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Aliases for STX2 Gene

Aliases for STX2 Gene

  • Syntaxin 2 2 3 5
  • Epimorphin 2 3 4
  • STX2A 3 4
  • STX2B 3 4
  • STX2C 3 4
  • EPIM 3 4
  • EPM 3

External Ids for STX2 Gene

Previous HGNC Symbols for STX2 Gene

  • STX2B
  • STX2C
  • STX2A
  • EPIM

Previous GeneCards Identifiers for STX2 Gene

  • GC12M129840
  • GC12M131274
  • GC12M128256

Summaries for STX2 Gene

Entrez Gene Summary for STX2 Gene

  • The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for STX2 Gene

STX2 (Syntaxin 2) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. GO annotations related to this gene include protein dimerization activity and SNARE binding. An important paralog of this gene is STX1B.

UniProtKB/Swiss-Prot for STX2 Gene

  • Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.

Gene Wiki entry for STX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX2 Gene

Genomics for STX2 Gene

Regulatory Elements for STX2 Gene

Promoters for STX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for STX2 Gene

Chromosome:
12
Start:
130,774,883 bp from pter
End:
130,839,274 bp from pter
Size:
64,392 bases
Orientation:
Minus strand

Genomic View for STX2 Gene

Genes around STX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX2 Gene

Proteins for STX2 Gene

  • Protein details for STX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32856-STX2_HUMAN
    Recommended name:
    Syntaxin-2
    Protein Accession:
    P32856
    Secondary Accessions:
    • Q86VW8

    Protein attributes for STX2 Gene

    Size:
    288 amino acids
    Molecular mass:
    33341 Da
    Quaternary structure:
    • Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent.
    SequenceCaution:
    • Sequence=BAA03436.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for STX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX2 Gene

Proteomics data for STX2 Gene at MOPED

Post-translational modifications for STX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STX2 Gene

Antibody Products

  • R&D Systems Antibodies for STX2 (Epimorphin/Syntaxin 2)

No data available for DME Specific Peptides for STX2 Gene

Domains & Families for STX2 Gene

Gene Families for STX2 Gene

Protein Domains for STX2 Gene

Suggested Antigen Peptide Sequences for STX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32856

UniProtKB/Swiss-Prot:

STX2_HUMAN :
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX2: view

Function for STX2 Gene

Molecular function for STX2 Gene

UniProtKB/Swiss-Prot Function:
Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.

LifeMap Function Summary for STX2 Gene

During embryonic development, STX2 as signaling molecule is secreted from the following cells
It affects the following cells:
genes like me logo Genes that share phenotypes with STX2: view

Animal Models for STX2 Gene

MGI Knock Outs for STX2:

Animal Model Products

  • Taconic Biosciences Mouse Models for STX2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STX2 Gene

Localization for STX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX2 Gene

Membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX2 Gene COMPARTMENTS Subcellular localization image for STX2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 4
cytoskeleton 2
golgi apparatus 2
nucleus 2
endoplasmic reticulum 1
endosome 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for STX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle IBA --
GO:0016021 integral component of membrane IEA,IBA --
GO:0016323 basolateral plasma membrane IDA 16339081
GO:0030027 lamellipodium IDA 21720706
GO:0030496 midbody IEA --
genes like me logo Genes that share ontologies with STX2: view

Pathways & Interactions for STX2 Gene

genes like me logo Genes that share pathways with STX2: view

Pathways by source for STX2 Gene

1 BioSystems pathway for STX2 Gene
1 Qiagen pathway for STX2 Gene

Gene Ontology (GO) - Biological Process for STX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007340 acrosome reaction IEA,ISS --
GO:0007398 ectoderm development TAS 8466509
GO:0009887 organ morphogenesis TAS 1581962
GO:0016192 vesicle-mediated transport IEA --
GO:0030033 microvillus assembly IEA --
genes like me logo Genes that share ontologies with STX2: view

