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STX6 Gene

protein-coding   GIFtS: 61
GCID: GC01M180941

Syntaxin 6

  Search for STX6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Syntaxin 61 2
syntaxin-62

External Ids:    HGNC: 114411   Entrez Gene: 102282   Ensembl: ENSG000001358237   OMIM: 6039445   UniProtKB: O437523   

Export aliases for STX6 gene to outside databases

Previous GC identifers: GC01M178439 GC01M176341 GC01M177433 GC01M178152 GC01M178177 GC01M177644 GC01M179179 GC01M179208 GC01M152173


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STX6 Gene:
STX6 (syntaxin 6) is a protein-coding gene. GO annotations related to this gene include SNAP receptor activity. An important paralog of this gene is STX10.

UniProtKB/Swiss-Prot: STX6_HUMAN, O43752
Function: Involved in intracellular vesicle trafficking

Gene Wiki entry for STX6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STX6 gene promoter:
         RFX1   ISGF-3   Elk-1   AML1a   FOXL1   GATA-1   Roaz   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTX6 promoter sequence
   Search Chromatin IP Primers for STX6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.3   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25.3

STX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STX6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M180941:  view genomic region     (about GC identifiers)

Start:
180,941,861 bp from pter      End:
180,992,047 bp from pter
Size:
50,187 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STX6_HUMAN, O43752 (See protein sequence)
Recommended Name: Syntaxin-6  
Size: 255 amino acids; 29176 Da
Subunit: Binds EEA1. Interacts with VPS45A. Interacts with MARCH2 and MARCH3 (By similarity). Interacts with GOPC.
Identified in a complex containing STX6, STX12, VAMP4 and VTI1A
2 PDB 3D structures from and Proteopedia for STX6:
2NPS (3D)        4J2C (3D)    
Secondary accessions: B2R652 Q5VY08 Q6FH83

Explore the universe of human proteins at neXtProt for STX6: NX_O43752

Explore proteomics data for STX6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys77, Lys139
  • Modification sites at PhosphoSitePlus

  • See STX6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273139.1  NP_005810.1  

    ENSEMBL proteins: 
     ENSP00000258301   ENSP00000440188  

    STX6 Human Recombinant Protein Products:

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    Novus Biologicals STX6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for STX6
    Cloud-Clone Corp. Proteins for STX6

     
    Search eBioscience for Proteins for STX6 

    STX6 Antibody Products:

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    STX6 Assay Products:

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    Search eBioscience for ELISAs for STX6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000727 T_SNARE_dom
     IPR010989 t-SNARE
     IPR015260 Syntaxin-6_N
     IPR006012 Syntaxin/epimorphin_CS

    Graphical View of Domain Structure for InterPro Entry O43752

    ProtoNet protein and cluster: O43752

    UniProtKB/Swiss-Prot: STX6_HUMAN, O43752
    Similarity: Belongs to the syntaxin family
    Similarity: Contains 1 t-SNARE coiled-coil homology domain


    Find genes that share domains with STX6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STX6_HUMAN, O43752
    Function: Involved in intracellular vesicle trafficking

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005484SNAP receptor activity IBA--
    GO:0005515protein binding IPI11384996
         
    Find genes that share ontologies with STX6           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STX6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STX6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STX6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STX6

    miRNA
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    miRTarBase miRNAs that target STX6:
    hsa-mir-375 (MIRT019742)

    Block miRNA regulation of human, mouse, rat STX6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STX6 (see all 76):
    hsa-miR-188-5p hsa-miR-106a hsa-miR-938 hsa-miR-30d hsa-miR-519a hsa-miR-1304 hsa-miR-30a hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidSTX6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STX6
    Predesigned siRNA for gene silencing in human, mouse, rat STX6

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: STX6 (NM_005819)
    Sino Biological Human cDNA Clone for STX6
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    Addgene plasmids for STX6 

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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12085) for STX6 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STX6_HUMAN, O43752: Golgi apparatus membrane; Single-pass type IV membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    golgi apparatus5
    plasma membrane5
    cytosol3
    cytoskeleton1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005769early endosome IDA10506127
    GO:0005794Golgi apparatus IDA19224922
    GO:0005802trans-Golgi network ----
    GO:0005886plasma membrane TAS9697774

