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Aliases for STX4 Gene

Aliases for STX4 Gene

  • Syntaxin 4 2 3 5
  • Renal Carcinoma Antigen NY-REN-31 3 4
  • Syntaxin 4A (Placental) 2 3
  • STX4A 3 4
  • Syntaxin-4 3
  • P35-2 3

External Ids for STX4 Gene

Previous HGNC Symbols for STX4 Gene

  • STX4A

Previous GeneCards Identifiers for STX4 Gene

  • GC16P030953
  • GC16P031044
  • GC16P028606

Summaries for STX4 Gene

GeneCards Summary for STX4 Gene

STX4 (Syntaxin 4) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include SNARE binding and sphingomyelin phosphodiesterase activator activity. An important paralog of this gene is STX1B.

UniProtKB/Swiss-Prot for STX4 Gene

  • Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.

Gene Wiki entry for STX4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX4 Gene

Genomics for STX4 Gene

Regulatory Elements for STX4 Gene

Enhancers for STX4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G031351 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.3 +321.9 321919 7.2 HDGF PKNOX1 ATF1 WRNIP1 ZNF143 FOS SP3 JUNB TBX21 SMARCA4 ITGAX STX4 PYDC1 KAT8 ITGAM ZNF646 ARMC5 ZNF764 HSD3B7 LOC647086
GH16G031116 1.8 FANTOM5 ENCODE dbSUPER 19.2 +85.5 85524 3.9 HDGF PKNOX1 ARNT AGO1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 KAT8 ENSG00000261614 ITGAX STX4 ENSG00000260304 BCL7C ENSG00000260625 ENSG00000260267 ZNF646 ITGAM
GH16G031111 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.3 +80.4 80437 3.5 DRAP1 SAP130 AGO1 ARID4B MAX GLI4 RAD21 ZNF121 POLR2A PRDM10 KAT8 ITGAX STX4 ZNF646 ITGAM HSD3B7 FUS ZNF668 PYCARD BCKDK
GH16G031349 1.5 FANTOM5 Ensembl ENCODE dbSUPER 16.9 +317.5 317527 1.2 BCOR ZNF146 ZMYM3 MAX EGR2 ITGAX STX4 PYDC1 KAT8 ITGAM ZNF646 ARMC5 HSD3B7 ZNF668 FUS
GH16G031125 2 FANTOM5 Ensembl ENCODE dbSUPER 8.7 +98.3 98250 10.7 CREB3L1 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 KAT8 ITGAX ZNF764 BCL7C ITGAM ZNF646 ZNF668 ENSG00000260267 ENSG00000260304 NPIPB13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STX4 on UCSC Golden Path with GeneCards custom track

Promoters for STX4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085289 405 1801 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for STX4 Gene

Chromosome:
16
Start:
31,032,889 bp from pter
End:
31,042,975 bp from pter
Size:
10,087 bases
Orientation:
Plus strand

Genomic View for STX4 Gene

Genes around STX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX4 Gene

Proteins for STX4 Gene

  • Protein details for STX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12846-STX4_HUMAN
    Recommended name:
    Syntaxin-4
    Protein Accession:
    Q12846
    Secondary Accessions:
    • A8MXY0
    • Q15525
    • Q6FHE8

    Protein attributes for STX4 Gene

    Size:
    297 amino acids
    Molecular mass:
    34180 Da
    Quaternary structure:
    • Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis. Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C-terminus) with CENPF. Interacts with DOC2B. Interacts with STXBP6. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with STXBP4; excludes interaction with VAMP2 (By similarity).

    Alternative splice isoforms for STX4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX4 Gene

Post-translational modifications for STX4 Gene

  • Ubiquitination at Lys44, posLast=9191, and isoforms=2243
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STX4 Gene

Domains & Families for STX4 Gene

Gene Families for STX4 Gene

Protein Domains for STX4 Gene

Graphical View of Domain Structure for InterPro Entry

Q12846

UniProtKB/Swiss-Prot:

STX4_HUMAN :
  • Belongs to the syntaxin family.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX4: view

Function for STX4 Gene

Molecular function for STX4 Gene

UniProtKB/Swiss-Prot Function:
Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.

Gene Ontology (GO) - Molecular Function for STX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 12130530
GO:0016230 sphingomyelin phosphodiesterase activator activity IMP 20956541
genes like me logo Genes that share ontologies with STX4: view
genes like me logo Genes that share phenotypes with STX4: view

Animal Models for STX4 Gene

MGI Knock Outs for STX4:

Animal Model Products

  • Taconic Biosciences Mouse Models for STX4

miRNA for STX4 Gene

miRTarBase miRNAs that target STX4

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for STX4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STX4 Gene

Localization for STX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX4 Gene

Cell membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STX4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
endosome 5
golgi apparatus 3
lysosome 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000322 storage vacuole IEA --
GO:0005615 extracellular space IDA 22226963
GO:0005622 intracellular IDA 24055037
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IDA 20956541
genes like me logo Genes that share ontologies with STX4: view

