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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STYK1 Gene

protein-coding   GIFtS: 61
GCID: GC12M010771

Serine/Threonine/Tyrosine Kinase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine/Threonine/Tyrosine Kinase 11 2 3     SuRTK1062
Novel Oncogene With Kinase Domain2 3     Tyrosine-Protein Kinase STYK12
Protein PK-Unique2 3     EC 2.7.10.23
NOK2 3     

External Ids:    HGNC: 188891   Entrez Gene: 553592   Ensembl: ENSG000000601407   OMIM: 6114335   UniProtKB: Q6J9G03   

Export aliases for STYK1 gene to outside databases

Previous GC identifers: GC12M010664 GC12M010666 GC12M010500


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STYK1 Gene:
Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental
processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 (PubMed
15150103)).(supplied by OMIM, Mar 2008)

GeneCards Summary for STYK1 Gene: 
STYK1 (serine/threonine/tyrosine kinase 1) is a protein-coding gene. Diseases associated with STYK1 include chronic inflammatory demyelinating polyneuritis, and ophthalmia neonatorum, and among its related super-pathways are Focal adhesion. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity and ATP binding. An important paralog of this gene is TIE1.

UniProtKB/Swiss-Prot: STYK1_HUMAN, Q6J9G0
Function: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines.
When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by
activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity)

Gene Wiki entry for STYK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STYK1 gene promoter:
         STAT5B   ER-alpha   Nkx3-1   Nkx3-1 v4   STAT5A   Nkx3-1 v1   Nkx3-1 v2   FAC1   Nkx3-1 v3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTYK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for STYK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STYK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.2

STYK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STYK1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010771:  view genomic region     (about GC identifiers)

Start:
10,771,538 bp from pter      End:
10,826,917 bp from pter
Size:
55,380 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STYK1_HUMAN, Q6J9G0 (See protein sequence)
Recommended Name: Tyrosine-protein kinase STYK1  
Size: 422 amino acids; 47577 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: B2R9T2 Q52LR3 Q9BXY2 Q9NSH1

Explore the universe of human proteins at neXtProt for STYK1: NX_Q6J9G0

Explore proteomics data for STYK1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6J9G0

  • STYK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STYK1 Protein Expression
    REFSEQ proteins: NP_060893.2  
    ENSEMBL proteins: 
     ENSP00000075503   ENSP00000443760   ENSP00000446241   ENSP00000445391   ENSP00000444488  
     ENSP00000444942  

    Human Recombinant Protein Products for STYK1: 
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    Novus Biologicals STYK1 Proteins
    Novus Biologicals STYK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STYK1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0016021integral to membrane IEA--

    STYK1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine/tyrosine kinase 1 
    TK-unique family

    4 InterPro protein domains:
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR008266 Tyr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q6J9G0

    ProtoNet protein and cluster: Q6J9G0

    1 Blocks protein domain: IPB008266 Tyrosine protein kinase

    UniProtKB/Swiss-Prot: STYK1_HUMAN, Q6J9G0
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 1 protein kinase domain


    STYK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STYK1_HUMAN, Q6J9G0
    Function: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines.
    When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by
    activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity)
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Enzyme Number (IUBMB): EC 2.7.10.21

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    STYK1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for STYK1:
     Cell cycle / mitosis defect 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for STYK1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STYK1 
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate STYK1:
    hsa-miR-577 hsa-miR-466 hsa-miR-27a hsa-miR-2116 hsa-miR-32* hsa-miR-27b hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidSTYK1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STYK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STYK1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64


    1 BioSystems Pathway for STYK1
        Focal Adhesion



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STYK1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for STYK1 (Q6J9G02 ENSP000000755034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498412MINT-8392156 MINT-8392173
    AKT1P317492MINT-8392173
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    STYK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STYK1

    2 HMDB Compounds for STYK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about STYK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STYK1 gene: 
    NM_018423.2  

    Unigene Cluster for STYK1:

    Serine/threonine/tyrosine kinase 1
    Hs.24979  [show with all ESTs]
    Unigene Representative Sequence: NM_018423
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000075503(uc001qys.2) ENST00000542924 ENST00000542562 ENST00000538867
    ENST00000535345 ENST00000541561
    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate STYK1:
    hsa-miR-577 hsa-miR-466 hsa-miR-27a hsa-miR-2116 hsa-miR-32* hsa-miR-27b hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidSTYK1 3' UTR sequence
    Inhib. RNA
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    Sirion Biotech Customized lentivirus for stable overexpression of STYK1 
                         Customized lentivirus expression plasmids for stable overexpression of STYK1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STYK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STYK1

    Additional mRNA sequence: 

    AF251059.1 AK313906.1 AL353940.1 AY563054.1 BC093822.1 BC093824.1 

    3 DOTS entries:

    DT.70104689  DT.95363320  DT.91733346 

    24/27 AceView cDNA sequences (see all 27):

    NM_018423 AL353940 AI469618 Z38878 BX093033 AY563054 AF251059 AI590878 
    AV751386 CB243398 BI757514 AI620427 BU663173 BF956525 Z42722 BE151301 
    BF094146 BE151276 BF956523 H29272 BE151275 R49681 BE151286 H08599 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for STYK1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                    -                                                                           
    SP2:                          -                                                                     
    SP3:                    -     -                                                                     


    ECgene alternative splicing isoforms for STYK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STYK1 expression in normal human tissues (normalized intensities)      STYK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACAAATAA
    STYK1 Expression
    About this image


