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Aliases for STT3B Gene

Aliases for STT3B Gene

  • STT3B, Subunit Of The Oligosaccharyltransferase Complex (Catalytic) 2 3
  • SIMP 3 4 6
  • Dolichyl-Diphosphooligosaccharide Protein Glycotransferase 2 3
  • Source Of Immunodominant MHC-Associated Peptides Homolog 3 4
  • Oligosaccharyl Transferase Subunit STT3B 3 4
  • STT3-B 3 4
  • CDG1X 3 6
  • STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog B (S. Cerevisiae) 2
  • Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit STT3B 3
  • STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog B 3
  • Source Of Immunodominant MHC Associated Peptides 2
  • Homolog Of Yeast STT3 3
  • EC 2.4.1.119 63
  • EC 2.4.99.18 4

External Ids for STT3B Gene

Summaries for STT3B Gene

Entrez Gene Summary for STT3B Gene

  • The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014]

GeneCards Summary for STT3B Gene

STT3B (STT3B, Subunit Of The Oligosaccharyltransferase Complex (Catalytic)) is a Protein Coding gene. Diseases associated with STT3B include congenital disorder of glycosylation, type ix and stt3b-cdg. Among its related pathways are Metabolism and Protein processing in endoplasmic reticulum. GO annotations related to this gene include dolichyl-diphosphooligosaccharide-protein glycotransferase activity. An important paralog of this gene is STT3A.

UniProtKB/Swiss-Prot for STT3B Gene

  • Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient cotranslational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR Asp-38 of TTR at Asn-118, leading to its degradation.

Gene Wiki entry for STT3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STT3B Gene

Genomics for STT3B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STT3B Gene

Start:
31,532,638 bp from pter
End:
31,637,622 bp from pter
Size:
104,985 bases
Orientation:
Plus strand

Genomic View for STT3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STT3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STT3B Gene

Proteins for STT3B Gene

  • Protein details for STT3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCJ2-STT3B_HUMAN
    Recommended name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
    Protein Accession:
    Q8TCJ2
    Secondary Accessions:
    • Q96JZ4
    • Q96KY7

    Protein attributes for STT3B Gene

    Size:
    826 amino acids
    Molecular mass:
    93674 Da
    Quaternary structure:
    • Component of the oligosaccharyltransferase (OST) complex (By similarity). OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.
    SequenceCaution:
    • Sequence=AAH15880.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55370.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11581.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for STT3B Gene

Proteomics data for STT3B Gene at MOPED

Post-translational modifications for STT3B Gene

  • Ubiquitination at Lys12, Lys504, Lys719, Lys749, Lys752, and Lys754
  • Glycosylation at Asn161, Asn616, Asn623, Asn627, and Asn641
  • Modification sites at PhosphoSitePlus

Other Protein References for STT3B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for STT3B Gene

Protein Domains for STT3B Gene

Suggested Antigen Peptide Sequences for STT3B Gene

Graphical View of Domain Structure for InterPro Entry

Q8TCJ2

UniProtKB/Swiss-Prot:

STT3B_HUMAN :
  • Q8TCJ2
Family:
  • Belongs to the STT3 family.
genes like me logo Genes that share domains with STT3B: view

No data available for Gene Families for STT3B Gene

Function for STT3B Gene

Molecular function for STT3B Gene

UniProtKB/Swiss-Prot CatalyticActivity: Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine
UniProtKB/Swiss-Prot Function: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient cotranslational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR Asp-38 of TTR at Asn-118, leading to its degradation.

Enzyme Numbers (IUBMB) for STT3B Gene

Gene Ontology (GO) - Molecular Function for STT3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004576 oligosaccharyl transferase activity --
GO:0004579 contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity ISS --
genes like me logo Genes that share ontologies with STT3B: view

Phenotypes for STT3B Gene

GenomeRNAi human phenotypes for STT3B:
genes like me logo Genes that share phenotypes with STT3B: view

Animal Model Products

CRISPR Products

miRNA for STT3B Gene

miRTarBase miRNAs that target STT3B

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for STT3B Gene

Localization for STT3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for STT3B Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STT3B Gene COMPARTMENTS Subcellular localization image for STT3B gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for STT3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0008250 oligosaccharyltransferase complex TAS 19167329
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STT3B: view

Pathways for STT3B Gene

genes like me logo Genes that share pathways with STT3B: view

Pathways by source for STT3B Gene

1 GeneGo (Thomson Reuters) pathway for STT3B Gene

UniProtKB/Swiss-Prot Q8TCJ2-STT3B_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for STT3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation --
GO:0006516 glycoprotein catabolic process IMP 22607976
GO:0006986 response to unfolded protein IMP 19167329
GO:0018279 protein N-linked glycosylation via asparagine ISS --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IMP 22607976
genes like me logo Genes that share ontologies with STT3B: view

