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Aliases for STX12 Gene

Aliases for STX12 Gene

  • Syntaxin 12 2 3
  • Syntaxin-12 3
  • STX13 3
  • STX14 3

External Ids for STX12 Gene

Previous GeneCards Identifiers for STX12 Gene

  • GC01M027314
  • GC01P027073
  • GC01P027332
  • GC01P027704
  • GC01P027968
  • GC01P028099
  • GC01P026355

Summaries for STX12 Gene

GeneCards Summary for STX12 Gene

STX12 (Syntaxin 12) is a Protein Coding gene. Diseases associated with STX12 include platelet storage pool deficiency. Among its related pathways are Disease and Transmission across Chemical Synapses. GO annotations related to this gene include SNAP receptor activity and SNARE binding. An important paralog of this gene is TSNARE1.

UniProtKB/Swiss-Prot for STX12 Gene

  • SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity).

Gene Wiki entry for STX12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX12 Gene

Genomics for STX12 Gene

Regulatory Elements for STX12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STX12 Gene

Start:
27,773,183 bp from pter
End:
27,824,452 bp from pter
Size:
51,270 bases
Orientation:
Plus strand

Genomic View for STX12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STX12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX12 Gene

Proteins for STX12 Gene

  • Protein details for STX12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y82-STX12_HUMAN
    Recommended name:
    Syntaxin-12
    Protein Accession:
    Q86Y82
    Secondary Accessions:
    • B1AJQ7
    • O95564

    Protein attributes for STX12 Gene

    Size:
    276 amino acids
    Molecular mass:
    31642 Da
    Quaternary structure:
    • Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity). Associates with the BLOC-1 complex. Interacts with BLOC1S6.
    SequenceCaution:
    • Sequence=CAA22911.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STX12 Gene

neXtProt entry for STX12 Gene

Proteomics data for STX12 Gene at MOPED

Post-translational modifications for STX12 Gene

  • Ubiquitination at Lys44 and Lys58
  • Modification sites at PhosphoSitePlus

Other Protein References for STX12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STX12 Gene

Domains for STX12 Gene

Protein Domains for STX12 Gene

Suggested Antigen Peptide Sequences for STX12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y82

UniProtKB/Swiss-Prot:

STX12_HUMAN :
  • Q86Y82
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX12: view

No data available for Gene Families for STX12 Gene

Function for STX12 Gene

Molecular function for STX12 Gene

UniProtKB/Swiss-Prot Function: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity).

Gene Ontology (GO) - Molecular Function for STX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 12191018
genes like me logo Genes that share ontologies with STX12: view

Animal Model Products

miRNA for STX12 Gene

miRTarBase miRNAs that target STX12

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STX12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for STX12 Gene

Localization for STX12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX12 Gene

Endosome membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein. Endomembrane system; Single-pass type IV membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX12 Gene COMPARTMENTS Subcellular localization image for STX12 gene
Compartment Confidence
endosome 5
golgi apparatus 5
cytosol 3
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for STX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005768 endosome --
GO:0005794 Golgi apparatus --
GO:0010008 endosome membrane IEA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with STX12: view

Pathways for STX12 Gene

genes like me logo Genes that share pathways with STX12: view

Gene Ontology (GO) - Biological Process for STX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006906 vesicle fusion IBA --
GO:0016079 synaptic vesicle exocytosis --
GO:0016192 vesicle-mediated transport --
GO:0033344 cholesterol efflux IDA 15469992
genes like me logo Genes that share ontologies with STX12: view

Transcripts for STX12 Gene

Unigene Clusters for STX12 Gene

Syntaxin 12:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STX12

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX12 Gene

No ASD Table

Relevant External Links for STX12 Gene

GeneLoc Exon Structure for
STX12
ECgene alternative splicing isoforms for
STX12

Expression for STX12 Gene

mRNA expression in normal human tissues for STX12 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX12 Gene

SOURCE GeneReport for Unigene cluster for STX12 Gene Hs.523855

genes like me logo Genes that share expressions with STX12: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STX12 Gene

Orthologs for STX12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STX12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STX12 35
  • 100 (n)
  • 100 (a)
STX12 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STX12 35
  • 93.07 (n)
  • 95.26 (a)
STX12 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STX12 35
  • 93.67 (n)
  • 95.62 (a)
mouse
(Mus musculus)
Mammalia Stx12 35
  • 91.44 (n)
  • 95.72 (a)
Stx12 16
Stx12 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STX12 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX12 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stx12 35
  • 90.4 (n)
  • 94.55 (a)
chicken
(Gallus gallus)
Aves STX12 35
  • 78.61 (n)
  • 87.8 (a)
STX12 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX12 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17795 35
stx12 35
  • 71.87 (n)
  • 79.32 (a)
zebrafish
(Danio rerio)
Actinopterygii stx12 35
  • 69.21 (n)
  • 71.89 (a)
stx12 36
  • 70 (a)
OneToMany
stx12l 36
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Syx7 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea syx-7 35
  • 48.75 (n)
  • 36.92 (a)
syx-7 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP12 36
  • 20 (a)
OneToMany
PEP12 38
bread mold
(Neurospora crassa)
Ascomycetes NCU06777 35
  • 42.82 (n)
  • 30.54 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pep12 35
  • 46.62 (n)
  • 31.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for STX12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX12 Gene

ENSEMBL:
Gene Tree for STX12 (if available)
TreeFam:
Gene Tree for STX12 (if available)

Paralogs for STX12 Gene

Paralogs for STX12 Gene

Selected SIMAP similar genes for STX12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with STX12: view

Variants for STX12 Gene

Sequence variations from dbSNP and Humsavar for STX12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8985 -- 27,824,090(+) TAATT(A/T)AAAAA utr-variant-3-prime
rs766846 -- 27,774,522(+) ACTTT(A/T)AAAaa intron-variant
rs959450 -- 27,774,654(+) GTGCC(C/T)AGCCT intron-variant
rs2064071 -- 27,779,591(+) cctcc(C/G)aaagt intron-variant
rs2064072 -- 27,779,722(+) TTGCT(A/G)GGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STX12 Gene

Variant ID Type Subtype PubMed ID
nsv509069 CNV Insertion 20534489

Relevant External Links for STX12 Gene

HapMap Linkage Disequilibrium report
STX12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX12 Gene

Disorders for STX12 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for STX12 Gene including...

Search for STX12 Gene in MalaCards »
genes like me logo Genes that share disorders with STX12: view

No data available for UniProtKB/Swiss-Prot for STX12 Gene

Publications for STX12 Gene

  1. Syntaxin 12, a member of the syntaxin family localized to the endosome. (PMID: 9507000) Tang B.L. … Hong W. (J. Biol. Chem. 1998) 2 3 23
  2. The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth. (PMID: 19546860) Ghiani C.A. … Dell'Angelica E.C. (Mol. Psychiatry 2010) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for STX12 Gene

Sources for STX12 Gene

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