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Aliases for STX18 Gene

Aliases for STX18 Gene

  • Syntaxin 18 2 3 5
  • Cell Growth-Inhibiting Gene 9 Protein 3 4
  • Ufe1 3

External Ids for STX18 Gene

Previous GeneCards Identifiers for STX18 Gene

  • GC04M004307
  • GC04M004466
  • GC04M004485
  • GC04M004538

Summaries for STX18 Gene

GeneCards Summary for STX18 Gene

STX18 (Syntaxin 18) is a Protein Coding gene. Among its related pathways are Phagosome and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. GO annotations related to this gene include protein domain specific binding and SNAP receptor activity.

UniProtKB/Swiss-Prot for STX18 Gene

  • Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX18 Gene

Genomics for STX18 Gene

Regulatory Elements for STX18 Gene

Enhancers for STX18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STX18 on UCSC Golden Path with GeneCards custom track

Promoters for STX18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STX18 on UCSC Golden Path with GeneCards custom track

Genomic Location for STX18 Gene

Chromosome:
4
Start:
4,415,742 bp from pter
End:
4,542,346 bp from pter
Size:
126,605 bases
Orientation:
Minus strand

Genomic View for STX18 Gene

Genes around STX18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX18 Gene

Proteins for STX18 Gene

  • Protein details for STX18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2W9-STX18_HUMAN
    Recommended name:
    Syntaxin-18
    Protein Accession:
    Q9P2W9
    Secondary Accessions:
    • Q596L3
    • Q5TZP5

    Protein attributes for STX18 Gene

    Size:
    335 amino acids
    Molecular mass:
    38674 Da
    Quaternary structure:
    • Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 are associated with the complex through interaction with BNIP1/SEC20L. Interacts directly with USE1L and BNIP1/SEC20L.

neXtProt entry for STX18 Gene

Proteomics data for STX18 Gene at MOPED

Post-translational modifications for STX18 Gene

  • Ubiquitination at Lys 143
  • Modification sites at PhosphoSitePlus

Other Protein References for STX18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STX18 Gene

Domains & Families for STX18 Gene

Gene Families for STX18 Gene

Protein Domains for STX18 Gene

Suggested Antigen Peptide Sequences for STX18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2W9

UniProtKB/Swiss-Prot:

STX18_HUMAN :
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX18: view

Function for STX18 Gene

Molecular function for STX18 Gene

UniProtKB/Swiss-Prot Function:
Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
genes like me logo Genes that share phenotypes with STX18: view

Animal Model Products

miRNA for STX18 Gene

miRTarBase miRNAs that target STX18

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STX18 Gene

Localization for STX18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX18 Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX18 Gene COMPARTMENTS Subcellular localization image for STX18 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 4
plasma membrane 3
peroxisome 2
cytosol 1
endosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for STX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with STX18: view

Pathways & Interactions for STX18 Gene

genes like me logo Genes that share pathways with STX18: view

Gene Ontology (GO) - Biological Process for STX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061025 membrane fusion IEA --
GO:1902117 positive regulation of organelle assembly IMP 19401338
genes like me logo Genes that share ontologies with STX18: view

No data available for SIGNOR curated interactions for STX18 Gene

Drugs & Compounds for STX18 Gene

No Compound Related Data Available

Transcripts for STX18 Gene

Unigene Clusters for STX18 Gene

Syntaxin 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STX18 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b
SP1: - - - - - - -
SP2: - -
SP3: -
SP4:
SP5:

Relevant External Links for STX18 Gene

GeneLoc Exon Structure for
STX18
ECgene alternative splicing isoforms for
STX18

Expression for STX18 Gene

mRNA expression in normal human tissues for STX18 Gene

Protein differential expression in normal tissues from HIPED for STX18 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.9), Pancreas (11.5), and Bone (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX18 Gene



SOURCE GeneReport for Unigene cluster for STX18 Gene Hs.584913

mRNA Expression by UniProt/SwissProt for STX18 Gene

Q9P2W9-STX18_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with STX18: view

Protein tissue co-expression partners for STX18 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for STX18 Gene

Orthologs for STX18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX18 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STX18 35
  • 89.25 (n)
  • 93.43 (a)
STX18 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STX18 35
  • 91.84 (n)
  • 94.63 (a)
STX18 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stx18 35
  • 88.92 (n)
  • 92.81 (a)
Stx18 16
Stx18 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STX18 35
  • 99.6 (n)
  • 99.7 (a)
rat
(Rattus norvegicus)
Mammalia Stx18 35
  • 88.42 (n)
  • 93.11 (a)
oppossum
(Monodelphis domestica)
Mammalia STX18 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX18 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves STX18 35
  • 78.71 (n)
  • 81.93 (a)
STX18 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX18 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9979 35
stx18 35
  • 72.36 (n)
  • 75.91 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4342 35
zebrafish
(Danio rerio)
Actinopterygii Dr.19719 35
stx18 35
  • 68.48 (n)
  • 75.08 (a)
CABZ01086801.1 36
  • 66 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1004 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011160 35
  • 47.69 (n)
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syx18 35
  • 59.7 (n)
  • 55.45 (a)
Syx18 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea syx-18 36
  • 19 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons SYP81 35
  • 44.63 (n)
  • 31.84 (a)
rice
(Oryza sativa)
Liliopsida Os04g0530400 35
  • 48.02 (n)
  • 34.13 (a)
Species with no ortholog for STX18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX18 Gene

ENSEMBL:
Gene Tree for STX18 (if available)
TreeFam:
Gene Tree for STX18 (if available)

Paralogs for STX18 Gene

Pseudogenes.org Pseudogenes for STX18 Gene

genes like me logo Genes that share paralogs with STX18: view

No data available for Paralogs for STX18 Gene

Variants for STX18 Gene

Sequence variations from dbSNP and Humsavar for STX18 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_052250 -
VAR_052251 -
rs33952588 - 4,434,790(+) TGGGG(A/T)TAACT nc-transcript-variant, reference, missense, stop-gained
rs14679 -- 4,419,702(+) TCTTG(A/C)GGCCT nc-transcript-variant, utr-variant-3-prime
rs689484 -- 4,520,888(+) ATGTT(G/T)AAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STX18 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
nsv528931 CNV Gain 19592680
nsv521279 CNV Loss 19592680

Variation tolerance for STX18 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.51; 71.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STX18 Gene

HapMap Linkage Disequilibrium report
STX18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX18 Gene

Disorders for STX18 Gene

Relevant External Links for STX18

Genetic Association Database (GAD)
STX18
Human Genome Epidemiology (HuGE) Navigator
STX18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STX18

No disorders were found for STX18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX18 Gene

Publications for STX18 Gene

  1. Syntaxin 18, a SNAP receptor that functions in the endoplasmic reticulum, intermediate compartment, and cis-Golgi vesicle trafficking. (PMID: 10788491) Hatsuzawa K. … Tagaya M. (J. Biol. Chem. 2000) 2 3 4 67
  2. Role of syntaxin 18 in the organization of endoplasmic reticulum subdomains. (PMID: 19401338) Iinuma T. … Tani K. (J. Cell. Sci. 2009) 3 23
  3. RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex. (PMID: 16571679) Arasaki K. … Tagaya M. (Mol. Biol. Cell 2006) 3 23
  4. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. (PMID: 15029241) Hirose H. … Tagaya M. (EMBO J. 2004) 3 23
  5. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PMID: 15272311) Nakajima K. … Tagaya M. (EMBO J. 2004) 3 23

Products for STX18 Gene

Sources for STX18 Gene

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