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Aliases for STX16-NPEPL1 Gene

Subcategory (RNA class) for STX16-NPEPL1 Gene


Quality Score for this RNA gene is


Aliases for STX16-NPEPL1 Gene

  • STX16-NPEPL1 Readthrough (NMD Candidate) 2 3 5

External Ids for STX16-NPEPL1 Gene

Previous GeneCards Identifiers for STX16-NPEPL1 Gene

  • GC20U900674
  • GC20P057228
  • GC20P057229

Summaries for STX16-NPEPL1 Gene

Entrez Gene Summary for STX16-NPEPL1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring syntaxin 16 (STX16) and aminopeptidase-like 1 (NPEPL1) genes on chromosome 20. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Mar 2011]

GeneCards Summary for STX16-NPEPL1 Gene

STX16-NPEPL1 (STX16-NPEPL1 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. GO annotations related to this gene include SNAP receptor activity. An important paralog of this gene is STX16.

Additional gene information for STX16-NPEPL1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX16-NPEPL1 Gene

Genomics for STX16-NPEPL1 Gene

Regulatory Elements for STX16-NPEPL1 Gene

Enhancers for STX16-NPEPL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H058677 0.2 ENCODE 11.4 +26.8 26767 0.2 STX16 STX16-NPEPL1 PIR50186
GH20H058649 1.5 ENCODE dbSUPER 0.7 +0.8 817 5.8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC LOC101927932 PPP4R1L NELFCD ENSG00000254419 STX16 NPEPL1 ENSG00000270279 PIEZO1P2 ANKRD60 ENSG00000227282
GH20H058659 1 Ensembl ENCODE dbSUPER 0.4 +8.6 8648 0.6 PKNOX1 RFX1 BMI1 SPI1 NPEPL1 STX16 STX16-NPEPL1 PIR50186
GH20H058655 1 Ensembl ENCODE dbSUPER 0.4 +5.5 5519 2.7 PRDM6 ID3 PRDM1 NR2F2 NPEPL1 LINC01711 STX16 STX16-NPEPL1 PIR50186
GH20H058660 1 FANTOM5 ENCODE dbSUPER 0.4 +10.4 10415 1.5 KLF9 ZBTB33 NPEPL1 LINC01711 STX16 RAB22A STX16-NPEPL1 PIR50186
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STX16-NPEPL1 on UCSC Golden Path with GeneCards custom track

Promoters for STX16-NPEPL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139422 347 4001 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC

Genomic Locations for STX16-NPEPL1 Gene

Genomic Locations for STX16-NPEPL1 Gene
64,592 bases
Plus strand

Genomic View for STX16-NPEPL1 Gene

Genes around STX16-NPEPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX16-NPEPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX16-NPEPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX16-NPEPL1 Gene

Proteins for STX16-NPEPL1 Gene

  • Protein details for STX16-NPEPL1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    STX16-NPEPL1 readthrough (NMD candidate)
    Protein Accession:

    Protein attributes for STX16-NPEPL1 Gene

    382 amino acids
    Molecular mass:
    43229 Da
    Quaternary structure:
    No Data Available

neXtProt entry for STX16-NPEPL1 Gene

Post-translational modifications for STX16-NPEPL1 Gene

No Post-translational modifications

Other Protein References for STX16-NPEPL1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for STX16-NPEPL1 Gene

Domains & Families for STX16-NPEPL1 Gene

Protein Domains for STX16-NPEPL1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STX16-NPEPL1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for STX16-NPEPL1 Gene

Function for STX16-NPEPL1 Gene

Gene Ontology (GO) - Molecular Function for STX16-NPEPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IBA --
genes like me logo Genes that share ontologies with STX16-NPEPL1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STX16-NPEPL1 Gene

Localization for STX16-NPEPL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STX16-NPEPL1 gene
Compartment Confidence
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for STX16-NPEPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
GO:0031201 SNARE complex IBA --
genes like me logo Genes that share ontologies with STX16-NPEPL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for STX16-NPEPL1 Gene

Pathways & Interactions for STX16-NPEPL1 Gene

SuperPathways for STX16-NPEPL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STX16-NPEPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006906 vesicle fusion IBA --
GO:0016192 vesicle-mediated transport IEA --
GO:0048278 vesicle docking IBA --
genes like me logo Genes that share ontologies with STX16-NPEPL1: view

No data available for Pathways by source and SIGNOR curated interactions for STX16-NPEPL1 Gene

Drugs & Compounds for STX16-NPEPL1 Gene

No Compound Related Data Available

Transcripts for STX16-NPEPL1 Gene

mRNA/cDNA for STX16-NPEPL1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX16-NPEPL1 Gene

No ASD Table

Relevant External Links for STX16-NPEPL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STX16-NPEPL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STX16-NPEPL1 Gene

mRNA differential expression in normal tissues according to GTEx for STX16-NPEPL1 Gene

This gene is overexpressed in Brain - Cerebellum (x5.7) and Brain - Cerebellar Hemisphere (x4.2).
genes like me logo Genes that share expression patterns with STX16-NPEPL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for STX16-NPEPL1 Gene

Orthologs for STX16-NPEPL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STX16-NPEPL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STX16-NPEPL1 34
  • 98 (a)
(Mus musculus)
Mammalia Stx16 34
  • 87 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
(Gallus gallus)
Aves STX16 34
  • 79 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 77 (a)
(Danio rerio)
Actinopterygii stx16 34
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syx16 34
  • 32 (a)
(Caenorhabditis elegans)
Secernentea syx-16 34
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TLG2 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
Species where no ortholog for STX16-NPEPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for STX16-NPEPL1 Gene

Gene Tree for STX16-NPEPL1 (if available)
Gene Tree for STX16-NPEPL1 (if available)

Paralogs for STX16-NPEPL1 Gene

Paralogs for STX16-NPEPL1 Gene

(1) SIMAP similar genes for STX16-NPEPL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STX16-NPEPL1: view

Variants for STX16-NPEPL1 Gene

Sequence variations from dbSNP and Humsavar for STX16-NPEPL1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs111631847 Likely benign 58,678,371(+) GGAGG(A/G)GCTGG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs114786310 Likely benign 58,670,524(+) GAATC(A/G)AGAGG nc-transcript-variant, reference, missense
rs115046538 Likely benign 58,667,562(+) CAAAA(C/G/T)GGCCA nc-transcript-variant, reference, missense
rs138647604 Likely benign 58,669,353(+) TCCGA(G/T)CAGGA intron-variant, nc-transcript-variant, reference, missense
rs138678203 Likely benign 58,678,190(+) CCGGA(C/T)TTCTG intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for STX16-NPEPL1 Gene

Variant ID Type Subtype PubMed ID
esv1002410 CNV deletion 20482838
esv1198718 CNV insertion 17803354
esv2558295 CNV insertion 19546169
esv2665738 CNV deletion 23128226
esv3646226 CNV loss 21293372
nsv1063462 CNV gain 25217958
nsv1118920 CNV deletion 24896259
nsv1125729 CNV tandem duplication 24896259
nsv1129663 CNV tandem duplication 24896259
nsv513552 CNV insertion 21212237
nsv955141 CNV deletion 24416366
nsv828762 CNV loss 20364138
nsv828761 CNV loss 20364138

Relevant External Links for STX16-NPEPL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for STX16-NPEPL1 Gene

Disorders for STX16-NPEPL1 Gene

Relevant External Links for STX16-NPEPL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STX16-NPEPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX16-NPEPL1 Gene

Publications for STX16-NPEPL1 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 60

Products for STX16-NPEPL1 Gene

Sources for STX16-NPEPL1 Gene

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