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Aliases for STX6 Gene

Aliases for STX6 Gene

  • Syntaxin 6 2 3
  • Syntaxin-6 3

External Ids for STX6 Gene

Previous GeneCards Identifiers for STX6 Gene

  • GC01M178439
  • GC01M176341
  • GC01M177433
  • GC01M178152
  • GC01M178177
  • GC01M177644
  • GC01M179179
  • GC01M179208
  • GC01M180941
  • GC01M152173

Summaries for STX6 Gene

GeneCards Summary for STX6 Gene

STX6 (Syntaxin 6) is a Protein Coding gene. Among its related pathways are Disease and Cytoskeletal Signaling. GO annotations related to this gene include SNAP receptor activity. An important paralog of this gene is STX10.

UniProtKB/Swiss-Prot for STX6 Gene

  • Involved in intracellular vesicle trafficking

Gene Wiki entry for STX6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX6 Gene

Genomics for STX6 Gene

Regulatory Elements for STX6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STX6 Gene

Start:
180,972,712 bp from pter
End:
181,023,121 bp from pter
Size:
50,410 bases
Orientation:
Minus strand

Genomic View for STX6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX6 Gene

Proteins for STX6 Gene

  • Protein details for STX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43752-STX6_HUMAN
    Recommended name:
    Syntaxin-6
    Protein Accession:
    O43752
    Secondary Accessions:
    • B2R652
    • B4DR17
    • Q5VY08
    • Q6FH83

    Protein attributes for STX6 Gene

    Size:
    255 amino acids
    Molecular mass:
    29176 Da
    Quaternary structure:
    • Binds EEA1. Interacts with VPS45A. Interacts with MARCH2 and MARCH3 (By similarity). Interacts with GOPC. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.

    Three dimensional structures from OCA and Proteopedia for STX6 Gene

    Alternative splice isoforms for STX6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX6 Gene

Proteomics data for STX6 Gene at MOPED

Post-translational modifications for STX6 Gene

  • Ubiquitination at Lys77 and Lys139
  • Modification sites at PhosphoSitePlus

Other Protein References for STX6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STX6 Gene

Domains for STX6 Gene

Protein Domains for STX6 Gene

Suggested Antigen Peptide Sequences for STX6 Gene

Graphical View of Domain Structure for InterPro Entry

O43752

UniProtKB/Swiss-Prot:

STX6_HUMAN :
  • O43752
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX6: view

No data available for Gene Families for STX6 Gene

Function for STX6 Gene

Molecular function for STX6 Gene

UniProtKB/Swiss-Prot Function: Involved in intracellular vesicle trafficking

Gene Ontology (GO) - Molecular Function for STX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 11384996
GO:0019905 syntaxin binding IPI 16154903
genes like me logo Genes that share ontologies with STX6: view

Animal Model Products

miRNA for STX6 Gene

miRTarBase miRNAs that target STX6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STX6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for STX6 Gene

Localization for STX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX6 Gene

Golgi apparatus membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX6 Gene COMPARTMENTS Subcellular localization image for STX6 gene
Compartment Confidence
endosome 5
golgi apparatus 5
plasma membrane 5
cytosol 3
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for STX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 10506127
GO:0005794 Golgi apparatus IDA 19224922
GO:0005802 trans-Golgi network IDA 16154903
GO:0005886 plasma membrane TAS 9697774
GO:0016020 membrane --
genes like me logo Genes that share ontologies with STX6: view

Pathways for STX6 Gene

genes like me logo Genes that share pathways with STX6: view

Pathways by source for STX6 Gene

Gene Ontology (GO) - Biological Process for STX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006906 vesicle fusion IPI 10506127
GO:0007032 endosome organization IEA --
GO:0016192 vesicle-mediated transport --
GO:0032880 regulation of protein localization IMP 16154903
genes like me logo Genes that share ontologies with STX6: view

Compounds for STX6 Gene

(5) Novoseek inferred chemical compound relationships for STX6 Gene

Compound -log(P) Hits PubMed IDs
mannose 6-phosphate 65.8 2
n-ethylmaleimide 33.4 2
phosphatidylinositol 9.09 2
glucose 0 1
calcium 0 1
genes like me logo Genes that share compounds with STX6: view

Transcripts for STX6 Gene

Unigene Clusters for STX6 Gene

Syntaxin 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STX6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11
SP1: - -
SP2: -
SP3:
SP4: - - - -
SP5:

