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Aliases for STYK1 Gene

Aliases for STYK1 Gene

  • Serine/Threonine/Tyrosine Kinase 1 2 3 4
  • Novel Oncogene With Kinase Domain 3 4
  • Protein PK-Unique 3 4
  • NOK 3 4
  • Tyrosine-Protein Kinase STYK1 3
  • EC 2.7.10.2 4
  • SuRTK106 3

External Ids for STYK1 Gene

Summaries for STYK1 Gene

Entrez Gene Summary for STYK1 Gene

  • Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]

GeneCards Summary for STYK1 Gene

STYK1 (Serine/Threonine/Tyrosine Kinase 1) is a Protein Coding gene. Diseases associated with STYK1 include chronic inflammatory demyelinating polyneuritis. Among its related pathways are Focal adhesion. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is TEK.

UniProtKB/Swiss-Prot for STYK1 Gene

  • Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3-kinases (PI3K) pathways (By similarity).

Gene Wiki entry for STYK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STYK1 Gene

Genomics for STYK1 Gene

Genomic Location for STYK1 Gene

Start:
10,618,923 bp from pter
End:
10,674,318 bp from pter
Size:
55,396 bases
Orientation:
Minus strand

Genomic View for STYK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STYK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STYK1 Gene

Regulatory Elements for STYK1 Gene

Proteins for STYK1 Gene

  • Protein details for STYK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6J9G0-STYK1_HUMAN
    Recommended name:
    Tyrosine-protein kinase STYK1
    Protein Accession:
    Q6J9G0
    Secondary Accessions:
    • B2R9T2
    • Q52LR3
    • Q9BXY2
    • Q9NSH1

    Protein attributes for STYK1 Gene

    Size:
    422 amino acids
    Molecular mass:
    47577 Da
    Quaternary structure:
    No Data Available

neXtProt entry for STYK1 Gene

Proteomics data for STYK1 Gene at MOPED

Post-translational modifications for STYK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STYK1 Gene

No data available for DME Specific Peptides for STYK1 Gene

Domains for STYK1 Gene

Gene Families for STYK1 Gene

UniProtKB/Swiss-Prot:

STYK1_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q6J9G0
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.:
    • Q6J9G0
genes like me logo Genes that share domains with STYK1: view

Function for STYK1 Gene

Molecular function for STYK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3-kinases (PI3K) pathways (By similarity).

Enzyme Numbers (IUBMB) for STYK1 Gene

Gene Ontology (GO) - Molecular Function for STYK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA --
GO:0005102 NOT receptor binding IBA --
GO:0005515 protein binding IPI 23010592
genes like me logo Genes that share ontologies with STYK1: view

Phenotypes for STYK1 Gene

GenomeRNAi human phenotypes for STYK1:
genes like me logo Genes that share phenotypes with STYK1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for STYK1 Gene

Localization for STYK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STYK1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STYK1 Gene COMPARTMENTS Subcellular localization image for STYK1 gene
Compartment Confidence
plasma membrane 4
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for STYK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0016021 integral component of membrane IEA --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with STYK1: view

Pathways for STYK1 Gene

SuperPathways for STYK1 Gene

Superpath Contained pathways
1 Focal adhesion
genes like me logo Genes that share pathways with STYK1: view

Pathways by source for STYK1 Gene

1 BioSystems pathway for STYK1 Gene

Gene Ontology (GO) - Biological Process for STYK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0018108 peptidyl-tyrosine phosphorylation --
GO:0030154 cell differentiation IBA --
GO:0038083 peptidyl-tyrosine autophosphorylation IBA --
genes like me logo Genes that share ontologies with STYK1: view

Compounds for STYK1 Gene

(2) HMDB Compounds for STYK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with STYK1: view

Transcripts for STYK1 Gene

Unigene Clusters for STYK1 Gene

Serine/threonine/tyrosine kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STYK1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: -
SP3: - -

Relevant External Links for STYK1 Gene

GeneLoc Exon Structure for
STYK1
ECgene alternative splicing isoforms for
STYK1

Expression for STYK1 Gene

mRNA expression in normal human tissues for STYK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STYK1 Gene

