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STUB1 Gene

protein-coding   GIFtS: 65
GCID: GC16P000848

STIP1 Homology And U-Box Containing Protein 1, E3 Ubiquitin...

(Previous name: STIP1 homology and U-box containing protein 1)
  See STUB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
STIP1 Homology And U-Box Containing Protein 1, E3 Ubiquitin Protein
Ligase1 2
     NY-CO-72
CHIP2 3 5     SDCCAG72
Antigen NY-CO-72 3     UBOX12
Carboxy Terminus Of Hsp70-Interacting Protein2 3     E3 Ubiquitin-Protein Ligase CHIP2
CLL-Associated Antigen KW-82 3     Heat Shock Protein A Binding Protein 2 (C-Terminal)2
STIP1 Homology And U Box-Containing Protein 12 3     Serologically Defined Colon Cancer Antigen 72
STIP1 Homology And U-Box Containing Protein 11     EC 6.3.2.-3
HSPABP22     

External Ids:    HGNC: 114271   Entrez Gene: 102732   Ensembl: ENSG000001032667   OMIM: 6072075   UniProtKB: Q9UNE73   

Export aliases for STUB1 gene to outside databases

Previous GC identifers: GC16P000749 GC16P000670 GC16P000731 GC16P000652 GC16P000734 GC16P000735 GC16P000736 GC16P000769 GC16P000823


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STUB1 Gene:
STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a
broad range of chaperone protein substrates for degradation (Min et al., 2008 (PubMed 18411298)).(supplied by
OMIM, Jul 2009)

GeneCards Summary for STUB1 Gene:
STUB1 (STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with STUB1 include spinocerebellar ataxia, autosomal recessive 16, and cerebellar ataxia and hypogonadotropic hypogonadism. GO annotations related to this gene include enzyme binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: CHIP_HUMAN, Q9UNE7
Function: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal
degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the
length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates
NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70,
Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8
degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81',
thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the
HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates
polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through
proteasomal degradation

Gene Wiki entry for STUB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the STUB1 gene promoter:
         Sp1   p53   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): STUB1 promoter sequence
   Search Chromatin IP Primers for STUB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STUB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

STUB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STUB1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000848:  view genomic region     (about GC identifiers)

Start:
730,115 bp from pter      End:
732,870 bp from pter
Size:
2,756 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CHIP_HUMAN, Q9UNE7 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase CHIP  
Size: 303 amino acids; 34856 Da
Subunit: Homodimer (By similarity). Interacts with BAG2, and with the E2 ubiquitin conjugating enzymes UBE2D1,
UBE2D2 and UBE2D3. Interacts with the C-terminal domains of HSPA8 and HSPA1A. Detected in a ternary complex
containing STUB1, HSPA1A and HSPBP1. Interacts with MKKS. Interacts with DYX1C1 and POLB. Interacts (via TPR
repeats) with HSP90AA1. Interacts (when monoubiquitinated) with ATXN3. Interacts with UBE2W (By similarity).
Interacts (via the U-box domain) with the UBE2V2-UBE2N heterodimer; the complex has a specific 'Lys-63'-linked
polyubiquitination activity. Interacts with DNAJB6
Miscellaneous: Antibodies against STUB1 are found in patients with chronic lymphocytic leukemia (CLL) and in
colorectal cancer patients
Secondary accessions: A2IDB9 O60526 Q969U2 Q9HBT1
Alternative splicing: 2 isoforms:  Q9UNE7-1   Q9UNE7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STUB1: NX_Q9UNE7

Explore proteomics data for STUB1 at MOPED

Post-translational modifications: 

  • Monoubiquitinated at Lys-2 following cell stress by UBE2W, promoting the interaction with ATXN3 (By similarity).
    Auto-ubiquitinated; mediated by UBE2D1 and UBE2D21
  • Ubiquitination2 at Lys2, Lys22, Lys221, Lys255
  • Modification sites at PhosphoSitePlus

