Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STX16 Gene

Aliases for STX16 Gene

  • Syntaxin 16 2 3 5
  • SYN16 3 4
  • Syntaxin-16 3

External Ids for STX16 Gene

Previous GeneCards Identifiers for STX16 Gene

  • GC20P056955
  • GC20P057864
  • GC20P057912
  • GC20P056659
  • GC20P057226
  • GC20P054010

Summaries for STX16 Gene

Entrez Gene Summary for STX16 Gene

  • This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for STX16 Gene

STX16 (Syntaxin 16) is a Protein Coding gene. Diseases associated with STX16 include Pseudohypoparathyroidism, Type Ib and Pseudohypoparathyroidism. Among its related pathways are Vesicle-mediated transport and Intra-Golgi traffic. GO annotations related to this gene include syntaxin binding and SNAP receptor activity. An important paralog of this gene is STX16-NPEPL1.

UniProtKB/Swiss-Prot for STX16 Gene

  • SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

Gene Wiki entry for STX16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX16 Gene

Genomics for STX16 Gene

Regulatory Elements for STX16 Gene

Enhancers for STX16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F058305 1.5 FANTOM5 ENCODE 3.4 -342.6 -342575 5.4 PKNOX1 ATF1 CREB3L1 SIN3A YBX1 ZNF48 YY1 GLIS2 ELK1 KLF7 NELFCD RAE1 RAB22A PPP4R1L STX16 ANKRD60
GH20F058677 0.4 ENCODE 11.4 +26.8 26767 0.2 GLIS1 REST STX16 STX16-NPEPL1 PIR50186
GH20F059120 1.4 FANTOM5 ENCODE 2.4 +471.3 471260 4.8 PKNOX1 SIN3A FEZF1 FOS SP3 ZHX2 REST TSHZ1 ZNF592 ZNF264 LOC101927932 NELFCD ENSG00000270951 ENSG00000254419 ZNF831 STX16 MRPS16P2
GH20F058980 1.4 FANTOM5 ENCODE 2 +330.7 330675 2.5 HDGF ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 KLF13 SP3 SP5 NELFCD ENSG00000254419 LOC101927932 ZNF831 STX16 GC20M058985
GH20F058660 0.9 FANTOM5 ENCODE 2.8 +10.4 10415 1.5 CBX1 KLF9 ZBTB33 ETV6 NPEPL1 LINC01711 STX16 RAB22A STX16-NPEPL1 PIR50186
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STX16 on UCSC Golden Path with GeneCards custom track

Promoters for STX16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000403716 647 5001 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548

Genomic Location for STX16 Gene

Chromosome:
20
Start:
58,651,253 bp from pter
End:
58,679,526 bp from pter
Size:
28,274 bases
Orientation:
Plus strand

Genomic View for STX16 Gene

Genes around STX16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX16 Gene

Proteins for STX16 Gene

  • Protein details for STX16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14662-STX16_HUMAN
    Recommended name:
    Syntaxin-16
    Protein Accession:
    O14662
    Secondary Accessions:
    • A6NK32
    • A6NN69
    • A8MPP0
    • B7ZBN1
    • B7ZBN2
    • B7ZBN3
    • E1P5M0
    • E1P607
    • O14661
    • O14663
    • O60517
    • Q5W084
    • Q5W086
    • Q5W087
    • Q5XKI6
    • Q6GMS8
    • Q9H0Z0
    • Q9H1T7
    • Q9H1T8
    • Q9UIX5

    Protein attributes for STX16 Gene

    Size:
    325 amino acids
    Molecular mass:
    37031 Da
    Quaternary structure:
    • Interacts with GCC2.
    SequenceCaution:
    • Sequence=AAB69282.1; Type=Frameshift; Positions=142, 163, 165; Evidence={ECO:0000305}; Sequence=AAB69283.1; Type=Frameshift; Positions=142, 163, 165; Evidence={ECO:0000305}; Sequence=AAC05647.1; Type=Frameshift; Positions=142, 163, 165; Evidence={ECO:0000305};

    Alternative splice isoforms for STX16 Gene

neXtProt entry for STX16 Gene

Post-translational modifications for STX16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for STX16 Gene

Domains & Families for STX16 Gene

Gene Families for STX16 Gene

Protein Domains for STX16 Gene

Suggested Antigen Peptide Sequences for STX16 Gene

Graphical View of Domain Structure for InterPro Entry

O14662

UniProtKB/Swiss-Prot:

STX16_HUMAN :
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX16: view

Function for STX16 Gene

Molecular function for STX16 Gene

UniProtKB/Swiss-Prot Function:
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

Gene Ontology (GO) - Molecular Function for STX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IEA,IDA 15215310
GO:0005515 protein binding IPI 18195106
GO:0019905 syntaxin binding IPI 16154903
genes like me logo Genes that share ontologies with STX16: view
genes like me logo Genes that share phenotypes with STX16: view

Human Phenotype Ontology for STX16 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for STX16 Gene

MGI Knock Outs for STX16:

Animal Model Products

miRNA for STX16 Gene

miRTarBase miRNAs that target STX16

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for STX16 Gene

Localization for STX16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX16 Gene

Golgi apparatus membrane; Single-pass type IV membrane protein.
Isoform C: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STX16 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
mitochondrion 3
plasma membrane 2
nucleus 2
endosome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for STX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm IEA,IDA 9587053
GO:0005794 Golgi apparatus IEA,IDA 9464276
GO:0005802 trans-Golgi network IDA 16154903
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with STX16: view

