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Aliases for STX18 Gene

Aliases for STX18 Gene

  • Syntaxin 18 2 3
  • Cell Growth-Inhibiting Gene 9 Protein 3 4
  • Syntaxin-18 3
  • Ufe1 3

External Ids for STX18 Gene

Previous GeneCards Identifiers for STX18 Gene

  • GC04M004307
  • GC04M004466
  • GC04M004485
  • GC04M004538

Summaries for STX18 Gene

GeneCards Summary for STX18 Gene

STX18 (Syntaxin 18) is a Protein Coding gene. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Phagosome. GO annotations related to this gene include SNAP receptor activity.

UniProtKB/Swiss-Prot for STX18 Gene

  • Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX18 Gene

Genomics for STX18 Gene

Regulatory Elements for STX18 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STX18 Gene

4,415,742 bp from pter
4,542,346 bp from pter
126,605 bases
Minus strand

Genomic View for STX18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STX18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX18 Gene

Proteins for STX18 Gene

  • Protein details for STX18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q596L3
    • Q5TZP5

    Protein attributes for STX18 Gene

    335 amino acids
    Molecular mass:
    38674 Da
    Quaternary structure:
    • Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 are associated with the complex through interaction with BNIP1/SEC20L. Interacts directly with USE1L and BNIP1/SEC20L.

neXtProt entry for STX18 Gene

Proteomics data for STX18 Gene at MOPED

Post-translational modifications for STX18 Gene

  • Ubiquitination at Lys143
  • Modification sites at PhosphoSitePlus

Other Protein References for STX18 Gene

No data available for DME Specific Peptides for STX18 Gene

Domains for STX18 Gene

Protein Domains for STX18 Gene

Suggested Antigen Peptide Sequences for STX18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9P2W9
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX18: view

No data available for Gene Families for STX18 Gene

Function for STX18 Gene

Molecular function for STX18 Gene

UniProtKB/Swiss-Prot Function: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

Gene Ontology (GO) - Molecular Function for STX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 15029241
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with STX18: view

Phenotypes for STX18 Gene

GenomeRNAi human phenotypes for STX18:
genes like me logo Genes that share phenotypes with STX18: view

Animal Model Products

miRNA for STX18 Gene

miRTarBase miRNAs that target STX18

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for STX18 Gene

Localization for STX18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX18 Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein.

Subcellular locations from

Jensen Localization Image for STX18 Gene COMPARTMENTS Subcellular localization image for STX18 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
peroxisome 2
cytosol 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for STX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IDA 10788491
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with STX18: view

Pathways for STX18 Gene

genes like me logo Genes that share pathways with STX18: view

Pathways by source for STX18 Gene

Gene Ontology (GO) - Biological Process for STX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IBA --
GO:0061025 membrane fusion IEA --
GO:0090158 endoplasmic reticulum membrane organization IMP 19401338
genes like me logo Genes that share ontologies with STX18: view

Transcripts for STX18 Gene

Unigene Clusters for STX18 Gene

Syntaxin 18:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STX18

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX18 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b
SP1: - - - - - - -
SP2: - -
SP3: -

Relevant External Links for STX18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STX18 Gene

mRNA expression in normal human tissues for STX18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX18 Gene

SOURCE GeneReport for Unigene cluster for STX18 Gene Hs.584913

mRNA Expression by UniProt/SwissProt for STX18 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with STX18: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for STX18 Gene

Orthologs for STX18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STX18 35
  • 99.6 (n)
  • 99.7 (a)
(Bos Taurus)
Mammalia STX18 35
  • 89.25 (n)
  • 93.43 (a)
STX18 36
  • 93 (a)
(Canis familiaris)
Mammalia STX18 35
  • 91.84 (n)
  • 94.63 (a)
STX18 36
  • 95 (a)
(Mus musculus)
Mammalia Stx18 35
  • 88.92 (n)
  • 92.81 (a)
Stx18 16
Stx18 36
  • 93 (a)
(Monodelphis domestica)
Mammalia STX18 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia STX18 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Stx18 35
  • 88.42 (n)
  • 93.11 (a)
(Gallus gallus)
Aves STX18 35
  • 78.71 (n)
  • 81.93 (a)
STX18 36
  • 81 (a)
(Anolis carolinensis)
Reptilia STX18 36
  • 77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4342 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9979 35
stx18 35
  • 72.36 (n)
  • 75.91 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1004 35
(Danio rerio)
Actinopterygii CABZ01086801.1 36
  • 66 (a)
Dr.19719 35
stx18 35
  • 68.48 (n)
  • 75.08 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011160 35
  • 47.69 (n)
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syx18 35
  • 59.7 (n)
  • 55.45 (a)
Syx18 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea syx-18 36
  • 19 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SYP81 35
  • 44.63 (n)
  • 31.84 (a)
(Oryza sativa)
Liliopsida Os04g0530400 35
  • 48.02 (n)
  • 34.13 (a)
Species with no ortholog for STX18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX18 Gene

Gene Tree for STX18 (if available)
Gene Tree for STX18 (if available)

Paralogs for STX18 Gene Pseudogenes for STX18 Gene

genes like me logo Genes that share paralogs with STX18: view

No data available for Paralogs for STX18 Gene

Variants for STX18 Gene

Sequence variations from dbSNP and Humsavar for STX18 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs14679 -- 4,419,702(+) TCTTG(A/C)GGCCT utr-variant-3-prime, nc-transcript-variant
rs689484 -- 4,520,888(+) ATGTT(G/T)AAGAC intron-variant
rs1080314 -- 4,504,767(-) TTAAT(A/C)GGTGT intron-variant
rs1372096 -- 4,521,001(+) GATGA(A/T)AAACA intron-variant
rs1441085 -- 4,488,969(+) GCTTG(A/T)CAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STX18 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
nsv528931 CNV Gain 19592680
nsv521279 CNV Loss 19592680

Relevant External Links for STX18 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX18 Gene

Disorders for STX18 Gene

Relevant External Links for STX18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with STX18: view

No data available for UniProtKB/Swiss-Prot for STX18 Gene

Publications for STX18 Gene

  1. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. (PMID: 15029241) Hirose H. … Tagaya M. (EMBO J. 2004) 3 4 23
  2. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PMID: 15272311) Nakajima K. … Tagaya M. (EMBO J. 2004) 3 4 23
  3. Syntaxin 18, a SNAP receptor that functions in the endoplasmic reticulum, intermediate compartment, and cis-Golgi vesicle trafficking. (PMID: 10788491) Hatsuzawa K. … Tagaya M. (J. Biol. Chem. 2000) 2 3 4
  4. Role of syntaxin 18 in the organization of endoplasmic reticulum subdomains. (PMID: 19401338) Iinuma T. … Tani K. (J. Cell. Sci. 2009) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for STX18 Gene

Sources for STX18 Gene

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