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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STX8 Gene

protein-coding   GIFtS: 57
GCID: GC17M009153

syntaxin 8
 Explore 8 diseases affiliated with
STX8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STX8    

Aliases
for STX8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Syntaxin 81 2
CARB1 2
CIP-1-Associated Regulator Of Cyclin B2
Syntaxin-81

External Ids:    HGNC: 114431   Entrez Gene: 94822   Ensembl: ENSG000001703107   OMIM: 6042035   UniProtKB: Q9UNK03   
ORGUL members:         
NONCODE:n409304    

Export aliases for STX8 gene to outside databases

Previous GC identifers: GC17M009501 GC17M010245 GC17M009096 GC17M009354 GC17M009094


Summaries
for STX8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for STX8:
The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late
endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: STX8_HUMAN, Q9UNK0
Function: Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde
transport from cis-Golgi membranes to the ER

Gene Wiki entry for STX8


Genomic Views
for STX8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STX8 gene promoter:
         AML1a   MEF-2   MyoD   HNF-4alpha1   MEF-2A   Nkx6-1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STX8 promoter sequence
   Search SABiosciences Chromatin IP Primers for STX8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

STX8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STX8 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M009153:  view genomic region     (about GC identifiers)

Start:
 9,153,788 bp from pter      End:
 9,479,908 bp from pter
Size:
 326,121 bases      Orientation:
 minus strand

Proteins
for STX8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STX8_HUMAN, Q9UNK0 (See protein sequence)
Recommended Name: Syntaxin-8  
Size: 236 amino acids; 26907 Da
Subunit: Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes.
Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8 (By similarity). Interacts with
HECTD3 (By similarity)
Subcellular location: Membrane; Single-pass type IV membrane protein (By similarity). Note=Preferentially associated
with the early endosome. To lesser extends, also present in late endosome, the plasma membrane and coated pits (By
similarity)
Secondary accessions: O60712 Q53XT8

Explore the universe of human proteins at neXtProt for STX8: NX_Q9UNK0

Post-translational modifications:

  • Ubiquitinated by HECTD3 (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UNK0

    • STX8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004844.1  
    ENSEMBL proteins: 
     ENSP00000460355   ENSP00000305255   ENSP00000467749   ENSP00000468093   ENSP00000460073  
     ENSP00000460220  
    Reactome Protein details: Q9UNK0
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: STX8
    OriGene Custom Protein Services for STX8 
    GenScript Custom Purified and Recombinant Proteins Services for STX8
    Novus Biologicals STX8 Protein
    Novus Biologicals STX8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for STX8

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--
    GO:0005783endoplasmic reticulum TAS9852078
    GO:0005887integral to plasma membrane TAS10198254
    GO:0031201SNARE complex IEA--
    GO:0031902late endosome membrane IEA--


    STX8 for ontologies           About GeneDecksing



    STX8 Antibody Products: 
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    R&D Systems Antibodies for STX8 (Syntaxin 8)
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    Uscn Antibodies for STX8
    Search ThermoFisher Antibodies for STX8

    Assay Products for STX8: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for STX8
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for STX8

    Protein Domains /
    Families
    for STX8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STX8 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000727 T_SNARE_dom
     IPR015640 Syntax_8

    Graphical View of Domain Structure for InterPro Entry Q9UNK0

    ProtoNet protein and cluster: Q9UNK0

    UniProtKB/Swiss-Prot: STX8_HUMAN, Q9UNK0
    Similarity: Belongs to the syntaxin family
    Similarity: Contains 1 t-SNARE coiled-coil homology domain


    Function
    for STX8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STX8_HUMAN, Q9UNK0
    Function: Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde
    transport from cis-Golgi membranes to the ER

         Genatlas biochemistry entry for STX8:
    syntaxin 8,forming a synaptic core complex with synaptosome associated proteins,binding to N-type Ca2+
    channels,involved in the intracellular membrane transport and exocytosis,soluble N ethylmaleimide-sensitive
    factor-attachment protein receptor,SNARE protein

    miRNA
    Products:            		 OriGene 3'-UTR Clone: STX8
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STX8
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate STX8
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STX8 (see all 7)
    OriGene shRNA RFP: STX8
    OriGene siRNA: STX8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX8

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for STX8

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX8 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX8
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX8 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for STX8
    Search LifeMap BioReagents cell lines for STX8

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX8

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031625ubiquitin protein ligase binding IEA--


