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Aliases for STYX Gene

Aliases for STYX Gene

  • Serine/Threonine/Tyrosine Interacting Protein 2 3
  • Serine/Threonine/Tyrosine-Interacting Protein 2
  • Protein Tyrosine Phosphatase-Like Protein 4

External Ids for STYX Gene

Previous GeneCards Identifiers for STYX Gene

  • GC00U990358
  • GC14P046992
  • GC14P051186
  • GC14P052266
  • GC14P053196
  • GC14P033357

Summaries for STYX Gene

Entrez Gene Summary for STYX Gene

  • The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011]

GeneCards Summary for STYX Gene

STYX (Serine/Threonine/Tyrosine Interacting Protein) is a Protein Coding gene. An important paralog of this gene is DUSP26.

UniProtKB/Swiss-Prot for STYX Gene

  • Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). Seems to play a role in spermiogenesis (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STYX Gene

Genomics for STYX Gene

Regulatory Elements for STYX Gene

Genomic Location for STYX Gene

52,730,165 bp from pter
52,774,998 bp from pter
44,834 bases
Plus strand

Genomic View for STYX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STYX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STYX Gene

Proteins for STYX Gene

  • Protein details for STYX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine/tyrosine-interacting protein
    Protein Accession:
    Secondary Accessions:
    • B9EJG0
    • Q99850

    Protein attributes for STYX Gene

    223 amino acids
    Molecular mass:
    25492 Da
    Quaternary structure:
    • Interacts with MAPK1; independently of MAPK1 phosphorylation status. Interacts with CARHSP1/Crhsp-24 (By similarity).
    • Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase. The binding pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases

    Three dimensional structures from OCA and Proteopedia for STYX Gene

neXtProt entry for STYX Gene

Proteomics data for STYX Gene at MOPED

Post-translational modifications for STYX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STYX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STYX Gene

Domains for STYX Gene

Gene Families for STYX Gene

  • DUSPA :Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

Suggested Antigen Peptide Sequences for STYX Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8WUJ0
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with STYX: view

Function for STYX Gene

Molecular function for STYX Gene

UniProtKB/Swiss-Prot Function: Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). Seems to play a role in spermiogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for STYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23847209
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with STYX: view

Phenotypes for STYX Gene

genes like me logo Genes that share phenotypes with STYX: view

Animal Models for STYX Gene

MGI Knock Outs for STYX:

miRNA for STYX Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for STYX Gene

Localization for STYX Gene

Subcellular locations from UniProtKB/Swiss-Prot for STYX Gene

Nucleus. Cytoplasm, cytosol. Note=Little staining visible in the cytosol.

Subcellular locations from

Jensen Localization Image for STYX Gene COMPARTMENTS Subcellular localization image for STYX gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for STYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23847209
GO:0005737 cytoplasm IDA 23847209
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with STYX: view

Pathways for STYX Gene

SuperPathways for STYX Gene

No Data Available

Gene Ontology (GO) - Biological Process for STYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0007283 spermatogenesis IBA --
GO:0016311 dephosphorylation --
GO:0045204 MAPK export from nucleus IMP 23847209
GO:0070372 regulation of ERK1 and ERK2 cascade IMP 23847209
genes like me logo Genes that share ontologies with STYX: view

No data available for Pathways by source for STYX Gene

Compounds for STYX Gene

(4) Novoseek inferred chemical compound relationships for STYX Gene

Compound -log(P) Hits PubMed IDs
tyrosine 68.2 32
c-peptide 45.8 1
glutamate 45.5 7
glucose 0 2
genes like me logo Genes that share compounds with STYX: view

Transcripts for STYX Gene

Unigene Clusters for STYX Gene

Serine/threonine/tyrosine interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STYX Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b

Relevant External Links for STYX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STYX Gene

mRNA expression in normal human tissues for STYX Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STYX Gene

SOURCE GeneReport for Unigene cluster for STYX Gene Hs.364980

genes like me logo Genes that share expressions with STYX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STYX Gene

Orthologs for STYX Gene

This gene was present in the common ancestor of animals.

Orthologs for STYX Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STYX 35
  • 99.85 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia STYX 35
  • 94.32 (n)
  • 97.31 (a)
  • 97 (a)
(Canis familiaris)
Mammalia STYX 35
  • 93.72 (n)
  • 96.41 (a)
  • 89 (a)
(Mus musculus)
Mammalia Gm14698 36
  • 96 (a)
Styx 35
  • 91.33 (n)
  • 96.41 (a)
Styx 16
Styx 36
  • 96 (a)
(Monodelphis domestica)
Mammalia STYX 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia STYX 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Styx 35
  • 91.48 (n)
  • 95.96 (a)
(Gallus gallus)
Aves -- 36
  • 25 (a)
  • 86.43 (n)
  • 91.96 (a)
(Anolis carolinensis)
Reptilia STYX 36
  • 88 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25499 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6090 35
styx 35
  • 81.32 (n)
  • 85.2 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2014 35
(Danio rerio)
Actinopterygii styx 35
  • 72.82 (n)
  • 77.93 (a)
styx 36
  • 78 (a)
(Caenorhabditis elegans)
Secernentea Y54F10BM.13 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for STYX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STYX Gene

Gene Tree for STYX (if available)
Gene Tree for STYX (if available)

Paralogs for STYX Gene

Selected SIMAP similar genes for STYX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STYX: view

Variants for STYX Gene

Sequence variations from dbSNP and Humsavar for STYX Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs722290 -- 52,750,005(-) ATACT(C/G)AGATG intron-variant
rs1141518 -- 52,762,882(+) TCTTT(A/C/T)TTTTT intron-variant
rs1254972 -- 52,742,898(+) tcaag(C/T)gattc intron-variant
rs1254973 -- 52,744,412(+) TTTAT(A/C)CATTT intron-variant
rs1254974 -- 52,744,496(+) TTGAT(C/T)AGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STYX Gene

Variant ID Type Subtype PubMed ID
nsv832796 CNV Loss 17160897
nsv470647 CNV Gain 18288195
nsv901952 CNV Loss 21882294
nsv1279 CNV Insertion 18451855

Relevant External Links for STYX Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STYX Gene

Disorders for STYX Gene

(1) University of Copenhagen DISEASES for STYX Gene

(4) Novoseek inferred disease relationships for STYX Gene

Disease -log(P) Hits PubMed IDs
insulinoma 64.1 1
autoimmunity 57 1
diabetes autoimmune 47.6 1
diabetes mellitus insulin-dependent 32.7 2

Relevant External Links for STYX

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with STYX: view

No data available for UniProtKB/Swiss-Prot for STYX Gene

Publications for STYX Gene

  1. A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase. (PMID: 7592916) Wishart M.J. … Dixon J.E. (J. Biol. Chem. 1995) 2 3 23
  2. Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38. (PMID: 9633825) Dayton M.A. … Knobloch T.J. (Recept. Signal Transduct. 1997) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of potentially damaging amino acid substitutions leading to human male infertility. (PMID: 19369647) Kuzmin A. … Varmuza S. (Biol. Reprod. 2009) 3 48

Products for STYX Gene

Sources for STYX Gene

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