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STYXL1 Gene

protein-coding   GIFtS: 48
GCID: GC07M075625

Serine/Threonine/Tyrosine Interacting-Like 1

(Previous name: dual specificity phosphatase 24 (putative))
(Previous symbol: DUSP24)
  Search for STYXL1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Threonine/Tyrosine Interacting-Like 11 2     Map Kinase Phosphatase-Like Protein MK-STYX2 3
DUSP241 2 3     MK-STYX2
Dual Specificity Phosphatase 24 (Putative)1 2     Serine/Threonine/Tyrosine-Interacting-Like Protein 12
Dual Specificity Phosphatase Inhibitor MK-STYX2 3     MKSTYX3
Dual Specificity Protein Phosphatase 242 3     

External Ids:    HGNC: 181651   Entrez Gene: 516572   Ensembl: ENSG000001279527   UniProtKB: Q9Y6J83   

Export aliases for STYXL1 gene to outside databases

Previous GC identifers: GC07M075272 GC07M075463 GC07M070712


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STYXL1 Gene:
STYXL1 (serine/threonine/tyrosine interacting-like 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: STYL1_HUMAN, Q9Y6J8
Function: Probable pseudophosphatase. Contains a Ser residue instead of a conserved Cys residue in the dsPTPase
catalytic loop which probably renders it catalytically inactive as a phosphatase. The binding pocket may be
however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases

Gene Wiki entry for STYXL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the STYXL1 gene promoter:
         ER-alpha   GATA-3   Tal-1beta   GATA-1   GATA-2   POU2F1   FOXO1a   ITF-2   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTYXL1 promoter sequence
   Search Chromatin IP Primers for STYXL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STYXL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

STYXL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STYXL1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M075625:  view genomic region     (about GC identifiers)

Start:
75,625,655 bp from pter      End:
75,677,322 bp from pter
Size:
51,668 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 74,958,719-75,010,385     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STYL1_HUMAN, Q9Y6J8 (See protein sequence)
Recommended Name: Serine/threonine/tyrosine-interacting-like protein 1  
Size: 313 amino acids; 35818 Da
Secondary accessions: Q9UBP1 Q9UK06 Q9UK07 Q9UKG2 Q9UKG3
Alternative splicing: 5 isoforms:  Q9Y6J8-1   Q9Y6J8-2   Q9Y6J8-3   Q9Y6J8-4   Q9Y6J8-5   

Explore the universe of human proteins at neXtProt for STYXL1: NX_Q9Y6J8

Explore proteomics data for STYXL1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys21
  • Modification sites at PhosphoSitePlus

  • See STYXL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057170.1  
    ENSEMBL proteins: 
     ENSP00000352726   ENSP00000343383   ENSP00000403033   ENSP00000404495   ENSP00000392221  
     ENSP00000406073   ENSP00000411812   ENSP00000248600   ENSP00000353798  

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    Cloud-Clone Corp. Proteins for STYXL1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPT: Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

    4 InterPro protein domains:
     IPR001763 Rhodanese-like_dom
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR024950 DUSP
     IPR000340 Dual-sp_phosphatase_cat-dom

    Graphical View of Domain Structure for InterPro Entry Q9Y6J8

    ProtoNet protein and cluster: Q9Y6J8

    2 Blocks protein domains:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: STYL1_HUMAN, Q9Y6J8
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with STYXL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STYL1_HUMAN, Q9Y6J8
    Function: Probable pseudophosphatase. Contains a Ser residue instead of a conserved Cys residue in the dsPTPase
    catalytic loop which probably renders it catalytically inactive as a phosphatase. The binding pocket may be
    however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008138NOT protein tyrosine/serine/threonine phosphatase activity IKR--
         
    Find genes that share ontologies with STYXL1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for STYXL1:
     Apoptosis resistance  Decreased focal adhesion (FA)   Stronger migration 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STYXL1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STYXL1
    Interactions:

        Search GeneGlobe Interaction Network for STYXL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for STYXL1 (Q9Y6J83 ENSP000002486004) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AESQ081173, ENSP000002215614I2D: score=2 STRING: ENSP00000221561
    EHD4Q9H2233, ENSP000002203254I2D: score=2 STRING: ENSP00000220325
    PSPHP783303, ENSP000002756054I2D: score=2 STRING: ENSP00000275605
    SMC1AQ146833, ENSP000003234214I2D: score=2 STRING: ENSP00000323421
    DDOSTP396563, ENSP000003641884I2D: score=1 STRING: ENSP00000364188
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470NOT protein dephosphorylation IKR--
    GO:0035556intracellular signal transduction TAS9757831

    Find genes that share ontologies with STYXL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STYXL1 (STYL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STYXL1 gene: 
    NM_016086.2  

    Unigene Cluster for STYXL1:

    Serine/threonine/tyrosine interacting-like 1
    Hs.11615  [show with all ESTs]
    Unigene Representative Sequence: AK308912
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359697 ENST00000340062 ENST00000430497 ENST00000438695 ENST00000431581(uc003uen.1)
    ENST00000454618 ENST00000451157(uc010ldg.2 uc010ldh.2) ENST00000474328
    ENST00000460184 ENST00000248600(uc003uef.3 uc011kgg.2 uc003ueh.3 uc011kgf.2 uc003uek.4 uc003uel.3 uc003uem.3)
    ENST00000360591
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat STYXL1
      QuantiFast Probe-based Assays in human, mouse, rat STYXL1

    Additional mRNA sequence: 

