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Aliases for STYXL1 Gene

Aliases for STYXL1 Gene

  • Serine/Threonine/Tyrosine Interacting-Like 1 2 3
  • Dual Specificity Phosphatase Inhibitor MK-STYX 3 4
  • Map Kinase Phosphatase-Like Protein MK-STYX 3 4
  • Dual Specificity Phosphatase 24 (Putative) 2 3
  • Dual Specificity Protein Phosphatase 24 3 4
  • DUSP24 3 4
  • Serine/Threonine/Tyrosine-Interacting-Like Protein 1 3
  • MK-STYX 3
  • MKSTYX 4

External Ids for STYXL1 Gene

Previous Symbols for STYXL1 Gene

  • DUSP24

Summaries for STYXL1 Gene

GeneCards Summary for STYXL1 Gene

STYXL1 (Serine/Threonine/Tyrosine Interacting-Like 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for STYXL1 Gene

  • Probable pseudophosphatase. Contains a Ser residue instead of a conserved Cys residue in the dsPTPase catalytic loop which probably renders it catalytically inactive as a phosphatase. The binding pocket may be however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases

Gene Wiki entry for STYXL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STYXL1 Gene

Genomics for STYXL1 Gene

Genomic Location for STYXL1 Gene

Start:
75,996,337 bp from pter
End:
76,048,004 bp from pter
Size:
51,668 bases
Orientation:
Minus strand

Genomic View for STYXL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STYXL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STYXL1 Gene

Regulatory Elements for STYXL1 Gene

Proteins for STYXL1 Gene

  • Protein details for STYXL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6J8-STYL1_HUMAN
    Recommended name:
    Serine/threonine/tyrosine-interacting-like protein 1
    Protein Accession:
    Q9Y6J8
    Secondary Accessions:
    • Q9UBP1
    • Q9UK06
    • Q9UK07
    • Q9UKG2
    • Q9UKG3

    Protein attributes for STYXL1 Gene

    Size:
    313 amino acids
    Molecular mass:
    35818 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STYXL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STYXL1 Gene

Proteomics data for STYXL1 Gene at MOPED

Post-translational modifications for STYXL1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys21

No data available for DME Specific Peptides for STYXL1 Gene

Domains for STYXL1 Gene

Gene Families for STYXL1 Gene

HGNC:
  • DUSPT :Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

UniProtKB/Swiss-Prot:

STYL1_HUMAN
Domain:
  • Contains 1 rhodanese domain.:
    • Q9Y6J8
  • Contains 1 tyrosine-protein phosphatase domain.:
    • Q9Y6J8
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.:
    • Q9Y6J8
genes like me logo Genes that share domains with STYXL1: view

Function for STYXL1 Gene

Molecular function for STYXL1 Gene

UniProtKB/Swiss-Prot Function: Probable pseudophosphatase. Contains a Ser residue instead of a conserved Cys residue in the dsPTPase catalytic loop which probably renders it catalytically inactive as a phosphatase. The binding pocket may be however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases

Gene Ontology (GO) - Molecular Function for STYXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with STYXL1: view

Phenotypes for STYXL1 Gene

GenomeRNAi human phenotypes for STYXL1:
genes like me logo Genes that share phenotypes with STYXL1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for STYXL1 Gene

Localization for STYXL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STYXL1 Gene COMPARTMENTS Subcellular localization image for STYXL1 gene
Compartment Confidence
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for STYXL1 Gene

Pathways for STYXL1 Gene

SuperPathways for STYXL1 Gene

No Data Available

Interacting Proteins for STYXL1 Gene

Gene Ontology (GO) - Biological Process for STYXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0035556 intracellular signal transduction TAS 9757831
genes like me logo Genes that share ontologies with STYXL1: view

No data available for Pathways by source for STYXL1 Gene

Transcripts for STYXL1 Gene

Unigene Clusters for STYXL1 Gene

Serine/threonine/tyrosine interacting-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STYXL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: - - - -
SP6: -
SP7: - - - - - -
SP8:
SP9: - - -
SP10: -

