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STX4 Gene

protein-coding   GIFtS: 64
GCID: GC16P031044

Syntaxin 4

(Previous name: syntaxin 4A (placental))
(Previous symbol: STX4A)
  Search for STX4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Syntaxin 41 2
STX4A1 2 3 5
Syntaxin 4A (Placental)1 2
Renal Carcinoma Antigen NY-REN-312 3
p35-22
syntaxin-42

External Ids:    HGNC: 114391   Entrez Gene: 68102   Ensembl: ENSG000001034967   OMIM: 1865915   UniProtKB: Q128463   

Export aliases for STX4 gene to outside databases

Previous GC identifers: GC16P030953 GC16P028606


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STX4 Gene:
STX4 (syntaxin 4) is a protein-coding gene. GO annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is STX2.

UniProtKB/Swiss-Prot: STX4_HUMAN, Q12846
Function: Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of
SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in
docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity).
May also play a role in docking of synaptic vesicles at presynaptic active zones

Gene Wiki entry for STX4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STX4 gene promoter:
         E2F-4   E2F-3a   E2F-5   Tal-1   NCX/Ncx   E2F-2   E47   FOXI1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTX4 promoter sequence
   Search Chromatin IP Primers for STX4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

STX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STX4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031044:  view genomic region     (about GC identifiers)

Start:
31,044,210 bp from pter      End:
31,054,296 bp from pter
Size:
10,087 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STX4_HUMAN, Q12846 (See protein sequence)
Recommended Name: Syntaxin-4  
Size: 297 amino acids; 34180 Da
Subunit: Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during
lysosomal exocytosis. Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4.
Interacts with VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C-terminus) with
CENPF. Interacts with DOC2B. Interacts with STXBP6. Interacts with STXBP3; excludes interaction with DOC2B and
SNAP25. Interacts with STXBP4; excludes interaction with VAMP2 (By similarity)
Secondary accessions: Q15525 Q6FHE8

Explore the universe of human proteins at neXtProt for STX4: NX_Q12846

Explore proteomics data for STX4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys44, Lys91, Lys108, Lys243
  • Modification sites at PhosphoSitePlus

  • See STX4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001259024.1  NP_001259025.1  NP_004595.2  

    ENSEMBL proteins: 
     ENSP00000390788   ENSP00000378447   ENSP00000317714   ENSP00000454419   ENSP00000454841  
    Reactome Protein details: Q12846

    STX4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000727 T_SNARE_dom
     IPR010989 t-SNARE
     IPR006011 Syntaxin_N
     IPR006012 Syntaxin/epimorphin_CS

    Graphical View of Domain Structure for InterPro Entry Q12846

    ProtoNet protein and cluster: Q12846

    1 Blocks protein domain: IPB006011 Syntaxin

    UniProtKB/Swiss-Prot: STX4_HUMAN, Q12846
    Similarity: Belongs to the syntaxin family
    Similarity: Contains 1 t-SNARE coiled-coil homology domain


    Find genes that share domains with STX4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STX4_HUMAN, Q12846
    Function: Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of
    SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in
    docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity).
    May also play a role in docking of synaptic vesicles at presynaptic active zones

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding IEA--
    GO:0005484SNAP receptor activity IEA--
    GO:0005515protein binding IPI15576373
         
    Find genes that share ontologies with STX4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STX4:
     Increased circadian rhythm amp 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Stx4a):
     hematopoietic system  homeostasis/metabolism  mortality/aging 

    Find genes that share phenotypes with STX4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Stx4atm1Jepn for STX4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STX4
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    hsa-mir-16-5p (MIRT031473), hsa-mir-22-3p (MIRT050473)

    Block miRNA regulation of human, mouse, rat STX4 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate STX4:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-3907
    SwitchGear 3'UTR luciferase reporter plasmidSTX4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STX4

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    Addgene plasmids for STX4 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STX4_HUMAN, Q12846: Cell membrane; Single-pass type IV membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    vacuole4
    endosome2
    cytoskeleton1
    extracellular1
    golgi apparatus1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005773vacuole TAS16339081
    GO:0005802trans-Golgi network IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with STX4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STX4 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    2Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    Membrane Trafficking0.32
    trans-Golgi Network Vesicle Budding0.89
    Translocation of GLUT4 to the Plasma Membrane0.32
    3Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Disinhibition of SNARE formation0.00
    4Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    5Transmission across Chemical Synapses
    Neuronal System0.68


    Find genes that share SuperPaths with STX4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STX4
        Epithelial Tight Junctions

    3 BioSystems Pathways for STX4
        Insulin Signaling
    Insulin-mediated glucose transport
    Stabilization and expansion of the E-cadherin adherens junction


