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STX7 Gene

protein-coding   GIFtS: 60
GCID: GC06M132767

Syntaxin 7

  Search for STX7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Syntaxin 71 2
syntaxin-72

External Ids:    HGNC: 114421   Entrez Gene: 84172   Ensembl: ENSG000000799507   OMIM: 6032175   UniProtKB: O154003   

Export aliases for STX7 gene to outside databases

Previous GC identifers: GC06M132404 GC06M132624 GC06M132761 GC06M132822 GC06M130353


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STX7 Gene:
STX7 (syntaxin 7) is a protein-coding gene. GO annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is STX12.

UniProtKB/Swiss-Prot: STX7_HUMAN, O15400
Function: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in
homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late
endosomes and lysosomes

Gene Wiki entry for STX7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the STX7 gene promoter:
         c-Fos   GR   AP-1   NCX/Ncx   HNF-3beta   PPAR-gamma1   Chx10   c-Jun   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTX7 promoter sequence
   Search Chromatin IP Primers for STX7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STX7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23.1   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23.1

STX7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STX7 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M132767:  view genomic region     (about GC identifiers)

Start:
132,767,006 bp from pter      End:
132,834,337 bp from pter
Size:
67,332 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STX7_HUMAN, O15400 (See protein sequence)
Recommended Name: Syntaxin-7  
Size: 261 amino acids; 29816 Da
Subunit: Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late
endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for
heterotypic fusion of late endosomes with lysosomes (By similarity). Interacts with VPS11, VPS16 and VPS18.
Interacts with VPS33A
Secondary accessions: E1P579 Q5SZW2 Q96ES9
Alternative splicing: 2 isoforms:  O15400-1   O15400-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STX7: NX_O15400

Explore proteomics data for STX7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys24, Lys71
  • Modification sites at PhosphoSitePlus

  • See STX7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003560.2  
    ENSEMBL proteins: 
     ENSP00000356918   ENSP00000356914  

    STX7 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for STX7
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    Sino Biological Cell Lysate for STX7
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    Cloud-Clone Corp. Proteins for STX7

     
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    Search eBioscience for ELISAs for STX7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000727 T_SNARE_dom
     IPR010989 t-SNARE
     IPR006011 Syntaxin_N
     IPR006012 Syntaxin/epimorphin_CS

    Graphical View of Domain Structure for InterPro Entry O15400

    ProtoNet protein and cluster: O15400

    1 Blocks protein domain: IPB006011 Syntaxin

    UniProtKB/Swiss-Prot: STX7_HUMAN, O15400
    Similarity: Belongs to the syntaxin family
    Similarity: Contains 1 t-SNARE coiled-coil homology domain


    Find genes that share domains with STX7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STX7_HUMAN, O15400
    Function: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in
    homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late
    endosomes and lysosomes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding IBA--
    GO:0005484SNAP receptor activity IBA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with STX7           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STX7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STX7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STX7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STX7

    miRNA
    Products:
        
    miRTarBase miRNAs that target STX7:
    hsa-mir-192-5p (MIRT004164), hsa-mir-215-5p (MIRT024345), hsa-mir-30a-5p (MIRT005199), hsa-mir-193b-3p (MIRT041281)

    Block miRNA regulation of human, mouse, rat STX7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STX7 (see all 52):
    hsa-miR-548j hsa-miR-3685 hsa-miR-128 hsa-miR-301a hsa-miR-488 hsa-miR-548l hsa-miR-10b* hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidSTX7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STX7
    Predesigned siRNA for gene silencing in human, mouse, rat STX7

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for STX7 (see all 7)
    OriGene ORF clones in mouse, rat for STX7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STX7 (NM_003569)
    Sino Biological Human cDNA Clone for STX7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STX7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX7
    Addgene plasmids for STX7 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STX7_HUMAN, O15400: Early endosome membrane; Single-pass type IV membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol3
    lysosome2
    plasma membrane2
    vacuole2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0031201SNARE complex IBA--
    GO:0031901early endosome membrane IEA--

    Find genes that share ontologies with STX7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STX7 About    
    See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    2Transmission across Chemical Synapses
    Neuronal System0.68
    3Clathrin dependent protein traffic
    Transport Clathrin coated vesicle cycle0.66
    4Phagosome
    Phagosome
    5Disease
    Disease


