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Aliases for STX11 Gene

Aliases for STX11 Gene

  • Syntaxin 11 2 3 5
  • HPLH4 3
  • FHL4 3
  • HLH4 3

External Ids for STX11 Gene

Previous GeneCards Identifiers for STX11 Gene

  • GC06P144094
  • GC06P144318
  • GC06P144406
  • GC06P144452
  • GC06P144513
  • GC06P142035

Summaries for STX11 Gene

Entrez Gene Summary for STX11 Gene

  • This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for STX11 Gene

STX11 (Syntaxin 11) is a Protein Coding gene. Diseases associated with STX11 include hemophagocytic lymphohistiocytosis, familial, 4 and hemophagocytic lymphohistiocytosis. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. GO annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is STX1B.

UniProtKB/Swiss-Prot for STX11 Gene

  • SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.

Gene Wiki entry for STX11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX11 Gene

Genomics for STX11 Gene

Regulatory Elements for STX11 Gene

Enhancers for STX11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STX11 on UCSC Golden Path with GeneCards custom track

Genomic Location for STX11 Gene

Chromosome:
6
Start:
144,140,051 bp from pter
End:
144,191,939 bp from pter
Size:
51,889 bases
Orientation:
Plus strand

Genomic View for STX11 Gene

Genes around STX11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX11 Gene

Proteins for STX11 Gene

  • Protein details for STX11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75558-STX11_HUMAN
    Recommended name:
    Syntaxin-11
    Protein Accession:
    O75558
    Secondary Accessions:
    • E1P598
    • O75378
    • O95148
    • Q5TCL6

    Protein attributes for STX11 Gene

    Size:
    287 amino acids
    Molecular mass:
    33196 Da
    Quaternary structure:
    • Interacts with the SNARE proteins SNAP-23 and VAMP.

neXtProt entry for STX11 Gene

Proteomics data for STX11 Gene at MOPED

Post-translational modifications for STX11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STX11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for STX11 Gene

Domains & Families for STX11 Gene

Gene Families for STX11 Gene

Protein Domains for STX11 Gene

Suggested Antigen Peptide Sequences for STX11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75558

UniProtKB/Swiss-Prot:

STX11_HUMAN :
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX11: view

Function for STX11 Gene

Molecular function for STX11 Gene

UniProtKB/Swiss-Prot Function:
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.

Gene Ontology (GO) - Molecular Function for STX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IEA --
genes like me logo Genes that share ontologies with STX11: view
genes like me logo Genes that share phenotypes with STX11: view

Human Phenotype Ontology for STX11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for STX11 Gene

MGI Knock Outs for STX11:

Animal Model Products

miRNA for STX11 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for STX11 Gene

Localization for STX11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX11 Gene

Membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX11 Gene COMPARTMENTS Subcellular localization image for STX11 gene
Compartment Confidence
plasma membrane 4
cytosol 3
golgi apparatus 3
nucleus 2
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for STX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle IBA --
GO:0012505 endomembrane system IBA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with STX11: view

Pathways & Interactions for STX11 Gene

genes like me logo Genes that share pathways with STX11: view

Pathways by source for STX11 Gene

1 KEGG pathway for STX11 Gene

Gene Ontology (GO) - Biological Process for STX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with STX11: view

No data available for SIGNOR curated interactions for STX11 Gene

Drugs & Compounds for STX11 Gene

No Compound Related Data Available

Transcripts for STX11 Gene

Unigene Clusters for STX11 Gene

Syntaxin 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STX11 Gene

No ASD Table

Relevant External Links for STX11 Gene

GeneLoc Exon Structure for
STX11
ECgene alternative splicing isoforms for
STX11

Expression for STX11 Gene

mRNA expression in normal human tissues for STX11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STX11 Gene

This gene is overexpressed in Whole Blood (x18.7).

