Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STX5 Gene

protein-coding   GIFtS: 61
GCID: GC11M062574

Syntaxin 5

(Previous name: syntaxin 5A)
(Previous symbol: STX5A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Syntaxin 51 2
STX5A1 2 3 5
Syntaxin 5A1 2
SED52
syntaxin-52

External Ids:    HGNC: 114401   Entrez Gene: 68112   Ensembl: ENSG000001622367   OMIM: 6031895   UniProtKB: Q131903   

Export aliases for STX5 gene to outside databases

Previous GC identifers: GC11M062331 GC11M058904


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STX5 Gene:
This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on
cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic
vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a
critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for
endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this
gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for STX5 Gene: 
STX5 (syntaxin 5) is a protein-coding gene. Diseases associated with STX5 include endometriosis, and intrahepatic cholangiocarcinoma, and among its related super-pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Proteolytic cleavage of SNARE complex proteins. GO annotations related to this gene include SNAP receptor activity and protein N-terminus binding.

UniProtKB/Swiss-Prot: STX5_HUMAN, Q13190
Function: Mediates endoplasmic reticulum to Golgi transport (By similarity)

Gene Wiki entry for STX5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STX5 gene promoter:
         AP-1   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTX5 promoter sequence
   Search SABiosciences Chromatin IP Primers for STX5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

STX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STX5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M062574:  view genomic region     (about GC identifiers)

Start:
62,574,369 bp from pter      End:
62,599,560 bp from pter
Size:
25,192 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STX5_HUMAN, Q13190 (See protein sequence)
Recommended Name: Syntaxin-5  
Size: 355 amino acids; 39673 Da
Subunit: Part of a ternary complex containing STX5A, NSFL1C and VCP. Identified in a unique SNARE complex composed
of the Golgi SNAREs GOSR1, GOSR2, YKT6 and VTI1A (By similarity). Interacts with COG4
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type IV membrane
protein (By similarity). Golgi apparatus membrane; Single-pass type IV membrane protein (By similarity)
1 PDB 3D structure from and Proteopedia for STX5:
3EFO (3D)    
Secondary accessions: B2R8T2 Q5U0D4 Q7Z3T6 Q9BUG1
Alternative splicing, Alternative initiation: 3 isoforms:  Q13190-1   Q13190-2   Q13190-3   (Produced by alternative splicing and alternative initiation)

Explore the universe of human proteins at neXtProt for STX5: NX_Q13190

Explore proteomics data for STX5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13190

  • STX5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STX5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001231595.1  NP_003155.2  

    ENSEMBL proteins: 
     ENSP00000367129   ENSP00000294179   ENSP00000378182   ENSP00000434107   ENSP00000432748  
     ENSP00000414289   ENSP00000435973   ENSP00000436495   ENSP00000441428  
    Reactome Protein details: Q13190
    Human Recombinant Protein Products for STX5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for STX5
    OriGene Protein Over-expression Lysate for STX5
    OriGene MassSpec for STX5 
    OriGene Custom Protein Services for STX5
    GenScript Custom Purified and Recombinant Proteins Services for STX5
    Novus Biologicals STX5 Proteins
    Novus Biologicals STX5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STX5 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IDA--

    STX5 for ontologies           About GeneDecksing



    STX5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for STX5 (Syntaxin 5)
    OriGene Antibodies for STX5
    OriGene Custom Antibody Services for STX5
    GenScript Custom Superior Antibodies Services for STX5
    Novus Biologicals STX5 Antibodies
    Abcam antibodies for STX5
    Cloud-Clone Corp. Antibodies for STX5 
    ThermoFisher Antibody for STX5
    LSBio Antibodies in human, mouse, rat for STX5 

    Assay Products for STX5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STX5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STX5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STX5 
    Cloud-Clone Corp. CLIAs for STX5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR000727 T_SNARE_dom
     IPR010989 t-SNARE
     IPR006011 Syntaxin_N
     IPR006012 Syntaxin/epimorphin_CS

    Graphical View of Domain Structure for InterPro Entry Q13190

    ProtoNet protein and cluster: Q13190

    1 Blocks protein domain: IPB006011 Syntaxin

    UniProtKB/Swiss-Prot: STX5_HUMAN, Q13190
    Similarity: Belongs to the syntaxin family
    Similarity: Contains 1 t-SNARE coiled-coil homology domain


