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Aliases for STYXL1 Gene

Aliases for STYXL1 Gene

  • Serine/Threonine/Tyrosine Interacting-Like 1 2 3 5
  • Dual Specificity Phosphatase Inhibitor MK-STYX 3 4
  • Map Kinase Phosphatase-Like Protein MK-STYX 3 4
  • Dual Specificity Phosphatase 24 (Putative) 2 3
  • Dual Specificity Protein Phosphatase 24 3 4
  • DUSP24 3 4
  • MKSTYX 3 4
  • MK-STYX 3

External Ids for STYXL1 Gene

Previous HGNC Symbols for STYXL1 Gene

  • DUSP24

Previous GeneCards Identifiers for STYXL1 Gene

  • GC07M075272
  • GC07M075463
  • GC07M075625
  • GC07M070712

Summaries for STYXL1 Gene

GeneCards Summary for STYXL1 Gene

STYXL1 (Serine/Threonine/Tyrosine Interacting-Like 1) is a Protein Coding gene. GO annotations related to this gene include protein tyrosine/serine/threonine phosphatase activity.

UniProtKB/Swiss-Prot for STYXL1 Gene

  • Probable pseudophosphatase. Contains a Ser residue instead of a conserved Cys residue in the dsPTPase catalytic loop which probably renders it catalytically inactive as a phosphatase. The binding pocket may be however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases.

Gene Wiki entry for STYXL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STYXL1 Gene

Genomics for STYXL1 Gene

Regulatory Elements for STYXL1 Gene

Promoters for STYXL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STYXL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for STYXL1 Gene

Chromosome:
7
Start:
75,995,834 bp from pter
End:
76,048,004 bp from pter
Size:
52,171 bases
Orientation:
Minus strand

Genomic View for STYXL1 Gene

Genes around STYXL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STYXL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STYXL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STYXL1 Gene

Proteins for STYXL1 Gene

  • Protein details for STYXL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6J8-STYL1_HUMAN
    Recommended name:
    Serine/threonine/tyrosine-interacting-like protein 1
    Protein Accession:
    Q9Y6J8
    Secondary Accessions:
    • Q9UBP1
    • Q9UK06
    • Q9UK07
    • Q9UKG2
    • Q9UKG3

    Protein attributes for STYXL1 Gene

    Size:
    313 amino acids
    Molecular mass:
    35818 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STYXL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STYXL1 Gene

Proteomics data for STYXL1 Gene at MOPED

Post-translational modifications for STYXL1 Gene

  • Ubiquitination at Lys 21
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STYXL1 Gene

Domains & Families for STYXL1 Gene

Gene Families for STYXL1 Gene

Suggested Antigen Peptide Sequences for STYXL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6J8

UniProtKB/Swiss-Prot:

STYL1_HUMAN :
  • Contains 1 rhodanese domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Domain:
  • Contains 1 rhodanese domain.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with STYXL1: view

Function for STYXL1 Gene

Molecular function for STYXL1 Gene

UniProtKB/Swiss-Prot Function:
Probable pseudophosphatase. Contains a Ser residue instead of a conserved Cys residue in the dsPTPase catalytic loop which probably renders it catalytically inactive as a phosphatase. The binding pocket may be however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases.
genes like me logo Genes that share phenotypes with STYXL1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STYXL1 Gene

Localization for STYXL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STYXL1 Gene COMPARTMENTS Subcellular localization image for STYXL1 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for STYXL1 Gene

Pathways & Interactions for STYXL1 Gene

SuperPathways for STYXL1 Gene

No Data Available

Interacting Proteins for STYXL1 Gene

Gene Ontology (GO) - Biological Process for STYXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction TAS 9757831
genes like me logo Genes that share ontologies with STYXL1: view

No data available for Pathways by source and SIGNOR curated interactions for STYXL1 Gene

Drugs & Compounds for STYXL1 Gene

No Compound Related Data Available

Transcripts for STYXL1 Gene

Unigene Clusters for STYXL1 Gene

Serine/threonine/tyrosine interacting-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STYXL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: - - - -
SP6: -
SP7: - - - - - -
SP8:
SP9: - - -
SP10: -

Relevant External Links for STYXL1 Gene

GeneLoc Exon Structure for
STYXL1
ECgene alternative splicing isoforms for
STYXL1