    Find genes that share SuperPaths with STX7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for STX7
        Transport Clathrin-coated vesicle cycle


    1 PharmGKB Pathway for STX7
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    2 Kegg Pathways  (Kegg details for STX7):
        SNARE interactions in vesicular transport
    Phagosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STX7
    Interactions:

        GeneGlobe Interaction Network for STX7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STX7 (O154002, 3 ENSP000003569184) via UniProtKB, MINT, STRING, and/or I2D (see all 158)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX8Q9UNK02, 3, ENSP000003052554MINT-7255483 MINT-7255586 MINT-7255636 MINT-7255549 MINT-7255609 I2D: score=3 STRING: ENSP00000305255
    VAMP7P518092, 3, ENSP000002864484MINT-7255549 I2D: score=2 STRING: ENSP00000286448
    MAPK6Q166592, 3MINT-8262066 I2D: score=2 
    STX6O437522, 3, ENSP000002583014MINT-7255483 MINT-7255586 MINT-7255636 MINT-7255549 MINT-7255609 I2D: score=3 STRING: ENSP00000258301
    VAMP8Q9BV402, 3, ENSP000002638644MINT-7255609 I2D: score=3 STRING: ENSP00000263864
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IBA--
    GO:0006892post-Golgi vesicle-mediated transport TAS9358037
    GO:0016079synaptic vesicle exocytosis IBA--
    GO:0016192vesicle-mediated transport ----

    Find genes that share ontologies with STX7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STX7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STX7 gene: 
    NM_003569.2  

    Unigene Cluster for STX7:

    Syntaxin 7
    Hs.593148  [show with all ESTs]
    Unigene Representative Sequence: NM_003569
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367941(uc003qdg.2 uc011ecg.1 uc011ech.1) ENST00000367937
    ENST00000448348 ENST00000475879
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STX7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STX7 (see all 52):
    hsa-miR-548j hsa-miR-3685 hsa-miR-128 hsa-miR-301a hsa-miR-488 hsa-miR-548l hsa-miR-10b* hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidSTX7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STX7
    Predesigned siRNA for gene silencing in human, mouse, rat STX7
    Clone
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    OriGene clones in human, mouse for STX7 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STX7 (NM_003569)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STX7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX7
    Addgene plasmids for STX7 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STX7
    OriGene qSTAR qPCR primer pairs in human, mouse for STX7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STX7
      QuantiTect SYBR Green Assays in human, mouse, rat STX7
      QuantiFast Probe-based Assays in human, mouse, rat STX7

    Additional mRNA sequence: 

    AF131808.1 AJ420529.1 AK294911.1 AK301464.1 BC011975.1 U77942.1 

    18 DOTS entries:

    DT.95208535  DT.215965  DT.100814407  DT.101984526  DT.121387057  DT.100716316  DT.121387077  DT.121387090 
    DT.100814406  DT.40132581  DT.92014308  DT.99940584  DT.100814400  DT.92005992  DT.92433166  DT.95208538 
    DT.95208542  DT.40132582 

    Selected AceView cDNA sequences (see all 390):

    BU193688 AA830303 AI805300 AI476006 BF064142 AA100827 CR607128 AI636831 
    AA081693 CD513700 BM554109 N40628 CR596095 BC011975 AI341494 CR615646 
    AW576275 AI290215 Z45822 AA045075 AI439201 AA147512 BE048037 BQ677272 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STX7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGAAAAAAT
    STX7 Expression
    About this image


    STX7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    STX7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STX7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.593148

    UniProtKB/Swiss-Prot: STX7_HUMAN, O15400
    Tissue specificity: Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain.
    Low expression is found in pancreas, lung and liver