  • See STUB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005852.2  
    ENSEMBL proteins: 
     ENSP00000457228   ENSP00000219548   ENSP00000456591   ENSP00000456875   ENSP00000457583  
     ENSP00000457090   ENSP00000476751  
    Reactome Protein details: Q9UNE7

    STUB1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant STUB1 Protein
    R&D Systems Recombinant & Natural Proteins for STUB1 (CHIP/STUB1)
    Enzo Life Sciences proteins for STUB1
    OriGene Purified Proteins for STUB1
    OriGene Protein Over-expression Lysate for STUB1
    OriGene MassSpec for STUB1
    OriGene Custom Protein Services for STUB1
    GenScript Custom Purified and Recombinant Proteins Services for STUB1
    Novus Biologicals STUB1 Proteins
    Novus Biologicals STUB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for STUB1
    Cloud-Clone Corp. Proteins for STUB1

     
    Search eBioscience for Proteins for STUB1 

    STUB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of STUB1
    R&D Systems Antibodies for STUB1 (CHIP/STUB1)
    Cell Signaling Technology (CST) Antibodies for STUB1  (CHIP)
    OriGene Antibodies for STUB1
    OriGene Custom Antibody Services for STUB1
    Novus Biologicals STUB1 Antibodies
    Abcam antibodies for STUB1
    Cloud-Clone Corp. Antibodies for STUB1
    ThermoFisher Antibody for STUB1
    LSBio Antibodies in human, mouse, rat for STUB1

    STUB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STUB1
    R&D Systems Ubiquitin Proteasome Pathway (UPP) Assay Kits & Reagents for STUB1 (CHIP/STUB1)
    GenScript Custom Assay Services for STUB1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STUB1
    Cloud-Clone Corp. CLIAs for STUB1
    Search eBioscience for ELISAs for STUB1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBOX: U-box domain containing
    TTC: Tetratricopeptide (TTC) repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR001440 TPR_1
     IPR011990 TPR-like_helical
     IPR003613 Ubox_domain
     IPR013083 Znf_RING/FYVE/PHD
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9UNE7

    ProtoNet protein and cluster: Q9UNE7

    1 Blocks protein domain: IPB003613 Zn-finger

    UniProtKB/Swiss-Prot: CHIP_HUMAN, Q9UNE7
    Domain: The TPR domain is essential for ubiquitination mediated by UBE2D1
    Similarity: Contains 3 TPR repeats
    Similarity: Contains 1 U-box domain


    Find genes that share domains with STUB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHIP_HUMAN, Q9UNE7
    Function: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal
    degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the
    length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates
    NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70,
    Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8
    degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81',
    thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the
    HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates
    polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through
    proteasomal degradation

         Genatlas biochemistry entry for STUB1:
    yeast STIP1 homolog and U-box containing protein 1,highly expressed in adult striated muscle,binding and
    interacting with the C terminus of heat shock protein HSP70,also interacting with HSP70

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS16307917
    GO:0005515protein binding IPI11146632
    GO:0019899enzyme binding IPI16280320
    GO:0019900kinase binding IPI17512523
    GO:0030544Hsp70 protein binding IDA10330192
         
    Find genes that share ontologies with STUB1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STUB1:
     Increased gamma-H2AX phosphory 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Stub1):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system  reproductive system 

    Find genes that share phenotypes with STUB1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for STUB1: Stub1tm1Lex Stub1tm1Atak Stub1tm1Cpat

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STUB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STUB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STUB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STUB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target STUB1:
    hsa-mir-26b-5p (MIRT029709), hsa-mir-30a-5p (MIRT028574)

    Block miRNA regulation of human, mouse, rat STUB1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate STUB1:
    hsa-miR-1178 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidSTUB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STUB1
    Predesigned siRNA for gene silencing in human, mouse, rat STUB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STUB1

    Clone
    Products:
         
