STUB1 Gene
protein-coding GIFtS: 64
GCID: GC16P000769
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STIP1 homology and U-box containing protein 1, E3 ubiquitin...(Previous name: STIP1 homology and U-box containing protein 1 )
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Aliases
for STUB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| STIP1 Homology And U-Box Containing Protein 1, E3 Ubiquitin ProteinLigase1 2 | | CLL-Associated Antigen KW-82 3 | | CHIP1 2 3 5 | | STIP1 Homology And U Box-Containing Protein 12 3 | | HSPABP21 2 | | STIP1 Homology And U-Box Containing Protein 11 | | NY-CO-71 2 | | E3 Ubiquitin-Protein Ligase CHIP2 | | SDCCAG71 2 | | Heat Shock Protein A Binding Protein 2 (C-Terminal)2 | | UBOX11 2 | | Serologically Defined Colon Cancer Antigen 72 | | Antigen NY-CO-72 3 | | EC 6.3.2.-3 | | Carboxy Terminus Of Hsp70-Interacting Protein2 3 | | |
Export aliases for STUB1 gene to outside databasesPrevious GC identifers: GC16P000749 GC16P000670 GC16P000731 GC16P000652 GC16P000734 GC16P000735 GC16P000736 |
Summaries
for STUB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for STUB1:
STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broadrange of chaperone protein substrates for degradation (Min et al., 2008 (PubMed 18411298)).(supplied by OMIM, Jul2009)
UniProtKB/Swiss-Prot: CHIP_HUMAN, Q9UNE7Function: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation.Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length ofubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 inconcert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90.Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediatespolyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role inbase-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination andleading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and mayregulate the receptor stability and activity through proteasomal degradation
Gene Wiki entry for STUB1
|
Genomic Views
for STUB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STUB1 gene promoter:
Sp1 p53 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for STUB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STUB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3STUB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P000769: view genomic region
(about GC identifiers)
Start:
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730,115 bp from pter |
End:
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732,799 bp from pter |
Size:
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2,685 bases |
Orientation:
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plus strand |
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Proteins
for STUB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CHIP_HUMAN, Q9UNE7 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase CHIP Size: 303 amino acids; 34856 Da
Subunit: Homodimer (By similarity). Interacts with BAG2, and with the E2 ubiquitin conjugating enzymes UBE2D1, UBE2D2and UBE2D3. Interacts with the C-terminal domains of HSPA8 and HSPA1A. Detected in a ternary complex containing STUB1,HSPA1A and HSPBP1. Interacts with MKKS. Interacts with DYX1C1 and POLB. Interacts (via TPR repeats) with HSP90AA1.Interacts (when monoubiquitinated) with ATXN3. Interacts with UBE2W (By similarity). Interacts (via the U-box domain)with the UBE2V2-UBE2N heterodimer; the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interactswith DNAJB6
Subcellular location: Cytoplasm
Miscellaneous: Antibodies against STUB1 are found in patients with chronic lymphocytic leukemia (CLL) and in colorectalcancer patients
Secondary accessions: A2IDB9 O60526 Q969U2 Q9HBT1Alternative splicing: 2 isoforms: Q9UNE7-1 Q9UNE7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for STUB1: NX_Q9UNE7
Post-translational modifications:
Monoubiquitinated at Lys-2 following cell stress by UBE2W, promoting the interaction with ATXN3 (By similarity).Auto-ubiquitinated; mediated by UBE2D1 and UBE2D21
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UNE7
STUB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005852.2
ENSEMBL proteins: ENSP00000457228 ENSP00000219548 ENSP00000456591 ENSP00000456875 ENSP00000457583 ENSP00000457090 Reactome Protein details: Q9UNE7
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
STUB1 for ontologies About GeneDecksing
STUB1 Antibody Products:
Assay Products for STUB1: |
Protein
Domains /
Families
for STUB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STUB1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9UNE7ProtoNet protein and cluster: Q9UNE7 1 Blocks protein family: IPB003613 Zn-finger
UniProtKB/Swiss-Prot: CHIP_HUMAN, Q9UNE7Domain: The TPR domain is essential for ubiquitination mediated by UBE2D1Similarity: Contains 3 TPR repeatsSimilarity: Contains 1 U-box domain |
Function