Pathways & Interactions for STX16 Gene

genes like me logo Genes that share pathways with STX16: view

Gene Ontology (GO) - Biological Process for STX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA,IBA --
GO:0006906 vesicle fusion IBA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with STX16: view

No data available for SIGNOR curated interactions for STX16 Gene

Transcripts for STX16 Gene

Unigene Clusters for STX16 Gene

Syntaxin 16:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX16 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - -
SP7: -
SP8: -

Relevant External Links for STX16 Gene

GeneLoc Exon Structure for
STX16
ECgene alternative splicing isoforms for
STX16

Expression for STX16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STX16 Gene

Protein differential expression in normal tissues from HIPED for STX16 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.9) and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STX16 Gene



Protein tissue co-expression partners for STX16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STX16 Gene:

STX16

SOURCE GeneReport for Unigene cluster for STX16 Gene:

Hs.307913

mRNA Expression by UniProt/SwissProt for STX16 Gene:

O14662-STX16_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with STX16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for STX16 Gene

Orthologs for STX16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STX16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STX16 34
  • 99.75 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 94 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia STX16 34 35
  • 92.49 (n)
cow
(Bos Taurus)
Mammalia STX16 34 35
  • 88.62 (n)
mouse
(Mus musculus)
Mammalia Stx16 34 16
  • 87.49 (n)
rat
(Rattus norvegicus)
Mammalia Stx16 34
  • 82.25 (n)
chicken
(Gallus gallus)
Aves STX16 34 35
  • 81.58 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493473 34
  • 75.31 (n)
Str.11454 34
African clawed frog
(Xenopus laevis)
Amphibia MGC69090 34
zebrafish
(Danio rerio)
Actinopterygii stx16 34 35
  • 74.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta Syx16 34 35
  • 53.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000850 34
  • 46.52 (n)
worm
(Caenorhabditis elegans)
Secernentea syn-16 34
  • 44.44 (n)
syx-16 35
  • 30 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL026C 34
  • 46.76 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A10681g 34
  • 44.82 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TLG2 34 35 37
  • 44.2 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SYP41 34
  • 50.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04119 34
  • 46.53 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tlg2 34
  • 42.9 (n)
Species where no ortholog for STX16 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX16 Gene

ENSEMBL:
Gene Tree for STX16 (if available)
TreeFam:
Gene Tree for STX16 (if available)

Paralogs for STX16 Gene

Paralogs for STX16 Gene

genes like me logo Genes that share paralogs with STX16: view

Variants for STX16 Gene

Sequence variations from dbSNP and Humsavar for STX16 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1052642 -- 58,676,474(+) AATGG(G/T)TTTTT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10695175 -- 58,678,657(+) AAAAA(-/AAA)TTGTT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10706096 -- 58,660,714(+) GCTCC(-/T)TTTTT intron-variant
rs111253344 -- 58,659,537(+) GACCA(C/T)GCCTT intron-variant
rs111486683 -- 58,675,983(+) GTAAA(C/T)AAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STX16 Gene

Variant ID Type Subtype PubMed ID
nsv828761 CNV loss 20364138
nsv1063462 CNV gain 25217958
esv1002410 CNV deletion 20482838

Variation tolerance for STX16 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STX16 Gene

Human Gene Mutation Database (HGMD)
STX16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STX16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX16 Gene

Disorders for STX16 Gene

MalaCards: The human disease database

(7) MalaCards diseases for STX16 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pseudohypoparathyroidism, type ib
  • pseudohypoparathyroidism ib
pseudohypoparathyroidism
pseudohypoparathyroidism ia
  • pseudohypoparathyroidism, type ia
pseudopseudohypoparathyroidism
  • normocalcemic pseudohypoparathyroidism [ambiguous]
hyperphosphatemia
- elite association - COSMIC cancer census association via MalaCards
Search STX16 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

STX16_HUMAN
  • Pseudohypoparathyroidism 1B (PHP1B) [MIM:603233]: A disorder characterized by end-organ resistance to parathyroid hormone, hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. {ECO:0000269 PubMed:14561710, ECO:0000269 PubMed:15800843}. Note=The gene represented in this entry is involved in disease pathogenesis. Microdeletions involving STX16 can cause loss of methylation at exon A/B of GNAS, resulting in PHP1B.

Relevant External Links for STX16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STX16
genes like me logo Genes that share disorders with STX16: view

No data available for Genatlas for STX16 Gene

Publications for STX16 Gene

  1. A novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNAS. (PMID: 15800843) Linglart A. … Bastepe M. (Am. J. Hum. Genet. 2005) 2 3 4 22 64
  2. Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins. (PMID: 9464276) Tang B.L. … Ho W. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 22 64
  3. Syntaxin-16, a putative Golgi t-SNARE. (PMID: 9587053) Simonsen A. … Stenmark H. (Eur. J. Cell Biol. 1998) 2 3 4 22 64
  4. Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network. (PMID: 19620288) PAcrez-Victoria F.J. … Bonifacino J.S. (Mol. Cell. Biol. 2009) 3 22 64
  5. A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells. (PMID: 18195106) Ganley I.G. … Pfeffer S.R. (J. Cell Biol. 2008) 3 4 64

Products for STX16 Gene

Sources for STX16 Gene

Content
Loading form....