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STXBP4 Gene

protein-coding   GIFtS: 57
GCID: GC17P053046

Syntaxin Binding Protein 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Syntaxin Binding Protein 41 2
Syntaxin 4-Interacting Protein2 3
Synip2 3
STX4-Interacting Protein2 3
Syntaxin 4 Interacting Protein2
Syntaxin-Binding Protein 42

External Ids:    HGNC: 196941   Entrez Gene: 2529832   Ensembl: ENSG000001662637   OMIM: 6104155   UniProtKB: Q6ZWJ13   

Export aliases for STXBP4 gene to outside databases

Previous GC identifers: GC00U906275 GC17P053405 GC17P053520 GC17P050401 GC17P048405


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STXBP4 Gene:
STXBP4 (syntaxin binding protein 4) is a protein-coding gene. GO annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot: STXB4_HUMAN, Q6ZWJ1
Function: Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane.
Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and
preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A,
leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin
release by pancreatic beta cells after stimulation by glucose (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STXBP4 gene promoter:
         Oct-B1   Max1   oct-B2   MEF-2   FOXD1   CUTL1   MEF-2A   ARP-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTXBP4 promoter sequence
   Search Chromatin IP Primers for STXBP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STXBP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q22

STXBP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STXBP4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P053046:  view genomic region     (about GC identifiers)

Start:
53,046,088 bp from pter      End:
53,241,646 bp from pter
Size:
195,559 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: STXB4_HUMAN, Q6ZWJ1 (See protein sequence)
Recommended Name: Syntaxin-binding protein 4  
Size: 553 amino acids; 61662 Da
Subunit: Interacts with STX4A (By similarity)
1 PDB 3D structure from and Proteopedia for STXBP4:
2YSG (3D)    
Secondary accessions: Q8IVZ5
Alternative splicing: 2 isoforms:  Q6ZWJ1-1   Q6ZWJ1-2   

Explore the universe of human proteins at neXtProt for STXBP4: NX_Q6ZWJ1

Explore proteomics data for STXBP4 at MOPED

Post-translational modifications: 

  • Phosphorylated on Ser-99 by PKB/AKT2 after insulin treatment. Phosphorylation on Ser-99 abolishes the interaction
    with STX4A (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STXBP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_848604.3  
    ENSEMBL proteins: 
     ENSP00000365530   ENSP00000385944   ENSP00000391087   ENSP00000381427   ENSP00000468799  
     ENSP00000299341  

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    Cloud-Clone Corp. Proteins for STXBP4

     
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    antibodies-online proteins for STXBP4 (4 products) 

     
    antibodies-online peptides for STXBP4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR001478 PDZ
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry Q6ZWJ1

    ProtoNet protein and cluster: Q6ZWJ1

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: STXB4_HUMAN, Q6ZWJ1
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 WW domain


    Find genes that share domains with STXBP4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STXB4_HUMAN, Q6ZWJ1
    Function: Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane.
    Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and
    preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A,
    leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin
    release by pancreatic beta cells after stimulation by glucose (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with STXBP4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for STXBP4:
     Decreased influenza A/WSN/33 r  Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for STXBP4

    miRNA
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    miRTarBase miRNAs that target STXBP4:
    hsa-mir-324-5p (MIRT043123), hsa-mir-192-5p (MIRT026794)

    Block miRNA regulation of human, mouse, rat STXBP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STXBP4 (see all 51):
    hsa-miR-219-1-3p hsa-miR-100* hsa-miR-3653 hsa-miR-218 hsa-miR-371-5p hsa-miR-3921 hsa-miR-548l hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidSTXBP4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat STXBP4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STXB4_HUMAN, Q6ZWJ1: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    nucleus4
    cytosol3
    plasma membrane2
    endosome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0045111intermediate filament cytoskeleton IDA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with STXBP4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STXBP4 About    
    See pathways by source

    SuperPathContained pathways About
    1Insulin Signaling
    Insulin Signaling
    2Insulin-mediated glucose transport
    Insulin-mediated glucose transport
    3Glucose / Energy Metabolism
    Glucose / Energy Metabolism


    Find genes that share SuperPaths with STXBP4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for STXBP4
        Glucose / Energy Metabolism

    2 BioSystems Pathways for STXBP4
        Insulin Signaling
    Insulin-mediated glucose transport


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STXBP4
    Interactions:

        GeneGlobe Interaction Network for STXBP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for STXBP4 (Q6ZWJ12, 3 ENSP000003655304) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATN1P542592, 3, ENSP000003490764MINT-2879213 MINT-2879232 I2D: score=3 STRING: ENSP00000349076
    STX4Q128463, ENSP000003177144I2D: score=2 STRING: ENSP00000317714
    LNPEPENSP000002313684STRING: ENSP00000231368
    SLC2A4ENSP000003209354STRING: ENSP00000320935
    VAMP2ENSP000003142144STRING: ENSP00000314214
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006605protein targeting IEA--
    GO:0008286insulin receptor signaling pathway IEA--
    GO:0015758glucose transport IEA--

    Find genes that share ontologies with STXBP4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STXBP4 (STXB4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STXBP4 gene: 
    NM_178509.5  

    Unigene Cluster for STXBP4:

    Syntaxin binding protein 4
    Hs.35199  [show with all ESTs]
    Unigene Representative Sequence: NM_178509
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461444 ENST00000376352(uc002iuf.1 uc010dcd.1) ENST00000405898
    ENST00000434978 ENST00000464340 ENST00000398391(uc010dcc.1) ENST00000463234
    ENST00000468837 ENST00000299341
    miRNA
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    Block miRNA regulation of human, mouse, rat STXBP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STXBP4 (see all 51):
    hsa-miR-219-1-3p hsa-miR-100* hsa-miR-3653 hsa-miR-218 hsa-miR-371-5p hsa-miR-3921 hsa-miR-548l hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidSTXBP4 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat STXBP4

