STYXL1 Gene
protein-coding GIFtS: 49
GCID: GC07M075625
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serine/threonine/tyrosine interacting-like 1(Previous name: dual specificity phosphatase 24 (putative) ) (Previous symbol: DUSP24)
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Aliases for STYXL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Serine/Threonine/Tyrosine Interacting-Like 11 2 | | Dual Specificity Protein Phosphatase 242 3 | | DUSP241 2 3 | | Map Kinase Phosphatase-Like Protein MK-STYX2 3 | | MK-STYX1 2 | | Serine/Threonine/Tyrosine-Interacting-Like Protein 12 | | Dual Specificity Phosphatase 24 (Putative)1 2 | | MKSTYX3 | | Dual Specificity Phosphatase Inhibitor MK-STYX2 3 | | |
Export aliases for STYXL1 gene to outside databasesPrevious GC identifers: GC07M075272 GC07M075463 GC07M070712 |
Summaries for STYXL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: STYL1_HUMAN, Q9Y6J8Function: Probable pseudophosphatase. Contains a Ser residue instead of a conserved Cys residue in the dsPTPasecatalytic loop which probably renders it catalytically inactive as a phosphatase. The binding pocket may be howeversufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases Gene Wiki entry for STYXL1
|
Genomic Views for STYXL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the STYXL1 gene promoter: ER-alpha GATA-3 Tal-1beta GATA-1 GATA-2 POU2F1 FOXO1a ITF-2 Pax-4a FOXO1 Other transcription factors
Search SABiosciences Chromatin IP Primers for STYXL1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STYXL1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23STYXL1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M075625: view genomic region
(about GC identifiers)
Start:
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75,625,655 bp from pter |
End:
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75,677,322 bp from pter |
Size:
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51,668 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 74,958,719-75,010,385 |
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Proteins for STYXL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: STYL1_HUMAN, Q9Y6J8 (See
protein sequence)Recommended Name: Serine/threonine/tyrosine-interacting-like protein 1 Size: 313 amino acids; 35818 Da
Secondary accessions: Q9UBP1 Q9UK06 Q9UK07 Q9UKG2 Q9UKG3Alternative splicing: 5 isoforms: Q9Y6J8-1 Q9Y6J8-2 Q9Y6J8-3 Q9Y6J8-4 Q9Y6J8-5 Explore the universe of human proteins at neXtProt for STYXL1: NX_Q9Y6J8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y6J8 STYXL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057170.1 ENSEMBL proteins: ENSP00000352726 ENSP00000343383 ENSP00000403033 ENSP00000404495 ENSP00000392221 ENSP00000406073 ENSP00000411812 ENSP00000248600 ENSP00000353798 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- |
STYXL1 for ontologies About GeneDecksing
STYXL1 Antibody Products: Assay Products for STYXL1: |
Protein
Domains / Families for STYXL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STYXL1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y6J8ProtoNet protein and cluster: Q9Y6J8 2 Blocks protein families: IPB000340 Dual specificity protein phosphatase IPB001763 Rhodanese-like
UniProtKB/Swiss-Prot: STYL1_HUMAN, Q9Y6J8Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamilySimilarity: Contains 1 rhodanese domainSimilarity: Contains 1 tyrosine-protein phosphatase domain |
Function for STYXL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: STYL1_HUMAN, Q9Y6J8Function: Probable pseudophosphatase. Contains a Ser residue instead of a conserved Cys residue in the dsPTPasecatalytic loop which probably renders it catalytically inactive as a phosphatase. The binding pocket may be howeversufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STYXL1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STYXL1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: STYXL1 (NM_016086) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STYXL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STYXL1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STYXL1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008138 | NOT protein tyrosine/serine/threonine phosphatase activity |
IKR | -- |
STYXL1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for STYXL1:
|
Pathways & Interactions for STYXL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STYXL1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
 5/14 Interacting proteins for STYXL1 (Q9Y6J83 ENSP000002486004) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006470 | NOT protein dephosphorylation |
IKR | -- | | GO:0035556 | intracellular signal transduction |
TAS | 9757831 |
STYXL1 for ontologies About GeneDecksing
|
Drugs & Compounds for STYXL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for STYXL1 Search CenterWatch for drugs/clinical trials and news about STYXL1 / STYL1 
|
