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Aliases for STX17 Gene

Aliases for STX17 Gene

  • Syntaxin 17 2 3 5

External Ids for STX17 Gene

Previous GeneCards Identifiers for STX17 Gene

  • GC00U990459
  • GC09P098048
  • GC09P099748
  • GC09P101708
  • GC09P102668
  • GC09P072267

Summaries for STX17 Gene

GeneCards Summary for STX17 Gene

STX17 (Syntaxin 17) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. GO annotations related to this gene include protein kinase binding and SNARE binding.

UniProtKB/Swiss-Prot for STX17 Gene

  • SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX17 Gene

Genomics for STX17 Gene

Regulatory Elements for STX17 Gene

Promoters for STX17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STX17 on UCSC Golden Path with GeneCards custom track

Genomic Location for STX17 Gene

Chromosome:
9
Start:
99,906,633 bp from pter
End:
99,979,337 bp from pter
Size:
72,705 bases
Orientation:
Plus strand

Genomic View for STX17 Gene

Genes around STX17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX17 Gene

Proteins for STX17 Gene

  • Protein details for STX17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56962-STX17_HUMAN
    Recommended name:
    Syntaxin-17
    Protein Accession:
    P56962
    Secondary Accessions:
    • Q4VXC2

    Protein attributes for STX17 Gene

    Size:
    302 amino acids
    Molecular mass:
    33403 Da
    Quaternary structure:
    • Forms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with lysosome (PubMed:23217709, PubMed:25686604). Interacts with VAMP7 and VTI1B (PubMed:23217709). Probably interacts with BET1, SCFD1 and SEC22B (By similarity). Interacts with PTPN2 and ABL1; involved in STX17 phosphorylation (PubMed:23006999). Interacts with COPB1 (By similarity). Interacts with TMED9 and TMED10; the interaction is direct (PubMed:21545355). Interacts with ATG14 (PubMed:25686604).

    Three dimensional structures from OCA and Proteopedia for STX17 Gene

neXtProt entry for STX17 Gene

Proteomics data for STX17 Gene at MOPED

Post-translational modifications for STX17 Gene

  • Phosphorylated at Tyr-157 probably by ABL1. Dephosphorylation by PTPN2; regulates exit from the endoplasmic reticulum (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STX17 Gene

Domains & Families for STX17 Gene

Gene Families for STX17 Gene

Protein Domains for STX17 Gene

Suggested Antigen Peptide Sequences for STX17 Gene

Graphical View of Domain Structure for InterPro Entry

P56962

UniProtKB/Swiss-Prot:

STX17_HUMAN :
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX17: view

Function for STX17 Gene

Molecular function for STX17 Gene

UniProtKB/Swiss-Prot Function:
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355).
genes like me logo Genes that share phenotypes with STX17: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STX17 Gene

Localization for STX17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX17 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Smooth endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Cytoplasm, cytosol. Note=Has an hairpin-like insertion into membranes. Localizes to the completed autophagosome membrane upon cell starvation (PubMed:23217709). May also localize to the mitochondria according to PubMed:23217709. {ECO:0000269 PubMed:23217709}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX17 Gene COMPARTMENTS Subcellular localization image for STX17 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
mitochondrion 5
vacuole 5
endosome 2
lysosome 2
nucleus 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IDA 23217709
GO:0005737 cytoplasm IEA --
GO:0005765 NOT lysosomal membrane IDA 10930465
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 23006999
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with STX17: view

Pathways & Interactions for STX17 Gene

genes like me logo Genes that share pathways with STX17: view

Gene Ontology (GO) - Biological Process for STX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IMP 21545355
GO:0097111 endoplasmic reticulum-Golgi intermediate compartment organization IMP 21545355
genes like me logo Genes that share ontologies with STX17: view

No data available for SIGNOR curated interactions for STX17 Gene

Drugs & Compounds for STX17 Gene

No Compound Related Data Available

Transcripts for STX17 Gene

Unigene Clusters for STX17 Gene

Syntaxin 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STX17 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: -
SP7:

Relevant External Links for STX17 Gene

GeneLoc Exon Structure for
STX17
ECgene alternative splicing isoforms for
STX17

Expression for STX17 Gene

mRNA expression in normal human tissues for STX17 Gene

Protein differential expression in normal tissues from HIPED for STX17 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.7), Bone (9.3), and Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX17 Gene



SOURCE GeneReport for Unigene cluster for STX17 Gene Hs.704031

genes like me logo Genes that share expression patterns with STX17: view

Protein tissue co-expression partners for STX17 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STX17 Gene

Orthologs for STX17 Gene

This gene was present in the common ancestor of animals.