    STX5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STX5_HUMAN, Q13190
    Function: Mediates endoplasmic reticulum to Golgi transport (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005484SNAP receptor activity IDA15215310
    GO:0005515protein binding IPI19536132
    GO:0047485protein N-terminus binding IPI19536132
         
    STX5 for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for STX5:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella-containin  Decreased Tat-dependent transc  Decreased p24 protein expressi  Increased cell death HMECs cel 

         1 MGI phenotypic allele for Stx5a (no phenotypes)

    STX5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for STX5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STX5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STX5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STX5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STX5
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate STX5 (see all 23):
    hsa-miR-485-5p hsa-miR-3660 hsa-miR-513a-5p hsa-miR-1271 hsa-miR-431 hsa-miR-629* hsa-miR-133a hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidSTX5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STX5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STX5
    Sirion Biotech Customized adenovirus for overexpression of STX5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for STX5 (see all 9)
    OriGene ORF clones in mouse, rat for STX5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STX5 (NM_003164)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STX5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX5
    Sirion Biotech Customized lentivirus for stable overexpression of STX5 
                         Customized lentivirus expression plasmids for stable overexpression of STX5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STX5
    Search LifeMap BioReagents cell lines for STX5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STX5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    2Botulinum neurotoxicity
    Botulinum neurotoxicity0.89
    Proteolytic cleavage of SNARE complex proteins0.89
    3Transmission across Chemical Synapses
    Neuronal System0.67
    4Clathrin-dependent protein traffic
    Transport Clathrin-coated vesicle cycle0.66
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for STX5
        Transport Clathrin-coated vesicle cycle

    4        Reactome Pathways for STX5
        Proteolytic cleavage of SNARE complex proteins
    Botulinum neurotoxicity
    Neuronal System
    Disease

    1 PharmGKB Pathway for STX5
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    1         Kegg Pathway  (Kegg details for STX5):
        SNARE interactions in vesicular transport


    STX5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STX5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/109 Interacting proteins for STX5 (Q131902, 3 ENSP000002941794) via UniProtKB, MINT, STRING, and/or I2D (see all 109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3MINT-64124 I2D: score=5 
    ENSG00000096155P463792, 3MINT-64124 I2D: score=5 
    ENSG00000227761P463792, 3MINT-64124 I2D: score=5 
    ENSG00000228760P463792, 3MINT-64124 I2D: score=5 
    ENSG00000229524P463792, 3MINT-64124 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006888ER to Golgi vesicle-mediated transport IEA--
    GO:0006903vesicle targeting TAS9188044
    GO:0016192vesicle-mediated transport ----
    GO:0042147retrograde transport, endosome to Golgi IDA15215310

    STX5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STX5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STX5

    1 Novoseek inferred chemical compound relationship for STX5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 0 3 9325254 (2)

    Search CenterWatch for drugs/clinical trials and news about STX5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STX5 gene (2 alternative transcripts): 
    NM_001244666.1  NM_003164.4  

    Unigene Cluster for STX5:

    Syntaxin 5
    Hs.654602  [show with all ESTs]
    Unigene Representative Sequence: NM_001244666
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377897 ENST00000294179(uc001nvh.3 uc010rmj.2 uc010rmi.2)
    ENST00000394690 ENST00000492066 ENST00000491231 ENST00000431400 ENST00000488303
    ENST00000486437 ENST00000541317
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STX5
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate STX5 (see all 23):
    hsa-miR-485-5p hsa-miR-3660 hsa-miR-513a-5p hsa-miR-1271 hsa-miR-431 hsa-miR-629* hsa-miR-133a hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidSTX5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STX5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX5
    Clone
    Products:
         
    OriGene clones in human, mouse for STX5 (see all 9)
    OriGene ORF clones in mouse, rat for STX5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STX5 (NM_003164)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STX5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX5
    Sirion Biotech Customized lentivirus for stable overexpression of STX5 
                         Customized lentivirus expression plasmids for stable overexpression of STX5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STX5
    OriGene qSTAR qPCR primer pairs in human, mouse for STX5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STX5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX5

