STX17 Gene
protein-coding GIFtS: 51
GCID: GC09P102668
|
|
syntaxin 17
| |
Aliases
for STX17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Syntaxin 171 2 | | FLJ206511 | | Syntaxin-171 |
Export aliases for STX17 gene to outside databasesPrevious GC identifers: GC00U990459 GC09P098048 GC09P099748 GC09P101708 GC09P072267 |
Summaries
for STX17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: STX17_HUMAN, P56962Function: Implicated in vesicle trafficking to lysosomes. Could be involved in processes related to cell division (Bysimilarity)
|
Genomic Views
for STX17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STX17 gene promoter:
Nkx3-1 Nkx3-1 v4 Pax-6 Nkx3-1 v1 LUN-1 HNF-1A C/EBPalpha Nkx3-1 v2 HNF-1 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for STX17
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX17 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q31.1 Ensembl cytogenetic band: 9q31.1 HGNC cytogenetic band: 9q31.1STX17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P102668: view genomic region
(about GC identifiers)
Start:
|
102,668,915 bp from pter |
End:
|
102,736,818 bp from pter |
Size:
|
67,904 bases |
Orientation:
|
plus strand |
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Proteins
for STX17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STX17_HUMAN, P56962 (See
protein sequence)Recommended Name: Syntaxin-17 Size: 302 amino acids; 33403 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum-Golgiintermediate compartment membrane; Single-pass type IV membrane protein
Secondary accessions: Q4VXC2Explore the universe of human proteins at neXtProt for STX17: NX_P56962
Post-translational modifications:
Dephosphorylated at Tyr-157 by PTPN2 isoform TC48 (in vitro)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P56962
STX17 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060389.2
ENSEMBL proteins: ENSP00000259400 ENSP00000434323 ENSP00000433694 ENSP00000433701 ENSP00000436666 ENSP00000435981 ENSP00000433484 ENSP00000434547
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
STX17 for ontologies About GeneDecksing
STX17 Antibody Products:
Assay Products for STX17: |
Protein
Domains /
Families
for STX17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STX17 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P56962ProtoNet protein and cluster: P56962 UniProtKB/Swiss-Prot: STX17_HUMAN, P56962Similarity: Belongs to the syntaxin familySimilarity: Contains 1 t-SNARE coiled-coil homology domain |
Function
for STX17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STX17_HUMAN, P56962Function: Implicated in vesicle trafficking to lysosomes. Could be involved in processes related to cell division (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX17 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX17 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: STX17 (NM_017919) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STX17 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX17 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX17 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000149 | SNARE binding |
IBA | -- | | GO:0005484 | SNAP receptor activity |
IBA | -- |
STX17 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for STX17:
|
Pathways & Interactions
for STX17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  PharmGKB Pathway for STX17
1 
Kegg Pathway (Kegg details for STX17):
STX17 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STX17
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/9 Interacting proteins for STX17 (P569623 ENSP000002594004) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006886 | intracellular protein transport |
IBA | -- | | GO:0006887 | exocytosis |
IBA | -- | | GO:0016192 | vesicle-mediated transport |
-- | -- |
STX17 for ontologies About GeneDecksing
|
Drugs & Compounds
for STX17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STX17
Search CenterWatch for drugs/clinical trials and news about STX17
|
Transcripts
for STX17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STX17 gene: NM_017919.2 Unigene Cluster for STX17: Syntaxin 17 Hs.704031 [show with all ESTs]Unigene Representative Sequence: NM_01791912 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000259400(uc004bak.3 uc004bal.4 uc010msx.3 uc011lvd.2)
ENST00000529340 ENST00000533696 ENST00000531035 ENST00000525342 ENST00000524405
ENST00000525640 ENST00000534052 ENST00000526607 ENST00000525579 ENST00000525847
ENST00000529385
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX17 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX17 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STX17 (NM_017919) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STX17 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX17 |
Additional cDNA sequence: AK000658.1 AK095262.1 AK124662.1 AK295949.1 AK311412.1 AL833620.1 AL834371.1 BC039048.1 BC070269.1 BC101564.1 BC101566.1 BC111009.1 BC143430.1 11 DOTS entries: DT.415865 DT.100751159 DT.310276 DT.97767798 DT.100792285 DT.121190048 DT.91701696 DT.95123999 DT.102831003 DT.100751158 DT.97838778 24/203 AceView cDNA sequences (see all 203): F12048 T81598 BM710058 BQ027251 CR608387 CA427478 N55187 BQ025791 BE018348 BQ185335 BM978739 AA829234 AA343122 AI858607 BQ024651 BP372636 AW613068 AA621235 AA766035 BU726656 BQ188170 BM919844 N34126 AI686264
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for STX17 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c |
|---|
|
| SP1: | | | | | - | | | | - | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | - | | | | - | | - | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | |
| SP4: | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for STX17
|
Expression
for STX17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STX17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See STX17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STX17
SOURCE GeneReport for Unigene cluster: Hs.704031
SABiosciences Custom PCR Arrays for STX17
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STX17
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STX17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX17 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX17 |
Orthologs
for STX17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for STX17 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for STX17 (if available)
TreeFam Gene Tree for STX17 (if available) |
Paralogs
for STX17 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for STX17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STX17 (102668915 - 102736818 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for STX17
1 CNV: 4649 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STX17 |
|
Disorders
/ Diseases
for STX17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STX17 for disorders About GeneDecksing
OMIM gene information: 604204
OMIM disorders: --
7  diseases for STX17: About MalaCardschildhood type dermatomyositis alopecia areata cutaneous malignant melanoma alopecia
dermatomyositis vitiligo melanoma
1 disease from the University of Copenhagen DISEASES database for STX17:Vitiligo Human Genome Epidemiology (HuGE) Navigator: STX17 (2 documents)
Export disorders for STX17 gene to outside databases
|
Publications
for STX17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STX17 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with STX17) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Three novel proteins of the syntaxin/SNAP-25 family. (PubMed id 9852078)1, 3, 9 Steegmaier M....Scheller R.H. (1998)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Syntaxin 17 is abundant in steroidogenic cells and implicated in smooth endoplasmic reticulum membrane dynamics. (PubMed id 10930465)1, 9 Steegmaier M....Scheller R.H. (2000)
- Polymorphisms in the syntaxin 17 gene are not associated with human cutaneous malignant melanoma. (PubMed id 19209086)1, 9 Zhao Z.Z....Montgomery G.W. (2009)
- The hairpin-type tail-anchored SNARE syntaxin 17 targe ts to autophagosomes for fusion with endosomes/lysosomes. (PubMed id 23217709)1 Itakura E....Mizushima N. (2012)
- Tyrosine phosphorylation of a SNARE protein, Syntaxin 17: Implications for membrane trafficking in the early secretory pathway. (PubMed id 23006999)2 Muppirala M.... Swarup G. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Syntaxin 17 cycles between the ER and ERGIC and is re quired to maintain the architecture of ERGIC and Golgi. (PubMed id 21545355)1 Muppirala M....Swarup G. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for STX17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STX17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STX17 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STX17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STX17 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STX17 gene:
Search GeneIP for patents involving STX17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STX17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for STX17 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STX17 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STX17 | | | OriGene Protein Over-expression Lysate for STX17 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STX17 | | OriGene 3'-UTR Clone for STX17 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX17 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX17 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for STX17 | | OriGene Custom Protein Services for STX17 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STX17 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STX17 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX17 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX17 |
| |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX17 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX17 |
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