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STX5 Gene

protein-coding   GIFtS: 60
GCID: GC11M062574

Syntaxin 5

(Previous name: syntaxin 5A)
(Previous symbol: STX5A)
  See STX5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Syntaxin 51 2
STX5A1 2 3 5
Syntaxin 5A1 2
SED52
syntaxin-52

External Ids:    HGNC: 114401   Entrez Gene: 68112   Ensembl: ENSG000001622367   OMIM: 6031895   UniProtKB: Q131903   

Export aliases for STX5 gene to outside databases

Previous GC identifers: GC11M062331 GC11M058904


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STX5 Gene:
This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on
cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic
vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a
critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for
endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this
gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for STX5 Gene:
STX5 (syntaxin 5) is a protein-coding gene. Diseases associated with STX5 include endometriosis. GO annotations related to this gene include SNAP receptor activity and protein N-terminus binding.

UniProtKB/Swiss-Prot: STX5_HUMAN, Q13190
Function: Mediates endoplasmic reticulum to Golgi transport (By similarity)

Gene Wiki entry for STX5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STX5 gene promoter:
         AP-1   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTX5 promoter sequence
   Search Chromatin IP Primers for STX5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

STX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STX5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M062574:  view genomic region     (about GC identifiers)

Start:
62,574,369 bp from pter      End:
62,599,560 bp from pter
Size:
25,192 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: STX5_HUMAN, Q13190 (See protein sequence)
Recommended Name: Syntaxin-5  
Size: 355 amino acids; 39673 Da
Subunit: Part of a ternary complex containing STX5A, NSFL1C and VCP. Identified in a unique SNARE complex composed
of the Golgi SNAREs GOSR1, GOSR2, YKT6 and VTI1A (By similarity). Interacts with COG4
1 PDB 3D structure from and Proteopedia for STX5:
3EFO (3D)    
Secondary accessions: B2R8T2 Q5U0D4 Q7Z3T6 Q9BUG1
Alternative splicing, Alternative initiation: 3 isoforms:  Q13190-1   Q13190-2   Q13190-3   (Produced by alternative splicing and alternative initiation)

Explore the universe of human proteins at neXtProt for STX5: NX_Q13190

Explore proteomics data for STX5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys82, Lys148, Lys241
  • Modification sites at PhosphoSitePlus

  • See STX5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001231595.1  NP_003155.2  

    ENSEMBL proteins: 
     ENSP00000367129   ENSP00000294179   ENSP00000378182   ENSP00000434107   ENSP00000432748  
     ENSP00000414289   ENSP00000435973   ENSP00000436495   ENSP00000441428  

    STX5 Human Recombinant Protein Products:

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    Novus Biologicals STX5 Proteins
    Novus Biologicals STX5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STX5

     
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    antibodies-online proteins for STX5 (5 products) 

     
    antibodies-online peptides for STX5

    STX5 Antibody Products:

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    antibodies-online antibodies for STX5 (28 products) 

    STX5 Assay Products:

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    antibodies-online kits for STX5 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000727 T_SNARE_dom
     IPR010989 t-SNARE
     IPR006011 Syntaxin_N
     IPR006012 Syntaxin/epimorphin_CS

    Graphical View of Domain Structure for InterPro Entry Q13190

    ProtoNet protein and cluster: Q13190

    1 Blocks protein domain: IPB006011 Syntaxin

    UniProtKB/Swiss-Prot: STX5_HUMAN, Q13190
    Similarity: Belongs to the syntaxin family
    Similarity: Contains 1 t-SNARE coiled-coil homology domain


    Find genes that share domains with STX5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STX5_HUMAN, Q13190
    Function: Mediates endoplasmic reticulum to Golgi transport (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005484SNAP receptor activity IDA15215310
    GO:0005515protein binding IPI19536132
    GO:0047485protein N-terminus binding IPI19536132
         
    Find genes that share ontologies with STX5           About GenesLikeMe


    Phenotypes:
         8 GenomeRNAi human phenotypes for STX5:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella-containin  Decreased Tat-dependent transc  Decreased p24 protein expressi  Increased cell death HMECs cel 

         1 MGI phenotypic allele for Stx5a (no phenotypes)

    Find genes that share phenotypes with STX5           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STX5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STX5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STX5

    miRNA
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    miRTarBase miRNAs that target STX5:
    hsa-mir-155-5p (MIRT021024)

    Block miRNA regulation of human, mouse, rat STX5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STX5 (see all 23):
    hsa-miR-485-5p hsa-miR-3660 hsa-miR-513a-5p hsa-miR-1271 hsa-miR-431 hsa-miR-629* hsa-miR-133a hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidSTX5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STX5
    Predesigned siRNA for gene silencing in human, mouse, rat STX5

