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Aliases for SUCLG2 Gene

Aliases for SUCLG2 Gene

  • Succinate-CoA Ligase GDP-Forming Beta Subunit 2 3 5
  • GTP-Specific Succinyl-CoA Synthetase Subunit Beta 3 4
  • EC 6.2.1.4 4 61
  • SCS-BetaG 3 4
  • GTPSCS 3 4
  • G-SCS 3 4
  • Succinate--CoA Ligase [GDP-Forming] Subunit Beta, Mitochondrial 3
  • Succinyl-CoA Ligase [GDP-Forming] Subunit Beta, Mitochondrial 3
  • Succinyl-CoA Ligase, GDP-Forming, Beta Chain, Mitochondrial 3
  • GTP-Specific Succinyl-CoA Synthetase Beta Subunit 3
  • Succinyl-CoA Synthetase, Beta-G Chain 3
  • Succinyl-CoA Synthetase Beta-G Chain 4
  • EC 6.2.1 61
  • GBETA 3

External Ids for SUCLG2 Gene

Previous GeneCards Identifiers for SUCLG2 Gene

  • GC03M066056
  • GC03M066888
  • GC03M067249
  • GC03M067507

Summaries for SUCLG2 Gene

Entrez Gene Summary for SUCLG2 Gene

  • This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]

GeneCards Summary for SUCLG2 Gene

SUCLG2 (Succinate-CoA Ligase GDP-Forming Beta Subunit) is a Protein Coding gene. Among its related pathways are Metabolism and Citrate cycle (TCA cycle). GO annotations related to this gene include protein heterodimerization activity and GDP binding. An important paralog of this gene is SUCLA2.

UniProtKB/Swiss-Prot for SUCLG2 Gene

  • GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUCLG2 Gene

Genomics for SUCLG2 Gene

Regulatory Elements for SUCLG2 Gene

Enhancers for SUCLG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F067296 0.2 ENCODE 10.6 +357.7 357673 0.8 SOX13 SSRP1 DMAP1 MAFK ZKSCAN1 SUCLG2 ENSG00000241884 GC03M067321
GH03F067290 0.5 Ensembl 6.3 +364.2 364213 0.4 IKZF1 SPI1 SUCLG2 ENSG00000241884 MIR4272
GH03F067646 1.1 Ensembl ENCODE 5.1 +5.7 5725 5.5 ATF1 ARID4B SIN3A DMAP1 YY1 FOS SP5 MIER2 PPARG KAT8 SUCLG2-AS1 SUCLG2 GC03P067630
GH03F067685 0.5 Ensembl ENCODE 4.3 -31.1 -31140 1.4 MTA2 IKZF1 JUNB TBX21 SPI1 SUCLG2 GC03P067687 SUCLG2-AS1
GH03F067461 0.7 Ensembl ENCODE 4.3 +192.4 192373 1.7 JUND SMARCA4 GLIS1 JUN SUCLG2-AS1 SUCLG2 NDUFB4P1 GC03M067398
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SUCLG2 on UCSC Golden Path with GeneCards custom track

Promoters for SUCLG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001366614 114 3001 HDGF MLX ZFP64 SIN3A DMAP1 ZNF48 YY1 SLC30A9 GLIS2 CBX5

Genomic Location for SUCLG2 Gene

Chromosome:
3
Start:
67,360,460 bp from pter
End:
67,654,614 bp from pter
Size:
294,155 bases
Orientation:
Minus strand

Genomic View for SUCLG2 Gene

Genes around SUCLG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUCLG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUCLG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUCLG2 Gene

Proteins for SUCLG2 Gene

  • Protein details for SUCLG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96I99-SUCB2_HUMAN
    Recommended name:
    Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
    Protein Accession:
    Q96I99
    Secondary Accessions:
    • C9JVT2
    • O95195
    • Q6NUH7
    • Q86VX8
    • Q8WUQ1

    Protein attributes for SUCLG2 Gene

    Size:
    432 amino acids
    Molecular mass:
    46511 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
    SequenceCaution:
    • Sequence=AAH07716.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH47024.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH47024.1; Type=Erroneous termination; Positions=31; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for SUCLG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUCLG2 Gene

Post-translational modifications for SUCLG2 Gene

  • Ubiquitination at Lys 118
  • Modification sites at PhosphoSitePlus

Domains & Families for SUCLG2 Gene

Suggested Antigen Peptide Sequences for SUCLG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96I99

UniProtKB/Swiss-Prot:

