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STX3 Gene

protein-coding   GIFtS: 62
GCID: GC11P059480

Syntaxin 3

(Previous name: syntaxin 3A)
(Previous symbol: STX3A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Syntaxin 31 2
STX3A1 2 3 5
Syntaxin 3A1 2
syntaxin-32

External Ids:    HGNC: 114381   Entrez Gene: 68092   Ensembl: ENSG000001669007   OMIM: 6008765   UniProtKB: Q132773   

Export aliases for STX3 gene to outside databases

Previous GC identifers: GC11P059280 GC11P059522 GC11P055873


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STX3 Gene:
The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial
cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein
trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, May 2010)

GeneCards Summary for STX3 Gene:
STX3 (syntaxin 3) is a protein-coding gene. Diseases associated with STX3 include tetanus, and diarrhea. GO annotations related to this gene include SNAP receptor activity and arachidonic acid binding. An important paralog of this gene is STX2.

UniProtKB/Swiss-Prot: STX3_HUMAN, Q13277
Function: Potentially involved in docking of synaptic vesicles at presynaptic active zones

Gene Wiki entry for STX3 (Syntaxin 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STX3 gene promoter:
         Nkx3-1   Nkx3-1 v4   Bach2   Nkx3-1 v1   Nkx3-1 v2   POU2F1   POU2F1b   POU2F1a   Nkx3-1 v3   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTX3 promoter sequence
   Search Chromatin IP Primers for STX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

STX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STX3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P059480:  view genomic region     (about GC identifiers)

Start:
59,480,929 bp from pter      End:
59,573,355 bp from pter
Size:
92,427 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STX3_HUMAN, Q13277 (See protein sequence)
Recommended Name: Syntaxin-3  
Size: 289 amino acids; 33155 Da
Secondary accessions: B4DME0 O43750 O43751 Q15360
Alternative splicing: 3 isoforms:  Q13277-1   Q13277-2   Q13277-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STX3: NX_Q13277

Explore proteomics data for STX3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171511.1  NP_004168.1  

    ENSEMBL proteins: 
     ENSP00000338562   ENSP00000436200   ENSP00000433248   ENSP00000431386   ENSP00000434836  
     ENSP00000441649   ENSP00000300150   ENSP00000393536  

    STX3 Human Recombinant Protein Products:

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    Novus Biologicals STX3 Proteins
    Novus Biologicals STX3 Lysate
    Sino Biological Recombinant Protein for STX3
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for STX3
    Cloud-Clone Corp. Proteins for STX3

    STX3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of STX3
    Browse R&D Systems for Antibodies
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    Abcam antibodies for STX3 (Q16623, Q13277, P61266, P32856)
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    ThermoFisher Antibodies for STX3
    LSBio Antibodies in human, mouse, rat for STX3

    STX3 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STX3
    Cloud-Clone Corp. CLIAs for STX3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000727 T_SNARE_dom
     IPR010989 t-SNARE
     IPR006011 Syntaxin_N
     IPR006012 Syntaxin/epimorphin_CS

    Graphical View of Domain Structure for InterPro Entry Q13277

    ProtoNet protein and cluster: Q13277

    1 Blocks protein domain: IPB006011 Syntaxin

    UniProtKB/Swiss-Prot: STX3_HUMAN, Q13277
    Similarity: Belongs to the syntaxin family
    Similarity: Contains 1 t-SNARE coiled-coil homology domain


    STX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STX3_HUMAN, Q13277
    Function: Potentially involved in docking of synaptic vesicles at presynaptic active zones

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005484SNAP receptor activity IEA--
    GO:0005515protein binding IPI17693260
    GO:0050544arachidonic acid binding ISS--
         
    STX3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for STX3:
     Increased cell number in G1, a 

         1 MGI phenotypic allele for Stx3 (no phenotypes)

    STX3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Stx3tm1(KOMP)Vlcg for STX3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STX3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STX3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STX3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STX3

    miRNA
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    miRTarBase miRNAs that target STX3:
    hsa-mir-92a-3p (MIRT049197), hsa-mir-375 (MIRT019943)

    Block miRNA regulation of human, mouse, rat STX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STX3 (see all 57):
    hsa-miR-579 hsa-miR-3685 hsa-miR-607 hsa-let-7d hsa-miR-146a hsa-let-7g hsa-miR-149 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidSTX3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STX3
    Predesigned siRNA for gene silencing in human, mouse, rat STX3