    AF069762.1 AF169647.1 AF169648.1 AF188201.1 AF188202.1 AF188203.1 AF188204.1 AK308828.1 
    AK308912.1 AY927581.1 BC024035.2 BX537896.1 

    Selected DOTS entries (see all 25):

    DT.121059080  DT.100815749  DT.121058992  DT.454240  DT.97811052  DT.99934494  DT.92028328  DT.100815753 
    DT.100815751  DT.121058999  DT.121058860  DT.121058865  DT.121058986  DT.100815746  DT.121058944  DT.121059038 
    DT.92432633  DT.95163674  DT.121058851  DT.121058961  DT.40259737  DT.92432631  DT.100815755  DT.121058935 

    Selected AceView cDNA sequences (see all 367):

    CA425110 AI928433 BM674401 CR604706 AI092561 BM758538 CB853481 AW593087 
    AA782050 CR606386 CA431409 AA431177 CR605601 BU630357 H17476 T35406 
    NM_016086 BQ233752 BQ421226 AA470406 BX406196 BU632819 NM_031925 BM797251 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STYXL1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
    SP1:                                                        -                                                   
    SP2:              -                 -     -     -     -     -                                                   
    SP3:              -                                                                                             
    SP4:              -                                         -                                                   
    SP5:                                      -     -     -     -                                                   


    ECgene alternative splicing isoforms for STYXL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STYXL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCCGCTCT
    STYXL1 Expression
    About this image

    STYXL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STYXL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.11615
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for STYXL1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Styxl11 , 5 serine/threonine/tyrosine interacting-like 11, 5 73.7(n)1
    64.54(a)1
      5 (75.38 cM)5
    765711  NM_029659.41  NP_083935.31 
     1357472205 
    chicken
    (Gallus gallus)
    Aves STYXL11 serine/threonine/tyrosine interacting-like 1 59.16(n)
    51.45(a)
      417518  XM_415766.2  XP_415766.1 
    lizard
    (Anolis carolinensis)
    Reptilia STYXL16
    serine/threonine/tyrosine interacting-like 1
    51(a)
    1 ↔ 1
    GL343734.1(104958-117408)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.320932 Xenopus laevis transcribed sequence with weak similarity to protein refNP_057170.1 (H.sapiens) map kinase phosphatase-like protein MK-STYX [Homo sapiens] less 75.44(n)    BJ619069.1 
    zebrafish
    (Danio rerio)
    Actinopterygii styxl11 serine/threonine/tyrosine interacting-like 1 53.06(n)
    42.18(a)
      447880  NM_001004619.1  NP_001004619.1 


    ENSEMBL Gene Tree for STYXL1 (if available)
    TreeFam Gene Tree for STYXL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STYXL1 gene
    1 SIMAP similar gene for STYXL1 using alignment to 5 protein entries:     STYL1_HUMAN (see all proteins):
    DKFZp686O05147

    Find genes that share paralogs with STYXL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STYXL1 (see all 1069)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836531541,2
    --75626154(+) TTCCTA/GTTTCA 1 -- int10--------
    rs1172051831,2
    F--75626276(+) TAATGG/TAAAGA 1 -- int11Minor allele frequency- T:0.01EA 120
    rs1452295661,2
    --75626356(+) AAGTAC/TAGGAA 1 -- int10--------
    rs782732031,2
    C,F--75626400(+) CTCCAT/CCTGGA 1 -- int12Minor allele frequency- C:0.07NA EA 240
    rs1162922961,2
    C,F--75626418(+) CAAACG/AAAAAA 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1491588861,2
    C--75626688(+) CGGAGA/GTTGCA 1 -- int10--------
    rs1424290211,2
    --75626821(+) AACATC/TACACT 1 -- int10--------
    rs1148077521,2
    C,F--75626828(+) CACTCA/TATGGC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1429707351,2
    C--75627038(+) AGATT-/ACACACA 1 -- int10--------
    rs1512975601,2
    C--75627089(+) TGCAGA/GATACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for STYXL1 (75625655 - 75677322 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STYXL1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821252CNV Deletion20802225
    dgv120n16CNV Deletion17901297
    esv2734678CNV Deletion23290073
    esv2666194CNV Deletion23128226
    dgv1217e199CNV Deletion23128226
    nsv888386CNV Gain21882294
    nsv819156CNV Gain19587683
    dgv1117n67CNV Gain20364138
    nsv428173CNV Gain18775914
    nsv528969CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STYXL1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with STYXL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains. (PubMed id 9757831)1, 2, 3 Wishart M.J. and Dixon J.E. (Trends Biochem. Sci. 1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    4. The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation. (PubMed id 20180778)1, 9 Hinton S.D....Tonks N.K. (Biochem. J. 2010)
    5. The pseudophosphatase MK-STYX inhibits stress granule assembly independently of Ser149 phosphorylation of G3BP-1. (PubMed id 23163895)1 Barr J.E....Hinton S.D. (FEBS J. 2013)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis. (PubMed id 21262771)1 Niemi N.M....MacKeigan J.P. (Mol. Cell. Biol. 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    10. EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin. (PubMed id 15735734)1 Siligan C....Kovar H. (Oncogene 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51657 HGNC: 18165 AceView: MK-STYXandTMPIT Ensembl:ENSG00000127952 euGenes: HUgn51657
    ECgene: STYXL1 H-InvDB: STYXL1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STYXL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STYXL1 gene:
    Search GeneIP for patents involving STYXL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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