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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STYXL1 Gene

protein-coding   GIFtS: 49
GCID: GC07M075625

serine/threonine/tyrosine interacting-like 1

(Previous name: dual specificity phosphatase 24 (putative) )
(Previous symbol: DUSP24)
 Explore 1 disease affiliated with
STYXL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STYXL1    

Aliases
for STYXL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Serine/Threonine/Tyrosine Interacting-Like 11 2     Dual Specificity Protein Phosphatase 242 3
DUSP241 2 3     Map Kinase Phosphatase-Like Protein MK-STYX2 3
MK-STYX1 2     Serine/Threonine/Tyrosine-Interacting-Like Protein 12
Dual Specificity Phosphatase 24 (Putative)1 2     MKSTYX3
Dual Specificity Phosphatase Inhibitor MK-STYX2 3     

External Ids:    HGNC: 181651   Entrez Gene: 516572   Ensembl: ENSG000001279527   UniProtKB: Q9Y6J83   

Export aliases for STYXL1 gene to outside databases

Previous GC identifers: GC07M075272 GC07M075463 GC07M070712


Summaries
for STYXL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: STYL1_HUMAN, Q9Y6J8
Function: Probable pseudophosphatase. Contains a Ser residue instead of a conserved Cys residue in the dsPTPase
catalytic loop which probably renders it catalytically inactive as a phosphatase. The binding pocket may be however
sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases

Gene Wiki entry for STYXL1


Genomic Views
for STYXL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STYXL1 gene promoter:
         ER-alpha   GATA-3   Tal-1beta   GATA-1   GATA-2   POU2F1   FOXO1a   ITF-2   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STYXL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for STYXL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STYXL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

STYXL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STYXL1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M075625:  view genomic region     (about GC identifiers)

Start:
 75,625,655 bp from pter      End:
 75,677,322 bp from pter
Size:
 51,668 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 74,958,719-75,010,385     

Proteins
for STYXL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STYL1_HUMAN, Q9Y6J8 (See protein sequence)
Recommended Name: Serine/threonine/tyrosine-interacting-like protein 1  
Size: 313 amino acids; 35818 Da
Secondary accessions: Q9UBP1 Q9UK06 Q9UK07 Q9UKG2 Q9UKG3
Alternative splicing: 5 isoforms:  Q9Y6J8-1   Q9Y6J8-2   Q9Y6J8-3   Q9Y6J8-4   Q9Y6J8-5   

Explore the universe of human proteins at neXtProt for STYXL1: NX_Q9Y6J8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y6J8

    • STYXL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057170.1  
    ENSEMBL proteins: 
     ENSP00000352726   ENSP00000343383   ENSP00000403033   ENSP00000404495   ENSP00000392221  
     ENSP00000406073   ENSP00000411812   ENSP00000248600   ENSP00000353798  

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    Uscn Proteins for STYXL1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----


    STYXL1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for STYXL1

    Protein Domains /
    Families
    for STYXL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STYXL1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001763 Rhodanese-like_dom
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR024950 DUSP
     IPR000340 Dual-sp_phosphatase_cat-dom

    Graphical View of Domain Structure for InterPro Entry Q9Y6J8

    ProtoNet protein and cluster: Q9Y6J8

    2 Blocks protein families:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: STYL1_HUMAN, Q9Y6J8
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Function
    for STYXL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STYL1_HUMAN, Q9Y6J8
    Function: Probable pseudophosphatase. Contains a Ser residue instead of a conserved Cys residue in the dsPTPase
    catalytic loop which probably renders it catalytically inactive as a phosphatase. The binding pocket may be however
    sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases

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    Gene Editing
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    Clone
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008138NOT protein tyrosine/serine/threonine phosphatase activity IKR--


    STYXL1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for STYXL1:
     Apoptosis resistance  Decreased focal adhesion (FA)   Stronger migration 


    Pathways & Interactions
    for STYXL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STYXL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/14 Interacting proteins for STYXL1 (Q9Y6J83 ENSP000002486004) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AESQ081173, ENSP000002215614I2D: score=2 STRING: ENSP00000221561
    EHD4Q9H2233, ENSP000002203254I2D: score=2 STRING: ENSP00000220325
    PSPHP783303, ENSP000002756054I2D: score=2 STRING: ENSP00000275605
    SMC1AQ146833, ENSP000003234214I2D: score=2 STRING: ENSP00000323421
    DDOSTP396563, ENSP000003641884I2D: score=1 STRING: ENSP00000364188
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470NOT protein dephosphorylation IKR--
    GO:0035556intracellular signal transduction TAS9757831


    STYXL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for STYXL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STYXL1
    Search CenterWatch for drugs/clinical trials and news about STYXL1 / STYL1 

    Transcripts
    for STYXL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STYXL1 gene: 
    NM_016086.2  

    Unigene Cluster for STYXL1:

    Serine/threonine/tyrosine interacting-like 1
    Hs.11615  [show with all ESTs]
    Unigene Representative Sequence: AK308912
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359697 ENST00000340062 ENST00000430497 ENST00000438695 ENST00000431581(uc003uen.1)
    ENST00000454618 ENST00000451157(uc010ldg.2 uc010ldh.2) ENST00000474328
    ENST00000460184 ENST00000248600(uc003uef.3 uc011kgg.2 uc003ueh.3 uc011kgf.2 uc003uek.4 uc003uel.3 uc003uem.3)
    ENST00000360591

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    Additional cDNA sequence: 

