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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STUB1 Gene

protein-coding   GIFtS: 64
GCID: GC16P000823

STIP1 Homology And U-Box Containing Protein 1, E3 Ubiquitin...

(Previous name: STIP1 homology and U-box containing protein 1)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
STIP1 Homology And U-Box Containing Protein 1, E3 Ubiquitin Protein
Ligase1 2
     NY-CO-72
CHIP2 3 5     SDCCAG72
Antigen NY-CO-72 3     UBOX12
Carboxy Terminus Of Hsp70-Interacting Protein2 3     E3 Ubiquitin-Protein Ligase CHIP2
CLL-Associated Antigen KW-82 3     Heat Shock Protein A Binding Protein 2 (C-Terminal)2
STIP1 Homology And U Box-Containing Protein 12 3     Serologically Defined Colon Cancer Antigen 72
STIP1 Homology And U-Box Containing Protein 11     EC 6.3.2.-3
HSPABP22     

External Ids:    HGNC: 114271   Entrez Gene: 102732   Ensembl: ENSG000001032667   OMIM: 6072075   UniProtKB: Q9UNE73   

Export aliases for STUB1 gene to outside databases

Previous GC identifers: GC16P000749 GC16P000670 GC16P000731 GC16P000652 GC16P000734 GC16P000735 GC16P000736 GC16P000769


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STUB1 Gene:
STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a
broad range of chaperone protein substrates for degradation (Min et al., 2008 (PubMed 18411298)).(supplied by
OMIM, Jul 2009)

GeneCards Summary for STUB1 Gene: 
STUB1 (STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with STUB1 include tauopathy, and lafora disease, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. GO annotations related to this gene include enzyme binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: CHIP_HUMAN, Q9UNE7
Function: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal
degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the
length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates
NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70,
Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8
degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81',
thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the
HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates
polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through
proteasomal degradation

Gene Wiki entry for STUB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STUB1 gene promoter:
         Sp1   p53   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): STUB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for STUB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STUB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

STUB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STUB1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000823:  view genomic region     (about GC identifiers)

Start:
730,115 bp from pter      End:
732,799 bp from pter
Size:
2,685 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CHIP_HUMAN, Q9UNE7 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase CHIP  
Size: 303 amino acids; 34856 Da
Subunit: Homodimer (By similarity). Interacts with BAG2, and with the E2 ubiquitin conjugating enzymes UBE2D1,
UBE2D2 and UBE2D3. Interacts with the C-terminal domains of HSPA8 and HSPA1A. Detected in a ternary complex
containing STUB1, HSPA1A and HSPBP1. Interacts with MKKS. Interacts with DYX1C1 and POLB. Interacts (via TPR
repeats) with HSP90AA1. Interacts (when monoubiquitinated) with ATXN3. Interacts with UBE2W (By similarity).
Interacts (via the U-box domain) with the UBE2V2-UBE2N heterodimer; the complex has a specific 'Lys-63'-linked
polyubiquitination activity. Interacts with DNAJB6
Subcellular location: Cytoplasm
Miscellaneous: Antibodies against STUB1 are found in patients with chronic lymphocytic leukemia (CLL) and in
colorectal cancer patients
Secondary accessions: A2IDB9 O60526 Q969U2 Q9HBT1
Alternative splicing: 2 isoforms:  Q9UNE7-1   Q9UNE7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STUB1: NX_Q9UNE7

Explore proteomics data for STUB1 at MOPED 

Post-translational modifications:

  • UniProtKB: Monoubiquitinated at Lys-2 following cell stress by UBE2W, promoting the interaction with ATXN3 (By similarity).
    Auto-ubiquitinated; mediated by UBE2D1 and UBE2D2
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UNE7