Relevant External Links for STX6 Gene

GeneLoc Exon Structure for
STX6
ECgene alternative splicing isoforms for
STX6

Expression for STX6 Gene

mRNA expression in normal human tissues for STX6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX6 Gene

SOURCE GeneReport for Unigene cluster for STX6 Gene Hs.518417

genes like me logo Genes that share expressions with STX6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STX6 Gene

Orthologs for STX6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STX6 35
  • 99.87 (n)
  • 100 (a)
STX6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STX6 35
  • 92.61 (n)
  • 97.91 (a)
STX6 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
STX6 35
  • 92.61 (n)
  • 97.91 (a)
mouse
(Mus musculus)
Mammalia Stx6 35
  • 91.07 (n)
  • 94.56 (a)
Stx6 16
Stx6 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STX6 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX6 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stx6 35
  • 90.52 (n)
  • 95.4 (a)
chicken
(Gallus gallus)
Aves STX6 35
  • 82.14 (n)
  • 93.25 (a)
STX6 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX6 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2793 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15502 35
stx6 35
  • 73 (n)
  • 78.48 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.11734 35
stx6 35
  • 70.31 (n)
  • 77.73 (a)
stx6 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006251 35
  • 54.61 (n)
  • 55.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syx6 35
  • 57.65 (n)
  • 54.51 (a)
Syx6 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea syx-6 36
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SYP61 35
  • 45.48 (n)
  • 28.44 (a)
rice
(Oryza sativa)
Liliopsida Os01g0963300 35
  • 48.55 (n)
  • 38.97 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01199 35
  • 45.8 (n)
  • 30.18 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tlg1 35
  • 42.18 (n)
  • 27.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7279 36
  • 48 (a)
OneToMany
Species with no ortholog for STX6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX6 Gene

ENSEMBL:
Gene Tree for STX6 (if available)
TreeFam:
Gene Tree for STX6 (if available)

Paralogs for STX6 Gene

Paralogs for STX6 Gene

Selected SIMAP similar genes for STX6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STX6: view

Variants for STX6 Gene

Sequence variations from dbSNP and Humsavar for STX6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1044595 -- 180,974,393(-) TCGGC(A/G)TGCTT utr-variant-3-prime
rs1411478 -- 180,993,146(+) CAGAG(A/G)AGAAG intron-variant
rs2331903 -- 180,981,733(+) CTCTA(C/T)GAAGC intron-variant
rs2331992 -- 181,006,955(+) TTTCA(C/T)GTCAG intron-variant
rs3747957 -- 180,984,717(-) GACAA(C/T)GTGAT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for STX6 Gene

Variant ID Type Subtype PubMed ID
esv2719940 CNV Deletion 23290073
esv2719951 CNV Deletion 23290073

Relevant External Links for STX6 Gene

HapMap Linkage Disequilibrium report
STX6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX6 Gene

Disorders for STX6 Gene

(1) University of Copenhagen DISEASES for STX6 Gene

(1) Novoseek inferred disease relationships for STX6 Gene

Disease -log(P) Hits PubMed IDs
tuberculosis 0 1

Relevant External Links for STX6

Genetic Association Database (GAD)
STX6
genes like me logo Genes that share disorders with STX6: view

No data available for UniProtKB/Swiss-Prot for STX6 Gene

Publications for STX6 Gene

  1. Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. (PMID: 10080545) Martin-Martin B. … Mollinedo F. (J. Leukoc. Biol. 1999) 2 3 4
  2. Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator. (PMID: 20130090) Cheng J. … Guggino W.B. (Mol. Biol. Cell 2010) 3 23
  3. Control of vesicle fusion by a tyrosine phosphatase. (PMID: 15322554) Huynh H. … Mustelin T. (Nat. Cell Biol. 2004) 3 23
  4. MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking. (PMID: 15689499) Nakamura N. … Hirose S. (Mol. Biol. Cell 2005) 3 23
  5. Syntaxin 6, a regulator of the protein trafficking machinery and a target of the p53 family, is required for cell adhesion and survival. (PMID: 18779328) Zhang Y. … Chen X. (J. Biol. Chem. 2008) 3 23

Products for STX6 Gene

  • Addgene plasmids for STX6

Sources for STX6 Gene

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