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STX16 Gene

protein-coding   GIFtS: 62
GCID: GC20P057226

Syntaxin 16

  See STX16-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Syntaxin 161 2
SYN162 5
syntaxin-162
Syn163

External Ids:    HGNC: 114311   Entrez Gene: 86752   Ensembl: ENSG000001242227   OMIM: 6036665   UniProtKB: O146623   

Export aliases for STX16 gene to outside databases

Previous GC identifers: GC20P056955 GC20P057864 GC20P057912 GC20P056659 GC20P054010


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STX16 Gene:
This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These
proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting
specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is
located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found
for this gene. Read-through transcription also exists between this gene and the neighboring downstream
aminopeptidase-like 1 (NPEPL1) gene. (provided by RefSeq, Mar 2011)

GeneCards Summary for STX16 Gene:
STX16 (syntaxin 16) is a protein-coding gene. Diseases associated with STX16 include pseudohypoparathyroidism type 1b, and pseudohypoparathyroidism. GO annotations related to this gene include SNAP receptor activity. An important paralog of this gene is STX16-NPEPL1.

UniProtKB/Swiss-Prot: STX16_HUMAN, O14662
Function: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network

Gene Wiki entry for STX16 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the STX16 gene promoter:
         HFH-3   C/EBPbeta   SREBP-1c   Pax-6   Nkx2-5   HNF-3beta   SREBP-1b   C/EBPalpha   FOXI1   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTX16 promoter sequence
   Search Chromatin IP Primers for STX16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STX16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.32   Ensembl cytogenetic band:  20q13.32   HGNC cytogenetic band: 20q13.32

STX16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STX16 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P057226:  view genomic region     (about GC identifiers)

Start:
57,226,309 bp from pter      End:
57,254,582 bp from pter
Size:
28,274 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for STX16

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STX16_HUMAN, O14662 (See protein sequence)
Recommended Name: Syntaxin-16  
Size: 325 amino acids; 37031 Da
Subunit: Interacts with GCC2
Sequence caution: Sequence=AAB69282.1; Type=Frameshift; Positions=142, 163, 165; Sequence=AAB69283.1;
Type=Frameshift; Positions=142, 163, 165; Sequence=AAC05647.1; Type=Frameshift; Positions=142, 163, 165;
Secondary accessions: A6NK32 A6NN69 A8MPP0 B7ZBN1 B7ZBN2 B7ZBN3 E1P5M0 E1P607 O14661 O14663
O60517 Q5W084 Q5W086 Q5W087 Q5XKI6 Q6GMS8 Q9H0Z0 Q9H1T7 Q9H1T8 Q9UIX5
Alternative splicing: 6 isoforms:  O14662-1   O14662-2   O14662-3   O14662-4   O14662-5   O14662-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STX16: NX_O14662

Explore proteomics data for STX16 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STX16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001001433.1  NP_001128244.1  NP_001128245.1  NP_001191797.1  NP_003754.2  

    ENSEMBL proteins: 
     ENSP00000388348   ENSP00000348229   ENSP00000312086   ENSP00000416852   ENSP00000435118  
     ENSP00000352634   ENSP00000360183   ENSP00000437209   ENSP00000432823   ENSP00000360173  
     ENSP00000434369   ENSP00000350723   ENSP00000432414   ENSP00000436667   ENSP00000401801  
     ENSP00000355408   ENSP00000354445  

    STX16 Human Recombinant Protein Products:

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    Novus Biologicals STX16 Proteins
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for STX16

     
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    STX16 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Cloud-Clone Corp. ELISAs for STX16
    Cloud-Clone Corp. CLIAs for STX16
    Search eBioscience for ELISAs for STX16 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR000727 T_SNARE_dom
     IPR010989 t-SNARE
     IPR006011 Syntaxin_N
     IPR028673 STX16
     IPR006012 Syntaxin/epimorphin_CS

    Graphical View of Domain Structure for InterPro Entry O14662

    ProtoNet protein and cluster: O14662

    1 Blocks protein domain: IPB006011 Syntaxin

    UniProtKB/Swiss-Prot: STX16_HUMAN, O14662
    Similarity: Belongs to the syntaxin family
    Similarity: Contains 1 t-SNARE coiled-coil homology domain