    AF069762.1 AF169647.1 AF169648.1 AF188201.1 AF188202.1 AF188203.1 AF188204.1 AK308828.1 
    AK308912.1 AY927581.1 BC024035.2 BX537896.1 

    24/25 DOTS entries (see all 25):

    DT.121059080  DT.100815749  DT.121058992  DT.454240  DT.97811052  DT.99934494  DT.92028328  DT.100815753 
    DT.100815751  DT.121058999  DT.121058860  DT.121058865  DT.121058986  DT.100815746  DT.121058944  DT.121059038 
    DT.92432633  DT.95163674  DT.121058851  DT.121058961  DT.40259737  DT.92432631  DT.100815755  DT.121058935 

    24/367 AceView cDNA sequences (see all 367):

    CA423417 AA470406 CR609218 CR614474 AA477639 BM674401 BM701267 AF188203 
    BM966994 NM_031925 CR605601 BU630357 AI092561 CK906121 BM726249 BU632819 
    CA309269 AF188201 BM927937 CR611494 CD370390 CR615380 BQ233752 CR606386 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for STYXL1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
    SP1:                                                        -                                                   
    SP2:              -                 -     -     -     -     -                                                   
    SP3:              -                                                                                             
    SP4:              -                                         -                                                   
    SP5:                                      -     -     -     -                                                   


    ECgene alternative splicing isoforms for STYXL1

    Expression
    for STYXL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STYXL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATCCGCTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See STYXL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STYXL1

    SOURCE GeneReport for Unigene cluster: Hs.11615
        SABiosciences Custom PCR Arrays for STYXL1
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    In Situ
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    Orthologs
    for STYXL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for STYXL1 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Styxl11 , 5 serine/threonine/tyrosine interacting-like 11, 5 74.44(n)1
    65.18(a)1    		   5 (75.38 cM)5
    765711  NM_029659.41  NP_083935.31 
     1357472205 
    chicken
    (Gallus gallus)    		 Aves STYXL11 serine/threonine/tyrosine interacting-like 1 59.91(n)
    52.09(a)    		   417518  XM_003642391.1  XP_003642439.1 
    lizard
    (Anolis carolinensis)    		 Reptilia STYXL16
    		 --
    		 56(a)
    		 1 ↔ 1
    		 GL343734.1(109068-116681)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.320932 Xenopus laevis transcribed sequence with weak similarity to protein refNP_057170.1 (H.sapiens) map kinase phosphatase-like protein MK-STYX [Homo sapiens] less 75.44(n)    BJ619069.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii styxl11 serine/threonine/tyrosine interacting-like 1 54.08(n)
    43.2(a)    		   447880  NM_001004619.1  NP_001004619.1 


    ENSEMBL Gene Tree for STYXL1 (if available)
    TreeFam Gene Tree for STYXL1 (if available) 

    Paralogs
    for STYXL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for STYXL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/861 NCBI SNPs in STYXL1 are shown (see all 861)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs776957271,2
    		--70712140(+) GAAGCA/GCTGGG 1 -- us2k10--------
    rs10445261,2
    		C--70712619(-) CTGATC/TTTCTC 1 -- us2k1 ese33Minor allele frequency- T:0.00MN NA 188
    rs1850698281,2
    		--75625356(+) CTAGAC/GAAGGC 1 -- int10--------
    rs1165197271,2
    		F,--75625369(+) GGCTTG/AGTATC 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1893837681,2
    		--75625385(+) GACTAA/GGGGAC 1 -- int10--------
    rs1927230201,2
    		--75625560(+) GCCCGC/TGACAC 1 -- int10--------
    rs1463053561,2
    		--75625576(+) GGATGC/TGGGTT 1 -- int10--------
    rs1394664341,2
    		--75625659(+) CTAACA/GTGAGA 1 -- ut310--------
    rs2022090941,2
    		--75625768(+) CCTTCA/GGTGGG 1 -- ut310--------
    rs1500154741,2
    		C,F,--75625797(+) GAGCGG/CATCCA 2 /P /A mis12Minor allele frequency- C:0.01NA EU 5875

    HapMap Linkage Disequilibrium report for STYXL1 (75625655 - 75677322 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for STYXL1
         4 CNVs: 3686 59422 22956 64865

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    Disorders / Diseases
    for STYXL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STYXL1 for disorders           About GeneDecksing

    1 disease for STYXL1:    About MalaCards
    sarcoma


    Export disorders for STYXL1 gene to outside databases

    Publications
    for STYXL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STYXL1 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with STYXL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains. (PubMed id 9757831)1, 2, 3 Wishart M.J. and Dixon J.E. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation. (PubMed id 20180778)1, 9 Hinton S.D....Tonks N.K. (2010)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. MK-STYX, a catalytically inactive phosphatase regulat ing mitochondrially dependent apoptosis. (PubMed id 21262771)1 Niemi N.M....MacKeigan J.P. (2011)
    7. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
    8. EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin. (PubMed id 15735734)1 Siligan C....Kovar H. (2005)
    9. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
    10. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)

    External Searches for STYXL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing STYXL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51657 HGNC: 18165 AceView: MK-STYXandTMPIT Ensembl:ENSG00000127952 euGenes: HUgn51657
    ECgene: STYXL1 H-InvDB: STYXL1

    Other Databases showing STYXL1 gene

    (According to HUGE)
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    Specialized Databases showing STYXL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STYXL1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for STYXL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STYXL1 gene:
    Search GeneIP for patents involving STYXL1

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