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Aliases for STXBP5L Gene

Aliases for STXBP5L Gene

  • Syntaxin Binding Protein 5-Like 2 3
  • LLGL4 3 4 6
  • Lethal(2) Giant Larvae Protein Homolog 4 3 4
  • Tomosyn-2 3 4
  • Syntaxin-Binding Protein 5-Like 3
  • Tomosyn-Like 3
  • KIAA1006 4

External Ids for STXBP5L Gene

Summaries for STXBP5L Gene

GeneCards Summary for STXBP5L Gene

STXBP5L (Syntaxin Binding Protein 5-Like) is a Protein Coding gene. GO annotations related to this gene include syntaxin binding. An important paralog of this gene is LLGL2.

UniProtKB/Swiss-Prot for STXBP5L Gene

  • May play a role in vesicle trafficking and exocytosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STXBP5L Gene

Genomics for STXBP5L Gene

Genomic Location for STXBP5L Gene

Start:
120,908,072 bp from pter
End:
121,424,761 bp from pter
Size:
516,690 bases
Orientation:
Plus strand

Genomic View for STXBP5L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STXBP5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STXBP5L Gene

Regulatory Elements for STXBP5L Gene

Proteins for STXBP5L Gene

  • Protein details for STXBP5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2K9-STB5L_HUMAN
    Recommended name:
    Syntaxin-binding protein 5-like
    Protein Accession:
    Q9Y2K9
    Secondary Accessions:
    • Q4G1B4
    • Q6PIC3

    Protein attributes for STXBP5L Gene

    Size:
    1186 amino acids
    Molecular mass:
    131887 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76850.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STXBP5L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STXBP5L Gene

Proteomics data for STXBP5L Gene at MOPED

Post-translational modifications for STXBP5L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STXBP5L Gene

Domains for STXBP5L Gene

Gene Families for STXBP5L Gene

HGNC:
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

STB5L_HUMAN
Domain:
  • Contains 1 v-SNARE coiled-coil homology domain.:
    • Q9Y2K9
Family:
  • Belongs to the WD repeat L(2)GL family.:
    • Q9Y2K9
Similarity:
  • Contains 14 WD repeats.:
    • Q9Y2K9
genes like me logo Genes that share domains with STXBP5L: view

Function for STXBP5L Gene

Molecular function for STXBP5L Gene

UniProtKB/Swiss-Prot Function: May play a role in vesicle trafficking and exocytosis.

Gene Ontology (GO) - Molecular Function for STXBP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019905 syntaxin binding IEA --
genes like me logo Genes that share ontologies with STXBP5L: view

Phenotypes for STXBP5L Gene

MGI mutant phenotypes for STXBP5L:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with STXBP5L: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for STXBP5L Gene

Localization for STXBP5L Gene

Subcellular locations from UniProtKB/Swiss-Prot for STXBP5L Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Membrane; Peripheral membrane protein. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STXBP5L Gene COMPARTMENTS Subcellular localization image for STXBP5L gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for STXBP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STXBP5L: view

Pathways for STXBP5L Gene

SuperPathways for STXBP5L Gene

No Data Available

Interacting Proteins for STXBP5L Gene

Gene Ontology (GO) - Biological Process for STXBP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport --
GO:0017157 regulation of exocytosis IEA --
GO:0042593 glucose homeostasis IEA --
genes like me logo Genes that share ontologies with STXBP5L: view

No data available for Pathways by source for STXBP5L Gene

Transcripts for STXBP5L Gene

mRNA/cDNA for STXBP5L Gene

Unigene Clusters for STXBP5L Gene

Syntaxin binding protein 5-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STXBP5L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2:

ExUns: 25 ^ 26 ^ 27 ^ 28
SP1:
SP2:

Relevant External Links for STXBP5L Gene

GeneLoc Exon Structure for
STXBP5L
ECgene alternative splicing isoforms for
STXBP5L

