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Aliases for STYX Gene

Aliases for STYX Gene

  • Serine/Threonine/Tyrosine Interacting Protein 2 3 5
  • Serine/Threonine/Tyrosine-Interacting Protein 2
  • Protein Tyrosine Phosphatase-Like Protein 4

External Ids for STYX Gene

Previous GeneCards Identifiers for STYX Gene

  • GC00U990358
  • GC14P046992
  • GC14P051186
  • GC14P052266
  • GC14P053196
  • GC14P033357

Summaries for STYX Gene

Entrez Gene Summary for STYX Gene

  • The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011]

GeneCards Summary for STYX Gene

STYX (Serine/Threonine/Tyrosine Interacting Protein) is a Protein Coding gene. Diseases associated with STYX include diabetes mellitus, insulin-dependent. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP15.

UniProtKB/Swiss-Prot for STYX Gene

  • Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). Seems to play a role in spermiogenesis (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STYX Gene

Genomics for STYX Gene

Regulatory Elements for STYX Gene

Enhancers for STYX Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STYX on UCSC Golden Path with GeneCards custom track

Promoters for STYX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STYX on UCSC Golden Path with GeneCards custom track

Genomic Location for STYX Gene

Chromosome:
14
Start:
52,730,165 bp from pter
End:
52,774,998 bp from pter
Size:
44,834 bases
Orientation:
Plus strand

Genomic View for STYX Gene

Genes around STYX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STYX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STYX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STYX Gene

Proteins for STYX Gene

  • Protein details for STYX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUJ0-STYX_HUMAN
    Recommended name:
    Serine/threonine/tyrosine-interacting protein
    Protein Accession:
    Q8WUJ0
    Secondary Accessions:
    • B9EJG0
    • Q99850

    Protein attributes for STYX Gene

    Size:
    223 amino acids
    Molecular mass:
    25492 Da
    Quaternary structure:
    • Interacts with MAPK1; independently of MAPK1 phosphorylation status. Interacts with CARHSP1/Crhsp-24 (By similarity).
    Miscellaneous:
    • Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase. The binding pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases.

    Three dimensional structures from OCA and Proteopedia for STYX Gene

neXtProt entry for STYX Gene

Proteomics data for STYX Gene at MOPED

Post-translational modifications for STYX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STYX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STYX Gene

Domains & Families for STYX Gene

Gene Families for STYX Gene

Suggested Antigen Peptide Sequences for STYX Gene

Graphical View of Domain Structure for InterPro Entry

Q8WUJ0

UniProtKB/Swiss-Prot:

STYX_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with STYX: view

Function for STYX Gene

Molecular function for STYX Gene

UniProtKB/Swiss-Prot Function:
Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). Seems to play a role in spermiogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for STYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23847209
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with STYX: view
genes like me logo Genes that share phenotypes with STYX: view

Animal Models for STYX Gene

MGI Knock Outs for STYX:

Animal Model Products

  • Taconic Biosciences Mouse Models for STYX

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STYX Gene

Localization for STYX Gene

Subcellular locations from UniProtKB/Swiss-Prot for STYX Gene

Nucleus. Cytoplasm, cytosol. Note=Little staining visible in the cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STYX Gene COMPARTMENTS Subcellular localization image for STYX gene
Compartment Confidence
cytosol 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for STYX Gene

Pathways & Interactions for STYX Gene

SuperPathways for STYX Gene

No Data Available

Gene Ontology (GO) - Biological Process for STYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0045204 MAPK export from nucleus IMP 23847209
GO:0070372 regulation of ERK1 and ERK2 cascade IMP 23847209
genes like me logo Genes that share ontologies with STYX: view

No data available for Pathways by source and SIGNOR curated interactions for STYX Gene

Drugs & Compounds for STYX Gene

(1) Drugs for STYX Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for STYX Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STYX: view

Transcripts for STYX Gene

Unigene Clusters for STYX Gene

Serine/threonine/tyrosine interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STYX Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1:
SP2:

