STX10 Gene
protein-coding GIFtS: 52
GCID: GC19M013254
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|
syntaxin 10
| |
Aliases
for STX10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Syntaxin 101 2 | | SYN101 2 3 | | Hsyn101 | | Syntaxin-101 | | Syn103 |
Export aliases for STX10 gene to outside databasesPrevious GC identifers: GC19M013587 GC19M013100 GC19M013116 GC19M013115 GC19M012827 |
Summaries
for STX10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for STX10:
This gene belongs to the syntaxin family and encodes a soluble N-ethylmaleimide sensitive factor attachment proteinreceptor (SNARE). The encoded protein is involved in docking and fusion events at the Golgi apparatus. Alternativesplicing results in multiple transcript variants. (provided by RefSeq, Oct 2012)
UniProtKB/Swiss-Prot: STX10_HUMAN, O60499Function: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network
Gene Wiki entry for STX10
|
Genomic Views
for STX10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STX10 gene promoter:
NRSF form 1 ATF-2 Lmo2 NRSF form 2 NF-kappaB CREB CRE-BP1 Nkx6-1 deltaCREB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for STX10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.13STX10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M013254: view genomic region
(about GC identifiers)
Start:
|
13,254,872 bp from pter |
End:
|
13,261,197 bp from pter |
Size:
|
6,326 bases |
Orientation:
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minus strand |
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Proteins
for STX10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STX10_HUMAN, O60499 (See
protein sequence)Recommended Name: Syntaxin-10 Size: 249 amino acids; 28114 Da
Subunit: Interacts with VPS52
Subcellular location: Golgi apparatus membrane; Single-pass type IV membrane protein (Potential)
1 PDB 3D structure from  and Proteopedia  for STX10:4DND (3D)
Secondary accessions: A6NC41 Q6IAP4 Q96AE8Alternative splicing: 2 isoforms: O60499-1 O60499-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for STX10: NX_O60499
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60499
STX10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001258538.1 NP_001258539.1 NP_001258540.1 NP_003756.1
ENSEMBL proteins: ENSP00000465495 ENSP00000339350 ENSP00000464943 ENSP00000242770 ENSP00000465398 ENSP00000466298 ENSP00000466272 ENSP00000415176 ENSP00000467479 ENSP00000467713 ENSP00000464970 Reactome Protein details: O60499
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
STX10 for ontologies About GeneDecksing
STX10 Antibody Products:
Assay Products for STX10: |
Protein
Domains /
Families
for STX10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STX10 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60499ProtoNet protein and cluster: O60499 UniProtKB/Swiss-Prot: STX10_HUMAN, O60499Similarity: Belongs to the syntaxin familySimilarity: Contains 1 t-SNARE coiled-coil homology domain |
Function
for STX10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STX10_HUMAN, O60499Function: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX10
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX10 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: STX10 (NM_003765) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STX10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX10 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005484 | SNAP receptor activity |
IEA | -- |
STX10 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for STX10:
|
Pathways & Interactions
for STX10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Botulinum neurotoxicity | | | 2 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics | | | 3 | Disease | | | 4 | Transmission across Chemical Synapses | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for STX10
1  PharmGKB Pathway for STX10
1 
Kegg Pathway (Kegg details for STX10):
STX10 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STX10
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/15 Interacting proteins for STX10 (O604993 ENSP000002427704) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
STX10 for ontologies About GeneDecksing
|
Drugs & Compounds
for STX10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STX10
Search CenterWatch for drugs/clinical trials and news about STX10
|
Transcripts
for STX10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STX10 gene (4 alternative transcripts): NM_001271609.1 NM_001271610.1 NM_001271611.1 NM_003765.2 Unigene Cluster for STX10: Syntaxin 10 Hs.43812 [show with all ESTs]Unigene Representative Sequence: BQ05739411 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000591843 ENST00000343587 ENST00000587318 ENST00000242770(uc002mwn.3 uc010xna.2 uc021upq.1)
ENST00000589083 ENST00000587230 ENST00000593126 ENST00000440593(uc002mwo.3)
ENST00000588848 ENST00000591415 ENST00000591197
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX10
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX10 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STX10 (NM_003765) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STX10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX10 |
Additional cDNA sequence: AF035531.1 AY778966.1 BC017237.2 BC095459.1 CR457110.1 13 DOTS entries: DT.443904 DT.91920407 DT.100797063 DT.95249257 DT.100797067 DT.121436630 DT.100700384 DT.100739899 DT.95249241 DT.95249242 DT.95249252 DT.100766915 DT.97778767 24/242 AceView cDNA sequences (see all 242): CD675482 AA514882 CR614578 AA296481 AI264092 BQ938475 BQ938915 BE740471 BM563609 CR622979 AA505976 BM910481 BQ084430 BQ441723 BQ229894 NM_003765 BQ021424 CF126512 BE263180 BU149322 BQ694109 CD364936 BM564336 BF116041
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for STX10 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for STX10
|
Expression
for STX10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STX10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See STX10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STX10
SOURCE GeneReport for Unigene cluster: Hs.43812
UniProtKB/Swiss-Prot: STX10_HUMAN, O60499Tissue specificity: Expressed at high levels in heart, skeletal muscle and pancreas
SABiosciences Custom PCR Arrays for STX10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STX10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat STX10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX10 |
Orthologs
for STX10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for STX10 gene from 6/21 species (see all 21) About this table
Species with no ortholog for STX10
ENSEMBL Gene Tree for STX10 (if available)
TreeFam Gene Tree for STX10 (if available) |
Paralogs
for STX10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STX10 gene
- STX62
1 SIMAP similar gene for STX10 using alignment to 9 protein entries: STX10_HUMAN (see all proteins):STX6
STX10 for paralogs About GeneDecksing
|
Genomic Variants
for STX10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STX10 (13254872 - 13261197 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for STX10: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STX10 |
|
Disorders
/ Diseases
for STX10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STX10 for disorders About GeneDecksing
OMIM gene information: 603765
OMIM disorders: --
1  disease for STX10: About MalaCardsmalaria
Export disorders for STX10 gene to outside databases
|
Publications
for STX10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STX10 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with STX10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Syntaxin 10: a member of the syntaxin family localized to the trans- Golgi network. (PubMed id 9446797)1, 2, 3, 9 Tang B.L.... Hong W. (1998)
- A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells. (PubMed id 18195106)1, 2, 9 Ganley I.G....Pfeffer S.R. (2008)
- Characterization of the human GARP (Golgi associated retrograde protein) complex. (PubMed id 15878329)1, 2, 9 Liewen H.... Stenner-Liewen F. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16. (PubMed id 16154903)1, 9 Wang Y....Tang B.L. (2005)
- Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. (PubMed id 10080545)1, 9 Martin-Martin B.... Mollinedo F. (1999)
- A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
|
External Searches for STX10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STX10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STX10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STX10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STX10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STX10 gene:
Search GeneIP for patents involving STX10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STX10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for STX10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STX10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STX10 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STX10 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STX10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STX10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STX10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STX10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STX10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STX10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STX10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STX10 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STX10 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STX10 |
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