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STYX Gene

protein-coding   GIFtS: 51
GCID: GC14P053196

Serine/Threonine/Tyrosine Interacting Protein

(Previous name: serine/threonine/tyrosine-interacting protein)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Threonine/Tyrosine Interacting Protein1 2
Serine/Threonine/Tyrosine-Interacting Protein1 2
Protein Tyrosine Phosphatase-Like Protein2 3

External Ids:    HGNC: 114471   Entrez Gene: 68152   Ensembl: ENSG000001982527   UniProtKB: Q8WUJ03   

Export aliases for STYX gene to outside databases

Previous GC identifers: GC00U990358 GC14P046992 GC14P051186 GC14P052266 GC14P033357


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STYX Gene:
The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active
catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same
protein have been found for these genes. (provided by RefSeq, Oct 2011)

GeneCards Summary for STYX Gene:
STYX (serine/threonine/tyrosine interacting protein) is a protein-coding gene. An important paralog of this gene is DUSP26.

UniProtKB/Swiss-Prot: STYX_HUMAN, Q8WUJ0
Function: Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase
catalytic loop which renders it catalytically inactive as a phosphatase. The binding pocket is however
sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Seems to play
a role in spermiogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STYX gene promoter:
         AREB6   MEF-2A   Nkx6-1   Bach2   FOXD1   CUTL1   aMEF-2   HNF-3beta   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTYX promoter sequence
   Search Chromatin IP Primers for STYX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STYX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q22.1

STYX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STYX gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P053196:  view genomic region     (about GC identifiers)

Start:
53,196,883 bp from pter      End:
53,241,716 bp from pter
Size:
44,834 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STYX_HUMAN, Q8WUJ0 (See protein sequence)
Recommended Name: Serine/threonine/tyrosine-interacting protein  
Size: 223 amino acids; 25492 Da
Subunit: Interacts with CARHSP1/Crhsp-24 (By similarity)
1 PDB 3D structure from and Proteopedia for STYX:
2R0B (3D)    
Secondary accessions: B9EJG0 Q99850

Explore the universe of human proteins at neXtProt for STYX: NX_Q8WUJ0

Explore proteomics data for STYX at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STYX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001124173.1  NP_660294.1  

    ENSEMBL proteins: 
     ENSP00000403214   ENSP00000346599  

    STYX Human Recombinant Protein Products:

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    Novus Biologicals STYX Proteins
    Novus Biologicals STYX Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for STYX
    Cloud-Clone Corp. Proteins for STYX

     
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    STYX Antibody Products:

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    LSBio Antibodies in human, mouse, rat for STYX

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPA: Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

    4 InterPro protein domains:
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR024950 DUSP
     IPR000340 Dual-sp_phosphatase_cat-dom

    Graphical View of Domain Structure for InterPro Entry Q8WUJ0

    ProtoNet protein and cluster: Q8WUJ0

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: STYX_HUMAN, Q8WUJ0
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with STYX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STYX_HUMAN, Q8WUJ0
    Function: Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase
    catalytic loop which renders it catalytically inactive as a phosphatase. The binding pocket is however
    sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Seems to play
    a role in spermiogenesis (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008138NOT protein tyrosine/serine/threonine phosphatase activity IKR--
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with STYX           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STYX:
     Decreased G3BP1 protein expres 

         1 MGI mutant phenotype (inferred from 3 alleles(MGI details for Styx):
     reproductive system 

    Find genes that share phenotypes with STYX           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Styxtm1.1Jedi for STYX

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STYX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STYX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STYX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STYX

    miRNA
    Products:
        
    miRTarBase miRNAs that target STYX:
    hsa-mir-93-5p (MIRT028126), hsa-mir-33a-5p (MIRT028243), hsa-mir-130b-3p (MIRT020255), hsa-mir-32-5p (MIRT028363)

    Block miRNA regulation of human, mouse, rat STYX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STYX (see all 145):
    hsa-miR-106a hsa-miR-3074-3p hsa-miR-519a hsa-miR-4275 hsa-miR-298 hsa-miR-200b hsa-miR-92b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidSTYX 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STYX

