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STX12 Gene

protein-coding   GIFtS: 61
GCID: GC01P028099

Syntaxin 12

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Syntaxin 121 2
STX132
STX142
syntaxin-122

External Ids:    HGNC: 114301   Entrez Gene: 236732   Ensembl: ENSG000001177587   OMIM: 6068925   UniProtKB: Q86Y823   

Export aliases for STX12 gene to outside databases

Previous GC identifers: GC01M027314 GC01P027073 GC01P027332 GC01P027704 GC01P027783 GC01P027968 GC01P026355


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STX12 Gene:
STX12 (syntaxin 12) is a protein-coding gene. Diseases associated with STX12 include platelet storage pool deficiency, and typhoid fever. GO annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is TSNARE1.

UniProtKB/Swiss-Prot: STX12_HUMAN, Q86Y82
Function: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The
SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity)

Gene Wiki entry for STX12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the STX12 gene promoter:
         MEF-2A   FOXF2   NRF-2   CP2   MyoD   aMEF-2   Cdc5   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTX12 promoter sequence
   Search Chromatin IP Primers for STX12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STX12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.3

STX12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STX12 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P028099:  view genomic region     (about GC identifiers)

Start:
28,099,694 bp from pter      End:
28,150,963 bp from pter
Size:
51,270 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: STX12_HUMAN, Q86Y82 (See protein sequence)
Recommended Name: Syntaxin-12  
Size: 276 amino acids; 31642 Da
Subunit: Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By
similarity). Associates with the BLOC-1 complex. Interacts with BLOC1S6
Sequence caution: Sequence=CAA22911.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for STX12:
2DNX (3D)    
Secondary accessions: B1AJQ7 O95564

Explore the universe of human proteins at neXtProt for STX12: NX_Q86Y82

Explore proteomics data for STX12 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys44, Lys58
  • Modification sites at PhosphoSitePlus

  • See STX12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_803173.1  
    ENSEMBL proteins: 
     ENSP00000363054   ENSP00000392577  

    STX12 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for STX12
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    Novus Biologicals STX12 Proteins
    Novus Biologicals STX12 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for STX12
    Cloud-Clone Corp. Proteins for STX12

    STX12 Antibody Products:

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    STX12 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STX12
    Cloud-Clone Corp. CLIAs for STX12


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000727 T_SNARE_dom
     IPR010989 t-SNARE
     IPR006011 Syntaxin_N
     IPR006012 Syntaxin/epimorphin_CS

    Graphical View of Domain Structure for InterPro Entry Q86Y82

    ProtoNet protein and cluster: Q86Y82

    1 Blocks protein domain: IPB006011 Syntaxin

    UniProtKB/Swiss-Prot: STX12_HUMAN, Q86Y82
    Similarity: Belongs to the syntaxin family
    Similarity: Contains 1 t-SNARE coiled-coil homology domain


    STX12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STX12_HUMAN, Q86Y82
    Function: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The
    SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding IBA--
    GO:0005484SNAP receptor activity IBA--
    GO:0005515protein binding IPI12191018
         
    STX12 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STX12
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STX12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STX12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STX12

    miRNA
    Products:
        
    miRTarBase miRNAs that target STX12:
    hsa-mir-18a-5p (MIRT050667), hsa-mir-26b-5p (MIRT029247), hsa-mir-106b-5p (MIRT044373)

    Block miRNA regulation of human, mouse, rat STX12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STX12 (see all 36):
    hsa-miR-136 hsa-miR-300 hsa-miR-301a hsa-miR-3171 hsa-miR-1244 hsa-miR-23a hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidSTX12 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STX12
    Predesigned siRNA for gene silencing in human, mouse, rat STX12

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for STX12 (see all 6)
    OriGene ORF clones in mouse, rat for STX12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STX12 (NM_177424)
    Sino Biological Human cDNA Clone for STX12
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STX12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX12

