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STX17 Gene

protein-coding   GIFtS: 50
GCID: GC09P102668

Syntaxin 17

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Syntaxin 171 2
syntaxin-172

External Ids:    HGNC: 114321   Entrez Gene: 550142   Ensembl: ENSG000001368747   OMIM: 6042045   UniProtKB: P569623   

Export aliases for STX17 gene to outside databases

Previous GC identifers: GC00U990459 GC09P098048 GC09P099748 GC09P101708 GC09P072267


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STX17 Gene:
STX17 (syntaxin 17) is a protein-coding gene. Diseases associated with STX17 include childhood type dermatomyositis, and dermatomyositis. GO annotations related to this gene include protein phosphatase binding and SNARE binding.

UniProtKB/Swiss-Prot: STX17_HUMAN, P56962
Function: SNAREs, Soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins
for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex,
an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the
autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome
membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the
endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the
endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the STX17 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pax-6   Nkx3-1 v1   LUN-1   HNF-1A   C/EBPalpha   Nkx3-1 v2   HNF-1   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTX17 promoter sequence
   Search Chromatin IP Primers for STX17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STX17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.1   Ensembl cytogenetic band:  9q31.1   HGNC cytogenetic band: 9q31.1

STX17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STX17 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P102668:  view genomic region     (about GC identifiers)

Start:
102,668,915 bp from pter      End:
102,736,818 bp from pter
Size:
67,904 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: STX17_HUMAN, P56962 (See protein sequence)
Recommended Name: Syntaxin-17  
Size: 302 amino acids; 33403 Da
Subunit: Forms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with
lysosome. May interact with VAMP7. May interact with VTI1B. Probably interacts with BET1, SCFD1 and SEC22B (By
similarity). Interacts with PTPN2 and ABL1; involved in STX17 phosphorylation. Interacts with COPB1 (By
similarity). Interacts with TMED9 and TMED10; the interaction is direct
Secondary accessions: Q4VXC2

Explore the universe of human proteins at neXtProt for STX17: NX_P56962

Explore proteomics data for STX17 at MOPED

Post-translational modifications: 

  • Phosphorylated at Tyr-157 probably by ABL1. Dephosphorylation by PTPN2; regulates exit from the endoplasmic
    reticulum (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STX17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060389.2  
    ENSEMBL proteins: 
     ENSP00000259400   ENSP00000434323   ENSP00000433694   ENSP00000433701   ENSP00000436666  
     ENSP00000435981   ENSP00000433484   ENSP00000434547  

    STX17 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for STX17
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    Novus Biologicals STX17 Protein
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for STX17
    Cloud-Clone Corp. Proteins for STX17

    STX17 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for STX17

    STX17 Assay Products:

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    Cloud-Clone Corp. CLIAs for STX17


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000727 T_SNARE_dom
     IPR010989 t-SNARE
     IPR028676 STX17
     IPR006012 Syntaxin/epimorphin_CS

    Graphical View of Domain Structure for InterPro Entry P56962

    ProtoNet protein and cluster: P56962

    UniProtKB/Swiss-Prot: STX17_HUMAN, P56962
    Similarity: Belongs to the syntaxin family
    Similarity: Contains 1 t-SNARE coiled-coil homology domain


    STX17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STX17_HUMAN, P56962
    Function: SNAREs, Soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins
    for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex,
    an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the
    autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome
    membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the
    endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the
    endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding IDA--
    GO:0005484SNAP receptor activity IMP--
    GO:0005515protein binding ----
    GO:0019901protein kinase binding IEA--
    GO:0019903protein phosphatase binding IPI--
         
    STX17 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for STX17:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella-containin 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STX17
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STX17
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STX17

    miRNA
    Products:
        
    miRTarBase miRNAs that target STX17:
    hsa-mir-30b-5p (MIRT046119)

    Block miRNA regulation of human, mouse, rat STX17 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STX17 (see all 84):
    hsa-miR-15a hsa-miR-30d hsa-miR-374a hsa-miR-1304 hsa-miR-30a hsa-miR-629* hsa-miR-149 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmidSTX17 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STX17
    Predesigned siRNA for gene silencing in human, mouse, rat STX17

