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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STX3 Gene

protein-coding   GIFtS: 61
GCID: GC11P059480

syntaxin 3

(Previous name: syntaxin 3A )
(Previous symbol: STX3A)
 Explore 10 diseases affiliated with
STX3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STX3    

Aliases
for STX3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Syntaxin 31 2
STX3A1 2 3 5
Syntaxin 3A1 2
Syntaxin-31

External Ids:    HGNC: 114381   Entrez Gene: 68092   Ensembl: ENSG000001669007   OMIM: 6008765   UniProtKB: Q132773   

Export aliases for STX3 gene to outside databases

Previous GC identifers: GC11P059280 GC11P059522 GC11P055873


Summaries
for STX3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for STX3:
The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells
where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking
involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, May 2010)

UniProtKB/Swiss-Prot: STX3_HUMAN, Q13277
Function: Potentially involved in docking of synaptic vesicles at presynaptic active zones

Gene Wiki entry for STX3 (Syntaxin 3)


Genomic Views
for STX3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STX3 gene promoter:
         Nkx3-1   Nkx3-1 v4   Bach2   Nkx3-1 v1   Nkx3-1 v2   POU2F1   POU2F1b   POU2F1a   Nkx3-1 v3   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STX3 promoter sequence
   Search SABiosciences Chromatin IP Primers for STX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

STX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STX3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P059480:  view genomic region     (about GC identifiers)

Start:
 59,480,929 bp from pter      End:
 59,573,355 bp from pter
Size:
 92,427 bases      Orientation:
 plus strand

Proteins
for STX3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STX3_HUMAN, Q13277 (See protein sequence)
Recommended Name: Syntaxin-3  
Size: 289 amino acids; 33155 Da
Subcellular location: Membrane; Single-pass type IV membrane protein (Potential)
Secondary accessions: B4DME0 O43750 O43751 Q15360
Alternative splicing: 3 isoforms:  Q13277-1   Q13277-2   Q13277-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STX3: NX_Q13277

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13277

    • STX3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171511.1  NP_004168.1  

    ENSEMBL proteins: 
     ENSP00000338562   ENSP00000436200   ENSP00000433248   ENSP00000431386   ENSP00000434836  
     ENSP00000441649   ENSP00000300150   ENSP00000393536  
    Reactome Protein details: Q13277
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: STX3
    OriGene Protein Over-expression Lysate (see all 2): STX3
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    Novus Biologicals STX3 Proteins
    Novus Biologicals STX3 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for STX3
    Uscn Proteins for STX3

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005773vacuole TAS16339081
    GO:0005911cell-cell junction IDA15576373
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--


    STX3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for STX3

    Protein Domains /
    Families
    for STX3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STX3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000727 T_SNARE_dom
     IPR010989 t-SNARE
     IPR006011 Syntaxin_N
     IPR015708 Syntaxin-3
     IPR006012 Syntaxin/epimorphin_CS

    Graphical View of Domain Structure for InterPro Entry Q13277

    ProtoNet protein and cluster: Q13277

    1 Blocks protein family: IPB006011 Syntaxin

    UniProtKB/Swiss-Prot: STX3_HUMAN, Q13277
    Similarity: Belongs to the syntaxin family
    Similarity: Contains 1 t-SNARE coiled-coil homology domain


    Function
    for STX3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STX3_HUMAN, Q13277
    Function: Potentially involved in docking of synaptic vesicles at presynaptic active zones

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STX3
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate STX3 (see all 57):
    hsa-miR-579 hsa-miR-3685 hsa-miR-607 hsa-let-7d hsa-miR-146a hsa-let-7g hsa-miR-149 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmid: STX3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STX3 (see all 7)
    OriGene shRNA RFP: STX3
    OriGene siRNA: STX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): STX3 (NM_004177)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX3 

    Cell Line
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    Search LifeMap BioReagents cell lines for STX3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005484SNAP receptor activity IEA--
    GO:0005515protein binding IPI17693260
    GO:0050544arachidonic acid binding ISS--


    STX3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for STX3:
     Increased cell number in G1, a 


    Pathways & Interactions
    for STX3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Botulinum neurotoxicity
    		Botulinum neurotoxicity1.00
    		Proteolytic cleavage of SNARE complex proteins0.89
    2Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    		Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics1.00
    		SNARE interactions in vesicular transport0.40
    3Synaptic Vesicle Pathway
    		Synaptic Vesicle Pathway1.00
    4Disease
    		Disease1.00
    5Transmission across Chemical Synapses
    		Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for STX3 
        Synaptic Vesicle Pathway