SUCB2_HUMAN :
  • Contains 1 ATP-grasp domain.
  • Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
Domain:
  • Contains 1 ATP-grasp domain.
Family:
  • Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
genes like me logo Genes that share domains with SUCLG2: view

No data available for Gene Families for SUCLG2 Gene

Function for SUCLG2 Gene

Molecular function for SUCLG2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GTP + succinate + CoA = GDP + phosphate + succinyl-CoA.
UniProtKB/Swiss-Prot Function:
GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Enzyme Numbers (IUBMB) for SUCLG2 Gene

Gene Ontology (GO) - Molecular Function for SUCLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004776 succinate-CoA ligase (GDP-forming) activity NAS 9765291
GO:0005524 ATP binding IEA --
GO:0005525 GTP binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with SUCLG2: view
genes like me logo Genes that share phenotypes with SUCLG2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SUCLG2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUCLG2 Gene

Localization for SUCLG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUCLG2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUCLG2 Gene COMPARTMENTS Subcellular localization image for SUCLG2 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
plasma membrane 5
cytosol 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SUCLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix TAS --
GO:0005815 microtubule organizing center IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with SUCLG2: view

Pathways & Interactions for SUCLG2 Gene

genes like me logo Genes that share pathways with SUCLG2: view

UniProtKB/Swiss-Prot Q96I99-SUCB2_HUMAN

  • Pathway: Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Gene Ontology (GO) - Biological Process for SUCLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006099 tricarboxylic acid cycle TAS --
GO:0006104 succinyl-CoA metabolic process NAS 9765291
GO:0006105 succinate metabolic process IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with SUCLG2: view

No data available for SIGNOR curated interactions for SUCLG2 Gene

Drugs & Compounds for SUCLG2 Gene

(6) Drugs for SUCLG2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinic acid Approved Nutra Full agonist, Agonist, Target 0
Phosphoric acid Approved Pharma 0
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Succinyl-CoA Experimental Pharma 0

(5) Additional Compounds for SUCLG2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
IDP
  • 5'-IDP
  • IDP
  • Inosine 5'-(trihydrogen diphosphate)
  • Inosine 5'-(trihydrogen pyrophosphate)
  • Inosine 5'-diphosphate
86-04-4
inosine triphosphate
  • 2'-Inosine-5'-triphosphate
  • 5'-ITP
  • 5-ITP
  • Inosine 5
  • Inosine 5'-(tetrahydrogen triphosphate)
132-06-9
Itaconic acid
  • Methylenebutanedioate
  • 2-Hydroxy-3-Naphthoyl-2-Naphthylamine
  • 2-Methylenesuccinate
  • 2-Methylenesuccinic acid
  • 2-Propene-1,2-dicarboxylate
97-65-4
Itaconyl-CoA
  • Itaconoyl CoA
  • Itaconoyl coenzyme A
  • S-(1-Hydrogen methylenesuccinate) CoA
  • S-(1-Hydrogen methylenesuccinate) Coenzyme A
  • S-3-Methylenesuccinate CoA
6008-93-1
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with SUCLG2: view

Transcripts for SUCLG2 Gene

Unigene Clusters for SUCLG2 Gene

Succinate-CoA ligase, GDP-forming, beta subunit:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUCLG2 Gene

No ASD Table

Relevant External Links for SUCLG2 Gene

GeneLoc Exon Structure for
SUCLG2
ECgene alternative splicing isoforms for
SUCLG2

Expression for SUCLG2 Gene

mRNA expression in normal human tissues for SUCLG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUCLG2 Gene

This gene is overexpressed in Liver (x5.0).

Protein differential expression in normal tissues from HIPED for SUCLG2 Gene

This gene is overexpressed in Nasal epithelium (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUCLG2 Gene



Protein tissue co-expression partners for SUCLG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SUCLG2 Gene:

SUCLG2

SOURCE GeneReport for Unigene cluster for SUCLG2 Gene:

Hs.644919

mRNA Expression by UniProt/SwissProt for SUCLG2 Gene:

Q96I99-SUCB2_HUMAN
Tissue specificity: Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and colon, and in low amounts in lung, brain, prostate, testis and ovary.
genes like me logo Genes that share expression patterns with SUCLG2: view

