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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STXBP5 Gene

protein-coding   GIFtS: 54
GCID: GC06P147566

syntaxin binding protein 5 (tomosyn)

 Explore 7 diseases affiliated with
STXBP5 via our new
 Human Malady Compendium 
Biological research products
for STXBP5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Syntaxin Binding Protein 5 (Tomosyn)1 2     Nbla043002
LLGL31 2 3     Putative Protein Product Of Nbla043002
Tomosyn1     Syntaxin-Binding Protein 52
Lethal(2) Giant Larvae Protein Homolog 32 3     Tomosyn-13
LGL32     Tomosyn-13

External Ids:    HGNC: 196651   Entrez Gene: 1349572   Ensembl: ENSG000001645067   OMIM: 6045865   UniProtKB: Q5T5C03   

Export aliases for STXBP5 gene to outside databases

Previous GC identifers: GC06P147372 GC06P147461 GC06P147505 GC06P145089


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STXBP5:
Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic
vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar
protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can
be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by
stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been
identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: STXB5_HUMAN, Q5T5C0
Function: Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane
fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between
transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma
membrane. Competes with STXBP1 for STX1 binding (By similarity)

Gene Wiki entry for STXBP5


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STXBP5 gene promoter:
         Elk-1   RP58   C/EBPbeta   GATA-3   FOXJ2 (long isoform)   CUTL1   FOXJ2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTXBP5 promoter sequence
   Search SABiosciences Chromatin IP Primers for STXBP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STXBP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.3   Ensembl cytogenetic band:  6q24.3   HGNC cytogenetic band: 6q24.3

STXBP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STXBP5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P147566:  view genomic region     (about GC identifiers)

Start:
147,525,508 bp from pter      End:
147,708,707 bp from pter
Size:
183,200 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STXB5_HUMAN, Q5T5C0 (See protein sequence)
Recommended Name: Syntaxin-binding protein 5  
Size: 1151 amino acids; 127573 Da
Subunit: Interacts with STX1A and STX1B via its v-SNARE homology domain. Part of a complex that contains STX1, STXBP5,
SNAP25 and SYT1. Part of a complex that contains STXBP5, STX4A and SNAP23 (By similarity)
Subcellular location: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity).
Cytoplasmic vesicle membrane; Peripheral membrane protein (By similarity). Cytoplasmic vesicle, secretory vesicle,
synaptic vesicle (By similarity). Cell junction, synapse (By similarity). Note=Cytoplasmic, and associated with
vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles (By similarity)
Sequence caution: Sequence=BAC03475.1; Type=Erroneous initiation;
Secondary accessions: Q14DF3 Q5T5C1 Q5T5C2 Q8NBG8 Q96NG9
Alternative splicing: 3 isoforms:  Q5T5C0-1   Q5T5C0-2   Q5T5C0-3   

Explore the universe of human proteins at neXtProt for STXBP5: NX_Q5T5C0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5T5C0

  • STXBP5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001121187.1  NP_640337.3  

    ENSEMBL proteins: 
     ENSP00000356451   ENSP00000321826   ENSP00000356450   ENSP00000356445   ENSP00000376112  
     ENSP00000441479   ENSP00000179882  

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    Uscn Proteins for STXBP5

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005892acetylcholine-gated channel complex ISS--
    GO:0008021synaptic vesicle IEA--
    GO:0016021integral to membrane ----
    GO:0030054cell junction IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--


    STXBP5 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    STXBP5 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR013905 Lgl_C
     IPR001388 Synaptobrevin
     IPR000664 Lethal2_giant

    Graphical View of Domain Structure for InterPro Entry Q5T5C0

    ProtoNet protein and cluster: Q5T5C0

    2 Blocks protein families:
    IPB000664 Lethal(2) giant larvae protein signature
    IPB001388 Synaptobrevin


    UniProtKB/Swiss-Prot: STXB5_HUMAN, Q5T5C0
    Similarity: Belongs to the WD repeat L(2)GL family
    Similarity: Contains 1 v-SNARE coiled-coil homology domain
    Similarity: Contains 14 WD repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: STXB5_HUMAN, Q5T5C0
    Function: Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane
    fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between
    transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma
    membrane. Competes with STXBP1 for STX1 binding (By similarity)

