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Aliases for STXBP6 Gene

Aliases for STXBP6 Gene

  • Syntaxin Binding Protein 6 (Amisyn) 2 3
  • Amisyn 3 4 6
  • HSPC156 3 6
  • Syntaxin-Binding Protein 6 3

External Ids for STXBP6 Gene

Previous GeneCards Identifiers for STXBP6 Gene

  • GC14M019066
  • GC14M023268
  • GC14M023271
  • GC14M024348
  • GC14M025278
  • GC14M005395

Summaries for STXBP6 Gene

Entrez Gene Summary for STXBP6 Gene

  • STXBP6 binds components of the SNARE complex (see MIM 603215) and may be involved in regulating SNARE complex formation (Scales et al., 2002 [PubMed 12145319]).[supplied by OMIM, Mar 2008]

GeneCards Summary for STXBP6 Gene

STXBP6 (Syntaxin Binding Protein 6 (Amisyn)) is a Protein Coding gene. An important paralog of this gene is EXOC1.

UniProtKB/Swiss-Prot for STXBP6 Gene

  • Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STXBP6 Gene

Genomics for STXBP6 Gene

Regulatory Elements for STXBP6 Gene

Genomic Location for STXBP6 Gene

Start:
24,809,654 bp from pter
End:
25,050,297 bp from pter
Size:
240,644 bases
Orientation:
Minus strand

Genomic View for STXBP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STXBP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STXBP6 Gene

Proteins for STXBP6 Gene

  • Protein details for STXBP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFX7-STXB6_HUMAN
    Recommended name:
    Syntaxin-binding protein 6
    Protein Accession:
    Q8NFX7
    Secondary Accessions:
    • D3DS78
    • Q8N3H1
    • Q8N8D5
    • Q96GF3
    • Q9P008

    Protein attributes for STXBP6 Gene

    Size:
    210 amino acids
    Molecular mass:
    23554 Da
    Quaternary structure:
    • Part of a ternary complex containing SNAP25 and STX1A that can be dissociated by NAPA and NSF. Interacts with STX4A.
    SequenceCaution:
    • Sequence=AAM46624.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STXBP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STXBP6 Gene

Proteomics data for STXBP6 Gene at MOPED

Post-translational modifications for STXBP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STXBP6 Gene

Domains for STXBP6 Gene

Protein Domains for STXBP6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STXBP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NFX7

UniProtKB/Swiss-Prot:

STXB6_HUMAN :
  • Q8NFX7
Domain:
  • Contains 1 v-SNARE coiled-coil homology domain.
genes like me logo Genes that share domains with STXBP6: view

No data available for Gene Families for STXBP6 Gene

Function for STXBP6 Gene

Molecular function for STXBP6 Gene

UniProtKB/Swiss-Prot Function: Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis

Gene Ontology (GO) - Molecular Function for STXBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IBA --
GO:0017049 GTP-Rho binding IBA --
genes like me logo Genes that share ontologies with STXBP6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for STXBP6 Gene

Localization for STXBP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STXBP6 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STXBP6 Gene COMPARTMENTS Subcellular localization image for STXBP6 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for STXBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IBA --
GO:0005737 cytoplasm --
GO:0005886 plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STXBP6: view

Pathways for STXBP6 Gene

SuperPathways for STXBP6 Gene

No Data Available

Interacting Proteins for STXBP6 Gene

Gene Ontology (GO) - Biological Process for STXBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006893 Golgi to plasma membrane transport IBA --
GO:0016192 vesicle-mediated transport --
GO:0035542 regulation of SNARE complex assembly IDA 12145319
GO:0045920 negative regulation of exocytosis TAS 15217342
GO:0051601 exocyst localization IBA --
genes like me logo Genes that share ontologies with STXBP6: view

No data available for Pathways by source for STXBP6 Gene

Transcripts for STXBP6 Gene

Unigene Clusters for STXBP6 Gene

Syntaxin binding protein 6 (amisyn):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STXBP6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - - -
SP2:
SP3: - - - -
SP4: - - - -