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: STX5 (NM_003164)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STX5
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12209) for STX5 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STX5_HUMAN, Q13190: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type IV membrane
    protein (By similarity). Golgi apparatus membrane (By similarity). Note=Localizes throughout the Golgi apparatus,
    but most abundant in the cis-most cisternae (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus4
    cytosol3
    endoplasmic reticulum2
    plasma membrane2
    endosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IDA--

    Find genes that share ontologies with STX5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STX5 About    
    See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    2Transmission across Chemical Synapses
    Neuronal System0.68
    3Clathrin dependent protein traffic
    Transport Clathrin coated vesicle cycle0.66
    4Disease
    Disease


    Find genes that share SuperPaths with STX5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STX5
        Epithelial Tight Junctions

    1 GeneGo (Thomson Reuters) Pathway for STX5
        Transport Clathrin-coated vesicle cycle

    1 PharmGKB Pathway for STX5
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    1 Kegg Pathway  (Kegg details for STX5):
        SNARE interactions in vesicular transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STX5
    Interactions:

        GeneGlobe Interaction Network for STX5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STX5 (Q131901, 2, 3 ENSP000002941794) via UniProtKB, MINT, STRING, and/or I2D (see all 168)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COG4Q9H9E31, 2, 3, ENSP000003157754EBI-714206,EBI-368382 MINT-7296969 MINT-7296916 I2D: score=1 STRING: ENSP00000315775
    BAG6P463792, 3MINT-64124 I2D: score=5 
    ENSG00000096155P463792, 3MINT-64124 I2D: score=5 
    ENSG00000227761P463792, 3MINT-64124 I2D: score=5 
    ENSG00000228760P463792, 3MINT-64124 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006888ER to Golgi vesicle-mediated transport IEA--
    GO:0006903vesicle targeting TAS9188044
    GO:0016192vesicle-mediated transport ----
    GO:0042147retrograde transport, endosome to Golgi IDA15215310

    Find genes that share ontologies with STX5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STX5

    1 Novoseek inferred chemical compound relationship for STX5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 0 3 9325254 (2)



    Find genes that share compounds with STX5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STX5 gene (2 alternative transcripts): 
    NM_001244666.1  NM_003164.4  

    Unigene Cluster for STX5:

    Syntaxin 5
    Hs.654602  [show with all ESTs]
    Unigene Representative Sequence: NM_001244666
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377897 ENST00000294179(uc001nvh.3 uc010rmj.2 uc010rmi.2)
    ENST00000394690 ENST00000492066 ENST00000491231 ENST00000431400 ENST00000488303
    ENST00000486437 ENST00000541317
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate STX5 (see all 23):
    hsa-miR-485-5p hsa-miR-3660 hsa-miR-513a-5p hsa-miR-1271 hsa-miR-431 hsa-miR-629* hsa-miR-133a hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidSTX5 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: STX5 (NM_003164)
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    Primer
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12209) for STX5 

    Additional mRNA sequence: 

    AK296675.1 AK313497.1 BC002645.1 BC012137.1 BT019646.1 BT019647.1 BX537426.1 U26648.1 

    17 DOTS entries:

    DT.100810907  DT.100810899  DT.447467  DT.97848001  DT.97820918  DT.87005608  DT.100842665  DT.95341911 
    DT.120734005  DT.95254928  DT.91888121  DT.95254925  DT.100705633  DT.100810897  DT.75172632  DT.97848002 
    DT.91794017 

    Selected AceView cDNA sequences (see all 444):

    BQ218604 BI835195 BM725720 AA811873 BG025195 BM789916 BM671172 R63059 
    BQ231251 BC002645 CR617230 CR601025 CR606940 BX096023 BM834292 AA583721 
    CR596173 CR590111 BX281004 BU740579 CR598903 CF242794 AI078306 AW262886 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STX5 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:                                                              -           -                                 
    SP2:                                                              -           -                 -               
    SP3:                                                                                                            
    SP4:                                                                                            -               
    SP5:                                                                          -                                 


    ECgene alternative splicing isoforms for STX5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STX5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGGCAGGG
    STX5 Expression
    About this image