    STYK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Postnatal Endothelial Cells Blood Brain Barrier
             Thalamus
             Trigeminal Ganglion   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             colonic mucosal (ibs)   
     
     Blood Brain Barrier (Nervous System)
             Postnatal Endothelial Cells Blood Brain Barrier
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   
     
     Endothelium (Cardiovascular System)
             Postnatal Endothelial Cells Blood Brain Barrier

    See STYK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STYK1

    SOURCE GeneReport for Unigene cluster: Hs.24979

    UniProtKB/Swiss-Prot: STYK1_HUMAN, Q6J9G0
    Tissue specificity: Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells
    such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous
    leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most
    normal lung tissues, widely expressed in lung cancers

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STYK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for STYK1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Styk11 , 5 serine/threonine/tyrosine kinase 11, 5 81.75(n)1
    78.33(a)1
      6 (63.44 cM)5
    2436591  NM_172891.21  NP_766479.11 
     1312991445 
    chicken
    (Gallus gallus)
    Aves STYK11 serine/threonine/tyrosine kinase 1 61.96(n)
    56.7(a)
      418310  XM_416534.3  XP_416534.3 
    zebrafish
    (Danio rerio)
    Actinopterygii styk11 serine/threonine/tyrosine kinase 1 48.14(n)
    40.86(a)
      324714  XM_003200219.1  XP_003200267.1 
    worm
    (Caenorhabditis elegans)
    Secernentea kin-96
    Y38H6C.206
    (see all 6)
    Protein Y38H6C.20
    (see all 6)
    14(a)
    12(a)
    (see all 6)
    many → 1
    many → 1
    (see all 6)
    X(8432663-8437349)
    V(20547283-20551164)


    ENSEMBL Gene Tree for STYK1 (if available)
    TreeFam Gene Tree for STYK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STYK1 gene
    TIE12  TEK2  
    6 SIMAP similar genes for STYK1 using alignment to 7 protein entries:     STYK1_HUMAN (see all proteins):
    FGFR1    FGFR2    BTK kinase deficient isoform 6    FGR    FGFR4    FES

    STYK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1263 SNPs in STYK1 are shown (see all 1263)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0418444
    A glioblastoma multiforme sample4--see VAR_0418442 V I mis40--------
    rs578513711,2
    C--10556220(+) AGAGC-/CCGCGCG 1 -- us2k10--------
    rs674411251,2
    C,F--10700556(+) CGCGC-/ACA/  
      G
    /GCGC
    ACACA
    2 -- us2k1 cds12NA 4
    rs108451851,2
    C,F,A,H--10771039(+) ATAGGA/GCTTTG 1 -- int126Minor allele frequency- G:0.43NA NS EA CSA WA 2694
    rs1423918921,2
    --10771136(+) TACAGC/TGGCAA 1 -- int10--------
    rs750512811,2
    F--10771137(+) ACAGCG/AGCAAG 1 -- int11Minor allele frequency- A:0.04WA 118
    rs740604601,2
    C,F--10771159(+) CTTTAG/ACTGAC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs771773481,2
    C,F--10771563(+) TGAGCG/ACATAT 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1877612021,2
    --10771587(+) TACAAA/GTACAT 1 -- ut310--------
    rs1910884641,2
    --10771625(+) ACCTTC/GTGAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for STYK1 (10771538 - 10826917 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for STYK1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1480871CNV Deletion17803354
    esv3537CNV Deletion18987735
    esv2671184CNV Deletion23128226
    esv2745540CNV Deletion23290073
    esv2745539CNV Deletion23290073
    esv2745542CNV Deletion23290073
    nsv607CNV Loss18451855
    nsv527604CNV Loss19592680
    nsv832329CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611433    OMIM disorders: --

    9 diseases for STYK1:    About MalaCards
    chronic inflammatory demyelinating polyneuritis    ophthalmia neonatorum    acute leukemia    lung cancer
    endotheliitis    prostate cancer    prostatitis    leukemia
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for STYK1:
    Chronic inflammatory demyelinating polyneuritis

    STYK1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): STYK1
    Human Genome Epidemiology (HuGE) Navigator: STYK1 (3 documents)

    Export disorders for STYK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STYK1 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with STYK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a human putative receptor protein kinase cDNA STYK1. (PubMed id 12841579)1, 2, 3 Ye X.... Mao Y. (2003)
    2. Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers. (PubMed id 17298854)1, 2, 9 Amachika T.... Watanabe N. (2007)
    3. A novel protein tyrosine kinase NOK that shares homology with platelet-derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice. (PubMed id 15150103)1, 2, 9 Liu L....Fu X.-Y. (2004)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. A high-throughput candidate gene mutation screen in l ymphoproliferative and myeloproliferative neoplasias. (PubMed id 19464057)1, 4 Kreil S....Chase A. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Overexpression of serine threonine tyrosine kinase 1/ novel oncogene with kinase domain mRNA in patients with acute leukemia. (PubMed id 19409952)1, 9 Kondoh T....Watanabe N. (2009)
    8. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    9. NOK/STYK1 has a strong tendency towards forming aggreg ates and colocalises with epidermal growth factor receptor in endosomes. (PubMed id 22516751)1 Ding X....Zhang S. (2012)
    10. NOK/STYK1 interacts with GSK-3b and mediates Ser9 phos phorylation through activated Akt. (PubMed id 23010592)1 Li J....Zhang S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55359 HGNC: 18889 AceView: STYK1 Ensembl:ENSG00000060140 euGenes: HUgn55359
    ECgene: STYK1 H-InvDB: STYK1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STYK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STYK1 gene:
    Search GeneIP for patents involving STYK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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