    Find genes that share ontologies with STX6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STX6 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    2Clathrin dependent protein traffic
    Transport Clathrin coated vesicle cycle0.66
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    3ER to Golgi Transport
    Delta508 CFTR traffic ER to Golgi in CF0.36
    Normal wtCFTR traffic ER to Golgi 0.36
    4Transmission across Chemical Synapses
    Neuronal System0.68
    5Disease
    Disease


    Find genes that share SuperPaths with STX6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for STX6
        Cytoskeletal Signaling

    4 GeneGo (Thomson Reuters) Pathways for STX6
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle


    1 PharmGKB Pathway for STX6
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    1 Kegg Pathway  (Kegg details for STX6):
        SNARE interactions in vesicular transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STX6
    Interactions:

        GeneGlobe Interaction Network for STX6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STX6 (O437522, 3 ENSP000002583014) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VAMP3Q158362, 3, ENSP000000546664MINT-7255586 MINT-7255636 I2D: score=1 STRING: ENSP00000054666
    VAMP4O753792, 3, ENSP000002361924MINT-7255483 MINT-4052274 MINT-4052302 MINT-4052327 MINT-4052351 I2D: score=3 STRING: ENSP00000236192
    STX7O154002, 3, ENSP000003569184MINT-7255483 MINT-7255586 MINT-7255636 MINT-7255549 MINT-7255609 I2D: score=3 STRING: ENSP00000356918
    VTI1AQ96AJ92, 3, ENSP000003767924MINT-4052274 MINT-4052302 MINT-4052327 MINT-4052351 I2D: score=1 STRING: ENSP00000376792
    STX8Q9UNK02, ENSP000003052554MINT-7255483 MINT-7255586 MINT-7255636 MINT-7255549 MINT-7255609 STRING: ENSP00000305255
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IBA--
    GO:0006906vesicle fusion IPI10506127
    GO:0007032endosome organization IEA--
    GO:0016192vesicle-mediated transport ----
    GO:0042147retrograde transport, endosome to Golgi IMP19224922

    Find genes that share ontologies with STX6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STX6

    5 Novoseek inferred chemical compound relationships for STX6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 65.8 2 10594043 (1), 20163565 (1)
    n-ethylmaleimide 33.4 2 16154903 (1), 16565709 (1)
    phosphatidylinositol 9.09 2 12911814 (1), 12702770 (1)
    glucose 0 1 12857877 (1)
    calcium 0 2 19063970 (1)



    Find genes that share compounds with STX6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STX6 gene (2 alternative transcripts): 
    NM_001286210.1  NM_005819.5  

    Unigene Cluster for STX6:

    Syntaxin 6
    Hs.518417  [show with all ESTs]
    Unigene Representative Sequence: NM_005819
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258301(uc021pfr.1 uc010pnr.2) ENST00000469135 ENST00000496476
    ENST00000542060
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STX6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STX6 (see all 76):
    hsa-miR-188-5p hsa-miR-106a hsa-miR-938 hsa-miR-30d hsa-miR-519a hsa-miR-1304 hsa-miR-30a hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidSTX6 3' UTR sequence
    Inhib. RNA
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    Flow Cytometry
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    Additional mRNA sequence: 

    AF038202.1 AJ002078.1 AK299063.1 AK312440.1 BC009944.2 CR541856.1 CR541873.1 

    9 DOTS entries:

    DT.40287936  DT.452088  DT.91761266  DT.100681426  DT.121378171  DT.97822919  DT.432087  DT.100782052 
    DT.95163330 

    Selected AceView cDNA sequences (see all 159):

    BU179596 AI492907 BF589090 F13155 BC009944 AI651124 AA337908 BX475069 
    CR608098 AA975205 BI917353 AI638839 AA331328 AA805570 NM_005819 AI144442 
    BX352742 AW043915 AW090657 AW068974 CR610805 CR609438 BQ954021 AI090548 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for STX6    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11
    SP1:                    -                       -                                                         
    SP2:                          -                                                                           
    SP3:                                                                                                      
    SP4:                                                                          -     -     -     -         
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for STX6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STX6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    STX6 Expression
    About this image