    STX5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STX5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654602
        Custom PCR Arrays for STX5
    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STX5 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stx5a1 , 5 syntaxin 5A1, 5 89.45(n)1
    93.79(a)1
      19 (5.45 cM)5
    563891  NM_019829.41  NP_062803.41 
     87414135 
    lizard
    (Anolis carolinensis)
    Reptilia STX56
    syntaxin 5
    77(a)
    1 ↔ 1
    GL343739.1(174552-192022)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.141902 Xenopus laevis transcribed sequence with moderate similarity more 79.88(n)    CA790267.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb81g122 wufb81g12 77.76(n)   323105  BC059605.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syx51 Syntaxin 5 59.91(n)
    58.36(a)
      34966  NM_078858.5  NP_523582.4 
    worm
    (Caenorhabditis elegans)
    Secernentea syx-51 syx-5 48.4(n)
    43.42(a)
      179611  NM_073567.6  NP_505968.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SED5(YLR026C)4
    SED51
    cis-Golgi t-SNARE syntaxin required for vesicular transport more4
    SED51
    43.72(n)1
    38.04(a)1
      12(196472-195450)4
    8507131, 4  NP_013126.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SYP321 SYP32 48.53(n)
    41.7(a)
      822024  NM_001203032.1  NP_001189961.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01792001 Os01g0179200 48.75(n)
    43.42(a)
      4323876  NM_001048732.1  NP_001042197.1 


    ENSEMBL Gene Tree for STX5 (if available)
    TreeFam Gene Tree for STX5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STX5 (see all 608)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356424
    A breast cancer sample4--see VAR_0356422 Q H mis40--------
    rs29582351,2
    H--58906208(+) AAGACA/TTTATG 2 -- int14Minor allele frequency- T:0.00NS EA 412
    rs714584381,2
    C--58906602(+) ATCTC-/AAAAAA 2 -- int11Minor allele frequency- A:0.50NA 2
    rs3715064601,2
    C--58909592(+) CGTCT-/A/AA  
            
    AAAAA
    2 -- int10--------
    rs358980941,2
    C,F--58910983(+) TAGATA/-AGAGT 2 -- int13Minor allele frequency- -:0.33NA CSA 6
    rs38337581,2
    C--58921227(+) TGGGG-/GATAATAA 4 -- int1 cds12Minor allele frequency- GAT:0.25NA 4
    rs562506211,2
    C--58925957(+) AAATA-/AATA/AATAAAT
    A
    /AATAAATAAATA
    GCACT
    4 -- int1 cds10--------
    rs108972941,2
    C,F,A,H--62494107(+) CCCTGG/AACGGT 2 -- ds500119Minor allele frequency- A:0.11NS EA NA MN WA 3584
    rs122253381,2
    C,H--62494163(+) TTGGTG/AAAGTG 2 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs112312241,2
    C,F,H--62494194(+) TCAACT/GGGAGT 2 -- ds50014Minor allele frequency- G:0.00NS EA 416

    HapMap Linkage Disequilibrium report for STX5 (62574369 - 62599560 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for STX5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509416CNV Insertion20534489
    nsv483055CNV Loss15286789
    nsv508636CNV Loss20534489
    nsv897623CNV Loss21882294
    esv991674OTHER Inversion20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STX5
    DNA2.0 Custom Variant and Variant Library Synthesis for STX5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603189    OMIM disorders: --

    1 disease for STX5:    
    About MalaCards
    endometriosis


    Find genes that share disorders with STX5           About GenesLikeMe

    Genetic Association Database (GAD): STX5
    Human Genome Epidemiology (HuGE) Navigator: STX5 (1 document)

    Export disorders for STX5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STX5 gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with STX5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and identification of human syntaxin 5 as a synaptobrevin/VAMP binding protein. (PubMed id 9188044)1, 2, 3, 9 Ravichandran V. and Roche P.A. (J. Mol. Neurosci. 1997)
    2. Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. (PubMed id 19536132)1, 2, 9 Laufman O.... Lev S. (EMBO J. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity. (PubMed id 11959998)1, 3 Parlati F....Rothman J.E. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs. (PubMed id 9647643)1, 9 Hay J.C....Scheller R.H. (J. Cell Biol. 1998)
    6. rsly1 binding to syntaxin 5 is required for endoplasmic reticulum-to-Golgi transport but does not promote SNARE motif accessibility. (PubMed id 14565970)1, 9 Williams A.L....Hay J.C. (Mol. Biol. Cell 2004)
    7. Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro. (PubMed id 9506515)1, 9 Rabouille C....Warren G. (Cell 1998)
    8. Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner. (PubMed id 18167358)1, 9 Diao A....Lowe M. (J. Biol. Chem. 2008)
    9. Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins. (PubMed id 17389686)1, 9 Amessou M....Johannes L. (J. Cell. Sci. 2007)
    10. Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network. (PubMed id 15215310)1, 9 Tai G.... Hong W. (Mol. Biol. Cell 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6811 HGNC: 11440 AceView: STX5A Ensembl:ENSG00000162236 euGenes: HUgn6811
    ECgene: STX5 Kegg: 6811 H-InvDB: STX5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STX5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STX5 gene:
    Search GeneIP for patents involving STX5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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