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Aliases for STYX Gene

Aliases for STYX Gene

  • Serine/Threonine/Tyrosine Interacting Protein 2 3 5
  • Serine/Threonine/Tyrosine-Interacting Protein 2
  • Protein Tyrosine Phosphatase-Like Protein 4

External Ids for STYX Gene

Previous GeneCards Identifiers for STYX Gene

  • GC00U990358
  • GC14P046992
  • GC14P051186
  • GC14P052266
  • GC14P053196
  • GC14P033357

Summaries for STYX Gene

Entrez Gene Summary for STYX Gene

  • The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011]

GeneCards Summary for STYX Gene

STYX (Serine/Threonine/Tyrosine Interacting Protein) is a Protein Coding gene. Diseases associated with STYX include Diabetes Mellitus, Insulin-Dependent. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP27.

UniProtKB/Swiss-Prot for STYX Gene

  • Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). Seems to play a role in spermiogenesis (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STYX Gene

Genomics for STYX Gene

Regulatory Elements for STYX Gene

Enhancers for STYX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G052699 1.1 Ensembl ENCODE 29.5 -29.3 -29304 2.6 ELF3 HNRNPUL1 FOXA2 ARID4B DMAP1 YY1 RARA ZNF335 SLC30A9 FOS STYX ERO1A PSMC6
GH14G052729 1.1 ENCODE 24.8 +0.2 166 2.2 HDGF PKNOX1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 STYX ENSG00000259049
GH14G052789 1.1 ENCODE 22.2 +61.2 61184 3.2 HNRNPUL1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 STYX ENSG00000237356 GNPNAT1 GC14P052785
GH14G052706 1 ENCODE 22.8 -22.8 -22841 2.4 HDGF PKNOX1 ARNT SIN3A DMAP1 ZNF48 YY1 ETS1 ZNF766 GATA2 STYX PSMC6
GH14G052702 0.9 Ensembl ENCODE 25.1 -26.7 -26656 1.3 TBP MAX CEBPB EP300 ATF2 JUND CEBPA STAT3 CREB1 FOS STYX PSMC6 ERO1A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STYX on UCSC Golden Path with GeneCards custom track

Promoters for STYX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000068454 335 1801 HDGF PKNOX1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for STYX Gene

Chromosome:
14
Start:
52,730,165 bp from pter
End:
52,774,998 bp from pter
Size:
44,834 bases
Orientation:
Plus strand

Genomic View for STYX Gene

Genes around STYX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STYX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STYX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STYX Gene

Proteins for STYX Gene

  • Protein details for STYX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUJ0-STYX_HUMAN
    Recommended name:
    Serine/threonine/tyrosine-interacting protein
    Protein Accession:
    Q8WUJ0
    Secondary Accessions:
    • B9EJG0
    • Q99850

    Protein attributes for STYX Gene

    Size:
    223 amino acids
    Molecular mass:
    25492 Da
    Quaternary structure:
    • Interacts with MAPK1; independently of MAPK1 phosphorylation status. Interacts with CARHSP1/Crhsp-24 (By similarity).
    Miscellaneous:
    • Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase. The binding pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases.

    Three dimensional structures from OCA and Proteopedia for STYX Gene

neXtProt entry for STYX Gene

Post-translational modifications for STYX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STYX Gene

No data available for DME Specific Peptides for STYX Gene

Domains & Families for STYX Gene

Gene Families for STYX Gene

Suggested Antigen Peptide Sequences for STYX Gene

Graphical View of Domain Structure for InterPro Entry

Q8WUJ0

UniProtKB/Swiss-Prot:

STYX_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with STYX: view

Function for STYX Gene

Molecular function for STYX Gene

UniProtKB/Swiss-Prot Function:
Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). Seems to play a role in spermiogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for STYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23847209
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with STYX: view
genes like me logo Genes that share phenotypes with STYX: view

Animal Models for STYX Gene

MGI Knock Outs for STYX:

Animal Model Products

  • Taconic Biosciences Mouse Models for STYX

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STYX Gene

Localization for STYX Gene

Subcellular locations from UniProtKB/Swiss-Prot for STYX Gene

Nucleus. Cytoplasm, cytosol. Note=Little staining visible in the cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STYX gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for STYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 23847209
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 23847209
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with STYX: view

