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Aliases for STX8 Gene

Aliases for STX8 Gene

  • Syntaxin 8 2 3 5
  • CIP-1-Associated Regulator Of Cyclin B 3
  • CARB 3

External Ids for STX8 Gene

Previous GeneCards Identifiers for STX8 Gene

  • GC17M009501
  • GC17M010245
  • GC17M009096
  • GC17M009354
  • GC17M009094
  • GC17M009153

Summaries for STX8 Gene

Entrez Gene Summary for STX8 Gene

  • The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for STX8 Gene

STX8 (Syntaxin 8) is a Protein Coding gene. Among its related pathways are Normal wtCFTR traffic / ER-to-Golgi and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. GO annotations related to this gene include ubiquitin protein ligase binding and SNAP receptor activity.

UniProtKB/Swiss-Prot for STX8 Gene

  • Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

Gene Wiki entry for STX8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX8 Gene

Genomics for STX8 Gene

Regulatory Elements for STX8 Gene

Promoters for STX8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STX8 on UCSC Golden Path with GeneCards custom track

Genomic Location for STX8 Gene

Chromosome:
17
Start:
9,250,471 bp from pter
End:
9,576,591 bp from pter
Size:
326,121 bases
Orientation:
Minus strand

Genomic View for STX8 Gene

Genes around STX8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX8 Gene

Proteins for STX8 Gene

  • Protein details for STX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNK0-STX8_HUMAN
    Recommended name:
    Syntaxin-8
    Protein Accession:
    Q9UNK0
    Secondary Accessions:
    • O60712
    • Q53XT8

    Protein attributes for STX8 Gene

    Size:
    236 amino acids
    Molecular mass:
    26907 Da
    Quaternary structure:
    • Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8 (By similarity). Interacts with HECTD3 (By similarity).

neXtProt entry for STX8 Gene

Proteomics data for STX8 Gene at MOPED

Post-translational modifications for STX8 Gene

Other Protein References for STX8 Gene

Antibody Products

No data available for DME Specific Peptides for STX8 Gene

Domains & Families for STX8 Gene

Gene Families for STX8 Gene

Protein Domains for STX8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STX8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UNK0

UniProtKB/Swiss-Prot:

STX8_HUMAN :
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX8: view

Function for STX8 Gene

Molecular function for STX8 Gene

GENATLAS Biochemistry:
syntaxin 8,forming a synaptic core complex with synaptosome associated proteins,binding to N-type Ca2+ channels,involved in the intracellular membrane transport and exocytosis,soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein
UniProtKB/Swiss-Prot Function:
Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

Gene Ontology (GO) - Molecular Function for STX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IEA --
genes like me logo Genes that share ontologies with STX8: view
genes like me logo Genes that share phenotypes with STX8: view

Animal Models for STX8 Gene

MGI Knock Outs for STX8:
  • Stx8 tm2a(EUCOMM)Wtsi

Animal Model Products

miRNA for STX8 Gene

miRTarBase miRNAs that target STX8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STX8 Gene

Localization for STX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX8 Gene

Membrane; Single-pass type IV membrane protein. Note=Preferentially associated with the early endosome. To lesser extends, also present in late endosome, the plasma membrane and coated pits (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX8 Gene COMPARTMENTS Subcellular localization image for STX8 gene
Compartment Confidence
endosome 5
golgi apparatus 5
plasma membrane 5
cytosol 4
endoplasmic reticulum 4
lysosome 3
vacuole 3
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for STX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IEA --
GO:0005769 early endosome IDA 10564279
GO:0005770 late endosome IDA 10564279
GO:0005783 endoplasmic reticulum TAS 9852078
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STX8: view

Pathways & Interactions for STX8 Gene

genes like me logo Genes that share pathways with STX8: view

Gene Ontology (GO) - Biological Process for STX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 10198254
GO:0006886 intracellular protein transport IBA --
GO:0006906 vesicle fusion IEA,IBA --
GO:0008333 endosome to lysosome transport IEA --
genes like me logo Genes that share ontologies with STX8: view

No data available for SIGNOR curated interactions for STX8 Gene

Drugs & Compounds for STX8 Gene

(3) Additional Compounds for STX8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STX8: view

Transcripts for STX8 Gene

Unigene Clusters for STX8 Gene

Syntaxin 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STX8 Gene

No ASD Table

Relevant External Links for STX8 Gene

GeneLoc Exon Structure for
STX8
ECgene alternative splicing isoforms for
STX8

Expression for STX8 Gene

mRNA expression in normal human tissues for STX8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STX8 Gene

This gene is overexpressed in Liver (19.5), Peripheral blood mononuclear cells (17.3), and Pancreas (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX8 Gene



SOURCE GeneReport for Unigene cluster for STX8 Gene Hs.431109

mRNA Expression by UniProt/SwissProt for STX8 Gene

Q9UNK0-STX8_HUMAN
Tissue specificity: Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.
genes like me logo Genes that share expression patterns with STX8: view

Protein tissue co-expression partners for STX8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for STX8 Gene

Orthologs for STX8 Gene

This gene was present in the common ancestor of animals.

