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SUB1 Gene

protein-coding   GIFtS: 58
GCID: GC05P032533

SUB1 Homolog (S. Cerevisiae)

  See SUB1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SUB1 Homolog (S. Cerevisiae)1 2     Activated RNA Polymerase II Transcription Cofactor 42
PC42 3 5     Activated RNA Polymerase II Transcriptional Coactivator P152
Positive Cofactor 42 3     RPO2TC13
p142 3     SUB1 Homolog3
P152     p155

External Ids:    HGNC: 199851   Entrez Gene: 109232   Ensembl: ENSG000001133877   OMIM: 6005035   UniProtKB: P539993   

Export aliases for SUB1 gene to outside databases

Previous GC identifer: GC05P032622


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SUB1 Gene:
SUB1 (SUB1 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with SUB1 include tinea unguium. GO annotations related to this gene include transcription coactivator activity and single-stranded DNA binding.

UniProtKB/Swiss-Prot: TCP4_HUMAN, P53999
Function: General coactivator that functions cooperatively with TAFs and mediates functional interactions between
upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein
transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA
(ds DNA)

Gene Wiki entry for SUB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUB1 gene promoter:
         ATF-2   Pax-2   Pax-2a   RORalpha2   MEF-2A   CREB   deltaCREB   FOXO1a   aMEF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUB1 promoter sequence
   Search Chromatin IP Primers for SUB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.3   Ensembl cytogenetic band:  5p13.3   HGNC cytogenetic band: 5p13.3

SUB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUB1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P032533:  view genomic region     (about GC identifiers)

Start:
32,531,739 bp from pter      End:
32,604,185 bp from pter
Size:
72,447 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCP4_HUMAN, P53999 (See protein sequence)
Recommended Name: Activated RNA polymerase II transcriptional coactivator p15  
Size: 127 amino acids; 14395 Da
Subunit: Homodimer. Interacts with CSTF2
Mass spectrometry: Mass=14266; Mass_error=4; Method=MALDI; Range=2-127; Source=PubMed:7809103;
Mass spectrometry: Mass=14263; Method=Electrospray; Range=2-127; Source=PubMed:16689930;
3 PDB 3D structures from and Proteopedia for SUB1:
1PCF (3D)        2C62 (3D)        2PHE (3D)    
Secondary accessions: Q96L29

Explore the universe of human proteins at neXtProt for SUB1: NX_P53999

Explore proteomics data for SUB1 at MOPED

Post-translational modifications: 

  • Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds
    DNA-binding and cofactor function, but does not affect binding to ssDNA. Seems to be phosphorylated in vivo by
    CK2 in at least 7 sites in the N-terminal Ser-rich region1
  • Ubiquitination2 at Lys53, Lys68
  • Modification sites at PhosphoSitePlus

  • See SUB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006704.3  
    ENSEMBL proteins: 
     ENSP00000422078   ENSP00000422806   ENSP00000265073   ENSP00000423356   ENSP00000426850  
     ENSP00000427100   ENSP00000423893  

    SUB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SUB1
    OriGene Protein Over-expression Lysate for SUB1
    OriGene MassSpec for SUB1
    OriGene Custom Protein Services for SUB1
    GenScript Custom Purified and Recombinant Proteins Services for SUB1
    Novus Biologicals SUB1 Proteins
    Novus Biologicals SUB1 Lysates
    Sino Biological Recombinant Protein for SUB1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SUB1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SUB1 

    SUB1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    OriGene Custom Antibody Services for SUB1
    Novus Biologicals SUB1 Antibodies
    Search for Antibodies for SUB1 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for SUB1
    LSBio Antibodies in human, mouse, rat for SUB1

    SUB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SUB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SUB1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003173 PC4
     IPR009044 ssDNA-bd_transcriptional_reg

    Graphical View of Domain Structure for InterPro Entry P53999

    ProtoNet protein and cluster: P53999

    2 Blocks protein domains:
    IPB003173 Transcriptional coactivator p15 (PC4)
    IPB009044 ssDNA-binding transcriptional regulator


    UniProtKB/Swiss-Prot: TCP4_HUMAN, P53999
    Similarity: Belongs to the transcriptional coactivator PC4 family


    Find genes that share domains with SUB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCP4_HUMAN, P53999
    Function: General coactivator that functions cooperatively with TAFs and mediates functional interactions between
    upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein
    transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA
    (ds DNA)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003697single-stranded DNA binding IDA8062391
    GO:0003713transcription coactivator activity IDA8062391
    GO:0005515protein binding IPI11389848
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SUB1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SUB1:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SUB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SUB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SUB1:
    hsa-mir-375 (MIRT019809), hsa-let-7e-5p (MIRT051658), hsa-mir-101-3p (MIRT027373)

