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Aliases for STX5 Gene

Aliases for STX5 Gene

  • Syntaxin 5 2 3
  • STX5A 3 4 6
  • Syntaxin 5A 2 3
  • Syntaxin-5 3
  • SED5 3

External Ids for STX5 Gene

Previous Symbols for STX5 Gene

  • STX5A

Summaries for STX5 Gene

Entrez Gene Summary for STX5 Gene

  • This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for STX5 Gene

STX5 (Syntaxin 5) is a Protein Coding gene. Diseases associated with STX5 include endometriosis. Among its related pathways are Disease and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include protein N-terminus binding and SNAP receptor activity.

UniProtKB/Swiss-Prot for STX5 Gene

  • Mediates endoplasmic reticulum to Golgi transport.

Gene Wiki entry for STX5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX5 Gene

Genomics for STX5 Gene

Genomic Location for STX5 Gene

Start:
62,806,860 bp from pter
End:
62,832,091 bp from pter
Size:
25,232 bases
Orientation:
Minus strand

Genomic View for STX5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX5 Gene

Regulatory Elements for STX5 Gene

Transcription factor binding sites by QIAGEN in the STX5 gene promoter:

Proteins for STX5 Gene

  • Protein details for STX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13190-STX5_HUMAN
    Recommended name:
    Syntaxin-5
    Protein Accession:
    Q13190
    Secondary Accessions:
    • B2R8T2
    • F8W8Q9
    • Q5U0D4
    • Q7Z3T6
    • Q9BUG1

    Protein attributes for STX5 Gene

    Size:
    355 amino acids
    Molecular mass:
    39673 Da
    Quaternary structure:
    • Part of a ternary complex containing STX5A, NSFL1C and VCP. Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2, YKT6 and VTI1A (By similarity). Interacts with COG4.

    Three dimensional structures from OCA and Proteopedia for STX5 Gene

    Alternative splice isoforms for STX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX5 Gene

Proteomics data for STX5 Gene at MOPED

Post-translational modifications for STX5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys82, Lys148, and Lys241

No data available for DME Specific Peptides for STX5 Gene

Domains for STX5 Gene

Protein Domains for STX5 Gene

UniProtKB/Swiss-Prot:

STX5_HUMAN
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.:
    • Q13190
Family:
  • Belongs to the syntaxin family.:
    • Q13190
genes like me logo Genes that share domains with STX5: view

No data available for Gene Families for STX5 Gene

Function for STX5 Gene

Molecular function for STX5 Gene

UniProtKB/Swiss-Prot Function: Mediates endoplasmic reticulum to Golgi transport.

Gene Ontology (GO) - Molecular Function for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IDA 15215310
GO:0005515 protein binding IPI 18167358
GO:0047485 protein N-terminus binding IPI 19536132
genes like me logo Genes that share ontologies with STX5: view
genes like me logo Genes that share phenotypes with STX5: view

miRNA for STX5 Gene

miRTarBase miRNAs that target STX5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for STX5 Gene

Localization for STX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX5 Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type IV membrane protein. Golgi apparatus membrane. Note=Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX5 Gene COMPARTMENTS Subcellular localization image for STX5 gene
Compartment Confidence
golgi apparatus 5
nucleus 4
cytosol 3
endoplasmic reticulum 2
plasma membrane 2
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with STX5: view

Pathways for STX5 Gene

genes like me logo Genes that share pathways with STX5: view

Pathways by source for STX5 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for STX5 Gene
1 Qiagen pathway for STX5 Gene
2 Reactome pathways for STX5 Gene
1 KEGG pathway for STX5 Gene

Gene Ontology (GO) - Biological Process for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0006903 vesicle targeting --
GO:0006906 vesicle fusion IBA --
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with STX5: view

Compounds for STX5 Gene

(1) Novoseek inferred chemical compound relationships for STX5 Gene

Compound -log(P) Hits PubMed IDs
atp 0 2
genes like me logo Genes that share compounds with STX5: view

Transcripts for STX5 Gene

Unigene Clusters for STX5 Gene

Syntaxin 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STX5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - -
SP2: - - -
SP3:
SP4: -
SP5: -
SP6:

Relevant External Links for STX5 Gene

GeneLoc Exon Structure for
STX5
ECgene alternative splicing isoforms for
STX5

Expression for STX5 Gene

mRNA expression in normal human tissues for STX5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX5 Gene