    Find genes that share domains with STX16           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STX16_HUMAN, O14662
    Function: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005484SNAP receptor activity IDA15215310
    GO:0005515protein binding IPI18195106
         
    Find genes that share ontologies with STX16           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for STX16:
     Decreased cell number  Decreased viability with pacli 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Stx16):
     normal 

    Find genes that share phenotypes with STX16           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Stx16tm1Hju for STX16

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STX16
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STX16
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STX16

    miRNA
    Products:
        
    miRTarBase miRNAs that target STX16:
    hsa-mir-193b-3p (MIRT041539), hsa-mir-93-5p (MIRT048767), hsa-mir-331-3p (MIRT043405), hsa-mir-30a-5p (MIRT028613), hsa-mir-24-3p (MIRT030553), hsa-mir-324-3p (MIRT042882), hsa-mir-455-3p (MIRT037804)

    Block miRNA regulation of human, mouse, rat STX16 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STX16 (see all 96):
    hsa-miR-582-3p hsa-miR-520e hsa-miR-520f hsa-miR-193a-3p hsa-miR-3152-3p hsa-miR-300 hsa-miR-200a hsa-miR-134
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STX16

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for STX16
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    GenScript: all cDNA clones in your preferred vector (see all 5): STX16 (NM_003763)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STX16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX16

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    Browse ESI BIO Cell Lines and PureStem Progenitors for STX16 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX16


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STX16_HUMAN, O14662: Golgi apparatus membrane; Single-pass type IV membrane protein
    STX16_HUMAN, O14662: Isoform C: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus4
    cytosol3
    mitochondrion3
    endosome2
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm TAS9587053
    GO:0005794Golgi apparatus TAS9587053
    GO:0016020membrane ----

    Find genes that share ontologies with STX16           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STX16 About    
    See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    2Transmission across Chemical Synapses
    Neuronal System0.68
    3Clathrin dependent protein traffic
    Transport Clathrin coated vesicle cycle0.66
    4Disease
    Disease


    Find genes that share SuperPaths with STX16           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for STX16
        Transport Clathrin-coated vesicle cycle

    1 PharmGKB Pathway for STX16
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    1 Kegg Pathway  (Kegg details for STX16):
        SNARE interactions in vesicular transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STX16
    Interactions:

        GeneGlobe Interaction Network for STX16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STX16 (O146622, 3 ENSP000003601834) via UniProtKB, MINT, STRING, and/or I2D (see all 203)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN12Q052092, 3MINT-61774 I2D: score=3 
    VAMP3Q158363, ENSP000000546664I2D: score=3 STRING: ENSP00000054666
    STX6O437523, ENSP000002583014I2D: score=2 STRING: ENSP00000258301
    VTI1AQ96AJ93, ENSP000003767924I2D: score=1 STRING: ENSP00000376792
    VPS45Q9NRW73, ENSP000003581264I2D: score=2 STRING: ENSP00000358126
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006891intra-Golgi vesicle-mediated transport TAS9464276
    GO:0016192vesicle-mediated transport ----
    GO:0042147retrograde transport, endosome to Golgi IDA15215310

    Find genes that share ontologies with STX16           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STX16



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STX16 gene (6 alternative transcripts): 
    NM_001001433.2  NM_001134772.2  NM_001134773.2  NM_001204868.1  NM_003763.5  NM_001001434.1  

    Unigene Cluster for STX16:

    Syntaxin 16
    Hs.307913  [show with all ESTs]
    Unigene Representative Sequence: NM_001001433
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000458280 ENST00000355957(uc002xzk.3 uc002xzl.3) ENST00000312283
    ENST00000412911 ENST00000460655 ENST00000359617 ENST00000371141(uc021wfi.1 uc002xzi.3 uc010zzq.2 uc002xzm.3)
    ENST00000476384 ENST00000483434 ENST00000496117 ENST00000490700 ENST00000371132
    ENST00000496003 ENST00000467096 ENST00000358029 ENST00000464640 ENST00000493301
    ENST00000468590
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate STX16 (see all 96):
    hsa-miR-582-3p hsa-miR-520e hsa-miR-520f hsa-miR-193a-3p hsa-miR-3152-3p hsa-miR-300 hsa-miR-200a hsa-miR-134
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    OriGene clones in human, mouse for STX16 (see all 24)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): STX16 (NM_003763)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX16
    Primer
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    OriGene qPCR primer pairs and template standards for STX16
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      QuantiTect SYBR Green Assays in human, mouse, rat STX16
      QuantiFast Probe-based Assays in human, mouse, rat STX16

    Additional mRNA sequence: 

    AF008935.1 AF008936.1 AF038897.1 AF305817.1 AK026970.1 AK026974.1 AK296282.1 AK304867.1 
    AK316547.1 AL359056.1 BC019042.2 BC073876.1 DQ268529.1 DQ272217.1 NR_037941.1 NR_037942.1 
    NR_037943.1 

    20 DOTS entries:

    DT.120836120  DT.97800972  DT.91774531  DT.111277  DT.92066401  DT.91774526  DT.451747  DT.120836141 
    DT.95281620  DT.120836231  DT.97842890  DT.100755229  DT.100775145  DT.120836201  DT.91774518  DT.91798220 
    DT.99977534  DT.102827908  DT.120836131  DT.91774533 

    Selected AceView cDNA sequences (see all 484):

    BG113954 AI699125 CF594260 AA167528 BQ229292 BF593830 CK824087 AI288570 
    CB127946 AW301582 CF528596 BG149517 AI276677 BE937267 BM450515 AA291733 
    BF725677 BQ712421 AA344951 NM_003763 BQ668589 AI468704 BG273079 BQ015099 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STX16 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d
    SP1:        -     -                 -                 -                                                                     
    SP2:                          -     -                 -                                                                     
    SP3:                                                  -           -                                                         
    SP4:                                                  -                             -     -                                 
    SP5:                                                  -           -                                                         


    ECgene alternative splicing isoforms for STX16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STX16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGTGAAGT
    STX16 Expression
    About this image


    STX16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    STX16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STX16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.307913

    UniProtKB/Swiss-Prot: STX16_HUMAN, O14662
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for STX16
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STX16 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stx161 , 5 syntaxin 161, 5 87.49(n)1
    93.85(a)1
      2 (97.85 cM)5
    2289601  NM_172675.41  NP_766263.21 
     1740763085 
    chicken
    (Gallus gallus)
    Aves STX161 syntaxin 16 81.58(n)
    88.58(a)
      419315  NM_001006295.1  NP_001006295.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    85(a)
    1 → many
    GL343475.1(153358-171341)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC690902 hypothetical protein MGC69090 77.14(n)    BC059338.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stx161 syntaxin 16 74.2(n)
    80.07(a)
      562857  XM_686224.4  XP_691316.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syx161 Syntaxin 16 53.59(n)
    46.29(a)
      33034  NM_078696.2  NP_523420.1 
    worm
    (Caenorhabditis elegans)
    Secernentea syn-161 syn-16 44.44(n)
    36.52(a)
      175712  NM_065704.3  NP_498105.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TLG2(YOL018C)4
    TLG21
    Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) less4
    TLG21
    44.2(n)1
    29.02(a)1
      15(292074-290881)4
    8541421, 4  NP_014624.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SYP411 SYP41 50.84(n)
    40.18(a)
      832756  NM_001036873.1  NP_001031950.1 


    ENSEMBL Gene Tree for STX16 (if available)
    TreeFam Gene Tree for STX16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STX16 gene
    STX16-NPEPL12  
    3 SIMAP similar genes for STX16 using alignment to 12 protein entries:     STX16_HUMAN (see all proteins):
    STX16-NPEPL1    STX1B    STX3

    Find genes that share paralogs with STX16           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for STX16 (see all 616)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1431558891,2
    C--54011861(+) CCCCC-/C/GCCCCC 8 -- int10--------
    rs114832041,2
    C--54030911(+) CCTTT-/T/TTA 
            
