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STYK1 Gene

protein-coding   GIFtS: 60
GCID: GC12M010771

Serine/Threonine/Tyrosine Kinase 1

  See STYK1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Threonine/Tyrosine Kinase 11 2 3     SuRTK1062
Novel Oncogene With Kinase Domain2 3     Tyrosine-Protein Kinase STYK12
Protein PK-Unique2 3     EC 2.7.10.23
NOK2 3     

External Ids:    HGNC: 188891   Entrez Gene: 553592   Ensembl: ENSG000000601407   OMIM: 6114335   UniProtKB: Q6J9G03   

Export aliases for STYK1 gene to outside databases

Previous GC identifers: GC12M010664 GC12M010666 GC12M010500


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STYK1 Gene:
Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental
processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 (PubMed
15150103)).(supplied by OMIM, Mar 2008)

GeneCards Summary for STYK1 Gene:
STYK1 (serine/threonine/tyrosine kinase 1) is a protein-coding gene. Diseases associated with STYK1 include chronic inflammatory demyelinating polyneuritis. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is TIE1.

UniProtKB/Swiss-Prot: STYK1_HUMAN, Q6J9G0
Function: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines.
When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by
activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity)

Gene Wiki entry for STYK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STYK1 gene promoter:
         STAT5B   ER-alpha   Nkx3-1   Nkx3-1 v4   STAT5A   Nkx3-1 v1   Nkx3-1 v2   FAC1   Nkx3-1 v3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTYK1 promoter sequence
   Search Chromatin IP Primers for STYK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STYK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.2

STYK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STYK1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010771:  view genomic region     (about GC identifiers)

Start:
10,771,538 bp from pter      End:
10,826,917 bp from pter
Size:
55,380 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: STYK1_HUMAN, Q6J9G0 (See protein sequence)
Recommended Name: Tyrosine-protein kinase STYK1  
Size: 422 amino acids; 47577 Da
Secondary accessions: B2R9T2 Q52LR3 Q9BXY2 Q9NSH1

Explore the universe of human proteins at neXtProt for STYK1: NX_Q6J9G0

Explore proteomics data for STYK1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STYK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060893.2  
    ENSEMBL proteins: 
     ENSP00000075503   ENSP00000443760   ENSP00000446241   ENSP00000445391   ENSP00000444488  
     ENSP00000444942  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine/tyrosine kinase 1
    TK-unique family

    4 InterPro protein domains:
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR008266 Tyr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q6J9G0

    ProtoNet protein and cluster: Q6J9G0

    1 Blocks protein domain: IPB008266 Tyrosine protein kinase

    UniProtKB/Swiss-Prot: STYK1_HUMAN, Q6J9G0
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with STYK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STYK1_HUMAN, Q6J9G0
    Function: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines.
    When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by
    activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity)
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Enzyme Number (IUBMB): EC 2.7.10.21

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with STYK1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STYK1:
     Cell cycle / mitosis defect 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for STYK1

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    7 qRT-PCR Assays for microRNAs that regulate STYK1:
    hsa-miR-577 hsa-miR-466 hsa-miR-27a hsa-miR-2116 hsa-miR-32* hsa-miR-27b hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidSTYK1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STYK1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STYK1_HUMAN, Q6J9G0: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol2
    mitochondrion2
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with STYK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STYK1 About    
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal Adhesion0.65


    1 BioSystems Pathway for STYK1
        Focal Adhesion



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STYK1
    Interactions:

        Search GeneGlobe Interaction Network for STYK1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for STYK1 (Q6J9G01, 2 ENSP000000755034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498411, 2EBI-6424915,EBI-373586 MINT-8392156 MINT-8392173
    AKT1P317492MINT-8392173
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with STYK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for STYK1

    2 HMDB Compounds for STYK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STYK1 gene: 
    NM_018423.2  

    Unigene Cluster for STYK1:

    Serine/threonine/tyrosine kinase 1
    Hs.24979  [show with all ESTs]
    Unigene Representative Sequence: NM_018423
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000075503(uc001qys.2) ENST00000542924 ENST00000542562 ENST00000538867
    ENST00000535345 ENST00000541561
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate STYK1:
    hsa-miR-577 hsa-miR-466 hsa-miR-27a hsa-miR-2116 hsa-miR-32* hsa-miR-27b hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidSTYK1 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat STYK1
      QuantiFast Probe-based Assays in human, mouse, rat STYK1

    Additional mRNA sequence: 

    AF251059.1 AK313906.1 AL353940.1 AY563054.1 BC093822.1 BC093824.1 

    3 DOTS entries:

    DT.70104689  DT.95363320  DT.91733346 

    Selected AceView cDNA sequences (see all 27):

    AI469618 Z38878 BX093033 AL353940 NM_018423 AV751386 BI757514 CB243398 
    AY563054 AF251059 AI590878 BU663173 AI620427 BF956525 BE151301 Z42722 
    H29272 BF956523 BE151275 BF094146 BE151276 BE151286 R49681 BE151269 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for STYK1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                    -                                                                           
    SP2:                          -                                                                     
    SP3:                    -     -                                                                     


    ECgene alternative splicing isoforms for STYK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STYK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACAAATAA
    STYK1 Expression
    About this image


    STYK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Mature Endothelial Cells Blood Brain Barrier
             Thalamus
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
    STYK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STYK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.24979