Pathways & Interactions for STX4 Gene

genes like me logo Genes that share pathways with STX4: view

Gene Ontology (GO) - Biological Process for STX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006836 neurotransmitter transport IEA --
GO:0006886 intracellular protein transport IBA --
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0008284 positive regulation of cell proliferation IMP 21720706
genes like me logo Genes that share ontologies with STX4: view

No data available for SIGNOR curated interactions for STX4 Gene

Drugs & Compounds for STX4 Gene

(8) Drugs for STX4 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenprocoumon Approved Pharma 32
Warfarin Approved Pharma 470

(2) Additional Compounds for STX4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STX4: view

Transcripts for STX4 Gene

Unigene Clusters for STX4 Gene

Syntaxin 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for STX4

Alternative Splicing Database (ASD) splice patterns (SP) for STX4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - -
SP8: -
SP9:
SP10: -
SP11: -
SP12:
SP13: -

ExUns: 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for STX4 Gene

GeneLoc Exon Structure for
STX4
ECgene alternative splicing isoforms for
STX4

Expression for STX4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STX4 Gene

Protein differential expression in normal tissues from HIPED for STX4 Gene

This gene is overexpressed in Nasal epithelium (19.8) and Lavage (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STX4 Gene



Protein tissue co-expression partners for STX4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STX4 Gene:

STX4

SOURCE GeneReport for Unigene cluster for STX4 Gene:

Hs.83734

mRNA Expression by UniProt/SwissProt for STX4 Gene:

Q12846-STX4_HUMAN
Tissue specificity: Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation.

Evidence on tissue expression from TISSUES for STX4 Gene

  • Muscle(4.5)
  • Blood(4.4)
  • Lung(4.4)
  • Eye(4.3)
  • Skin(4.3)
  • Liver(4.2)
  • Nervous system(2.5)
  • Pancreas(2.2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with STX4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STX4 Gene

Orthologs for STX4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STX4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STX4 34
  • 92.3 (n)
cow
(Bos Taurus)
Mammalia STX4 34 35
  • 92.23 (n)
dog
(Canis familiaris)
Mammalia STX4 34 35
  • 91.67 (n)
mouse
(Mus musculus)
Mammalia Stx4a 34 16 35
  • 87.91 (n)
rat
(Rattus norvegicus)
Mammalia Stx4 34
  • 86.21 (n)
oppossum
(Monodelphis domestica)
Mammalia STX4 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX4 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX4 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4372 34
zebrafish
(Danio rerio)
Actinopterygii stx4 34 35
  • 58.56 (n)
zgc56272 34
fruit fly
(Drosophila melanogaster)
Insecta Syx4 35
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea syx-2 35
  • 24 (a)
ManyToMany
syx-3 35
  • 21 (a)
ManyToMany
syx-4 35
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSO2 35
  • 23 (a)
ManyToMany
SSO1 35
  • 22 (a)
ManyToMany
Species where no ortholog for STX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX4 Gene

ENSEMBL:
Gene Tree for STX4 (if available)
TreeFam:
Gene Tree for STX4 (if available)

Paralogs for STX4 Gene

Paralogs for STX4 Gene

(10) SIMAP similar genes for STX4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with STX4: view

Variants for STX4 Gene

Sequence variations from dbSNP and Humsavar for STX4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000369536 -- 31,037,643(+) CAACA(A/G)GAGTG intron-variant
rs1000586302 -- 31,033,152(+) CGCGG(A/G)GGCCG upstream-variant-2KB, utr-variant-5-prime
rs1000623305 -- 31,032,848(+) CTGGC(A/C)GCCCA upstream-variant-2KB
rs1000760768 -- 31,032,718(+) GGGGT(A/G)TGAGT upstream-variant-2KB
rs1000816221 -- 31,032,408(+) TTGCT(C/T)AAGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for STX4 Gene

Variant ID Type Subtype PubMed ID
dgv35n68 CNV loss 17160897
nsv457483 CNV loss 19166990
nsv571820 CNV loss 21841781
nsv833193 CNV gain+loss 17160897

Variation tolerance for STX4 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX4 Gene

Disorders for STX4 Gene

Relevant External Links for STX4

Genetic Association Database (GAD)
STX4
Human Genome Epidemiology (HuGE) Navigator
STX4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STX4

No disorders were found for STX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX4 Gene

Publications for STX4 Gene

  1. Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. (PMID: 16339081) Low S.H. … Weimbs T. (Mol. Biol. Cell 2006) 2 3 22 64
  2. Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. (PMID: 8760387) Jagadish M.N. … Ward C.W. (Biochem. J. 1996) 3 4 22 64
  3. Isolation and sequence analysis of the human syntaxin-encoding gene. (PMID: 8206394) Li H. … Seth A. (Gene 1994) 2 3 4 64
  4. Syntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines. (PMID: 20434989) Kennedy M.J. … Ehlers M.D. (Cell 2010) 3 22 64
  5. Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils. (PMID: 18588921) Brochetta C. … Blank U. (Biochim. Biophys. Acta 2008) 3 22 64

Products for STX4 Gene

  • Addgene plasmids for STX4

Sources for STX4 Gene

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