Relevant External Links for STXBP6 Gene

GeneLoc Exon Structure for
STXBP6
ECgene alternative splicing isoforms for
STXBP6

Expression for STXBP6 Gene

mRNA expression in normal human tissues for STXBP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STXBP6 Gene

SOURCE GeneReport for Unigene cluster for STXBP6 Gene Hs.508958

mRNA Expression by UniProt/SwissProt for STXBP6 Gene

Q8NFX7-STXB6_HUMAN
Tissue specificity: Detected at low levels in brain, and at very low levels in heart, adrenal gland, testis, liver and kidney.
genes like me logo Genes that share expressions with STXBP6: view

No data available for mRNA differential expression in normal tissues for STXBP6 Gene

Orthologs for STXBP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for STXBP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STXBP6 35
  • 99.68 (n)
  • 100 (a)
STXBP6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STXBP6 35
  • 92.86 (n)
  • 99.05 (a)
STXBP6 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STXBP6 35
  • 93.17 (n)
  • 99.05 (a)
STXBP6 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stxbp6 35
  • 92.86 (n)
  • 98.57 (a)
Stxbp6 16
Stxbp6 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STXBP6 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STXBP6 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stxbp6 35
  • 93.49 (n)
  • 99.05 (a)
chicken
(Gallus gallus)
Aves STXBP6 35
  • 85.08 (n)
  • 94.29 (a)
STXBP6 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STXBP6 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68796 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2147 35
stxbp6 35
  • 74.76 (n)
  • 81.9 (a)
zebrafish
(Danio rerio)
Actinopterygii stxbp6 35
  • 70.79 (n)
  • 74.76 (a)
STXBP6 (2 of 2) 36
  • 66 (a)
OneToMany
stxbp6l 36
  • 36 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sec3 36
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-3 36
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToOne
Species with no ortholog for STXBP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STXBP6 Gene

ENSEMBL:
Gene Tree for STXBP6 (if available)
TreeFam:
Gene Tree for STXBP6 (if available)

Paralogs for STXBP6 Gene

Paralogs for STXBP6 Gene

Selected SIMAP similar genes for STXBP6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STXBP6: view

Variants for STXBP6 Gene

Sequence variations from dbSNP and Humsavar for STXBP6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs9319 -- 24,812,492(-) GCATC(A/G)GCTTC utr-variant-3-prime
rs12988 -- 24,812,589(+) AAAAA(C/T)CACTC utr-variant-3-prime
rs16757 -- 24,890,676(+) TCCTT(C/T)TGGAC intron-variant
rs17112 -- 24,890,773(-) TGAAT(C/T)TCCTG intron-variant
rs189985 -- 24,875,001(-) GATTG(C/T)TTAGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for STXBP6 Gene

Variant ID Type Subtype PubMed ID
nsv901504 CNV Gain 21882294
nsv901505 CNV Gain 21882294
nsv525203 CNV Gain 19592680
nsv456169 CNV Gain 19166990
nsv901506 CNV Gain 21882294
nsv901507 CNV Gain 21882294
esv21738 CNV Loss 19812545
nsv901508 CNV Gain 21882294
nsv901509 CNV Gain 21882294
nsv901510 CNV Gain 21882294
esv25325 CNV Loss 19812545
nsv901511 CNV Gain 21882294
nsv527684 CNV Loss 19592680

Relevant External Links for STXBP6 Gene

HapMap Linkage Disequilibrium report
STXBP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STXBP6 Gene

Disorders for STXBP6 Gene

Relevant External Links for STXBP6

Genetic Association Database (GAD)
STXBP6
Human Genome Epidemiology (HuGE) Navigator
STXBP6
genes like me logo Genes that share disorders with STXBP6: view

No data available for UniProtKB/Swiss-Prot for STXBP6 Gene

Publications for STXBP6 Gene

  1. Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly. (PMID: 12145319) Scales S.J. … Scheller R.H. (J. Biol. Chem. 2002) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PMID: 21738478) Okada Y. … Kamatani N. (PLoS Genet. 2011) 3 48

Products for STXBP6 Gene

Sources for STXBP6 Gene

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