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Aliases for STX5 Gene

Aliases for STX5 Gene

  • Syntaxin 5 2 3 5
  • Syntaxin 5A 2 3
  • STX5A 3 4
  • Syntaxin-5 3
  • SED5 3

External Ids for STX5 Gene

Previous HGNC Symbols for STX5 Gene

  • STX5A

Previous GeneCards Identifiers for STX5 Gene

  • GC11M062331
  • GC11M062574
  • GC11M058904

Summaries for STX5 Gene

Entrez Gene Summary for STX5 Gene

  • This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for STX5 Gene

STX5 (Syntaxin 5) is a Protein Coding gene. Diseases associated with STX5 include Endometriosis. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include protein N-terminus binding and SNAP receptor activity.

UniProtKB/Swiss-Prot for STX5 Gene

  • Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.

Gene Wiki entry for STX5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX5 Gene

Genomics for STX5 Gene

Regulatory Elements for STX5 Gene

Enhancers for STX5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F062669 0.2 ENCODE 33.4 +160.6 160603 4.2 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 DEK EML3 STX5 METTL12 TAF6L LOC105369332 INTS5 MTA2 NXF1 TTC9C SNHG1
GH11F062041 1.4 Ensembl ENCODE 31.2 +786.7 786664 8.1 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 SP3 NFYC MEF2D METTL12 INTS5 SNHG1 NXF1 TMEM138 LOC105369332 VPS37C EML3 MTA2 TAF6L
GH11F062651 0.2 ENCODE 23.5 +179.3 179261 2.3 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 EML3 METTL12 INTS5 MTA2 NXF1 STX5 SNHG1 TAF6L LOC105369332 MIR6748
GH11F062852 1.3 FANTOM5 ENCODE 23.3 -23.7 -23747 5.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC METTL12 INTS5 NXF1 SNHG1 UBXN1 MTA2 EML3 MIR6748 LOC105369332 STX5
GH11F062838 0.2 ENCODE 21.6 -8.8 -8755 4.8 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 METTL12 UBXN1 LRRN4CL NXF1 TAF6L INTS5 IMMP1LP1 SNHG1 TTC9C STX5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around STX5 on UCSC Golden Path with GeneCards custom track

Promoters for STX5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000563379 291 2801 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 SLC30A9

Genomic Location for STX5 Gene

Chromosome:
11
Start:
62,806,860 bp from pter
End:
62,832,091 bp from pter
Size:
25,232 bases
Orientation:
Minus strand

Genomic View for STX5 Gene

Genes around STX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX5 Gene

Proteins for STX5 Gene

  • Protein details for STX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13190-STX5_HUMAN
    Recommended name:
    Syntaxin-5
    Protein Accession:
    Q13190
    Secondary Accessions:
    • B2R8T2
    • F8W8Q9
    • Q5U0D4
    • Q7Z3T6
    • Q9BUG1

    Protein attributes for STX5 Gene

    Size:
    355 amino acids
    Molecular mass:
    39673 Da
    Quaternary structure:
    • Part of a ternary complex containing STX5A, NSFL1C and VCP (By similarity). Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2, YKT6 and VTI1A (By similarity). Interacts with COG4 (PubMed:19536132). Interacts with GM130/GOLGA2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for STX5 Gene

    Alternative splice isoforms for STX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX5 Gene

Post-translational modifications for STX5 Gene

  • Ubiquitination at Lys 82, Lys 148, and Lys 241
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STX5 (STX5)

No data available for DME Specific Peptides for STX5 Gene

Domains & Families for STX5 Gene

Gene Families for STX5 Gene

Protein Domains for STX5 Gene

Suggested Antigen Peptide Sequences for STX5 Gene

Graphical View of Domain Structure for InterPro Entry

Q13190

UniProtKB/Swiss-Prot:

STX5_HUMAN :
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX5: view

Function for STX5 Gene

Molecular function for STX5 Gene

UniProtKB/Swiss-Prot Function:
Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.

Gene Ontology (GO) - Molecular Function for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IDA 15215310
GO:0005515 protein binding IPI 18167358
GO:0047485 protein N-terminus binding IPI 19536132
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with STX5: view
genes like me logo Genes that share phenotypes with STX5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STX5

miRNA for STX5 Gene

miRTarBase miRNAs that target STX5

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STX5 Gene

Localization for STX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX5 Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type IV membrane protein. Golgi apparatus membrane. Note=Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae. {ECO:0000250 UniProtKB:Q08851}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX5 Gene COMPARTMENTS Subcellular localization image for STX5 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
nucleus 5
cytosol 3
plasma membrane 3
endosome 2
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IEA,IDA 9464276
genes like me logo Genes that share ontologies with STX5: view

Pathways & Interactions for STX5 Gene

genes like me logo Genes that share pathways with STX5: view

Gene Ontology (GO) - Biological Process for STX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IBA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006906 vesicle fusion IBA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with STX5: view

