STT3B Gene
protein-coding GIFtS: 56
GCID: GC03P031550
|
|
STT3, subunit of the oligosaccharyltransferase complex,...
| |
Aliases
for STT3B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog B (S.Cerevisiae)1 2 | | Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit STT3B2 | | SIMP1 2 3 | | Homolog Of Yeast STT32 | | STT3-B1 2 3 | | Source Of Immunodominant MHC Associated Peptides2 | | Oligosaccharyl Transferase Subunit STT3B2 3 | | EC 2.4.99.183 | | Source Of Immunodominant MHC-Associated Peptides Homolog2 3 | | EC 2.4.1.1198 | | FLJ901061 | | |
Export aliases for STT3B gene to outside databases |
Summaries
for STT3B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for STT3B:
The SIMP protein contains a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids, B6(dom1).Like ITM1 (MIM 601134), SIMP is homologous to yeast STT3, an oligosaccharyltransferase essential for cellproliferation (McBride et al., 2002 (PubMed 12439619)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: STT3B_HUMAN, Q8TCJ2Function: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a highmannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thrconsensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associateswith the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across theendoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational andpost-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficientcotranslational glycosylation and while they are less competent than STT3A-containing complexes for cotranslationalglycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A.STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites inunfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependentdegradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which arethen recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variantAMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation
Gene Wiki entry for STT3B
|
Genomic Views
for STT3B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STT3B gene promoter:
LHX3b/Lhx3b AML1a POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 c-Ets-1 FAC1 FOXJ2 (long isoform) FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for STT3B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STT3B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p23 Ensembl cytogenetic band: 3p23 HGNC cytogenetic band: 3p24.1STT3B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P031550: view genomic region
(about GC identifiers)
Start:
|
31,574,130 bp from pter |
End:
|
31,679,112 bp from pter |
Size:
|
104,983 bases |
Orientation:
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plus strand |
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Proteins
for STT3B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STT3B_HUMAN, Q8TCJ2 (See
protein sequence)Recommended Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B Size: 826 amino acids; 93674 Da
Subunit: Component of the oligosaccharyltransferase (OST) complex (By similarity). OST seems to exist in differentforms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stablecomplexes with the Sec61 complex or with both the Sec61 and TRAP complexes
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAH15880.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAB55370.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC11581.1;Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q96JZ4 Q96KY7Explore the universe of human proteins at neXtProt for STT3B: NX_Q8TCJ2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TCJ2
4/14 DME Specific Peptides for STT3B (Q8TCJ2) (see all 14)
STT3B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_849193.1
ENSEMBL proteins: ENSP00000295770
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005783 | endoplasmic reticulum |
IDA | -- | | GO:0008250 | oligosaccharyltransferase complex |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
STT3B for ontologies About GeneDecksing
STT3B Antibody Products:
Assay Products for STT3B: |
Protein
Domains /
Families
for STT3B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STT3B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TCJ2ProtoNet protein and cluster: Q8TCJ2 1 Blocks protein family: IPB003674 Oligosaccharyl transferase
UniProtKB/Swiss-Prot: STT3B_HUMAN, Q8TCJ2Similarity: Belongs to the STT3 family |
Function
for STT3B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STT3B_HUMAN, Q8TCJ2Function: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a highmannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thrconsensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associateswith the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across theendoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational andpost-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficientcotranslational glycosylation and while they are less competent than STT3A-containing complexes for cotranslationalglycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A.STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites inunfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependentdegradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which arethen recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variantAMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradationCatalytic activity: Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoproteinwith the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagineEnzyme Numbers (IUBMB): EC 2.4.1.1192 EC 2.4.99.181
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STT3B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STT3B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: STT3B (NM_178862) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STT3B | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat STT3B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STT3B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004579 | contributes to dolichyl-diphosphooligosaccharide-protein glycotransferase activity |
ISS | -- |
STT3B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for STT3B:
|
Pathways & Interactions
for STT3B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Protein processing in endoplasmic reticulum | | | 2 | Asparagine N-linked glycosylation | | | 3 | Metabolism | | | 4 | Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  GeneGo (Thomson Reuters) Pathway for STT3B
3 
Kegg Pathways (Kegg details for STT3B):
UniProtKB/Swiss-Prot: STT3B_HUMAN, Q8TCJ2Pathway: Protein modification; protein glycosylation
STT3B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STT3B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/48 Interacting proteins for STT3B (Q8TCJ23 ENSP000002957704) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006516 | glycoprotein catabolic process |
IMP | -- | | GO:0006986 | response to unfolded protein |
IMP | -- | | GO:0018279 | protein N-linked glycosylation via asparagine |
ISS | -- | | GO:0030433 | ER-associated protein catabolic process |
IMP | -- | | GO:0043686 | co-translational protein modification |
IMP | 19167329 |
STT3B for ontologies About GeneDecksing
|
Drugs & Compounds
for STT3B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STT3B
2 HMDB Compounds for STT3B About this table
Search CenterWatch for drugs/clinical trials and news about STT3B
|
Transcripts