Relevant External Links for STYX Gene

GeneLoc Exon Structure for
STYX
ECgene alternative splicing isoforms for
STYX

Expression for STYX Gene

mRNA expression in normal human tissues for STYX Gene

Protein differential expression in normal tissues from HIPED for STYX Gene

This gene is overexpressed in Heart (35.5), CD8 Tcells (16.2), and Testis (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STYX Gene



SOURCE GeneReport for Unigene cluster for STYX Gene Hs.364980

genes like me logo Genes that share expression patterns with STYX: view

Protein tissue co-expression partners for STYX Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STYX Gene

Orthologs for STYX Gene

This gene was present in the common ancestor of animals.

Orthologs for STYX Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STYX 35
  • 94.32 (n)
  • 97.31 (a)
STYX 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STYX 35
  • 93.72 (n)
  • 96.41 (a)
STYX 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Styx 35
  • 91.33 (n)
  • 96.41 (a)
Styx 16
Gm14698 36
  • 96 (a)
OneToMany
Styx 36
  • 96 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia STYX 35
  • 99.85 (n)
  • 100 (a)
STYX 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Styx 35
  • 91.48 (n)
  • 95.96 (a)
oppossum
(Monodelphis domestica)
Mammalia STYX 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STYX 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves STYX 35
  • 86.43 (n)
  • 91.96 (a)
-- 36
  • 25 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia STYX 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6090 35
styx 35
  • 81.32 (n)
  • 85.2 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25499 35
zebrafish
(Danio rerio)
Actinopterygii styx 35
  • 72.82 (n)
  • 77.93 (a)
styx 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2014 35
worm
(Caenorhabditis elegans)
Secernentea Y54F10BM.13 36
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for STYX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STYX Gene

ENSEMBL:
Gene Tree for STYX (if available)
TreeFam:
Gene Tree for STYX (if available)

Paralogs for STYX Gene

(4) SIMAP similar genes for STYX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STYX: view

Variants for STYX Gene

Sequence variations from dbSNP and Humsavar for STYX Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1536175 -- 52,770,111(+) TTCCT(C/T)TAACC intron-variant
rs7142136 -- 52,753,934(+) tctcg(C/T)tctgt intron-variant
rs7143253 -- 52,739,379(+) AGTAC(G/T)CATTT intron-variant
rs8003782 -- 52,735,728(+) AAAAC(G/T)GAATT intron-variant
rs722290 -- 52,750,005(-) ATACT(C/G)AGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STYX Gene

Variant ID Type Subtype PubMed ID
nsv832796 CNV Loss 17160897
nsv470647 CNV Gain 18288195
nsv901952 CNV Loss 21882294
nsv1279 CNV Insertion 18451855

Variation tolerance for STYX Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STYX Gene

HapMap Linkage Disequilibrium report
STYX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STYX Gene

Disorders for STYX Gene

MalaCards: The human disease database

(1) MalaCards diseases for STYX Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
diabetes mellitus, insulin-dependent
  • diabetes, type 1
- elite association - COSMIC cancer census association via MalaCards
Search STYX in MalaCards View complete list of genes associated with diseases

Relevant External Links for STYX

Genetic Association Database (GAD)
STYX
Human Genome Epidemiology (HuGE) Navigator
STYX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STYX
genes like me logo Genes that share disorders with STYX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STYX Gene

Publications for STYX Gene

  1. A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase. (PMID: 7592916) Wishart M.J. … Dixon J.E. (J. Biol. Chem. 1995) 2 3 23 67
  2. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3
  3. Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2. (PMID: 23847209) Reiterer V. … Farhan H. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  4. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PMID: 24035498) Tan M.K. … Harper J.W. (Mol. Cell 2013) 3
  5. Identification of potentially damaging amino acid substitutions leading to human male infertility. (PMID: 19369647) Kuzmin A. … Varmuza S. (Biol. Reprod. 2009) 3

Products for STYX Gene

Sources for STYX Gene

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