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Aliases for STX19 Gene

Aliases for STX19 Gene

  • Syntaxin 19 2 3 5
  • Syntaxin-19 3

External Ids for STX19 Gene

Previous GeneCards Identifiers for STX19 Gene

  • GC03U900602
  • GC03M095217
  • GC03M093733
  • GC03M091095

Summaries for STX19 Gene

GeneCards Summary for STX19 Gene

STX19 (Syntaxin 19) is a Protein Coding gene. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is STX11.

Additional gene information for STX19 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX19 Gene

Genomics for STX19 Gene

GeneHancer (GH) Regulatory Elements for STX19 Gene

Promoters and enhancers for STX19 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I094028 Promoter/Enhancer 1.1 EPDnew ENCODE 550.8 +0.2 154 0.1 SMARCE1 DPF2 ELF1 ZBTB40 ZNF217 GATA3 JUND CTBP1 STX19 HMGN1P7 ARL13B
GH03I094061 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 8.3 -34.6 -34572 2.9 HDGF CLOCK SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF143 DHFR2 NSUN3 STX19
GH03I093843 Enhancer 0.8 Ensembl ENCODE 11.6 +184.6 184592 1.7 JUN FOSL1 MITF ZFHX2 CTBP1 JUND EGR1 GLIS1 FOS ZBTB17 RNU6-488P STX19 PROS1 PIR37198
GH03I094332 Enhancer 0.6 VISTA 8.2 -304.8 -304804 2.8 CTBP1 GATA3 FOXA1 STX19 PROS1 GC03P094366 GC03M094207
GH03I094412 Enhancer 0.4 ENCODE 7.1 -384.6 -384591 1.8 CEBPB EP300 BRCA1 STX19 GC03P094387 ARMC10P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STX19 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STX19 gene promoter:

Genomic Locations for STX19 Gene

Genomic Locations for STX19 Gene
14,412 bases
Minus strand

Genomic View for STX19 Gene

Genes around STX19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX19 Gene

Proteins for STX19 Gene

  • Protein details for STX19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for STX19 Gene

    294 amino acids
    Molecular mass:
    34324 Da
    Quaternary structure:
    No Data Available

neXtProt entry for STX19 Gene

Post-translational modifications for STX19 Gene

No Post-translational modifications

Other Protein References for STX19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STX19 Gene

Domains & Families for STX19 Gene

Gene Families for STX19 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STX19 Gene

Suggested Antigen Peptide Sequences for STX19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the syntaxin family.
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX19: view

Function for STX19 Gene

Gene Ontology (GO) - Molecular Function for STX19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with STX19: view
genes like me logo Genes that share phenotypes with STX19: view

Animal Models for STX19 Gene

MGI Knock Outs for STX19:

Animal Model Products

CRISPR Products

miRNA for STX19 Gene

miRTarBase miRNAs that target STX19

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STX19 Gene

Localization for STX19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX19 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STX19 gene
Compartment Confidence
plasma membrane 3
cytosol 3
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STX19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0008021 synaptic vesicle IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
GO:0031201 SNARE complex IBA --
genes like me logo Genes that share ontologies with STX19: view

Pathways & Interactions for STX19 Gene

genes like me logo Genes that share pathways with STX19: view

Pathways by source for STX19 Gene

1 KEGG pathway for STX19 Gene

Gene Ontology (GO) - Biological Process for STX19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0016192 vesicle-mediated transport IEA --
GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane IBA --
GO:0048278 vesicle docking IBA --
genes like me logo Genes that share ontologies with STX19: view

No data available for SIGNOR curated interactions for STX19 Gene

Drugs & Compounds for STX19 Gene

No Compound Related Data Available

Transcripts for STX19 Gene

mRNA/cDNA for STX19 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for STX19 Gene

Syntaxin 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX19 Gene

No ASD Table

Relevant External Links for STX19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STX19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STX19 Gene

mRNA differential expression in normal tissues according to GTEx for STX19 Gene

This gene is overexpressed in Colon - Transverse (x9.5), Esophagus - Mucosa (x6.5), Pancreas (x4.9), Minor Salivary Gland (x4.7), and Stomach (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of STX19 Gene:


SOURCE GeneReport for Unigene cluster for STX19 Gene:


Evidence on tissue expression from TISSUES for STX19 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with STX19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STX19 Gene

Orthologs for STX19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STX19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STX19 33 34
  • 99.77 (n)
(Canis familiaris)
Mammalia STX19 33 34
  • 92.29 (n)
(Bos Taurus)
Mammalia STX19 33 34
  • 91.23 (n)
(Mus musculus)
Mammalia Stx19 33 16 34
  • 85.27 (n)
(Rattus norvegicus)
Mammalia Stx19 33
  • 84.93 (n)
(Ornithorhynchus anatinus)
Mammalia STX19 34
  • 78 (a)
(Gallus gallus)
Aves STX19 33 34
  • 68.66 (n)
(Anolis carolinensis)
Reptilia STX19 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stx19 33
  • 64.78 (n)
(Danio rerio)
Actinopterygii LOC570366 33
  • 55.59 (n)
CT573248.1 34
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syx4 34
  • 14 (a)
(Caenorhabditis elegans)
Secernentea syx-3 34
  • 20 (a)
syx-4 34
  • 18 (a)
syx-2 34
  • 17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSO1 34
  • 16 (a)
SSO2 34
  • 16 (a)
Species where no ortholog for STX19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX19 Gene

Gene Tree for STX19 (if available)
Gene Tree for STX19 (if available)

Paralogs for STX19 Gene

Paralogs for STX19 Gene

(9) SIMAP similar genes for STX19 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STX19: view

Variants for STX19 Gene

Sequence variations from dbSNP and Humsavar for STX19 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000135023 -- 94,016,935(-) G/A intron_variant
rs1000217913 -- 94,026,304(-) T/G intron_variant
rs1000486203 -- 94,017,303(-) G/A intron_variant
rs1000600441 -- 94,020,456(-) C/A intron_variant
rs1000754263 -- 94,026,625(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STX19 Gene

Variant ID Type Subtype PubMed ID
dgv4814n100 CNV gain 25217958
esv3893746 CNV loss 25118596
nsv590987 CNV loss 21841781

Variation tolerance for STX19 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STX19 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX19 Gene

Disorders for STX19 Gene

Additional Disease Information for STX19

No disorders were found for STX19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX19 Gene

Publications for STX19 Gene

  1. A targeted siRNA screen to identify SNAREs required for constitutive secretion in mammalian cells. (PMID: 20545907) Gordon DE … Peden AA (Traffic (Copenhagen, Denmark) 2010) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 58
  5. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N … Vidal M (Cell 2015) 3 58

Products for STX19 Gene

Sources for STX19 Gene

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