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STXBP6 Gene

protein-coding   GIFtS: 51
GCID: GC14M025278

Syntaxin Binding Protein 6 (Amisyn)

  Search for STXBP6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Syntaxin Binding Protein 6 (Amisyn)1 2
amisyn2
Syntaxin-Binding Protein 62
Amisyn3
AMISYN5
HSPC1565

External Ids:    HGNC: 196661   Entrez Gene: 290912   Ensembl: ENSG000001689527   OMIM: 6079585   UniProtKB: Q8NFX73   

Export aliases for STXBP6 gene to outside databases

Previous GC identifers: GC14M019066 GC14M023268 GC14M023271 GC14M024348 GC14M005395


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STXBP6 Gene:
STXBP6 binds components of the SNARE complex (see MIM 603215) and may be involved in regulating SNARE complex
formation (Scales et al., 2002 (PubMed 12145319)).(supplied by OMIM, Mar 2008)

GeneCards Summary for STXBP6 Gene:
STXBP6 (syntaxin binding protein 6 (amisyn)) is a protein-coding gene. An important paralog of this gene is EXOC1.

UniProtKB/Swiss-Prot: STXB6_HUMAN, Q8NFX7
Function: Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional
SNARE complexes and exocytosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STXBP6 gene promoter:
         ER-alpha   NF-E2 p45   Ik-3   Meis-1b   Pax-3   SRY   Meis-1a   ZIC2/Zic2   NF-E2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTXBP6 promoter sequence
   Search Chromatin IP Primers for STXBP6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STXBP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q12   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11.2

STXBP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STXBP6 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M025278:  view genomic region     (about GC identifiers)

Start:
25,278,862 bp from pter      End:
25,519,503 bp from pter
Size:
240,642 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STXB6_HUMAN, Q8NFX7 (See protein sequence)
Recommended Name: Syntaxin-binding protein 6  
Size: 210 amino acids; 23554 Da
Subunit: Part of a ternary complex containing SNAP25 and STX1A that can be dissociated by NAPA and NSF. Interacts
with STX4A
Sequence caution: Sequence=AAM46624.1; Type=Erroneous initiation;
Secondary accessions: D3DS78 Q8N3H1 Q8N8D5 Q96GF3 Q9P008
Alternative splicing: 3 isoforms:  Q8NFX7-1   Q8NFX7-2   Q8NFX7-3   (May be due to an intron retention)

Explore the universe of human proteins at neXtProt for STXBP6: NX_Q8NFX7

Explore proteomics data for STXBP6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STXBP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054897.4  
    ENSEMBL proteins: 
     ENSP00000379928   ENSP00000447383   ENSP00000324302   ENSP00000397212   ENSP00000449536  
     ENSP00000449379   ENSP00000447655   ENSP00000447268   ENSP00000351083  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001388 Synaptobrevin
     IPR028258 Sec3-PIP2_bind

    Graphical View of Domain Structure for InterPro Entry Q8NFX7

    ProtoNet protein and cluster: Q8NFX7

    1 Blocks protein domain: IPB001388 Synaptobrevin

    UniProtKB/Swiss-Prot: STXB6_HUMAN, Q8NFX7
    Similarity: Contains 1 v-SNARE coiled-coil homology domain


    Find genes that share domains with STXBP6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STXB6_HUMAN, Q8NFX7
    Function: Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional
    SNARE complexes and exocytosis

    Animal Models:

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    hsa-miR-34b* hsa-miR-548am hsa-miR-133b hsa-miR-578 hsa-miR-133a hsa-miR-548x hsa-miR-889 hsa-miR-449c
    SwitchGear 3'UTR luciferase reporter plasmidSTXBP6 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STXB6_HUMAN, Q8NFX7: Cytoplasm. Membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with STXBP6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STXBP6
    Interactions:

        GeneGlobe Interaction Network for STXBP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for STXBP6 (Q8NFX73 ENSP000003243024) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX4Q128463, ENSP000003177144I2D: score=1 STRING: ENSP00000317714
    SNAP25P608803, ENSP000002549764I2D: score=1 STRING: ENSP00000254976
    STX1AQ166233, ENSP000002228124I2D: score=1 STRING: ENSP00000222812
    EXOC2ENSP000002304494STRING: ENSP00000230449
    EXOC4ENSP000002538614STRING: ENSP00000253861
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016192vesicle-mediated transport IEA--

    Find genes that share ontologies with STXBP6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STXBP6 (STXB6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STXBP6 gene: 
    NM_014178.6  

    Unigene Cluster for STXBP6:

    Syntaxin binding protein 6 (amisyn)
    Hs.508958  [show with all ESTs]
    Unigene Representative Sequence: AL834346
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396700 ENST00000548724(uc001wpv.3) ENST00000323944(uc001wpw.3)
    ENST00000419632(uc001wpt.3 uc001wpu.3) ENST00000546511 ENST00000550887
    ENST00000548369 ENST00000548182(uc001wpx.1) ENST00000358326
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate STXBP6:
    hsa-miR-34b* hsa-miR-548am hsa-miR-133b hsa-miR-578 hsa-miR-133a hsa-miR-548x hsa-miR-889 hsa-miR-449c
    SwitchGear 3'UTR luciferase reporter plasmidSTXBP6 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat STXBP6
      QuantiFast Probe-based Assays in human, mouse, rat STXBP6

    Additional mRNA sequence: 