    ATGTG
    13 -- int1 cds10--------
    rs2020690801,2
    --54030961(+) TGTAT-/ATTAA 
            
    TATTA
    8 -- int10--------
    rs114677811,2
    C--54030963(+) TATAT-/TAATATTA 8 -- int10--------
    rs1841352831,2
    --57193888(+) AGGTGA/TTGAGT 8 -- us2k10--------
    rs1881437021,2
    --57193957(+) ACCAGC/TTCAGT 8 -- us2k10--------
    rs1424685781,2
    --57193996(+) GGGGGA/GAGCGG 8 -- us2k10--------
    rs1465818171,2
    C--57194025(+) GTGCTA/GCTGGG 8 -- us2k10--------
    rs1809679111,2
    --57194145(+) CCCCAA/GGGCCT 8 -- us2k10--------
    rs1870444381,2
    --57194456(+) AAAGCA/GCGGGT 8 -- us2k10--------

    HapMap Linkage Disequilibrium report for STX16 (57226309 - 57254582 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STX16:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1002410CNV Deletion20482838
    nsv828761CNV Loss20364138

    Human Gene Mutation Database (HGMD): STX16
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STX16
    DNA2.0 Custom Variant and Variant Library Synthesis for STX16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603666   
    OMIM disorders: 603233  
    UniProtKB/Swiss-Prot: STX16_HUMAN, O14662
  • Pseudohypoparathyroidism 1B (PHP1B) [MIM:603233]: A disorder characterized by end-organ resistance to
    parathyroid hormone, hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects
    characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides
    resistance to PTH. Note=The gene represented in this entry is involved in disease pathogenesis. Microdeletions
    involving STX16 can cause loss of methylation at exon A/B of GNAS, resulting in PHP1B

  • 4 diseases for STX16:    
    About MalaCards
    pseudohypoparathyroidism type 1b    pseudohypoparathyroidism    albright's hereditary osteodystrophy    cardiovascular disease risk factor

    2 diseases from the University of Copenhagen DISEASES database for STX16:
    Pseudohypoparathyroidism     Hyperphosphatemia

    Find genes that share disorders with STX16           About GenesLikeMe

    2 Novoseek inferred disease relationships for STX16 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pseudohypoparathyroidism, type ib 95.3 3 15800843 (2), 17317779 (1)
    cholera 34 1 17389686 (1)


    Export disorders for STX16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STX16 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with STX16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNAS. (PubMed id 15800843)1, 2, 3, 9 Linglart A.... Bastepe M. (Am. J. Hum. Genet. 2005)
    2. Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins. (PubMed id 9464276)1, 2, 3, 9 Tang B.L.... Ho W. (Biochem. Biophys. Res. Commun. 1998)
    3. Syntaxin-16, a putative Golgi t-SNARE. (PubMed id 9587053)1, 2, 3, 9 Simonsen A.... Stenmark H. (Eur. J. Cell Biol. 1998)
    4. A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells. (PubMed id 18195106)1, 2 Ganley I.G.... Pfeffer S.R. (J. Cell Biol. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins. (PubMed id 17389686)1, 9 Amessou M....Johannes L. (J. Cell. Sci. 2007)
    8. Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network. (PubMed id 15215310)1, 9 Tai G.... Hong W. (Mol. Biol. Cell 2004)
    9. Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network. (PubMed id 19620288)1, 9 PAcrez-Victoria F.J. and Bonifacino J.S. (Mol. Cell. Biol. 2009)
    10. Autosomal dominant pseudohypoparathyroidism type Ib is associated with a heterozygous microdeletion that likely disrupts a putative imprinting control element of GNAS. (PubMed id 14561710)2, 9 Bastepe M.... Jueppner H. (J. Clin. Invest. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8675 HGNC: 11431 AceView: STX16andNPEPL1 Ensembl:ENSG00000124222 euGenes: HUgn8675
    ECgene: STX16 Kegg: 8675 H-InvDB: STX16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STX16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for STX16 gene:
    Search GeneIP for patents involving STX16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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