for STUB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CHIP_HUMAN, Q9UNE7Function: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation.Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length ofubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 inconcert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90.Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediatespolyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role inbase-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination andleading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and mayregulate the receptor stability and activity through proteasomal degradation Genatlas biochemistry entry for STUB1:yeast STIP1 homolog and U-box containing protein 1,highly expressed in adult striated muscle,binding and interactingwith the C terminus of heat shock protein HSP70,also interacting with HSP70
Enzyme Number (IUBMB): EC 6.3.2.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STUB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STUB1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: STUB1 (NM_005861) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STUB1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STUB1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STUB1 |
Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13): About this table
STUB1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for STUB1:
Animal Models:
Mouse knock-outs for STUB1: Stub1tm1Lex Stub1tm1Atak Stub1tm1Cpat
8 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Stub1):
STUB1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for STUB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway | | | 3 | Regulation of degradation of wt-CFTR | | | 4 | Immune System | | | 5 | Proteolysis Putative ubiquitin pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for STUB1
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for STUB1
1 
Cell Signaling Technology (CST) Pathway for STUB1
4  GeneGo (Thomson Reuters) Pathways for STUB1
3  BioSystems Pathways for STUB1
5/10 
Reactome Pathways for STUB1 (see all 10)
2 
Kegg Pathways (Kegg details for STUB1):
UniProtKB/Swiss-Prot: CHIP_HUMAN, Q9UNE7Pathway: Protein modification; protein ubiquitination
STUB1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STUB1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/190 Interacting proteins for STUB1 (Q9UNE71, 2, 3 ENSP000002195484) via UniProtKB, MINT, STRING, and/or I2D (see all 190)
| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| MAP3K2 | Q9Y2U52, 3, ENSP000003434634 | MINT-8010534 MINT-8012530 MINT-8010505 MINT-8010493 MINT-8010517 MINT-8010584 MINT-7996786 MINT-8010565 MINT-8010548 MINT-8010453 I2D:
score=2 STRING: ENSP00000343463 | | HSPA8 | P111421, 2, 3, ENSP000002273784 | EBI-357085,EBI-351896 MINT-1786017 MINT-7903354 I2D:
score=4 STRING: ENSP00000227378 | | HSPA1B | P081071, 2, 3 | EBI-357085,EBI-4404728 MINT-7903424 I2D:
score=4 | | HSP90AB1 | P082382, 3, ENSP000003258754 | MINT-1786001 MINT-7903373 MINT-7904047 MINT-7904367 I2D:
score=1 STRING: ENSP00000325875 | | MAPT | P106361, 3, ENSP000003408204 | EBI-357085,EBI-366182 I2D:
score=3 STRING: ENSP00000340820 |
About this table
Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table
STUB1 for ontologies About GeneDecksing
|
Drugs & Compounds
for STUB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
STUB1 for compounds About GeneDecksing
 Browse Tocris compounds for STUB1
4 HMDB Compounds for STUB1 About this table
5 Novoseek chemical compound relationships for STUB1 gene About this table
Search CenterWatch for drugs/clinical trials and news about STUB1 / CHIP
|
Transcripts
for STUB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STUB1 gene: NM_005861.2 Unigene Cluster for STUB1: STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase Hs.592081 [show with all ESTs]Unigene Representative Sequence: NM_00586110 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000565677(uc002cit.3 uc002ciu.3) ENST00000219548 ENST00000569248
ENST00000567173 ENST00000563505 ENST00000567790 ENST00000564370 ENST00000566181
ENST00000566408 ENST00000564316
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STUB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STUB1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STUB1 (NM_005861) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STUB1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STUB1 |
Additional cDNA sequence: AF039689.1 AF129085.1 AF217968.1 AF432221.1 BC007545.1 BC017178.1 BC022788.1 BC063617.1 21 DOTS entries: DT.100723261 DT.447259 DT.100654784 DT.92453006 DT.92452998 DT.100775901 DT.120670800 DT.100654785 DT.100637940 DT.100842616 DT.92452993 DT.120670769 DT.219419 DT.100703078 DT.120670723 DT.40264699 DT.92452992 DT.95084580 DT.91788875 DT.92389737 DT.95091807 24/419 AceView cDNA sequences (see all 419): BQ637784 BM850194 BM825037 CD675035 AA604290 BM764265 CF126431 CA431336 CR625822 BU630978 CR593928 CA420352 CR603664 BF725102 BM906500 CA306234 CR608722 BM468971 AF129085 CR614839 BM557673 BF342208 T35464 BE906492
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for STUB1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b |
|---|
|
| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for STUB1
|
Expression
for STUB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STUB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACGAGCTTT
About this image
See STUB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STUB1