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    hsa-miR-19b-2* hsa-let-7d hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-30d hsa-miR-519a hsa-miR-374c
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0017075syntaxin-1 binding ISS--
    GO:0019905syntaxin binding ----


    STXBP5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for STXBP5:
     Decreased viability with cispl 

    Animal Models:
         Mouse knock-out Stxbp5tm1Ytk for STXBP5
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Stxbp5):
     mortality/aging  nervous system 

    STXBP5 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STXBP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/21 Interacting proteins for STXBP5 (Q5T5C03 ENSP000003218264) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX4Q128463, ENSP000003177144I2D: score=3 STRING: ENSP00000317714
    STX1AQ166233, ENSP000002228124I2D: score=3 STRING: ENSP00000222812
    SNAP23O001613, ENSP000002496474I2D: score=3 STRING: ENSP00000249647
    SNAP25P608803, ENSP000002549764I2D: score=2 STRING: ENSP00000254976
    ARRB1P494073I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IEA--
    GO:0015031protein transport IEA--
    GO:0016192vesicle-mediated transport ----
    GO:0045921positive regulation of exocytosis ISS--


    STXBP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for STXBP5

    1 HMDB Compound for STXBP5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about STXBP5 / STXB5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STXBP5 gene (2 alternative transcripts): 
    NM_001127715.2  NM_139244.4  

    Unigene Cluster for STXBP5:

    Syntaxin binding protein 5 (tomosyn)
    Hs.86320  [show with all ESTs]
    Unigene Representative Sequence: NM_001127715
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367481(uc003qlz.3 uc010khz.2 uc003qly.3) ENST00000321680(uc003qma.3)
    ENST00000367480 ENST00000367475 ENST00000392291 ENST00000546097 ENST00000179882


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    hsa-miR-19b-2* hsa-let-7d hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-30d hsa-miR-519a hsa-miR-374c
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB073398.1 AK055484.1 AK090549.1 AK128121.1 AL834152.1 BC043645.1 BC065713.1 BC107737.1 
    BC113382.1 BC113408.1 

    15 DOTS entries:

    DT.214463  DT.405328  DT.100780264  DT.100780265  DT.40118919  DT.99980269  DT.95290977  DT.121321101 
    DT.91944232  DT.100659436  DT.426292  DT.91816602  DT.99976280  DT.303352  DT.75169291 

    24/176 AceView cDNA sequences (see all 176):

    CB140025 AW675432 BU621777 BU166049 BU101951 R05649 CA418716 AK128121 
    AL834152 AA960970 AI149232 BG696027 BI491180 AW675425 BG236421 AA588329 
    AA653367 AA766450 BX506766 AK090549 CD558953 BX457350 AW674014 AW674797 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for STXBP5 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
    SP1:                                            -                       -                                                                                   -   
    SP2:                                                                    -                                                                             -     -   
    SP3:                                                                                                                                            -     -     -   
    SP4:                                                                                                                                                        -   
    SP5:                                            -                                                                                                               

    ExUns: 24b ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31a · 31b
    SP1:        -                                                               
    SP2:  -     -                                                               
    SP3:  -     -                                                               
    SP4:  -     -                                                               
    SP5:                                                                        


    ECgene alternative splicing isoforms for STXBP5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STXBP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGTGGCTAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See STXBP5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STXBP5

    SOURCE GeneReport for Unigene cluster: Hs.86320
        SABiosciences Custom PCR Arrays for STXBP5
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STXBP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for STXBP5 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves STXBP51 syntaxin binding protein 5 (tomosyn) 84.8(n)
    93.92(a)
      421620  XM_003640994.1  XP_003641042.1 
    lizard
    (Anolis carolinensis)
    Reptilia STXBP56
    --
    91(a)
    1 ↔ 1
    1(207863474-208028348)
    zebrafish
    (Danio rerio)
    Actinopterygii stxbp5a1 syntaxin binding protein 5a (tomosyn) 72.56(n)
    81.42(a)
      556789  NM_001099981.2  NP_001093451.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tomosyn1 CG17762-PC 51.75(n)
    49.16(a)
      32217  NM_001169264.1  NP_001162735.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tom-11 Protein TOM-1 47.01(n)
    38.14(a)
      172209  NM_001129023.1  NP_001122495.1 