  • STUB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STUB1 Protein Expression
    REFSEQ proteins: NP_005852.2  
    ENSEMBL proteins: 
     ENSP00000457228   ENSP00000219548   ENSP00000456591   ENSP00000456875   ENSP00000457583  
     ENSP00000457090  
    Reactome Protein details: Q9UNE7
    Human Recombinant Protein Products for STUB1: 
    EMD Millipore Purified and/or Recombinant STUB1 Protein
    R&D Systems Recombinant & Natural Proteins for STUB1 (CHIP/STUB1)
    Enzo Life Sciences proteins for STUB1
    OriGene Purified Protein for STUB1
    OriGene Protein Over-expression Lysate for STUB1
    OriGene MassSpec for STUB1 
    OriGene Custom Protein Services for STUB1
    GenScript Custom Purified and Recombinant Proteins Services for STUB1
    Novus Biologicals STUB1 Proteins
    Novus Biologicals STUB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for STUB1
    Cloud-Clone Corp. Proteins for STUB1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA16307917
    GO:0005737cytoplasm IDA10330192
    GO:0005829cytosol TAS--
    GO:0031371ubiquitin conjugating enzyme complex TAS16307917
    GO:0042405nuclear inclusion body IDA16831871

    STUB1 for ontologies           About GeneDecksing



    STUB1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of STUB1
    R&D Systems Antibodies for STUB1 (CHIP/STUB1)
    Cell Signaling Technology (CST) Antibodies for STUB1  (CHIP)
    OriGene Antibodies for STUB1
    OriGene Custom Antibody Services for STUB1
    GenScript Superior Antibodies for STUB1
    Novus Biologicals STUB1 Antibodies
    Abcam antibodies for STUB1
    Cloud-Clone Corp. Antibodies for STUB1 
    ThermoFisher Antibody for STUB1
    LSBio Antibodies in human, mouse, rat for STUB1 

    Assay Products for STUB1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STUB1
    R&D Systems Ubiquitin Proteasome Pathway (UPP) Assay Kits & Reagents for STUB1 (CHIP/STUB1)
    GenScript Custom Assay Services for STUB1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STUB1 
    Cloud-Clone Corp. CLIAs for STUB1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBOX: U-box domain containing
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR001440 TPR-1
     IPR011990 TPR-like_helical
     IPR003613 Ubox_domain
     IPR013083 Znf_RING/FYVE/PHD
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9UNE7

    ProtoNet protein and cluster: Q9UNE7

    1 Blocks protein domain: IPB003613 Zn-finger

    UniProtKB/Swiss-Prot: CHIP_HUMAN, Q9UNE7
    Domain: The TPR domain is essential for ubiquitination mediated by UBE2D1
    Similarity: Contains 3 TPR repeats
    Similarity: Contains 1 U-box domain


    STUB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHIP_HUMAN, Q9UNE7
    Function: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal
    degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the
    length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates
    NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70,
    Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8
    degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81',
    thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the
    HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates
    polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through
    proteasomal degradation

         Genatlas biochemistry entry for STUB1:
    yeast STIP1 homolog and U-box containing protein 1,highly expressed in adult striated muscle,binding and
    interacting with the C terminus of heat shock protein HSP70,also interacting with HSP70

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS16307917
    GO:0005515protein binding IPI11146632
    GO:0019899enzyme binding IPI16280320
    GO:0019900kinase binding IPI17512523
    GO:0030544Hsp70 protein binding IDA10330192
         
    STUB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for STUB1:
     Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Stub1):
     behavior/neurological  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  nervous system 