Expression for STYXL1 Gene

mRNA expression in normal human tissues for STYXL1 Gene

SOURCE GeneReport for Unigene cluster for STYXL1 Gene Hs.11615

genes like me logo Genes that share expression patterns with STYXL1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for STYXL1 Gene

Orthologs for STYXL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STYXL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STYXL1 35
  • 98.72 (n)
  • 98.08 (a)
STYXL1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STYXL1 36
  • 75 (a)
OneToOne
STYXL1 35
  • 79.87 (n)
  • 76.3 (a)
dog
(Canis familiaris)
Mammalia STYXL1 35
  • 82.43 (n)
  • 77.64 (a)
STYXL1 36
  • 41 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Styxl1 36
  • 63 (a)
OneToOne
Styxl1 16
Styxl1 35
  • 73.7 (n)
  • 64.54 (a)
oppossum
(Monodelphis domestica)
Mammalia STYXL1 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STYXL1 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Styxl1 35
  • 75.43 (n)
  • 66.03 (a)
chicken
(Gallus gallus)
Aves STYXL1 36
  • 48 (a)
OneToOne
STYXL1 35
  • 59.16 (n)
  • 51.45 (a)
lizard
(Anolis carolinensis)
Reptilia STYXL1 36
  • 51 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32093 35
tropical clawed frog
(Silurana tropicalis)
Amphibia styxl1 35
  • 62.24 (n)
  • 53.06 (a)
zebrafish
(Danio rerio)
Actinopterygii styxl1 36
  • 40 (a)
OneToOne
styxl1 35
  • 53.06 (n)
  • 42.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for STYXL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STYXL1 Gene

ENSEMBL:
Gene Tree for STYXL1 (if available)
TreeFam:
Gene Tree for STYXL1 (if available)

Paralogs for STYXL1 Gene

(1) SIMAP similar genes for STYXL1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STYXL1: view

No data available for Paralogs for STYXL1 Gene

Variants for STYXL1 Gene

Sequence variations from dbSNP and Humsavar for STYXL1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs8565 -- 76,000,956(-) ACCCA(A/G)GGTAT intron-variant, reference, synonymous-codon, splice-acceptor-variant
rs1894812 -- 76,028,401(+) cagag(C/T)gagac intron-variant
rs2109718 -- 76,017,270(+) caccc(A/G)ccttg intron-variant
rs2159692 -- 76,037,707(+) CCCCC(A/C)AGACA intron-variant
rs2302434 -- 76,000,865(+) TGGTG(C/T)GAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STYXL1 Gene

Variant ID Type Subtype PubMed ID
nsv528969 CNV Gain 19592680
essv14753 CNV CNV 17122850
dgv120n16 CNV Deletion 17901297
dgv2103e1 CNV Complex 17122850
nsv428173 CNV Gain 18775914
dgv2104e1 CNV Complex 17122850
nsv888386 CNV Gain 21882294
nsv821252 CNV Deletion 20802225
nsv819156 CNV Gain 19587683
esv24008 CNV Gain+Loss 19812545
esv2734678 CNV Deletion 23290073
dgv1217e199 CNV Deletion 23128226
dgv1117n67 CNV Gain 20364138
esv2666194 CNV Deletion 23128226
dgv2105e1 CNV Complex 17122850

Variation tolerance for STYXL1 Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STYXL1 Gene

HapMap Linkage Disequilibrium report
STYXL1
Human Gene Mutation Database (HGMD)
STYXL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STYXL1 Gene

Disorders for STYXL1 Gene

Relevant External Links for STYXL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STYXL1

No disorders were found for STYXL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STYXL1 Gene

Publications for STYXL1 Gene

  1. Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains. (PMID: 9757831) Wishart M.J. … Dixon J.E. (Trends Biochem. Sci. 1998) 2 3 4 67
  2. The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation. (PMID: 20180778) Hinton S.D. … Tonks N.K. (Biochem. J. 2010) 3 23
  3. The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1. (PMID: 24709986) Niemi N.M. … MacKeigan J.P. (PLoS ONE 2014) 3
  4. The pseudophosphatase MK-STYX inhibits stress granule assembly independently of Ser149 phosphorylation of G3BP-1. (PMID: 23163895) Barr J.E. … Hinton S.D. (FEBS J. 2013) 3
  5. MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis. (PMID: 21262771) Niemi N.M. … MacKeigan J.P. (Mol. Cell. Biol. 2011) 3

Products for STYXL1 Gene

Sources for STYXL1 Gene

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