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STX8 Gene

protein-coding   GIFtS: 60
GCID: GC17M009153

Syntaxin 8

  See STX8-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Syntaxin 81 2
CARB2
CIP-1-Associated Regulator Of Cyclin B2
syntaxin-82

External Ids:    HGNC: 114431   Entrez Gene: 94822   Ensembl: ENSG000001703107   OMIM: 6042035   UniProtKB: Q9UNK03   
ORGUL members:         

Export aliases for STX8 gene to outside databases

Previous GC identifers: GC17M009501 GC17M010245 GC17M009096 GC17M009354 GC17M009094


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STX8 Gene:
The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to
late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, May 2010)

GeneCards Summary for STX8 Gene:
STX8 (syntaxin 8) is a protein-coding gene. Diseases associated with STX8 include visual epilepsy. GO annotations related to this gene include SNAP receptor activity and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot: STX8_HUMAN, Q9UNK0
Function: Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating
retrograde transport from cis-Golgi membranes to the ER

Gene Wiki entry for STX8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the STX8 gene promoter:
         AML1a   MEF-2   MyoD   HNF-4alpha1   MEF-2A   Nkx6-1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTX8 promoter sequence
   Search Chromatin IP Primers for STX8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STX8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

STX8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STX8 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M009153:  view genomic region     (about GC identifiers)

Start:
9,153,788 bp from pter      End:
9,479,908 bp from pter
Size:
326,121 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STX8_HUMAN, Q9UNK0 (See protein sequence)
Recommended Name: Syntaxin-8  
Size: 236 amino acids; 26907 Da
Subunit: Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late
endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8 (By similarity).
Interacts with HECTD3 (By similarity)
Secondary accessions: O60712 Q53XT8

Explore the universe of human proteins at neXtProt for STX8: NX_Q9UNK0

Explore proteomics data for STX8 at MOPED

Post-translational modifications: 

  • Ubiquitinated by HECTD3 (By similarity)1
  • Ubiquitination2 at Lys59, Lys98, Lys146
  • Modification sites at PhosphoSitePlus

  • See STX8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004844.1  
    ENSEMBL proteins: 
     ENSP00000305255   ENSP00000460355   ENSP00000467749   ENSP00000468093   ENSP00000460073  

    STX8 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for STX8
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    Sino Biological Cell Lysate for STX8
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    Cloud-Clone Corp. Proteins for STX8

     
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    STX8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of STX8
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    LSBio Antibodies in human, mouse, rat for STX8

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    Cloud-Clone Corp. ELISAs for STX8
    Cloud-Clone Corp. CLIAs for STX8
    Search eBioscience for ELISAs for STX8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000727 T_SNARE_dom
     IPR015640 Syntax_8

    Graphical View of Domain Structure for InterPro Entry Q9UNK0

    ProtoNet protein and cluster: Q9UNK0

    UniProtKB/Swiss-Prot: STX8_HUMAN, Q9UNK0
    Similarity: Belongs to the syntaxin family
    Similarity: Contains 1 t-SNARE coiled-coil homology domain


    Find genes that share domains with STX8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STX8_HUMAN, Q9UNK0
    Function: Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating
    retrograde transport from cis-Golgi membranes to the ER

         Genatlas biochemistry entry for STX8:
    syntaxin 8,forming a synaptic core complex with synaptosome associated proteins,binding to N-type Ca2+
    channels,involved in the intracellular membrane transport and exocytosis,soluble N ethylmaleimide-sensitive
    factor-attachment protein receptor,SNARE protein

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005484SNAP receptor activity IBA--
    GO:0005515protein binding ----
    GO:0031625ubiquitin protein ligase binding IEA--
         
    Find genes that share ontologies with STX8           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STX8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STX8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STX8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STX8

    miRNA
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    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for STX8
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    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STX8 (NM_004853)
    Sino Biological Human cDNA Clone for STX8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STX8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX8

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for STX8 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STX8_HUMAN, Q9UNK0: Membrane; Single-pass type IV membrane protein (By similarity). Note=Preferentially
    associated with the early endosome. To lesser extends, also present in late endosome, the plasma membrane and
    coated pits (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    plasma membrane4
    cytosol3
    endosome2
    lysosome2
    vacuole2
    cytoskeleton1
    extracellular1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--
    GO:0005783endoplasmic reticulum TAS9852078
    GO:0005887integral component of plasma membrane TAS10198254
    GO:0031201SNARE complex IBA--
    GO:0031902late endosome membrane IEA--

