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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STT3B Gene

protein-coding   GIFtS: 56
GCID: GC03P031550

STT3B, Subunit Of The Oligosaccharyltransferase Complex...

(Previous names: STT3, subunit of the oligosaccharyltransferase complex,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
STT3B, Subunit Of The Oligosaccharyltransferase Complex (Catalytic)1 2     STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog B (S.
Cerevisiae)1
Dolichyl-Diphosphooligosaccharide Protein Glycotransferase1 2     Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit
STT3B2
Source Of Immunodominant MHC Associated Peptides1 2     Homolog Of Yeast STT32
Oligosaccharyl Transferase Subunit STT3B2 3     STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog B2
Source Of Immunodominant MHC-Associated Peptides Homolog2 3     EC 2.4.99.183
SIMP2 3     EC 2.4.1.1198
STT3-B2 3     

External Ids:    HGNC: 306111   Entrez Gene: 2015952   Ensembl: ENSG000001635277   OMIM: 6086055   UniProtKB: Q8TCJ23   

Export aliases for STT3B gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STT3B Gene:
The SIMP protein contains a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids,
B6(dom1). Like ITM1 (MIM 601134), SIMP is homologous to yeast STT3, an oligosaccharyltransferase essential for
cell proliferation (McBride et al., 2002 (PubMed 12439619)).(supplied by OMIM, Mar 2008)

GeneCards Summary for STT3B Gene: 
STT3B (STT3B, subunit of the oligosaccharyltransferase complex (catalytic)) is a protein-coding gene. Diseases associated with STT3B include discitis, and osteomyelitis, and among its related super-pathways are Asparagine N-linked glycosylation and Metabolism. GO annotations related to this gene include dolichyl-diphosphooligosaccharide-protein glycotransferase activity. An important paralog of this gene is STT3A.

UniProtKB/Swiss-Prot: STT3B_HUMAN, Q8TCJ2
Function: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a
high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an
Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the
complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein
translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and
mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing
complexes are required for efficient cotranslational glycosylation and while they are less competent than
STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of
some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally
and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated
degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum
proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and
targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118',
leading to its degradation

Gene Wiki entry for STT3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STT3B gene promoter:
         LHX3b/Lhx3b   AML1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   c-Ets-1   FAC1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTT3B promoter sequence
   Search SABiosciences Chromatin IP Primers for STT3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STT3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p23   Ensembl cytogenetic band:  3p23   HGNC cytogenetic band: 3p24.1

STT3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STT3B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P031550:  view genomic region     (about GC identifiers)

Start:
31,574,130 bp from pter      End:
31,679,112 bp from pter
Size:
104,983 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STT3B_HUMAN, Q8TCJ2 (See protein sequence)
Recommended Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B  
Size: 826 amino acids; 93674 Da
Subunit: Component of the oligosaccharyltransferase (OST) complex (By similarity). OST seems to exist in different
forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form
stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAH15880.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB55370.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC11581.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q96JZ4 Q96KY7

Explore the universe of human proteins at neXtProt for STT3B: NX_Q8TCJ2

Explore proteomics data for STT3B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TCJ2

  • 4/14 DME Specific Peptides for STT3B (Q8TCJ2) (see all 14)
     VMVRLML  DDFREAY  YPGLMIT  DNEGIAIF 

    STT3B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STT3B Protein Expression
    REFSEQ proteins: NP_849193.1  
    ENSEMBL proteins: 
     ENSP00000295770  

    Human Recombinant Protein Products for STT3B: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0008250oligosaccharyltransferase complex TAS19167329
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    STT3B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003674 Oligo_trans_STT3

    Graphical View of Domain Structure for InterPro Entry Q8TCJ2

    ProtoNet protein and cluster: Q8TCJ2

    1 Blocks protein domain: IPB003674 Oligosaccharyl transferase

    UniProtKB/Swiss-Prot: STT3B_HUMAN, Q8TCJ2
    Similarity: Belongs to the STT3 family


    STT3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STT3B_HUMAN, Q8TCJ2
    Function: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a
    high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an
    Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the
    complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein
    translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and
    mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing
    complexes are required for efficient cotranslational glycosylation and while they are less competent than
    STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of
    some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally
    and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated
    degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum
    proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and
    targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118',
    leading to its degradation
    Catalytic activity: Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a
    glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine

         Enzyme Numbers (IUBMB): EC 2.4.1.1192 EC 2.4.99.181

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004576oligosaccharyl transferase activity ----
    GO:0004579contributes to dolichyl-diphosphooligosaccharide-protein glycotransferase activity ISS--
         
    STT3B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for STT3B:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STT3B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    N-Glycan biosynthesis0.52
    2Metabolism
    Metabolic pathways0.40
    3CFTR folding and maturation (norm and CF)
    CFTR folding and maturation (norm and CF)0.37
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for STT3B
        CFTR folding and maturation (norm and CF)


    3         Kegg Pathways  (Kegg details for STT3B):
        N-Glycan biosynthesis
    Metabolic pathways
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: STT3B_HUMAN, Q8TCJ2
    Pathway: Protein modification; protein glycosylation


    STT3B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STT3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for STT3B (Q8TCJ23 ENSP000002957704) via UniProtKB, MINT, STRING, and/or I2D (see all 48)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPN1P048433, ENSP000002962554I2D: score=8 STRING: ENSP00000296255
    DDOSTP396563, ENSP000003641884I2D: score=7 STRING: ENSP00000364188
    ALG5Q9Y6733, ENSP000002398914I2D: score=2 STRING: ENSP00000239891
    EIF3IQ133473, ENSP000003626884I2D: score=2 STRING: ENSP00000362688
    SEC61A1P616193, ENSP000002432534I2D: score=2 STRING: ENSP00000243253
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation ----
    GO:0006516glycoprotein catabolic process IMP--
    GO:0006986response to unfolded protein IMP19167329
    GO:0018279protein N-linked glycosylation via asparagine ISS--
    GO:0030433ER-associated protein catabolic process IMP--

    STT3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    2 HMDB Compounds for STT3B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dolichyl diphosphateDolichyl diphosphate (see all 2)37247-98-6--
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--

    Search CenterWatch for drugs/clinical trials and news about STT3B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STT3B gene: 
    NM_178862.1  

    Unigene Cluster for STT3B:

    STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
    Hs.475812  [show with all ESTs]
    Unigene Representative Sequence: AK075380
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453168(uc010hft.1) ENST00000295770(uc011axe.2) ENST00000423527(uc003cer.1)
    ENST00000462235 ENST00000436236 ENST00000463044 ENST00000488151
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    Additional mRNA sequence: 

    AK027789.1 AK074587.1 AK075380.1 AK311488.1 AY074880.1 BC015880.1 

    15 DOTS entries:

    DT.218699  DT.120897844  DT.97766704  DT.100029614  DT.100825409  DT.120897891  DT.102831476  DT.120897856 
    DT.95178943  DT.100647126  DT.405237  DT.75103393  DT.95278120  DT.97847579  DT.40207252 

    24/348 AceView cDNA sequences (see all 348):

    AI274793 BX473967 CR620015 AA687743 AA371111 NM_178862 AW025865 AA921896 
    AI914841 AX799082 AA912508 BG056635 AA033629 AW468689 AI581421 CB151055 
    AI184972 BM802767 BM554958 BG656467 BP871615 AK075380 BQ877881 AA743841 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for STT3B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b
    SP1:        -                                                                 -                                               -               
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          


    ECgene alternative splicing isoforms for STT3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STT3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAAAGATTA
    STT3B Expression
    About this image


