Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

STX1B Gene

protein-coding GIFtS: 54
GCID: GC16M031000

syntaxin 1B

(Previous names: syntaxin 1B1, syntaxin 1B2 )
(Previous symbols: STX1B1, STX1B2)

Explore 7 diseases affiliated with
STX1B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Syntaxin 1B¹ ²		Syntaxin-1B¹
STX1B1¹ ² ³		Syntaxin-1B1³
STX1B2¹ ² ³		Syntaxin-1B2³
Syntaxin 1B1¹ ²		Syntaxin-1B1³
Syntaxin 1B2¹ ²		Syntaxin-1B2³
FP17469²

External Ids:	HGNC: 18539¹	Entrez Gene: 112755²	Ensembl: ENSG00000099365⁷	OMIM: 601485⁵	UniProtKB: P61266³

Export aliases for STX1B gene to outside databases

Previous GC identifers: GC16M030912 GC16M028563

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STX1B:

Syntaxins are cellular receptors for transport vesicles (see MIM 603765). One of these proteins, designated syntaxin 1B

(STX1B), is directly implicated in the process of calcium-dependent synaptic transmission in rat brain (Smirnova et

al., 1993 (PubMed 8105537)). The expression of this protein is transiently induced by long-term potentiation of

synaptic responses in the rat hippocampus. The protein may play an important role in the excitatory pathway of

synaptic transmission, which is known to be implicated in several neurologic diseases.(supplied by OMIM, Nov 2010)

UniProtKB/Swiss-Prot: STX1B_HUMAN, P61266

Function: Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate

Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)

Gene Wiki entry for STX1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the STX1B gene promoter:
STAT1 Sp1 RREB-1 Egr-1 NF-E2 p45 HNF-3beta MEF-2A ARP-1 aMEF-2 NF-E2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STX1B promoter sequence

Search SABiosciences Chromatin IP Primers for STX1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p12-p11

STX1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STX1B gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M031000: view genomic region (about GC identifiers)

Start:	31,000,577 bp from pter	End:	31,021,949 bp from pter
Size:	21,373 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STX1B_HUMAN, P61266 (See protein sequence)

Recommended Name: Syntaxin-1B

Size: 288 amino acids; 33245 Da

Subunit: Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent (By similarity)

Subcellular location: Membrane; Single-pass type IV membrane protein (Potential)

Secondary accessions: Q15531

Explore the universe of human proteins at neXtProt for STX1B: NX_P61266

Post-translational modifications:

Phosphorylated by CK2 (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P61266

STX1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_443106.1

ENSEMBL proteins:

ENSP00000215095 ENSP00000457067 ENSP00000455899

Reactome Protein details: P61266
Human Recombinant Protein Products for STX1B:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: STX1B OriGene Protein Over-expression Lysate: STX1B OriGene Custom Protein Services for STX1B
	GenScript Custom Purified and Recombinant Proteins Services for STX1B
	Novus Biologicals STX1B Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for STX1B

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005624	membrane fraction	--	--
GO:0005887	integral to plasma membrane	TAS	8105537
GO:0016020	membrane	--	--

STX1B for ontologies About GeneDecksing

STX1B Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for STX1B (Syntaxin 1B)
	Browse OriGene Antibodies OriGene Custom Antibody Services for STX1B
	GenScript Custom Superior Antibodies Services for STX1B
	Abcam antibodies for STX1B
	Uscn Antibodies for STX1B
	Search ThermoFisher Antibodies for STX1B

Assay Products for STX1B:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for STX1B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for STX1B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

STX1B for domains About GeneDecksing

5 InterPro domains/families:

IPR000727 T_SNARE_dom

IPR010989 t-SNARE

IPR006011 Syntaxin_N

IPR015709 Syntaxin-1

IPR006012 Syntaxin/epimorphin_CS

Graphical View of Domain Structure for InterPro Entry P61266

ProtoNet protein and cluster: P61266

1 Blocks protein family: IPB006011 Syntaxin

UniProtKB/Swiss-Prot: STX1B_HUMAN, P61266

Similarity: Belongs to the syntaxin family

Similarity: Contains 1 t-SNARE coiled-coil homology domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: STX1B_HUMAN, P61266

Function: Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate

Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)

Genatlas biochemistry entry for STX1B:

syntaxin 1B,brain,forming a synaptic core complex with synaptosome associated proteins,and synaptobrevin,binding to

N-type Ca2+ channels,involved in vesicular transport and in Ca2 dependent synaptic transmission,soluble N

ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005230	extracellular ligand-gated ion channel activity	TAS	8105537
GO:0005234	extracellular-glutamate-gated ion channel activity	TAS	8105537
GO:0005484	SNAP receptor activity	IEA	--
GO:0005515	protein binding	--	--
GO:0019904	protein domain specific binding	IEA	--

STX1B for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Stx1b):

behavior/neurological

endocrine/exocrine gland

mortality/aging

nervous system

no phenotypic analysis

STX1B for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for STX1B

miRNA Products:		OriGene 3'-UTR Clone: STX1B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STX1B
		8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate STX1B (see all 72):
		hsa-miR-4254 hsa-miR-574-3p hsa-miR-138-2* hsa-miR-3921 hsa-miR-629* hsa-miR-149 hsa-miR-637 hsa-miR-3116

		SwitchGear 3'UTR luciferase reporter plasmid: STX1B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STX1B (see all 4) OriGene shRNA RFP: STX1B OriGene siRNA: STX1B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX1B
		Sirion Biotech Custom design and validation of potent shRNA sequences against STX1B

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for STX1B
			Sirion Biotech Customized adenovirus for overexpression of STX1B Sirion Biotech Customized adenovirus for potent knockdown of STX1B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX1B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX1B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: STX1B (NM_052874)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for STX1B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX1B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for STX1B
		Search LifeMap BioReagents cell lines for STX1B
		Sirion Biotech Customized stable knockdown cell line services for STX1B Sirion Biotech Customized inducible knockdown cell line services for STX1B Sirion Biotech Customized stable overexpressing cell line services for STX1B Sirion Biotech Customized inducible overexpressing cell line services for STX1B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX1B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Botulinum neurotoxicity

Botulinum neurotoxicity

1.00

Proteolytic cleavage of SNARE complex proteins

0.89

Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

1.00

SNARE interactions in vesicular transport

0.40

Synaptic Vesicle Pathway

Synaptic Vesicle Pathway

1.00

Disease

Disease

1.00

Transmission across Chemical Synapses

Neuronal System

0.67

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for STX1B

Synaptic Vesicle Pathway

4 Reactome Pathways for STX1B

	Proteolytic cleavage of SNARE complex proteins
	Botulinum neurotoxicity
	Neuronal System
	Disease

1 PharmGKB Pathway for STX1B

Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

1 Kegg Pathway (Kegg details for STX1B):

SNARE interactions in vesicular transport

STX1B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for STX1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/37 Interacting proteins for STX1B (P61266³ ENSP00000215095⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 37)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STXBP1	P61764³, ENSP00000362399⁴	I2D: score=4 STRING: ENSP00000362399
VAMP7	P51809³, ENSP00000286448⁴	I2D: score=2 STRING: ENSP00000286448
VAMP2	P63027³, ENSP00000314214⁴	I2D: score=5 STRING: ENSP00000314214
SNAP23	O00161³, ENSP00000249647⁴	I2D: score=1 STRING: ENSP00000249647
UNC13B	O14795³, ENSP00000367756⁴	I2D: score=1 STRING: ENSP00000367756

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	8105537
GO:0006836	neurotransmitter transport	IEA	--
GO:0006886	intracellular protein transport	IEA	--
GO:0007268	synaptic transmission	IEA	--
GO:0015031	protein transport	--	--

STX1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for STX1B
Search CenterWatch for drugs/clinical trials and news about STX1B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for STX1B gene:

NM_052874.3

Unigene Cluster for STX1B:

Syntaxin 1B

Hs.542230 [show with all ESTs]

Unigene Representative Sequence: NM_052874

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000215095(uc010cad.2 uc010vfd.2) ENST00000569638 ENST00000565419

ENST00000566211 ENST00000561836

miRNA Products:		OriGene 3'-UTR Clone: STX1B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STX1B
		8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate STX1B (see all 72):
		hsa-miR-4254 hsa-miR-574-3p hsa-miR-138-2* hsa-miR-3921 hsa-miR-629* hsa-miR-149 hsa-miR-637 hsa-miR-3116

		SwitchGear 3'UTR luciferase reporter plasmid: STX1B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STX1B (see all 4) OriGene shRNA RFP: STX1B OriGene siRNA: STX1B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX1B
		Sirion Biotech Custom design and validation of potent shRNA sequences against STX1B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX1B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX1B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: STX1B (NM_052874)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for STX1B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX1B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STX1B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat STX1B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX1B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX1B

Additional cDNA sequence:

AK123137.1 AL713744.1 AL833259.1 AY028792.1 AY203924.1 AY995211.1 BC038359.1 BC062298.1

6 DOTS entries:

DT.92417128 DT.86846036 DT.100020849 DT.100836888 DT.445784 DT.102823499

24/63 AceView cDNA sequences (see all 63):