Compounds for STT3B Gene

(2) HMDB Compounds for STT3B Gene

Compound Synonyms Cas Number PubMed IDs
Dolichyl diphosphate
  • Dolichyl diphosphate
37247-98-6
L-Asparagine
  • (-)-Asparagine
70-47-3
genes like me logo Genes that share compounds with STT3B: view

Transcripts for STT3B Gene

Unigene Clusters for STT3B Gene

STT3B, subunit of the oligosaccharyltransferase complex (catalytic):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STT3B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for STT3B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STT3B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b
SP1: - - -
SP2:
SP3:
SP4:

Relevant External Links for STT3B Gene

GeneLoc Exon Structure for
STT3B
ECgene alternative splicing isoforms for
STT3B

Expression for STT3B Gene

mRNA expression in normal human tissues for STT3B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STT3B Gene

SOURCE GeneReport for Unigene cluster for STT3B Gene Hs.475812

mRNA Expression by UniProt/SwissProt for STT3B Gene

Q8TCJ2-STT3B_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Expressed in skin fibroblasts (at protein level).
genes like me logo Genes that share expressions with STT3B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for STT3B Gene

Orthologs for STT3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STT3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STT3B 35
  • 99.92 (n)
  • 100 (a)
STT3B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STT3B 35
  • 93.75 (n)
  • 98.77 (a)
STT3B 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STT3B 35
  • 96.33 (n)
  • 99.39 (a)
STT3B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stt3b 35
  • 90.48 (n)
  • 97.69 (a)
Stt3b 16
Stt3b 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STT3B 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STT3B 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stt3b 35
  • 90.09 (n)
  • 97.33 (a)
chicken
(Gallus gallus)
Aves STT3B 35
  • 84.32 (n)
  • 94.97 (a)
STT3B 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STT3B 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17193 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16715 35
stt3b 35
  • 81.07 (n)
  • 92.63 (a)
zebrafish
(Danio rerio)
Actinopterygii stt3b 36
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002396 35
  • 63.34 (n)
  • 74.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta OstStt3 35
  • 65.06 (n)
  • 73.3 (a)
OstStt3 36
  • 69 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea stt-3 35
  • 62.02 (n)
  • 67.12 (a)
stt-3 36
  • 65 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR491W 35
  • 54.66 (n)
  • 57.54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STT3 35
  • 59.13 (n)
  • 57.74 (a)
STT3 36
  • 53 (a)
OneToMany
STT3 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C11627g 35
  • 58.42 (n)
  • 56.37 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7700 35
barley
(Hordeum vulgare)
Liliopsida Hv.4761 35
wheat
(Triticum aestivum)
Liliopsida Ta.9644 35
bread mold
(Neurospora crassa)
Ascomycetes NCU10497 35
  • 55.65 (n)
  • 57.08 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes stt3 35
  • 56.3 (n)
  • 54.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5942 36
  • 73 (a)
OneToOne
Species with no ortholog for STT3B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for STT3B Gene

ENSEMBL:
Gene Tree for STT3B (if available)
TreeFam:
Gene Tree for STT3B (if available)

Paralogs for STT3B Gene

Paralogs for STT3B Gene

Selected SIMAP similar genes for STT3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STT3B: view

Variants for STT3B Gene

Sequence variations from dbSNP and Humsavar for STT3B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs8020 -- 31,532,151(+) GTCAC(A/G)ACCGC upstream-variant-2KB
rs10026 -- 31,637,121(+) TGACA(A/G)TTGTC utr-variant-3-prime
rs13481 -- 31,637,333(-) ATAAA(A/G)GGTAC utr-variant-3-prime
rs1135412 -- 31,531,732(+) TAGTT(C/T)CACTC upstream-variant-2KB
rs3214835 -- 31,624,765(-) AAAAA(-/A)GTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STT3B Gene

Variant ID Type Subtype PubMed ID
nsv876670 CNV Gain 21882294
esv1008680 CNV Deletion 20482838

Relevant External Links for STT3B Gene

HapMap Linkage Disequilibrium report
STT3B
Human Gene Mutation Database (HGMD)
STT3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STT3B Gene

Disorders for STT3B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for STT3B Gene including...

Search for STT3B Gene in MalaCards »

(1) OMIM Diseases for STT3B Gene (608605)

UniProtKB/Swiss-Prot

STT3B_HUMAN
  • Congenital disorder of glycosylation 1X (CDG1X) [MIM:615597]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO:0000269 PubMed:23842455}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for STT3B

Genetic Association Database (GAD)
STT3B
Human Genome Epidemiology (HuGE) Navigator
STT3B
genes like me logo Genes that share disorders with STT3B: view

Publications for STT3B Gene

  1. The model B6dom1 minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene. (PMID: 12439619) McBride K. … Perreault C. (Immunogenetics 2002) 2 3 4 23
  2. Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms. (PMID: 19167329) Ruiz-Canada C. … Gilmore R. (Cell 2009) 3 4 23
  3. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. (PMID: 12887896) Kelleher D.J. … Gilmore R. (Mol. Cell 2003) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for STT3B Gene

Sources for STT3B Gene

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