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STXBP3 Gene

protein-coding   GIFtS: 62
GCID: GC01P109289

Syntaxin Binding Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Syntaxin Binding Protein 31 2     UNC-18C2
Platelet Sec1 Protein2 3     Syntaxin 4 Binding Protein2
Protein Unc-18 Homolog 32 3     Syntaxin-Binding Protein 32
Protein Unc-18 Homolog C2 3     unc18-32
PSP2 3     Unc-18C3
MUNC18-32     Unc18-33
MUNC18C2     

External Ids:    HGNC: 114461   Entrez Gene: 68142   Ensembl: ENSG000001162667   OMIM: 6083395   UniProtKB: O001863   

Export aliases for STXBP3 gene to outside databases

Previous GC identifers: GC01M109954 GC01P108266 GC01P108387 GC01P108635 GC01P109001 GC01P109094 GC01P107182


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STXBP3 Gene:
STXBP3 (syntaxin binding protein 3) is a protein-coding gene. Diseases associated with STXBP3 include alcoholic pancreatitis, and polycystic ovary syndrome. GO annotations related to this gene include syntaxin binding and syntaxin-1 binding. An important paralog of this gene is STXBP1.

UniProtKB/Swiss-Prot: STXB3_HUMAN, O00186
Function: Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in
docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity)

Gene Wiki entry for STXBP3 (Syntaxin binding protein 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the STXBP3 gene promoter:
         Sp1   ATF-2   LUN-1   RORalpha2   Meis-1b   CRE-BP1   POU2F1   POU2F1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTXBP3 promoter sequence
   Search Chromatin IP Primers for STXBP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STXBP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

STXBP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STXBP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P109289:  view genomic region     (about GC identifiers)

Start:
109,289,285 bp from pter      End:
109,352,148 bp from pter
Size:
62,864 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: STXB3_HUMAN, O00186 (See protein sequence)
Recommended Name: Syntaxin-binding protein 3  
Size: 592 amino acids; 67764 Da
Subunit: Interacts with DOC2B; the interaction is direct, occurs at the cell membrane, excludes interaction with
STX4 and regulates glucose-stimulated insulin secretion (By similarity). Interacts with STX4
Secondary accessions: A8K269 A8K5K7 Q53FW1 Q86YJ3 Q9UPD7

Explore the universe of human proteins at neXtProt for STXBP3: NX_O00186

Explore proteomics data for STXBP3 at MOPED

Post-translational modifications: 

  • Phosphorylated by PKC in platelets in response to thrombin stimulation; phosphorylation inhibits binding to STX41
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STXBP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009200.2  
    ENSEMBL proteins: 
     ENSP00000359025  
    Reactome Protein details: O00186

    STXBP3 Human Recombinant Protein Products:

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    STXBP3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001619 Sec1-like
     IPR027482 Sec-1-like_dom2

    Graphical View of Domain Structure for InterPro Entry O00186

    ProtoNet protein and cluster: O00186

    1 Blocks protein domain: IPB001619 Sec1-like protein

    UniProtKB/Swiss-Prot: STXB3_HUMAN, O00186
    Similarity: Belongs to the STXBP/unc-18/SEC1 family


    STXBP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STXB3_HUMAN, O00186
    Function: Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in
    docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12773094
    GO:0017075syntaxin-1 binding IEA--
    GO:0019905syntaxin binding IPI12773094
         
    STXBP3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for STXBP3:
     Lamellipodia cells 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Stxbp3a):
     embryogenesis  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  mortality/aging 
     nervous system 

    STXBP3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for STXBP3: Stxbp3atm1Jepn Stxbp3atm1Yt

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STXBP3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STXBP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STXBP3

    miRNA
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    miRTarBase miRNAs that target STXBP3:
    hsa-mir-1 (MIRT023896), hsa-mir-16-5p (MIRT031842), hsa-mir-26b-5p (MIRT029784), hsa-mir-378a-3p (MIRT043953)

    Block miRNA regulation of human, mouse, rat STXBP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STXBP3 (see all 13):
    hsa-miR-576-5p hsa-miR-15a hsa-miR-487a hsa-miR-485-3p hsa-miR-497 hsa-miR-154* hsa-miR-582-5p hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidSTXBP3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STXBP3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: STXBP3 (NM_007269)
    Sino Biological Human cDNA Clone for STXBP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STXBP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STXBP3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STXBP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STXB3_HUMAN, O00186: Cytoplasm, cytosol. Cell membrane. Note=In platelets, predominantly cytosolic. Low amounts
    membrane-associated
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane5
    nucleus4
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA18588921
    GO:0016323basolateral plasma membrane IEA--