    Block miRNA regulation of human, mouse, rat SUB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SUB1 (see all 60):
    hsa-miR-4291 hsa-miR-142-5p hsa-miR-4307 hsa-let-7d hsa-miR-513a-5p hsa-miR-29a hsa-miR-605 hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidSUB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SUB1
    Predesigned siRNA for gene silencing in human, mouse, rat SUB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SUB1

    Clone
    Products:
         
    OriGene clones in human, mouse for SUB1 (see all 7)
    OriGene ORF clones in mouse, rat for SUB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SUB1 (NM_006713)
    Sino Biological Human cDNA Clone for SUB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUB1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SUB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SUB1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCP4_HUMAN, P53999: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IDA8062391
    GO:0005730nucleolus IDA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with SUB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SUB1
    Interactions:

        GeneGlobe Interaction Network for SUB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SUB1 (P539991, 2, 3 ENSP000002650734) via UniProtKB, MINT, STRING, and/or I2D (see all 189)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2A1P684002, 3, ENSP000002172444MINT-17591 I2D: score=3 STRING: ENSP00000217244
    CSTF2P33240-11, ENSP000003620634EBI-998260,EBI-711374 I2D: score=5 STRING: ENSP00000362063
    ADAP1O756893, ENSP000002658464I2D: score=1 STRING: ENSP00000265846
    MAPK3P273613, ENSP000002630254I2D: score=1 STRING: ENSP00000263025
    PCNAP120043, ENSP000003684384I2D: score=1 STRING: ENSP00000368438
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA8062391

    Find genes that share ontologies with SUB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SUB1 (TCP4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SUB1 gene: 
    NM_006713.3  

    Unigene Cluster for SUB1:

    SUB1 homolog (S. cerevisiae)
    Hs.229641  [show with all ESTs]
    Unigene Representative Sequence: BX537584
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506237 ENST00000512913 ENST00000513013 ENST00000265073(uc003jhs.2 uc003jht.2)
    ENST00000511615 ENST00000515355 ENST00000502897 ENST00000510442 ENST00000504789
    ENST00000511988 ENST00000504016 ENST00000511175 ENST00000502453
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SUB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SUB1 (see all 60):
    hsa-miR-4291 hsa-miR-142-5p hsa-miR-4307 hsa-let-7d hsa-miR-513a-5p hsa-miR-29a hsa-miR-605 hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidSUB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SUB1
    Predesigned siRNA for gene silencing in human, mouse, rat SUB1
    Clone
    Products:
         
    OriGene clones in human, mouse for SUB1 (see all 7)
    OriGene ORF clones in mouse, rat for SUB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SUB1 (NM_006713)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUB1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SUB1
    OriGene qSTAR qPCR primer pairs in human, mouse for SUB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SUB1
      QuantiTect SYBR Green Assays in human, mouse, rat SUB1
      QuantiFast Probe-based Assays in human, mouse, rat SUB1

    Additional mRNA sequence: 

    AB209285.1 AK125970.1 AK294124.1 AK307268.1 AK311754.1 BC009610.1 BC010537.1 BC018189.1 
    BC022339.1 BC063402.1 BC071655.1 BC105972.1 BX537584.1 CR456902.1 U12979.1 X79805.1 

    Selected DOTS entries (see all 41):

    DT.97855976  DT.100691357  DT.95099103  DT.120811374  DT.92465335  DT.95270423  DT.120811321  DT.120811300 
    DT.314294  DT.40115600  DT.95270420  DT.95270432  DT.91885068  DT.92465344  DT.100882319  DT.102835479 
    DT.100651668  DT.120811292  DT.120811318  DT.120811319  DT.100882321  DT.91851985  DT.95287516  DT.100746638 

    Selected AceView cDNA sequences (see all 738):

    BE784583 AL712884 BM451469 BQ631951 BC018189 BC022339 AA355902 C05492 
    CR596049 BX495955 AU139980 BU070647 H97042 CR611066 BU741854 BC071655 
    CN483621 BM834230 BX107729 BM503882 CF552930 CA412231 BP350075 BQ231664 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SUB1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
    SP1:                          -                                 
    SP2:                          -                                 
    SP3:                    -     -                                 
    SP4:                                                            


    ECgene alternative splicing isoforms for SUB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SUB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAGATTG
    SUB1 Expression
    About this image