        Custom PCR Arrays for STX7
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    QuantiFast Probe-based Assays in human, mouse, rat STX7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STX7 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stx71 , 5 syntaxin 71, 5 87.64(n)1
    94.98(a)1
      10 (11.45 cM)5
    533311  NM_016797.41  NP_058077.21 
     241493175 
    chicken
    (Gallus gallus)
    Aves STX71 syntaxin 7 79.97(n)
    82.21(a)
      426930  NM_001012943.1  NP_001012961.1 
    lizard
    (Anolis carolinensis)
    Reptilia STX76
    syntaxin 7
    78(a)
    1 ↔ 1
    GL343200.1(4505253-4532948)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC531612 similar to syntaxin 7 73.84(n)    BC046851.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stx7l1 syntaxin 7-like 61.54(n)
    59.92(a)
      562669  XM_003200760.2  XP_003200808.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syx71 Syntaxin 7 50.37(n)
    47.09(a)
      36173  NM_168905.2  NP_730632.1 
    worm
    (Caenorhabditis elegans)
    Secernentea syx-76
    Protein SYX-7 (syx-7) mRNA, complete cds
    27(a)
    1 → many
    I(9001911-9003963) WBGene00009478
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PEP126
    Target membrane receptor (t-SNARE) for vesicular i...
    20(a)
    1 → many
    XV(400348-401214) YOR036W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VAM31 VAM3 44.15(n)
    34.21(a)
      834730  NM_124057.3  NP_568671.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g02549001 Os01g0254900 43.75(n)
    34.37(a)
      4327713  NM_001049155.1  NP_001042620.1 


    ENSEMBL Gene Tree for STX7 (if available)
    TreeFam Gene Tree for STX7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STX7 gene
    STX122  TSNARE12  
    2 SIMAP similar genes for STX7 using alignment to 1 protein entry:     STX7_HUMAN:
    STX12    TSNARE1

    Find genes that share paralogs with STX7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STX7 (see all 1282)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895442751,2
    --132778202(+) AACAGC/TACAGC 1 -- ds50010--------
    rs1427451261,2
    --132778214(+) TTCTGC/GATGTT 1 -- ds50010--------
    rs1814127421,2
    --132778220(+) ATGTTC/TTCAAG 1 -- ds50010--------
    rs37347461,2
    C,F--132778348(+) TCCATC/GAAGTG 1 -- ds50010--------
    rs65697981,2
    C,F,H--132778538(+) TATCTC/TTCATG 1 -- ds500117Minor allele frequency- T:0.28NA NS EA WA CSA 932
    rs1380886261,2
    --132778588(+) AAAAAA/CTGGTT 1 -- ds50010--------
    rs1895449751,2
    C--132778664(+) TACACC/TGTAAC 1 -- ut310--------
    rs753203091,2
    C,F--132778685(+) TCCCAT/CTGGTT 1 -- ut312Minor allele frequency- C:0.15CSA WA 120
    rs1417943291,2
    C--132778700(+) ATTTGA/GTAAGT 1 -- ut310--------
    rs1818217551,2
    --132778869(+) TCATAC/TTTAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for STX7 (132767006 - 132834337 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STX7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819019CNV Loss19587683
    nsv830811CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603217    OMIM disorders: --


    Find genes that share disorders with STX7           About GenesLikeMe

    Genetic Association Database (GAD): STX7
    Human Genome Epidemiology (HuGE) Navigator: STX7 (1 document)

    Export disorders for STX7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STX7 gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with STX7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes. (PubMed id 9358037)1, 2, 3, 9 Wang H.... Pevsner J. (Gene 1997)
    2. Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. (PubMed id 10564279)1, 2, 9 Prekeris R.... Scheller R.H. (Mol. Biol. Cell 1999)
    3. Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. (PubMed id 11382755)1, 2, 9 Kim B.Y....Akazawa C. (J. Biol. Chem. 2001)
    4. No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. (PubMed id 18198266)1, 4 Sanders A.R....Gejman P.V. (Am J Psychiatry 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. Syntaxin 7 mediates endocytic trafficking to late endosomes. (PubMed id 10692457)1, 2 Nakamura N.... Futai M. (J. Biol. Chem. 2000)
    9. Syntaxin 7, a novel syntaxin member associated with the early endosomal compartment. (PubMed id 9417091)1, 9 Wong S.H....Hong W. (J. Biol. Chem. 1998)
    10. Intracellular location of syntaxin 7 in human neutrophils. (PubMed id 20170677)1, 9 Xie L.X....Mollinedo F. (Immunol. Lett. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8417 HGNC: 11442 AceView: STX7 Ensembl:ENSG00000079950 euGenes: HUgn8417
    ECgene: STX7 Kegg: 8417 H-InvDB: STX7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STX7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STX7 gene:
    Search GeneIP for patents involving STX7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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