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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STXBP3 Gene

protein-coding   GIFtS: 57
GCID: GC01P109289

syntaxin binding protein 3
 Explore 8 diseases affiliated with
STXBP3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STXBP3    

Aliases
for STXBP3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Syntaxin Binding Protein 31 2     MUNC18C2
UNC-18C1 2     Syntaxin 4 Binding Protein2
Platelet Sec1 Protein2 3     Syntaxin-Binding Protein 32
Protein Unc-18 Homolog 32 3     Unc18-33
Protein Unc-18 Homolog C2 3     Unc-18C3
PSP2 3     Unc18-33
MUNC18-32     

External Ids:    HGNC: 114461   Entrez Gene: 68142   Ensembl: ENSG000001162667   OMIM: 6083395   UniProtKB: O001863   

Export aliases for STXBP3 gene to outside databases

Previous GC identifers: GC01M109954 GC01P108266 GC01P108387 GC01P108635 GC01P109001 GC01P109094 GC01P107182


Summaries
for STXBP3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: STXB3_HUMAN, O00186
Function: Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of
intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity)

Gene Wiki entry for STXBP3 (Syntaxin binding protein 3)


Genomic Views
for STXBP3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STXBP3 gene promoter:
         Sp1   ATF-2   LUN-1   RORalpha2   Meis-1b   CRE-BP1   POU2F1   POU2F1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STXBP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for STXBP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STXBP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

STXBP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STXBP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P109289:  view genomic region     (about GC identifiers)

Start:
 109,289,285 bp from pter      End:
 109,352,148 bp from pter
Size:
 62,864 bases      Orientation:
 plus strand

Proteins
for STXBP3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STXB3_HUMAN, O00186 (See protein sequence)
Recommended Name: Syntaxin-binding protein 3  
Size: 592 amino acids; 67764 Da
Subunit: Interacts with DOC2B; the interaction is direct, occurs at the cell membrane, excludes interaction with STX4
and regulates glucose-stimulated insulin secretion (By similarity). Interacts with STX4
Subcellular location: Cytoplasm, cytosol. Cell membrane. Note=In platelets, predominantly cytosolic. Low amounts
membrane-associated
Secondary accessions: A8K269 A8K5K7 Q53FW1 Q86YJ3 Q9UPD7

Explore the universe of human proteins at neXtProt for STXBP3: NX_O00186

Post-translational modifications:

  • Phosphorylated by PKC in platelets in response to thrombin stimulation; phosphorylation inhibits binding to STX41
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00186

    • STXBP3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_009200.2  
    ENSEMBL proteins: 
     ENSP00000359025  
    Reactome Protein details: O00186
    Human Recombinant Protein Products: 
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    Novus Biologicals STXBP3 Proteins
    Novus Biologicals STXBP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for STXBP3

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA18588921


    STXBP3 for ontologies           About GeneDecksing



    STXBP3 Antibody Products: 
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    Uscn ELISAs and CLIAs for STXBP3

    Protein Domains /
    Families
    for STXBP3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STXBP3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001619 Sec1-like

    Graphical View of Domain Structure for InterPro Entry O00186

    ProtoNet protein and cluster: O00186

    1 Blocks protein family: IPB001619 Sec1-like protein

    UniProtKB/Swiss-Prot: STXB3_HUMAN, O00186
    Similarity: Belongs to the STXBP/unc-18/SEC1 family


    Function
    for STXBP3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STXB3_HUMAN, O00186
    Function: Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of
    intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: STXBP3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STXBP3
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate STXBP3 (see all 13):
    hsa-miR-576-5p hsa-miR-15a hsa-miR-487a hsa-miR-485-3p hsa-miR-497 hsa-miR-154* hsa-miR-582-5p hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: STXBP3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STXBP3 (see all 4)
    OriGene shRNA RFP: STXBP3
    OriGene siRNA: STXBP3
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STXBP3 

    Cell Line
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    Search LifeMap BioReagents cell lines for STXBP3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STXBP3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12773094
    GO:0017075syntaxin-1 binding IEA--
    GO:0019905syntaxin binding IPI15576373


    STXBP3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for STXBP3:
     Lamellipodia cells 

    Animal Models:
         Mouse knock-outs for STXBP3: Stxbp3atm1Dct Stxbp3atm1Yt
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Stxbp3a):
     embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism  mortality/aging 
     nervous system 