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for STX17
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    GenScript: all cDNA clones in your preferred vector: STX17 (NM_017919)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX17

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    Browse ESI BIO Cell Lines and PureStem Progenitors for STX17 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX17


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STX17_HUMAN, P56962: Endoplasmic reticulum membrane; Multi-pass membrane protein. Smooth endoplasmic reticulum
    membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum-Golgi intermediate compartment
    membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein.
    Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein (By similarity). Cytoplasm,
    cytosol (By similarity). Note=Has an hairpin-like insertion into membranes. Localized into endoplasmic reticulum
    membranes, it also localizes to the completed autophagosome membrane upon cell starvation. May also localize to
    the mitochondria according to PubMed:23217709. A significant amount is also present in the cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    vacuole5
    cytosol3
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000421autophagic vacuole membrane IDA--
    GO:0005739NOT mitochondrion IDA10930465
    GO:0005765NOT lysosomal membrane IDA10930465
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IDA--

    STX17 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STX17 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 PharmGKB Pathway for STX17
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    1 Kegg Pathway  (Kegg details for STX17):
        SNARE interactions in vesicular transport


    STX17 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STX17
    Interactions:

        Search GeneGlobe Interaction Network for STX17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STX17 (P569623 ENSP000002594004) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNAP29O957213, ENSP000002157304I2D: score=2 STRING: ENSP00000215730
    NAPBQ9H1153, ENSP000003662254I2D: score=1 STRING: ENSP00000366225
    STX5Q131903, ENSP000002941794I2D: score=1 STRING: ENSP00000294179
    STX8ENSP000003052554STRING: ENSP00000305255
    STX10ENSP000002427704STRING: ENSP00000242770
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000046autophagic vacuole fusion IMP--
    GO:0006886intracellular protein transport IBA--
    GO:0006887exocytosis IBA--
    GO:0006888ER to Golgi vesicle-mediated transport IMP--
    GO:0007030Golgi organization IMP--

    STX17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STX17



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STX17 gene: 
    NM_017919.2  

    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259400(uc004bak.3 uc004bal.4 uc010msx.3 uc011lvd.2)
    ENST00000529340 ENST00000533696 ENST00000531035 ENST00000525342 ENST00000524405
    ENST00000525640 ENST00000534052 ENST00000526607 ENST00000525579 ENST00000525847
    ENST00000529385
    miRNA
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    Block miRNA regulation of human, mouse, rat STX17 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STX17 (see all 84):
    hsa-miR-15a hsa-miR-30d hsa-miR-374a hsa-miR-1304 hsa-miR-30a hsa-miR-629* hsa-miR-149 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmidSTX17 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STX17
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    GenScript: all cDNA clones in your preferred vector: STX17 (NM_017919)
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    Primer
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    OriGene qPCR primer pairs and template standards for STX17
    OriGene qSTAR qPCR primer pairs in human, mouse for STX17
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STX17
      QuantiTect SYBR Green Assays in human, mouse, rat STX17
      QuantiFast Probe-based Assays in human, mouse, rat STX17

    Selected AceView cDNA sequences (see all 203):

    AA621235 BQ188170 AA829234 CB854797 BQ024651 BM744391 AI686264 BP372636 
    AL698118 BQ025791 BQ721959 AA127308 BM919844 AI858607 CA427478 BQ185335 
    AA665575 F09690 AA766035 N55187 BC070269 N34126 BG258148 BU726656 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STX17 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:              -           -     -                 -                           
    SP2:              -           -     -     -           -                           
    SP3:                          -     -                 -                           
    SP4:              -           -                                                   
    SP5:              -           -     -                                             


    ECgene alternative splicing isoforms for STX17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STX17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    STX17 Expression
    About this image

    STX17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STX17 Protein Expression
        Custom PCR Arrays for STX17
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STX17 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stx171 , 5 syntaxin 171, 5 88.7(n)1
    92.69(a)1
      4 (26.07 cM)5
    677271  NM_026343.21  NP_080619.21 
     481249155 
    chicken
    (Gallus gallus)
    Aves STX171 syntaxin 17 79.26(n)
    75.92(a)
      420995  NM_001031009.1  NP_001026180.1 
    lizard
    (Anolis carolinensis)
    Reptilia STX176
    syntaxin 17
    72(a)
    1 ↔ 1
    GL344245.1(7304-31405)
    zebrafish
    (Danio rerio)
    Actinopterygii stx171 syntaxin 17 63.1(n)
    59.78(a)
      492808  NM_001007449.1  NP_001007450.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syx171 Syntaxin 17 43.9(n)
    34.16(a)
      38541  NM_001274485.1  NP_001261414.1 