    STUB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for STUB1: Stub1tm1Lex Stub1tm1Atak Stub1tm1Cpat

       inGenious Targeting Laboratory - Custom generated mouse model solutions for STUB1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STUB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STUB1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STUB1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STUB1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate STUB1:
    hsa-miR-1178 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidSTUB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STUB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STUB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STUB1
    Sirion Biotech Customized adenovirus for overexpression of STUB1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for STUB1 (see all 7)
    OriGene ORF clones in mouse, rat for STUB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STUB1 (NM_005861)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STUB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STUB1
    Sirion Biotech Customized lentivirus for stable overexpression of STUB1 
                         Customized lentivirus expression plasmids for stable overexpression of STUB1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for STUB1
    Search LifeMap BioReagents cell lines for STUB1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STUB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STUB1 About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3TGF-beta receptor signaling activates SMADs
    Downregulation of TGF-beta receptor signaling0.90
    TGF-beta receptor signaling activates SMADs0.90
    4Regulation of degradation of wt-CFTR
    Regulation of degradation of deltaF508 CFTR in CF0.59
    Regulation of degradation of wt-CFTR0.59
    5Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for STUB1
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for STUB1
        SMAD Signaling Network
    Ubiquitin-Proteasome Dependent Proteolysis
    eNOS Signaling
    Parkinson's Disease Pathway

    1 Cell Signaling Technology (CST) Pathway for STUB1
        Protein Stability

    4 GeneGo (Thomson Reuters) Pathways for STUB1
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    Proteolysis Putative ubiquitin pathway
    Regulation of degradation of wt-CFTR

    3 BioSystems Pathways for STUB1
        Parkin-Ubiquitin Proteasomal System pathway
    Androgen receptor signaling pathway
    Alpha-synuclein signaling

    5/9        Reactome Pathways for STUB1 (see all 9)
        TGF-beta receptor signaling activates SMADs
    Adaptive Immune System
    Signaling by ERBB2
    Signaling by TGF-beta Receptor Complex
    Antigen processing: Ubiquitination & Proteasome degradation


    2         Kegg Pathways  (Kegg details for STUB1):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: CHIP_HUMAN, Q9UNE7
    Pathway: Protein modification; protein ubiquitination


    STUB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STUB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/201 Interacting proteins for STUB1 (Q9UNE71, 2, 3 ENSP000002195484) via UniProtKB, MINT, STRING, and/or I2D (see all 201)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081071, 2, 3EBI-357085,EBI-629985 MINT-7903424 I2D: score=4 
    ENSG00000215328P081071, 2, 3EBI-357085,EBI-629985 MINT-7903424 I2D: score=4 
    ENSG00000224501P081071, 2, 3EBI-357085,EBI-629985 MINT-7903424 I2D: score=4 
    ENSG00000231555P081071, 2, 3EBI-357085,EBI-629985 MINT-7903424 I2D: score=4 
    ENSG00000232804P081071, 2, 3EBI-357085,EBI-629985 MINT-7903424 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IMP19713937
    GO:0006281DNA repair IEA--
    GO:0006511ubiquitin-dependent protein catabolic process IMP19713937
    GO:0006515misfolded or incompletely synthesized protein catabolic process IDA16831871
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--

    STUB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STUB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STUB1 (CHIP)

    4 HMDB Compounds for STUB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    5 Novoseek inferred chemical compound relationships for STUB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 77.1 7 16037132 (3), 12962497 (1), 15046863 (1), 12574167 (1)
    glutamine 36 3 17442270 (2), 17317785 (1)
    estrogen 19 3 16037132 (2)
    testosterone 15.5 2 16725394 (1), 15107424 (1)
    tyrosine 0 1 18655187 (1)

    Search CenterWatch for drugs/clinical trials and news about STUB1 / CHIP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STUB1 gene: 
    NM_005861.2  

    Unigene Cluster for STUB1:

    STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
    Hs.592081  [show with all ESTs]
    Unigene Representative Sequence: NM_005861
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565677(uc002cit.3 uc002ciu.3) ENST00000219548 ENST00000569248
    ENST00000567173 ENST00000563505 ENST00000567790 ENST00000564370 ENST00000566181
    ENST00000566408 ENST00000564316