for STT3B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STT3B gene: NM_178862.1 Unigene Cluster for STT3B: STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) Hs.475812 [show with all ESTs]Unigene Representative Sequence: AK0753807 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000453168(uc010hft.1) ENST00000295770(uc011axe.2) ENST00000423527(uc003cer.1)
ENST00000462235 ENST00000436236 ENST00000463044 ENST00000488151
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STT3B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STT3B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STT3B (NM_178862) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STT3B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat STT3B |
Additional cDNA sequence: AK027789.1 AK074587.1 AK075380.1 AK311488.1 AY074880.1 BC015880.1 15 DOTS entries: DT.218699 DT.120897844 DT.97766704 DT.100029614 DT.100825409 DT.120897891 DT.102831476 DT.120897856 DT.95178943 DT.100647126 DT.405237 DT.75103393 DT.95278120 DT.97847579 DT.40207252 24/348 AceView cDNA sequences (see all 348): AK074587 AW025865 BM556607 AW070371 AL598898 BM770121 CB161710 BM834019 BM976471 BG435273 AI274793 AA102069 BU181844 CB128931 BX473967 CD243195 BQ877881 AA099859 BM467506 NM_178862 BX097815 CR620015 BM802767 CR610915
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for STT3B About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for STT3B
|
Expression
for STT3B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STT3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAAAGATTA
About this image
See STT3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STT3B
SOURCE GeneReport for Unigene cluster: Hs.475812
UniProtKB/Swiss-Prot: STT3B_HUMAN, Q8TCJ2Tissue specificity: Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Expressed in skinfibroblasts (at protein level)
SABiosciences Custom PCR Arrays for STT3B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STT3B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STT3B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STT3B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STT3B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STT3B |
Orthologs
for STT3B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for STT3B gene from 10/37 species (see all 37) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Stt3b1 , 5 |
STT3, subunit of the oligosaccharyltransferase complex, more1, 5 |
90.71(n)1
98.05(a)1 |
|
9 (67.71 cM)5
682921 NM_024222.21 NP_077184.21
1152426075 |
chicken
(Gallus gallus) |
Aves |
STT3B1 |
STT3, subunit of the oligosaccharyltransferase complex, more |
84.39(n)
94.97(a) |
|
428444 NM_001031513.1 NP_001026684.1 |
lizard
(Anolis carolinensis) |
Reptilia |
STT3B6 |
-- |
92(a) |
1 ↔ 1 |
1(193858835-193908534) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.171932 |
Xenopus laevis, clone IMAGE4684177, mRNA |
83.16(n) |
|
BC044321.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
si:dkey-239i15.36 |
si:dkey-239i15.3 |
89(a) |
1 ↔ 1 |
16(42052001-42144277) |
fruit fly
(Drosophila melanogaster) |
Insecta |
OstStt31 |
Oligosaccharyl transferase 3 |
64.86(n)
72.96(a) |
|
43005 NM_079770.2 NP_524494.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
stt-31 |
Protein STT-3 |
62.42(n)
67.57(a) |
|
175886 NM_065961.2 NP_498362.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
STT3(YGL022W)4
STT31 |
Subunit of the oligosaccharyltransferase complex of more4
Stt3p1 |
58.69(n)1
56.91(a)1 |
|
7(452404-454560)4
8528621, 4 NP_011493.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
STT3B6STT3A6 |
dolichyl-diphosphooligosaccharide--protein glycosy...dolichyl-diphosphooligosaccharide--protein glycosy... |
54(a)46(a) |
many → 1possible ortholog |
1(12429890-12433187) 5(6652516-6658411) |
rice
(Oryza sativa) |
Liliopsida |
---- |
oligosaccharyl transferase, putative, expressed |
55(a)46(a) |
many → 1possible ortholog |
4(34306275-34311432) 5(25748605-25754597) |
ENSEMBL Gene Tree for STT3B (if available)
TreeFam Gene Tree for STT3B (if available) |
Paralogs
for STT3B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STT3B gene
- STT3A2
1 SIMAP similar gene for STT3B using alignment to 1 protein entry: STT3B_HUMAN:STT3A
STT3B for paralogs About GeneDecksing
|
Genomic Variants
for STT3B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STT3B (31574130 - 31679112 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for STT3B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STT3B |
|
Disorders
/ Diseases
for STT3B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STT3B for disorders About GeneDecksing
OMIM gene information: 608605
OMIM disorders: --
2  diseases for STT3B: About MalaCardsdiscitis osteomyelitis
Human Genome Epidemiology (HuGE) Navigator: STT3B (1 document)
Export disorders for STT3B gene to outside databases
|
Publications
for STT3B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STT3B gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with STT3B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The model B6dom1 minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene. (PubMed id 12439619)1, 2, 3, 9 McBride K.... Perreault C. (2002)
- Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. (PubMed id 12887896)1, 2, 3 Kelleher D.J.... Gilmore R. (2003)
- Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms. (PubMed id 19167329)1, 2, 9 Ruiz-Canada C....Gilmore R. (2009)
- STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. (PubMed id 22607976)1, 2 Sato T.... Kai H. (2012)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PubMed id 15835887)1, 2 Shibatani T.... Skach W.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
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External Searches for STT3B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing STT3B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing STT3B gene
(According to HUGE)
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Specialized Databases showing STT3B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for STT3B | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for STT3B gene:
Search GeneIP for patents involving STT3B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for STT3B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for STT3B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STT3B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STT3B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STT3B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STT3B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STT3B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for STT3B | | OriGene Custom Protein Services for STT3B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STT3B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STT3B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STT3B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STT3B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STT3B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STT3B |
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| | | | Search Tocris compounds for STT3B |
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 | | | STT3B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STT3B |
|  |  |  | | | | ThermoFisher Antibody for STT3B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat STT3B |
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