Relevant External Links for STYXL1 Gene

GeneLoc Exon Structure for
STYXL1
ECgene alternative splicing isoforms for
STYXL1

Expression for STYXL1 Gene

mRNA expression in normal human tissues for STYXL1 Gene

SOURCE GeneReport for Unigene cluster for STYXL1 Gene Hs.11615

genes like me logo Genes that share expressions with STYXL1: view

Orthologs for STYXL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STYXL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STYXL1 36
  • 98.72 (n)
  • 98.08 (a)
STYXL1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STYXL1 36
  • 79.87 (n)
  • 76.3 (a)
STYXL1 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STYXL1 36
  • 82.43 (n)
  • 77.64 (a)
STYXL1 37
  • 41 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Styxl1 36
  • 73.7 (n)
  • 64.54 (a)
Styxl1 16
Styxl1 37
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STYXL1 37
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STYXL1 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Styxl1 36
  • 75.43 (n)
  • 66.03 (a)
chicken
(Gallus gallus)
Aves STYXL1 36
  • 59.16 (n)
  • 51.45 (a)
STYXL1 37
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STYXL1 37
  • 51 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32093 36
tropical clawed frog
(Silurana tropicalis)
Amphibia styxl1 36
  • 62.24 (n)
  • 53.06 (a)
zebrafish
(Danio rerio)
Actinopterygii styxl1 36
  • 53.06 (n)
  • 42.18 (a)
styxl1 37
  • 40 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
OneToOne
Species with no ortholog for STYXL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STYXL1 Gene

ENSEMBL:
Gene Tree for STYXL1 (if available)
TreeFam:
Gene Tree for STYXL1 (if available)

Paralogs for STYXL1 Gene

Selected SIMAP similar genes for STYXL1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STYXL1: view

No data available for Paralogs for STYXL1 Gene

Variants for STYXL1 Gene

Sequence variations from dbSNP and Humsavar for STYXL1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs8565 -- 76,000,956(-) ACCCA(A/G)GGTAT reference, synonymous-codon
rs12686 -- 76,003,842(+) GTCAG(C/G/T)ATCGC missense, reference
rs1044483 -- 76,030,497(-) GAACC(A/G/T)ACAGA reference, synonymous-codon
rs1044484 -- 76,005,369(-) GAAAT(C/T)GTGCC reference, synonymous-codon
rs1894812 -- 76,028,401(+) cagag(C/T)gagac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STYXL1 Gene

Variant ID Type Subtype PubMed ID
nsv528969 CNV Gain 19592680
essv14753 CNV CNV 17122850
dgv120n16 CNV Deletion 17901297
dgv2103e1 CNV Complex 17122850
nsv428173 CNV Gain 18775914
dgv2104e1 CNV Complex 17122850
nsv888386 CNV Gain 21882294
nsv821252 CNV Deletion 20802225
nsv819156 CNV Gain 19587683
esv24008 CNV Gain+Loss 19812545
esv2734678 CNV Deletion 23290073
dgv1217e199 CNV Deletion 23128226
dgv1117n67 CNV Gain 20364138
esv2666194 CNV Deletion 23128226
dgv2105e1 CNV Complex 17122850

Relevant External Links for STYXL1 Gene

HapMap Linkage Disequilibrium report
STYXL1

Disorders for STYXL1 Gene

No disorders were found for STYXL1 Gene.

No data available for UniProtKB/Swiss-Prot for STYXL1 Gene

Publications for STYXL1 Gene

  1. Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains. (PMID: 9757831) Wishart M.J. … Dixon J.E. (Trends Biochem. Sci. 1998) 2 3 4
  2. The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation. (PMID: 20180778) Hinton S.D. … Tonks N.K. (Biochem. J. 2010) 3 23
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin. (PMID: 15735734) Siligan C. … Kovar H. (Oncogene 2005) 3

Products for STYXL1 Gene

Sources for STYXL1 Gene

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