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for STX3 (see all 10)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): STX3 (NM_004177)
    Sino Biological Human cDNA Clone for STX3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for STX3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STX3_HUMAN, Q13277: Membrane; Single-pass type IV membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    vacuole5
    plasma membrane4
    cytosol3
    cytoskeleton1
    endoplasmic reticulum1
    endosome1
    golgi apparatus1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005773vacuole TAS16339081
    GO:0005911cell-cell junction IDA15576373
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0016324apical plasma membrane IDA16339081

    STX3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STX3 About    
    See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    Synaptic vesicle cycle0.50
    2Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    3Transmission across Chemical Synapses
    Neuronal System0.68
    4Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STX3
        Epithelial Tight Junctions

    1 BioSystems Pathway for STX3
        Synaptic Vesicle Pathway


    1 PharmGKB Pathway for STX3
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    2 Kegg Pathways  (Kegg details for STX3):
        SNARE interactions in vesicular transport
    Synaptic vesicle cycle


    STX3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STX3
    Interactions:

        GeneGlobe Interaction Network for STX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STX3 (Q132771, 2, 3 ENSP000003385624) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZFYVE9O954051, 3, ENSP000002877274EBI-1394295,EBI-296817 I2D: score=1 STRING: ENSP00000287727
    STXBP1P617643, ENSP000003623994I2D: score=5 STRING: ENSP00000362399
    VAMP3Q158363, ENSP000000546664I2D: score=3 STRING: ENSP00000054666
    SNAP29O957213, ENSP000002157304I2D: score=2 STRING: ENSP00000215730
    SYT1P215793, ENSP000002612054I2D: score=2 STRING: ENSP00000261205
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006836neurotransmitter transport IEA--
    GO:0006886intracellular protein transport IEA--
    GO:0006887exocytosis IEA--
    GO:0016192vesicle-mediated transport ----
    GO:0031175neuron projection development ISS--

    STX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STX3

    5 Novoseek inferred chemical compound relationships for STX3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurotoxin c 88.1 1 17544372 (1)
    n-ethylmaleimide 52 5 9701566 (1), 15943887 (1), 18245078 (1), 9614185 (1)
    cholesterol 0 2 15469992 (1), 16339081 (1)
    sodium 0 1 10990372 (1)
    calcium 0 2 12949219 (1), 9930733 (1)



    STX3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STX3 gene (2 alternative transcripts): 
    NM_001178040.1  NM_004177.4  

    Unigene Cluster for STX3:

    Syntaxin 3
    Hs.180711  [show with all ESTs]
    Unigene Representative Sequence: NM_004177
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337979 ENST00000533637 ENST00000529177 ENST00000530498 ENST00000528805
    ENST00000530221 ENST00000535361(uc009ymt.1 uc001nog.3 uc010rkx.2 uc010rky.2)
    ENST00000300150 ENST00000437946
    miRNA
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    Block miRNA regulation of human, mouse, rat STX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STX3 (see all 57):
    hsa-miR-579 hsa-miR-3685 hsa-miR-607 hsa-let-7d hsa-miR-146a hsa-let-7g hsa-miR-149 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidSTX3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): STX3 (NM_004177)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX3
    Primer
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    OriGene qPCR primer pairs and template standards for STX3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STX3
      QuantiTect SYBR Green Assays in human, mouse, rat STX3
      QuantiFast Probe-based Assays in human, mouse, rat STX3

    Additional mRNA sequence: 

    AJ002076.1 AJ002077.1 AK055468.1 AK125660.1 AK290251.1 AK293494.1 AK297419.1 AK312909.1 
    BC007405.2 BC007429.2 BT006666.1 BX538158.1 U32315.1 X90581.1 

    18 DOTS entries:

    DT.452030  DT.120739578  DT.211785  DT.436025  DT.100822954  DT.95069087  DT.100822963  DT.120739592 
    DT.86858786  DT.91753474  DT.100822962  DT.75172258  DT.75170049  DT.92057350  DT.92455071  DT.100684068 
    DT.103423  DT.91805408 

    Selected AceView cDNA sequences (see all 280):

    AI690545 BF939642 BU621412 BU527496 AI335885 BC007405 AJ002077 BG750746 
    AA973225 BU674870 AU130544 AI521140 BM771584 BQ691433 BI335859 NM_004177 
    AA854911 AI272129 BG696455 AI023957 CA448754 AA973757 BE747117 AI660630 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for STX3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                                -     -                                                         
    SP2:                                -     -                             -                           
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                          -     -               


    ECgene alternative splicing isoforms for STX3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGGTTTT
    STX3 Expression
    About this image