Orthologs for STX8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STX8 36
  • 100 (a)
OneToOne
STX8 35
  • 99.86 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia STX8 35
  • 92.2 (n)
  • 94.47 (a)
STX8 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STX8 36
  • 90 (a)
OneToOne
STX8 35
  • 87.46 (n)
  • 88.07 (a)
mouse
(Mus musculus)
Mammalia Stx8 36
  • 93 (a)
OneToOne
Stx8 16
Stx8 35
  • 88.84 (n)
  • 92.8 (a)
oppossum
(Monodelphis domestica)
Mammalia STX8 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX8 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stx8 35
  • 88.56 (n)
  • 92.8 (a)
chicken
(Gallus gallus)
Aves STX8 35
  • 70.5 (n)
  • 75.74 (a)
STX8 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX8 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17307 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2166 35
stx8 35
  • 65.96 (n)
  • 67.37 (a)
zebrafish
(Danio rerio)
Actinopterygii stx8 35
  • 62.54 (n)
  • 57.34 (a)
zgc64079 35
stx8 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006100 35
  • 43.27 (n)
  • 28.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syx8 35
  • 39.71 (n)
  • 24.4 (a)
Syx8 36
  • 25 (a)
OneToOne
Species with no ortholog for STX8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STX8 Gene

ENSEMBL:
Gene Tree for STX8 (if available)
TreeFam:
Gene Tree for STX8 (if available)

Paralogs for STX8 Gene

Pseudogenes.org Pseudogenes for STX8 Gene

genes like me logo Genes that share paralogs with STX8: view

No data available for Paralogs for STX8 Gene

Variants for STX8 Gene

Sequence variations from dbSNP and Humsavar for STX8 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs879686 -- 9,337,370(-) GATGG(C/G)AGAGG intron-variant
rs879687 -- 9,337,317(-) CTCAT(C/T)CTCTA intron-variant
rs879688 -- 9,337,250(-) TTTTT(C/T)TTCCA intron-variant
rs898008 -- 9,507,172(-) TGCCC(A/G)ACTGT intron-variant
rs898009 -- 9,464,235(+) AGAAA(C/G)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STX8 Gene

Variant ID Type Subtype PubMed ID
nsv7289 OTHER Inversion 18451855
nsv519249 CNV Loss 19592680
esv2661306 CNV Deletion 23128226
esv27693 CNV Loss 19812545
nsv833356 CNV Gain 17160897
nsv528816 CNV Loss 19592680
nsv521947 CNV Gain 19592680
esv2661151 CNV Deletion 23128226
dgv175n21 CNV Loss 19592680
esv29975 CNV Loss 17803354
nsv509652 CNV Insertion 20534489
esv2715631 CNV Deletion 23290073
esv29207 CNV Gain 19812545
esv33701 CNV Loss 17666407
nsv153 CNV Insertion 15895083
nsv1972 CNV Insertion 18451855
nsv436063 CNV Insertion 17901297
nsv111672 CNV Loss 16902084
nsv524312 CNV Loss 19592680
nsv907672 CNV Loss 21882294
esv2533392 CNV Insertion 19546169
esv2715632 CNV Deletion 23290073
esv2663291 CNV Deletion 23128226
nsv1973 CNV Insertion 18451855
nsv528692 CNV Gain 19592680
nsv833357 CNV Loss 17160897
nsv1974 CNV Insertion 18451855

Variation tolerance for STX8 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STX8 Gene

HapMap Linkage Disequilibrium report
STX8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX8 Gene

Disorders for STX8 Gene

Relevant External Links for STX8

Genetic Association Database (GAD)
STX8
Human Genome Epidemiology (HuGE) Navigator
STX8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STX8

No disorders were found for STX8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX8 Gene

Publications for STX8 Gene

  1. Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8). (PMID: 10198254) Thoreau V. … Chomel J.-C. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23 67
  2. Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8. (PMID: 18980942) He Y. … Linder M.E. (J. Lipid Res. 2009) 3 23
  3. Syntaxin 8 has two functionally distinct di-leucine-based motifs. (PMID: 17965969) Kasai K. … Akagawa K. (Cell. Mol. Biol. Lett. 2008) 3 23
  4. Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells. (PMID: 18570918) Bilan F. … Thoreau V. (Exp. Cell Res. 2008) 3 23
  5. Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease. (PMID: 14991845) Zhu X. … Smith M.A. (J. Neurosci. Res. 2004) 3 23

Products for STX8 Gene

Sources for STX8 Gene

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