No data available for SIGNOR curated interactions for STX5 Gene

Drugs & Compounds for STX5 Gene

(1) Drugs for STX5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with STX5: view

Transcripts for STX5 Gene

Unigene Clusters for STX5 Gene

Syntaxin 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - -
SP2: - - -
SP3:
SP4: -
SP5: -
SP6:

Relevant External Links for STX5 Gene

GeneLoc Exon Structure for
STX5
ECgene alternative splicing isoforms for
STX5

Expression for STX5 Gene

mRNA expression in normal human tissues for STX5 Gene

Protein differential expression in normal tissues from HIPED for STX5 Gene

This gene is overexpressed in Cervix (13.6) and Peripheral blood mononuclear cells (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STX5 Gene



Protein tissue co-expression partners for STX5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STX5 Gene:

STX5

SOURCE GeneReport for Unigene cluster for STX5 Gene:

Hs.654602
genes like me logo Genes that share expression patterns with STX5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STX5 Gene

Orthologs for STX5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STX5 34 35
  • 99.22 (n)
cow
(Bos Taurus)
Mammalia STX5 34 35
  • 94.08 (n)
dog
(Canis familiaris)
Mammalia STX5 34 35
  • 93.52 (n)
rat
(Rattus norvegicus)
Mammalia Stx5 34
  • 89.74 (n)
mouse
(Mus musculus)
Mammalia Stx5a 34 16 35
  • 89.45 (n)
oppossum
(Monodelphis domestica)
Mammalia STX5 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX5 35
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX5 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stx5 34
  • 72.72 (n)
Str.1892 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14190 34
zebrafish
(Danio rerio)
Actinopterygii stx5a 34 35
  • 74.59 (n)
stx5al 35
  • 66 (a)
OneToMany
wufb81g12 34
fruit fly
(Drosophila melanogaster)
Insecta Syx5 34 35
  • 59.91 (n)
worm
(Caenorhabditis elegans)
Secernentea syx-5 34 35
  • 48.4 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR210C 34
  • 47.77 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17798g 34
  • 45.49 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SED5 34 35 37
  • 43.72 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SYP32 34
  • 48.53 (n)
rice
(Oryza sativa)
Liliopsida Os01g0179200 34
  • 48.75 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01907 34
  • 51.03 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sed5 34
  • 49.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2930 35
  • 49 (a)
OneToOne
Species where no ortholog for STX5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX5 Gene

ENSEMBL:
Gene Tree for STX5 (if available)
TreeFam:
Gene Tree for STX5 (if available)

Paralogs for STX5 Gene

No data available for Paralogs for STX5 Gene

Variants for STX5 Gene

Sequence variations from dbSNP and Humsavar for STX5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_035642 A breast cancer sample
rs10431142 -- 62,830,672(+) TAGAA(G/T)TATAT intron-variant, upstream-variant-2KB
rs10431143 -- 62,830,757(+) TGCAG(C/G)CAAGT intron-variant, upstream-variant-2KB
rs10431144 -- 62,830,824(+) AAAAA(A/G)AAGTC intron-variant, upstream-variant-2KB
rs10484 -- 62,807,115(-) AGGGA(G/T)ATGAT upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for STX5 Gene

Variant ID Type Subtype PubMed ID
esv991674 OTHER inversion 20482838
nsv1159903 CNV duplication 26073780
nsv508636 CNV deletion 20534489
nsv509416 CNV insertion 20534489

Variation tolerance for STX5 Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STX5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STX5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX5 Gene

Disorders for STX5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STX5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
endometriosis
- elite association - COSMIC cancer census association via MalaCards
Search STX5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STX5

Genetic Association Database (GAD)
STX5
Human Genome Epidemiology (HuGE) Navigator
STX5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STX5
genes like me logo Genes that share disorders with STX5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STX5 Gene

Publications for STX5 Gene

  1. Cloning and identification of human syntaxin 5 as a synaptobrevin/VAMP binding protein. (PMID: 9188044) Ravichandran V. … Roche P.A. (J. Mol. Neurosci. 1997) 2 3 4 22 64
  2. Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. (PMID: 19536132) Laufman O. … Lev S. (EMBO J. 2009) 3 4 22 64
  3. Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner. (PMID: 18167358) Diao A. … Lowe M. (J. Biol. Chem. 2008) 3 22 64
  4. Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins. (PMID: 17389686) Amessou M. … Johannes L. (J. Cell. Sci. 2007) 3 22 64
  5. rsly1 binding to syntaxin 5 is required for endoplasmic reticulum-to-Golgi transport but does not promote SNARE motif accessibility. (PMID: 14565970) Williams A.L. … Hay J.C. (Mol. Biol. Cell 2004) 3 22 64

Products for STX5 Gene

Sources for STX5 Gene

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