    See STT3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STT3B

    SOURCE GeneReport for Unigene cluster: Hs.475812

    UniProtKB/Swiss-Prot: STT3B_HUMAN, Q8TCJ2
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Expressed in
    skin fibroblasts (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STT3B gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stt3b1 , 5 STT3, subunit of the oligosaccharyltransferase complex, more1, 5 90.71(n)1
    98.05(a)1
      9 (67.71 cM)5
    682921  NM_024222.21  NP_077184.21 
     1152426075 
    chicken
    (Gallus gallus)
    Aves STT3B1 STT3, subunit of the oligosaccharyltransferase complex, more 84.39(n)
    94.97(a)
      428444  NM_001031513.1  NP_001026684.1 
    lizard
    (Anolis carolinensis)
    Reptilia STT3B6
    Uncharacterized protein
    92(a)
    1 ↔ 1
    1(193858835-193909339)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.171932 Xenopus laevis, clone IMAGE4684177, mRNA 83.16(n)    BC044321.1 
    zebrafish
    (Danio rerio)
    Actinopterygii STT3B6
    STT3B, subunit of the oligosaccharyltransferase co...
    89(a)
    1 ↔ 1
    16(42052001-42144277)
    fruit fly
    (Drosophila melanogaster)
    Insecta OstStt31 Oligosaccharyl transferase 3 64.86(n)
    72.96(a)
      43005  NM_079770.2  NP_524494.1 
    worm
    (Caenorhabditis elegans)
    Secernentea stt-31 Protein STT-3 62.42(n)
    67.57(a)
      175886  NM_065961.2  NP_498362.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STT3(YGL022W)4
    STT31
    Subunit of the oligosaccharyltransferase complex of more4
    Stt3p1
    58.69(n)1
    56.91(a)1
      7(452404-454560)4
    8528621, 4  NP_011493.11, 4 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.77002 Vitis vinifera transcribed sequence with weak similarity more 76.24(n)    CB979040.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.47612 Transcribed sequence with moderate similarity to protein more 74.49(n)    CB868250.1 


    ENSEMBL Gene Tree for STT3B (if available)
    TreeFam Gene Tree for STT3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STT3B gene
    STT3A2  
    1 SIMAP similar gene for STT3B using alignment to 1 protein entry:     STT3B_HUMAN:
    STT3A

    STT3B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2020 SNPs in STT3B are shown (see all 2020)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438319961,2
    --31572502(+) TTTGGA/GCTATG 1 -- us2k10--------
    rs285225251,2
    C--31572525(+) TCATCT/CTTCTC 1 -- us2k13Minor allele frequency- C:0.04WA NA 240
    rs2007750471,2
    C--31572533(+) TCTGT-/AATAAC 1 -- us2k10--------
    rs98270571,2
    C,F,H--31572759(+) TCAAAA/GTAACT 1 -- us2k117Minor allele frequency- G:0.08NS EA NA WA 2340
    rs1480826301,2
    --31572782(+) TCTAAC/TATTTT 1 -- us2k10--------
    rs762131421,2
    C--31572852(+) AGAAA-/CTATAAT 1 -- us2k10--------
    rs1873618331,2
    C--31572857(+) AATAAC/TTCAGG 1 -- us2k10--------
    rs773261611,2
    F--31572870(+) CTTTAT/CAGTTT 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1910547061,2
    --31572972(+) ACCGAA/TTACGC 1 -- us2k10--------
    rs576525681,2
    C,F--31573055(+) GCTCAT/CTTTGC 1 -- us2k12Minor allele frequency- C:0.06WA 120

    HapMap Linkage Disequilibrium report for STT3B (31574130 - 31679112 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STT3B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1008680CNV Deletion20482838
    nsv876670CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608605    OMIM disorders: --

    2 diseases for STT3B:    About MalaCards
    discitis    osteomyelitis


    STT3B for disorders           About GeneDecksing

    Genetic Association Database (GAD): STT3B
    Human Genome Epidemiology (HuGE) Navigator: STT3B (1 document)

    Export disorders for STT3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STT3B gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with STT3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The model B6dom1 minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene. (PubMed id 12439619)1, 2, 3, 9 McBride K.... Perreault C. (2002)
    2. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. (PubMed id 12887896)1, 2, 3 Kelleher D.J.... Gilmore R. (2003)
    3. Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms. (PubMed id 19167329)1, 2, 9 Ruiz-Canada C....Gilmore R. (2009)
    4. STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. (PubMed id 22607976)1, 2 Sato T.... Kai H. (2012)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PubMed id 15835887)1, 2 Shibatani T.... Skach W.R. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. OST4 is a subunit of the mammalian oligosaccharyltrans ferase required for efficient N-glycosylation. (PubMed id 23606741)1 Dumax-Vorzet A....High S. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 201595 HGNC: 30611 AceView: SIMP Ensembl:ENSG00000163527 euGenes: HUgn201595
    ECgene: STT3B Kegg: 201595 H-InvDB: STT3B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STT3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STT3B gene:
    Search GeneIP for patents involving STT3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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