Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUB1 Gene

protein-coding   GIFtS: 55
GCID: GC05P032622

SUB1 homolog (S. cerevisiae)

 Explore 5 diseases affiliated with
SUB1 via our new
 Human Malady Compendium 
Biological research products
for SUB1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
SUB1 Homolog (S. Cerevisiae)1 2     P152
PC41 2 3     Activated RNA Polymerase II Transcription Cofactor 42
P141     Activated RNA Polymerase II Transcriptional Coactivator P152
Positive Cofactor 42 3     RPO2TC13
P152     SUB1 Homolog3

External Ids:    HGNC: 199851   Entrez Gene: 109232   Ensembl: ENSG000001133877   OMIM: 6005035   UniProtKB: P539993   

Export aliases for SUB1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TCP4_HUMAN, P53999
Function: General coactivator that functions cooperatively with TAFs and mediates functional interactions between
upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein
transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds
DNA)

Gene Wiki entry for SUB1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUB1 gene promoter:
         ATF-2   Pax-2   Pax-2a   RORalpha2   MEF-2A   CREB   deltaCREB   FOXO1a   aMEF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SUB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.3   Ensembl cytogenetic band:  5p13.3   HGNC cytogenetic band: 5p13.3

SUB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUB1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P032622:  view genomic region     (about GC identifiers)

Start:
32,531,739 bp from pter      End:
32,604,185 bp from pter
Size:
72,447 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TCP4_HUMAN, P53999 (See protein sequence)
Recommended Name: Activated RNA polymerase II transcriptional coactivator p15  
Size: 127 amino acids; 14395 Da
Subunit: Homodimer. Interacts with CSTF2
Subcellular location: Nucleus
Mass spectrometry: Mass=14266; Mass_error=4; Method=MALDI; Range=2-127; Source=PubMed:7809103;
Mass spectrometry: Mass=14263; Method=Electrospray; Range=2-127; Source=PubMed:16689930;
3 PDB 3D structures from and Proteopedia for SUB1:
1PCF (3D)        2C62 (3D)        2PHE (3D)    
Secondary accessions: Q96L29

Explore the universe of human proteins at neXtProt for SUB1: NX_P53999

Post-translational modifications:

  • Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds
  • DNA-binding and cofactor function, but does not affect binding to ssDNA. Seems to be phosphorylated in vivo by CK2 in
    at least 7 sites in the N-terminal Ser-rich region1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P53999

  • SUB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006704.3  
    ENSEMBL proteins: 
     ENSP00000422078   ENSP00000422806   ENSP00000265073   ENSP00000423356   ENSP00000426850  
     ENSP00000427100   ENSP00000423893  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SUB1
    OriGene Protein Over-expression Lysate: SUB1
    OriGene Custom Protein Services for SUB1 
    GenScript Custom Purified and Recombinant Proteins Services for SUB1
    Novus Biologicals SUB1 Proteins
    Novus Biologicals SUB1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for SUB1
    Uscn Proteins for SUB1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IDA8062391
    GO:0005730nucleolus IDA--


    SUB1 for ontologies           About GeneDecksing



    SUB1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SUB1 
    GenScript Custom Superior Antibodies Services for SUB1
    Novus Biologicals SUB1 Antibodies
    Abcam antibodies for SUB1 
    Uscn Antibodies for SUB1
    Search ThermoFisher Antibodies for SUB1

    Assay Products for SUB1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SUB1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SUB1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SUB1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR003173 PC4
     IPR009044 ssDNA-bd_transcriptional_reg

    Graphical View of Domain Structure for InterPro Entry P53999

    ProtoNet protein and cluster: P53999

    2 Blocks protein families:
    IPB003173 Transcriptional coactivator p15 (PC4)
    IPB009044 ssDNA-binding transcriptional regulator


    UniProtKB/Swiss-Prot: TCP4_HUMAN, P53999
    Similarity: Belongs to the transcriptional coactivator PC4 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TCP4_HUMAN, P53999
    Function: General coactivator that functions cooperatively with TAFs and mediates functional interactions between
    upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein
    transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds
    DNA)

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: SUB1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUB1
    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate SUB1 (see all 60):
    hsa-miR-4291 hsa-miR-142-5p hsa-miR-4307 hsa-let-7d hsa-miR-513a-5p hsa-miR-29a hsa-miR-605 hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidSUB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUB1 (see all 7)
    OriGene shRNA RFP: SUB1
    OriGene siRNA: SUB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SUB1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUB1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUB1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SUB1 (NM_006713)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUB1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SUB1
    Search LifeMap BioReagents cell lines for SUB1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUB1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003697single-stranded DNA binding IDA8062391
    GO:0003713transcription coactivator activity IDA8062391
    GO:0005515protein binding IPI11389848


