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Aliases for STX12 Gene

Aliases for STX12 Gene

  • Syntaxin 12 2 3 5
  • STX13 3
  • STX14 3

External Ids for STX12 Gene

Previous GeneCards Identifiers for STX12 Gene

  • GC01M027314
  • GC01P027073
  • GC01P027332
  • GC01P027704
  • GC01P027968
  • GC01P028099
  • GC01P026355

Summaries for STX12 Gene

GeneCards Summary for STX12 Gene

STX12 (Syntaxin 12) is a Protein Coding gene. Among its related pathways are Phagosome and Normal wtCFTR traffic / ER-to-Golgi. GO annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is TSNARE1.

UniProtKB/Swiss-Prot for STX12 Gene

  • SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity).

Gene Wiki entry for STX12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX12 Gene

Genomics for STX12 Gene

Regulatory Elements for STX12 Gene

Enhancers for STX12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STX12 on UCSC Golden Path with GeneCards custom track

Promoters for STX12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STX12 on UCSC Golden Path with GeneCards custom track

Genomic Location for STX12 Gene

Chromosome:
1
Start:
27,773,183 bp from pter
End:
27,824,452 bp from pter
Size:
51,270 bases
Orientation:
Plus strand

Genomic View for STX12 Gene

Genes around STX12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX12 Gene

Proteins for STX12 Gene

  • Protein details for STX12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y82-STX12_HUMAN
    Recommended name:
    Syntaxin-12
    Protein Accession:
    Q86Y82
    Secondary Accessions:
    • B1AJQ7
    • O95564

    Protein attributes for STX12 Gene

    Size:
    276 amino acids
    Molecular mass:
    31642 Da
    Quaternary structure:
    • Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity). Associates with the BLOC-1 complex. Interacts with BLOC1S6.
    SequenceCaution:
    • Sequence=CAA22911.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STX12 Gene

neXtProt entry for STX12 Gene

Proteomics data for STX12 Gene at MOPED

Post-translational modifications for STX12 Gene

  • Ubiquitination at Lys 44 and Lys 58
  • Modification sites at PhosphoSitePlus

Other Protein References for STX12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for STX12 Gene

Domains & Families for STX12 Gene

Gene Families for STX12 Gene

Protein Domains for STX12 Gene

Suggested Antigen Peptide Sequences for STX12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y82

UniProtKB/Swiss-Prot:

STX12_HUMAN :
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX12: view

Function for STX12 Gene

Molecular function for STX12 Gene

UniProtKB/Swiss-Prot Function:
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity).

Gene Ontology (GO) - Molecular Function for STX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IEA,IBA --
genes like me logo Genes that share ontologies with STX12: view
genes like me logo Genes that share phenotypes with STX12: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STX12 Gene

Localization for STX12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX12 Gene

Endosome membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein. Endomembrane system; Single-pass type IV membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX12 Gene COMPARTMENTS Subcellular localization image for STX12 gene
Compartment Confidence
extracellular 5
endosome 4
golgi apparatus 4
cytosol 3
nucleus 2
mitochondrion 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for STX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0016021 integral component of membrane IBA --
GO:0031201 SNARE complex IDA 19546860
GO:0045335 phagocytic vesicle IDA 15469992
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with STX12: view

Pathways & Interactions for STX12 Gene

genes like me logo Genes that share pathways with STX12: view

Gene Ontology (GO) - Biological Process for STX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 vesicle fusion IBA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with STX12: view

No data available for SIGNOR curated interactions for STX12 Gene

Drugs & Compounds for STX12 Gene

No Compound Related Data Available

Transcripts for STX12 Gene

Unigene Clusters for STX12 Gene

Syntaxin 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STX12 Gene

No ASD Table

Relevant External Links for STX12 Gene

GeneLoc Exon Structure for
STX12
ECgene alternative splicing isoforms for
STX12

Expression for STX12 Gene

mRNA expression in normal human tissues for STX12 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX12 Gene



SOURCE GeneReport for Unigene cluster for STX12 Gene Hs.523855

genes like me logo Genes that share expression patterns with STX12: view

Protein tissue co-expression partners for STX12 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STX12 Gene

Orthologs for STX12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STX12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STX12 35
  • 93.07 (n)
  • 95.26 (a)
STX12 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STX12 35
  • 93.67 (n)
  • 95.62 (a)
mouse
(Mus musculus)
Mammalia Stx12 35
  • 91.44 (n)
  • 95.72 (a)
Stx12 16
Stx12 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STX12 35
  • 100 (n)
  • 100 (a)
STX12 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stx12 35
  • 90.4 (n)
  • 94.55 (a)
oppossum
(Monodelphis domestica)
Mammalia STX12 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX12 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves STX12 35
  • 78.61 (n)
  • 87.8 (a)
STX12 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX12 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17795 35
stx12 35
  • 71.87 (n)
  • 79.32 (a)
zebrafish
(Danio rerio)
Actinopterygii stx12 35
  • 69.21 (n)
  • 71.89 (a)
stx12 36
  • 70 (a)
OneToMany
stx12l 36
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Syx7 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea syx-7 35
  • 48.75 (n)
  • 36.92 (a)
syx-7 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP12 36
  • 20 (a)
OneToMany
PEP12 38
bread mold
(Neurospora crassa)
Ascomycetes NCU06777 35
  • 42.82 (n)
  • 30.54 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pep12 35
  • 46.62 (n)
  • 31.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for STX12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX12 Gene

ENSEMBL:
Gene Tree for STX12 (if available)
TreeFam:
Gene Tree for STX12 (if available)

Paralogs for STX12 Gene

Paralogs for STX12 Gene

(2) SIMAP similar genes for STX12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with STX12: view

Variants for STX12 Gene

Sequence variations from dbSNP and Humsavar for STX12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035643 A breast cancer sample
rs8985 -- 27,824,090(+) TAATT(A/T)AAAAA utr-variant-3-prime
rs959450 -- 27,774,654(+) GTGCC(C/T)AGCCT intron-variant
rs766846 -- 27,774,522(+) ACTTT(A/T)AAAaa intron-variant
rs2142625 -- 27,812,690(+) CCCTC(A/G)TCGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STX12 Gene

Variant ID Type Subtype PubMed ID
nsv509069 CNV Insertion 20534489

Variation tolerance for STX12 Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STX12 Gene

Disorders for STX12 Gene

Relevant External Links for STX12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STX12

No disorders were found for STX12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX12 Gene

Publications for STX12 Gene

  1. Syntaxin 12, a member of the syntaxin family localized to the endosome. (PMID: 9507000) Tang B.L. … Hong W. (J. Biol. Chem. 1998) 2 3 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. The Q-soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Q-SNARE) SNAP-47 Regulates Trafficking of Selected Vesicle-associated Membrane Proteins (VAMPs). (PMID: 26359495) Kuster A. … Proux-Gillardeaux V. (J. Biol. Chem. 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for STX12 Gene

Sources for STX12 Gene

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