    STX8 for ontologies           About GeneDecksing



    Pathways & Interactions
    for STX8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Botulinum neurotoxicity
    		Botulinum neurotoxicity1.00
    		Proteolytic cleavage of SNARE complex proteins0.89
    2Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    		Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics1.00
    		SNARE interactions in vesicular transport0.40
    3Clathrin-dependent protein traffic
    		Transport_Clathrin-coated vesicle cycle0.66
    		wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    4wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)
    		wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)1.00
    5Disease
    		Disease1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for STX8
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Transport Clathrin-coated vesicle cycle
    wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)

    4        Reactome Pathways for STX8
        Proteolytic cleavage of SNARE complex proteins
    Botulinum neurotoxicity
    Neuronal System
    Disease

    1 PharmGKB Pathway for STX8
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    1         Kegg Pathway  (Kegg details for STX8):
        SNARE interactions in vesicular transport


    STX8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STX8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for STX8 (Q9UNK02, 3 ENSP000003052554) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX7O154002, 3, ENSP000003569184MINT-7255483 MINT-7255586 MINT-7255636 MINT-7255549 MINT-7255609 I2D: score=3 STRING: ENSP00000356918
    STX6O437522, ENSP000002583014MINT-7255483 MINT-7255586 MINT-7255636 MINT-7255549 MINT-7255609 STRING: ENSP00000258301
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS10198254
    GO:0006906vesicle fusion IEA--
    GO:0008333endosome to lysosome transport IEA--


    STX8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for STX8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STX8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STX8
    3 Novoseek chemical compound relationships for STX8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    torulene 88.6 5 16049681 (1), 17493127 (1)
    phytoene 82.2 2 10905351 (1), 17493127 (1)
    carotene 66.1 2 17493127 (1)

    Search CenterWatch for drugs/clinical trials and news about STX8 

    Transcripts
    for STX8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STX8 gene: 
    NM_004853.2  

    Unigene Cluster for STX8:

    Syntaxin 8
    Hs.431109  [show with all ESTs]
    Unigene Representative Sequence: BF572338
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575858 ENST00000306357(uc002glx.3 uc021tqd.1) ENST00000570583
    ENST00000570987 ENST00000574431 ENST00000575294 ENST00000574775 ENST00000573077
    ENST00000573881 ENST00000573016 ENST00000573373 ENST00000574382

    miRNA
    Products:             		 OriGene 3'-UTR Clone: STX8
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STX8
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate STX8
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STX8 (see all 7)
    OriGene shRNA RFP: STX8
    OriGene siRNA: STX8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX8
    Clone
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    GenScript: all cDNA clones in your preferred vector: STX8 (NM_004853)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STX8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX8 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX8

    Additional cDNA sequence: 

    AF036715.1 AF062077.1 AF115323.1 BC009713.1 BC020924.2 BT007319.1 NR_033656.1 

    8 DOTS entries:

    DT.212948  DT.92428149  DT.100782759  DT.92428143  DT.100782760  DT.95164340  DT.426452  DT.95186774 

    24/103 AceView cDNA sequences (see all 103):

    BM142239 BM354026 C21017 BM673124 CA413942 AI097428 BU153417 BU185746 
    AF036715 NM_004853 BU627089 BQ029542 BV178935 AF062077 BM705168 C01219 
    BG504506 AF115323 CD365414 BU624458 BG425195 CD242001 BM831521 CB528325 

    GeneLoc Exon Structure


    Expression
    for STX8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STX8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGATTTTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See STX8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STX8

    SOURCE GeneReport for Unigene cluster: Hs.431109

    UniProtKB/Swiss-Prot: STX8_HUMAN, Q9UNK0
    Tissue specificity: Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle,
    spleen and pancreas

        SABiosciences Custom PCR Arrays for STX8
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX8

    Orthologs
    for STX8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STX8 gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Stx81 , 5 syntaxin 81, 5 88.84(n)1
    92.8(a)1    		   11 (41.20 cM)5
    559431  NM_018768.21  NP_061238.11 
     679661935 
    chicken
    (Gallus gallus)    		 Aves STX81 syntaxin 8 70.5(n)
    75.74(a)    		   417321  NM_001030698.1  NP_001025869.1 
    lizard
    (Anolis carolinensis)    		 Reptilia STX86
    		 --
    		 73(a)
    		 1 ↔ 1
    		 2(105611817-105635751)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.173072 Xenopus laevis transcribed sequence with weak similarity more 75.65(n)    BX844878.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc640792 hypothetical protein MGC64079 69.58(n)   393346  BC053241.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Syx81 Syntaxin 8 40.72(n)
    26.7(a)    		   39847  NM_079389.3  NP_524113.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SYP516
    SYP526
    (see all 4)    		 syntaxin-52
    (see all 4)    		 24(a)
    22(a)
    (see all 4)    		 many → 1
    many → 1
    (see all 4)    		 1(5555007-5556841)
    1(29946237-29948774)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 SNARE domain containing protein, putative, express...
    SNARE domain containing protein, putative, express...
    		 25(a)
    23(a)
    		 many → 1
    many → 1
    		 2(1022071-1024751)
    8(10758598-10762670)


