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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STX4 Gene

protein-coding   GIFtS: 61
GCID: GC16P031044

syntaxin 4

(Previous name: syntaxin 4A (placental) )
(Previous symbol: STX4A)
 Explore 17 diseases affiliated with
STX4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STX4    

Aliases
for STX4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Syntaxin 41 2
STX4A1 2 3 5
P35-21
Syntaxin 4A (Placental)1 2
Renal Carcinoma Antigen NY-REN-312 3
Syntaxin-41

External Ids:    HGNC: 114391   Entrez Gene: 68102   Ensembl: ENSG000001034967   OMIM: 1865915   UniProtKB: Q128463   

Export aliases for STX4 gene to outside databases

Previous GC identifers: GC16P030953 GC16P028606


Summaries
for STX4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: STX4_HUMAN, Q12846
Function: Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of
SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in
docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May
also play a role in docking of synaptic vesicles at presynaptic active zones

Gene Wiki entry for STX4


Genomic Views
for STX4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STX4 gene promoter:
         E2F-4   E2F-3a   E2F-5   Tal-1   NCX/Ncx   E2F-2   E47   FOXI1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STX4 promoter sequence
   Search SABiosciences Chromatin IP Primers for STX4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

STX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STX4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031044:  view genomic region     (about GC identifiers)

Start:
 31,044,210 bp from pter      End:
 31,054,296 bp from pter
Size:
 10,087 bases      Orientation:
 plus strand

Proteins
for STX4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STX4_HUMAN, Q12846 (See protein sequence)
Recommended Name: Syntaxin-4  
Size: 297 amino acids; 34180 Da
Subunit: Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal
exocytosis. Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with
VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C-terminus) with CENPF. Interacts with
DOC2B. Interacts with STXBP6. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with
STXBP4; excludes interaction with VAMP2 (By similarity)
Subcellular location: Cell membrane; Single-pass type IV membrane protein (Potential)
Secondary accessions: Q15525 Q6FHE8

Explore the universe of human proteins at neXtProt for STX4: NX_Q12846

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q12846

    • STX4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001259024.1  NP_001259025.1  NP_004595.2  

    ENSEMBL proteins: 
     ENSP00000390788   ENSP00000378447   ENSP00000317714   ENSP00000454419   ENSP00000454841  
    Reactome Protein details: Q12846
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for STX4 (Syntaxin 4)
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    OriGene Protein Over-expression Lysate: STX4
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    Novus Biologicals STX4 Proteins
    Novus Biologicals STX4 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for STX4
    Uscn Proteins for STX4

    Gene Ontology (GO): 5/17 cellular component terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005773vacuole TAS16339081
    GO:0005802trans-Golgi network IEA--
    GO:0005829cytosol TAS--


    STX4 for ontologies           About GeneDecksing



    STX4 Antibody Products: 
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    Uscn Antibodies for STX4
    ThermoFisher Antibodies for STX4

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    GenScript Custom Assay Services for STX4
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    Uscn ELISAs and CLIAs for STX4

    Protein Domains /
    Families
    for STX4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STX4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000727 T_SNARE_dom
     IPR010989 t-SNARE
     IPR006011 Syntaxin_N
     IPR006012 Syntaxin/epimorphin_CS

    Graphical View of Domain Structure for InterPro Entry Q12846

    ProtoNet protein and cluster: Q12846

    1 Blocks protein family: IPB006011 Syntaxin

    UniProtKB/Swiss-Prot: STX4_HUMAN, Q12846
    Similarity: Belongs to the syntaxin family
    Similarity: Contains 1 t-SNARE coiled-coil homology domain


    Function
    for STX4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STX4_HUMAN, Q12846
    Function: Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of
    SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in
    docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May
    also play a role in docking of synaptic vesicles at presynaptic active zones

    miRNA
    Products:            		 OriGene 3'-UTR Clone: STX4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STX4
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate STX4:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-3907
    SwitchGear 3'UTR luciferase reporter plasmid: STX4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STX4 (see all 4)
    OriGene shRNA RFP: STX4
    OriGene siRNA: STX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for STX4

    Clone
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    GenScript: all cDNA clones in your preferred vector: STX4 (NM_004604)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX4 

    Cell Line
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    Search LifeMap BioReagents cell lines for STX4

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding IEA--
    GO:0005484SNAP receptor activity IEA--
    GO:0005515protein binding IPI16189514
    GO:0017137Rab GTPase binding ----
    GO:0030507spectrin binding ----


    STX4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for STX4:
     Increased circadian rhythm amp 

    Animal Models:
         Mouse knock-out Stx4atm1Jepn for STX4
         3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Stx4a):
     hematopoietic system  homeostasis/metabolism  mortality/aging 