    4        Reactome Pathways for STX3
        Proteolytic cleavage of SNARE complex proteins
    Botulinum neurotoxicity
    Neuronal System
    Disease

    1 PharmGKB Pathway for STX3
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    1         Kegg Pathway  (Kegg details for STX3):
        SNARE interactions in vesicular transport


    STX3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for STX3 (Q132771, 2, 3 ENSP000003385624) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZFYVE9O954051, 3, ENSP000002877274EBI-1394295,EBI-296817 I2D: score=1 STRING: ENSP00000287727
    STXBP1P617643, ENSP000003623994I2D: score=5 STRING: ENSP00000362399
    VAMP3Q158363, ENSP000000546664I2D: score=3 STRING: ENSP00000054666
    SNAP29O957213, ENSP000002157304I2D: score=2 STRING: ENSP00000215730
    SYT1P215793, ENSP000002612054I2D: score=2 STRING: ENSP00000261205
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006836neurotransmitter transport IEA--
    GO:0006886intracellular protein transport IEA--
    GO:0006887exocytosis IEA--
    GO:0006944cellular membrane fusion IEA--
    GO:0016192vesicle-mediated transport ----


    STX3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for STX3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STX3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STX3
    5 Novoseek chemical compound relationships for STX3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurotoxin c 88.1 1 17544372 (1)
    n-ethylmaleimide 52 5 9701566 (1), 15943887 (1), 18245078 (1), 9614185 (1)
    cholesterol 0 2 15469992 (1), 16339081 (1)
    sodium 0 1 10990372 (1)
    calcium 0 2 12949219 (1), 9930733 (1)

    Search CenterWatch for drugs/clinical trials and news about STX3 

    Transcripts
    for STX3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STX3 gene (2 alternative transcripts): 
    NM_001178040.1  NM_004177.4  

    Unigene Cluster for STX3:

    Syntaxin 3
    Hs.180711  [show with all ESTs]
    Unigene Representative Sequence: NM_004177
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337979 ENST00000533637 ENST00000529177 ENST00000530498 ENST00000528805
    ENST00000530221 ENST00000535361(uc009ymt.1 uc001nog.3 uc010rkx.2 uc010rky.2)
    ENST00000300150 ENST00000437946

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STX3
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate STX3 (see all 57):
    hsa-miR-579 hsa-miR-3685 hsa-miR-607 hsa-let-7d hsa-miR-146a hsa-let-7g hsa-miR-149 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmid: STX3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STX3 (see all 7)
    OriGene shRNA RFP: STX3
    OriGene siRNA: STX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX3
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): STX3 (NM_004177)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX3 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX3

    Additional cDNA sequence: 

    AJ002076.1 AJ002077.1 AK055468.1 AK125660.1 AK290251.1 AK293494.1 AK297419.1 AK312909.1 
    BC007405.2 BC007429.2 BT006666.1 BX538158.1 U32315.1 X90581.1 

    18 DOTS entries:

    DT.452030  DT.120739578  DT.211785  DT.436025  DT.100822954  DT.95069087  DT.100822963  DT.120739592 
    DT.86858786  DT.91753474  DT.100822962  DT.75172258  DT.75170049  DT.92057350  DT.92455071  DT.100684068 
    DT.103423  DT.91805408 

    24/280 AceView cDNA sequences (see all 280):

    BM765832 AU135955 AA503739 BM461747 BF431905 AA024800 BU167931 AA483820 
    BM748168 BM968477 BQ920900 CB214978 BC007429 BF109887 AJ002077 BC007405 
    BG750746 AA973225 BU674870 AI521140 AU130544 BM742327 BG744114 BQ073246 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for STX3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                                -     -                                                         
    SP2:                                -     -                             -                           
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                          -     -               


    ECgene alternative splicing isoforms for STX3

    Expression
    for STX3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAAGGTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    STX3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium

    See STX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STX3

    SOURCE GeneReport for Unigene cluster: Hs.180711
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    In Situ
    Assay Products:     
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    Orthologs
    for STX3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STX3 gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves STX31 syntaxin 3 74.59(n)
    80.85(a)    		   428839  XM_003641274.1  XP_003641322.1 
    lizard
    (Anolis carolinensis)    		 Reptilia STX36
    		 --
    		 85(a)
    		 1 ↔ 1
    		 1(90900044-90912853)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.149962 Transcribed sequence with moderate similarity to protein more 76.17(n)    BX728803.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc659542 Syntaxin 3 74.08(n)   393515  BC056333.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Syx1A6
    		 Syntaxin 1A
    		 54(a)
    		 1 → many
    		 3R(19927322-19931465)
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-646
    		 Syntaxin-1A homolog
    		 55(a)
    		 1 → many
    		 III(13277160-13284263)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SYP1236
    SYP1256
    (see all 9)    		 syntaxin-125
    (see all 9)    		 21(a)
    20(a)
    (see all 9)    		 many ↔ many
    many ↔ many
    (see all 9)    		 4(1466336-1467750)
    1(3768724-3769706)
    rice
    (Oryza sativa)    		 Liliopsida Os07g05289001 hypothetical protein 44.71(n)
    28.11(a)    		   4343440  NM_001066373.2  NP_001059838.2 


