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Aliases for STX11 Gene

Aliases for STX11 Gene

  • Syntaxin 11 2 3
  • HPLH4 3 6
  • FHL4 3 6
  • HLH4 3 6
  • Syntaxin-11 3

External Ids for STX11 Gene

Previous GeneCards Identifiers for STX11 Gene

  • GC06P144094
  • GC06P144318
  • GC06P144406
  • GC06P144452
  • GC06P144513
  • GC06P142035

Summaries for STX11 Gene

Entrez Gene Summary for STX11 Gene

  • This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for STX11 Gene

STX11 (Syntaxin 11) is a Protein Coding gene. Diseases associated with STX11 include hemophagocytic lymphohistiocytosis, familial, 4 and hemophagocytic lymphohistiocytosis. Among its related pathways are Disease and Transmission across Chemical Synapses. GO annotations related to this gene include SNAP receptor activity. An important paralog of this gene is STX4.

UniProtKB/Swiss-Prot for STX11 Gene

  • SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network

Gene Wiki entry for STX11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX11 Gene

Genomics for STX11 Gene

Regulatory Elements for STX11 Gene

Genomic Location for STX11 Gene

144,150,440 bp from pter
144,191,939 bp from pter
41,500 bases
Plus strand

Genomic View for STX11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STX11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX11 Gene

Proteins for STX11 Gene

  • Protein details for STX11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • E1P598
    • O75378
    • O95148
    • Q5TCL6

    Protein attributes for STX11 Gene

    287 amino acids
    Molecular mass:
    33196 Da
    Quaternary structure:
    • Interacts with the SNARE proteins SNAP-23 and VAMP

neXtProt entry for STX11 Gene

Proteomics data for STX11 Gene at MOPED

Post-translational modifications for STX11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STX11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STX11 Gene

Domains for STX11 Gene

Protein Domains for STX11 Gene

Suggested Antigen Peptide Sequences for STX11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O75558
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX11: view

No data available for Gene Families for STX11 Gene

Function for STX11 Gene

Molecular function for STX11 Gene

UniProtKB/Swiss-Prot Function: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network

Gene Ontology (GO) - Molecular Function for STX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with STX11: view
genes like me logo Genes that share phenotypes with STX11: view

Animal Models for STX11 Gene

MGI Knock Outs for STX11:

miRNA for STX11 Gene

miRTarBase miRNAs that target STX11

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for STX11 Gene

Localization for STX11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX11 Gene

Membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for STX11 Gene COMPARTMENTS Subcellular localization image for STX11 gene
Compartment Confidence
cytosol 3
golgi apparatus 3
nucleus 2
plasma membrane 2
endosome 1

Gene Ontology (GO) - Cellular Components for STX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IBA --
GO:0008021 synaptic vesicle IBA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with STX11: view

Pathways for STX11 Gene

genes like me logo Genes that share pathways with STX11: view

Pathways by source for STX11 Gene

2 Reactome pathways for STX11 Gene
1 KEGG pathway for STX11 Gene

Gene Ontology (GO) - Biological Process for STX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001913 T cell mediated cytotoxicity --
GO:0006886 intracellular protein transport IBA --
GO:0016192 vesicle-mediated transport --
GO:0031629 synaptic vesicle fusion to presynaptic membrane IBA --
GO:0042267 natural killer cell mediated cytotoxicity --
genes like me logo Genes that share ontologies with STX11: view

Transcripts for STX11 Gene

Unigene Clusters for STX11 Gene

Syntaxin 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STX11 Gene

No ASD Table

Relevant External Links for STX11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STX11 Gene

mRNA expression in normal human tissues for STX11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STX11 Gene

This gene is overexpressed in Whole Blood (18.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX11 Gene

