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Aliases for STX10 Gene

Aliases for STX10 Gene

  • Syntaxin 10 2 3
  • SYN10 3 4
  • Syntaxin-10 3
  • Hsyn10 3

External Ids for STX10 Gene

Previous GeneCards Identifiers for STX10 Gene

  • GC19M013587
  • GC19M013100
  • GC19M013116
  • GC19M013115
  • GC19M013254
  • GC19M012827

Summaries for STX10 Gene

Entrez Gene Summary for STX10 Gene

  • This gene belongs to the syntaxin family and encodes a soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE). The encoded protein is involved in docking and fusion events at the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

GeneCards Summary for STX10 Gene

STX10 (Syntaxin 10) is a Protein Coding gene. Among its related pathways are Disease and Transmission across Chemical Synapses. GO annotations related to this gene include SNAP receptor activity. An important paralog of this gene is STX6.

UniProtKB/Swiss-Prot for STX10 Gene

  • SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

Gene Wiki entry for STX10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX10 Gene

Genomics for STX10 Gene

Regulatory Elements for STX10 Gene

Genomic Location for STX10 Gene

Start:
13,144,058 bp from pter
End:
13,150,383 bp from pter
Size:
6,326 bases
Orientation:
Minus strand

Genomic View for STX10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STX10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX10 Gene

Proteins for STX10 Gene

  • Protein details for STX10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60499-STX10_HUMAN
    Recommended name:
    Syntaxin-10
    Protein Accession:
    O60499
    Secondary Accessions:
    • A6NC41
    • Q6IAP4
    • Q96AE8

    Protein attributes for STX10 Gene

    Size:
    249 amino acids
    Molecular mass:
    28114 Da
    Quaternary structure:
    • Interacts with VPS52.

    Three dimensional structures from OCA and Proteopedia for STX10 Gene

    Alternative splice isoforms for STX10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STX10 Gene

Proteomics data for STX10 Gene at MOPED

Post-translational modifications for STX10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STX10 Gene

Domains for STX10 Gene

Protein Domains for STX10 Gene

Suggested Antigen Peptide Sequences for STX10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60499

UniProtKB/Swiss-Prot:

STX10_HUMAN :
  • O60499
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX10: view

No data available for Gene Families for STX10 Gene

Function for STX10 Gene

Molecular function for STX10 Gene

UniProtKB/Swiss-Prot Function: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

Gene Ontology (GO) - Molecular Function for STX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 15878329
GO:0019905 syntaxin binding IPI 16154903
genes like me logo Genes that share ontologies with STX10: view

Phenotypes for STX10 Gene

GenomeRNAi human phenotypes for STX10:
genes like me logo Genes that share phenotypes with STX10: view

miRNA for STX10 Gene

miRTarBase miRNAs that target STX10

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for STX10 Gene

Localization for STX10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX10 Gene

Golgi apparatus membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STX10 Gene COMPARTMENTS Subcellular localization image for STX10 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
endosome 2
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005802 trans-Golgi network IDA 16154903
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
GO:0031201 SNARE complex IBA --
genes like me logo Genes that share ontologies with STX10: view

Pathways for STX10 Gene

genes like me logo Genes that share pathways with STX10: view

Pathways by source for STX10 Gene

2 Reactome pathways for STX10 Gene
1 KEGG pathway for STX10 Gene

Gene Ontology (GO) - Biological Process for STX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006906 vesicle fusion IBA --
GO:0016192 vesicle-mediated transport --
GO:0032880 regulation of protein localization IMP 16154903
GO:0034498 NOT early endosome to Golgi transport IDA 16154903
genes like me logo Genes that share ontologies with STX10: view

Transcripts for STX10 Gene

Unigene Clusters for STX10 Gene

Syntaxin 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STX10 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5: -
SP6:

Relevant External Links for STX10 Gene

GeneLoc Exon Structure for
STX10
ECgene alternative splicing isoforms for
STX10

Expression for STX10 Gene

mRNA expression in normal human tissues for STX10 Gene

mRNA differential expression in normal tissues according to GTEx for STX10 Gene

This gene is overexpressed in Whole Blood (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX10 Gene

SOURCE GeneReport for Unigene cluster for STX10 Gene Hs.43812

mRNA Expression by UniProt/SwissProt for STX10 Gene

O60499-STX10_HUMAN
Tissue specificity: Expressed at high levels in heart, skeletal muscle and pancreas
genes like me logo Genes that share expressions with STX10: view

Orthologs for STX10 Gene

This gene was present in the common ancestor of animals.

Orthologs for STX10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STX10 35
  • 94.78 (n)
  • 93.57 (a)
STX10 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STX10 35
  • 88.62 (n)
  • 91.16 (a)
STX10 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STX10 35
  • 92.37 (n)
  • 91.97 (a)
STX10 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STX10 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stx10 35
  • 69.86 (n)
  • 65.65 (a)
zebrafish
(Danio rerio)
Actinopterygii CR847925.1 36
  • 63 (a)
OneToOne
LOC100151249 35
  • 64.94 (n)
  • 63.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syx6 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea syx-6 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7279 36
  • 44 (a)
OneToMany
Species with no ortholog for STX10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX10 Gene

ENSEMBL:
Gene Tree for STX10 (if available)
TreeFam:
Gene Tree for STX10 (if available)

Paralogs for STX10 Gene

Paralogs for STX10 Gene

Selected SIMAP similar genes for STX10 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with STX10: view

Variants for STX10 Gene

Sequence variations from dbSNP and Humsavar for STX10 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs11775 -- 13,144,061(+) AATAC(A/C/G)TATAA utr-variant-3-prime
rs2304095 -- 13,144,722(-) CGGCC(A/G)CCCTG intron-variant
rs4926127 -- 13,143,660(+) gctcc(C/T)gcctg downstream-variant-500B
rs4926137 -- 13,148,204(+) cccta(C/T)taaaa intron-variant
rs4926225 -- 13,143,806(+) aatcc(A/C)agcta downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for STX10 Gene

Variant ID Type Subtype PubMed ID
nsv911082 CNV Loss 21882294
nsv911087 CNV Loss 21882294
dgv3737n71 CNV Loss 21882294

Relevant External Links for STX10 Gene

HapMap Linkage Disequilibrium report
STX10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX10 Gene

Disorders for STX10 Gene

No disorders were found for STX10 Gene.

No data available for UniProtKB/Swiss-Prot for STX10 Gene

Publications for STX10 Gene

  1. Syntaxin 10: a member of the syntaxin family localized to the trans- Golgi network. (PMID: 9446797) Tang B.L. … Hong W. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  2. Characterization of the human GARP (Golgi associated retrograde protein) complex. (PMID: 15878329) Liewen H. … Stenner-Liewen F. (Exp. Cell Res. 2005) 3 4 23
  3. A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells. (PMID: 18195106) Ganley I.G. … Pfeffer S.R. (J. Cell Biol. 2008) 3 4 23
  4. Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16. (PMID: 16154903) Wang Y. … Tang B.L. (Mol. Membr. Biol. 2005) 3 23
  5. Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. (PMID: 10080545) Martin-Martin B. … Mollinedo F. (J. Leukoc. Biol. 1999) 3 23

Products for STX10 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate STX10
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for STX10
    • Block miRNA regulation of STX10 using miScript Target Protectors
    • Addgene plasmids for STX10

    Sources for STX10 Gene

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