    STXBP3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for STXBP3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Membrane Trafficking
    		Membrane Trafficking1.00
    		Translocation of GLUT4 to the Plasma Membrane0.32
    2Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43
    3Fusion of GLUT4 Vesicle with the Plasma Membrane
    		Fusion of GLUT4 Vesicle with the Plasma Membrane1.00
    4Disinhibition of SNARE formation
    		Disinhibition of SNARE formation1.00
    5Insulin Signaling
    		Insulin Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for STXBP3 
        Insulin Signaling

    5/7        Reactome Pathways for STXBP3 (see all 7)
        Hemostasis
    Membrane Trafficking
    Disinhibition of SNARE formation
    Translocation of GLUT4 to the Plasma Membrane
    Platelet activation, signaling and aggregation



    STXBP3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STXBP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for STXBP3 (O001863 ENSP000003590254) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN2Q166373, ENSP000003701194I2D: score=1 STRING: ENSP00000370119
    STX4Q128463, ENSP000003177144I2D: score=3 STRING: ENSP00000317714
    GEMIN4P576783, ENSP000003217064I2D: score=2 STRING: ENSP00000321706
    SNRPD2P623163, ENSP000003423744I2D: score=2 STRING: ENSP00000342374
    SMN1Q166373I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006904vesicle docking involved in exocytosis IEA--
    GO:0007596blood coagulation TAS--
    GO:0015031protein transport IEA--
    GO:0030168platelet activation TAS--
    GO:0043312neutrophil degranulation IEP18588921


    STXBP3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for STXBP3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STXBP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STXBP3
    1 Novoseek chemical compound relationship for STXBP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 39.5 10 18652694 (2), 20053958 (1), 15707389 (1), 17916632 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about STXBP3 / STXB3 

    Transcripts
    for STXBP3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STXBP3 gene: 
    NM_007269.2  

    Unigene Cluster for STXBP3:

    Syntaxin binding protein 3
    Hs.530436  [show with all ESTs]
    Unigene Representative Sequence: NM_007269
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483586 ENST00000469338 ENST00000370008(uc021oqz.1 uc001dvy.3)
    ENST00000486601 ENST00000485167 ENST00000495245 ENST00000472099

    miRNA
    Products:             		 OriGene 3'-UTR Clone: STXBP3
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STXBP3
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate STXBP3 (see all 13):
    hsa-miR-576-5p hsa-miR-15a hsa-miR-487a hsa-miR-485-3p hsa-miR-497 hsa-miR-154* hsa-miR-582-5p hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: STXBP3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STXBP3 (see all 4)
    OriGene shRNA RFP: STXBP3
    OriGene siRNA: STXBP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STXBP3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STXBP3 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STXBP3
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    GenScript: all cDNA clones in your preferred vector: STXBP3 (NM_007269)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STXBP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STXBP3

    Additional cDNA sequence: 

    AF032922.1 AK223170.1 AK290134.1 AK291322.1 AK312910.1 BC028028.1 BC038099.2 BC047764.1 
    D63506.1 

    11 DOTS entries:

    DT.414101  DT.99932311  DT.121397657  DT.91715224  DT.100872044  DT.91766470  DT.97814853  DT.100037108 
    DT.100037110  DT.91733503  DT.91757682 

    24/188 AceView cDNA sequences (see all 188):

    AI598106 AV660735 AI669581 BM835308 AW627572 R61856 AI635695 AV661506 
    BE464825 BG576612 AV694866 BQ447225 CB143974 AV720484 BI335856 AA669965 
    BG387574 AW965096 BP353384 AW769244 AI383990 BU631014 BM126654 AW517672 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for STXBP3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                -                             -                                                               
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for STXBP3

    Expression
    for STXBP3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STXBP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACATTCTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See STXBP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STXBP3

    SOURCE GeneReport for Unigene cluster: Hs.530436

    UniProtKB/Swiss-Prot: STXB3_HUMAN, O00186
    Tissue specificity: Megakaryocytes and platelets

        SABiosciences Custom PCR Arrays for STXBP3
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STXBP3