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate STUB1:
    hsa-miR-1178 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidSTUB1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: STUB1 (NM_005861)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STUB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STUB1
    Sirion Biotech Customized lentivirus for stable overexpression of STUB1 
                         Customized lentivirus expression plasmids for stable overexpression of STUB1 
    Primer
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    OriGene qPCR primer pairs and template standards for STUB1
    OriGene qSTAR qPCR primer pairs in human, mouse for STUB1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STUB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STUB1

    Additional mRNA sequence: 

    AF039689.1 AF129085.1 AF217968.1 AF432221.1 BC007545.1 BC017178.1 BC022788.1 BC063617.1 

    23 DOTS entries:

    DT.100723261  DT.447259  DT.100654784  DT.92453006  DT.92452998  DT.100637940  DT.100775901  DT.120670800 
    DT.100654785  DT.219419  DT.100842616  DT.120670723  DT.40264699  DT.92452993  DT.95084511  DT.120670769 
    DT.100703078  DT.92452992  DT.95084580  DT.91788875  DT.92389737  DT.95084530  DT.95091807 

    24/419 AceView cDNA sequences (see all 419):

    BC007545 AI313142 BM825037 T35464 BQ637784 CR624881 BM840970 CB132540 
    BF316020 CD676029 BQ673734 BM557673 BU166977 BF725102 BI763503 AI265896 
    CA416969 BU630132 BU849146 BG334184 BF342208 CA306234 CD672699 CA416132 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for STUB1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for STUB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STUB1 expression in normal human tissues (normalized intensities)      STUB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACGAGCTTT
    STUB1 Expression
    About this image


    STUB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Epithelium
             oral mucosa ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             lung ; pneumocytes   

    See STUB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STUB1

    SOURCE GeneReport for Unigene cluster: Hs.592081

    UniProtKB/Swiss-Prot: CHIP_HUMAN, Q9UNE7
    Tissue specificity: Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney,
    liver and lung

        SABiosciences Expression via Pathway-Focused PCR Arrays including STUB1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STUB1 gene from 10/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stub11 , 5 STIP1 homology and U-Box containing protein 11, 5 88.89(n)1
    97.69(a)1
      17 (12.93 cM)5
    564241  NM_019719.31  NP_062693.11 
     258306365 
    chicken
    (Gallus gallus)
    Aves STUB11 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase less 83.28(n)
    87.79(a)
      426918  NM_001031406.1  NP_001026577.1 
    lizard
    (Anolis carolinensis)
    Reptilia STUB16
    Uncharacterized protein
    79(a)
    1 ↔ 1
    GL344104.1(24101-42690)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.37522 Xenopus laevis transcribed sequence with weak similarity to protein refNP_491781.1 (C.elegans) T09B4.10.p [Caenorhabditis elegans] less 77.68(n)    BX849641.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc22f042 wufc22f04 80.03(n)   324243  BC051775.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CHIP1 , 3 CG5203-PA1 57(a)3
    59.49(n)1
    58.39(a)1
      31E23
    344331  NM_058093.31  NP_477441.11 
    worm
    (Caenorhabditis elegans)
    Secernentea chn-11 Protein CHN-1 47.55(n)
    43.8(a)
      172303  NM_059380.5  NP_491781.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SGT26
    Glutamine-rich cytoplasmic protein that serves as ...
    10(a)
    1 → many
    XV(338938-339978)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CHIP1 E3 ubiquitin-protein ligase CHIP 44.07(n)
    35.23(a)
      819925  NM_111616.2  NP_566305.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01133001 hypothetical protein 58.9(n)
    60.27(a)
      4344499  NM_001067374.1  NP_001060839.2 


    ENSEMBL Gene Tree for STUB1 (if available)
    TreeFam Gene Tree for STUB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STUB1 gene

    STUB1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STUB1
    PGOHUM00000241028