SOURCE GeneReport for Unigene cluster: Hs.592081
UniProtKB/Swiss-Prot: CHIP_HUMAN, Q9UNE7Tissue specificity: Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liverand lung
SABiosciences Expression via Pathway-Focused PCR Arrays including STUB1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STUB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STUB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STUB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STUB1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STUB1 |
Orthologs
for STUB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for STUB1 gene from 9/26 species (see all 26) About this table
ENSEMBL Gene Tree for STUB1 (if available)
TreeFam Gene Tree for STUB1 (if available) |
Paralogs
for STUB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STUB1 gene
- SGTB2 TTC122 SGTA2
STUB1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for STUB1
PGOHUM00000241028
|
Genomic Variants
for STUB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STUB1 (730115 - 732799 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for STUB1
10 CNVs: 49738 49727 29986 49728 3987 29982 5329 30732 29983 29985 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STUB1 |
|
Disorders
/ Diseases
for STUB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STUB1 for disorders About GeneDecksing
OMIM gene information: 607207
OMIM disorders: --
20/27  diseases for STUB1 (see all 27): About MalaCardscolon cancer multiple endocrine neoplasia amyotrophic lateral sclerosis lateral sclerosis
tauopathy lafora disease chronic lymphocytic leukemia neurodegenerative disease
chronic myeloid leukemia intrahepatic cholangiocarcinoma lymphocytic leukemia myeloid leukemia
dyslexia parkinson's disease cystic fibrosis cholangiocarcinoma
leukemia fibrosis neurodegeneration prostate cancer
5 Novoseek disease relationships for STUB1 gene About this table
Export disorders for STUB1 gene to outside databases
|
Publications
for STUB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STUB1 gene, integrated from 9 sources (see all 225):
(articles sorted by number of sources associating them with STUB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. (PubMed id 10330192)1, 2, 3, 9 Ballinger C.A....Patterson C. (1999)
- Characterization of human colon cancer antigens recognized by autologous antibodies. (PubMed id 9610721)1, 2, 3 Scanlan M.J....Old L.J. (1998)
- Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase. (PubMed id 15466472)1, 2, 9 Peng H.M....Osawa Y. (2004)
- Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. (PubMed id 16307917)1, 2, 9 Zhang M....Pearl L.H. (2005)
- MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination. (PubMed id 18094050)1, 2, 9 Hirayama S.... Nagata K. (2008)
- Ubiquitin ligase ARF-BP1/Mule modulates base excision repair. (PubMed id 19713937)1, 2 Parsons J.L....Dianov G.L. (2009)
- CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. (PubMed id 19103148)1, 2 Pabarcus M.K....Correia M.A. (2009)
- Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology. (PubMed id 18042044)1, 2 Windheim M....Cohen P. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Regulation of the cytoplasmic quality control protein degradation pathway by BAG2. (PubMed id 16169850)1, 2 Dai Q.... Patterson C. (2005)
|
External Searches for STUB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STUB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STUB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STUB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STUB1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STUB1 gene:
Search GeneIP for patents involving STUB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for STUB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for STUB1 | | OriGene shRNA RFP for STUB1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STUB1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STUB1 | | | OriGene Protein Over-expression Lysate for STUB1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STUB1 | | OriGene 3'-UTR Clone for STUB1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STUB1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STUB1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for STUB1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for STUB1 | | OriGene Custom Protein Services for STUB1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STUB1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STUB1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STUB1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STUB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STUB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STUB1 |
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| | Antibodies & Assays for STUB1 (CHIP) |
| | | | Search Tocris compounds for STUB1 |
| |  |  |  |  | | | | | | Recombinant Protein for STUB1 |
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 | | | STUB1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STUB1 |
|  |  |  | | | | ThermoFisher Antibody for STUB1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STUB1 |
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