STX12 Gene
protein-coding GIFtS: 60
GCID: GC01P028099
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|
syntaxin 12
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Aliases
for STX12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Syntaxin 121 2 | | STX131 2 | | STX141 2 | | Syntaxin-121 |
Export aliases for STX12 gene to outside databasesPrevious GC identifers: GC01M027314 GC01P027073 GC01P027332 GC01P027704 GC01P027783 GC01P027968 GC01P026355 |
Summaries
for STX12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: STX12_HUMAN, Q86Y82Function: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNAREcomplex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity)
Gene Wiki entry for STX12
|
Genomic Views
for STX12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STX12 gene promoter:
MEF-2A FOXF2 NRF-2 CP2 MyoD aMEF-2 Cdc5 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for STX12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p35.3 Ensembl cytogenetic band: 1p35.3 HGNC cytogenetic band: 1p35.3STX12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P028099: view genomic region
(about GC identifiers)
Start:
|
28,099,694 bp from pter |
End:
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28,150,963 bp from pter |
Size:
|
51,270 bases |
Orientation:
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plus strand |
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Proteins
for STX12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STX12_HUMAN, Q86Y82 (See
protein sequence)Recommended Name: Syntaxin-12 Size: 276 amino acids; 31642 Da
Subunit: Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (Bysimilarity). Associates with the BLOC-1 complex. Interacts with BLOC1S6
Subcellular location: Endosome membrane; Single-pass type IV membrane protein (By similarity). Golgi apparatusmembrane; Single-pass type IV membrane protein (By similarity). Endomembrane system; Single-pass type IV membraneprotein; Cytoplasmic side (Potential)
Sequence caution: Sequence=CAA22911.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from  and Proteopedia  for STX12:2DNX (3D)
Secondary accessions: B1AJQ7 O95564Explore the universe of human proteins at neXtProt for STX12: NX_Q86Y82
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86Y82
STX12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_803173.1
ENSEMBL proteins: ENSP00000363054 ENSP00000392577 Reactome Protein details: Q86Y82
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
STX12 for ontologies About GeneDecksing
STX12 Antibody Products:
Assay Products for STX12: |
Protein
Domains /
Families
for STX12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STX12 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86Y82ProtoNet protein and cluster: Q86Y82 1 Blocks protein family: IPB006011 Syntaxin
UniProtKB/Swiss-Prot: STX12_HUMAN, Q86Y82Similarity: Belongs to the syntaxin familySimilarity: Contains 1 t-SNARE coiled-coil homology domain |
Function
for STX12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STX12_HUMAN, Q86Y82Function: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNAREcomplex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: STX12 (NM_177424) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STX12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX12 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
STX12 for ontologies About GeneDecksing
|
Pathways & Interactions
for STX12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Clathrin-dependent protein traffic | | | 2 | Normal wtCFTR traffic / Sorting endosome formation | | | 3 | Botulinum neurotoxicity | | | 4 | Disease | | | 5 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for STX12
4  GeneGo (Thomson Reuters) Pathways for STX12
4 
Reactome Pathways for STX12
1  PharmGKB Pathway for STX12
1 
Kegg Pathway (Kegg details for STX12):
STX12 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STX12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/44 Interacting proteins for STX12 (Q86Y822, 3 ENSP000003630544) via UniProtKB, MINT, STRING, and/or I2D (see all 44)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
STX12 for ontologies About GeneDecksing
|
Drugs & Compounds
for STX12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STX12
Search CenterWatch for drugs/clinical trials and news about STX12
|
Transcripts
for STX12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STX12 gene: NM_177424.2 Unigene Cluster for STX12: Syntaxin 12 Hs.523855 [show with all ESTs]Unigene Representative Sequence: NM_1774245 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373943(uc001bou.4) ENST00000440806 ENST00000468761 ENST00000481874
ENST00000472285
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STX12 (NM_177424) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STX12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX12 |
Additional cDNA sequence: AF070635.1 AF123769.1 AK095898.1 AK297585.1 AK299982.1 AK309990.1 AK315880.1 AL035306.1 BC046999.1 CR407620.1 15 DOTS entries: DT.445789 DT.100796087 DT.92441232 DT.92441230 DT.100796089 DT.91644949 DT.95343019 DT.121454774 DT.121454778 DT.92441228 DT.100028575 DT.100796084 DT.95089512 DT.95173923 DT.103345 24/366 AceView cDNA sequences (see all 366): AA573169 CN483750 F05268 CA423381 BM478012 AA580137 AA427972 AI859230 AI858449 AI908919 AA127699 AI753380 W37264 BM841359 BM982844 BQ423234 BU729425 AI040281 AI261217 BU674346 CR598864 CA414371 CA430947 AA987790
GeneLoc Exon Structure
|
Expression
for STX12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STX12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTTGTTCT
About this image
See STX12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STX12
SOURCE GeneReport for Unigene cluster: Hs.523855
SABiosciences Custom PCR Arrays for STX12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STX12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STX12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX12 |
Orthologs
for STX12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for STX12 gene from 8/24 species (see all 24) About this table
ENSEMBL Gene Tree for STX12 (if available)
TreeFam Gene Tree for STX12 (if available) |
Paralogs
for STX12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STX12 gene
- TSNARE12 STX72
2 SIMAP similar genes for STX12 using alignment to 3 protein entries: STX12_HUMAN (see all proteins):STX7 TSNARE1
STX12 for paralogs About GeneDecksing
|
Genomic Variants
for STX12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STX12 (28099694 - 28150963 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for STX12: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STX12 |
|
Disorders
/ Diseases
for STX12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STX12 for disorders About GeneDecksing
OMIM gene information: 606892
OMIM disorders: --
5  diseases for STX12: About MalaCardsplatelet storage pool deficiency typhoid fever cholesterol neuronitis
alcoholism
1 disease from the University of Copenhagen DISEASES database for STX12:Typhoid fever Export disorders for STX12 gene to outside databases
|
Publications
for STX12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STX12 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with STX12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Syntaxin 12, a member of the syntaxin family localized to the endosome. (PubMed id 9507000)1, 3, 9 Tang B.L....Hong W. (1998)
- The dysbindin-containing complex (BLOC-1) in brain: d evelopmental regulation, interaction with SNARE proteins and role in neurite ou tgrowth. (PubMed id 19546860)1, 2 Ghiani C.A....Dell'Angelica E.C. (2010)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for STX12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STX12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STX12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STX12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STX12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STX12 gene:
Search GeneIP for patents involving STX12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STX12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for STX12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STX12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STX12 | | | OriGene Protein Over-expression Lysate for STX12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STX12 | | OriGene 3'-UTR Clone for STX12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for STX12 | | OriGene Custom Protein Services for STX12 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STX12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STX12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX12 |
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 |  |  |  | |
| | | | Search Tocris compounds for STX12 |
| |  |  |  |  | | | | | | Recombinant Protein for STX12 |
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 | | | STX12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX12 |
|  |  |  | | | | ThermoFisher Antibodies for STX12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX12 |
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