    Find genes that share ontologies with STX8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STX8 About    
    See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    2Clathrin dependent protein traffic
    Transport Clathrin coated vesicle cycle0.66
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    3Transmission across Chemical Synapses
    Neuronal System0.68
    4wtCFTR and deltaF508 traffic Late endosome and Lysosome norm and CF
    wtCFTR and deltaF508 traffic Late endosome and Lysosome norm and CF
    5Disease
    Disease


    Find genes that share SuperPaths with STX8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for STX8
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Transport Clathrin-coated vesicle cycle
    wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)


    1 PharmGKB Pathway for STX8
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    1 Kegg Pathway  (Kegg details for STX8):
        SNARE interactions in vesicular transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STX8
    Interactions:

        GeneGlobe Interaction Network for STX8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STX8 (Q9UNK02, 3 ENSP000003052554) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX7O154002, 3, ENSP000003569184MINT-7255483 MINT-7255586 MINT-7255636 MINT-7255549 MINT-7255609 I2D: score=3 STRING: ENSP00000356918
    STX6O437522, ENSP000002583014MINT-7255483 MINT-7255586 MINT-7255636 MINT-7255549 MINT-7255609 STRING: ENSP00000258301
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS10198254
    GO:0006886intracellular protein transport IBA--
    GO:0006906vesicle fusion IBA--
    GO:0008333endosome to lysosome transport IEA--
    GO:0016192vesicle-mediated transport ----

    Find genes that share ontologies with STX8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STX8

    3 Novoseek inferred chemical compound relationships for STX8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    torulene 88.6 5 16049681 (1), 17493127 (1)
    phytoene 82.2 2 10905351 (1), 17493127 (1)
    carotene 66.1 2 17493127 (1)



    Find genes that share compounds with STX8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STX8 gene: 
    NM_004853.2  

    Unigene Cluster for STX8:

    Syntaxin 8
    Hs.431109  [show with all ESTs]
    Unigene Representative Sequence: BF572338
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306357(uc002glx.3 uc021tqd.1) ENST00000575858 ENST00000570583
    ENST00000570987 ENST00000574431 ENST00000575294 ENST00000574775 ENST00000573016
    ENST00000573881 ENST00000573373 ENST00000574382 ENST00000573077
    miRNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: STX8 (NM_004853)
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    Primer
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    OriGene qPCR primer pairs and template standards for STX8
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STX8
      QuantiTect SYBR Green Assays in human, mouse, rat STX8
      QuantiFast Probe-based Assays in human, mouse, rat STX8

    Additional mRNA sequence: 

    AF036715.1 AF062077.1 AF115323.1 BC009713.1 BC020924.2 BT007319.1 NR_033656.1 

    8 DOTS entries:

    DT.212948  DT.92428149  DT.100782759  DT.92428143  DT.100782760  DT.95164340  DT.426452  DT.95186774 

    Selected AceView cDNA sequences (see all 103):

    C21017 BM354026 BM673124 AI097428 BM142239 CA413942 AF036715 NM_004853 
    BQ029542 BM705168 CB529029 AF062077 BV178935 BU627089 BG716032 C01219 
    BG504506 BT007319 CB528325 BG425195 AF115323 CD365414 BU624458 BM831521 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STX8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGATTTTAC
    STX8 Expression
    About this image


    STX8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    STX8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STX8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.431109

    UniProtKB/Swiss-Prot: STX8_HUMAN, Q9UNK0
    Tissue specificity: Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal
    muscle, spleen and pancreas

        Custom PCR Arrays for STX8
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    QuantiFast Probe-based Assays in human, mouse, rat STX8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STX8 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stx81 , 5 syntaxin 81, 5 88.84(n)1
    92.8(a)1
      11 (41.20 cM)5
    559431  NM_018768.21  NP_061238.11 
     679661935 
    chicken
    (Gallus gallus)
    Aves STX81 syntaxin 8 70.5(n)
    75.74(a)
      417321  NM_001030698.1  NP_001025869.1 
    lizard
    (Anolis carolinensis)
    Reptilia STX86
    syntaxin 8
    74(a)
    1 ↔ 1
    2(105543026-105636062)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.173072 Xenopus laevis transcribed sequence with weak similarity more 75.65(n)    BX844878.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc640792 hypothetical protein MGC64079 69.58(n)   393346  BC053241.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syx81 Syntaxin 8 39.71(n)
    24.4(a)
      39847  NM_079389.4  NP_524113.1 