    AF161505.1 AF391153.1 AK096957.1 AK309203.1 AL834346.1 BC009499.2 BC067278.1 

    8 DOTS entries:

    DT.95286519  DT.91756909  DT.100773366  DT.99930467  DT.120760833  DT.120760841  DT.100773365  DT.92041692 

    Selected AceView cDNA sequences (see all 140):

    AA256850 BE292897 BQ268942 BM738712 AI740751 AA309018 BM353657 BQ024551 
    BM479164 F09006 AI131058 AI092142 CA427015 BG167719 AA452801 CN480659 
    BX342811 W24272 W70308 NM_014178 AA452937 AA281449 BX350658 AW438612 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for STXBP6    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                    -           -           -                             -         
    SP2:                                                                                    
    SP3:                          -     -           -                             -         
    SP4:                    -     -     -           -                                       


    ECgene alternative splicing isoforms for STXBP6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STXBP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCATCACC
    STXBP6 Expression
    About this image


    STXBP6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Epiblast (Early Embryonic Tissues)
             Epiblast-like cells
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    STXBP6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STXBP6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.508958

    UniProtKB/Swiss-Prot: STXB6_HUMAN, Q8NFX7
    Tissue specificity: Detected at low levels in brain, and at very low levels in heart, adrenal gland, testis, liver
    and kidney

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STXBP6 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stxbp61 , 5 syntaxin binding protein 6 (amisyn)1, 5 92.86(n)1
    98.57(a)1
      12 (20.71 cM)5
    2175171  NM_144552.31  NP_653135.21 
     448524885 
    chicken
    (Gallus gallus)
    Aves STXBP61 syntaxin binding protein 6 (amisyn) 85.08(n)
    94.29(a)
      423299  NM_001199711.1  NP_001186640.1 
    lizard
    (Anolis carolinensis)
    Reptilia STXBP66
    syntaxin binding protein 6 (amisyn)
    91(a)
    1 ↔ 1
    1(30008532-30040594)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687962 hypothetical protein MGC68796 76.75(n)    BC060365.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stxbp61 syntaxin binding protein 6 (amisyn) 70.79(n)
    74.76(a)
      415153  NM_001002063.1  NP_001002063.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sec36
    sec3
    5(a)
    1 → many
    3L(17414887-17418317)
    worm
    (Caenorhabditis elegans)
    Secernentea sec-36
    Protein SEC-3 (sec-3) mRNA, complete cds
    6(a)
    1 → many
    X(3095437-3099837) WBGene00018703


    ENSEMBL Gene Tree for STXBP6 (if available)
    TreeFam Gene Tree for STXBP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STXBP6 gene
    EXOC12  
    1 SIMAP similar gene for STXBP6 using alignment to 2 protein entries:     STXB6_HUMAN (see all proteins):
    EXOC1

    Find genes that share paralogs with STXBP6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STXBP6 (see all 4474)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343714131,2
    C--5509670(+) ATATC-/TTTGGGC 1 -- int10--------
    rs1453025101,2
    C--25280884(+) ATAAAC/TAGATA 1 -- ds50010--------
    rs772720611,2
    F--25281015(+) TAAATC/GTACTA 1 -- ds50010--------
    rs1909752131,2
    --25281103(+) ACCAGC/TGACCA 1 -- ds50010--------
    rs2009287531,2
    C--25281166(+) TAGGC-/TTTTCT 1 -- ds50010--------
    rs751233681,2
    C--25281171(+) TTTTCC/TTTAGG 1 -- ds50010--------
    rs1996539091,2
    --25281171(+) TTTTC-/TTTAGG 1 -- ds50010--------
    rs1840127801,2
    --25281173(+) TTCTTC/TAGGGC 1 -- ds50010--------
    rs22970591,2
    C,F,H--25281213(+) ATAATA/TCCAAG 1 -- ds500114Minor allele frequency- N:0.00EA NA NS WA CSA 824
    rs1464964591,2
    C--25281217(+) TTCCAA/GGTAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for STXBP6 (25278862 - 25519503 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STXBP6 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv21738CNV Loss19812545
    nsv527684CNV Loss19592680
    esv25325CNV Loss19812545
    nsv901505CNV Gain21882294
    nsv901508CNV Gain21882294
    nsv901510CNV Gain21882294
    nsv525203CNV Gain19592680
    nsv901506CNV Gain21882294
    nsv901504CNV Gain21882294
    nsv456169CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607958    OMIM disorders: --


    Find genes that share disorders with STXBP6           About GenesLikeMe

    Genetic Association Database (GAD): STXBP6
    Human Genome Epidemiology (HuGE) Navigator: STXBP6 (1 document)

    Export disorders for STXBP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STXBP6 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with STXBP6)
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    1. Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly. (PubMed id 12145319)1, 2, 3 Scales S.J.... Scheller R.H. (J. Biol. Chem. 2002)
    2. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PubMed id 21738478)1, 4 Okada Y....Kamatani N. (PLoS Genet. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    7. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    8. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. CD6 and syntaxin binding protein 6 variants and response to tumor necrosis factor alpha inhibitors in Danish patients with rheumatoid arthritis. (PubMed id 22685579)1 Krintel S.B....Hetland M.L. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29091 HGNC: 19666 AceView: STXBP6 Ensembl:ENSG00000168952 euGenes: HUgn29091
    ECgene: STXBP6 H-InvDB: STXBP6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STXBP6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STXBP6 gene:
    Search GeneIP for patents involving STXBP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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