    Additional mRNA sequence: 

    AK296675.1 AK313497.1 BC002645.1 BC012137.1 BT019646.1 BT019647.1 BX537426.1 U26648.1 

    17 DOTS entries:

    DT.100810907  DT.100810899  DT.447467  DT.97848001  DT.97820918  DT.87005608  DT.100842665  DT.95341911 
    DT.120734005  DT.95254928  DT.91888121  DT.95254925  DT.100705633  DT.100810897  DT.75172632  DT.97848002 
    DT.91794017 

    24/444 AceView cDNA sequences (see all 444):

    CF242794 AI078306 AW262886 BQ944616 BM676013 BM562596 BU542585 CR603145 
    AA907437 CB051156 AA748437 CB160036 CA433470 AW263153 CR599366 AW009842 
    AI002229 CR601025 CB305786 BC006351 AA583721 CR598633 BC002645 BI757263 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for STX5 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:                                                              -           -                                 
    SP2:                                                              -           -                 -               
    SP3:                                                                                                            
    SP4:                                                                                            -               
    SP5:                                                                          -                                 


    ECgene alternative splicing isoforms for STX5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STX5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGGCAGGG
    STX5 Expression
    About this image


    See STX5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STX5

    SOURCE GeneReport for Unigene cluster: Hs.654602
        SABiosciences Custom PCR Arrays for STX5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for STX5
    OriGene qSTAR qPCR primer pairs in human, mouse for STX5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STX5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STX5 gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stx5a1 , 5 syntaxin 5A1, 5 89.86(n)1
    94.08(a)1
      19 (5.45 cM)5
    563891  NM_001167799.11  NP_001161271.11 
     87414135 
    lizard
    (Anolis carolinensis)
    Reptilia STX56
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343739.1(174552-192022)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.141902 Xenopus laevis transcribed sequence with moderate similarity more 79.88(n)    CA790267.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb81g122 wufb81g12 77.76(n)   323105  BC059605.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syx51 Syntaxin 5 56.43(n)
    54.82(a)
      34966  NM_078858.4  NP_523582.4 
    worm
    (Caenorhabditis elegans)
    Secernentea syx-51 Protein SYX-5 49.05(n)
    44.11(a)
      179611  NM_073567.5  NP_505968.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SED5(YLR026C)4
    SED51
    cis-Golgi t-SNARE syntaxin required for vesicular transport more4
    Sed5p1
    44.11(n)1
    35.69(a)1
      12(196472-195450)4
    8507131, 4  NP_013126.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SYP321 syntaxin-32 49.56(n)
    42.67(a)
      822024  NM_113342.3  NP_189078.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g01792001 hypothetical protein 48.8(n)
    42.81(a)
      4323876  NM_001048732.1  NP_001042197.1 


    ENSEMBL Gene Tree for STX5 (if available)
    TreeFam Gene Tree for STX5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/608 SNPs in STX5 are shown (see all 608)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356424
    A breast cancer sample4--see VAR_0356422 Q H mis40--------
    rs29582351,2
    H--58906208(+) AAGACA/TTTATG 2 -- int14Minor allele frequency- T:0.00NS EA 412
    rs714584381,2
    C--58906602(+) ATCTC-/AAAAAA 2 -- int11Minor allele frequency- A:0.50NA 2
    rs3715064601,2
    C--58909592(+) CGTCT-/A/AA  
            
    AAAAA
    2 -- int10--------
    rs358980941,2
    C,F--58910983(+) TAGATA/-AGAGT 2 -- int13Minor allele frequency- -:0.33NA CSA 6
    rs38337581,2
    C--58921227(+) TGGGG-/GATAATAA 4 -- int1 cds12Minor allele frequency- GAT:0.25NA 4
    rs562506211,2
    C--58925957(+) AAATA-/AATA/AATAAAT
    A
    /AATAAATAAATA
    GCACT
    4 -- int1 cds10--------
    rs108972941,2
    C,F,A,H--62494107(+) CCCTGG/AACGGT 2 -- ds500119Minor allele frequency- A:0.11NS EA NA MN WA 3584
    rs122253381,2
    C,H--62494163(+) TTGGTG/AAAGTG 2 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs112312241,2
    C,F,H--62494194(+) TCAACT/GGGAGT 2 -- ds50014Minor allele frequency- G:0.00NS EA 416