Expression for STXBP5L Gene

mRNA expression in normal human tissues for STXBP5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STXBP5L Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (11.2), Brain - Cerebellum (10.5), Brain - Frontal Cortex (BA9) (5.0), and Brain - Cortex (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STXBP5L Gene

SOURCE GeneReport for Unigene cluster for STXBP5L Gene Hs.477315

mRNA Expression by UniProt/SwissProt for STXBP5L Gene

Q9Y2K9-STB5L_HUMAN
Tissue specificity: Detected in kidney, hippocampus and lung carcinoma.
genes like me logo Genes that share expressions with STXBP5L: view

Orthologs for STXBP5L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STXBP5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STXBP5L 36
  • 99.92 (n)
  • 100 (a)
STXBP5L 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STXBP5L 36
  • 94.12 (n)
  • 97.55 (a)
STXBP5L 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STXBP5L 36
  • 94.97 (n)
  • 97.13 (a)
STXBP5L 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stxbp5l 36
  • 90.97 (n)
  • 95.53 (a)
Stxbp5l 16
Stxbp5l 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STXBP5L 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STXBP5L 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stxbp5l 36
  • 90.52 (n)
  • 95.86 (a)
chicken
(Gallus gallus)
Aves STXBP5L 36
  • 81.32 (n)
  • 87.79 (a)
STXBP5L 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STXBP5L 37
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stxbp5l 36
  • 73.66 (n)
  • 81.75 (a)
zebrafish
(Danio rerio)
Actinopterygii stxbp5l 36
  • 68.14 (n)
  • 74.4 (a)
stxbp5l 37
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tomosyn 37
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tom-1 36
  • 49.2 (n)
  • 38.03 (a)
tom-1 37
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRO7 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToMany
Species with no ortholog for STXBP5L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STXBP5L Gene

ENSEMBL:
Gene Tree for STXBP5L (if available)
TreeFam:
Gene Tree for STXBP5L (if available)

Paralogs for STXBP5L Gene

Paralogs for STXBP5L Gene

Selected SIMAP similar genes for STXBP5L Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with STXBP5L: view

Variants for STXBP5L Gene

Sequence variations from dbSNP and Humsavar for STXBP5L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs168117 -- 121,300,588(-) catct(A/G)tttgt intron-variant
rs168118 -- 121,253,828(-) aaaat(A/C)caaaa intron-variant
rs170939 -- 121,216,508(-) actcc(A/C)gtggt intron-variant
rs173086 -- 121,226,681(-) agatt(C/T)tgaat intron-variant
rs173087 -- 121,218,922(-) ACTGA(C/G)GACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STXBP5L Gene

Variant ID Type Subtype PubMed ID
nsv829700 CNV Gain+Loss 17160897
esv2557637 CNV Deletion 19546169
esv2725831 CNV Deletion 23290073
esv2675253 CNV Deletion 23128226
nsv829701 CNV Gain 17160897
dgv296n21 CNV Loss 19592680
nsv521397 CNV Gain 19592680
nsv829702 CNV Gain 17160897
esv2669340 CNV Deletion 23128226

Relevant External Links for STXBP5L Gene

HapMap Linkage Disequilibrium report
STXBP5L
Human Gene Mutation Database (HGMD)
STXBP5L

Disorders for STXBP5L Gene

Relevant External Links for STXBP5L

Genetic Association Database (GAD)
STXBP5L
Human Genome Epidemiology (HuGE) Navigator
STXBP5L
genes like me logo Genes that share disorders with STXBP5L: view

No data available for UniProtKB/Swiss-Prot for STXBP5L Gene

Publications for STXBP5L Gene

  1. Identification and characterization of human LLGL4 gene and mouse Llgl4 gene in silico. (PMID: 14767561) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 4 23
  2. Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection. (PMID: 19586676) Li Y. … Sninsky J. (J. Hepatol. 2009) 3 23 49
  3. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for STXBP5L Gene

Sources for STXBP5L Gene

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