    ENSEMBL Gene Tree for STX17 (if available)
    TreeFam Gene Tree for STX17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STX17 gene
    1 SIMAP similar gene for STX17 using alignment to 7 protein entries:     STX17_HUMAN (see all proteins):
    DKFZp762D1813

    STX17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STX17 (see all 1024)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456496971,2
    --102671006(+) GACCCA/GTAGTT 1 -- int10--------
    rs1807867891,2
    --102671256(+) TTGTCC/TCTTAT 1 -- int10--------
    rs1409445591,2
    --102671378(+) ATGTTA/CCTGTG 1 -- int10--------
    rs1843390411,2
    --102671464(+) TTTTCC/TAAAGT 1 -- int10--------
    rs1423860671,2
    C--102671471(+) AAGTGA/GCTTAG 1 -- int10--------
    rs1512833491,2
    --102671569(+) GAGGGA/CAAGAG 1 -- int10--------
    rs1404887261,2
    --102671797(+) AGGCAA/GTGTGA 1 -- int10--------
    rs1886463801,2
    C--102671811(+) ATTGGG/TAAATG 1 -- int10--------
    rs610420771,2
    C,F--102672091(+) ATGCTT/CGAGGT 1 -- int12Minor allele frequency- C:0.09WA 120
    rs109889191,2
    C,F,A,H--102672253(+) ctcacG/Acttgt 1 -- int15Minor allele frequency- A:0.40NA WA CSA 10

    HapMap Linkage Disequilibrium report for STX17 (102668915 - 102736818 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for STX17:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv825011CNV Loss20364138
    nsv893623CNV Gain21882294
    nsv831668CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STX17
    DNA2.0 Custom Variant and Variant Library Synthesis for STX17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604204    OMIM disorders: --

    9 diseases for STX17:    About MalaCards
    childhood type dermatomyositis    dermatomyositis    cutaneous malignant melanoma    alopecia areata
    alopecia    vitiligo    melanoma    malaria
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for STX17:
    Vitiligo

    STX17 for disorders           About GeneDecksing

    Genetic Association Database (GAD): STX17
    Human Genome Epidemiology (HuGE) Navigator: STX17 (2 documents)

    Export disorders for STX17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STX17 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with STX17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms in the syntaxin 17 gene are not associated with human cutaneous malignant melanoma. (PubMed id 19209086)1, 4, 9 Zhao Z.Z....Montgomery G.W. (Melanoma Res. 2009)
    2. Three novel proteins of the syntaxin/SNAP-25 family. (PubMed id 9852078)1, 3, 9 Steegmaier M....Scheller R.H. (J. Biol. Chem. 1998)
    3. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. (PubMed id 23217709)1, 2 Itakura E.... Mizushima N. (Cell 2012)
    4. Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi. (PubMed id 21545355)1, 2 Muppirala M.... Swarup G. (Biol. Cell 2011)
    5. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. (PubMed id 20596022)1, 4 Petukhova L....Christiano A.M. (Nature 2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Syntaxin 17 is abundant in steroidogenic cells and implicated in smooth endoplasmic reticulum membrane dynamics. (PubMed id 10930465)1, 9 Steegmaier M....Scheller R.H. (Mol. Biol. Cell 2000)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Tyrosine phosphorylation of a SNARE protein, Syntaxin 17: Implications for membrane trafficking in the early secretory pathway. (PubMed id 23006999)2 Muppirala M.... Swarup G. (Biochim. Biophys. Acta 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55014 HGNC: 11432 AceView: STX17 Ensembl:ENSG00000136874 euGenes: HUgn55014
    ECgene: STX17 Kegg: 55014 H-InvDB: STX17

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STX17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STX17 gene:
    Search GeneIP for patents involving STX17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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