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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STX16 Gene

protein-coding   GIFtS: 63
GCID: GC20P057226

Syntaxin 16

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Syntaxin 161 2
SYN162 5
syntaxin-162
Syn163

External Ids:    HGNC: 114311   Entrez Gene: 86752   Ensembl: ENSG000001242227   OMIM: 6036665   UniProtKB: O146623   
ORGUL members:         
NONCODE14:n410692 n410691 n410695      

Export aliases for STX16 gene to outside databases

Previous GC identifers: GC20P056955 GC20P057864 GC20P057912 GC20P056659 GC20P054010


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STX16 Gene:
This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These
proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting
specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is
located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found
for this gene. Read-through transcription also exists between this gene and the neighboring downstream
aminopeptidase-like 1 (NPEPL1) gene. (provided by RefSeq, Mar 2011)

GeneCards Summary for STX16 Gene: 
STX16 (syntaxin 16) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with STX16 include pseudohypoparathyroidism, and albright's hereditary osteodystrophy, and among its related super-pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Proteolytic cleavage of SNARE complex proteins. GO annotations related to this gene include protein binding and SNAP receptor activity. An important paralog of this gene is STX16-NPEPL1.

UniProtKB/Swiss-Prot: STX16_HUMAN, O14662
Function: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network

Gene Wiki entry for STX16 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STX16 gene promoter:
         HFH-3   C/EBPbeta   SREBP-1c   Pax-6   Nkx2-5   HNF-3beta   SREBP-1b   C/EBPalpha   FOXI1   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTX16 promoter sequence
   Search SABiosciences Chromatin IP Primers for STX16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.32   Ensembl cytogenetic band:  20q13.32   HGNC cytogenetic band: 20q13.32

STX16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STX16 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P057226:  view genomic region     (about GC identifiers)

Start:
57,226,309 bp from pter      End:
57,254,582 bp from pter
Size:
28,274 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for STX16

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STX16_HUMAN, O14662 (See protein sequence)
Recommended Name: Syntaxin-16  
Size: 325 amino acids; 37031 Da
Subunit: Interacts with GCC2
Subcellular location: Golgi apparatus membrane; Single-pass type IV membrane protein
Subcellular location: Isoform C: Cytoplasm
Sequence caution: Sequence=AAB69282.1; Type=Frameshift; Positions=142, 163, 165; Sequence=AAB69283.1;
Type=Frameshift; Positions=142, 163, 165; Sequence=AAC05647.1; Type=Frameshift; Positions=142, 163, 165;
Secondary accessions: A6NK32 A6NN69 A8MPP0 B7ZBN1 B7ZBN2 B7ZBN3 E1P5M0 E1P607 O14661 O14663
O60517 Q5W084 Q5W086 Q5W087 Q5XKI6 Q6GMS8 Q9H0Z0 Q9H1T7 Q9H1T8 Q9UIX5
Alternative splicing: 6 isoforms:  O14662-1   O14662-2   O14662-3   O14662-4   O14662-5   O14662-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STX16: NX_O14662

Explore proteomics data for STX16 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14662

  • STX16 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STX16 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001001433.1  NP_001128244.1  NP_001128245.1  NP_001191797.1  NP_003754.2  

    ENSEMBL proteins: 
     ENSP00000388348   ENSP00000348229   ENSP00000312086   ENSP00000416852   ENSP00000435118  
     ENSP00000352634   ENSP00000360183   ENSP00000437209   ENSP00000432823   ENSP00000360173  
     ENSP00000434369   ENSP00000350723   ENSP00000432414   ENSP00000436667   ENSP00000401801  
     ENSP00000355408   ENSP00000354445  
    Reactome Protein details: O14662
    Human Recombinant Protein Products for STX16: 
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    Cloud-Clone Corp. Proteins for STX16 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm TAS9587053
    GO:0005794Golgi apparatus TAS9587053
    GO:0016020membrane ----

    STX16 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR000727 T_SNARE_dom
     IPR010989 t-SNARE
     IPR006011 Syntaxin_N
     IPR006012 Syntaxin/epimorphin_CS

    Graphical View of Domain Structure for InterPro Entry O14662

    ProtoNet protein and cluster: O14662

    1 Blocks protein domain: IPB006011 Syntaxin

    UniProtKB/Swiss-Prot: STX16_HUMAN, O14662
    Similarity: Belongs to the syntaxin family
    Similarity: Contains 1 t-SNARE coiled-coil homology domain


    STX16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STX16_HUMAN, O14662
    Function: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005484SNAP receptor activity IDA15215310
    GO:0005515protein binding IPI18195106
         
    STX16 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for STX16:
     Decreased cell number  Decreased viability with pacli 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Stx16):
     normal 