Primer Products

Orthologs for SUCLG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUCLG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUCLG2 34
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia SUCLG2 34 35
  • 93.17 (n)
dog
(Canis familiaris)
Mammalia SUCLG2 34 35
  • 91.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SUCLG2 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Suclg2 34
  • 88.33 (n)
mouse
(Mus musculus)
Mammalia Suclg2 34 16 35
  • 88.23 (n)
oppossum
(Monodelphis domestica)
Mammalia SUCLG2 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUCLG2 34 35
  • 79.44 (n)
lizard
(Anolis carolinensis)
Reptilia SUCLG2 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1992 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5442 34
zebrafish
(Danio rerio)
Actinopterygii suclg2 34 35
  • 73.75 (n)
wufb64e03 34
fruit fly
(Drosophila melanogaster)
Insecta Sucb 34 35
  • 59.91 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004352 34
  • 59.22 (n)
worm
(Caenorhabditis elegans)
Secernentea sucg-1 34 35
  • 60.03 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSC2 35
  • 42 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1791 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.911 35
  • 59 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.212 34
Species where no ortholog for SUCLG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUCLG2 Gene

ENSEMBL:
Gene Tree for SUCLG2 (if available)
TreeFam:
Gene Tree for SUCLG2 (if available)

Paralogs for SUCLG2 Gene

Paralogs for SUCLG2 Gene

(4) SIMAP similar genes for SUCLG2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SUCLG2 Gene

genes like me logo Genes that share paralogs with SUCLG2: view

Variants for SUCLG2 Gene

Sequence variations from dbSNP and Humsavar for SUCLG2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs150352166 Benign 67,498,303(+) AAATA(-/AAG)AAGAA intron-variant
rs2290174 Benign 67,609,616(+) GGAGA(A/G)AGGTA intron-variant
rs74675534 Benign 67,529,111(+) CTCCT(C/T)TCAAA nc-transcript-variant, reference, missense
rs7623258 Benign 67,400,773(+) CTCCC(A/G)GCAGG nc-transcript-variant, reference, missense
rs902320 Benign 67,360,679(+) GGCGA(C/T)GTTCT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SUCLG2 Gene

Variant ID Type Subtype PubMed ID
dgv126n73 CNV deletion 24416366
dgv1384e212 CNV loss 25503493
dgv2530n106 CNV deletion 24896259
esv1009299 CNV deletion 20482838
esv1366353 CNV deletion 17803354
esv2201325 CNV deletion 18987734
esv2479752 CNV deletion 19546169
esv2660821 CNV deletion 23128226
esv2665141 CNV deletion 23128226
esv2670594 CNV deletion 23128226
esv2725376 CNV deletion 23290073
esv2725377 CNV deletion 23290073
esv275108 CNV gain+loss 21479260
esv27977 CNV loss 19812545
esv2836569 CNV deletion 24192839
esv3309442 CNV mobile element insertion 20981092
esv3384382 CNV insertion 20981092
esv3411680 CNV insertion 20981092
esv3452138 CNV insertion 20981092
esv3562020 CNV deletion 23714750
esv3596456 CNV loss 21293372
esv3596457 CNV loss 21293372
esv3596458 CNV loss 21293372
esv3596459 CNV loss 21293372
esv3596460 CNV loss 21293372
esv3596461 CNV loss 21293372
esv3596462 CNV loss 21293372
esv8455 CNV gain 19470904
esv8929 CNV loss 19470904
nsv1003158 CNV loss 25217958
nsv1012416 CNV gain 25217958
nsv1073228 CNV deletion 25765185
nsv1073229 CNV deletion 25765185
nsv3860 CNV deletion 18451855
nsv435769 CNV deletion 17901297
nsv460700 CNV loss 19166990
nsv470638 CNV loss 18288195
nsv508221 CNV deletion 20534489
nsv508222 CNV deletion 20534489
nsv513049 CNV loss 21212237
nsv519439 CNV loss 19592680
nsv590560 CNV loss 21841781
nsv590561 CNV loss 21841781
nsv834719 CNV gain 17160897

Variation tolerance for SUCLG2 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.60; 91.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUCLG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUCLG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUCLG2 Gene

Disorders for SUCLG2 Gene

Relevant External Links for SUCLG2

Genetic Association Database (GAD)
SUCLG2
Human Genome Epidemiology (HuGE) Navigator
SUCLG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUCLG2

No disorders were found for SUCLG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUCLG2 Gene

Publications for SUCLG2 Gene

  1. Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. (PMID: 9765291) Johnson J.D. … Lambeth D.O. (J. Biol. Chem. 1998) 2 3 4 64
  2. Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. (PMID: 22144915) Fan Q. … Saw S.M. (PLoS Genet. 2011) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64

Products for SUCLG2 Gene

Sources for SUCLG2 Gene

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