Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STUB1 Gene

Aliases for STUB1 Gene

  • STIP1 Homology And U-Box Containing Protein 1 2 3 5
  • STIP1 Homology And U-Box Containing Protein 1, E3 Ubiquitin Protein Ligase 2 3
  • Carboxy Terminus Of Hsp70-Interacting Protein 3 4
  • STIP1 Homology And U Box-Containing Protein 1 3 4
  • CLL-Associated Antigen KW-8 3 4
  • Antigen NY-CO-7 3 4
  • CHIP 3 4
  • Heat Shock Protein A Binding Protein 2 (C-Terminal) 3
  • Serologically Defined Colon Cancer Antigen 7 3
  • E3 Ubiquitin-Protein Ligase CHIP 3
  • EC 6.3.2.- 4
  • HSPABP2 3
  • NY-CO-7 3
  • SDCCAG7 3
  • SCAR16 3
  • UBOX1 3

External Ids for STUB1 Gene

Previous GeneCards Identifiers for STUB1 Gene

  • GC16P000749
  • GC16P000670
  • GC16P000731
  • GC16P000652
  • GC16P000734
  • GC16P000735
  • GC16P000736
  • GC16P000769
  • GC16P000823
  • GC16P000848
  • GC16P000818
  • GC16P000858
  • GC16P000836

Summaries for STUB1 Gene

Entrez Gene Summary for STUB1 Gene

  • This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]

GeneCards Summary for STUB1 Gene

STUB1 (STIP1 Homology And U-Box Containing Protein 1) is a Protein Coding gene. Diseases associated with STUB1 include Spinocerebellar Ataxia, Autosomal Recessive 16 and Ataxia. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and MAPK Signaling: Oxidative Stress Pathway. GO annotations related to this gene include protein homodimerization activity and ligase activity.

UniProtKB/Swiss-Prot for STUB1 Gene

  • E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at Lys-41, Lys-61 and Lys-81, thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223).

Gene Wiki entry for STUB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STUB1 Gene

Genomics for STUB1 Gene

Regulatory Elements for STUB1 Gene

Enhancers for STUB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around STUB1 on UCSC Golden Path with GeneCards custom track

Promoters for STUB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for STUB1 Gene

Chromosome:
16
Start:
680,111 bp from pter
End:
682,870 bp from pter
Size:
2,760 bases
Orientation:
Plus strand

Genomic View for STUB1 Gene

Genes around STUB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STUB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STUB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STUB1 Gene

Proteins for STUB1 Gene

  • Protein details for STUB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNE7-CHIP_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase CHIP
    Protein Accession:
    Q9UNE7
    Secondary Accessions:
    • A2IDB9
    • O60526
    • Q969U2
    • Q9HBT1

    Protein attributes for STUB1 Gene

    Size:
    303 amino acids
    Molecular mass:
    34856 Da
    Quaternary structure:
    • Homodimer. Interacts with BAG2, and with the E2 ubiquitin conjugating enzymes UBE2D1, UBE2D2 and UBE2D3. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1. Interacts with MKKS. Interacts with DYX1C1 and POLB. Interacts (via TPR repeats) with the C-terminal domains of HSP90AA1 and HSPA8. Interacts (when monoubiquitinated) with ATXN3. Interacts with UBE2W. Interacts (via the U-box domain) with the UBE2V2-UBE2N heterodimer; the complex has a specific Lys-63-linked polyubiquitination activity. Interacts with DNAJB6. Interacts with FOXP3.
    Miscellaneous:
    • Antibodies against STUB1 are found in patients with chronic lymphocytic leukemia (CLL) and in colorectal cancer patients.

    Three dimensional structures from OCA and Proteopedia for STUB1 Gene

    Alternative splice isoforms for STUB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STUB1 Gene

Post-translational modifications for STUB1 Gene

  • Monoubiquitinated at Lys-2 following cell stress by UBE2W, promoting the interaction with ATXN3 (By similarity). Auto-ubiquitinated; mediated by UBE2D1 and UBE2D2.
  • Ubiquitination at Lys 2, Lys 22, Lys 221, and Lys 255
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STUB1 (CHIP)

No data available for DME Specific Peptides for STUB1 Gene

Domains & Families for STUB1 Gene

Suggested Antigen Peptide Sequences for STUB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UNE7

UniProtKB/Swiss-Prot:

CHIP_HUMAN :
  • The U-box domain is required for the ubiquitin protein ligase activity.
  • Contains 3 TPR repeats.
Domain:
  • The U-box domain is required for the ubiquitin protein ligase activity.
  • The TPR domain is essential for ubiquitination mediated by UBE2D1.
  • Contains 1 U-box domain.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with STUB1: view

Function for STUB1 Gene

Molecular function for STUB1 Gene

GENATLAS Biochemistry:
yeast STIP1 homolog and U-box containing protein 1,highly expressed in adult striated muscle,binding and interacting with the C terminus of heat shock protein HSP70,also interacting with HSP70
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at Lys-41, Lys-61 and Lys-81, thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223).
UniProtKB/Swiss-Prot Induction:
Up-regulated by inflammatory signals in regulatory T-cells (Treg).

Enzyme Numbers (IUBMB) for STUB1 Gene

Gene Ontology (GO) - Molecular Function for STUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 12150907
GO:0004842 ubiquitin-protein transferase activity TAS 16307917
GO:0005515 protein binding IPI 11146632
GO:0016874 ligase activity IEA --
GO:0019899 enzyme binding IPI 16280320
genes like me logo Genes that share ontologies with STUB1: view
genes like me logo Genes that share phenotypes with STUB1: view

Human Phenotype Ontology for STUB1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for STUB1 Gene

MGI Knock Outs for STUB1:

Animal Model Products

  • Taconic Biosciences Mouse Models for STUB1

CRISPR Products

miRNA for STUB1 Gene

miRTarBase miRNAs that target STUB1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for STUB1 Gene

Localization for STUB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STUB1 Gene

Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to inflammatory signals in regulatory T-cells (Treg). {ECO:0000269 PubMed:23973223}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STUB1 Gene COMPARTMENTS Subcellular localization image for STUB1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endoplasmic reticulum 5
extracellular 5
nucleus 5
plasma membrane 5
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for STUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 12150907
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 10330192
GO:0005783 endoplasmic reticulum IDA 12150907
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STUB1: view

Pathways & Interactions for STUB1 Gene

genes like me logo Genes that share pathways with STUB1: view

UniProtKB/Swiss-Prot Q9UNE7-CHIP_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for STUB1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for STUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IMP 19713937
GO:0006281 DNA repair IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IMP 19713937
GO:0006515 misfolded or incompletely synthesized protein catabolic process IDA 16831871
GO:0016567 protein ubiquitination IMP 16809764
genes like me logo Genes that share ontologies with STUB1: view

Drugs & Compounds for STUB1 Gene

(8) Drugs for STUB1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for STUB1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with STUB1: view

Transcripts for STUB1 Gene

Unigene Clusters for STUB1 Gene

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STUB1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for STUB1 Gene

GeneLoc Exon Structure for
STUB1
ECgene alternative splicing isoforms for
STUB1

Expression for STUB1 Gene

mRNA expression in normal human tissues for STUB1 Gene

Protein differential expression in normal tissues from HIPED for STUB1 Gene

This gene is overexpressed in Liver (9.8) and Retina (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STUB1 Gene



Protein tissue co-expression partners for STUB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STUB1 Gene:

STUB1

SOURCE GeneReport for Unigene cluster for STUB1 Gene:

Hs.592081

mRNA Expression by UniProt/SwissProt for STUB1 Gene:

Q9UNE7-CHIP_HUMAN
Tissue specificity: Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.
genes like me logo Genes that share expression patterns with STUB1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for STUB1 Gene