Protein differential expression in normal tissues from HIPED for STX11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.0) and Platelet (24.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX11 Gene



SOURCE GeneReport for Unigene cluster for STX11 Gene Hs.118958

genes like me logo Genes that share expression patterns with STX11: view

Protein tissue co-expression partners for STX11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for STX11 Gene

Orthologs for STX11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STX11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STX11 35
  • 87.76 (n)
  • 83.22 (a)
STX11 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STX11 35
  • 89.86 (n)
  • 82.87 (a)
STX11 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stx11 35
  • 86.71 (n)
  • 85.31 (a)
Stx11 16
Stx11 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STX11 35
  • 99.77 (n)
  • 99.3 (a)
STX11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stx11 35
  • 90.71 (n)
  • 93.57 (a)
oppossum
(Monodelphis domestica)
Mammalia STX11 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX11 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves STX11 35
  • 62.29 (n)
  • 59.93 (a)
STX11 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX11 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stx11 35
  • 63.02 (n)
  • 67.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18360 35
zebrafish
(Danio rerio)
Actinopterygii stx11a 35
  • 60.12 (n)
  • 51.93 (a)
stx11a 36
  • 49 (a)
OneToMany
stx11b.1 36
  • 42 (a)
OneToMany
stx11b.2 36
  • 37 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Syx4 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea syx-2 36
  • 18 (a)
ManyToMany
syx-3 36
  • 17 (a)
ManyToMany
syx-4 36
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSO1 36
  • 19 (a)
ManyToMany
SSO2 36
  • 19 (a)
ManyToMany
Species with no ortholog for STX11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX11 Gene

ENSEMBL:
Gene Tree for STX11 (if available)
TreeFam:
Gene Tree for STX11 (if available)

Paralogs for STX11 Gene

Paralogs for STX11 Gene

(9) SIMAP similar genes for STX11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STX11: view

Variants for STX11 Gene

Sequence variations from dbSNP and Humsavar for STX11 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1802414 - 144,186,718(+) CCCAC(A/C/G)AGGAC reference, missense
rs1133248 - 144,187,238(-) CGTTG(A/G/T)GGGCG reference, missense
rs17073498 - 144,186,773(+) CATCC(A/G)GGACA reference, missense
rs9496891 - 144,187,456(+) GCCGG(A/G)CCCTC reference, missense
rs1322452 -- 144,155,154(-) GGACA(C/T)AATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STX11 Gene

Variant ID Type Subtype PubMed ID
nsv507367 CNV Insertion 20534489
nsv830831 CNV Gain 17160897

Variation tolerance for STX11 Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STX11 Gene

HapMap Linkage Disequilibrium report
STX11
Human Gene Mutation Database (HGMD)
STX11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX11 Gene

Disorders for STX11 Gene

MalaCards: The human disease database

(4) MalaCards diseases for STX11 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hemophagocytic lymphohistiocytosis, familial, 4
  • hlh4
hemophagocytic lymphohistiocytosis
  • haemophagocytic syndrome
lymphatic system disease
  • adenopathy
good syndrome
  • thymoma with hypogammaglobulinemia
- elite association - COSMIC cancer census association via MalaCards
Search STX11 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

STX11_HUMAN
  • Familial hemophagocytic lymphohistiocytosis 4 (FHL4) [MIM:603552]: A rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia. {ECO:0000269 PubMed:15703195}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for STX11

Genetic Association Database (GAD)
STX11
Human Genome Epidemiology (HuGE) Navigator
STX11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STX11
genes like me logo Genes that share disorders with STX11: view

No data available for Genatlas for STX11 Gene

Publications for STX11 Gene

  1. Seven novel mammalian SNARE proteins localize to distinct membrane compartments. (PMID: 9553086) Advani R.J. … Scheller R.H. (J. Biol. Chem. 1998) 2 3 4 67
  2. STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America. (PMID: 20486178) Marsh R.A. … Zhang K. (Pediatr Blood Cancer 2010) 3 23
  3. Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11. (PMID: 19804848) zur Stadt U. … Hennies H.C. (Am. J. Hum. Genet. 2009) 3 23
  4. Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients. (PMID: 17525286) Bryceson Y.T. … Ljunggren H.G. (Blood 2007) 3 23
  5. Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity. (PMID: 17785771) Arneson L.N. … Leibson P.J. (J. Immunol. 2007) 3 23

Products for STX11 Gene

Sources for STX11 Gene

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