    STX4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for STX4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clathrin derived vesicle budding
    		Clathrin derived vesicle budding1.00
    		trans-Golgi Network Vesicle Budding1.00
    2Botulinum neurotoxicity
    		Botulinum neurotoxicity1.00
    		Proteolytic cleavage of SNARE complex proteins0.89
    3Membrane Trafficking
    		Membrane Trafficking1.00
    		Translocation of GLUT4 to the Plasma Membrane0.32
    4Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    		Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics1.00
    		SNARE interactions in vesicular transport0.40
    5Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for STX4 
        Insulin Signaling
    Stabilization and expansion of the E-cadherin adherens junction
    Insulin-mediated glucose transport

    5/13        Reactome Pathways for STX4 (see all 13)
        Hemostasis
    Proteolytic cleavage of SNARE complex proteins
    Membrane Trafficking
    Clathrin derived vesicle budding
    Translocation of GLUT4 to the Plasma Membrane

    1 PharmGKB Pathway for STX4
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    2         Kegg Pathways  (Kegg details for STX4):
        SNARE interactions in vesicular transport
    Vasopressin-regulated water reabsorption


    STX4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STX4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/82 Interacting proteins for STX4 (Q128461, 2, 3 ENSP000003177144) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAPAP549201, 2, 3, ENSP000002633544EBI-744942,EBI-749652 MINT-68367 I2D: score=6 STRING: ENSP00000263354
    VAMP4O753792, 3, ENSP000002361924MINT-66593 I2D: score=5 STRING: ENSP00000236192
    VAMP3Q158363, ENSP000000546664I2D: score=4 STRING: ENSP00000054666
    STXBP3O001863, ENSP000003590254I2D: score=3 STRING: ENSP00000359025
    STXBP4Q6ZWJ13, ENSP000003655304I2D: score=2 STRING: ENSP00000365530
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly ----
    GO:0006836neurotransmitter transport IEA--
    GO:0006886intracellular protein transport IEA--
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0006944cellular membrane fusion ----


    STX4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for STX4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STX4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STX4
    8 Novoseek chemical compound relationships for STX4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurotoxin c 84.7 2 17544372 (1), 10428873 (1)
    n-ethylmaleimide 44.5 1 11029050 (1)
    glucose 41.8 11 10394363 (2), 17001002 (1), 20053958 (1), 16516346 (1) (see all 9)
    cholesterol 0 1 16339081 (1)
    sucrose 0 1 12376543 (1)
    lipid 0 3 16513632 (2), 12376543 (1)
    calcium 0 5 14993220 (3), 9930733 (1), 9891020 (1)
    tyrosine 0 3 17916632 (2), 18541526 (1)

    1 PharmGKB related drug/compound annotation for STX4 gene
    Drug/compound PharmGKB Annotation
    warfarinCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about STX4 

    Transcripts
    for STX4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STX4 gene (3 alternative transcripts): 
    NM_001272095.1  NM_001272096.1  NM_004604.4  

    Unigene Cluster for STX4:

    Syntaxin 4
    Hs.83734  [show with all ESTs]
    Unigene Representative Sequence: AF318489
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457779 ENST00000493902 ENST00000394998(uc002eak.3) ENST00000313843(uc002eal.3 uc002eam.3)
    ENST00000487411 ENST00000460668 ENST00000496977 ENST00000566353 ENST00000461455
    ENST00000565483 ENST00000478150 ENST00000486660 ENST00000475862 ENST00000468583
    ENST00000503629(uc002ean.1) ENST00000564368

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STX4
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate STX4:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-3907
    SwitchGear 3'UTR luciferase reporter plasmid: STX4 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF026007.1 AF318489.1 AJ000541.1 AK091833.1 AK296652.1 AK315716.1 BC002436.2 BT007326.1 
    CR541806.1 U07158.1 X85784.1 

    16 DOTS entries:

    DT.455422  DT.95261426  DT.92438412  DT.95261394  DT.97845234  DT.40296648  DT.100820929  DT.92438408 
    DT.92438413  DT.91906619  DT.120728494  DT.120728498  DT.120728520  DT.95261364  DT.95261414  DT.427395 

    24/211 AceView cDNA sequences (see all 211):

    CA411628 CF272262 CR593917 AI078063 BU903021 CA941781 BM704147 CA398087 
    BM974885 BG113381 AV694359 BQ935825 CD108719 CR590461 BI858588 BQ775458 
    BU626787 BU620829 BM825111 AI887359 BM694677 BI222850 AW474710 AI610341 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for STX4 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^
    SP1:                    -     -     -     -                                         -     -           -                             -                       -   
    SP2:                                                  -                             -     -           -                             -                       -   
    SP3:                                                  -                             -     -           -                             -                           
    SP4:                    -     -     -     -           -                             -     -                                                                     
    SP5:                                                                                -     -           -                                                         

    ExUns: 15
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for STX4

    Expression
    for STX4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGGCCTCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See STX4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STX4

    SOURCE GeneReport for Unigene cluster: Hs.83734

    UniProtKB/Swiss-Prot: STX4_HUMAN, Q12846
    Tissue specificity: Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils
    increases with differentiation