    STX6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STX6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518417
        Custom PCR Arrays for STX6
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STX6 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stx61 , 5 syntaxin 61, 5 91.07(n)1
    94.56(a)1
      1 (66.46 cM)5
    582441  NM_021433.31  NP_067408.11 
     1551587035 
    chicken
    (Gallus gallus)
    Aves STX61 syntaxin 6 82.14(n)
    93.25(a)
      424413  NM_001006531.1  NP_001006531.1 
    lizard
    (Anolis carolinensis)
    Reptilia STX66
    syntaxin 6
    89(a)
    1 ↔ 1
    4(69841648-69858805)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.27932 Xenopus laevis transcribed sequence with moderate similarity more 77.22(n)    CD254312.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.117342 Transcribed sequence with moderate similarity to protein more 75.36(n)    57048443 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syx61 Syntaxin 6 57.65(n)
    54.51(a)
      40373  NM_206092.2  NP_995814.1 
    worm
    (Caenorhabditis elegans)
    Secernentea syx-66
    Protein SYX-6 (syx-6) mRNA, complete cds
    36(a)
    1 → many
    X(3164525-3165656) WBGene00015789
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SYP611 SYP61 45.48(n)
    28.44(a)
      839749  NM_102617.3  NP_564310.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g09633001 Os01g0963300 48.55(n)
    38.97(a)
      4324558  NM_001052020.1  NP_001045485.1 


    ENSEMBL Gene Tree for STX6 (if available)
    TreeFam Gene Tree for STX6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STX6 gene
    STX102  
    1 SIMAP similar gene for STX6 using alignment to 2 protein entries:     STX6_HUMAN (see all proteins):
    STX10

    Find genes that share paralogs with STX6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STX6 (see all 1081)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
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    ----------
    rs1163367831,2
    C,F--180941684(+) ACATGC/GAGTTA 1 -- int12Minor allele frequency- G:0.01WA EU 687
    rs1864286271,2
    --180941848(+) AGTCCG/TTTTCA 1 -- int10--------
    rs778648721,2
    C,F--180941906(+) TGTACA/GTACTG 1 -- int11Minor allele frequency- G:0.11WA 118
    rs3729061891,2
    C--180942012(+) TAATC-/AAAAAA 1 -- int10--------
    rs1416149141,2
    --180942123(+) GCGGAC/TTTTGC 1 -- int10--------
    rs1382358471,2
    C--180942167(+) AGTCCG/TGTAAC 1 -- int10--------
    rs1907811311,2
    --180942371(+) CAGTAA/CAAGGT 1 -- ut310--------
    rs1829201641,2
    C--180942477(+) TAACAA/GGGAAC 1 -- ut310--------
    rs1495625171,2
    C--180942547(+) CTACCA/GTCTCT 1 -- ut310--------
    rs1442564731,2
    --180942569(+) GTAAAA/TCACTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for STX6 (180941861 - 180992047 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STX6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719940CNV Deletion23290073
    esv2719951CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STX6
    DNA2.0 Custom Variant and Variant Library Synthesis for STX6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 603944    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for STX6:
    Progressive supranuclear palsy

    Find genes that share disorders with STX6           About GenesLikeMe

    1 Novoseek inferred disease relationship for STX6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberculosis 0 1 12702770 (1)

    Genetic Association Database (GAD): STX6

    Export disorders for STX6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STX6 gene, integrated from 10 sources (see all 97):
    (articles sorted by number of sources associating them with STX6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. (PubMed id 10080545)1, 2, 3 Martin-Martin B.... Mollinedo F. (J. Leukoc. Biol. 1999)
    2. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. (PubMed id 21685912)1, 4 HAPglinger G.U....Schellenberg G.D. (Nat. Genet. 2011)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6. (PubMed id 11384996)1, 2 Charest A.... Housman D.E. (J. Biol. Chem. 2001)
    7. Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis. (PubMed id 11001914)1, 9 MartA-n-MartA-n B....Mollinedo F. (Blood 2000)
    8. The Rab5 effector EEA1 interacts directly with syntaxin-6. (PubMed id 10506127)1, 9 Simonsen A.... Stenmark H. (J. Biol. Chem. 1999)
    9. MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking. (PubMed id 15689499)1, 9 Nakamura N.... Hirose S. (Mol. Biol. Cell 2005)
    10. A new syntaxin family member implicated in targeting of intracellular transport vesicles. (PubMed id 8663448)1, 9 Bock J.B....Scheller R.H. (J. Biol. Chem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10228 HGNC: 11441 AceView: STX6 Ensembl:ENSG00000135823 euGenes: HUgn10228
    ECgene: STX6 Kegg: 10228 H-InvDB: STX6

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STX6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for STX6 gene:
    Search GeneIP for patents involving STX6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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