T33774 Z45823 BC062298 F04686 BQ940305 AW956912 AY028792 H18698

T33782 AL833259 BQ640507 BX422853 AY203924 AL713744 BG818056 AK123137

BF967282 NM_052874 R15454 H19537 Z45063 R89620 H18797 BC038359

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

STX1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTGTCCCC

About this image

STX1B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See STX1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STX1B

SOURCE GeneReport for Unigene cluster: Hs.542230

SABiosciences Custom PCR Arrays for STX1B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STX1B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat STX1B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX1B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX1B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX1B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX1B gene from 6/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	STX1B⁶	--	95(a)	1 ↔ 1	GL343220.1(1994677-2008615)
zebrafish (Danio rerio)	Actinopterygii	syntaxin1b²	syntaxin1b	82.34(n)		58038 AF229154.1
fruit fly (Drosophila melanogaster)	Insecta	Syx1A⁶	Syntaxin 1A	66(a)	1 → many	3R(19927322-19931465)
worm (Caenorhabditis elegans)	Secernentea	unc-64⁶	Syntaxin-1A homolog	58(a)	1 → many	III(13277160-13284263)
thale cress (Arabidopsis thaliana)	eudicotyledons	SYP123¹	syntaxin-123	42.48(n) 29.02(a)		827970 NM_116571.2 NP_192242.1
rice (Oryza sativa)	Liliopsida	Os02g0209900¹	hypothetical protein	47.09(n) 25.79(a)		9272269 NM_001185923.1 NP_001172852.1

ENSEMBL Gene Tree for STX1B (if available)
TreeFam Gene Tree for STX1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for STX1B gene

STX2² STX1A² STX11² STX3² STX19² STX4²

11 SIMAP similar genes for STX1B using alignment to 3 protein entries: STX1B_HUMAN (see all proteins):

STX1A stx1c STX2 DKFZp686L1857 STX3 STX3A

STX4A STX4 STX11 STX19 STX16

STX1B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4889605^1,2	C,F,A,H	--	31001095(+)	`GCGTGC/TGTCGA`	1	--	ut3¹		20		NA NS EA WA CSA	1313
rs146780994^1,2		--	31001166(+)	`GGGGAA/GGAGGA`	1	--	ut3¹		0	--	--	--	--
rs77218983^1,2	C,F	--	31001268(+)	`CACATT/CTGTCC`	1	--	ut3¹		1		NA	120
rs61738725^1,2	C,F	--	31001488(+)	`TCAACC/TCTTCT`	1	--	ut3¹		3		NS WA	186
rs188677275^1,2		--	31001756(+)	`CACAGA/GACAAG`	1	--	ut3¹		0	--	--	--	--
rs142978928^1,2		--	31001977(+)	`GCATGA/GCACAT`	1	--	ut3¹		0	--	--	--	--
rs117965846^1,2	C,F	--	31002064(+)	`NNNNAC/TCTACC`	1	--	ut3¹		1		NA	120
rs192489578^1,2		--	31002237(+)	`GACCCA/GGCCCA`	1	--	ut3¹		0	--	--	--	--
rs151103436^1,2		--	31002447(+)	`TTGCCG/TCATCA`	1	--	ut3¹		0	--	--	--	--
rs12932538^1,2	C,H	--	31002590(+)	`ACTGAG/AGGGTA`	1	--	ut3¹		4		NS EA	416

HapMap Linkage Disequilibrium report for STX1B (31000577 - 31021949 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for STX1B
2 CNVs: 4942 4941

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STX1B

DNA2.0 Custom Variant and Variant Library Synthesis for STX1B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

STX1B for disorders           About GeneDecksing

OMIM gene information: 601485    OMIM disorders: --

7 diseases for STX1B:    About MalaCards

hemolytic-uremic syndrome neurologic diseases burkitt's lymphoma diarrhea

hermaphroditism pancreatitis malaria

1 disease from the University of Copenhagen DISEASES database for STX1B:

hemolytic-uremic syndrome

Export disorders for STX1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for STX1B gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with STX1B)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)¹ Martins-de-Souza D....Bahn S. (2012)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Nuclear localization of a novel human syntaxin 1B isoform. (PubMed id 18691641)¹ Pereira S....Szepetowski P. (2008)
Huntingtin interacting proteins are genetic modifiers of neurodegeneration. (PubMed id 17500595)¹ Kaltenbach L.S....Hughes R.E. (2007)
Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis. (PubMed id 12651853)¹ Li G....Schwartz J.H. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay. (PubMed id 12093152)¹ Perez-Branguli F....Blasi J. (2002)
Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules. (PubMed id 11112705)¹ Nagamatsu S....Ishida H. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 112755	HGNC: 18539	AceView: STX1B2	Ensembl:ENSG00000099365	euGenes: HUgn112755
ECgene: STX1B	Kegg: 112755	H-InvDB: STX1B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for STX1B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for STX1B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for STX1B gene:
Search GeneIP for patents involving STX1B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for STX1B (Syntaxin 1B)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for STX1B
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STX1B		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STX1B
	OriGene Protein Over-expression Lysate for STX1B		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for STX1B		OriGene 3'-UTR Clone for STX1B
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX1B		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX1B
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for STX1B		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for STX1B		OriGene Custom Protein Services for STX1B
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STX1B
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STX1B
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX1B
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX1B
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX1B
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX1B

	GenScript Custom Purified and Recombinant Proteins Services for STX1B		GenScript cDNA clones with any tag delivered in your preferred vector for STX1B
	GenScript Custom Assay Services for STX1B		GenScript Custom Superior Antibodies Services for STX1B
	GenScript Custom overexpressing Cell Line Services for STX1B		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in STX1B promoter
	Search Chromatin IP Primers for STX1B
	RT² qPCR Primer Assay in human, mouse, rat STX1B
	Search GNC Networks for STX1B
	SABiosciences Custom PCR Arrays for STX1B

Search Tocris compounds for STX1B

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	STX1B lysates

	Antibodies for STX1B
	See all of Abcam's Antibodies, Kits and Proteins for STX1B
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

STX1B Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for STX1B

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX1B

	SwitchGear 3'UTR luciferase reporter plasmids for STX1B
	SwitchGear Promoter luciferase reporter plasmids for STX1B

Search ThermoFisher Antibodies for STX1B

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX1B

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for STX1B

Sirion Biotech Customized:

	stable knockdown cell line services for STX1B
	inducible knockdown cell line services for STX1B
	design and validation of potent shRNA sequences against STX1B
	adenovirus for potent knockdown of STX1B
	adenovirus for overexpression of STX1B
	stable overexpressing cell line services for STX1B
	inducible overexpressing cell line services for STX1B

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes STX1B gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

STX1B Gene

syntaxin 1B

Aliases
for STX1B gene

Summaries
for STX1B gene

Genomic Views
for STX1B gene

Proteins
for STX1B gene

Protein Domains /
Families
for STX1B gene

Function
for STX1B gene

Pathways & Interactions
for STX1B gene

Drugs & Compounds
for STX1B gene

Transcripts
for STX1B gene

Expression
for STX1B gene

Orthologs
for STX1B gene

Paralogs
for STX1B gene

Genomic Variants
for STX1B gene

Disorders / Diseases
for STX1B gene

Publications
for STX1B gene

External Searches for STX1B gene

Genome Databases showing STX1B gene

Other Databases showing STX1B gene

Specialized Databases showing STX1B gene

Intellectual Property
for STX1B gene

Products
for STX1B gene

View Random Gene

Advanced Search

Export list of displayed genes

STX1B Gene

syntaxin 1B

Aliasesfor STX1B gene

Summariesfor STX1B gene

Genomic Viewsfor STX1B gene

Proteinsfor STX1B gene

Protein Domains /Familiesfor STX1B gene

Functionfor STX1B gene

Pathways & Interactionsfor STX1B gene

Drugs & Compoundsfor STX1B gene

Transcriptsfor STX1B gene

Expression for STX1B gene

Orthologsfor STX1B gene

Paralogsfor STX1B gene

Genomic Variantsfor STX1B gene

Disorders / Diseasesfor STX1B gene

Publicationsfor STX1B gene

External Searches for STX1B gene

Genome Databases showing STX1B gene

Other Databases showing STX1B gene

Specialized Databases showing STX1B gene

Intellectual Propertyfor STX1B gene

Productsfor STX1B gene

View Random Gene

Aliases
for STX1B gene

Summaries
for STX1B gene

Genomic Views
for STX1B gene

Proteins
for STX1B gene

Protein Domains /
Families
for STX1B gene

Function
for STX1B gene

Pathways & Interactions
for STX1B gene

Drugs & Compounds
for STX1B gene

Transcripts
for STX1B gene

Expression
for STX1B gene

Orthologs
for STX1B gene

Paralogs
for STX1B gene

Genomic Variants
for STX1B gene

Disorders / Diseases
for STX1B gene

Publications
for STX1B gene

Intellectual Property
for STX1B gene

Products
for STX1B gene