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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STX7 Gene

protein-coding   GIFtS: 59
GCID: GC06M132822

syntaxin 7
 Explore 4 diseases affiliated with
STX7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STX7    

Aliases
for STX7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Syntaxin 71 2
Syntaxin-71

External Ids:    HGNC: 114421   Entrez Gene: 84172   Ensembl: ENSG000000799507   OMIM: 6032175   UniProtKB: O154003   

Export aliases for STX7 gene to outside databases

Previous GC identifers: GC06M132404 GC06M132624 GC06M132761 GC06M130353


Summaries
for STX7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: STX7_HUMAN, O15400
Function: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in
homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes
and lysosomes

Gene Wiki entry for STX7


Genomic Views
for STX7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STX7 gene promoter:
         c-Fos   GR   AP-1   NCX/Ncx   HNF-3beta   PPAR-gamma1   Chx10   c-Jun   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STX7 promoter sequence
   Search SABiosciences Chromatin IP Primers for STX7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23.1   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23.1

STX7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STX7 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M132822:  view genomic region     (about GC identifiers)

Start:
 132,778,663 bp from pter      End:
 132,834,337 bp from pter
Size:
 55,675 bases      Orientation:
 minus strand

Proteins
for STX7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STX7_HUMAN, O15400 (See protein sequence)
Recommended Name: Syntaxin-7  
Size: 261 amino acids; 29816 Da
Subunit: Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes.
Interacts with VPS33A. Found in a complex with VAMP8 and VTI1B in the liver. Part of the SNARE core complex containing
VAMP8, STX8 and VTI1B (By similarity). Interacts with VPS11, VPS16 and VPS18
Subcellular location: Early endosome membrane; Single-pass type IV membrane protein (By similarity)
Secondary accessions: E1P579 Q5SZW2 Q96ES9
Alternative splicing: 2 isoforms:  O15400-1   O15400-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STX7: NX_O15400

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15400

    • STX7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003560.2  
    ENSEMBL proteins: 
     ENSP00000356918   ENSP00000412202   ENSP00000356914  
    Reactome Protein details: O15400
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: STX7
    OriGene Custom Protein Services for STX7 
    GenScript Custom Purified and Recombinant Proteins Services for STX7
    Novus Biologicals STX7 Protein
    Novus Biologicals STX7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for STX7

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane ----
    GO:0005768endosome ----
    GO:0016021integral to membrane IEA--
    GO:0031201SNARE complex IBA--
    GO:0031901early endosome membrane IEA--


    STX7 for ontologies           About GeneDecksing



    STX7 Antibody Products: 
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    R&D Systems Antibodies for STX7 (Syntaxin 7)
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    ThermoFisher Antibody for STX7

    Assay Products for STX7: 
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    Uscn ELISAs and CLIAs for STX7

    Protein Domains /
    Families
    for STX7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STX7 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000727 T_SNARE_dom
     IPR010989 t-SNARE
     IPR006011 Syntaxin_N
     IPR006012 Syntaxin/epimorphin_CS

    Graphical View of Domain Structure for InterPro Entry O15400

    ProtoNet protein and cluster: O15400

    1 Blocks protein family: IPB006011 Syntaxin

    UniProtKB/Swiss-Prot: STX7_HUMAN, O15400
    Similarity: Belongs to the syntaxin family
    Similarity: Contains 1 t-SNARE coiled-coil homology domain


    Function
    for STX7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STX7_HUMAN, O15400
    Function: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in
    homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes
    and lysosomes

    miRNA
    Products:            		miRTarBase miRNAs that target STX7:
    hsa-mir-192 (MIRT004164), hsa-mir-30a (MIRT005199)

    OriGene 3'-UTR Clone: STX7
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STX7
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate STX7 (see all 52):
    hsa-miR-548j hsa-miR-3685 hsa-miR-128 hsa-miR-301a hsa-miR-488 hsa-miR-548l hsa-miR-10b* hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmid: STX7 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STX7 (see all 7)
    OriGene shRNA RFP: STX7
    OriGene siRNA: STX7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for STX7

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX7 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX7
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: STX7 (NM_003569)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STX7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX7 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for STX7
    Search LifeMap BioReagents cell lines for STX7

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX7

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding IBA--
    GO:0005484SNAP receptor activity IBA--
    GO:0005515protein binding ----
    GO:0032403protein complex binding ----