    OriGene clones in human, mouse for STUB1 (see all 7)
    OriGene ORF clones in mouse, rat for STUB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STUB1 (NM_005861)
    Sino Biological Human cDNA Clone for STUB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STUB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STUB1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STUB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for STUB1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STUB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHIP_HUMAN, Q9UNE7: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    cytoskeleton3
    plasma membrane3

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA16275660
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with STUB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STUB1 About   (see all 17)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Loss of Function of SMAD2/3 in Cancer
    Loss of Function of SMAD2/3 in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    4TGF-beta receptor signaling activates SMADs
    Downregulation of TGF-beta receptor signaling0.82
    TGF-beta receptor signaling activates SMADs0.82
    5Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt CFTR0.59
    Regulation of degradation of deltaF508 CFTR in CF0.59


    Find genes that share SuperPaths with STUB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for STUB1
        SMAD Signaling Network
    Ubiquitin-Proteasome Dependent Proteolysis
    eNOS Signaling
    Parkinson's Disease Pathway

    1 Cell Signaling Technology (CST) Pathway for STUB1
        Protein Stability

    4 GeneGo (Thomson Reuters) Pathways for STUB1
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    Proteolysis Putative ubiquitin pathway
    Regulation of degradation of wt-CFTR

    3 BioSystems Pathways for STUB1
        Parkin-Ubiquitin Proteasomal System pathway
    Androgen receptor signaling pathway
    Alpha-synuclein signaling


    3 Reactome Pathways for STUB1
        Signaling by ERBB2
    Antigen processing: Ubiquitination & Proteasome degradation
    Downregulation of TGF-beta receptor signaling


    2 Kegg Pathways  (Kegg details for STUB1):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: CHIP_HUMAN, Q9UNE7
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including STUB1: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for STUB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STUB1 (Q9UNE71, 2, 3 ENSP000002195484) via UniProtKB, MINT, STRING, and/or I2D (see all 218)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K2Q9Y2U51, 2, 3, ENSP000003434634EBI-357085,EBI-357393 MINT-8010534 MINT-8012530 MINT-8010505 MINT-8010493 MINT-8010517 MINT-8010584 MINT-7996786 MINT-8010565 MINT-8010548 MINT-8010453 I2D: score=2 STRING: ENSP00000343463
    ENSG00000212866P081071, 2, 3EBI-357085,EBI-629985 MINT-7903424 I2D: score=4 
    ENSG00000215328P081071, 2, 3EBI-357085,EBI-629985 MINT-7903424 I2D: score=4 
    ENSG00000224501P081071, 2, 3EBI-357085,EBI-629985 MINT-7903424 I2D: score=4 
    ENSG00000231555P081071, 2, 3EBI-357085,EBI-629985 MINT-7903424 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IMP19713937
    GO:0006281DNA repair IEA--
    GO:0006511ubiquitin-dependent protein catabolic process IMP19713937
    GO:0006515misfolded or incompletely synthesized protein catabolic process IDA16831871
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--

    Find genes that share ontologies with STUB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STUB1 (CHIP)

    4 HMDB Compounds for STUB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    5 Novoseek inferred chemical compound relationships for STUB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 77.1 7 16037132 (3), 12962497 (1), 15046863 (1), 12574167 (1)
    glutamine 36 3 17442270 (2), 17317785 (1)
    estrogen 19 3 16037132 (2)
    testosterone 15.5 2 16725394 (1), 15107424 (1)
    tyrosine 0 1 18655187 (1)



    Find genes that share compounds with STUB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STUB1 gene: 
    NM_005861.2  

    Unigene Cluster for STUB1:

    STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
    Hs.592081  [show with all ESTs]
    Unigene Representative Sequence: NM_005861
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565677(uc002cit.3 uc002ciu.3) ENST00000219548 ENST00000569248
    ENST00000567173 ENST00000563505 ENST00000567790 ENST00000564370 ENST00000566181
    ENST00000566408 ENST00000564316 ENST00000565813
    miRNA
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    Block miRNA regulation of human, mouse, rat STUB1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate STUB1:
    hsa-miR-1178 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidSTUB1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for STUB1
    Predesigned siRNA for gene silencing in human, mouse, rat STUB1
    Clone
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    OriGene ORF clones in mouse, rat for STUB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STUB1 (NM_005861)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STUB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STUB1
    Primer
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    OriGene qPCR primer pairs and template standards for STUB1
    OriGene qSTAR qPCR primer pairs in human, mouse for STUB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STUB1
      QuantiTect SYBR Green Assays in human, mouse, rat STUB1
      QuantiFast Probe-based Assays in human, mouse, rat STUB1

    Additional mRNA sequence: 

    AF039689.1 AF129085.1 AF217968.1 AF432221.1 BC007545.1 BC017178.1 BC022788.1 BC063617.1 

    23 DOTS entries:

    DT.100723261  DT.447259  DT.100654784  DT.92453006  DT.92452998  DT.100637940  DT.100775901  DT.120670800 
    DT.100654785  DT.219419  DT.100842616  DT.120670723  DT.40264699  DT.92452993  DT.95084511  DT.120670769 
    DT.100703078  DT.92452992  DT.95084580  DT.91788875  DT.92389737  DT.95084530  DT.95091807 

    Selected AceView cDNA sequences (see all 419):

    BF725102 CF128648 BM557673 AI732281 BE906492 BM478702 CD672699 CR614839 
    BU630978 CA420352 CR603664 CF126431 BM764265 BI824381 BQ673394 R46425 
    CR595251 BC007545 AA377856 AI265896 T35464 C02212 BQ434512 BI763503 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for STUB1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for STUB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    STUB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACGAGCTTT
    STUB1 Expression
    About this image


    STUB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    STUB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STUB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592081

    UniProtKB/Swiss-Prot: CHIP_HUMAN, Q9UNE7
    Tissue specificity: Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney,
    liver and lung

        Pathway & Disease-focused RT2 Profiler PCR Arrays including STUB1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STUB1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stub11 , 5 STIP1 homology and U-Box containing protein 11, 5 88.34(n)1
    97.03(a)1
      17 (12.93 cM)5
    564241  NM_019719.31  NP_062693.11 
     258306365 
    chicken
    (Gallus gallus)
    Aves STUB11 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase less 83.28(n)
    87.79(a)
      426918  NM_001031406.1  NP_001026577.1 
    lizard
    (Anolis carolinensis)
    Reptilia STUB16
    STIP1 homology and U-box containing protein 1, E3 ...
    81(a)
    1 ↔ 1
    GL344104.1(24101-42690)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.37522 Xenopus laevis transcribed sequence with weak similarity to protein refNP_491781.1 (C.elegans) T09B4.10.p [Caenorhabditis elegans] less 77.68(n)    BX849641.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc22f042 wufc22f04 80.03(n)   324243  BC051775.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CHIP1 , 3 CHIP1 57(a)3
    59.21(n)1
    58.12(a)1
      31E23
    344331  NM_058093.41  NP_477441.11 
    worm
    (Caenorhabditis elegans)
    Secernentea chn-11 chn-1 47.66(n)
    44.14(a)
      172303  NM_059380.6  NP_491781.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CHIP1 CHIP 44.07(n)
    35.61(a)
      819925  NM_111616.2  NP_566305.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01133001 Os08g0113300 58.9(n)
    60.27(a)
      4344499  NM_001067374.1  NP_001060839.2 


    ENSEMBL Gene Tree for STUB1 (if available)
    TreeFam Gene Tree for STUB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STUB1 gene

    Find genes that share paralogs with STUB1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for STUB1
    PGOHUM00000241028