Transcripts for STYXL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for STYXL1 gene: NM_016086.2 Unigene Cluster for STYXL1: Serine/threonine/tyrosine interacting-like 1 Hs.11615 [show with all ESTs]Unigene Representative Sequence: AK30891211 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000359697 ENST00000340062 ENST00000430497 ENST00000438695 ENST00000431581(uc003uen.1) ENST00000454618 ENST00000451157(uc010ldg.2 uc010ldh.2) ENST00000474328 ENST00000460184 ENST00000248600(uc003uef.3 uc011kgg.2 uc003ueh.3 uc011kgf.2 uc003uek.4 uc003uel.3 uc003uem.3) ENST00000360591
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STYXL1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STYXL1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: STYXL1 (NM_016086) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STYXL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STYXL1  |
Additional cDNA sequence: AF069762.1 AF169647.1 AF169648.1 AF188201.1 AF188202.1 AF188203.1 AF188204.1 AK308828.1 AK308912.1 AY927581.1 BC024035.2 BX537896.1 24/25 DOTS entries (see all 25): DT.121059080 DT.100815749 DT.121058992 DT.454240 DT.97811052 DT.99934494 DT.92028328 DT.100815753 DT.100815751 DT.121058999 DT.121058860 DT.121058865 DT.121058986 DT.100815746 DT.121058944 DT.121059038 DT.92432633 DT.95163674 DT.121058851 DT.121058961 DT.40259737 DT.92432631 DT.100815755 DT.121058935 24/367 AceView cDNA sequences (see all 367): CA423417 AA470406 CR609218 CR614474 AA477639 BM674401 BM701267 AF188203 BM966994 NM_031925 CR605601 BU630357 AI092561 CK906121 BM726249 BU632819 CA309269 AF188201 BM927937 CR611494 CD370390 CR615380 BQ233752 CR606386 GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for STYXL1 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for STYXL1
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Expression for STYXL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STYXL1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GATCCGCTCT
About this image See STYXL1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for STYXL1
SOURCE GeneReport for Unigene cluster: Hs.11615 SABiosciences Custom PCR Arrays for STYXL1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STYXL1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STYXL1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STYXL1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STYXL1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STYXL1 |
Orthologs for STYXL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for STYXL1 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for STYXL1 (if available) TreeFam Gene Tree for STYXL1 (if available)  |
Paralogs for STYXL1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for STYXL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 7 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for STYXL1 (75625655 - 75677322 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for STYXL1 4 CNVs: 3686 59422 22956 64865  | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases for STYXL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STYXL1 for disorders About GeneDecksing
1 disease for STYXL1: About MalaCardssarcoma Export disorders for STYXL1 gene to outside databases
|
Publications for STYXL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STYXL1 gene, integrated from 9 sources (see all 13): (articles sorted by number of sources associating them with STYXL1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains. (PubMed id 9757831)1, 2, 3 Wishart M.J. and Dixon J.E. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation. (PubMed id 20180778)1, 9 Hinton S.D....Tonks N.K. (2010)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- MK-STYX, a catalytically inactive phosphatase regulat ing mitochondrially dependent apoptosis. (PubMed id 21262771)1 Niemi N.M....MacKeigan J.P. (2011)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin. (PubMed id 15735734)1 Siligan C....Kovar H. (2005)
- High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
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External Searches for STYXL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing STYXL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STYXL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STYXL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for STYXL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STYXL1 gene: Search GeneIP for patents involving STYXL1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for STYXL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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 | |
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| |  |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STYXL1 | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STYXL1 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STYXL1 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STYXL1 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STYXL1 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STYXL1 |
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| | | Search Tocris compounds for STYXL1 |
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 | | STYXL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STYXL1 |
|  |  |  | | | ThermoFisher Antibody for STYXL1 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STYXL1 |
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