Pathways & Interactions for STYX Gene

No Data Available

Gene Ontology (GO) - Biological Process for STYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0007283 spermatogenesis IBA --
GO:0016311 dephosphorylation IEA --
GO:0045204 MAPK export from nucleus IMP 23847209
GO:0070372 regulation of ERK1 and ERK2 cascade IMP 23847209
genes like me logo Genes that share ontologies with STYX: view

No data available for Pathways by source and SIGNOR curated interactions for STYX Gene

Drugs & Compounds for STYX Gene

(2) Drugs for STYX Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for STYX Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STYX: view

Transcripts for STYX Gene

Unigene Clusters for STYX Gene

Serine/threonine/tyrosine interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for STYX Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1:
SP2:

Relevant External Links for STYX Gene

GeneLoc Exon Structure for
STYX
ECgene alternative splicing isoforms for
STYX

Expression for STYX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STYX Gene

Protein differential expression in normal tissues from HIPED for STYX Gene

This gene is overexpressed in Heart (35.5), CD8 Tcells (16.2), and Testis (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STYX Gene



Protein tissue co-expression partners for STYX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STYX Gene:

STYX

SOURCE GeneReport for Unigene cluster for STYX Gene:

Hs.364980

Evidence on tissue expression from TISSUES for STYX Gene

  • Heart(4.2)
  • Lung(4.2)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with STYX: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STYX Gene

Orthologs for STYX Gene

This gene was present in the common ancestor of animals.

Orthologs for STYX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STYX 34 35
  • 99.85 (n)
mouse
(Mus musculus)
Mammalia Gm14698 35
  • 96 (a)
OneToMany
Styx 34 16 35
  • 91.33 (n)
cow
(Bos Taurus)
Mammalia STYX 34 35
  • 94.32 (n)
dog
(Canis familiaris)
Mammalia STYX 34 35
  • 93.72 (n)
rat
(Rattus norvegicus)
Mammalia Styx 34
  • 91.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STYX 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STYX 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves STYX 34
  • 86.43 (n)
-- 35
  • 25 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia STYX 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia styx 34
  • 81.32 (n)
Str.6090 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25499 34
zebrafish
(Danio rerio)
Actinopterygii styx 34 35
  • 72.82 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2014 34
worm
(Caenorhabditis elegans)
Secernentea Y54F10BM.13 35
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToOne
Species where no ortholog for STYX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STYX Gene

ENSEMBL:
Gene Tree for STYX (if available)
TreeFam:
Gene Tree for STYX (if available)

Paralogs for STYX Gene

(4) SIMAP similar genes for STYX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STYX: view

Variants for STYX Gene

Sequence variations from dbSNP and Humsavar for STYX Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000054381 -- 52,761,242(+) AGAAT(C/T)GCTTG intron-variant
rs1000094738 -- 52,770,880(+) GGTAA(A/T)TTATC intron-variant
rs1000109847 -- 52,760,870(+) GCATG(C/T)AATGT intron-variant
rs1000196420 -- 52,774,326(+) AATTA(C/T)AAAGT utr-variant-3-prime
rs1000228518 -- 52,731,185(+) ACTCG(G/T)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STYX Gene

Variant ID Type Subtype PubMed ID
nsv1050582 CNV gain 25217958
nsv1279 CNV insertion 18451855
nsv470647 CNV gain 18288195
nsv832796 CNV loss 17160897

Variation tolerance for STYX Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STYX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STYX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STYX Gene

Disorders for STYX Gene

MalaCards: The human disease database

(1) MalaCards diseases for STYX Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, insulin-dependent
  • diabetes, type 1
- elite association - COSMIC cancer census association via MalaCards
Search STYX in MalaCards View complete list of genes associated with diseases

Relevant External Links for STYX

Genetic Association Database (GAD)
STYX
Human Genome Epidemiology (HuGE) Navigator
STYX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STYX
genes like me logo Genes that share disorders with STYX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STYX Gene

Publications for STYX Gene

  1. A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase. (PMID: 7592916) Wishart M.J. … Dixon J.E. (J. Biol. Chem. 1995) 2 3 22 64
  2. Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2. (PMID: 23847209) Reiterer V. … Farhan H. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4 64
  3. Identification of potentially damaging amino acid substitutions leading to human male infertility. (PMID: 19369647) Kuzmin A. … Varmuza S. (Biol. Reprod. 2009) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for STYX Gene

Sources for STYX Gene

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