    3 Reactome Pathways for STX4
        Clathrin derived vesicle budding
    Disinhibition of SNARE formation
    Translocation of GLUT4 to the plasma membrane

    1 PharmGKB Pathway for STX4
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    2 Kegg Pathways  (Kegg details for STX4):
        SNARE interactions in vesicular transport
    Vasopressin-regulated water reabsorption

        Pathway & Disease-focused RT2 Profiler PCR Array including STX4: 
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for STX4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STX4 (Q128461, 2, 3 ENSP000003177144) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAPAP549201, 2, 3, ENSP000002633544EBI-744942,EBI-749652 MINT-68367 I2D: score=6 STRING: ENSP00000263354
    VAMP4O753792, 3, ENSP000002361924MINT-66593 I2D: score=5 STRING: ENSP00000236192
    VAMP3Q158363, ENSP000000546664I2D: score=4 STRING: ENSP00000054666
    STXBP3O001863, ENSP000003590254I2D: score=3 STRING: ENSP00000359025
    STXBP4Q6ZWJ13, ENSP000003655304I2D: score=2 STRING: ENSP00000365530
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006836neurotransmitter transport IEA--
    GO:0006886intracellular protein transport IEA--
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0007596blood coagulation TAS--
    GO:0016192vesicle-mediated transport ----

    Find genes that share ontologies with STX4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STX4

    8 Novoseek inferred chemical compound relationships for STX4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurotoxin c 84.7 2 17544372 (1), 10428873 (1)
    n-ethylmaleimide 44.5 1 11029050 (1)
    glucose 41.8 11 10394363 (2), 17001002 (1), 20053958 (1), 16516346 (1) (see all 9)
    cholesterol 0 1 16339081 (1)
    sucrose 0 1 12376543 (1)
    lipid 0 3 16513632 (2), 12376543 (1)
    calcium 0 5 14993220 (3), 9930733 (1), 9891020 (1)
    tyrosine 0 3 17916632 (2), 18541526 (1)

    1 PharmGKB related drug/compound annotation for STX4 gene    About this table
    Drug/compound PharmGKB Annotation
    warfarinCA  



    Find genes that share compounds with STX4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STX4 gene (3 alternative transcripts): 
    NM_001272095.1  NM_001272096.1  NM_004604.4  

    Unigene Cluster for STX4:

    Syntaxin 4
    Hs.83734  [show with all ESTs]
    Unigene Representative Sequence: NM_001272095
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457779 ENST00000493902 ENST00000394998(uc002eak.3) ENST00000313843(uc002eal.3 uc002eam.3)
    ENST00000487411 ENST00000460668 ENST00000496977 ENST00000566353 ENST00000461455
    ENST00000565483 ENST00000478150 ENST00000486660 ENST00000475862 ENST00000468583
    ENST00000503629(uc002ean.1) ENST00000564368
    miRNA
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    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-3907
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    Additional mRNA sequence: 

    AF026007.1 AF318489.1 AJ000541.1 AK091833.1 AK296652.1 AK315716.1 BC002436.2 BT007326.1 
    CR541806.1 U07158.1 X85784.1 

    16 DOTS entries:

    DT.455422  DT.95261426  DT.92438412  DT.97845234  DT.95261394  DT.40296648  DT.92438408  DT.100820929 
    DT.92438413  DT.91906619  DT.120728494  DT.120728498  DT.120728520  DT.95261364  DT.95261414  DT.427395 

    Selected AceView cDNA sequences (see all 211):

    BM560498 BU680910 BQ775670 CA941952 CF128389 BU626787 BQ775458 CB156159 
    CF272262 BF515538 BQ215940 BU620829 CA310926 BQ001578 BM544914 BM704147 
    AK091833 BU731968 CR590461 BQ935825 BG683117 BU903021 BI858588 BI222850 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STX4 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^
    SP1:                    -     -     -     -                                         -     -           -                             -                       -   
    SP2:                                                  -                             -     -           -                             -                       -   
    SP3:                                                  -                             -     -           -                             -                           
    SP4:                    -     -     -     -           -                             -     -                                                                     
    SP5:                                                                                -     -           -                                                         

    ExUns: 15
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for STX4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCCTCCT
    STX4 Expression
    About this image

    STX4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STX4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.83734

    UniProtKB/Swiss-Prot: STX4_HUMAN, Q12846
    Tissue specificity: Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils
    increases with differentiation