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for STYX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): STYX (NM_001130701)
    Sino Biological Human cDNA Clone for STYX
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STYX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STYX

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for STYX 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STYX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--

    Find genes that share ontologies with STYX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STYX
    Interactions:

        GeneGlobe Interaction Network for STYX

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for STYX (Q8WUJ03 ENSP000003465994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CARHSP1Q9Y2V23, ENSP000003118474I2D: score=2 STRING: ENSP00000311847
    MRTO4ENSP000003643204STRING: ENSP00000364320
    MOB1AENSP000003793644STRING: ENSP00000379364
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470NOT protein dephosphorylation IKR--
    GO:0007283spermatogenesis IBA--
    GO:0016311dephosphorylation ----

    Find genes that share ontologies with STYX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STYX

    4 Novoseek inferred chemical compound relationships for STYX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 68.2 35 10644438 (2), 11054553 (2), 10333047 (2), 8826969 (1) (see all 29)
    c-peptide 45.8 1 12017227 (1)
    glutamate 45.5 7 10333047 (2), 12017227 (1), 15804058 (1), 11061548 (1) (see all 6)
    glucose 0 2 10333047 (2)



    Find genes that share compounds with STYX           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STYX gene (2 alternative transcripts): 
    NM_001130701.1  NM_145251.3  

    Unigene Cluster for STYX:

    Serine/threonine/tyrosine interacting protein
    Hs.364980  [show with all ESTs]
    Unigene Representative Sequence: NM_145251
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442123 ENST00000354586(uc010tqy.2 uc001xaa.3) ENST00000556861

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STYX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STYX (see all 145):
    hsa-miR-106a hsa-miR-3074-3p hsa-miR-519a hsa-miR-4275 hsa-miR-298 hsa-miR-200b hsa-miR-92b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidSTYX 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for STYX
    Predesigned siRNA for gene silencing in human, mouse, rat STYX
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): STYX (NM_001130701)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STYX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STYX
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    OriGene qSTAR qPCR primer pairs in human, mouse for STYX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STYX
      QuantiTect SYBR Green Assays in human, mouse, rat STYX
      QuantiFast Probe-based Assays in human, mouse, rat STYX

    Additional mRNA sequence: 

    AF085865.1 AK098195.1 AK124924.1 AL832591.1 AL832697.1 BC020265.2 BC146995.1 BC146998.1 
    BX647636.1 U87169.1 

    7 DOTS entries:

    DT.310087  DT.407473  DT.91734922  DT.97822819  DT.100750203  DT.100806674  DT.100036140 

    Selected AceView cDNA sequences (see all 100):

    AA789071 AA761314 AA488895 NM_145251 CA437823 AI742206 U87169 N44194 
    BC020265 AA488966 BU154927 BM800458 CK904386 BG391583 AA761329 AK098195 
    AI243613 CF121970 AI492892 BX646609 BG681149 H29947 BQ082024 CF137983 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for STYX    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                                  
    SP2:                                                                  


    ECgene alternative splicing isoforms for STYX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STYX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    STYX Expression
    About this image

    STYX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STYX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.364980
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STYX gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Styx1 , 5 serine/threonine/tyrosine interaction protein1, 5 91.33(n)1
    96.41(a)1
      14 (22.90 cM)5
    562911  NM_019637.31  NP_062611.21 
     453514735 
    chicken
    (Gallus gallus)
    Aves STYX1 serine/threonine/tyrosine interacting protein 86.43(n)
    91.96(a)
      423587  XM_421475.4  XP_421475.3 
    lizard
    (Anolis carolinensis)
    Reptilia STYX6
    serine/threonine/tyrosine interacting protein
    88(a)
    1 ↔ 1
    GL343527.1(34642-68916)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.254992 Xenopus laevis transcribed sequence with weak similarity more 80.91(n)    CA972273.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570437572   -- 73.47(n)    57043757 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54F10BM.136
    Protein Y54F10BM.13 (Y54F10BM.13) mRNA, complete c...
    29(a)
    1 ↔ 1
    III(2329583-2331183) WBGene00021867


