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Aliases for STX5 Gene

Aliases for STX5 Gene

  • Syntaxin 5 2 3
  • STX5A 3 4 6
  • Syntaxin 5A 2 3
  • Syntaxin-5 3
  • SED5 3

External Ids for STX5 Gene

Previous HGNC Symbols for STX5 Gene

  • STX5A

Previous GeneCards Identifiers for STX5 Gene

  • GC11M062331
  • GC11M062574
  • GC11M058904

Summaries for STX5 Gene

Entrez Gene Summary for STX5 Gene

  • This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for STX5 Gene

STX5 (Syntaxin 5) is a Protein Coding gene. Diseases associated with STX5 include endometriosis. Among its related pathways are Disease and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include protein N-terminus binding and SNAP receptor activity.

UniProtKB/Swiss-Prot for STX5 Gene

  • Mediates endoplasmic reticulum to Golgi transport.

Gene Wiki entry for STX5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX5 Gene

Genomics for STX5 Gene

Regulatory Elements for STX5 Gene

Transcription factor binding sites by QIAGEN in the STX5 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STX5 Gene

62,806,860 bp from pter
62,832,091 bp from pter
25,232 bases
Minus strand

Genomic View for STX5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX5 Gene

Proteins for STX5 Gene

  • Protein details for STX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R8T2
    • F8W8Q9
    • Q5U0D4
    • Q7Z3T6
    • Q9BUG1

    Protein attributes for STX5 Gene

    355 amino acids
    Molecular mass:
    39673 Da
    Quaternary structure:
    • Part of a ternary complex containing STX5A, NSFL1C and VCP. Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2, YKT6 and VTI1A (By similarity). Interacts with COG4.

    Three dimensional structures from OCA and Proteopedia for STX5 Gene

    Alternative splice isoforms for STX5 Gene


neXtProt entry for STX5 Gene

Proteomics data for STX5 Gene at MOPED

Post-translational modifications for STX5 Gene

  • Ubiquitination at Lys82, Lys148, and Lys241
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STX5 (STX5)

No data available for DME Specific Peptides for STX5 Gene

Domains for STX5 Gene

Gene Families for STX5 Gene

Protein Domains for STX5 Gene

Suggested Antigen Peptide Sequences for STX5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX5: view

Function for STX5 Gene

Molecular function for STX5 Gene

UniProtKB/Swiss-Prot Function:
Mediates endoplasmic reticulum to Golgi transport.

Gene Ontology (GO) - Molecular Function for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IDA 15215310
GO:0005515 protein binding IPI 18167358
GO:0047485 protein N-terminus binding IPI 19536132
genes like me logo Genes that share ontologies with STX5: view
genes like me logo Genes that share phenotypes with STX5: view

Animal Model Products

miRNA for STX5 Gene

miRTarBase miRNAs that target STX5

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STX5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for STX5 Gene

Localization for STX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX5 Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type IV membrane protein. Golgi apparatus membrane. Note=Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for STX5 Gene COMPARTMENTS Subcellular localization image for STX5 gene
Compartment Confidence
golgi apparatus 5
nucleus 4
cytosol 3
endoplasmic reticulum 2
plasma membrane 2
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with STX5: view

Pathways for STX5 Gene

genes like me logo Genes that share pathways with STX5: view

Pathways by source for STX5 Gene

1 Qiagen pathway for STX5 Gene
2 Reactome pathways for STX5 Gene
1 KEGG pathway for STX5 Gene
1 GeneGo (Thomson Reuters) pathway for STX5 Gene

Gene Ontology (GO) - Biological Process for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0006903 vesicle targeting --
GO:0006906 vesicle fusion IBA --
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with STX5: view

Drugs for STX5 Gene

(1) Novoseek inferred chemical compound relationships for STX5 Gene

Compound -log(P) Hits PubMed IDs
atp 0 2
genes like me logo Genes that share compounds with STX5: view

Transcripts for STX5 Gene

Unigene Clusters for STX5 Gene

Syntaxin 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STX5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - -
SP2: - - -
SP4: -
SP5: -