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/39 SNPs in STUB1 are shown (see all 39)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs286489871,2
    C--728847(+) ACGGGC/TCACCC 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs617407331,2
    C,F--728922(+) CAGGTA/GCAGCA 1 -- us2k12Minor allele frequency- G:0.02NS WA 188
    rs1423437811,2
    --728957(+) GGGCCA/GGCCAG 1 -- us2k10--------
    rs1813266211,2
    --728981(+) CCACCA/GCCTCA 1 -- us2k10--------
    rs1446308401,2
    --729055(+) AAGCAA/GCCAGA 1 -- us2k10--------
    rs1868483461,2
    --729116(+) GCCCTA/GTGGTT 1 -- us2k10--------
    rs734874931,2
    C,F--729295(+) GGCGGT/ACGAAC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs747923091,2
    --729415(+) AGGGAC/GGCCCC 1 -- us2k10--------
    rs779568821,2
    C,F--729444(+) CGCCCC/AGCCGA 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs802754481,2
    C,F--729456(+) GCCACG/TCCCCA 1 -- us2k11Minor allele frequency- T:0.19WA 118

    HapMap Linkage Disequilibrium report for STUB1 (730115 - 732799 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/29 variations for STUB1 (see all 29):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    dgv2475n71CNV Loss21882294
    nsv904707CNV Loss21882294
    dgv2487n71CNV Loss21882294
    nsv904796CNV Loss21882294
    dgv2492n71CNV Loss21882294
    nsv904797CNV Loss21882294
    dgv2493n71CNV Loss21882294
    nsv904759CNV Loss21882294
    dgv2479n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing STUB1
    DNA2.0 Custom Variant and Variant Library Synthesis for STUB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607207    OMIM disorders: --

    20/27 diseases for STUB1 (see all 27):    About MalaCards
    tauopathy    lafora disease    dyslexia    colon cancer
    limb-girdle muscular dystrophy    multiple endocrine neoplasia    parkinson's disease    chronic myeloid leukemia
    chronic lymphocytic leukemia    muscular dystrophy    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    cystic fibrosis    lateral sclerosis    amyotrophic lateral sclerosis    cytochrome p450
    myeloid leukemia    hypoxia    schizophrenia    leukemia


    STUB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for STUB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tauopathies 51.3 2 15447663 (1), 16111477 (1)
    neurodegenerative diseases 46 3 17442270 (1), 18583953 (1)
    shock 38.9 6 10330192 (1), 16720573 (1), 17442270 (1)
    parkinson disease 18.1 1 17317785 (1)
    alzheimers disease 1.56 1 17317785 (1)


    Export disorders for STUB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STUB1 gene, integrated from 9 sources (see all 250):
    (articles sorted by number of sources associating them with STUB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. (PubMed id 10330192)1, 2, 3, 9 Ballinger C.A....Patterson C. (1999)
    2. Characterization of human colon cancer antigens recognized by autologous antibodies. (PubMed id 9610721)1, 2, 3 Scanlan M.J....Old L.J. (1998)
    3. Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase. (PubMed id 15466472)1, 2, 9 Peng H.M....Osawa Y. (2004)
    4. Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. (PubMed id 16307917)1, 2, 9 Zhang M....Pearl L.H. (2005)
    5. MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination. (PubMed id 18094050)1, 2, 9 Hirayama S.... Nagata K. (2008)
    6. Ubiquitin ligase ARF-BP1/Mule modulates base excision repair. (PubMed id 19713937)1, 2 Parsons J.L....Dianov G.L. (2009)
    7. CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. (PubMed id 19103148)1, 2 Pabarcus M.K....Correia M.A. (2009)
    8. Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology. (PubMed id 18042044)1, 2 Windheim M....Cohen P. (2008)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    10. Regulation of the cytoplasmic quality control protein degradation pathway by BAG2. (PubMed id 16169850)1, 2 Dai Q.... Patterson C. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10273 HGNC: 11427 AceView: STUB1 Ensembl:ENSG00000103266 euGenes: HUgn10273
    ECgene: STUB1 Kegg: 10273 H-InvDB: STUB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STUB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STUB1 gene:
    Search GeneIP for patents involving STUB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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