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Aliases for STXBP3 Gene

Aliases for STXBP3 Gene

  • Syntaxin Binding Protein 3 2 3
  • Protein Unc-18 Homolog 3 3 4
  • Protein Unc-18 Homolog C 3 4
  • Platelet Sec1 Protein 3 4
  • UNC-18C 3 4
  • Unc18-3 3 4
  • PSP 3 4
  • Syntaxin 4 Binding Protein 3
  • Syntaxin-Binding Protein 3 3
  • MUNC18-3 3
  • MUNC18C 3

External Ids for STXBP3 Gene

Previous GeneCards Identifiers for STXBP3 Gene

  • GC01M109954
  • GC01P108266
  • GC01P108387
  • GC01P108635
  • GC01P109001
  • GC01P109094
  • GC01P109289
  • GC01P107182

Summaries for STXBP3 Gene

GeneCards Summary for STXBP3 Gene

STXBP3 (Syntaxin Binding Protein 3) is a Protein Coding gene. Among its related pathways are Hemostasis and Hemostasis. GO annotations related to this gene include syntaxin binding and syntaxin-1 binding. An important paralog of this gene is STXBP1.

UniProtKB/Swiss-Prot for STXBP3 Gene

  • Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.

Gene Wiki entry for STXBP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STXBP3 Gene

Genomics for STXBP3 Gene

Regulatory Elements for STXBP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STXBP3 Gene

108,746,663 bp from pter
108,809,526 bp from pter
62,864 bases
Plus strand

Genomic View for STXBP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STXBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STXBP3 Gene

Proteins for STXBP3 Gene

  • Protein details for STXBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Syntaxin-binding protein 3
    Protein Accession:
    Secondary Accessions:
    • A8K269
    • A8K5K7
    • Q53FW1
    • Q86YJ3
    • Q9UPD7

    Protein attributes for STXBP3 Gene

    592 amino acids
    Molecular mass:
    67764 Da
    Quaternary structure:
    • Interacts with DOC2B; the interaction is direct, occurs at the cell membrane, excludes interaction with STX4 and regulates glucose-stimulated insulin secretion (By similarity). Interacts with STX4.

neXtProt entry for STXBP3 Gene

Proteomics data for STXBP3 Gene at MOPED

Post-translational modifications for STXBP3 Gene

  • Phosphorylated by PKC in platelets in response to thrombin stimulation; phosphorylation inhibits binding to STX4.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STXBP3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for STXBP3 (Syntaxin-BP3)

No data available for DME Specific Peptides for STXBP3 Gene

Domains for STXBP3 Gene

Protein Domains for STXBP3 Gene


Suggested Antigen Peptide Sequences for STXBP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O00186
  • Belongs to the STXBP/unc-18/SEC1 family.
genes like me logo Genes that share domains with STXBP3: view

No data available for Gene Families for STXBP3 Gene

Function for STXBP3 Gene

Molecular function for STXBP3 Gene

UniProtKB/Swiss-Prot Function:
Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.

Gene Ontology (GO) - Molecular Function for STXBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12773094
GO:0017075 syntaxin-1 binding IEA --
GO:0019905 syntaxin binding IPI 12773094
genes like me logo Genes that share ontologies with STXBP3: view
genes like me logo Genes that share phenotypes with STXBP3: view

Animal Models for STXBP3 Gene

MGI Knock Outs for STXBP3:

Animal Model Products

CRISPR Products

miRNA for STXBP3 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for STXBP3 Gene

Localization for STXBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STXBP3 Gene

Cytoplasm, cytosol. Cell membrane. Note=In platelets, predominantly cytosolic. Low amounts membrane-associated.

Subcellular locations from

Jensen Localization Image for STXBP3 Gene COMPARTMENTS Subcellular localization image for STXBP3 gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for STXBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA 18588921
GO:0016323 basolateral plasma membrane IEA --
GO:0016324 apical plasma membrane IEA --
GO:0031091 platelet alpha granule IDA 12773094
genes like me logo Genes that share ontologies with STXBP3: view

Pathways for STXBP3 Gene

genes like me logo Genes that share pathways with STXBP3: view

Gene Ontology (GO) - Biological Process for STXBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis --
GO:0006904 vesicle docking involved in exocytosis IEA --
GO:0007420 brain development IEA --
GO:0007596 blood coagulation TAS --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with STXBP3: view