No data available for SIGNOR curated interactions for STX2 Gene

Drugs & Compounds for STX2 Gene

(3) Drugs for STX2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for STX2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STX2: view

Transcripts for STX2 Gene

Unigene Clusters for STX2 Gene

Syntaxin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STX2 Gene

No ASD Table

Relevant External Links for STX2 Gene

GeneLoc Exon Structure for
STX2
ECgene alternative splicing isoforms for
STX2

Expression for STX2 Gene

mRNA expression in normal human tissues for STX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STX2 Gene

This gene is overexpressed in Spinal cord (20.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX2 Gene



SOURCE GeneReport for Unigene cluster for STX2 Gene Hs.437585

genes like me logo Genes that share expression patterns with STX2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for STX2 Gene

Orthologs for STX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for STX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STX2 35
  • 88.54 (n)
  • 93.75 (a)
STX2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STX2 35
  • 87.78 (n)
  • 91.46 (a)
STX2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stx2 35
  • 84.95 (n)
  • 89.58 (a)
Stx2 16
Stx2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STX2 35
  • 99.65 (n)
  • 99.65 (a)
STX2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stx2 35
  • 84.37 (n)
  • 88.54 (a)
oppossum
(Monodelphis domestica)
Mammalia STX2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX2 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves STX2 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15965 35
stx2 35
  • 73.05 (n)
  • 73.52 (a)
zebrafish
(Danio rerio)
Actinopterygii stx2b 35
  • 65.04 (n)
  • 64.81 (a)
stx2b 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Syx1A 36
  • 57 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-64 36
  • 52 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4995 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for STX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX2 Gene

ENSEMBL:
Gene Tree for STX2 (if available)
TreeFam:
Gene Tree for STX2 (if available)

Paralogs for STX2 Gene

Paralogs for STX2 Gene

(10) SIMAP similar genes for STX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STX2: view

Variants for STX2 Gene

Sequence variations from dbSNP and Humsavar for STX2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_014850 -
rs7301926 - 130,821,733(+) TTTTC(C/T)TTACT nc-transcript-variant, reference, missense
rs1236 -- 130,789,849(+) TCTAA(A/T)TACAA intron-variant, utr-variant-3-prime
rs8579 -- 130,790,045(-) CTCCA(C/G/T)GCCTC intron-variant, utr-variant-3-prime
rs13155 -- 130,790,939(-) ATTGG(C/T)TGCAA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for STX2 Gene

Variant ID Type Subtype PubMed ID
nsv939 CNV Insertion 18451855
nsv527536 CNV Loss 19592680

Variation tolerance for STX2 Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.94; 67.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STX2 Gene

HapMap Linkage Disequilibrium report
STX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX2 Gene

Disorders for STX2 Gene

Relevant External Links for STX2

Human Genome Epidemiology (HuGE) Navigator
STX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STX2

No disorders were found for STX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX2 Gene

Publications for STX2 Gene

  1. Localization of plasma membrane t-SNAREs syntaxin 2 and 3 in intracellular compartments. (PMID: 15943887) Band A.M. … Kuismanen E. (BMC Cell Biol. 2005) 2 3 23 67
  2. The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12. (PMID: 8938452) Zha H. … Wilder R.L. (Genomics 1996) 2 3 23
  3. Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis. (PMID: 19129200) Chen C.S. … Radisky D.C. (J. Biol. Chem. 2009) 3 23
  4. Overexpression of extracellular epimorphin leads to impaired epidermal differentiation in HaCaT keratinocytes. (PMID: 18273050) Okugawa Y. … Hirai Y. (J. Invest. Dermatol. 2008) 3 23
  5. SNAP-23 and syntaxin-2 localize to the extracellular surface of the platelet plasma membrane. (PMID: 17485553) Flaumenhaft R. … Dvorak A.M. (Blood 2007) 3 23

Products for STX2 Gene

Sources for STX2 Gene

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