    STX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)
             Heart Tube
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    STX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STX3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.180711
        Custom PCR Arrays for STX3
    Primer
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    OriGene qPCR primer pairs and template standards for STX3
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    QuantiFast Probe-based Assays in human, mouse, rat STX3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STX3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stx31 , 5 syntaxin 31, 5 91.78(n)1
    98.26(a)1
      19 (8.52 cM)5
    209081  NM_152220.21  NP_689344.11 
     117751195 
    chicken
    (Gallus gallus)
    Aves STX31 syntaxin 3 76.59(n)
    83.97(a)
      428839  XM_003641274.2  XP_003641322.2 
    lizard
    (Anolis carolinensis)
    Reptilia STX36
    syntaxin 3
    88(a)
    1 ↔ 1
    1(90900035-90942806)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.149962 Transcribed sequence with moderate similarity to protein more 76.17(n)    BX728803.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc659542 Syntaxin 3 74.08(n)   393515  BC056333.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syx1A6
    Syntaxin 1A
    54(a)
    1 → many
    3R(19927322-19931465)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-646
    Protein UNC-64, isoform a (unc-64) mRNA, complete ...
    53(a)
    1 → many
    III(13277261-13284364) WBGene00006798


    ENSEMBL Gene Tree for STX3 (if available)
    TreeFam Gene Tree for STX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STX3 gene
    STX22  STX1A2  STX112  STX1B2  STX192  STX42  
    11 SIMAP similar genes for STX3 using alignment to 5 protein entries:     STX3_HUMAN (see all proteins):
    STX3A    DKFZp686L1857    STX2    stx1c    STX1A    STX1B
    STX4A    STX4    STX11    STX19    STX16

    STX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STX3 (see all 1128)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5638001,2
    C,F--59520568(+) gtggtG/Atgatc 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs4792641,2
    C,F--59520593(-) ggaagC/Aagagg 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1849697681,2
    C--59520688(+) ATTTTC/TAGTAG 2 -- us2k10--------
    rs1880923541,2
    --59520697(+) AGAGAC/TGAGGT 2 -- us2k10--------
    rs1440423591,2
    C--59520735(+) AACTCC/TTAACT 2 -- us2k10--------
    rs1930754861,2
    --59520807(+) CCCGGC/TCAGTT 2 -- us2k10--------
    rs1400621871,2
    --59520827(+) TTAACA/GTGTTC 2 -- us2k10--------
    rs1853261741,2
    --59520832(+) ATGTTC/TGTTTC 2 -- us2k10--------
    rs1420596541,2
    --59520938(+) TCTTTG/TATGTG 2 -- us2k10--------
    rs1463439311,2
    --59520947(+) TGTGTG/TCATTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for STX3 (59480929 - 59573355 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for STX3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STX3
    DNA2.0 Custom Variant and Variant Library Synthesis for STX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600876    OMIM disorders: --

    8 diseases for STX3:    
    About MalaCards
    tetanus    diarrhea    cystic fibrosis    retinoblastoma
    pancreatitis    neuronitis    prostatitis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for STX3:
    Tetanus

    STX3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for STX3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tetanus 20 1 9614185 (1)
    cystic fibrosis 4.59 1 10990372 (1)

    Genetic Association Database (GAD): STX3
    Human Genome Epidemiology (HuGE) Navigator: STX3 (1 document)

    Export disorders for STX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STX3 gene, integrated from 10 sources (see all 94):
    (articles sorted by number of sources associating them with STX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. (PubMed id 16339081)1, 3, 9 Low S.H....Weimbs T. (Mol. Biol. Cell 2006)
    2. Human syntaxin 3 is localized apically in human intestinal cells. (PubMed id 9378770)1, 2, 9 Delgrossi M.H.... le Bivic A. (J. Cell Sci. 1997)
    3. Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. (PubMed id 10080545)1, 2, 9 Martin-Martin B.... Mollinedo F. (J. Leukoc. Biol. 1999)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells. (PubMed id 10788461)1, 9 Riento K....Olkkonen V.M. (J. Biol. Chem. 2000)
    8. Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells. (PubMed id 9701566)1, 9 Riento K....Olkkonen V.M. (J. Cell. Sci. 1998)
    9. Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3. (PubMed id 16598260)3, 9 Darios F. and Davletov B. (Nature 2006)
    10. A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. (PubMed id 9614185)1, 9 Galli T....Louvard D. (Mol. Biol. Cell 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 6809 HGNC: 11438 AceView: STX3AandOR10Y1P Ensembl:ENSG00000166900 euGenes: HUgn6809
    ECgene: STX3 Kegg: 6809 H-InvDB: STX3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STX3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for STX3 gene:
    Search GeneIP for patents involving STX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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