    SUB1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SUB1:
     Decreased POU5F1-GFP protein e 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SUB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for SUB1 (P539991, 2, 3 ENSP000002650734) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2A1P684002, 3, ENSP000002172444MINT-17591 I2D: score=3 STRING: ENSP00000217244
    TAF1P216753, ENSP000002760724I2D: score=2 STRING: ENSP00000276072
    GTF2A1LQ9UNN43, ENSP000003845974I2D: score=1 STRING: ENSP00000384597
    PCNAP120043, ENSP000003684384I2D: score=1 STRING: ENSP00000368438
    RCOR1Q9UKL03, ENSP000002622414I2D: score=1 STRING: ENSP00000262241
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA8062391


    SUB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUB1
    Search CenterWatch for drugs/clinical trials and news about SUB1 / TCP4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SUB1 gene: 
    NM_006713.3  

    Unigene Cluster for SUB1:

    SUB1 homolog (S. cerevisiae)
    Hs.229641  [show with all ESTs]
    Unigene Representative Sequence: BX537584
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506237 ENST00000512913 ENST00000513013 ENST00000265073(uc003jhs.2 uc003jht.2)
    ENST00000511615 ENST00000515355 ENST00000502897 ENST00000510442 ENST00000504789
    ENST00000511988 ENST00000504016 ENST00000511175 ENST00000502453

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: SUB1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUB1
    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate SUB1 (see all 60):
    hsa-miR-4291 hsa-miR-142-5p hsa-miR-4307 hsa-let-7d hsa-miR-513a-5p hsa-miR-29a hsa-miR-605 hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidSUB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUB1 (see all 7)
    OriGene shRNA RFP: SUB1
    OriGene siRNA: SUB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUB1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUB1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUB1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SUB1 (NM_006713)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUB1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SUB1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SUB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUB1

    Additional cDNA sequence: 

    AB209285.1 AK125970.1 AK294124.1 AK307268.1 AK311754.1 BC009610.1 BC010537.1 BC018189.1 
    BC022339.1 BC063402.1 BC071655.1 BC105972.1 BX537584.1 CR456902.1 U12979.1 X79805.1 

    24/42 DOTS entries (see all 42):

    DT.97855976  DT.100691357  DT.95099103  DT.120811374  DT.92465335  DT.95270423  DT.120811321  DT.314294 
    DT.120811300  DT.40115600  DT.95270420  DT.95270432  DT.91885068  DT.92465344  DT.100882319  DT.102835479 
    DT.100651668  DT.120811292  DT.120811318  DT.120811319  DT.100882321  DT.100882333  DT.91851985  DT.95287516 

    24/738 AceView cDNA sequences (see all 738):

    AV716503 AA252476 BG290073 BC010537 CA419058 BM835033 AA700752 AV714165 
    AL710938 AA249240 AV716638 AA457082 BE790872 H97042 BP350075 BM718888 
    CD676685 BE784583 BM090954 BM971270 BU741854 BM835245 AI308856 AV716379 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SUB1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
    SP1:                          -                                 
    SP2:                          -                                 
    SP3:                    -     -                                 
    SP4:                                                            


    ECgene alternative splicing isoforms for SUB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTCAGATTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SUB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUB1

    SOURCE GeneReport for Unigene cluster: Hs.229641
        SABiosciences Custom PCR Arrays for SUB1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SUB1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SUB1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUB1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUB1 gene from 9/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sub11 , 5 SUB1 homolog (S. cerevisiae)1, 5 87.93(n)1
    93.7(a)1
      15 (5.90 cM)5
    200241  NM_011294.31  NP_035424.11 
     119813395 
    chicken
    (Gallus gallus)
    Aves SUB11 SUB1 homolog (S. cerevisiae) 85.98(n)
    90.48(a)
      427425  NM_001008479.1  NP_001008479.1 
    lizard
    (Anolis carolinensis)
    Reptilia SUB16
    --
    86(a)
    1 ↔ 1
    GL343335.1(104294-113961)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.219922 Xenopus laevis, Similar to activated RNA polymerase more 79.56(n)    BC042264.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.154282 Transcribed sequence with moderate similarity to protein more 76.72(n)    BM026248.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ssb-c31a6
    Single stranded-binding protein c31A
    35(a)
    1 ↔ 1
    2L(8211347-8211938)
    worm
    (Caenorhabditis elegans)
    Secernentea T13F2.26
    Putative RNA polymerase II transcriptional coactiv...
    32(a)
    1 ↔ 1
    IV(9796669-9797336)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G009806
    KIWI6
    (see all 4)
    zinc knuckle (CCHC-type) family protein
    RNA polymerase II transcriptional coactivator KIWI...
    (see all 4)
    5(a)
    34(a)
    (see all 4)
    possible ortholog
    many → 1
    (see all 4)
    4(422478-424588)
    5(2875232-2876575)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    RNA polymerase II transcriptional coactivator KIWI...
    RNA polymerase II transcriptional coactivator KELP...
    36(a)
    19(a)
    1 ↔ 1
    possible ortholog
    2(20878405-20880649)
    1(29279081-29281856)