    STXBP3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STXBP3 About    
    See pathways by source

    SuperPathContained pathways About
    1Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Disinhibition of SNARE formation0.00
    2Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    3Clathrin derived vesicle budding
    Membrane Trafficking0.32
    Translocation of GLUT4 to the Plasma Membrane0.32
    4Insulin Signaling
    Insulin Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for STXBP3
        Insulin Signaling


    2 Reactome Pathways for STXBP3
        Disinhibition of SNARE formation
    Translocation of GLUT4 to the plasma membrane



    STXBP3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STXBP3
    Interactions:

        GeneGlobe Interaction Network for STXBP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STXBP3 (O001863 ENSP000003590254) via UniProtKB, MINT, STRING, and/or I2D (see all 112)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN2Q166373, ENSP000003701194I2D: score=1 STRING: ENSP00000370119
    STX4Q128463, ENSP000003177144I2D: score=3 STRING: ENSP00000317714
    GEMIN4P576783, ENSP000003217064I2D: score=2 STRING: ENSP00000321706
    SNRPD2P623163, ENSP000003423744I2D: score=2 STRING: ENSP00000342374
    SMN1Q166373I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006904vesicle docking involved in exocytosis IEA--
    GO:0007596blood coagulation TAS--
    GO:0015031protein transport IEA--
    GO:0016192vesicle-mediated transport ----
    GO:0030168platelet activation TAS--

    STXBP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STXBP3 (STXB3)

    1 Novoseek inferred chemical compound relationship for STXBP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 39.5 10 18652694 (2), 20053958 (1), 15707389 (1), 17916632 (1) (see all 6)



    STXBP3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STXBP3 gene: 
    NM_007269.2  

    Unigene Cluster for STXBP3:

    Syntaxin binding protein 3
    Hs.530436  [show with all ESTs]
    Unigene Representative Sequence: NM_007269
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483586 ENST00000469338 ENST00000370008(uc021oqz.1 uc001dvy.3)
    ENST00000486601 ENST00000485167 ENST00000495245 ENST00000472099
    miRNA
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    Block miRNA regulation of human, mouse, rat STXBP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STXBP3 (see all 13):
    hsa-miR-576-5p hsa-miR-15a hsa-miR-487a hsa-miR-485-3p hsa-miR-497 hsa-miR-154* hsa-miR-582-5p hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidSTXBP3 3' UTR sequence
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STXBP3
      QuantiTect SYBR Green Assays in human, mouse, rat STXBP3
      QuantiFast Probe-based Assays in human, mouse, rat STXBP3

    Additional mRNA sequence: 

    AF032922.1 AK223170.1 AK290134.1 AK291322.1 AK312910.1 BC028028.1 BC038099.2 BC047764.1 
    D63506.1 

    11 DOTS entries:

    DT.414101  DT.99932311  DT.121397657  DT.91715224  DT.100872044  DT.91766470  DT.97814853  DT.100037108 
    DT.100037110  DT.91733503  DT.91757682 

    Selected AceView cDNA sequences (see all 188):

    AW627572 BP353384 BQ447225 BE048958 AI356988 AW965096 AV720484 AL603036 
    AV660735 BM835308 AW630812 AV660665 AW517672 CR606910 CB143974 AV720485 
    AI669581 AI383990 AI598106 AI635695 AV694866 BM126654 CR610191 BU631014 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for STXBP3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                -                             -                                                               
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for STXBP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STXBP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACATTCTAA
    STXBP3 Expression
    About this image


    STXBP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    STXBP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STXBP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530436

    UniProtKB/Swiss-Prot: STXB3_HUMAN, O00186
    Tissue specificity: Megakaryocytes and platelets