    Additional mRNA sequence: 

    AK122865.1 AK123793.1 BC041485.2 BC125116.1 

    7 DOTS entries:

    DT.97809039  DT.70105200  DT.120913669  DT.91819761  DT.120913673  DT.99992053  DT.100737501 

    Selected AceView cDNA sequences (see all 46):

    BC041485 BU618480 CR590425 CA310959 NM_178509 CA848207 CA429281 BU686235 
    AA952876 AK122865 CR593155 AI095537 AI376134 D63113 BE856462 BX384500 
    AK123793 CD644143 BM969750 AI126515 AI700107 BM709250 CF993836 BX382851 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for STXBP4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
    SP1:                          -     -                             -                             -         
    SP2:                    -     -     -                             -                                       
    SP3:                          -                                                                           
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for STXBP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STXBP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCTGACA
    STXBP4 Expression
    About this image


    STXBP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    STXBP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STXBP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.35199
        Custom PCR Arrays for STXBP4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STXBP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for STXBP4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stxbp41 , 5 syntaxin binding protein 41, 5 82.19(n)1
    77.17(a)1
      11 (55.04 cM)5
    209131  NM_011505.21  NP_035635.11 
     904764925 
    chicken
    (Gallus gallus)
    Aves STXBP41 syntaxin binding protein 4 67.1(n)
    61.64(a)
      417393  XM_004946157.1  XP_004946214.1 
    lizard
    (Anolis carolinensis)
    Reptilia STXBP46
    syntaxin binding protein 4
    54(a)
    1 ↔ 1
    GL343242.1(1964040-2105857)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.74682 Transcribed sequence with weak similarity to protein more 75.97(n)    137712159 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5679161 syntaxin-binding protein 4-like 55.26(n)
    48.37(a)
      567916  XM_691230.6  XP_696322.6 


    ENSEMBL Gene Tree for STXBP4 (if available)
    TreeFam Gene Tree for STXBP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STXBP4 gene
    1 SIMAP similar gene for STXBP4 using alignment to 5 protein entries:     STXB4_HUMAN (see all proteins):
    DLG4

    Find genes that share paralogs with STXBP4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STXBP4 (see all 3491)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs800550061,2
    F--48403514(+) GAAAAG/ATAATT 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs678581541,2
    C--48421088(+) TTTTT-/C/CT  
            
    TTTTT
    1 -- int12NA 4
    rs1915789851,2
    --53048155(+) GACTCC/TAGTAT 1 -- int10--------
    rs1842935431,2
    --53048202(+) TATGTA/GCAGTG 1 -- int10--------
    rs1398450061,2
    C--53048263(+) AAAAGA/GAAATA 1 -- int10--------
    rs177453441,2
    C,F,H--53048319(+) TGTTTA/GTGAAA 1 -- int112Minor allele frequency- G:0.15NA NS EA 802
    rs98958081,2
    C,F--53048442(+) TATTTC/GTGCAA 1 -- int113Minor allele frequency- G:0.27NA WA EA 514
    rs98974471,2
    C,F--53048469(+) TTTCTT/CGTATA 1 -- int110Minor allele frequency- C:0.26NA WA EA 508
    rs98960441,2
    C,F,H--53048542(+) tatttC/Gctatt 1 -- int111Minor allele frequency- G:0.23NS EA NA WA 780
    rs1421897371,2
    C--53048551(+) TTACAA/GGAACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for STXBP4 (53046088 - 53241646 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for STXBP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2478056CNV Deletion19546169
    esv273017CNV Insertion20981092
    esv267853CNV Insertion20981092
    nsv515749CNV Loss19592680
    nsv457853CNV Loss19166990
    nsv522299CNV Loss19592680
    nsv908620CNV Loss21882294
    nsv833489CNV Gain17160897

    Human Gene Mutation Database (HGMD): STXBP4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STXBP4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610415    OMIM disorders: --


    Find genes that share disorders with STXBP4           About GenesLikeMe

    Genetic Association Database (GAD): STXBP4
    Human Genome Epidemiology (HuGE) Navigator: STXBP4 (7 documents)

    Export disorders for STXBP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STXBP4 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with STXBP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cell. (PubMed id 12855681)1, 3, 9 Saito T....Mori M. (J. Biol. Chem. 2003)
    2. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PubMed id 20095854)1, 4 Bhatti P....Sigurdson A.J. (Radiat. Res. 2010)
    3. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    4. Common genetic variants associated with breast cancer and mammographic density measures that predict disease. (PubMed id 20145138)1, 4 Odefrey F....Southey M.C. (Cancer Res. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes. (PubMed id 10394363)1, 9 Min J....Pessin J.E. (Mol. Cell 1999)
    8. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (Nat. Genet. 2013)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. Association of STXBP4/COX11 rs6504950 (G&gt;A) polymorphism with breast cancer risk: evidence from 17,960 cases and 22,713 controls. (PubMed id 22863968)1 Tang L....Guan X.X. (Arch. Med. Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 252983 HGNC: 19694 AceView: STXBP4 Ensembl:ENSG00000166263 euGenes: HUgn252983
    ECgene: STXBP4 H-InvDB: STXBP4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STXBP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STXBP4 gene:
    Search GeneIP for patents involving STXBP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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