STX18 Gene
protein-coding GIFtS: 51
GCID: GC04M004417
|
|
syntaxin 18
| |
Aliases
for STX18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Syntaxin 181 2 | | Ufe11 2 | | Cell Growth-Inhibiting Gene 9 Protein2 3 | | Syntaxin-181 |
Export aliases for STX18 gene to outside databasesPrevious GC identifers: GC04M004307 GC04M004466 GC04M004485 GC04M004538 |
Summaries
for STX18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: STX18_HUMAN, Q9P2W9Function: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with theER
|
Genomic Views
for STX18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006051.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STX18 gene promoter:
AML1a p300 XBP-1 IRF-1 AREB6 MEF-2A SRY FOXC1 NRF-2 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for STX18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.3-p16.2 Ensembl cytogenetic band: 4p16.2 HGNC chromosome: 4STX18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M004417: view genomic region
(about GC identifiers)
Start:
|
4,417,469 bp from pter |
End:
|
4,544,073 bp from pter |
Size:
|
126,605 bases |
Orientation:
|
minus strand |
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Proteins
for STX18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STX18_HUMAN, Q9P2W9 (See
protein sequence)Recommended Name: Syntaxin-18 Size: 335 amino acids; 38674 Da
Subunit: Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 areassociated with the complex through interaction with BNIP1/SEC20L. Interacts directly with USE1L and BNIP1/SEC20L
Subcellular location: Endoplasmic reticulum membrane; Single-pass type IV membrane protein (Probable). Golgi apparatusmembrane; Single-pass type IV membrane protein (Potential)
Secondary accessions: Q596L3 Q5TZP5Explore the universe of human proteins at neXtProt for STX18: NX_Q9P2W9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P2W9
STX18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_058626.1
ENSEMBL proteins: ENSP00000426648 ENSP00000305810 ENSP00000427543 ENSP00000425483 ENSP00000422376
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
STX18 for ontologies About GeneDecksing
STX18 Antibody Products:
Assay Products for STX18: |
Protein
Domains /
Families
for STX18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STX18 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P2W9ProtoNet protein and cluster: Q9P2W9 UniProtKB/Swiss-Prot: STX18_HUMAN, Q9P2W9Similarity: Belongs to the syntaxin familySimilarity: Contains 1 t-SNARE coiled-coil homology domain |
Function
for STX18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STX18_HUMAN, Q9P2W9Function: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with theER
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX18 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX18
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: STX18 (NM_016930) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STX18 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX18 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX18 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
STX18 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for STX18:
|
Pathways & Interactions
for STX18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics | | | 2 | Phagosome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  PharmGKB Pathway for STX18
2 
Kegg Pathways (Kegg details for STX18):
STX18 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STX18
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/33 Interacting proteins for STX18 (Q9P2W92, 3 ENSP000003058104) via UniProtKB, MINT, STRING, and/or I2D (see all 33)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006886 | intracellular protein transport |
IEA | -- | | GO:0006888 | ER to Golgi vesicle-mediated transport |
TAS | 10788491 |
STX18 for ontologies About GeneDecksing
|
Drugs & Compounds
for STX18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STX18
Search CenterWatch for drugs/clinical trials and news about STX18
|
Transcripts
for STX18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STX18 gene: NM_016930.2 Unigene Cluster for STX18: Syntaxin 18 Hs.584913 [show with all ESTs]Unigene Representative Sequence: BX64708310 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000505286 ENST00000503692 ENST00000306200(uc003gic.3) ENST00000515687
ENST00000503861 ENST00000502267 ENST00000510296 ENST00000512195 ENST00000507908
ENST00000512780
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX18 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX18
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STX18 (NM_016930) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STX18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX18 |
Additional cDNA sequence: AB028741.1 AK310026.1 AL832867.1 AY453396.1 BC014613.2 BC071980.1 BT007150.1 BT020135.1 BX647083.1 14 DOTS entries: DT.313727 DT.95351133 DT.100019693 DT.101984578 DT.120992228 DT.91758914 DT.95339438 DT.100780616 DT.433462 DT.86845285 DT.95077376 DT.95282827 DT.97858407 DT.100706055 24/160 AceView cDNA sequences (see all 160): AI188109 BU690010 AI565091 BM975444 AW351904 CB158507 BF725048 BC071980 AW472978 CR609491 BQ941902 CF128472 BT007150 AA383715 AA350367 CB852045 BQ775409 BC014613 BM478232 AL832867 AI497875 NM_016930 AI205277 CA425555
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for STX18 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | - | | - | | - | | | | | | | | | | | | | | - | | | | - | | - | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for STX18
|
Expression
for STX18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STX18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTATGACCAG
About this image
See STX18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STX18
SOURCE GeneReport for Unigene cluster: Hs.584913
UniProtKB/Swiss-Prot: STX18_HUMAN, Q9P2W9Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for STX18
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STX18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STX18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX18 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX18 |
Orthologs
for STX18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for STX18 gene from 9/25 species (see all 25) About this table
ENSEMBL Gene Tree for STX18 (if available)
TreeFam Gene Tree for STX18 (if available) |
Paralogs
for STX18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STX18 gene
STX18 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for STX18
PGOHUM00000237342
|
Genomic Variants
for STX18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STX18 |
|
Disorders
/ Diseases
for STX18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STX18 for disorders About GeneDecksing
OMIM gene information: 606046
OMIM disorders: --
2  diseases for STX18: About MalaCardsbreast cancer schizophrenia
Human Genome Epidemiology (HuGE) Navigator: STX18 (3 documents)
Export disorders for STX18 gene to outside databases
|
Publications
for STX18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STX18 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with STX18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Syntaxin 18, a SNAP receptor that functions in the endoplasmic reticulum, intermediate compartment, and cis-Golgi vesicle trafficking. (PubMed id 10788491)1, 2, 3 Hatsuzawa K....Tagaya M. (2000)
- Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. (PubMed id 15029241)1, 2, 9 Hirose H.... Tagaya M. (2004)
- Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PubMed id 15272311)1, 2, 9 Nakajima K.... Tagaya M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Role of syntaxin 18 in the organization of endoplasmic reticulum subdomains. (PubMed id 19401338)1, 9 Iinuma T....Tani K. (2009)
- RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex. (PubMed id 16571679)1, 9 Arasaki K....Tagaya M. (2006)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
|
External Searches for STX18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STX18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STX18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STX18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STX18 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STX18 gene:
Search GeneIP for patents involving STX18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STX18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for STX18 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STX18 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STX18 | | | OriGene Protein Over-expression Lysate for STX18 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STX18 | | OriGene 3'-UTR Clone for STX18 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX18 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX18 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for STX18 | | OriGene Custom Protein Services for STX18 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STX18 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STX18 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX18 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX18 |
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| |  |  |  |  | | | | |
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 | | | STX18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX18 |
|  |  |  | | | | Search ThermoFisher Antibodies for STX18 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX18 |
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