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Aliases for STX6 Gene

Aliases for STX6 Gene

  • Syntaxin 6 2 3

External Ids for STX6 Gene

Previous GeneCards Identifiers for STX6 Gene

  • GC01M178439
  • GC01M176341
  • GC01M177433
  • GC01M178152
  • GC01M178177
  • GC01M177644
  • GC01M179179
  • GC01M179208
  • GC01M180941
  • GC01M152173
  • GC01M180972

Summaries for STX6 Gene

GeneCards Summary for STX6 Gene

STX6 (Syntaxin 6) is a Protein Coding gene. Diseases associated with STX6 include tauopathy. Among its related pathways are Cytoskeletal Signaling and wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF). GO annotations related to this gene include syntaxin binding and SNAP receptor activity. An important paralog of this gene is STX10.

UniProtKB/Swiss-Prot for STX6 Gene

  • Involved in intracellular vesicle trafficking

Gene Wiki entry for STX6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX6 Gene

Genomics for STX6 Gene

Regulatory Elements for STX6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STX6 Gene

Chromosome:
1
Start:
180,949,690 bp from pter
End:
181,023,121 bp from pter
Size:
73,432 bases
Orientation:
Minus strand

Genomic View for STX6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX6 Gene

Proteins for STX6 Gene

  • Protein details for STX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43752-STX6_HUMAN
    Recommended name:
    Syntaxin-6
    Protein Accession:
    O43752
    Secondary Accessions:
    • B2R652
    • B4DR17
    • Q5VY08
    • Q6FH83

    Protein attributes for STX6 Gene

    Size:
    255 amino acids
    Molecular mass:
    29176 Da
    Quaternary structure:
    • Binds EEA1. Interacts with VPS45A. Interacts with MARCH2 and MARCH3 (By similarity). Interacts with GOPC. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.

    Three dimensional structures from OCA and Proteopedia for STX6 Gene

    Alternative splice isoforms for STX6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX6 Gene

Proteomics data for STX6 Gene at MOPED

Post-translational modifications for STX6 Gene

  • Ubiquitination at Lys 77 and Lys 139
  • Modification sites at PhosphoSitePlus

Other Protein References for STX6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STX6 (STX6)

No data available for DME Specific Peptides for STX6 Gene

Domains & Families for STX6 Gene

Gene Families for STX6 Gene

Protein Domains for STX6 Gene

Suggested Antigen Peptide Sequences for STX6 Gene

Graphical View of Domain Structure for InterPro Entry

O43752

UniProtKB/Swiss-Prot:

STX6_HUMAN :
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX6: view

Function for STX6 Gene

Molecular function for STX6 Gene

UniProtKB/Swiss-Prot Function:
Involved in intracellular vesicle trafficking

Gene Ontology (GO) - Molecular Function for STX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 11384996
GO:0019905 syntaxin binding IPI 16154903
genes like me logo Genes that share ontologies with STX6: view

Phenotypes for STX6 Gene

genes like me logo Genes that share phenotypes with STX6: view

Animal Model Products

miRNA for STX6 Gene

miRTarBase miRNAs that target STX6

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STX6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for STX6 Gene

Localization for STX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX6 Gene

Golgi apparatus membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX6 Gene COMPARTMENTS Subcellular localization image for STX6 gene
Compartment Confidence
endosome 5
golgi apparatus 5
plasma membrane 5
cytoskeleton 2
cytosol 2
lysosome 2
nucleus 2
vacuole 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for STX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 10506127
GO:0005794 Golgi apparatus IDA 19224922
GO:0005802 trans-Golgi network IDA 16154903
GO:0005886 plasma membrane TAS 9697774
GO:0016020 membrane --
genes like me logo Genes that share ontologies with STX6: view

Pathways & Interactions for STX6 Gene

genes like me logo Genes that share pathways with STX6: view

Pathways by source for STX6 Gene

Gene Ontology (GO) - Biological Process for STX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006906 vesicle fusion IPI 10506127
GO:0007032 endosome organization IEA --
GO:0016192 vesicle-mediated transport --
GO:0032880 regulation of protein localization IMP 16154903
genes like me logo Genes that share ontologies with STX6: view

No data available for SIGNOR curated interactions for STX6 Gene

Drugs & Compounds for STX6 Gene

(2) Drugs for STX6 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Ethylmaleimide Experimental Pharma 0
Calcium Nutra 0

(3) Additional Compounds for STX6 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glucose
Mannose 6-phosphate
  • alpha-D-Mannose-6-P
  • alpha-D-Mannose-6-phosphate
  • alpha-delta-Mannose-6-P
  • alpha-delta-Mannose-6-phosphate
  • D-Mannose 6-phosphate
3672-15-9
Phosphatidylinositol
genes like me logo Genes that share compounds with STX6: view