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STUB1 (see all 39)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs286489871,2
    C--728847(+) ACGGGC/TCACCC 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs617407331,2
    C,F--728922(+) CAGGTA/GCAGCA 1 -- us2k12Minor allele frequency- G:0.02NS WA 188
    rs1423437811,2
    --728957(+) GGGCCA/GGCCAG 1 -- us2k10--------
    rs1813266211,2
    --728981(+) CCACCA/GCCTCA 1 -- us2k10--------
    rs1446308401,2
    --729055(+) AAGCAA/GCCAGA 1 -- us2k10--------
    rs1868483461,2
    --729116(+) GCCCTA/GTGGTT 1 -- us2k10--------
    rs734874931,2
    C,F--729295(+) GGCGGT/ACGAAC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs747923091,2
    --729415(+) AGGGAC/GGCCCC 1 -- us2k10--------
    rs779568821,2
    C,F--729444(+) CGCCCC/AGCCGA 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs802754481,2
    C,F--729456(+) GCCACG/TCCCCA 1 -- us2k11Minor allele frequency- T:0.19WA 118

    HapMap Linkage Disequilibrium report for STUB1 (730115 - 732870 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STUB1 (see all 29):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    dgv2475n71CNV Loss21882294
    nsv904707CNV Loss21882294
    dgv2487n71CNV Loss21882294
    nsv904796CNV Loss21882294
    dgv2492n71CNV Loss21882294
    nsv904797CNV Loss21882294
    dgv2493n71CNV Loss21882294
    nsv904759CNV Loss21882294
    dgv2479n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STUB1
    DNA2.0 Custom Variant and Variant Library Synthesis for STUB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607207    OMIM disorders: --

    3 diseases for STUB1:    
    About MalaCards
    spinocerebellar ataxia, autosomal recessive 16    cerebellar ataxia and hypogonadotropic hypogonadism    colon cancer


    Find genes that share disorders with STUB1           About GenesLikeMe

    5 Novoseek inferred disease relationships for STUB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tauopathies 51.3 2 15447663 (1), 16111477 (1)
    neurodegenerative diseases 46 3 17442270 (1), 18583953 (1)
    shock 38.9 6 10330192 (1), 16720573 (1), 17442270 (1)
    parkinson disease 18.1 1 17317785 (1)
    alzheimers disease 1.56 1 17317785 (1)


    Export disorders for STUB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STUB1 gene, integrated from 10 sources (see all 264):
    (articles sorted by number of sources associating them with STUB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. (PubMed id 10330192)1, 2, 3, 9 Ballinger C.A....Patterson C. (Mol. Cell. Biol. 1999)
    2. Characterization of human colon cancer antigens recognized by autologous antibodies. (PubMed id 9610721)1, 2, 3 Scanlan M.J.... Old L.J. (Int. J. Cancer 1998)
    3. Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase. (PubMed id 15466472)1, 2, 9 Peng H.M.... Osawa Y. (J. Biol. Chem. 2004)
    4. Chaperoned ubiquitylation -- crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. (PubMed id 16307917)1, 2, 9 Zhang M....Pearl L.H. (Mol. Cell 2005)
    5. MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination. (PubMed id 18094050)1, 2, 9 Hirayama S.... Nagata K. (Mol. Biol. Cell 2008)
    6. Ube2W conjugates ubiquitin to I+-amino groups of protein N-termini. (PubMed id 23560854)1, 2 Tatham M.H....Hay R.T. (Biochem. J. 2013)
    7. Ubiquitin ligase ARF-BP1/Mule modulates base excision repair. (PubMed id 19713937)1, 2 Parsons J.L....Dianov G.L. (EMBO J. 2009)
    8. CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. (PubMed id 19103148)1, 2 Pabarcus M.K....Correia M.A. (Arch. Biochem. Biophys. 2009)
    9. Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology. (PubMed id 18042044)1, 2 Windheim M.... Cohen P. (Biochem. J. 2008)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10273 HGNC: 11427 AceView: STUB1 Ensembl:ENSG00000103266 euGenes: HUgn10273
    ECgene: STUB1 Kegg: 10273 H-InvDB: STUB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STUB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for STUB1 gene:
    Search GeneIP for patents involving STUB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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