This gene is overexpressed in Colon - Transverse (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for STYK1 Gene

SOURCE GeneReport for Unigene cluster for STYK1 Gene Hs.24979

mRNA Expression by UniProt/SwissProt for STYK1 Gene

Q6J9G0-STYK1_HUMAN
Tissue specificity: Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers.
genes like me logo Genes that share expressions with STYK1: view

Orthologs for STYK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for STYK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STYK1 36
  • 96.34 (n)
  • 95.7 (a)
STYK1 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STYK1 36
  • 82.93 (n)
  • 76.79 (a)
STYK1 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STYK1 36
  • 86.21 (n)
  • 82.44 (a)
STYK1 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Styk1 36
  • 81.75 (n)
  • 78.33 (a)
Styk1 16
Styk1 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STYK1 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 4 (a)
ManyToMany
-- 37
  • 18 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Styk1 36
  • 81.43 (n)
  • 78.81 (a)
chicken
(Gallus gallus)
Aves STYK1 36
  • 61.89 (n)
  • 56.56 (a)
STYK1 37
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia styk1 36
  • 56.82 (n)
  • 52.11 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101886109 36
  • 53.21 (n)
  • 46.18 (a)
styk1 37
  • 33 (a)
OneToMany
STYK1 (2 of 3) 37
  • 34 (a)
OneToMany
STYK1 (3 of 3) 37
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3277 37
  • 13 (a)
OneToMany
tor 37
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R151.4 37
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToMany
-- 37
  • 32 (a)
OneToMany
-- 37
  • 33 (a)
OneToMany
Species with no ortholog for STYK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STYK1 Gene

ENSEMBL:
Gene Tree for STYK1 (if available)
TreeFam:
Gene Tree for STYK1 (if available)

Paralogs for STYK1 Gene

Paralogs for STYK1 Gene

Selected SIMAP similar genes for STYK1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with STYK1: view

Variants for STYK1 Gene

Sequence variations from dbSNP and Humsavar for STYK1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs755498 -- 10,621,721(+) ATGAG(A/G)TAGGT intron-variant
rs897879 -- 10,622,227(-) CTTAC(C/T)TTGTC intron-variant
rs897880 -- 10,622,218(-) TCTTA(G/T)TTGAT intron-variant
rs897881 -- 10,621,170(-) GTATA(A/C)GGAGG intron-variant
rs897882 -- 10,621,016(-) TATAT(A/G)TGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STYK1 Gene

Variant ID Type Subtype PubMed ID
nsv832329 CNV Gain 17160897
nsv607 CNV Loss 18451855
esv2745539 CNV Deletion 23290073
esv2745540 CNV Deletion 23290073
esv3537 CNV Deletion 18987735
esv2745542 CNV Deletion 23290073
esv2671184 CNV Deletion 23128226
esv1480871 CNV Deletion 17803354
nsv527604 CNV Loss 19592680

Relevant External Links for STYK1 Gene

HapMap Linkage Disequilibrium report
STYK1

Disorders for STYK1 Gene

(1) University of Copenhagen DISEASES for STYK1 Gene

Relevant External Links for STYK1

Genetic Association Database (GAD)
STYK1
Human Genome Epidemiology (HuGE) Navigator
STYK1
genes like me logo Genes that share disorders with STYK1: view

No data available for UniProtKB/Swiss-Prot for STYK1 Gene

Publications for STYK1 Gene

  1. A novel protein tyrosine kinase NOK that shares homology with platelet-derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice. (PMID: 15150103) Liu L. … Fu X.-Y. (Cancer Res. 2004) 3 4 23
  2. Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers. (PMID: 17298854) Amachika T. … Watanabe N. (Lung Cancer 2007) 3 4 23
  3. Isolation and characterization of a human putative receptor protein kinase cDNA STYK1. (PMID: 12841579) Ye X. … Mao Y. (Mol. Biol. Rep. 2003) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias. (PMID: 19464057) Kreil S. … Chase A. (Leuk. Res. 2009) 3 49

Products for STYK1 Gene

  • Addgene plasmids for STYK1

Sources for STYK1 Gene

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