    ENSEMBL Gene Tree for SUB1 (if available)
    TreeFam Gene Tree for SUB1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUB1 gene
    1 SIMAP similar gene for SUB1 using alignment to 3 protein entries:     TCP4_HUMAN (see all proteins):
    PC4

    SUB1 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for SUB1
    PGOHUM00000248229 PGOHUM00000248708 PGOHUM00000249022 PGOHUM00000249564


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/386 NCBI SNPs in SUB1 are shown (see all 386    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs100436631,2
    C,--32583616(+) caccaC/Tgcctg 1 -- us2k12Minor allele frequency- T:0.25NA WA 4
    rs1883152441,2
    --32583710(+) GTTTAA/CCTTTT 1 -- us2k10--------
    rs1161671641,2
    F,--32583792(+) CCAACA/CAATTT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1914561741,2
    --32583844(+) CCTCCA/TTAACA 1 -- us2k10--------
    rs1150510171,2
    C,F,--32583944(+) AAAACT/CTGTTA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1446755971,2
    --32583960(+) GGAAGA/GGTTGC 1 -- us2k10--------
    rs117392461,2
    C,F,A,H,--32584140(+) TGCAGT/CAGTAC 1 -- us2k17Minor allele frequency- C:0.37NA WA CSA EA 366
    rs1835736621,2
    --32584157(+) AGCTCA/TCTGCA 1 -- us2k10--------
    rs1383785711,2
    --32584201(+) TCTTAC/TCCTCC 1 -- us2k10--------
    rs756017561,2
    C,--32584330(+) TCGGCC/TTCCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SUB1 (32531739 - 32604185 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SUB1
         1 CNV: 3552

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SUB1
    DNA2.0 Custom Variant and Variant Library Synthesis for SUB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SUB1 for disorders           About GeneDecksing

    OMIM gene information: 600503    OMIM disorders: --

    5 diseases for SUB1:    About MalaCards
    cri-du-chat syndrome    tinea unguium    dna topoisomerase i    dermatophytosis
    astigmatism

    1 disease from the University of Copenhagen DISEASES database for SUB1:
    Dermatophytosis
    Human Genome Epidemiology (HuGE) Navigator: SUB1 (1 document)

    Export disorders for SUB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUB1 gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with SUB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators. (PubMed id 8062392)1, 2, 3 Kretzschmar M.... Meisterernst M. (1994)
    2. Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. (PubMed id 8062391)1, 2, 3 Ge H. and Roeder R.G. (1994)
    3. The coactivator p15 (PC4) initiates transcriptional activation during TFIIA-TFIID-promoter complex formation. (PubMed id 7628453)1, 2, 9 Kaiser K.... Meisterernst M. (1995)
    4. Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. (PubMed id 11389848)1, 2, 9 Calvo O. and Manley J.L. (2001)
    5. A global transcription cofactor bound to juxtaposed strands of unwound DNA. (PubMed id 16415882)1, 2 Werten S. and Moras D. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A dynamic model for PC4 coactivator function in RNA polymerase II transcription. (PubMed id 9482861)1, 2 Malik S.... Roeder R.G. (1998)
    8. C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site. (PubMed id 9360603)1, 2 Brandsen J....Gros P. (1997)
    9. Phosphorylation negatively regulates the function of coactivator PC4. (PubMed id 7809103)1, 2 Ge H.... Roeder R.G. (1994)
    10. Transcriptional coactivator PC4, a chromatin-associated protein, induces chromatin condensation. (PubMed id 16982701)1, 9 Das C....Kundu T.K. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10923 HGNC: 19985 AceView: PC4 Ensembl:ENSG00000113387 euGenes: HUgn10923
    ECgene: SUB1 H-InvDB: SUB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SUB1 gene:
    Search GeneIP for patents involving SUB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SUB1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUB1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SUB1  
     OriGene Protein Over-expression Lysate for SUB1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SUB1   OriGene 3'-UTR Clone for SUB1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUB1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUB1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SUB1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SUB1   OriGene Custom Protein Services for SUB1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SUB1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SUB1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUB1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUB1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUB1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUB1
     GenScript Custom Purified and Recombinant Proteins Services for SUB1 GenScript cDNA clones with any tag delivered in your preferred vector for SUB1
     GenScript Custom Assay Services for SUB1 GenScript Custom Superior Antibodies Services for SUB1
     GenScript Custom overexpressing Cell Line Services for SUB1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SUB1 promoter
     Search Chromatin IP Primers for SUB1
     RT2 qPCR Primer Assay in human, mouse, rat SUB1
     GNC Network for SUB1
     SABiosciences Custom PCR Arrays for SUB1
     Search Tocris compounds for SUB1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SUB1 antibodies
     SUB1 proteins
     SUB1 lysates
     Antibodies for SUB1
     See all of Abcam's Antibodies, Kits and Proteins for SUB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SUB1




     SUB1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SUB1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUB1
     SwitchGear 3'UTR luciferase reporter plasmids for SUB1
     SwitchGear Promoter luciferase reporter plasmids for SUB1
     Search ThermoFisher Antibodies for SUB1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUB1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SUB1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4