    SUB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
    SUB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.229641
        Custom PCR Arrays for SUB1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SUB1
    OriGene qSTAR qPCR primer pairs in human, mouse for SUB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SUB1
    QuantiTect SYBR Green Assays in human, mouse, rat SUB1
    QuantiFast Probe-based Assays in human, mouse, rat SUB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SUB1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sub11 , 5 SUB1 homolog (S. cerevisiae)1, 5 87.93(n)1
    93.7(a)1
      15 (5.90 cM)5
    200241  NM_011294.31  NP_035424.11 
     119813395 
    chicken
    (Gallus gallus)
    Aves SUB11 SUB1 homolog (S. cerevisiae) 85.98(n)
    90.48(a)
      427425  NM_001008479.1  NP_001008479.1 
    lizard
    (Anolis carolinensis)
    Reptilia SUB16
    SUB1 homolog (S. cerevisiae)
    79(a)
    1 ↔ 1
    GL343335.1(99621-117811)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.219922 Xenopus laevis, Similar to activated RNA polymerase more 79.56(n)    BC042264.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.154282 Transcribed sequence with moderate similarity to protein more 76.72(n)    BM026248.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T13F2.26
    Protein T13F2.2 (T13F2.2) mRNA, complete cds
    35(a)
    1 ↔ 1
    IV(9796689-9797354) WBGene00011743
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SUB1(YMR039C)4 Transcriptional coactivator, facilitates elongation more   --   13(349522-348644) 855055  NP_013753.1 


    ENSEMBL Gene Tree for SUB1 (if available)
    TreeFam Gene Tree for SUB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SUB1 gene
    1 SIMAP similar gene for SUB1 using alignment to 3 protein entries:     TCP4_HUMAN (see all proteins):
    PC4

    Find genes that share paralogs with SUB1           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for SUB1
    PGOHUM00000248229 PGOHUM00000248708 PGOHUM00000249022 PGOHUM00000249564


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SUB1 (see all 475)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs100436631,2
    C,F--32583616(+) caccaC/Tgcctg 1 -- us2k12Minor allele frequency- T:0.25NA WA 4
    rs1883152441,2
    C--32583710(+) GTTTAA/C/TCTTTT 1 -- us2k10--------
    rs1161671641,2
    F--32583792(+) CCAACA/CAATTT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1914561741,2
    --32583844(+) CCTCCA/TTAACA 1 -- us2k10--------
    rs1150510171,2
    C,F--32583944(+) AAAACT/CTGTTA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1446755971,2
    --32583960(+) GGAAGA/GGTTGC 1 -- us2k10--------
    rs117392461,2
    C,F,A,H--32584140(+) TGCAGT/CAGTAC 1 -- us2k17Minor allele frequency- C:0.37NA WA CSA EA 366
    rs1835736621,2
    --32584157(+) AGCTCA/TCTGCA 1 -- us2k10--------
    rs1383785711,2
    --32584201(+) TCTTAC/TCCTCC 1 -- us2k10--------
    rs756017561,2
    C--32584330(+) TCGGCC/TTCCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SUB1 (32531739 - 32604185 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SUB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1792e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600503    OMIM disorders: --

    1 disease for SUB1:    
    About MalaCards
    tinea unguium

    2 diseases from the University of Copenhagen DISEASES database for SUB1:
    Tinea unguium     Astigmatism

    Find genes that share disorders with SUB1           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: SUB1 (1 document)

    Export disorders for SUB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUB1 gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with SUB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators. (PubMed id 8062392)1, 2, 3 Kretzschmar M.... Meisterernst M. (Cell 1994)
    2. Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. (PubMed id 8062391)1, 2, 3 Ge H. and Roeder R.G. (Cell 1994)
    3. The coactivator p15 (PC4) initiates transcriptional activation during TFIIA-TFIID-promoter complex formation. (PubMed id 7628453)1, 2, 9 Kaiser K.... Meisterernst M. (EMBO J. 1995)
    4. Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. (PubMed id 11389848)1, 2, 9 Calvo O. and Manley J.L. (Mol. Cell 2001)
    5. A global transcription cofactor bound to juxtaposed strands of unwound DNA. (PubMed id 16415882)1, 2 Werten S. and Moras D. (Nat. Struct. Biol. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A dynamic model for PC4 coactivator function in RNA polymerase II transcription. (PubMed id 9482861)1, 2 Malik S.... Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    8. C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site. (PubMed id 9360603)1, 2 Brandsen J....Gros P. (Nat. Struct. Biol. 1997)
    9. Phosphorylation negatively regulates the function of coactivator PC4. (PubMed id 7809103)1, 2 Ge H.... Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    10. Transcriptional coactivator PC4, a chromatin-associated protein, induces chromatin condensation. (PubMed id 16982701)1, 9 Das C....Kundu T.K. (Mol. Cell. Biol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10923 HGNC: 19985 AceView: PC4 Ensembl:ENSG00000113387 euGenes: HUgn10923
    ECgene: SUB1 H-InvDB: SUB1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SUB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SUB1 gene:
    Search GeneIP for patents involving SUB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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