SOURCE GeneReport for Unigene cluster for STX5 Gene Hs.654602

genes like me logo Genes that share expressions with STX5: view

Orthologs for STX5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STX5 36
  • 99.22 (n)
  • 99.67 (a)
STX5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STX5 36
  • 94.08 (n)
  • 98.59 (a)
STX5 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STX5 36
  • 93.52 (n)
  • 98.03 (a)
STX5 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stx5a 36
  • 89.45 (n)
  • 93.79 (a)
Stx5a 16
Stx5a 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STX5 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX5 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stx5 36
  • 89.74 (n)
  • 94.67 (a)
lizard
(Anolis carolinensis)
Reptilia STX5 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14190 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1892 36
stx5 36
  • 72.72 (n)
  • 83.99 (a)
zebrafish
(Danio rerio)
Actinopterygii stx5a 36
  • 74.59 (n)
  • 80.5 (a)
stx5a 37
  • 80 (a)
OneToMany
stx5al 37
  • 66 (a)
OneToMany
wufb81g12 36
fruit fly
(Drosophila melanogaster)
Insecta Syx5 36
  • 59.91 (n)
  • 58.36 (a)
Syx5 37
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea syx-5 36
  • 48.4 (n)
  • 43.42 (a)
syx-5 37
  • 33 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR210C 36
  • 47.77 (n)
  • 40.14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SED5 36
  • 43.72 (n)
  • 38.04 (a)
SED5 37
  • 30 (a)
OneToOne
SED5 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17798g 36
  • 45.49 (n)
  • 35.38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SYP32 36
  • 48.53 (n)
  • 41.7 (a)
rice
(Oryza sativa)
Liliopsida Os01g0179200 36
  • 48.75 (n)
  • 43.42 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01907 36
  • 51.03 (n)
  • 46.91 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sed5 36
  • 49.23 (n)
  • 41.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2930 37
  • 49 (a)
OneToOne
Species with no ortholog for STX5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX5 Gene

ENSEMBL:
Gene Tree for STX5 (if available)
TreeFam:
Gene Tree for STX5 (if available)

Paralogs for STX5 Gene

No data available for Paralogs for STX5 Gene

Variants for STX5 Gene

Sequence variations from dbSNP and Humsavar for STX5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs482331 -- 62,827,858(-) TTAAG(G/T)AACTC intron-variant
rs497980 -- 62,814,543(-) cggaa(A/G)ttggg intron-variant
rs508181 -- 62,817,140(+) CCAGG(C/G)TGGTC intron-variant
rs524034 -- 62,811,766(-) ctcat(C/G)cctgt intron-variant
rs631987 -- 62,811,755(+) gtgct(A/G)ggatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STX5 Gene

Variant ID Type Subtype PubMed ID
nsv897623 CNV Loss 21882294
nsv483055 CNV Loss 15286789
nsv508636 CNV Loss 20534489
nsv509416 CNV Insertion 20534489
esv991674 OTHER Inversion 20482838

Relevant External Links for STX5 Gene

HapMap Linkage Disequilibrium report
STX5

Disorders for STX5 Gene

(1) MalaCards Diseases for STX5 Gene

Search for STX5 Gene in MalaCards »

Relevant External Links for STX5

Genetic Association Database (GAD)
STX5
Human Genome Epidemiology (HuGE) Navigator
STX5
genes like me logo Genes that share disorders with STX5: view

No data available for UniProtKB/Swiss-Prot for STX5 Gene

Publications for STX5 Gene

  1. Cloning and identification of human syntaxin 5 as a synaptobrevin/VAMP binding protein. (PMID: 9188044) Ravichandran V. … Roche P.A. (J. Mol. Neurosci. 1997) 2 3 4 23
  2. Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. (PMID: 19536132) Laufman O. … Lev S. (EMBO J. 2009) 3 4 23
  3. Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production. (PMID: 15109302) Suga K. … Akagawa K. (Biochem. J. 2004) 3 23
  4. Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network. (PMID: 15215310) Tai G. … Hong W. (Mol. Biol. Cell 2004) 3 23
  5. Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins. (PMID: 17389686) Amessou M. … Johannes L. (J. Cell. Sci. 2007) 3 23

Products for STX5 Gene

Sources for STX5 Gene

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