Lambeth D.O. (J. Biol. Chem. 1998)
    2. Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. (PubMed id 22144915)1, 4 Fan Q....Saw S.M. (PLoS Genet. 2011)
    3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. (PubMed id 23146381)1 Levin A.M....Williams L.K. (J. Allergy Clin. Immunol. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8801 HGNC: 11450 AceView: SUCLG2 Ensembl:ENSG00000172340 euGenes: HUgn8801
    ECgene: SUCLG2 Kegg: 8801 H-InvDB: SUCLG2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SUCLG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SUCLG2 gene:
    Search GeneIP for patents involving SUCLG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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