Compounds for STXBP3 Gene

(1) Novoseek inferred chemical compound relationships for STXBP3 Gene

Compound -log(P) Hits PubMed IDs
glucose 39.5 7
genes like me logo Genes that share compounds with STXBP3: view

Transcripts for STXBP3 Gene

Unigene Clusters for STXBP3 Gene

Syntaxin binding protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STXBP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STXBP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - -

Relevant External Links for STXBP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STXBP3 Gene

mRNA expression in normal human tissues for STXBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for STXBP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STXBP3 Gene

SOURCE GeneReport for Unigene cluster for STXBP3 Gene Hs.530436

mRNA Expression by UniProt/SwissProt for STXBP3 Gene

Tissue specificity: Megakaryocytes and platelets
genes like me logo Genes that share expressions with STXBP3: view

Expression partners for STXBP3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for STXBP3 Gene

Orthologs for STXBP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STXBP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STXBP3 35
  • 93.02 (n)
  • 94.09 (a)
  • 94 (a)
(Canis familiaris)
Mammalia STXBP3 35
  • 93.75 (n)
  • 94.76 (a)
  • 95 (a)
(Mus musculus)
Mammalia Stxbp3a 35
  • 87.93 (n)
  • 92.05 (a)
Stxbp3a 16
Stxbp3a 36
  • 91 (a)
Stxbp3b 36
  • 84 (a)
(Pan troglodytes)
Mammalia STXBP3 35
  • 99.66 (n)
  • 99.83 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Stxbp3 35
  • 87.39 (n)
  • 91.22 (a)
(Monodelphis domestica)
Mammalia STXBP3 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia STXBP3 36
  • 87 (a)
(Gallus gallus)
Aves STXBP3 35
  • 77.05 (n)
  • 76.98 (a)
  • 75 (a)
(Anolis carolinensis)
Reptilia STXBP3 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stxbp3 35
  • 69.35 (n)
  • 69.35 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16785 35
(Danio rerio)
Actinopterygii stxbp3 35
  • 61.21 (n)
  • 60.63 (a)
wufb71h06 35
stxbp3 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rop 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea T07A9.10 37
  • 30 (a)
unc-18 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC1 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for STXBP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STXBP3 Gene

Gene Tree for STXBP3 (if available)
Gene Tree for STXBP3 (if available)

Paralogs for STXBP3 Gene

Paralogs for STXBP3 Gene

Selected SIMAP similar genes for STXBP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STXBP3: view

Variants for STXBP3 Gene

Sequence variations from dbSNP and Humsavar for STXBP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs754756 -- 108,787,066(+) aaaat(G/T)tgatt intron-variant
rs872337 -- 108,750,030(-) TGGCT(A/G)TTGAG intron-variant
rs872338 -- 108,749,770(-) CCAGA(C/G)GAAAA intron-variant
rs872339 -- 108,749,712(-) AAGAA(A/C)GAACT intron-variant
rs994440 -- 108,791,983(+) attgc(C/T)gagta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STXBP3 Gene

Variant ID Type Subtype PubMed ID
esv1070190 CNV Deletion 17803354
nsv823908 CNV Loss 20364138
nsv2287 CNV Loss 18451855
esv29430 CNV Loss 19812545

Relevant External Links for STXBP3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STXBP3 Gene

Disorders for STXBP3 Gene

Relevant External Links for STXBP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for STXBP3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for STXBP3 Gene

Publications for STXBP3 Gene

  1. Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion. (PMID: 10194441) Reed G.L. … Fitzgerald M.L. (Blood 1999) 2 3 4 23
  2. Munc18-syntaxin complexes and exocytosis in human platelets. (PMID: 12649283) Houng A. … Reed G.L. (J. Biol. Chem. 2003) 3 23
  3. Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. (PMID: 15576373) Fu J. … Malik A.B. (J. Biol. Chem. 2005) 3 23
  4. Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. (PMID: 15707389) Hodgkinson C.P. … Sale G.J. (Biochem. J. 2005) 3 23
  5. Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils. (PMID: 18588921) Brochetta C. … Blank U. (Biochim. Biophys. Acta 2008) 3 23

Products for STXBP3 Gene

Sources for STXBP3 Gene

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