    UniProtKB/Swiss-Prot: STYK1_HUMAN, Q6J9G0
    Tissue specificity: Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells
    such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous
    leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most
    normal lung tissues, widely expressed in lung cancers

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STYK1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Styk11 , 5 serine/threonine/tyrosine kinase 11, 5 81.75(n)1
    78.33(a)1
      6 (63.44 cM)5
    2436591  NM_172891.21  NP_766479.11 
     1312991445 
    chicken
    (Gallus gallus)
    Aves STYK11 serine/threonine/tyrosine kinase 1 61.89(n)
    56.56(a)
      418310  XM_004938145.1  XP_004938202.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia styk11 serine/threonine/tyrosine kinase 1 56.82(n)
    52.11(a)
      100170540  NM_001130318.1  NP_001123790.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018861091 tyrosine-protein kinase STYK1-like 53.21(n)
    46.18(a)
      101886109  XM_005159488.1  XP_005159545.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32776
    tor6
    torso
    13(a)
    12(a)
    many → 1
    many → 1
    2L(3304100-3317418)
    2R(3590680-3597042)
    worm
    (Caenorhabditis elegans)
    Secernentea R151.46
    Protein R151.4, isoform a
    29(a)
    1 ↔ 1
    III(7219974-7221186) WBGene00020108


    ENSEMBL Gene Tree for STYK1 (if available)
    TreeFam Gene Tree for STYK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STYK1 gene
    TIE12  TEK2  
    5 SIMAP similar genes for STYK1 using alignment to 7 protein entries:     STYK1_HUMAN (see all proteins):
    FGFR1    FGFR2    BTK kinase deficient isoform 6    FGR    FES

    Find genes that share paralogs with STYK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STYK1 (see all 1263)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0418444
    A glioblastoma multiforme sample4--see VAR_0418442 V I mis40--------
    rs578513711,2
    C--10556220(+) AGAGC-/CCGCGCG 1 -- us2k10--------
    rs674411251,2
    C,F--10700556(+) CGCGC-/ACA/  
      G
    /GCGC
    ACACA
    2 -- us2k1 cds12NA 4
    rs108451851,2
    C,F,A,H--10771039(+) ATAGGA/GCTTTG 1 -- int126Minor allele frequency- G:0.43NA NS EA CSA WA 2694
    rs1423918921,2
    --10771136(+) TACAGC/TGGCAA 1 -- int10--------
    rs750512811,2
    F--10771137(+) ACAGCG/AGCAAG 1 -- int11Minor allele frequency- A:0.04WA 118
    rs740604601,2
    C,F--10771159(+) CTTTAG/ACTGAC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs771773481,2
    C,F--10771563(+) TGAGCG/ACATAT 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1877612021,2
    --10771587(+) TACAAA/GTACAT 1 -- ut310--------
    rs1910884641,2
    --10771625(+) ACCTTC/GTGAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for STYK1 (10771538 - 10826917 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for STYK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1480871CNV Deletion17803354
    esv3537CNV Deletion18987735
    esv2671184CNV Deletion23128226
    esv2745540CNV Deletion23290073
    esv2745539CNV Deletion23290073
    esv2745542CNV Deletion23290073
    nsv607CNV Loss18451855
    nsv527604CNV Loss19592680
    nsv832329CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STYK1
    DNA2.0 Custom Variant and Variant Library Synthesis for STYK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611433    OMIM disorders: --

    1 disease for STYK1:    
    About MalaCards
    chronic inflammatory demyelinating polyneuritis

    1 disease from the University of Copenhagen DISEASES database for STYK1:
    Chronic inflammatory demyelinating polyneuritis

    Find genes that share disorders with STYK1           About GenesLikeMe

    Genetic Association Database (GAD): STYK1
    Human Genome Epidemiology (HuGE) Navigator: STYK1 (3 documents)

    Export disorders for STYK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STYK1 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with STYK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a human putative receptor protein kinase cDNA STYK1. (PubMed id 12841579)1, 2, 3 Ye X.... Mao Y. (Mol. Biol. Rep. 2003)
    2. Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers. (PubMed id 17298854)1, 2, 9 Amachika T.... Watanabe N. (Lung Cancer 2007)
    3. A novel protein tyrosine kinase NOK that shares homology with platelet-derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice. (PubMed id 15150103)1, 2, 9 Liu L....Fu X.-Y. (Cancer Res. 2004)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias. (PubMed id 19464057)1, 4 Kreil S....Chase A. (Leuk. Res. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Overexpression of serine threonine tyrosine kinase 1/novel oncogene with kinase domain mRNA in patients with acute leukemia. (PubMed id 19409952)1, 9 Kondoh T....Watanabe N. (Exp. Hematol. 2009)
    8. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    9. NOK/STYK1 has a strong tendency towards forming aggregates and colocalises with epidermal growth factor receptor in endosomes. (PubMed id 22516751)1 Ding X....Zhang S. (Biochem. Biophys. Res. Commun. 2012)
    10. NOK/STYK1 interacts with GSK-3I^ and mediates Ser9 phosphorylation through activated Akt. (PubMed id 23010592)1 Li J....Zhang S. (FEBS Lett. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55359 HGNC: 18889 AceView: STYK1 Ensembl:ENSG00000060140 euGenes: HUgn55359
    ECgene: STYK1 H-InvDB: STYK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STYK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STYK1 gene:
    Search GeneIP for patents involving STYK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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