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Aliases for STXBP4 Gene

Aliases for STXBP4 Gene

  • Syntaxin Binding Protein 4 2 3 5
  • Syntaxin 4-Interacting Protein 3 4
  • STX4-Interacting Protein 3 4
  • Synip 3 4
  • Syntaxin 4 Interacting Protein 3
  • Syntaxin-Binding Protein 4 3

External Ids for STXBP4 Gene

Previous GeneCards Identifiers for STXBP4 Gene

  • GC00U906275
  • GC17P053405
  • GC17P053520
  • GC17P050401
  • GC17P053046
  • GC17P048405

Summaries for STXBP4 Gene

GeneCards Summary for STXBP4 Gene

STXBP4 (Syntaxin Binding Protein 4) is a Protein Coding gene. Among its related pathways are Insulin Signaling and Glucose / Energy Metabolism. GO annotations related to this gene include calcium ion binding and syntaxin binding.

UniProtKB/Swiss-Prot for STXBP4 Gene

  • Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STXBP4 Gene

Genomics for STXBP4 Gene

Regulatory Elements for STXBP4 Gene

Enhancers for STXBP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around STXBP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for STXBP4 Gene

Chromosome:
17
Start:
54,968,727 bp from pter
End:
55,173,632 bp from pter
Size:
204,906 bases
Orientation:
Plus strand

Genomic View for STXBP4 Gene

Genes around STXBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STXBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STXBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STXBP4 Gene

Proteins for STXBP4 Gene

  • Protein details for STXBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZWJ1-STXB4_HUMAN
    Recommended name:
    Syntaxin-binding protein 4
    Protein Accession:
    Q6ZWJ1
    Secondary Accessions:
    • Q8IVZ5

    Protein attributes for STXBP4 Gene

    Size:
    553 amino acids
    Molecular mass:
    61662 Da
    Quaternary structure:
    • Interacts with STX4A.

    Three dimensional structures from OCA and Proteopedia for STXBP4 Gene

    Alternative splice isoforms for STXBP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STXBP4 Gene

Post-translational modifications for STXBP4 Gene

  • Phosphorylated on Ser-99 by PKB/AKT2 after insulin treatment. Phosphorylation on Ser-99 abolishes the interaction with STX4A (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STXBP4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STXBP4 (STXBP4)

No data available for DME Specific Peptides for STXBP4 Gene

Domains & Families for STXBP4 Gene

Gene Families for STXBP4 Gene

Protein Domains for STXBP4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STXBP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZWJ1

UniProtKB/Swiss-Prot:

STXB4_HUMAN :
  • Contains 1 PDZ (DHR) domain.
Domain:
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 WW domain.
genes like me logo Genes that share domains with STXBP4: view

Function for STXBP4 Gene

Molecular function for STXBP4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity).

Gene Ontology (GO) - Molecular Function for STXBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19451233
GO:0019905 syntaxin binding IPI 12855681
genes like me logo Genes that share ontologies with STXBP4: view
genes like me logo Genes that share phenotypes with STXBP4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STXBP4 Gene

Localization for STXBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STXBP4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STXBP4 Gene COMPARTMENTS Subcellular localization image for STXBP4 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 5
cytosol 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for STXBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with STXBP4: view

Pathways & Interactions for STXBP4 Gene

genes like me logo Genes that share pathways with STXBP4: view

Pathways by source for STXBP4 Gene

1 Cell Signaling Technology pathway for STXBP4 Gene
2 BioSystems pathways for STXBP4 Gene

Gene Ontology (GO) - Biological Process for STXBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0006974 cellular response to DNA damage stimulus IDA 19451233
GO:0008286 insulin receptor signaling pathway IEA --
GO:0010838 positive regulation of keratinocyte proliferation IMP 19451233
GO:0015758 glucose transport IEA --
genes like me logo Genes that share ontologies with STXBP4: view

No data available for SIGNOR curated interactions for STXBP4 Gene

Drugs & Compounds for STXBP4 Gene

No Compound Related Data Available

Transcripts for STXBP4 Gene

Unigene Clusters for STXBP4 Gene

Syntaxin binding protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STXBP4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for STXBP4 Gene