    ENSEMBL Gene Tree for STYX (if available)
    TreeFam Gene Tree for STYX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STYX gene
    DUSP262  DUSP212  DUPD12  DUSP32  DUSP132  DUSP272  DUSP142  DUSP192  
    DUSP282  DUSP152  DUSP222  DUSP182  
    4 SIMAP similar genes for STYX using alignment to 1 protein entry:     STYX_HUMAN:
    DUSP8    DUSP22    DUSP19    DUSP9

    Find genes that share paralogs with STYX           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STYX (see all 884)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22737431,2
    C,F,O,A,H--34178294(+) ATGTGA/GAGGTC 2 -- us2k128Minor allele frequency- G:0.31NA NS EA WA CSA 2663
    rs349809441,2
    C,F,H--34178389(+) AAGGAC/TTCTTT 2 -- us2k111Minor allele frequency- T:0.01NS NA 1504
    rs170930151,2
    C,F,H--34178668(+) ACTTCC/TTAGCA 2 -- us2k111Minor allele frequency- T:0.03NA EA NS 1230
    rs1907368471,2
    --34178939(+) ATCAAC/TTTGGT 2 -- us2k10--------
    rs1826096211,2
    C--34178944(+) TTTGGC/TGTACA 2 -- us2k10--------
    rs101468731,2
    C,F,A,H--34179017(+) AGGCTG/ATAGTG 2 -- us2k113Minor allele frequency- A:0.03NS EA NA WA CSA 420
    rs1454731981,2
    C--34179048(+) ATTGCA/TACCTC 2 -- us2k10--------
    rs101468261,2
    C,F,A,H--34179165(+) GGTTTC/TTCCAT 2 -- us2k18Minor allele frequency- T:0.50NA WA CSA 18
    rs20650501,2
    C,F--34179225(+) cagccG/Tcccaa 2 -- us2k1 tfbs31Minor allele frequency- T:0.50CSA 2
    rs284121201,2
    C,F--34179248(+) ACAGGG/CGTGAG 2 -- us2k12Minor allele frequency- C:0.50WA CSA 4

    HapMap Linkage Disequilibrium report for STYX (53196883 - 53241716 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for STYX:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1279CNV Insertion18451855
    nsv901952CNV Loss21882294
    nsv832796CNV Loss17160897
    nsv470647CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STYX
    DNA2.0 Custom Variant and Variant Library Synthesis for STYX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for STYX:
    Echinococcosis

    Find genes that share disorders with STYX           About GenesLikeMe

    4 Novoseek inferred disease relationships for STYX gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulinoma 64.1 1 9588444 (1)
    autoimmunity 57 1 19120305 (1)
    diabetes autoimmune 47.6 1 15155543 (1)
    diabetes mellitus insulin-dependent 32.7 2 9389426 (1), 9605631 (1)

    Genetic Association Database (GAD): STYX
    Human Genome Epidemiology (HuGE) Navigator: STYX (1 document)

    Export disorders for STYX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STYX gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with STYX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase. (PubMed id 7592916)1, 3, 9 Wishart M.J....Dixon J.E. (J. Biol. Chem. 1995)
    2. Identification of potentially damaging amino acid substitutions leading to human male infertility. (PubMed id 19369647)1, 4 Kuzmin A....Varmuza S. (Biol. Reprod. 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38. (PubMed id 9633825)1, 2 Dayton M.A. and Knobloch T.J. (Recept. Signal Transduct. 1997)
    6. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PubMed id 24035498)1 Tan M.K....Harper J.W. (Mol. Cell 2013)
    7. Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2. (PubMed id 23847209)1 Reiterer V....Farhan H. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    8. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    9. Structural genomics of protein phosphatases. (PubMed id 18058037)2 Almo S.C.... Burley S.K. (J. Struct. Funct. Genomics 2007)
    10. Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. (PubMed id 17047026)1 Yatsenko A.N....Matzuk M.M. (Hum. Mol. Genet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6815 HGNC: 11447 AceView: STYX Ensembl:ENSG00000198252 euGenes: HUgn6815
    ECgene: STYX H-InvDB: STYX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STYX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STYX gene:
    Search GeneIP for patents involving STYX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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