Transcripts for STX6 Gene

Unigene Clusters for STX6 Gene

Syntaxin 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STX6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11
SP1: - -
SP2: -
SP3:
SP4: - - - -
SP5:

Relevant External Links for STX6 Gene

GeneLoc Exon Structure for
STX6
ECgene alternative splicing isoforms for
STX6

Expression for STX6 Gene

mRNA expression in normal human tissues for STX6 Gene

Protein differential expression in normal tissues from HIPED for STX6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (32.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX6 Gene



SOURCE GeneReport for Unigene cluster for STX6 Gene Hs.518417

genes like me logo Genes that share expression patterns with STX6: view

Protein tissue co-expression partners for STX6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STX6 Gene

Orthologs for STX6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STX6 35
  • 92.61 (n)
  • 97.91 (a)
STX6 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STX6 35
  • 92.61 (n)
  • 97.91 (a)
-- 36
  • 74 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Stx6 35
  • 91.07 (n)
  • 94.56 (a)
Stx6 16
Stx6 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STX6 35
  • 99.87 (n)
  • 100 (a)
STX6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stx6 35
  • 90.52 (n)
  • 95.4 (a)
oppossum
(Monodelphis domestica)
Mammalia STX6 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX6 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves STX6 35
  • 82.14 (n)
  • 93.25 (a)
STX6 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX6 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15502 35
stx6 35
  • 73 (n)
  • 78.48 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2793 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11734 35
stx6 35
  • 70.31 (n)
  • 77.73 (a)
stx6 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006251 35
  • 54.61 (n)
  • 55.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syx6 35
  • 57.65 (n)
  • 54.51 (a)
Syx6 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea syx-6 36
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SYP61 35
  • 45.48 (n)
  • 28.44 (a)
rice
(Oryza sativa)
Liliopsida Os01g0963300 35
  • 48.55 (n)
  • 38.97 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01199 35
  • 45.8 (n)
  • 30.18 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tlg1 35
  • 42.18 (n)
  • 27.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7279 36
  • 48 (a)
OneToMany
Species with no ortholog for STX6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX6 Gene

ENSEMBL:
Gene Tree for STX6 (if available)
TreeFam:
Gene Tree for STX6 (if available)

Paralogs for STX6 Gene

Paralogs for STX6 Gene

(1) SIMAP similar genes for STX6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STX6: view

Variants for STX6 Gene

Sequence variations from dbSNP and Humsavar for STX6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs870046 -- 180,953,671(-) TGAAC(C/T)GCGGG intron-variant
rs883859 -- 180,971,452(-) ACCTC(A/G)GTTAT intron-variant
rs944231 -- 180,969,503(-) CTTCA(C/T)ACCCA intron-variant
rs944232 -- 180,969,493(-) AACTC(C/T)CGCCC intron-variant
rs944233 -- 180,969,491(-) CTCCC(A/G)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STX6 Gene

Variant ID Type Subtype PubMed ID
esv2719940 CNV Deletion 23290073
esv2719951 CNV Deletion 23290073

Variation tolerance for STX6 Gene

Residual Variation Intolerance Score: 55.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STX6 Gene

HapMap Linkage Disequilibrium report
STX6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX6 Gene

Disorders for STX6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STX6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tauopathy
  • tauopathies
- elite association
Search STX6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STX6

Genetic Association Database (GAD)
STX6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STX6
genes like me logo Genes that share disorders with STX6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STX6 Gene

Publications for STX6 Gene

  1. A novel syntaxin 6-interacting protein, SHIP164, regulates syntaxin 6-dependent sorting from early endosomes. (PMID: 20163565) Otto G.P. … Tooze S.A. (Traffic 2010) 23 67
  2. Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator. (PMID: 20130090) Cheng J. … Guggino W.B. (Mol. Biol. Cell 2010) 23 67
  3. Neuronal Ca2+ sensor VILIP-1 leads to the upregulation of functional alpha4beta2 nicotinic acetylcholine receptors in hippocampal neurons. (PMID: 19063970) Zhao C.J. … Braunewell K.H. (Mol. Cell. Neurosci. 2009) 23 67
  4. Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network. (PMID: 19620288) PAcrez-Victoria F.J. … Bonifacino J.S. (Mol. Cell. Biol. 2009) 23 67
  5. Endosomal fusion upon SNARE knockdown is maintained by residual SNARE activity and enhanced docking. (PMID: 19624487) Bethani I. … Rizzoli S.O. (Traffic 2009) 23 67

Products for STX6 Gene

Sources for STX6 Gene

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