    ENSEMBL Gene Tree for STX8 (if available)
    TreeFam Gene Tree for STX8 (if available) 

    Paralogs
    for STX8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STX8 gene

    STX8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STX8
    PGOHUM00000239354


    Genomic Variants
    for STX8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6621 NCBI SNPs in STX8 are shown (see all 6621)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs177436161,2
    		C,F,--9153355(+) CCTCCG/AGCCAG 2 -- ds50015Minor allele frequency- A:0.20NA EA 380
    rs747176341,2
    		C,--9153400(+) ACAACT/GGGGCC 2 -- ds50014Minor allele frequency- G:0.19CSA WA NA EA 359
    rs47913451,2
    		C,F,A,--9153546(+) GGGTTG/CAAGCA 2 -- ds50016Minor allele frequency- C:0.50NA CSA 14
    rs1129198381,2
    		F--9153690(+) AGGTGT/ATCCGC 2 -- ds50012Minor allele frequency- A:0.50CSA 4
    rs1830911881,2
    		--9153693(+) TGATCC/TGCCCG 2 -- ds50010--------
    rs1460763991,2
    		--9153750(+) CCGGCC/TGGAGC 2 -- ds50010--------
    rs89741,2
    		C,F,O,A,H,--9153861(-) ACCTGC/GCAATG 2 -- ut31 nc-transcript-variantese332Minor allele frequency- G:0.28MN EA NS NA WA CSA 4736
    rs1418463281,2
    		F--9153905(+) TGGTCG/AGCCAG 3 /P /L nc-transcript-variantmis11Minor allele frequency- A:0.00NA 4336
    rs169581051,2
    		C,F,--9153925(+) ACCACA/C/GATAGC 5 I M mis1 syn1 ese38NA CSA EU 5722
    rs177436591,2
    		C,F,H,--9154078(+) AGTTTG/CTACGA 2 -- int117Minor allele frequency- C:0.38NA NS EA WA CSA 935

    HapMap Linkage Disequilibrium report for STX8 (9153788 - 9403788 bp, first 250kb of STX8)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for STX8
         7 CNVs: 0493 7177 67132 67131 35523 5851 49949
         1 Indel: 102400

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    Disorders / Diseases
    for STX8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STX8 for disorders           About GeneDecksing

    OMIM gene information: 604203    OMIM disorders: --

    8 diseases for STX8:    About MalaCards
    fanconi's anemia    cystic fibrosis    crohn's disease    parkinson's disease
    anemia    fibrosis    alzheimer's disease    neuronitis

    1 disease from the University of Copenhagen DISEASES database for STX8:
    Visual epilepsy
    Human Genome Epidemiology (HuGE) Navigator: STX8 (4 documents)

    Export disorders for STX8 gene to outside databases

    Publications
    for STX8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STX8 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with STX8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8). (PubMed id 10198254)1, 2, 3, 9 Thoreau V.... Chomel J.-C. (1999)
    2. Three novel proteins of the syntaxin/SNAP-25 family. (PubMed id 9852078)1, 2, 3 Steegmaier M....Scheller R.H. (1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Syntaxin 8 has two functionally distinct di-leucine-based motifs. (PubMed id 17965969)1, 9 Kasai K....Akagawa K. (2008)
    5. Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8. (PubMed id 18980942)1, 9 He Y. and Linder M.E. (2009)
    6. Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease. (PubMed id 14991845)1, 9 Zhu X....Smith M.A. (2004)
    7. Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. (PubMed id 10564279)1, 9 Prekeris R.... Scheller R.H. (1999)
    8. Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells. (PubMed id 18570918)1, 9 Bilan F....Thoreau V. (2008)
    9. A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function. (PubMed id 11101518)1, 9 Antonin W....Jahn R. (2000)
    10. Defective HIV-1 particle assembly in AP-3-deficient ce lls derived from patients with Hermansky-Pudlak syndrome type 2. (PubMed id 22875976)1 Liu L....Dong X. (2012)

    External Searches for STX8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
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    Genome Databases showing STX8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9482 HGNC: 11443 AceView: STX8 Ensembl:ENSG00000170310 euGenes: HUgn9482
    ECgene: STX8 Kegg: 9482 H-InvDB: STX8

    Other Databases showing STX8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STX8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STX8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for STX8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STX8 gene:
    Search GeneIP for patents involving STX8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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