    STX16 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Stx16tm1Hju for STX16

       inGenious Targeting Laboratory - Custom generated mouse model solutions for STX16 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STX16 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STX16 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    SNARE interactions in vesicular transport0.40
    2Botulinum neurotoxicity
    Botulinum neurotoxicity0.89
    Proteolytic cleavage of SNARE complex proteins0.89
    3Transmission across Chemical Synapses
    Neuronal System0.67
    4Clathrin-dependent protein traffic
    Transport Clathrin-coated vesicle cycle0.66
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for STX16
        Transport Clathrin-coated vesicle cycle

    4        Reactome Pathways for STX16
        Proteolytic cleavage of SNARE complex proteins
    Botulinum neurotoxicity
    Neuronal System
    Disease

    1 PharmGKB Pathway for STX16
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    1         Kegg Pathway  (Kegg details for STX16):
        SNARE interactions in vesicular transport


    STX16 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STX16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for STX16 (O146622, 3 ENSP000003601834) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN12Q052092, 3MINT-61774 I2D: score=3 
    VAMP3Q158363, ENSP000000546664I2D: score=3 STRING: ENSP00000054666
    VPS45Q9NRW73, ENSP000003581264I2D: score=2 STRING: ENSP00000358126
    VTI1AQ96AJ93, ENSP000003767924I2D: score=1 STRING: ENSP00000376792
    STX6O437523, ENSP000002583014I2D: score=2 STRING: ENSP00000258301
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006891intra-Golgi vesicle-mediated transport TAS9464276
    GO:0016192vesicle-mediated transport ----
    GO:0042147retrograde transport, endosome to Golgi IDA15215310

    STX16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STX16

    Search CenterWatch for drugs/clinical trials and news about STX16

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STX16 gene (6 alternative transcripts): 
    NM_001001433.2  NM_001134772.2  NM_001134773.2  NM_001204868.1  NM_003763.5  NM_001001434.1  

    Unigene Cluster for STX16:

    Syntaxin 16
    Hs.307913  [show with all ESTs]
    Unigene Representative Sequence: NM_001001433
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000458280 ENST00000355957(uc002xzk.3 uc002xzl.3) ENST00000312283
    ENST00000412911 ENST00000460655 ENST00000359617 ENST00000371141(uc021wfi.1 uc002xzi.3 uc010zzq.2 uc002xzm.3)
    ENST00000476384 ENST00000483434 ENST00000496117 ENST00000490700 ENST00000371132
    ENST00000496003 ENST00000467096 ENST00000358029 ENST00000464640 ENST00000493301
    ENST00000468590
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    Additional mRNA sequence: 

    AF008935.1 AF008936.1 AF038897.1 AF305817.1 AK026970.1 AK026974.1 AK296282.1 AK304867.1 
    AK316547.1 AL359056.1 BC019042.2 BC073876.1 DQ268529.1 DQ272217.1 NR_037941.1 NR_037942.1 
    NR_037943.1 

    20 DOTS entries:

    DT.120836120  DT.97800972  DT.91774531  DT.111277  DT.92066401  DT.91774526  DT.451747  DT.120836141 
    DT.95281620  DT.120836231  DT.97842890  DT.100755229  DT.100775145  DT.120836201  DT.91774518  DT.91798220 
    DT.99977534  DT.102827908  DT.120836131  DT.91774533 

    24/484 AceView cDNA sequences (see all 484):

    BE147200 AW172483 BM894060 NM_001001434 CK824087 NM_003763 AA291733 AI288570 
    BM450515 AI823467 AA167528 W42617 BU844980 AA960975 AV728943 BC019042 
    BQ641592 BQ229292 BU737996 AI276677 BG273079 BQ015099 BQ015638 CF528596 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for STX16 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d
    SP1:        -     -                 -                 -                                                                     
    SP2:                          -     -                 -                                                                     
    SP3:                                                  -           -                                                         
    SP4:                                                  -                             -     -                                 
    SP5:                                                  -           -                                                         


    ECgene alternative splicing isoforms for STX16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STX16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGTGAAGT
    STX16 Expression
    About this image


    See STX16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STX16

    SOURCE GeneReport for Unigene cluster: Hs.307913

    UniProtKB/Swiss-Prot: STX16_HUMAN, O14662
    Tissue specificity: Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STX16 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stx161 , 5 syntaxin 161, 5 87.33(n)1
    93.77(a)1
      2 (97.85 cM)5
    2289601  NM_001102423.11  NP_001095893.11 
     1740763085 
    chicken
    (Gallus gallus)
    Aves STX161 syntaxin 16 81.46(n)
    88.44(a)
      419315  NM_001006295.1  NP_001006295.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    85(a)
    1 → many
    GL343475.1(153358-171341)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC690902 hypothetical protein MGC69090 77.14(n)    BC059338.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stx161 syntaxin 16 73.48(n)
    79.87(a)
      562857  XM_002662535.1  XP_002662581.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syx161 Syntaxin 16 51.97(n)
    43.75(a)
      33034  NM_078696.2  NP_523420.1 
    worm
    (Caenorhabditis elegans)
    Secernentea syn-161 Protein SYN-16 44.7(n)
    35.43(a)
      175712  NM_065704.2  NP_498105.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TLG2(YOL018C)4
    TLG21
    Syntaxin-like t-SNARE that forms a complex with Tlg1p more4
    Tlg2p1
    44.35(n)1
    29.29(a)1
      15(292074-290881)4
    8541421, 4  NP_014624.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SYP411 syntaxin-41 46.42(n)
    35.31(a)
      832756  NM_001036873.1  NP_001031950.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g01163001 hypothetical protein 46.43(n)
    36.61(a)
      4339929  NM_001063154.2  NP_001056619.2 


