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Aliases for STX3 Gene

Aliases for STX3 Gene

  • Syntaxin 3 2 3 5
  • Syntaxin 3A 2 3
  • STX3A 3 4

External Ids for STX3 Gene

Previous HGNC Symbols for STX3 Gene

  • STX3A

Previous GeneCards Identifiers for STX3 Gene

  • GC11P059280
  • GC11P059522
  • GC11P055873
  • GC11P059480

Summaries for STX3 Gene

Entrez Gene Summary for STX3 Gene

  • The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for STX3 Gene

STX3 (Syntaxin 3) is a Protein Coding gene. Diseases associated with STX3 include Microvillus Inclusion Disease and Tetanus. Among its related pathways are Synaptic vesicle cycle and Immune System. GO annotations related to this gene include SNARE binding and arachidonic acid binding. An important paralog of this gene is STX1B.

UniProtKB/Swiss-Prot for STX3 Gene

  • Potentially involved in docking of synaptic vesicles at presynaptic active zones.

Gene Wiki entry for STX3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX3 Gene

Genomics for STX3 Gene

Regulatory Elements for STX3 Gene

Enhancers for STX3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STX3 on UCSC Golden Path with GeneCards custom track

Genomic Location for STX3 Gene

59,713,456 bp from pter
59,805,882 bp from pter
92,427 bases
Plus strand

Genomic View for STX3 Gene

Genes around STX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX3 Gene

Proteins for STX3 Gene

  • Protein details for STX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DME0
    • O43750
    • O43751
    • Q15360

    Protein attributes for STX3 Gene

    289 amino acids
    Molecular mass:
    33155 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STX3 Gene


neXtProt entry for STX3 Gene

Proteomics data for STX3 Gene at MOPED

Post-translational modifications for STX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for STX3 Gene

Domains & Families for STX3 Gene

Gene Families for STX3 Gene

Protein Domains for STX3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX3: view

Function for STX3 Gene

Molecular function for STX3 Gene

UniProtKB/Swiss-Prot Function:
Potentially involved in docking of synaptic vesicles at presynaptic active zones.
genes like me logo Genes that share phenotypes with STX3: view

Human Phenotype Ontology for STX3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for STX3 Gene

MGI Knock Outs for STX3:
  • Stx3 tm1.1(KOMP)Vlcg

Animal Model Products

miRNA for STX3 Gene

miRTarBase miRNAs that target STX3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for STX3 Gene

Localization for STX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX3 Gene

Membrane; Single-pass type IV membrane protein.

Subcellular locations from

Jensen Localization Image for STX3 Gene COMPARTMENTS Subcellular localization image for STX3 gene
Compartment Confidence
extracellular 5
lysosome 5
plasma membrane 5
vacuole 5
cytosol 4
golgi apparatus 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for STX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IDA,TAS --
GO:0008021 synaptic vesicle IBA --
GO:0016020 membrane IEA --
GO:0030027 lamellipodium IDA 21720706
genes like me logo Genes that share ontologies with STX3: view

Pathways & Interactions for STX3 Gene

genes like me logo Genes that share pathways with STX3: view

Pathways by source for STX3 Gene

1 BioSystems pathway for STX3 Gene
1 Qiagen pathway for STX3 Gene

Gene Ontology (GO) - Biological Process for STX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 21720706
GO:0016081 synaptic vesicle docking IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0045785 positive regulation of cell adhesion IMP 21720706
GO:0061025 membrane fusion IEA --
genes like me logo Genes that share ontologies with STX3: view

No data available for SIGNOR curated interactions for STX3 Gene

Drugs & Compounds for STX3 Gene

(3) Drugs for STX3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for STX3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STX3: view

Transcripts for STX3 Gene

Unigene Clusters for STX3 Gene

Syntaxin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STX3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - -
SP2: - - -
SP5: - -

Relevant External Links for STX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STX3 Gene

mRNA expression in normal human tissues for STX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STX3 Gene

This gene is overexpressed in Whole Blood (x8.9).

Protein differential expression in normal tissues from HIPED for STX3 Gene

This gene is overexpressed in Retina (23.6), Lavage (9.0), Milk (8.3), and Urine (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX3 Gene

SOURCE GeneReport for Unigene cluster for STX3 Gene Hs.180711

genes like me logo Genes that share expression patterns with STX3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for STX3 Gene

Orthologs for STX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for STX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STX3 35
  • 88.43 (n)
  • 95.83 (a)
STX3 36
  • 95 (a)
(Canis familiaris)
Mammalia STX3 35
  • 81.16 (n)
  • 91.7 (a)
STX3 36
  • 91 (a)
(Mus musculus)
Mammalia Stx3 35
  • 91.78 (n)
  • 98.26 (a)
Stx3 16
Stx3 36
  • 98 (a)
(Pan troglodytes)
Mammalia STX3 35
  • 99.42 (n)
  • 99.65 (a)
STX3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Stx3 35
  • 91.44 (n)
  • 98.26 (a)
(Monodelphis domestica)
Mammalia STX3 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia STX3 36
  • 90 (a)
(Gallus gallus)
Aves STX3 35
  • 76.59 (n)
  • 83.97 (a)
STX3 36
  • 80 (a)
(Anolis carolinensis)
Reptilia STX3 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14996 35
stx3 35
  • 72.61 (n)
  • 79.72 (a)
(Danio rerio)
Actinopterygii stx3a 35
  • 72.63 (n)
  • 76.49 (a)
zgc65954 35
STX3 (2 of 2) 36
  • 56 (a)
stx3a 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syx1A 36
  • 54 (a)
(Caenorhabditis elegans)
Secernentea unc-64 36
  • 53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for STX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX3 Gene

Gene Tree for STX3 (if available)
Gene Tree for STX3 (if available)

Paralogs for STX3 Gene

Paralogs for STX3 Gene

(11) SIMAP similar genes for STX3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STX3: view

Variants for STX3 Gene

Sequence variations from dbSNP and Humsavar for STX3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12282741 - 59,788,907(+) ACTGA(G/T)ATTAA reference, missense, utr-variant-5-prime
rs34563654 - 59,797,322(+) TGCTG(A/G)GCATT intron-variant, reference, missense
rs34753750 - 59,797,349(+) GACTT(C/T)CCGTT intron-variant, reference, missense
rs520851 -- 59,801,932(-) AAAAC(A/C)AGTTT intron-variant, utr-variant-3-prime
rs523016 -- 59,761,380(+) GTGGT(A/G)TATAC intron-variant

Variation tolerance for STX3 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STX3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for STX3 Gene

Disorders for STX3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for STX3 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
microvillus inclusion disease
  • diarrhea with microvillus atrophy 2
  • clostridial tetanus
- elite association - COSMIC cancer census association via MalaCards
Search STX3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STX3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with STX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STX3 Gene

Publications for STX3 Gene

  1. Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. (PMID: 16339081) Low S.H. … Weimbs T. (Mol. Biol. Cell 2006) 2 3 23 67
  2. The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome. (PMID: 19815536) Lee B.Y. … Horwitz M.A. (Mol. Cell Proteomics 2010) 3 23
  3. Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. (PMID: 17255364) Lapierre L.A. … Goldenring J.R. (Am. J. Physiol. Gastrointest. Liver Physiol. 2007) 3 23
  4. Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3. (PMID: 16598260) Darios F. … Davletov B. (Nature 2006) 2 23
  5. Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. (PMID: 15576373) Fu J. … Malik A.B. (J. Biol. Chem. 2005) 3 23

Products for STX3 Gene

Sources for STX3 Gene