    ENSEMBL Gene Tree for STX3 (if available)
    TreeFam Gene Tree for STX3 (if available) 

    Paralogs
    for STX3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STX3 gene
    STX22  STX1A2  STX112  STX1B2  STX192  STX42  
    11 SIMAP similar genes for STX3 using alignment to 5 protein entries:     STX3_HUMAN (see all proteins):
    STX3A    DKFZp686L1857    STX2    stx1c    STX1A    STX1B
    STX4A    STX4    STX11    STX19    STX16

    STX3 for paralogs           About GeneDecksing



    Genomic Variants
    for STX3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/915 NCBI SNPs in STX3 are shown (see all 915)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs5638001,2
    		--59520568(+) gtggtG/Atgatc 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs4792641,2
    		--59520593(-) ggaagC/Aagagg 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1849697681,2
    		--59520688(+) ATTTTC/TAGTAG 2 -- us2k10--------
    rs1880923541,2
    		--59520697(+) AGAGAC/TGAGGT 2 -- us2k10--------
    rs1440423591,2
    		--59520735(+) AACTCC/TTAACT 2 -- us2k10--------
    rs1930754861,2
    		--59520807(+) CCCGGC/TCAGTT 2 -- us2k10--------
    rs1400621871,2
    		--59520827(+) TTAACA/GTGTTC 2 -- us2k10--------
    rs1853261741,2
    		--59520832(+) ATGTTC/TGTTTC 2 -- us2k10--------
    rs1420596541,2
    		--59520938(+) TCTTTG/TATGTG 2 -- us2k10--------
    rs1463439311,2
    		--59520947(+) TGTGTG/TCATTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for STX3 (59480929 - 59573355 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for STX3: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for STX3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STX3 for disorders           About GeneDecksing

    OMIM gene information: 600876    OMIM disorders: --

    10 diseases for STX3:    About MalaCards
    cystic fibrosis    tetanus    fibrosis    diarrhea
    hermaphroditism    retinoblastoma    cholesterol    pancreatitis
    malaria    neuronitis

    1 disease from the University of Copenhagen DISEASES database for STX3:
    Tetanus

    2 Novoseek disease relationships for STX3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tetanus 20 1 9614185 (1)
    cystic fibrosis 4.59 1 10990372 (1)

    Human Genome Epidemiology (HuGE) Navigator: STX3 (1 document)

    Export disorders for STX3 gene to outside databases

    Publications
    for STX3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STX3 gene, integrated from 9 sources (see all 91):
    (articles sorted by number of sources associating them with STX3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. (PubMed id 16339081)1, 3, 9 Low S.H....Weimbs T. (2006)
    2. Human syntaxin 3 is localized apically in human intestinal cells. (PubMed id 9378770)1, 2, 9 Delgrossi M.H.... le Bivic A. (1997)
    3. Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. (PubMed id 10080545)1, 2, 9 Martin-Martin B.... Mollinedo F. (1999)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells. (PubMed id 10788461)1, 9 Riento K....Olkkonen V.M. (2000)
    7. Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells. (PubMed id 9701566)1, 9 Riento K....Olkkonen V.M. (1998)
    8. Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3. (PubMed id 16598260)3, 9 Darios F. and Davletov B. (2006)
    9. A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. (PubMed id 9614185)1, 9 Galli T....Louvard D. (1998)
    10. Protease-activated receptor-1 activation of endotheli al cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. (PubMed id 15576373)1, 9 Fu J....Malik A.B. (2005)

    External Searches for STX3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing STX3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6809 HGNC: 11438 AceView: STX3AandOR10Y1P Ensembl:ENSG00000166900 euGenes: HUgn6809
    ECgene: STX3 Kegg: 6809 H-InvDB: STX3

    Other Databases showing STX3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STX3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STX3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for STX3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STX3 gene:
    Search GeneIP for patents involving STX3

    GeneCards and IP:
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