    ENSEMBL Gene Tree for STX8 (if available)
    TreeFam Gene Tree for STX8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STX8 gene

    Find genes that share paralogs with STX8           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for STX8
    PGOHUM00000239354


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STX8 (see all 7690)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3726206031,2
    C--9138501(+) cacac-/ACAC/AC
    ACACAC
    /CT
    tcaca
    2 -- int10--------
    rs177436161,2
    C,F--9153355(+) CCTCCG/AGCCAG 2 -- ds50015Minor allele frequency- A:0.20NA EA 380
    rs747176341,2
    C--9153400(+) ACAACT/GGGGCC 2 -- ds50014Minor allele frequency- G:0.19CSA WA NA EA 359
    rs47913451,2
    C,F,A--9153546(+) GGGTTG/CAAGCA 2 -- ds50016Minor allele frequency- C:0.50NA CSA 14
    rs1129198381,2
    F--9153690(+) AGGTGT/ATCCGC 2 -- ds50012Minor allele frequency- A:0.50CSA 4
    rs1830911881,2
    --9153693(+) TGATCC/TGCCCG 2 -- ds50010--------
    rs1460763991,2
    --9153750(+) CCGGCC/TGGAGC 2 -- ds50010--------
    rs89741,2
    C,F,O,A,H--9153861(-) ACCTGC/GCAATG 2 -- nc-transcript-variantut31 ese332Minor allele frequency- G:0.28MN EA NS NA WA CSA 4736
    rs1418463281,2
    F--9153905(+) TGGTCG/AGCCAG 3 /P /L nc-transcript-variantmis11Minor allele frequency- A:0.00NA 4336
    rs169581051,2
    C,F--9153925(+) ACCACA/C/GATAGC 5 I M nc-transcript-variantmis1 syn1 ese38NA CSA EU 5722

    HapMap Linkage Disequilibrium report for STX8 (9153788 - 9403788 bp, first 250kb of STX8)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STX8 (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715632CNV Deletion23290073
    esv2661306CNV Deletion23128226
    esv2661151CNV Deletion23128226
    esv2663291CNV Deletion23128226
    esv2715631CNV Deletion23290073
    nsv436063CNV Insertion17901297
    nsv1974CNV Insertion18451855
    nsv1973CNV Insertion18451855
    nsv153CNV Insertion15895083
    nsv1972CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STX8
    DNA2.0 Custom Variant and Variant Library Synthesis for STX8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604203    OMIM disorders: --

    1 disease for STX8:    
    About MalaCards
    visual epilepsy

    1 disease from the University of Copenhagen DISEASES database for STX8:
    Visual epilepsy

    Find genes that share disorders with STX8           About GenesLikeMe

    Genetic Association Database (GAD): STX8
    Human Genome Epidemiology (HuGE) Navigator: STX8 (4 documents)

    Export disorders for STX8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STX8 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with STX8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8). (PubMed id 10198254)1, 2, 3, 9 Thoreau V.... Chomel J.-C. (Biochem. Biophys. Res. Commun. 1999)
    2. Three novel proteins of the syntaxin/SNAP-25 family. (PubMed id 9852078)1, 2, 3 Steegmaier M....Scheller R.H. (J. Biol. Chem. 1998)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. (PubMed id 20886065)1, 4 Cleynen I....Vermeire S. (PLoS ONE 2010)
    5. Genetic risk profiling and prediction of disease course in Crohn's disease patients. (PubMed id 19422935)1, 4 Henckaerts L....Vermeire S. (Clin. Gastroenterol. Hepatol. 2009)
    6. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. (PubMed id 19174780)1, 4 Weersma R.K.... Vermeire S. (Am. J. Gastroenterol. 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Syntaxin 8 has two functionally distinct di-leucine-based motifs. (PubMed id 17965969)1, 9 Kasai K....Akagawa K. (amp 2008)
    9. Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8. (PubMed id 18980942)1, 9 He Y. and Linder M.E. (J. Lipid Res. 2009)
    10. Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease. (PubMed id 14991845)1, 9 Zhu X....Smith M.A. (J. Neurosci. Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9482 HGNC: 11443 AceView: STX8 Ensembl:ENSG00000170310 euGenes: HUgn9482
    ECgene: STX8 Kegg: 9482 H-InvDB: STX8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STX8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for STX8 gene:
    Search GeneIP for patents involving STX8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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