        SABiosciences Expression via Pathway-Focused PCR Array including STX4: 
              Diabetes in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX4

    Orthologs
    for STX4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STX4 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia STX46
    		 --
    		 64(a)
    		 1 ↔ 1
    		 GL343220.1(2063546-2078295)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.43722 Transcribed sequence with weak similarity to protein more 77.26(n)    CF220619.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc562722 similar to syntaxin 4A (placental) 71.92(n)   393190  AY394950.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 26(a)
    		 1 → many
    		 Group3.19(21522-22264)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SYP1316
    SYP1236
    (see all 9)    		 syntaxin-123
    (see all 9)    		 20(a)
    19(a)
    (see all 9)    		 many ↔ many
    many ↔ many
    (see all 9)    		 3(969107-971460)
    4(1466336-1467750)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 7)    		 syntaxin-related protein, putative, expressed
    (see all 7)    		 20(a)
    20(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 7(3445344-3449354)
    2(6158238-6159991)


    ENSEMBL Gene Tree for STX4 (if available)
    TreeFam Gene Tree for STX4 (if available) 

    Paralogs
    for STX4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STX4 gene
    STX22  STX1A2  STX112  STX1B2  STX32  STX192  
    10 SIMAP similar genes for STX4 using alignment to 4 protein entries:     STX4_HUMAN (see all proteins):
    STX4A    DKFZp686L1857    STX2    stx1c    STX3    STX1B
    STX3A    STX1A    STX19    STX11

    STX4 for paralogs           About GeneDecksing



    Genomic Variants
    for STX4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/120 NCBI SNPs in STX4 are shown (see all 120)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs80540461,2
    		C,F,--31043276(+) ACCCAT/CAAAGA 1 -- us2k15Minor allele frequency- C:0.46NA WA CSA 124
    rs1162530931,2
    		F,--31043419(+) AGGGTC/GCATTC 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1384628141,2
    		--31043449(+) CACAGA/TAGCTT 1 -- us2k10--------
    rs1429724601,2
    		--31043526(+) TGACCC/TTGGGG 1 -- us2k10--------
    rs1451014101,2
    		--31043698(+) CCCAGC/TACTTT 1 -- us2k10--------
    rs1928631801,2
    		--31043724(+) AAGGAC/TTGCTT 1 -- us2k10--------
    rs765289751,2
    		C,--31044052(+) CAGGGA/GGGCAG 1 -- us2k10--------
    rs1838060911,2
    		--31044053(+) AGGGAA/GGCAGC 1 -- us2k10--------
    rs1168465241,2
    		F,--31044139(+) CCGGGC/ATGCAG 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1388133341,2
    		C,--31044246(+) ACCCC-/CAGATTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for STX4 (31044210 - 31054296 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for STX4
         1 CNV: 4942

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for STX4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STX4 for disorders           About GeneDecksing

    OMIM gene information: 186591    OMIM disorders: --

    17 diseases for STX4:    About MalaCards
    renal carcinoma    carcinoma    inflammatory bowel disease    chronic myeloid leukemia
    myeloid leukemia    insulin resistance    renal cell carcinoma    tetanus
    hermaphroditism    leukemia    obesity    cholesterol
    retinitis    pancreatitis    malaria    neuronitis
    alcoholism

    2 diseases from the University of Copenhagen DISEASES database for STX4:
    Tetanus     Alcoholic pancreatitis
    Human Genome Epidemiology (HuGE) Navigator: STX4 (1 document)

    Export disorders for STX4 gene to outside databases

    Publications
    for STX4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STX4 gene, integrated from 9 sources (see all 148):
    (articles sorted by number of sources associating them with STX4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and sequence analysis of the human syntaxin-encoding gene. (PubMed id 8206394)1, 2, 3 Li H.... Seth A. (1994)
    2. Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. (PubMed id 8760387)1, 2, 9 Jagadish M.N....Ward C.W. (1996)
    3. Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. (PubMed id 16339081)1, 3, 9 Low S.H....Weimbs T. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
    7. Protease-activated receptor-1 activation of endotheli al cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. (PubMed id 15576373)1, 9 Fu J....Malik A.B. (2005)
    8. Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets. (PubMed id 10856305)1, 9 Chung S.H....Reed G.L. (2000)
    9. Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion. (PubMed id 10194441)1, 9 Reed G.L.... Fitzgerald M.L. (1999)
    10. Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4. (PubMed id 9045631)1, 9 Tellam J.T....James D.E. (1997)

    External Searches for STX4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing STX4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6810 HGNC: 11439 AceView: STX4A Ensembl:ENSG00000103496 euGenes: HUgn6810
    ECgene: STX4 Kegg: 6810 H-InvDB: STX4

    Other Databases showing STX4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STX4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STX4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for STX4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STX4 gene:
    Search GeneIP for patents involving STX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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