SOURCE GeneReport for Unigene cluster for STX11 Gene Hs.118958

genes like me logo Genes that share expressions with STX11: view

No data available for mRNA Expression by UniProt/SwissProt for STX11 Gene

Orthologs for STX11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STX11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STX11 35
  • 99.77 (n)
  • 99.3 (a)
STX11 36
  • 99 (a)
(Bos Taurus)
Mammalia STX11 35
  • 87.76 (n)
  • 83.22 (a)
STX11 36
  • 83 (a)
(Canis familiaris)
Mammalia STX11 35
  • 89.86 (n)
  • 82.87 (a)
STX11 36
  • 83 (a)
(Mus musculus)
Mammalia Stx11 35
  • 86.71 (n)
  • 85.31 (a)
Stx11 16
Stx11 36
  • 85 (a)
(Monodelphis domestica)
Mammalia STX11 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia STX11 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Stx11 35
  • 90.71 (n)
  • 93.57 (a)
(Gallus gallus)
Aves STX11 35
  • 62.29 (n)
  • 59.93 (a)
STX11 36
  • 58 (a)
(Anolis carolinensis)
Reptilia STX11 36
  • 60 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18360 35
tropical clawed frog
(Silurana tropicalis)
Amphibia stx11 35
  • 63.02 (n)
  • 67.14 (a)
(Danio rerio)
Actinopterygii stx11a 35
  • 60.12 (n)
  • 51.93 (a)
stx11a 36
  • 49 (a)
stx11b.1 36
  • 42 (a)
stx11b.2 36
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syx4 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea syx-2 36
  • 18 (a)
syx-3 36
  • 17 (a)
syx-4 36
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSO1 36
  • 19 (a)
SSO2 36
  • 19 (a)
Species with no ortholog for STX11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX11 Gene

Gene Tree for STX11 (if available)
Gene Tree for STX11 (if available)

Paralogs for STX11 Gene

Paralogs for STX11 Gene

Selected SIMAP similar genes for STX11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STX11: view

Variants for STX11 Gene

Sequence variations from dbSNP and Humsavar for STX11 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs873412 -- 144,167,653(-) caaca(C/G)agcaa intron-variant
rs960245 -- 144,180,194(-) TAAGC(A/C)AATTT intron-variant
rs1133248 - 144,187,238(-) CGTTG(A/T)GGGCG missense, reference
rs1322452 -- 144,155,154(-) GGACA(C/T)AATGG intron-variant
rs1570323 -- 144,183,540(-) AAAAA(C/T)TGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STX11 Gene

Variant ID Type Subtype PubMed ID
nsv507367 CNV Insertion 20534489
nsv830831 CNV Gain 17160897

Relevant External Links for STX11 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX11 Gene

Disorders for STX11 Gene

(1) OMIM Diseases for STX11 Gene (605014)


  • Familial hemophagocytic lymphohistiocytosis 4 (FHL4) [MIM:603552]: A rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia. {ECO:0000269 PubMed:15703195}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for STX11 Gene

(1) Novoseek inferred disease relationships for STX11 Gene

Disease -log(P) Hits PubMed IDs
familial hemophagocytic lymphohistiocytosis 94.6 4

Relevant External Links for STX11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with STX11: view

Publications for STX11 Gene

  1. Syntaxin 11: a member of the syntaxin family without a carboxyl terminal transmembrane domain. (PMID: 9571206) Tang B.L. … Hong W. (Biochem. Biophys. Res. Commun. 1998) 3 4 23
  2. Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network. (PMID: 10036234) Valdez A.C. … Roche P.A. (J. Cell Sci. 1999) 3 4 23
  3. Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11. (PMID: 15703195) zur Stadt U. … Hennies H.C. (Hum. Mol. Genet. 2005) 3 4 23
  4. Seven novel mammalian SNARE proteins localize to distinct membrane compartments. (PMID: 9553086) Advani R.J. … Scheller R.H. (J. Biol. Chem. 1998) 2 3 4
  5. Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients. (PMID: 17525286) Bryceson Y.T. … Ljunggren H.G. (Blood 2007) 3 23

Products for STX11 Gene

Sources for STX11 Gene

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