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Aliases for STT3B Gene

Aliases for STT3B Gene

  • STT3B, Subunit Of The Oligosaccharyltransferase Complex (Catalytic) 2 3
  • Dolichyl-Diphosphooligosaccharide Protein Glycotransferase 2 3
  • Source Of Immunodominant MHC-Associated Peptides Homolog 3 4
  • Oligosaccharyl Transferase Subunit STT3B 3 4
  • STT3-B 3 4
  • SIMP 3 4
  • STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog B (S. Cerevisiae) 2
  • STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog B 3
  • Source Of Immunodominant MHC Associated Peptides 2
  • Homolog Of Yeast STT3 3
  • EC 2.4.1.119 63
  • EC 2.4.99.18 4
  • CDG1X 3

External Ids for STT3B Gene

Summaries for STT3B Gene

Entrez Gene Summary for STT3B Gene

  • The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014]

GeneCards Summary for STT3B Gene

STT3B (STT3B, Subunit Of The Oligosaccharyltransferase Complex (Catalytic)) is a Protein Coding gene. Diseases associated with STT3B include congenital disorder of glycosylation, type ix and stt3b-cdg. Among its related pathways are Metabolism and Protein processing in endoplasmic reticulum. GO annotations related to this gene include dolichyl-diphosphooligosaccharide-protein glycotransferase activity and oligosaccharyl transferase activity. An important paralog of this gene is STT3A.

UniProtKB/Swiss-Prot for STT3B Gene

  • Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient cotranslational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR Asp-38 of TTR at Asn-118, leading to its degradation.

Gene Wiki entry for STT3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STT3B Gene

Genomics for STT3B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STT3B Gene

Chromosome:
3
Start:
31,532,501 bp from pter
End:
31,637,622 bp from pter
Size:
105,122 bases
Orientation:
Plus strand

Genomic View for STT3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STT3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STT3B Gene

Proteins for STT3B Gene

  • Protein details for STT3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCJ2-STT3B_HUMAN
    Recommended name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
    Protein Accession:
    Q8TCJ2
    Secondary Accessions:
    • Q96JZ4
    • Q96KY7

    Protein attributes for STT3B Gene

    Size:
    826 amino acids
    Molecular mass:
    93674 Da
    Quaternary structure:
    • Component of the oligosaccharyltransferase (OST) complex (By similarity). OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.
    SequenceCaution:
    • Sequence=AAH15880.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55370.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11581.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for STT3B Gene

Proteomics data for STT3B Gene at MOPED

Post-translational modifications for STT3B Gene

  • Ubiquitination at Lys 719, Lys 749, Lys 752, and Lys 754
  • Glycosylation at Asn 161, Asn 616, Asn 623, Asn 627, and Asn 641
  • Modification sites at PhosphoSitePlus

Other Protein References for STT3B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for STT3B Gene

Protein Domains for STT3B Gene

Suggested Antigen Peptide Sequences for STT3B Gene

Graphical View of Domain Structure for InterPro Entry

Q8TCJ2

UniProtKB/Swiss-Prot:

STT3B_HUMAN :
  • Belongs to the STT3 family.
Family:
  • Belongs to the STT3 family.
genes like me logo Genes that share domains with STT3B: view

Function for STT3B Gene

Molecular function for STT3B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine
UniProtKB/Swiss-Prot Function:
Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient cotranslational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR Asp-38 of TTR at Asn-118, leading to its degradation.

Enzyme Numbers (IUBMB) for STT3B Gene

Gene Ontology (GO) - Molecular Function for STT3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004576 oligosaccharyl transferase activity --
GO:0004579 contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity ISS --
genes like me logo Genes that share ontologies with STT3B: view

Phenotypes for STT3B Gene

genes like me logo Genes that share phenotypes with STT3B: view

Animal Model Products

CRISPR Products

miRNA for STT3B Gene

miRTarBase miRNAs that target STT3B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STT3B

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for STT3B Gene

Localization for STT3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for STT3B Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STT3B Gene COMPARTMENTS Subcellular localization image for STT3B gene
Compartment Confidence
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for STT3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0008250 oligosaccharyltransferase complex TAS 19167329
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STT3B: view

Pathways & Interactions for STT3B Gene

genes like me logo Genes that share pathways with STT3B: view

Pathways by source for STT3B Gene

1 GeneGo (Thomson Reuters) pathway for STT3B Gene

UniProtKB/Swiss-Prot Q8TCJ2-STT3B_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for STT3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation --
GO:0006516 glycoprotein catabolic process IMP 22607976
GO:0006986 response to unfolded protein IMP 19167329
GO:0018279 protein N-linked glycosylation via asparagine ISS --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IMP 22607976
genes like me logo Genes that share ontologies with STT3B: view

No data available for SIGNOR curated interactions for STT3B Gene

Drugs & Compounds for STT3B Gene

(1) Drugs for STT3B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Asparagine Approved Nutra 0

(1) Additional Compounds for STT3B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolichyl diphosphate
  • Dolichyl diphosphate
37247-98-6
genes like me logo Genes that share compounds with STT3B: view

Transcripts for STT3B Gene

Unigene Clusters for STT3B Gene

STT3B, subunit of the oligosaccharyltransferase complex (catalytic):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STT3B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STT3B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b
SP1: - - -
SP2:
SP3:
SP4:

Relevant External Links for STT3B Gene

GeneLoc Exon Structure for
STT3B
ECgene alternative splicing isoforms for
STT3B

Expression for STT3B Gene

mRNA expression in normal human tissues for STT3B Gene

Protein differential expression in normal tissues from HIPED for STT3B Gene

This gene is overexpressed in Nasal epithelium (33.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STT3B Gene



SOURCE GeneReport for Unigene cluster for STT3B Gene Hs.475812

mRNA Expression by UniProt/SwissProt for STT3B Gene

Q8TCJ2-STT3B_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Expressed in skin fibroblasts (at protein level).
genes like me logo Genes that share expression patterns with STT3B: view

Protein tissue co-expression partners for STT3B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for STT3B Gene

Orthologs for STT3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STT3B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STT3B 35
  • 93.75 (n)
  • 98.77 (a)
STT3B 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STT3B 35
  • 96.33 (n)
  • 99.39 (a)
STT3B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stt3b 35
  • 90.48 (n)
  • 97.69 (a)
Stt3b 16
Stt3b 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STT3B 35
  • 99.92 (n)
  • 100 (a)
STT3B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stt3b 35
  • 90.09 (n)
  • 97.33 (a)
oppossum
(Monodelphis domestica)
Mammalia STT3B 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STT3B 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves STT3B 35
  • 84.32 (n)
  • 94.97 (a)
STT3B 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STT3B 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16715 35
stt3b 35
  • 81.07 (n)
  • 92.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17193 35
zebrafish
(Danio rerio)
Actinopterygii stt3b 36
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002396 35
  • 63.34 (n)
  • 74.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta OstStt3 35
  • 65.06 (n)
  • 73.3 (a)
OstStt3 36
  • 69 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea stt-3 35
  • 62.02 (n)
  • 67.12 (a)
stt-3 36
  • 65 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR491W 35
  • 54.66 (n)
  • 57.54 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C11627g 35
  • 58.42 (n)
  • 56.37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STT3 35
  • 59.13 (n)
  • 57.74 (a)
STT3 36
  • 53 (a)
OneToMany
STT3 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7700 35
barley
(Hordeum vulgare)
Liliopsida Hv.4761 35
wheat
(Triticum aestivum)
Liliopsida Ta.9644 35
bread mold
(Neurospora crassa)
Ascomycetes NCU10497 35
  • 55.65 (n)
  • 57.08 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes stt3 35
  • 56.3 (n)
  • 54.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5942 36
  • 73 (a)
OneToOne
Species with no ortholog for STT3B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for STT3B Gene

ENSEMBL:
Gene Tree for STT3B (if available)
TreeFam:
Gene Tree for STT3B (if available)

Paralogs for STT3B Gene

Paralogs for STT3B Gene

(1) SIMAP similar genes for STT3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STT3B: view

Variants for STT3B Gene

Sequence variations from dbSNP and Humsavar for STT3B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs75660900 -- 31,602,229(+) CCTAT(A/G)TATTT intron-variant
rs75671907 -- 31,539,004(+) GATCA(G/T)TTGCC intron-variant
rs75685896 -- 31,580,952(+) AAAAA(A/C)CACCT intron-variant
rs75648815 -- 31,569,609(+) CTTCA(A/G)AACAG intron-variant
rs75618680 -- 31,549,767(+) TGGAG(A/G)TTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STT3B Gene

Variant ID Type Subtype PubMed ID
nsv876670 CNV Gain 21882294
esv1008680 CNV Deletion 20482838

Variation tolerance for STT3B Gene

Residual Variation Intolerance Score: 4.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STT3B Gene

HapMap Linkage Disequilibrium report
STT3B
Human Gene Mutation Database (HGMD)
STT3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STT3B Gene

Disorders for STT3B Gene

MalaCards: The human disease database

(4) MalaCards diseases for STT3B Gene - From: OMIM, ClinVar, GeneTests, Orphanet, and DISEASES

Disorder Aliases PubMed IDs
congenital disorder of glycosylation, type ix
  • cdg1x
stt3b-cdg
  • congenital disorder of glycosylation, type ix
discitis
cartilage disease
  • cartilage disorder
- elite association
Search STT3B in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

STT3B_HUMAN
  • Congenital disorder of glycosylation 1X (CDG1X) [MIM:615597]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO:0000269 PubMed:23842455}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for STT3B

Genetic Association Database (GAD)
STT3B
Human Genome Epidemiology (HuGE) Navigator
STT3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STT3B
genes like me logo Genes that share disorders with STT3B: view

No data available for Genatlas for STT3B Gene

Publications for STT3B Gene

  1. The model B6dom1 minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene. (PMID: 12439619) McBride K. … Perreault C. (Immunogenetics 2002) 2 23 67
  2. Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms. (PMID: 19167329) Ruiz-Canada C. … Gilmore R. (Cell 2009) 23 67
  3. Cloning, characterization and expression analysis of SIMP (source of immunodominant MHC-associated peptides) in grass carp Ctenopharyngodon idella. (PMID: 18407520) Xu Z.Y. … Sun B.J. (Fish Shellfish Immunol. 2008) 23 67
  4. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. (PMID: 12887896) Kelleher D.J. … Gilmore R. (Mol. Cell 2003) 2 67
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 67

Products for STT3B Gene

Sources for STT3B Gene

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