Orthologs for STUB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STUB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STUB1 34
  • 91.31 (n)
  • 97.36 (a)
STUB1 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STUB1 34
  • 90.91 (n)
  • 97.4 (a)
STUB1 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stub1 34
  • 88.34 (n)
  • 97.03 (a)
Stub1 16
Stub1 35
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STUB1 34
  • 99.78 (n)
  • 100 (a)
STUB1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stub1 34
  • 88.89 (n)
  • 97.03 (a)
oppossum
(Monodelphis domestica)
Mammalia STUB1 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves STUB1 34
  • 83.28 (n)
  • 87.79 (a)
gga-mir-6643 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STUB1 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stub1 34
  • 76.02 (n)
  • 81.19 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3752 34
zebrafish
(Danio rerio)
Actinopterygii stub1 34
  • 77.42 (n)
  • 81.16 (a)
wufc22f04 34
stub1 35
  • 80 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11175 34
fruit fly
(Drosophila melanogaster)
Insecta CHIP 36
  • 57 (a)
CHIP 34
  • 59.21 (n)
  • 58.12 (a)
CHIP 35
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008918 34
  • 63.06 (n)
  • 58.12 (a)
worm
(Caenorhabditis elegans)
Secernentea chn-1 34
  • 47.66 (n)
  • 44.14 (a)
chn-1 35
  • 40 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons CHIP 34
  • 44.07 (n)
  • 35.61 (a)
rice
(Oryza sativa)
Liliopsida Os08g0113300 34
  • 58.9 (n)
  • 60.27 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.522 34
bread mold
(Neurospora crassa)
Ascomycetes NCU10270 34
  • 46.96 (n)
  • 30 (a)
Species where no ortholog for STUB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STUB1 Gene

ENSEMBL:
Gene Tree for STUB1 (if available)
TreeFam:
Gene Tree for STUB1 (if available)

Paralogs for STUB1 Gene

Pseudogenes.org Pseudogenes for STUB1 Gene

genes like me logo Genes that share paralogs with STUB1: view

No data available for Paralogs for STUB1 Gene

Variants for STUB1 Gene

Sequence variations from dbSNP and Humsavar for STUB1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_071293 Spinocerebellar ataxia, autosomal recessive, 16 (SCAR16)
VAR_071294 Spinocerebellar ataxia, autosomal recessive, 16 (SCAR16)
VAR_071295 Spinocerebellar ataxia, autosomal recessive, 16 (SCAR16)
VAR_071296 Spinocerebellar ataxia, autosomal recessive, 16 (SCAR16)
VAR_071297 Spinocerebellar ataxia, autosomal recessive, 16 (SCAR16)

Structural Variations from Database of Genomic Variants (DGV) for STUB1 Gene

Variant ID Type Subtype PubMed ID
dgv4825n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv457310 CNV loss 19166990
nsv457311 CNV loss 19166990
nsv471063 CNV loss 18288195
nsv471065 CNV gain 18288195
nsv482181 CNV gain 20164927
nsv482182 CNV gain 20164927
nsv516590 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571012 CNV loss 21841781
nsv571016 CNV loss 21841781
nsv827480 CNV gain 20364138
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for STUB1 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STUB1 Gene

Human Gene Mutation Database (HGMD)
STUB1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STUB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STUB1 Gene

Disorders for STUB1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for STUB1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia, autosomal recessive 16
  • autosomal recessive spinocerebellar ataxia 16
ataxia
tauopathy
  • tauopathies
autosomal recessive cerebellar ataxia
chronic lymphocytic leukemia
  • b-cell chronic lymphocytic leukemia
- elite association - COSMIC cancer census association via MalaCards
Search STUB1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CHIP_HUMAN
  • Spinocerebellar ataxia, autosomal recessive, 16 (SCAR16) [MIM:615768]: Spinocerebellar ataxia defines a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR16 is characterized by truncal and limb ataxia resulting in gait instability. Additionally, patients may show dysarthria, nystagmus, spasticity of the lower limbs, and mild peripheral sensory neuropathy. {ECO:0000269 PubMed:24113144, ECO:0000269 PubMed:24312598, ECO:0000269 PubMed:24719489, ECO:0000269 PubMed:24742043, ECO:0000269 PubMed:25258038}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for STUB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STUB1
genes like me logo Genes that share disorders with STUB1: view

No data available for Genatlas for STUB1 Gene

Publications for STUB1 Gene

  1. Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. (PMID: 10330192) Ballinger C.A. … Patterson C. (Mol. Cell. Biol. 1999) 2 3 4 22 65
  2. MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination. (PMID: 18094050) Hirayama S. … Nagata K. (Mol. Biol. Cell 2008) 3 4 22 65
  3. Chaperoned ubiquitylation -- crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. (PMID: 16307917) Zhang M. … Pearl L.H. (Mol. Cell 2005) 3 4 22 65
  4. Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase. (PMID: 15466472) Peng H.M. … Osawa Y. (J. Biol. Chem. 2004) 3 4 22 65
  5. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan M.J. … Old L.J. (Int. J. Cancer 1998) 2 3 4 65

Products for STUB1 Gene

Sources for STUB1 Gene

Content
Loading form....