    STX7 for ontologies           About GeneDecksing



    Pathways & Interactions
    for STX7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Botulinum neurotoxicity
    		Botulinum neurotoxicity1.00
    		Proteolytic cleavage of SNARE complex proteins0.89
    2Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    		Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics1.00
    		SNARE interactions in vesicular transport0.40
    3Disease
    		Disease1.00
    4Phagosome
    		Phagosome1.00
    5Transmission across Chemical Synapses
    		Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for STX7
        Transport Clathrin-coated vesicle cycle

    4        Reactome Pathways for STX7
        Proteolytic cleavage of SNARE complex proteins
    Botulinum neurotoxicity
    Neuronal System
    Disease

    1 PharmGKB Pathway for STX7
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    2         Kegg Pathways  (Kegg details for STX7):
        SNARE interactions in vesicular transport
    Phagosome


    STX7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STX7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/53 Interacting proteins for STX7 (O154002, 3 ENSP000003569184) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX8Q9UNK02, 3, ENSP000003052554MINT-7255483 MINT-7255586 MINT-7255636 MINT-7255549 MINT-7255609 I2D: score=3 STRING: ENSP00000305255
    VAMP7P518092, 3, ENSP000002864484MINT-7255549 I2D: score=2 STRING: ENSP00000286448
    MAPK6Q166592, 3MINT-8262066 I2D: score=2 
    STX6O437522, 3, ENSP000002583014MINT-7255483 MINT-7255586 MINT-7255636 MINT-7255549 MINT-7255609 I2D: score=3 STRING: ENSP00000258301
    VAMP8Q9BV402, 3, ENSP000002638644MINT-7255609 I2D: score=3 STRING: ENSP00000263864
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IBA--
    GO:0006892post-Golgi vesicle-mediated transport TAS9358037
    GO:0006906vesicle fusion ----
    GO:0008333endosome to lysosome transport ----
    GO:0016079synaptic vesicle exocytosis IBA--


    STX7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for STX7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STX7
    Search CenterWatch for drugs/clinical trials and news about STX7 

    Transcripts
    for STX7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STX7 gene: 
    NM_003569.2  

    Unigene Cluster for STX7:

    Syntaxin 7
    Hs.593148  [show with all ESTs]
    Unigene Representative Sequence: NM_003569
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367941(uc003qdg.2 uc011ecg.1 uc011ech.1) ENST00000448348
    ENST00000367937 ENST00000475879

    miRNA
    Products:             		 OriGene 3'-UTR Clone: STX7
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STX7
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate STX7 (see all 52):
    hsa-miR-548j hsa-miR-3685 hsa-miR-128 hsa-miR-301a hsa-miR-488 hsa-miR-548l hsa-miR-10b* hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmid: STX7 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STX7 (see all 7)
    OriGene shRNA RFP: STX7
    OriGene siRNA: STX7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX7
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX7 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX7
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: STX7 (NM_003569)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STX7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX7 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STX7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STX7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX7

    Additional cDNA sequence: 

    AF131808.1 AJ420529.1 AK294911.1 AK301464.1 BC011975.1 U77942.1 

    18 DOTS entries:

    DT.95208535  DT.215965  DT.100814407  DT.101984526  DT.121387057  DT.100716316  DT.121387077  DT.121387090 
    DT.100814406  DT.40132581  DT.92014308  DT.99940584  DT.100814400  DT.92005992  DT.92433166  DT.95208538 
    DT.95208542  DT.40132582 

    24/390 AceView cDNA sequences (see all 390):

    BX358399 BU685568 BQ447011 CB132840 CR618907 AI475487 BQ447974 CA950889 
    N40628 BM974572 AA195685 AW300480 BU193688 AA100827 CD243983 BM771343 
    BX356343 AI630861 AI636831 AL543305 AA081693 AW819832 AI805300 BM911820 

    GeneLoc Exon Structure


    Expression
    for STX7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STX7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGAAAAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    STX7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See STX7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STX7

    SOURCE GeneReport for Unigene cluster: Hs.593148

    UniProtKB/Swiss-Prot: STX7_HUMAN, O15400
    Tissue specificity: Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain. Low
    expression is found in pancreas, lung and liver

        SABiosciences Custom PCR Arrays for STX7
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STX7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STX7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX7
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX7