GeneLoc Exon Structure for
STXBP4
ECgene alternative splicing isoforms for
STXBP4

Expression for STXBP4 Gene

mRNA expression in normal human tissues for STXBP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STXBP4 Gene

This gene is overexpressed in Liver (42.0), Kidney (11.6), and CD4 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STXBP4 Gene



NURSA nuclear receptor signaling pathways regulating expression of STXBP4 Gene:

STXBP4

SOURCE GeneReport for Unigene cluster for STXBP4 Gene:

Hs.35199
genes like me logo Genes that share expression patterns with STXBP4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for STXBP4 Gene

Orthologs for STXBP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STXBP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STXBP4 34
  • 88.59 (n)
  • 84.24 (a)
-- 35
  • 77 (a)
OneToMany
STXBP4 35
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia STXBP4 34
  • 89.61 (n)
  • 86.05 (a)
STXBP4 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stxbp4 34
  • 82.19 (n)
  • 77.17 (a)
Stxbp4 16
Stxbp4 35
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STXBP4 34
  • 99.46 (n)
  • 98.73 (a)
STXBP4 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stxbp4 34
  • 78.4 (n)
  • 72.96 (a)
oppossum
(Monodelphis domestica)
Mammalia STXBP4 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STXBP4 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves STXBP4 34
  • 67.1 (n)
  • 61.64 (a)
STXBP4 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STXBP4 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7468 34
stxbp4 34
  • 63.26 (n)
  • 55.62 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC567916 34
  • 55.26 (n)
  • 48.37 (a)
stxbp4 35
  • 33 (a)
OneToOne
Species where no ortholog for STXBP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STXBP4 Gene

ENSEMBL:
Gene Tree for STXBP4 (if available)
TreeFam:
Gene Tree for STXBP4 (if available)

Paralogs for STXBP4 Gene

(1) SIMAP similar genes for STXBP4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STXBP4: view

No data available for Paralogs for STXBP4 Gene

Variants for STXBP4 Gene

Sequence variations from dbSNP and Humsavar for STXBP4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34870302 - 54,999,702(-) TGTAC(A/C/G)TGACA nc-transcript-variant, reference, missense
rs1156287 - 54,999,438(-) GGCTC(C/T)GGTAA nc-transcript-variant, reference, missense
rs171510 -- 55,134,166(+) AAAGC(A/G)GAGTG intron-variant
rs171513 -- 55,113,065(+) GATTC(A/G)TATGG intron-variant
rs171514 -- 55,108,473(+) ctgca(A/G)ctagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STXBP4 Gene

Variant ID Type Subtype PubMed ID
dgv3266n100 CNV loss 25217958
dgv5708n54 CNV loss 21841781
esv2478056 CNV deletion 19546169
esv3582823 CNV loss 25503493
esv3640830 CNV gain 21293372
esv3640834 CNV loss 21293372
nsv1058348 CNV loss 25217958
nsv1160495 CNV duplication 26073780
nsv457853 CNV loss 19166990
nsv515749 CNV loss 19592680
nsv522299 CNV loss 19592680
nsv575661 CNV loss 21841781
nsv833489 CNV gain 17160897

Variation tolerance for STXBP4 Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STXBP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STXBP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STXBP4 Gene

Disorders for STXBP4 Gene

Relevant External Links for STXBP4

Genetic Association Database (GAD)
STXBP4
Human Genome Epidemiology (HuGE) Navigator
STXBP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STXBP4

No disorders were found for STXBP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STXBP4 Gene

Publications for STXBP4 Gene

  1. Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cell. (PMID: 12855681) Saito T. … Mori M. (J. Biol. Chem. 2003) 2 3 22 65
  2. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PMID: 20095854) Bhatti P. … Sigurdson A.J. (Radiat. Res. 2010) 3 46 65
  3. Common genetic variants associated with breast cancer and mammographic density measures that predict disease. (PMID: 20145138) Odefrey F. … Southey M.C. (Cancer Res. 2010) 3 46 65
  4. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban H.J. … Park K.J. (BMC Genet. 2010) 3 46 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for STXBP4 Gene

Sources for STXBP4 Gene

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