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for STX12 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STX12_HUMAN, Q86Y82: Endosome membrane; Single-pass type IV membrane protein (By similarity). Golgi apparatus
    membrane; Single-pass type IV membrane protein (By similarity). Endomembrane system; Single-pass type IV membrane
    protein; Cytoplasmic side (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    golgi apparatus5
    cytosol3
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0010008endosome membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0031083colocalizes with BLOC-1 complex IDA19546860

    STX12 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STX12 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    Transport Clathrin coated vesicle cycle0.66
    2Delta508 CFTR traffic Sorting endosome formation in CF
    Normal wtCFTR traffic Sorting endosome formation0.00
    Delta508 CFTR traffic Sorting endosome formation in CF
    3Transmission across Chemical Synapses
    Neuronal System0.68
    4Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    5Phagosome
    Phagosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 GeneGo (Thomson Reuters) Pathways for STX12
        Normal wtCFTR traffic / Sorting endosome formation
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / Sorting endosome formation in CF
    Transport Clathrin-coated vesicle cycle


    1 PharmGKB Pathway for STX12
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    1 Kegg Pathway  (Kegg details for STX12):
        Phagosome


    STX12 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STX12
    Interactions:

        Search GeneGlobe Interaction Network for STX12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STX12 (Q86Y822, 3 ENSP000003630544) via UniProtKB, MINT, STRING, and/or I2D (see all 142)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VTI1AQ96AJ92, ENSP000003767924MINT-4052274 MINT-4052302 MINT-4052327 MINT-4052351 STRING: ENSP00000376792
    STX6O437522, ENSP000002583014MINT-4052274 MINT-4052302 MINT-4052327 MINT-4052351 STRING: ENSP00000258301
    VAMP4O753792MINT-4052274 MINT-4052302 MINT-4052327 MINT-4052351
    NSFP464593, ENSP000003812934I2D: score=3 STRING: ENSP00000381293
    HOMER1Q86YM73, ENSP000003343824I2D: score=2 STRING: ENSP00000334382
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IBA--
    GO:0016079synaptic vesicle exocytosis IBA--
    GO:0016192vesicle-mediated transport ----
    GO:0033344cholesterol efflux IDA15469992
    GO:0050821protein stabilization IDA15469992

    STX12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STX12



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STX12 gene: 
    NM_177424.2  

    Unigene Cluster for STX12:

    Syntaxin 12
    Hs.523855  [show with all ESTs]
    Unigene Representative Sequence: NM_177424
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373943(uc001bou.4) ENST00000440806 ENST00000468761 ENST00000481874
    ENST00000472285
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STX12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STX12 (see all 36):
    hsa-miR-136 hsa-miR-300 hsa-miR-301a hsa-miR-3171 hsa-miR-1244 hsa-miR-23a hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidSTX12 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STX12
    Predesigned siRNA for gene silencing in human, mouse, rat STX12
    Clone
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    OriGene clones in human, mouse for STX12 (see all 6)
    OriGene ORF clones in mouse, rat for STX12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STX12 (NM_177424)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STX12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX12
    Primer
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    OriGene qPCR primer pairs and template standards for STX12
    OriGene qSTAR qPCR primer pairs in human, mouse for STX12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STX12
      QuantiTect SYBR Green Assays in human, mouse, rat STX12
      QuantiFast Probe-based Assays in human, mouse, rat STX12

    Additional mRNA sequence: 

    AF070635.1 AF123769.1 AK095898.1 AK297585.1 AK299982.1 AK309990.1 AK315880.1 AL035306.1 
    BC046999.1 CR407620.1 

    16 DOTS entries:

    DT.445789  DT.100796087  DT.92441232  DT.92441230  DT.100796089  DT.91644949  DT.92441228  DT.95343019 
    DT.121454774  DT.121454778  DT.100028575  DT.100796084  DT.40288469  DT.95089512  DT.95173923  DT.103345 

    Selected AceView cDNA sequences (see all 366):

    Z42005 BQ428103 CR609308 CA430947 AA427972 CB054803 BM841359 C21023 
    BF439367 CA423381 CD657522 AI858449 W37264 CD110049 AL700242 F01523 
    AI816321 AI380177 AA573169 F08176 F06555 CA414371 F04411 AI373651 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STX12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTGTTCT
    STX12 Expression
    About this image