    Orthologs
    for STX7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STX7 gene from 9/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves STX71 syntaxin 7 79.97(n)
    82.21(a)    		   426930  NM_001012943.1  NP_001012961.1 
    lizard
    (Anolis carolinensis)    		 Reptilia STX76
    		 --
    		 78(a)
    		 1 ↔ 1
    		 GL343200.1(4505307-4532948)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC531612 similar to syntaxin 7 73.84(n)    BC046851.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii stx7l1 syntaxin 7-like 61.65(n)
    60.16(a)    		   562669  XM_003200760.1  XP_003200808.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Syx71 Syntaxin 7 49.52(n)
    43.98(a)    		   36173  NM_168906.1  NP_730633.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea syx-76
    		 SYNtaxin family member (syn-13)
    		 25(a)
    		 1 → many
    		 I(9001904-9003958)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes PEP121 Pep12p 45.88(n)
    27.32(a)    		   854201   NP_014679.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SYP231 syntaxin-23 47.39(n)
    33.48(a)    		   827494  NM_001084934.1  NP_001078403.1 
    rice
    (Oryza sativa)    		 Liliopsida Os01g02549001 hypothetical protein 42.86(n)
    33.06(a)    		   4327713  NM_001049155.1  NP_001042620.1 


    ENSEMBL Gene Tree for STX7 (if available)
    TreeFam Gene Tree for STX7 (if available) 

    Paralogs
    for STX7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STX7 gene
    STX122  TSNARE12  
    2 SIMAP similar genes for STX7 using alignment to 1 protein entry:     STX7_HUMAN:
    STX12    TSNARE1

    STX7 for paralogs           About GeneDecksing



    Genomic Variants
    for STX7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1072 NCBI SNPs in STX7 are shown (see all 1072)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1895442751,2
    		--132778202(+) AACAGC/TACAGC 1 -- ds50010--------
    rs1427451261,2
    		--132778214(+) TTCTGC/GATGTT 1 -- ds50010--------
    rs1814127421,2
    		--132778220(+) ATGTTC/TTCAAG 1 -- ds50010--------
    rs37347461,2
    		C,--132778348(+) TCCATC/GAAGTG 1 -- ds50010--------
    rs65697981,2
    		C,F,H,--132778538(+) TATCTC/TTCATG 1 -- ds500117Minor allele frequency- T:0.28NA NS EA WA CSA 932
    rs1380886261,2
    		--132778588(+) AAAAAA/CTGGTT 1 -- ds50010--------
    rs1895449751,2
    		--132778664(+) TACACC/TGTAAC 1 -- ut310--------
    rs753203091,2
    		--132778685(+) TCCCAT/CTGGTT 1 -- ut312Minor allele frequency- C:0.15CSA WA 120
    rs1417943291,2
    		--132778700(+) ATTTGA/GTAAGT 1 -- ut310--------
    rs1818217551,2
    		--132778869(+) TCATAC/TTTAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for STX7 (132778663 - 132834337 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for STX7
         1 Indel: 59294

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    Disorders / Diseases
    for STX7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STX7 for disorders           About GeneDecksing

    OMIM gene information: 603217    OMIM disorders: --

    4 diseases for STX7:    About MalaCards
    febrile seizures    seizures    schizophrenia    melanoma

    Human Genome Epidemiology (HuGE) Navigator: STX7 (1 document)

    Export disorders for STX7 gene to outside databases

    Publications
    for STX7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STX7 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with STX7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes. (PubMed id 9358037)1, 2, 3, 9 Wang H.... Pevsner J. (1997)
    2. Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. (PubMed id 10564279)1, 2, 9 Prekeris R.... Scheller R.H. (1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Syntaxin 7 mediates endocytic trafficking to late endosomes. (PubMed id 10692457)1, 2 Nakamura N.... Futai M. (2000)
    7. Syntaxin 7, a novel syntaxin member associated with the early endosomal compartment. (PubMed id 9417091)1, 9 Wong S.H....Hong W. (1998)
    8. Intracellular location of syntaxin 7 in human neutrop hils. (PubMed id 20170677)1, 9 Xie L.X....Mollinedo F. (2010)
    9. Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma. (PubMed id 19714869)1, 9 StrAPmberg S....Ponten F. (2009)
    10. Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8. (PubMed id 18980942)1, 9 He Y. and Linder M.E. (2009)

    External Searches for STX7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    Genome Databases showing STX7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8417 HGNC: 11442 AceView: STX7 Ensembl:ENSG00000079950 euGenes: HUgn8417
    ECgene: STX7 Kegg: 8417 H-InvDB: STX7

    Other Databases showing STX7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STX7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STX7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for STX7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STX7 gene:
    Search GeneIP for patents involving STX7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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