Orthologs for STX17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STX17 35
  • 94.48 (n)
  • 94.04 (a)
STX17 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STX17 35
  • 95.25 (n)
  • 95.7 (a)
STX17 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stx17 35
  • 88.7 (n)
  • 92.69 (a)
Stx17 16
Stx17 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STX17 35
  • 99.56 (n)
  • 100 (a)
STX17 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stx17 35
  • 87.93 (n)
  • 91.03 (a)
oppossum
(Monodelphis domestica)
Mammalia STX17 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX17 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves STX17 35
  • 79.26 (n)
  • 75.92 (a)
STX17 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX17 36
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii stx17 35
  • 63.1 (n)
  • 59.78 (a)
stx17 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005684 35
  • 42.07 (n)
  • 30.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syx17 35
  • 43.9 (n)
  • 34.16 (a)
Syx17 36
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToOne
Species with no ortholog for STX17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STX17 Gene

ENSEMBL:
Gene Tree for STX17 (if available)
TreeFam:
Gene Tree for STX17 (if available)

Paralogs for STX17 Gene

(1) SIMAP similar genes for STX17 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with STX17: view

No data available for Paralogs for STX17 Gene

Variants for STX17 Gene

Sequence variations from dbSNP and Humsavar for STX17 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs9556 -- 99,969,955(-) CATGC(A/G)GTTGG nc-transcript-variant, utr-variant-3-prime
rs1133711 -- 99,972,221(+) GATTT(C/T)TTAAT nc-transcript-variant, utr-variant-3-prime
rs1133713 -- 99,972,231(+) TGTTC(A/C)CTAGT nc-transcript-variant, utr-variant-3-prime
rs1133718 -- 99,972,950(+) AATCA(C/G)AGGCC nc-transcript-variant, utr-variant-3-prime
rs1830454 -- 99,955,851(+) CAGTT(A/G)CAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STX17 Gene

Variant ID Type Subtype PubMed ID
nsv831668 CNV Gain+Loss 17160897
nsv893623 CNV Gain 21882294
nsv825011 CNV Loss 20364138

Variation tolerance for STX17 Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STX17 Gene

HapMap Linkage Disequilibrium report
STX17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX17 Gene

Disorders for STX17 Gene

Relevant External Links for STX17

Genetic Association Database (GAD)
STX17
Human Genome Epidemiology (HuGE) Navigator
STX17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STX17

No disorders were found for STX17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX17 Gene

Publications for STX17 Gene

  1. Polymorphisms in the syntaxin 17 gene are not associated with human cutaneous malignant melanoma. (PMID: 19209086) Zhao Z.Z. … Montgomery G.W. (Melanoma Res. 2009) 3 23 48 67
  2. Three novel proteins of the syntaxin/SNAP-25 family. (PMID: 9852078) Steegmaier M. … Scheller R.H. (J. Biol. Chem. 1998) 2 3 23
  3. Syntaxin 17 is abundant in steroidogenic cells and implicated in smooth endoplasmic reticulum membrane dynamics. (PMID: 10930465) Steegmaier M. … Scheller R.H. (Mol. Biol. Cell 2000) 3 23
  4. A role for the ancient SNARE syntaxin 17 in regulating mitochondrial division. (PMID: 25619926) Arasaki K. … Tagaya M. (Dev. Cell 2015) 3
  5. The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17. (PMID: 24554770) Jiang P. … Mizushima N. (Mol. Biol. Cell 2014) 3

Products for STX17 Gene

Sources for STX17 Gene

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