    STX12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STX12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523855
        Custom PCR Arrays for STX12
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat STX12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for STX12 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stx121 , 5 syntaxin 121, 5 91.44(n)1
    95.72(a)1
      4 (66.01 cM)5
    1002261  NM_133887.41  NP_598648.11 
     1328535015 
    chicken
    (Gallus gallus)
    Aves STX121 syntaxin 12 78.61(n)
    87.8(a)
      769300  XM_001232001.3  XP_001232002.1 
    lizard
    (Anolis carolinensis)
    Reptilia STX126
    syntaxin 12
    85(a)
    1 ↔ 1
    GL343743.1(16295-21765)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.177952 Transcribed sequence with weak similarity to protein more 77.08(n)    CF241531.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stx121 syntaxin 12 69.21(n)
    71.89(a)
      415141  NM_001002051.1  NP_001002051.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syx76
    Syntaxin 7
    30(a)
    1 → many
    3L(21438934-21441228)
    worm
    (Caenorhabditis elegans)
    Secernentea syx-71 syx-7 48.75(n)
    36.92(a)
      172718  NM_060021.5  NP_492422.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PEP12(YOR036W)4 Target membrane receptor (t-SNARE) for vesicular intermediates more   --   15(400348-401214) 854201  NP_014679.1 


    ENSEMBL Gene Tree for STX12 (if available)
    TreeFam Gene Tree for STX12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STX12 gene
    TSNARE12  STX72  
    2 SIMAP similar genes for STX12 using alignment to 3 protein entries:     STX12_HUMAN (see all proteins):
    STX7    TSNARE1

    STX12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STX12 (see all 941)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356434
    A breast cancer sample4--see VAR_0356432 P R mis40--------
    rs1422333211,2
    C--28097737(+) AAAATA/GTCTTT 1 -- us2k10--------
    rs1923782191,2
    --28097786(+) AAAAAA/TCATCA 1 -- us2k10--------
    rs1843348491,2
    --28097968(+) CTGAGA/GTCAGG 1 -- us2k10--------
    rs1895756671,2
    C--28098328(+) GGGTGA/GATTGC 1 -- us2k10--------
    rs1811117341,2
    --28098385(+) CAACAC/TTACAA 1 -- us2k10--------
    rs120831881,2
    C,F,H--28098388(+) cactaC/Taaaaa 1 -- us2k1 tfbs35Minor allele frequency- T:0.07NS EA WA 518
    rs1846803341,2
    --28098457(+) AGGTGG/TTAGGA 1 -- us2k10--------
    rs1890511621,2
    --28098518(+) GCACTC/TCAACC 1 -- us2k10--------
    rs75375491,2
    C,F,H--28098587(+) CCATAT/CACAGG 1 -- us2k115Minor allele frequency- C:0.05NS EA NA WA 1620

    HapMap Linkage Disequilibrium report for STX12 (28099694 - 28150963 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for STX12:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509069CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STX12
    DNA2.0 Custom Variant and Variant Library Synthesis for STX12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606892    OMIM disorders: --

    5 diseases for STX12:    About MalaCards
    platelet storage pool deficiency    typhoid fever    breast and colorectal cancer    neuronitis
    colorectal cancer


    STX12 for disorders           About GeneDecksing


    Export disorders for STX12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STX12 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with STX12)
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    1. Syntaxin 12, a member of the syntaxin family localized to the endosome. (PubMed id 9507000)1, 3, 9 Tang B.L....Hong W. (J. Biol. Chem. 1998)
    2. The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth. (PubMed id 19546860)1, 2 Ghiani C.A....Dell'Angelica E.C. (Mol. Psychiatry 2010)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23673 HGNC: 11430 AceView: STX12 Ensembl:ENSG00000117758 euGenes: HUgn23673
    ECgene: STX12 Kegg: 23673 H-InvDB: STX12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STX12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STX12 gene:
    Search GeneIP for patents involving STX12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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