        Custom PCR Arrays for STXBP3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STXBP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for STXBP3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stxbp3a1 , 5 syntaxin binding protein 3A1, 5 87.93(n)1
    92.05(a)1
      3 (47.73 cM)5
    209121  NM_011504.11  NP_035634.11 
     1087931765 
    chicken
    (Gallus gallus)
    Aves STXBP31 syntaxin binding protein 3 77.05(n)
    76.98(a)
      424341  NM_001079734.2  NP_001073202.1 
    lizard
    (Anolis carolinensis)
    Reptilia STXBP36
    syntaxin binding protein 3
    75(a)
    1 ↔ 1
    GL343211.1(2167690-2216772)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.167852 Xenopus laevis transcribed sequence with weak similarity more 75.08(n)    AW633599.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb71h062 Danio rerio cDNA clone MGC63761 IMAGE2641033, complete more 70.65(n)    BC058874.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rop6
    Ras opposite
    43(a)
    1 → many
    3L(4136359-4138996)
    worm
    (Caenorhabditis elegans)
    Secernentea T07A9.103 acetylcholine regulator 30(a)   IV(390606-393038)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC16
    Sm-like protein involved in docking and fusion of ...
    19(a)
    1 → many
    IV(782041-784215) YDR164C


    ENSEMBL Gene Tree for STXBP3 (if available)
    TreeFam Gene Tree for STXBP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STXBP3 gene
    STXBP12  STXBP22  
    3 SIMAP similar genes for STXBP3 using alignment to 1 protein entry:     STXB3_HUMAN:
    STXBP1    stxbp1    STXBP2

    STXBP3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STXBP3 (see all 1366)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113613541,2
    C--109287926(+) ATTAA-/T/TT  
            
    TTTTT
    1 -- us2k1 tfbs3 trp31CSA 2
    rs575462401,2
    C--109287940(+) TTTTT-/TTGGTGG 1 -- us2k12Minor allele frequency- TT:0.25NA 4
    rs1164414901,2
    C,F--109288056(+) CCATGC/ACCAGC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1505635801,2
    --109288124(+) ACTACC/TCTATT 1 -- us2k10--------
    rs1877049271,2
    --109288327(+) TAGTAA/GTAGTA 1 -- us2k10--------
    rs1928641241,2
    --109288730(+) CTACCG/TGCAGC 1 -- us2k10--------
    rs1832037261,2
    --109288764(+) TTAGAC/TTGTAA 1 -- us2k10--------
    rs17594871,2
    C,F,A,H--109288766(+) AGATTA/GTAAAT 1 -- us2k1 tfbs327Minor allele frequency- G:0.45MN EA NS NA WA CSA 2888
    rs1874886101,2
    --109288864(+) TTCTAC/TGCAAT 1 -- us2k10--------
    rs741125131,2
    C,F--109288950(+) ACTGAG/ATGAAG 1 -- us2k13Minor allele frequency- A:0.06WA NA 240

    HapMap Linkage Disequilibrium report for STXBP3 (109289285 - 109352148 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for STXBP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1070190CNV Deletion17803354
    nsv2287CNV Loss18451855
    esv29430CNV Loss19812545
    nsv823908CNV Loss20364138

    Human Gene Mutation Database (HGMD): STXBP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STXBP3
    DNA2.0 Custom Variant and Variant Library Synthesis for STXBP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608339    OMIM disorders: --

    7 diseases for STXBP3:    
    About MalaCards
    alcoholic pancreatitis    polycystic ovary syndrome    insulin resistance    obesity
    pancreatitis    endotheliitis    neuronitis


    STXBP3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): STXBP3
    Human Genome Epidemiology (HuGE) Navigator: STXBP3 (1 document)

    Export disorders for STXBP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STXBP3 gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with STXBP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion. (PubMed id 10194441)1, 2, 3, 9 Reed G.L.... Fitzgerald M.L. (Blood 1999)
    2. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants. (PubMed id 8824310)1, 2 Gengyo-Ando K.... Ikawa Y. (J. Neurosci. 1996)
    5. Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils. (PubMed id 18588921)1, 9 Brochetta C....Blank U. (Biochim. Biophys. Acta 2008)
    6. Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. (PubMed id 15576373)1, 9 Fu J....Malik A.B. (J. Biol. Chem. 2005)
    7. Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. (PubMed id 15707389)1, 9 Hodgkinson C.P....Sale G.J. (Biochem. J. 2005)
    8. Munc18-syntaxin complexes and exocytosis in human platelets. (PubMed id 12649283)1, 9 Houng A....Reed G.L. (J. Biol. Chem. 2003)
    9. Munc18c in adipose tissue is downregulated in obesity and is associated with insulin. (PubMed id 23700440)1 Garrido-Sanchez L....Tinahones F.J. (PLoS ONE 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 6814 HGNC: 11446 AceView: STXBP3 Ensembl:ENSG00000116266 euGenes: HUgn6814
    ECgene: STXBP3 H-InvDB: STXBP3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STXBP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for STXBP3 gene:
    Search GeneIP for patents involving STXBP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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