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Aliases for STUM Gene

Aliases for STUM Gene

  • Stum, Mechanosensory Transduction Mediator Homolog 2 3 5
  • C1orf95 3 4
  • Chromosome 1 Open Reading Frame 95 2
  • Stumble Homolog (Drosophila) 2
  • Protein Stum Homolog 3
  • Stumble Homolog 3

External Ids for STUM Gene

Previous HGNC Symbols for STUM Gene

  • C1orf95

Summaries for STUM Gene

GeneCards Summary for STUM Gene

STUM (Stum, Mechanosensory Transduction Mediator Homolog) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STUM Gene

Genomics for STUM Gene

Regulatory Elements for STUM Gene

Enhancers for STUM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G226601 1 Ensembl ENCODE 47.9 +55.5 55546 3.8 PKNOX1 KLF1 TAL1 TEAD4 ZIC2 ZFHX2 GLIS2 ZNF316 EGR1 NFE2 STUM ITPKB ITPKB-AS1 COQ8A GC01P226605 GC01P226597
GH01G226813 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +267.2 267181 4.0 PKNOX1 SIN3A FEZF1 BRCA1 GLIS2 GATA2 ZNF143 FOS DEK TSHZ1 PSEN2 ITPKB STUM COQ8A GC01P226812
GH01G226402 1.5 FANTOM5 ENCODE 10.1 -142.6 -142623 6.6 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 PARP1 STUM MIXL1 PSEN2 LOC101060016
GH01G226588 0.6 ENCODE 22.8 +40.7 40703 1.3 NRF1 REST ZNF555 ZFHX2 ZNF585B EGR2 EZH2 ZBTB20 STUM GC01P226597 GC01M226537
GH01G226651 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6 +111.7 111709 16.5 HDGF PKNOX1 WRNIP1 SIN3A FEZF1 YBX1 ZNF766 ZNF143 FOS KLF13 ITPKB STUM PSEN2 ITPKB-AS1 GC01P226605
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STUM on UCSC Golden Path with GeneCards custom track

Promoters for STUM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000021110 552 401 ARNT ZNF76 KLF17 GLI4 GLIS2 SP3 ZNF781 ZNF610 KLF16 GLIS1

Genomic Location for STUM Gene

Chromosome:
1
Start:
226,548,248 bp from pter
End:
226,609,214 bp from pter
Size:
60,967 bases
Orientation:
Plus strand

Genomic View for STUM Gene

Genes around STUM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STUM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STUM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STUM Gene

Proteins for STUM Gene

  • Protein details for STUM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69YW2-STUM_HUMAN
    Recommended name:
    Protein stum homolog
    Protein Accession:
    Q69YW2
    Secondary Accessions:
    • A6NGL2

    Protein attributes for STUM Gene

    Size:
    141 amino acids
    Molecular mass:
    15007 Da
    Quaternary structure:
    No Data Available

neXtProt entry for STUM Gene

Post-translational modifications for STUM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STUM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STUM Gene

Domains & Families for STUM Gene

Protein Domains for STUM Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STUM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q69YW2

UniProtKB/Swiss-Prot:

STUM_HUMAN :
  • Belongs to the SPEC3 family. Stum subfamily.
Family:
  • Belongs to the SPEC3 family. Stum subfamily.
genes like me logo Genes that share domains with STUM: view

No data available for Gene Families for STUM Gene

Function for STUM Gene

genes like me logo Genes that share phenotypes with STUM: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STUM Gene

Localization for STUM Gene

Subcellular locations from UniProtKB/Swiss-Prot for STUM Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STUM gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for STUM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STUM: view

Pathways & Interactions for STUM Gene

No Data Available

Interacting Proteins for STUM Gene

Gene Ontology (GO) - Biological Process for STUM Gene

None

No data available for Pathways by source and SIGNOR curated interactions for STUM Gene

Transcripts for STUM Gene

mRNA/cDNA for STUM Gene

(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for STUM Gene

No ASD Table

Relevant External Links for STUM Gene

GeneLoc Exon Structure for
STUM
ECgene alternative splicing isoforms for
STUM

Expression for STUM Gene

NURSA nuclear receptor signaling pathways regulating expression of STUM Gene:

STUM

Evidence on tissue expression from TISSUES for STUM Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with STUM: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STUM Gene

Orthologs for STUM Gene

This gene was present in the common ancestor of chordates.

Orthologs for STUM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf95 35
  • 100 (a)
OneToOne
C1H1orf95 34
  • 99.76 (n)
cow
(Bos Taurus)
Mammalia MGC151592 35
  • 99 (a)
OneToOne
C16H1orf95 34
  • 95 (n)
dog
(Canis familiaris)
Mammalia C1orf95 35
  • 95 (a)
OneToOne
C7H1orf95 34
  • 93.29 (n)
mouse
(Mus musculus)
Mammalia 6330403A02Rik 34 35
  • 91.49 (n)
Stum 16
rat
(Rattus norvegicus)
Mammalia LOC689499 34
  • 90.78 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf95 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1ORF95 34 35
  • 84.31 (n)
lizard
(Anolis carolinensis)
Reptilia C1orf95 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490899 34
  • 83.65 (n)
zebrafish
(Danio rerio)
Actinopterygii C20H1orf95 35
  • 83 (a)
OneToOne
si:dkeyp-59a8.4 34
  • 81.41 (n)
Species where no ortholog for STUM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STUM Gene

ENSEMBL:
Gene Tree for STUM (if available)
TreeFam:
Gene Tree for STUM (if available)

Paralogs for STUM Gene

No data available for Paralogs for STUM Gene

Variants for STUM Gene

Sequence variations from dbSNP and Humsavar for STUM Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000063416 -- 226,595,862(+) CATCC(C/T)TGAGG intron-variant
rs1000175762 -- 226,599,578(+) TTTTC(A/G)CATGG intron-variant
rs1000215311 -- 226,559,498(+) TGAAC(A/G)CACCG intron-variant
rs1000247531 -- 226,600,033(+) GGATG(A/G)GGCAC intron-variant
rs1000327298 -- 226,553,732(+) TGCAT(A/G)ATATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STUM Gene

Variant ID Type Subtype PubMed ID
nsv470779 CNV loss 18288195
nsv4755 CNV insertion 18451855
nsv477811 CNV novel sequence insertion 20440878
nsv522446 CNV loss 19592680
nsv832781 CNV gain 17160897

Variation tolerance for STUM Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STUM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STUM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STUM Gene

Disorders for STUM Gene

Relevant External Links for STUM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STUM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STUM

No disorders were found for STUM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STUM Gene

Publications for STUM Gene

  1. The stum gene is essential for mechanical sensing in proprioceptive neurons. (PMID: 24626929) Desai B.S. … Cook B. (Science 2014) 2 3 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3 64

Products for STUM Gene

Sources for STUM Gene

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