    Orthologs
    for STXBP3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STXBP3 gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves STXBP31 syntaxin binding protein 3 77.05(n)
    76.98(a)    		   424341  NM_001079734.1  NP_001073202.1 
    lizard
    (Anolis carolinensis)    		 Reptilia STXBP36
    		 --
    		 74(a)
    		 1 ↔ 1
    		 GL343211.1(2171587-2203004)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.167852 Xenopus laevis transcribed sequence with weak similarity more 75.08(n)    AW633599.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb71h062 Danio rerio cDNA clone MGC63761 IMAGE2641033, complete more 70.65(n)    BC058874.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rop6
    		 Ras opposite
    		 43(a)
    		 1 → many
    		 3L(4136359-4138996)
    worm
    (Caenorhabditis elegans)    		 Secernentea T07A9.103 acetylcholine regulator 30(a)   IV(390606-393038)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SEC1B6
    KEU6
    (see all 3)    		 SNARE-interacting protein KEULE
    (see all 3)    		 22(a)
    21(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 4(7256538-7261180)
    1(4200876-4206404)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 Sec1 family transport protein, putative, expressed...
    Sec1 family transport protein, putative, expressed...
    (see all 3)    		 22(a)
    21(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 6(1899863-1908009)
    2(14936663-14956221)


    ENSEMBL Gene Tree for STXBP3 (if available)
    TreeFam Gene Tree for STXBP3 (if available) 

    Paralogs
    for STXBP3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STXBP3 gene
    STXBP12  STXBP22  
    3 SIMAP similar genes for STXBP3 using alignment to 1 protein entry:     STXB3_HUMAN:
    STXBP1    stxbp1    STXBP2

    STXBP3 for paralogs           About GeneDecksing



    Genomic Variants
    for STXBP3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1142 NCBI SNPs in STXBP3 are shown (see all 1142)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs575462401,2
    		C--109287926(+) TTTTT-/TTGGTGG 1 -- us2k12Minor allele frequency- TT:0.25NA 4
    rs1164414901,2
    		F,--109288056(+) CCATGC/ACCAGC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1505635801,2
    		--109288124(+) ACTACC/TCTATT 1 -- us2k10--------
    rs1877049271,2
    		--109288327(+) TAGTAA/GTAGTA 1 -- us2k10--------
    rs1928641241,2
    		--109288730(+) CTACCG/TGCAGC 1 -- us2k10--------
    rs1832037261,2
    		--109288764(+) TTAGAC/TTGTAA 1 -- us2k10--------
    rs17594871,2
    		C,F,A,H,--109288766(+) AGATTA/GTAAAT 1 -- us2k1 tfbs327Minor allele frequency- G:0.45MN EA NS NA WA CSA 2888
    rs1874886101,2
    		--109288864(+) TTCTAC/TGCAAT 1 -- us2k10--------
    rs741125131,2
    		C,--109288950(+) ACTGAG/ATGAAG 1 -- us2k13Minor allele frequency- A:0.06WA NA 240
    rs1921887941,2
    		--109288975(+) CCTTGA/CGAAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for STXBP3 (109289285 - 109352148 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for STXBP3
         2 CNVs: 64548 34675
    Human Gene Mutation Database (HGMD): STXBP3

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    Disorders / Diseases
    for STXBP3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STXBP3 for disorders           About GeneDecksing

    OMIM gene information: 608339    OMIM disorders: --

    8 diseases for STXBP3:    About MalaCards
    insulin resistance    alcoholic pancreatitis    alcoholism    pancreatitis
    obesity    cholesterol    malaria    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: STXBP3 (1 document)

    Export disorders for STXBP3 gene to outside databases

    Publications
    for STXBP3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STXBP3 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with STXBP3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion. (PubMed id 10194441)1, 2, 3, 9 Reed G.L.... Fitzgerald M.L. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants. (PubMed id 8824310)1, 2 Gengyo-Ando K.... Ikawa Y. (1996)
    4. Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils. (PubMed id 18588921)1, 9 Brochetta C....Blank U. (2008)
    5. Protease-activated receptor-1 activation of endotheli al cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. (PubMed id 15576373)1, 9 Fu J....Malik A.B. (2005)
    6. Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. (PubMed id 15707389)1, 9 Hodgkinson C.P....Sale G.J. (2005)
    7. Munc18-syntaxin complexes and exocytosis in human platelets. (PubMed id 12649283)1, 9 Houng A....Reed G.L. (2003)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Protein expression of PKCZ (Protein Kinase C Zeta), Mu nc18c, and Syntaxin-4 in the insulin pathway in endometria of patients with poly cystic ovary syndrome (PCOS). (PubMed id 22390153)1 Rivero R....Vega M. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for STXBP3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing STXBP3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6814 HGNC: 11446 AceView: STXBP3 Ensembl:ENSG00000116266 euGenes: HUgn6814
    ECgene: STXBP3 H-InvDB: STXBP3

    Other Databases showing STXBP3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STXBP3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STXBP3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for STXBP3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STXBP3 gene:
    Search GeneIP for patents involving STXBP3

    GeneCards and IP:
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