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STXBP5-AS1 Gene

RNA gene GIFtS: 17
GCID: GC06M147162

STXBP5 Antisense RNA 1

(Previous name: STXBP5 antisense RNA 1 (non-protein coding))

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 5.2

Aliases
STXBP5 Antisense RNA 1¹ ²
STXBP5 Antisense RNA 1 (Non-Protein Coding)¹

External Ids:	HGNC: 44183¹	Entrez Gene: 729178²	Ensembl: ENSG00000233452⁷

ORGUL members:	fRNAdb¹⁰:FR220867 FR272899 FR135941 FR229586 FR091579
	NCBI¹³:BC035182
	NONCODE¹⁴:n378248 n409714 n385031 n377949 n378697	see all 9
	RNAdb¹⁵:EVF6659 EVF39667 EVF17055 EVF21116 ASO3892	see all 9

Export aliases for STXBP5-AS1 gene to outside databases

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STXBP5-AS1 Gene:

STXBP5-AS1 (STXBP5 antisense RNA 1) is an RNA gene, and is affiliated with the lncRNA class.

fRNAdb sequence ontologies for STXBP5-AS1 - the ORGUL cluster for this gene includes several descriptions:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.
antisense_RNA - Antisense RNA is RNA that is transcribed from the coding, rather than the template, strand of DNA. It is therefore complementary to mRNA.

View fRNAdb secondary structures for STXBP5-AS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000006.11 NC_018917.2 NT_025741.16

Regulatory elements:

Search for regulatory transcription factor binding sites for STXBP5-AS1
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Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STXBP5-AS1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.3 Ensembl cytogenetic band: 6q24.3 HGNC cytogenetic band: 6q24.3

STXBP5-AS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STXBP5-AS1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M147162: view genomic region (about GC identifiers)

Start:	147,162,524 bp from pter	End:	147,525,750 bp from pter
Size:	363,227 bases	Orientation:	minus strand

ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for STXBP5-AS1

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB: --

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

LNCRNA: Long non-coding RNAs

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
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5/6 fRNAdb Secondary structures (see all 6):

Unigene Cluster for STXBP5-AS1:

STXBP5 antisense RNA 1

Hs.557608 [show with all ESTs]

Unigene Representative Sequence: NR_034115

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000606831(antisense) ENST00000427394(antisense) ENST00000367477(antisense) ENST00000433308(antisense) ENST00000447072(antisense)

ENST00000458125(antisense) ENST00000443712(antisense) ENST00000431143(antisense) ENST00000417502(antisense)

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Additional mRNA sequence:

AK091594.1 AK125216.1 BC035182.2 BC044307.1 NR_034115.1

8 DOTS entries:

DT.40206386 DT.95290977 DT.303352 DT.100670277 DT.95230319 DT.40308467 DT.121321072 DT.40225321

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for STXBP5-AS1:none

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

STXBP5-AS1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

--

SOURCE GeneReport for Unigene cluster: Hs.557608

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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--

ENSEMBL Gene Tree for STXBP5-AS1 (if available)
TreeFam Gene Tree for STXBP5-AS1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs67828530^1,2	C	--	144880808(+)	`TTAAC-/GT/TG TATTG`	1	--	int¹		0	--	--	--	--
rs56844411^1,2	C	--	145060917(+)	`AAAAA-/A/AA CCCTG`	1	--	int¹		1		NA	2
rs1324680^1,2	C,F,A	--	147162027(+)	`GAGTGT/CTGCCA`	1	--	int¹		10		WA NA CSA EA	370
rs112339786^1,2	C	--	147162044(+)	`ATTCA-/CT/TC TGAGT`	1	--	int¹		1		CSA	2
rs60603956^1,2	C	--	147162045(+)	`TTCAT-/CT/TC GAGTC`	1	--	int¹		0	--	--	--	--
rs76990224^1,2		--	147162098(+)	`GCCGAC/TGAGCG`	1	--	int¹		0	--	--	--	--
rs149634030^1,2		--	147162227(+)	`TTCAGA/GGTTTC`	1	--	int¹		0	--	--	--	--
rs1324681^1,2	C,F,O,A,H	--	147162249(+)	`ATTCCC/TGTGAC`	1	--	int¹		23		MN NS EA NA WA	2948
rs183313040^1,2		--	147162401(+)	`AAAGGC/GTTACT`	1	--	int¹		0	--	--	--	--
rs187308270^1,2		--	147162456(+)	`AGCAGG/TAGTGT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for STXBP5-AS1 (147162524 - 147412524 bp, first 250kb of STXBP5-AS1)

Structural Variations
Database of Genomic Variants (DGV) variations for STXBP5-AS1: --

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM information: 180902 609850 608712

Find genes that share disorders with STXBP5-AS1 About GenesLikeMe

Export disorders for STXBP5-AS1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for STXBP5-AS1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with STXBP5-AS1)

Utopia: connect your pdf to the dynamic
world of online information

Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (Nat. Genet. 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
(PubMed id 16628248)¹⁰
(PubMed id 15608161)¹⁰

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 729178	HGNC: 44183	Ensembl:ENSG00000233452	euGenes: HUgn729178	ECgene: STXBP5-AS1
H-InvDB: STXBP5-AS1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Intellectual Property for STXBP5-AS1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for STXBP5-AS1 gene:
Search GeneIP for patents involving STXBP5-AS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Aliases
for STXBP5-AS1 gene

Summaries
for STXBP5-AS1 gene

Genomic Views
for STXBP5-AS1 gene

Proteins
for STXBP5-AS1 gene

Domains /
Families
for STXBP5-AS1 gene

Function
for STXBP5-AS1 gene

Localization
for STXBP5-AS1 gene

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for STXBP5-AS1 gene

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for STXBP5-AS1 gene

Transcripts
for STXBP5-AS1 gene

Expression
for STXBP5-AS1 gene

Orthologs
for STXBP5-AS1 gene

Paralogs
for STXBP5-AS1 gene

Genomic Variants
for STXBP5-AS1 gene

Disorders / Diseases
for STXBP5-AS1 gene

Publications
for STXBP5-AS1 gene

Intellectual Property
for STXBP5-AS1 gene

Products
for STXBP5-AS1 gene