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Aliases for STXBP6 Gene

Aliases for STXBP6 Gene

  • Syntaxin Binding Protein 6 2 3
  • Syntaxin Binding Protein 6 (Amisyn) 3 5
  • Amisyn 3 4
  • HSPC156 3

External Ids for STXBP6 Gene

Previous GeneCards Identifiers for STXBP6 Gene

  • GC14M019066
  • GC14M023268
  • GC14M023271
  • GC14M024348
  • GC14M025278
  • GC14M005395

Summaries for STXBP6 Gene

Entrez Gene Summary for STXBP6 Gene

  • STXBP6 binds components of the SNARE complex (see MIM 603215) and may be involved in regulating SNARE complex formation (Scales et al., 2002 [PubMed 12145319]).[supplied by OMIM, Mar 2008]

GeneCards Summary for STXBP6 Gene

STXBP6 (Syntaxin Binding Protein 6) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding and GTP-Rho binding. An important paralog of this gene is EXOC1.

UniProtKB/Swiss-Prot for STXBP6 Gene

  • Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STXBP6 Gene

Genomics for STXBP6 Gene

Regulatory Elements for STXBP6 Gene

Enhancers for STXBP6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STXBP6 on UCSC Golden Path with GeneCards custom track

Promoters for STXBP6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STXBP6 on UCSC Golden Path with GeneCards custom track

Genomic Location for STXBP6 Gene

24,809,654 bp from pter
25,050,297 bp from pter
240,644 bases
Minus strand

Genomic View for STXBP6 Gene

Genes around STXBP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STXBP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STXBP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STXBP6 Gene

Proteins for STXBP6 Gene

  • Protein details for STXBP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Syntaxin-binding protein 6
    Protein Accession:
    Secondary Accessions:
    • D3DS78
    • Q8N3H1
    • Q8N8D5
    • Q96GF3
    • Q9P008

    Protein attributes for STXBP6 Gene

    210 amino acids
    Molecular mass:
    23554 Da
    Quaternary structure:
    • Part of a ternary complex containing SNAP25 and STX1A that can be dissociated by NAPA and NSF. Interacts with STX4A.
    • Sequence=AAM46624.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STXBP6 Gene


neXtProt entry for STXBP6 Gene

Proteomics data for STXBP6 Gene at MOPED

Post-translational modifications for STXBP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for STXBP6 Gene

Domains & Families for STXBP6 Gene

Protein Domains for STXBP6 Gene


Suggested Antigen Peptide Sequences for STXBP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 v-SNARE coiled-coil homology domain.
  • Contains 1 v-SNARE coiled-coil homology domain.
genes like me logo Genes that share domains with STXBP6: view

No data available for Gene Families for STXBP6 Gene

Function for STXBP6 Gene

Molecular function for STXBP6 Gene

UniProtKB/Swiss-Prot Function:
Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.

Gene Ontology (GO) - Molecular Function for STXBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IBA --
genes like me logo Genes that share ontologies with STXBP6: view
genes like me logo Genes that share phenotypes with STXBP6: view

Animal Model Products

miRNA for STXBP6 Gene

miRTarBase miRNAs that target STXBP6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STXBP6 Gene

Localization for STXBP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STXBP6 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for STXBP6 Gene COMPARTMENTS Subcellular localization image for STXBP6 gene
Compartment Confidence
cytosol 3
plasma membrane 3
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for STXBP6 Gene

Pathways & Interactions for STXBP6 Gene

SuperPathways for STXBP6 Gene

No Data Available

Interacting Proteins for STXBP6 Gene

Gene Ontology (GO) - Biological Process for STXBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IBA --
GO:0035542 regulation of SNARE complex assembly IDA 12145319
genes like me logo Genes that share ontologies with STXBP6: view

No data available for Pathways by source and SIGNOR curated interactions for STXBP6 Gene

Drugs & Compounds for STXBP6 Gene

No Compound Related Data Available

Transcripts for STXBP6 Gene

Unigene Clusters for STXBP6 Gene

Syntaxin binding protein 6 (amisyn):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STXBP6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - - -
SP3: - - - -
SP4: - - - -

Relevant External Links for STXBP6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STXBP6 Gene

mRNA expression in normal human tissues for STXBP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STXBP6 Gene