        Pathway & Disease-focused RT2 Profiler PCR Array including STX4: 
              Diabetes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for STX4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stx4a1 , 5 syntaxin 4A (placental)1, 5 87.91(n)1
    90.51(a)1
      7 (69.77 cM)5
    209091  NM_009294.31  NP_033320.11 
     1278242945 
    lizard
    (Anolis carolinensis)
    Reptilia STX46
    syntaxin 4
    65(a)
    1 ↔ 1
    GL343220.1(2046571-2078348)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.43722 Transcribed sequence with weak similarity to protein more 77.26(n)    CF220619.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc562722 similar to syntaxin 4A (placental) 71.92(n)   393190  AY394950.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syx46
    Syntaxin 4
    20(a)
    1 → many
    X(2633122-2638109)
    worm
    (Caenorhabditis elegans)
    Secernentea syx-26
    syx-36
    (see all 3)
    Protein SYX-3 (syx-3) mRNA, complete cds
    (see all 3)
    24(a)
    21(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(13960079-13962812) WBGene00006372
    X(5349098-5352393) WBGene00006371
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSO26
    SSO16
    Plasma membrane t-SNARE involved in fusion of secr...
    Plasma membrane t-SNARE involved in fusion of secr...
    23(a)
    22(a)
    many ↔ many
    many ↔ many
    XIII(626921-627808) YMR183C
    XVI(107275-108147) YPL232W


    ENSEMBL Gene Tree for STX4 (if available)
    TreeFam Gene Tree for STX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STX4 gene
    STX22  STX1A2  STX112  STX1B2  STX32  STX192  
    10 SIMAP similar genes for STX4 using alignment to 4 protein entries:     STX4_HUMAN (see all proteins):
    STX4A    DKFZp686L1857    STX2    stx1c    STX3    STX1B
    STX3A    STX1A    STX19    STX11

    Find genes that share paralogs with STX4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STX4 (see all 193)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs65652121,2
    C,F,H--31042425(+) GAGGGC/TACCCT 1 -- us2k119Minor allele frequency- T:0.04NS EA NA WA CSA 1460
    rs787135741,2
    C--31042440(+) AGTTTC/TCCAGC 1 -- us2k10--------
    rs107072651,2
    C--31042853(+) CTGGG-/TTTTTT 3 -- us2k1 trp32Minor allele frequency- T:0.00NA CSA 4
    rs1999672641,2
    C--31042865(+) TTTTTG/TTNNNN 3 -- us2k10--------
    rs80540461,2
    C,F--31043276(+) ACCCAT/CAAAGA 3 -- us2k15Minor allele frequency- C:0.46NA WA CSA 124
    rs1162530931,2
    F--31043419(+) AGGGTC/GCATTC 3 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1384628141,2
    C--31043449(+) CACAGA/TAGCTT 3 -- us2k10--------
    rs1429724601,2
    --31043526(+) TGACCC/TTGGGG 3 -- us2k10--------
    rs1451014101,2
    --31043698(+) CCCAGC/TACTTT 3 -- us2k10--------
    rs1928631801,2
    --31043724(+) AAGGAC/TTGCTT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for STX4 (31044210 - 31054296 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for STX4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv905729CNV Loss21882294
    dgv35n68CNV Loss17160897
    dgv2670n71CNV Loss21882294
    nsv457483CNV Loss19166990
    nsv833193CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STX4
    DNA2.0 Custom Variant and Variant Library Synthesis for STX4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 186591    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for STX4:
    Tetanus     Alcoholic pancreatitis

    Find genes that share disorders with STX4           About GenesLikeMe

    Genetic Association Database (GAD): STX4
    Human Genome Epidemiology (HuGE) Navigator: STX4 (1 document)

    Export disorders for STX4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STX4 gene, integrated from 10 sources (see all 155):
    (articles sorted by number of sources associating them with STX4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and sequence analysis of the human syntaxin-encoding gene. (PubMed id 8206394)1, 2, 3 Li H.... Seth A. (Gene 1994)
    2. Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. (PubMed id 8760387)1, 2, 9 Jagadish M.N....Ward C.W. (Biochem. J. 1996)
    3. Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. (PubMed id 16339081)1, 3, 9 Low S.H....Weimbs T. (Mol. Biol. Cell 2006)
    4. A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. (PubMed id 18535201)1, 4 Cooper G.M....Rieder M.J. (Blood 2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    8. Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. (PubMed id 15576373)1, 9 Fu J....Malik A.B. (J. Biol. Chem. 2005)
    9. Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets. (PubMed id 10856305)1, 9 Chung S.H....Reed G.L. (J. Biol. Chem. 2000)
    10. Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion. (PubMed id 10194441)1, 9 Reed G.L.... Fitzgerald M.L. (Blood 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6810 HGNC: 11439 AceView: STX4A Ensembl:ENSG00000103496 euGenes: HUgn6810
    ECgene: STX4 Kegg: 6810 H-InvDB: STX4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STX4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for STX4 gene:
    Search GeneIP for patents involving STX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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