    ENSEMBL Gene Tree for STX16 (if available)
    TreeFam Gene Tree for STX16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STX16 gene
    STX16-NPEPL12  
    3 SIMAP similar genes for STX16 using alignment to 13 protein entries:     STX16_HUMAN (see all proteins):
    STX16-NPEPL1    STX1B    STX3

    STX16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/616 SNPs in STX16 are shown (see all 616)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1431558891,2
    C--54011861(+) CCCCC-/C/GCCCCC 8 -- int10--------
    rs114832041,2
    C--54030911(+) CCTTT-/T/TTA 
            
    ATGTG
    13 -- int1 cds10--------
    rs2020690801,2
    --54030961(+) TGTAT-/ATTAA 
            
    TATTA
    8 -- int10--------
    rs114677811,2
    C--54030963(+) TATAT-/TAATATTA 8 -- int10--------
    rs1841352831,2
    --57193888(+) AGGTGA/TTGAGT 8 -- us2k10--------
    rs1881437021,2
    --57193957(+) ACCAGC/TTCAGT 8 -- us2k10--------
    rs1424685781,2
    --57193996(+) GGGGGA/GAGCGG 8 -- us2k10--------
    rs1465818171,2
    C--57194025(+) GTGCTA/GCTGGG 8 -- us2k10--------
    rs1809679111,2
    --57194145(+) CCCCAA/GGGCCT 8 -- us2k10--------
    rs1870444381,2
    --57194456(+) AAAGCA/GCGGGT 8 -- us2k10--------

    HapMap Linkage Disequilibrium report for STX16 (57226309 - 57254582 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STX16:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1002410CNV Deletion20482838
    nsv828761CNV Loss20364138


    Human Gene Mutation Database (HGMD): STX16
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing STX16
    DNA2.0 Custom Variant and Variant Library Synthesis for STX16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603666   
    OMIM disorders: 603233  
    UniProtKB/Swiss-Prot: STX16_HUMAN, O14662
  • Pseudohypoparathyroidism 1B (PHP1B) [MIM:603233]: A disorder characterized by end-organ resistance to
    parathyroid hormone, hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects
    characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides
    resistance to PTH. Note=The gene represented in this entry is involved in disease pathogenesis. Microdeletions
    involving STX16 can cause loss of methylation at exon A/B of GNAS, resulting in PHP1B

  • 10 diseases for STX16:    About MalaCards
    pseudohypoparathyroidism    albright's hereditary osteodystrophy    pseudohypoparathyroidism type 1b    cholera
    osteosclerosis    hyperphosphatemia    hypoparathyroidism    brachydactyly
    cystic fibrosis    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for STX16:
    Pseudohypoparathyroidism     Hyperphosphatemia

    STX16 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for STX16 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pseudohypoparathyroidism, type ib 95.3 3 15800843 (2), 17317779 (1)
    cholera 34 1 17389686 (1)


    Export disorders for STX16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STX16 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with STX16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNAS. (PubMed id 15800843)1, 2, 3, 9 Linglart A.... Bastepe M. (2005)
    2. Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins. (PubMed id 9464276)1, 2, 3, 9 Tang B.L.... Ho W. (1998)
    3. Syntaxin-16, a putative Golgi t-SNARE. (PubMed id 9587053)1, 2, 3, 9 Simonsen A....Stenmark H. (1998)
    4. A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells. (PubMed id 18195106)1, 2 Ganley I.G....Pfeffer S.R. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins. (PubMed id 17389686)1, 9 Amessou M....Johannes L. (2007)
    8. Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network. (PubMed id 15215310)1, 9 Tai G.... Hong W. (2004)
    9. Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network. (PubMed id 19620288)1, 9 PAcrez-Victoria F.J. and Bonifacino J.S. (2009)
    10. Autosomal dominant pseudohypoparathyroidism type Ib is associated with a heterozygous microdeletion that likely disrupts a putative imprinting control element of GNAS. (PubMed id 14561710)2, 9 Bastepe M.... Jueppner H. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8675 HGNC: 11431 AceView: STX16andNPEPL1 Ensembl:ENSG00000124222 euGenes: HUgn8675
    ECgene: STX16 Kegg: 8675 H-InvDB: STX16

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STX16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STX16 gene:
    Search GeneIP for patents involving STX16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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