Relevant External Links for STX5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STX5 Gene

mRNA expression in normal human tissues for STX5 Gene

Protein differential expression in normal tissues for STX5 Gene

This gene is overexpressed in Cervix (13.6) and Peripheral blood mononuclear cells (13.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX5 Gene

SOURCE GeneReport for Unigene cluster for STX5 Gene Hs.654602

genes like me logo Genes that share expressions with STX5: view

Expression partners for STX5 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STX5 Gene

Orthologs for STX5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STX5 35
  • 94.08 (n)
  • 98.59 (a)
STX5 36
  • 99 (a)
(Canis familiaris)
Mammalia STX5 35
  • 93.52 (n)
  • 98.03 (a)
STX5 36
  • 98 (a)
(Mus musculus)
Mammalia Stx5a 35
  • 89.45 (n)
  • 93.79 (a)
Stx5a 16
Stx5a 36
  • 94 (a)
(Pan troglodytes)
Mammalia STX5 35
  • 99.22 (n)
  • 99.67 (a)
STX5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Stx5 35
  • 89.74 (n)
  • 94.67 (a)
(Monodelphis domestica)
Mammalia STX5 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia STX5 36
  • 65 (a)
(Anolis carolinensis)
Reptilia STX5 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1892 35
stx5 35
  • 72.72 (n)
  • 83.99 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14190 35
(Danio rerio)
Actinopterygii stx5a 35
  • 74.59 (n)
  • 80.5 (a)
wufb81g12 35
stx5a 36
  • 80 (a)
stx5al 36
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syx5 35
  • 59.91 (n)
  • 58.36 (a)
Syx5 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea syx-5 35
  • 48.4 (n)
  • 43.42 (a)
syx-5 36
  • 33 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR210C 35
  • 47.77 (n)
  • 40.14 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17798g 35
  • 45.49 (n)
  • 35.38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SED5 35
  • 43.72 (n)
  • 38.04 (a)
SED5 36
  • 30 (a)
SED5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons SYP32 35
  • 48.53 (n)
  • 41.7 (a)
(Oryza sativa)
Liliopsida Os01g0179200 35
  • 48.75 (n)
  • 43.42 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01907 35
  • 51.03 (n)
  • 46.91 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sed5 35
  • 49.23 (n)
  • 41.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2930 36
  • 49 (a)
Species with no ortholog for STX5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX5 Gene

Gene Tree for STX5 (if available)
Gene Tree for STX5 (if available)

Paralogs for STX5 Gene

No data available for Paralogs for STX5 Gene

Variants for STX5 Gene

Sequence variations from dbSNP and Humsavar for STX5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs482331 -- 62,827,858(-) TTAAG(G/T)AACTC intron-variant
rs497980 -- 62,814,543(-) cggaa(A/G)ttggg intron-variant
rs508181 -- 62,817,140(+) CCAGG(C/G)TGGTC intron-variant
rs524034 -- 62,811,766(-) ctcat(C/G)cctgt intron-variant
rs631987 -- 62,811,755(+) gtgct(A/G)ggatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STX5 Gene

Variant ID Type Subtype PubMed ID
nsv897623 CNV Loss 21882294
nsv483055 CNV Loss 15286789
nsv508636 CNV Loss 20534489
nsv509416 CNV Insertion 20534489
esv991674 OTHER Inversion 20482838

Relevant External Links for STX5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX5 Gene

Disorders for STX5 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for STX5 Gene in MalaCards »

(1) Disease for STX5 Gene

Relevant External Links for STX5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with STX5: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for STX5 Gene

Publications for STX5 Gene

  1. Cloning and identification of human syntaxin 5 as a synaptobrevin/VAMP binding protein. (PMID: 9188044) Ravichandran V. … Roche P.A. (J. Mol. Neurosci. 1997) 2 3 4 23
  2. Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. (PMID: 19536132) Laufman O. … Lev S. (EMBO J. 2009) 3 4 23
  3. Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity. (PMID: 11959998) Parlati F. … Rothman J.E. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner. (PMID: 18167358) Diao A. … Lowe M. (J. Biol. Chem. 2008) 3 23
  5. N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex. (PMID: 9325254) Subramaniam V.N. … Hong W. (J. Biol. Chem. 1997) 3 23

Products for STX5 Gene

Sources for STX5 Gene

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