    ENSEMBL Gene Tree for STXBP5 (if available)
    TreeFam Gene Tree for STXBP5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STXBP5 gene
    LLGL22  LLGL12  STXBP5L2  
    4 SIMAP similar genes for STXBP5 using alignment to 6 protein entries:     STXB5_HUMAN (see all proteins):
    Nbla04300    STXBP5L    LLGL2    LLGL1

    STXBP5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2771 NCBI SNPs in STXBP5 are shown (see all 2771    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs777977541,2
    C--147523639(+) ATTTCC/GCGAAA 3 -- int1 us2k10--------
    rs769568221,2
    C--147523640(+) TTTCCC/TGAAAT 3 -- us2k1 int10--------
    rs755459221,2
    C--147523641(+) TTCCCC/GAAATC 3 -- us2k1 int10--------
    rs759609171,2
    C--147523643(+) CCCGAA/GATCCC 3 -- us2k1 int10--------
    rs94851511,2
    C,H--147523785(+) TGGAAC/TTTAAA 3 -- int1 us2k15Minor allele frequency- T:0.00NS EA NA 418
    rs1142535441,2
    --147524081(+) GTGCGG/ACCTCG 3 -- us2k1 int11Minor allele frequency- A:0.01WA 118
    rs1382186371,2
    --147524223(+) TTCCTA/GCCACC 3 -- int1 us2k10--------
    rs1901944831,2
    --147524239(+) TCCTCA/CCCGGC 3 -- int1 us2k10--------
    rs5591641,2
    C,--147524298(-) AACGGC/TTCCAG 3 -- int1 us2k111Minor allele frequency- T:0.00NA WA CSA EA 371
    rs800852801,2
    F,--147524355(+) GACACG/CTTCCA 3 -- us2k1 int11Minor allele frequency- C:0.10WA 118

    HapMap Linkage Disequilibrium report for STXBP5 (147525508 - 147708707 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for STXBP5
         1 CNV: 99746
    Human Gene Mutation Database (HGMD): STXBP5

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STXBP5
    DNA2.0 Custom Variant and Variant Library Synthesis for STXBP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    STXBP5 for disorders           About GeneDecksing

    OMIM gene information: 604586    OMIM disorders: --

    7 diseases for STXBP5:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    thrombosis    lung cancer
    tuberculosis    neuronitis    venous thrombosis

    Human Genome Epidemiology (HuGE) Navigator: STXBP5 (3 documents)

    Export disorders for STXBP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STXBP5 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with STXBP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human LLGL4 gene and mouse Llgl4 gene in silico. (PubMed id 14767561)1, 3, 9 Katoh M. and Katoh M. (2004)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. (PubMed id 9620695)1, 3 Fujita Y....Takai Y. (1998)
    6. Effect of genetic variation in STXBP5 and STX2 on von Willebrand factor and bleeding phenotype in type 1 von Willebrand disease patien ts. (PubMed id 22792389)1 van Loon J.E....Leebeek F.W. (2012)
    7. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    8. Structural and functional analysis of tomosyn identif ies domains important in exocytotic regulation. (PubMed id 21330375)1 Williams A.L....Stuenkel E.L. (2011)
    9. Genetic variation associated with plasma von Willebra nd factor levels and the risk of incident venous thrombosis. (PubMed id 21163921)1 Smith N.L....Rosendaal F.R. (2011)
    10. Effect of genetic variations in syntaxin-binding prot ein-5 and syntaxin-2 on von Willebrand factor concentration and cardiovascular risk. (PubMed id 21156930)1 van Loon J.E....de Maat M.P. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 134957 HGNC: 19665 AceView: STXBP5 Ensembl:ENSG00000164506 euGenes: HUgn134957
    ECgene: STXBP5 H-InvDB: STXBP5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STXBP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STXBP5 gene:
    Search GeneIP for patents involving STXBP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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