This gene is overexpressed in Spinal cord (18.1), Frontal cortex (15.3), and Fetal Brain (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STXBP6 Gene

SOURCE GeneReport for Unigene cluster for STXBP6 Gene Hs.508958

mRNA Expression by UniProt/SwissProt for STXBP6 Gene

Tissue specificity: Detected at low levels in brain, and at very low levels in heart, adrenal gland, testis, liver and kidney.
genes like me logo Genes that share expression patterns with STXBP6: view

Protein tissue co-expression partners for STXBP6 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for STXBP6 Gene

Orthologs for STXBP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for STXBP6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STXBP6 35
  • 92.86 (n)
  • 99.05 (a)
  • 100 (a)
(Canis familiaris)
Mammalia STXBP6 35
  • 93.17 (n)
  • 99.05 (a)
  • 99 (a)
(Mus musculus)
Mammalia Stxbp6 35
  • 92.86 (n)
  • 98.57 (a)
Stxbp6 16
Stxbp6 36
  • 99 (a)
(Pan troglodytes)
Mammalia STXBP6 35
  • 99.68 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Stxbp6 35
  • 93.49 (n)
  • 99.05 (a)
(Monodelphis domestica)
Mammalia STXBP6 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia STXBP6 36
  • 95 (a)
(Gallus gallus)
Aves STXBP6 35
  • 85.08 (n)
  • 94.29 (a)
  • 94 (a)
(Anolis carolinensis)
Reptilia STXBP6 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2147 35
stxbp6 35
  • 74.76 (n)
  • 81.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68796 35
(Danio rerio)
Actinopterygii stxbp6 35
  • 70.79 (n)
  • 74.76 (a)
STXBP6 (2 of 2) 36
  • 66 (a)
stxbp6l 36
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec3 36
  • 5 (a)
(Caenorhabditis elegans)
Secernentea sec-3 36
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for STXBP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STXBP6 Gene

Gene Tree for STXBP6 (if available)
Gene Tree for STXBP6 (if available)

Paralogs for STXBP6 Gene

Paralogs for STXBP6 Gene

(1) SIMAP similar genes for STXBP6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STXBP6: view

Variants for STXBP6 Gene

Sequence variations from dbSNP and Humsavar for STXBP6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs9319 -- 24,812,492(-) GCATC(A/G)GCTTC utr-variant-3-prime
rs12988 -- 24,812,589(+) AAAAA(C/T)CACTC utr-variant-3-prime
rs16757 -- 24,890,676(+) TCCTT(C/T)TGGAC intron-variant
rs17112 -- 24,890,773(-) TGAAT(C/T)TCCTG intron-variant
rs1272975 -- 24,866,948(-) gtttt(C/T)gctct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STXBP6 Gene

Variant ID Type Subtype PubMed ID
nsv901504 CNV Gain 21882294
nsv901505 CNV Gain 21882294
nsv525203 CNV Gain 19592680
nsv456169 CNV Gain 19166990
nsv901506 CNV Gain 21882294
nsv901507 CNV Gain 21882294
esv21738 CNV Loss 19812545
nsv901508 CNV Gain 21882294
nsv901509 CNV Gain 21882294
nsv901510 CNV Gain 21882294
esv25325 CNV Loss 19812545
nsv901511 CNV Gain 21882294
nsv527684 CNV Loss 19592680

Variation tolerance for STXBP6 Gene

Residual Variation Intolerance Score: 26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STXBP6 Gene

Disorders for STXBP6 Gene

Relevant External Links for STXBP6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STXBP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STXBP6 Gene

Publications for STXBP6 Gene

  1. Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly. (PMID: 12145319) Scales S.J. … Scheller R.H. (J. Biol. Chem. 2002) 2 3 4 67
  2. Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults. (PMID: 25133637) Scannell Bryan M. … Ahsan H. (PLoS ONE 2014) 3
  3. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  4. CD6 and syntaxin binding protein 6 variants and response to tumor necrosis factor alpha inhibitors in Danish patients with rheumatoid arthritis. (PMID: 22685579) Krintel S.B. … Hetland M.L. (PLoS ONE 2012) 3
  5. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3

Products for STXBP6 Gene

Sources for STXBP6 Gene