    HapMap Linkage Disequilibrium report for STX5 (62574369 - 62599560 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for STX5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509416CNV Insertion20534489
    nsv483055CNV Loss15286789
    nsv508636CNV Loss20534489
    nsv897623CNV Loss21882294
    esv991674OTHER Inversion20482838

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing STX5
    DNA2.0 Custom Variant and Variant Library Synthesis for STX5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603189    OMIM disorders: --

    5 diseases for STX5:    About MalaCards
    endometriosis    intrahepatic cholangiocarcinoma    cholangiocarcinoma    cystic fibrosis
    neuronitis


    STX5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): STX5
    Human Genome Epidemiology (HuGE) Navigator: STX5 (1 document)

    Export disorders for STX5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STX5 gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with STX5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and identification of human syntaxin 5 as a synaptobrevin/VAMP binding protein. (PubMed id 9188044)1, 2, 3, 9 Ravichandran V. and Roche P.A. (1997)
    2. Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. (PubMed id 19536132)1, 2, 9 Laufman O....Lev S. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity. (PubMed id 11959998)1, 3 Parlati F....Rothman J.E. (2002)
    5. Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs. (PubMed id 9647643)1, 9 Hay J.C....Scheller R.H. (1998)
    6. rsly1 binding to syntaxin 5 is required for endoplasmic reticulum-to-Golgi transport but does not promote SNARE motif accessibility. (PubMed id 14565970)1, 9 Williams A.L....Hay J.C. (2004)
    7. Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro. (PubMed id 9506515)1, 9 Rabouille C....Warren G. (1998)
    8. Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner. (PubMed id 18167358)1, 9 Diao A....Lowe M. (2008)
    9. Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins. (PubMed id 17389686)1, 9 Amessou M....Johannes L. (2007)
    10. Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network. (PubMed id 15215310)1, 9 Tai G.... Hong W. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6811 HGNC: 11440 AceView: STX5A Ensembl:ENSG00000162236 euGenes: HUgn6811
    ECgene: STX5 Kegg: 6811 H-InvDB: STX5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STX5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STX5 gene:
    Search GeneIP for patents involving STX5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for STX5 (Syntaxin 5)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for STX5   OriGene RNAi products in human, mouse, rat for STX5  
     OriGene qPCR primer pairs and template standards for STX5   OriGene Protein Over-expression Lysate for STX5  
     OriGene MassSpec something-or-other for STX5   OriGene clones in human, mouse for STX5  
     OriGene qSTAR qPCR primer pairs in human, mouse for STX5   OriGene Purified Protein for STX5  
     OriGene ORF clones in mouse, rat for STX5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for STX5   OriGene Custom Protein Services for STX5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STX5
     QIAGEN SeqTarget long-range PCR primers for resequencing STX5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX5
     GenScript Custom Purified and Recombinant Proteins Services for STX5 GenScript cDNA clones with any tag delivered in your preferred vector for STX5
     GenScript Custom Assay Services for STX5 GenScript Custom Superior Antibodies Services for STX5
     GenScript Custom overexpressing Cell Line Services for STX5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in STX5 promoter
     Search Chromatin IP Primers for STX5
     RT2 qPCR Primer Assay in human, mouse, rat STX5
     GNC Network for STX5
     SABiosciences Custom PCR Arrays for STX5
     Search Tocris compounds for STX5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     STX5 antibodies
     STX5 proteins
     STX5 lysates
     Antibodies for STX5
     See all of Abcam's Antibodies, Kits and Proteins for STX5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for STX5
     Antibodies for STX5
     ELISAs for STX5
     CLIAs for STX5
     Search LifeMap BioReagents cell lines for STX5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX5
     SwitchGear 3'UTR luciferase reporter plasmids for STX5
     SwitchGear Promoter luciferase reporter plasmids for STX5
     ThermoFisher Antibody for STX5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for STX5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STX5
    Customized:
     lentivirus for stable overexpression of STX5
     lentivirus expression plasmids for stable overexpression of STX5
     adenovirus for overexpression of STX5
     LSBio Antibodies in human, mouse, rat for STX5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      STX5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4