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STT3B Gene

protein-coding   GIFtS: 58
GCID: GC03P031550

STT3B, Subunit Of The Oligosaccharyltransferase Complex...

(Previous names: STT3, subunit of the oligosaccharyltransferase complex,...)
  See STT3B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
STT3B, Subunit Of The Oligosaccharyltransferase Complex (Catalytic)1 2     CDG1X2 5
SIMP2 3 5     STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog B (S.
Cerevisiae)1
Dolichyl-Diphosphooligosaccharide Protein Glycotransferase1 2     Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit
STT3B2
Source Of Immunodominant MHC Associated Peptides1 2     Homolog Of Yeast STT32
Oligosaccharyl Transferase Subunit STT3B2 3     STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog B2
Source Of Immunodominant MHC-Associated Peptides Homolog2 3     EC 2.4.99.183
STT3-B2 3     EC 2.4.1.1198

External Ids:    HGNC: 306111   Entrez Gene: 2015952   Ensembl: ENSG000001635277   OMIM: 6086055   UniProtKB: Q8TCJ23   

Export aliases for STT3B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STT3B Gene:
The SIMP protein contains a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids,
B6(dom1). Like ITM1 (MIM 601134), SIMP is homologous to yeast STT3, an oligosaccharyltransferase essential for
cell proliferation (McBride et al., 2002 (PubMed 12439619)).(supplied by OMIM, Mar 2008)

GeneCards Summary for STT3B Gene:
STT3B (STT3B, subunit of the oligosaccharyltransferase complex (catalytic)) is a protein-coding gene. Diseases associated with STT3B include congenital disorder of glycosylation, type ix. GO annotations related to this gene include dolichyl-diphosphooligosaccharide-protein glycotransferase activity. An important paralog of this gene is STT3A.

UniProtKB/Swiss-Prot: STT3B_HUMAN, Q8TCJ2
Function: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a
high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an
Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the
complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein
translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and
mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing
complexes are required for efficient cotranslational glycosylation and while they are less competent than
STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of
some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally
and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated
degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum
proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and
targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118',
leading to its degradation

Gene Wiki entry for STT3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STT3B gene promoter:
         LHX3b/Lhx3b   AML1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   c-Ets-1   FAC1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTT3B promoter sequence
   Search Chromatin IP Primers for STT3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STT3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p23   Ensembl cytogenetic band:  3p23   HGNC cytogenetic band: 3p24.1

STT3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STT3B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P031550:  view genomic region     (about GC identifiers)

Start:
31,574,130 bp from pter      End:
31,679,112 bp from pter
Size:
104,983 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: STT3B_HUMAN, Q8TCJ2 (See protein sequence)
Recommended Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B  
Size: 826 amino acids; 93674 Da
Subunit: Component of the oligosaccharyltransferase (OST) complex (By similarity). OST seems to exist in different
forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form
stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes
Sequence caution: Sequence=AAH15880.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB55370.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC11581.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q96JZ4 Q96KY7

Explore the universe of human proteins at neXtProt for STT3B: NX_Q8TCJ2

Explore proteomics data for STT3B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys12, Lys504, Lys719, Lys749, Lys752, Lys754
  • Glycosylation2 at Asn161, Asn616, Asn623, Asn627, Asn641
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for STT3B (Q8TCJ2) (see all 14)
     VMVRLML  DDFREAY  YPGLMIT  DNEGIAIF 


    See STT3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_849193.1  
    ENSEMBL proteins: 
     ENSP00000295770  

    STT3B Human Recombinant Protein Products:

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    antibodies-online proteins for STT3B (2 products) 

     
    antibodies-online peptides for STT3B

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003674 Oligo_trans_STT3

    Graphical View of Domain Structure for InterPro Entry Q8TCJ2

    ProtoNet protein and cluster: Q8TCJ2

    1 Blocks protein domain: IPB003674 Oligosaccharyl transferase

    UniProtKB/Swiss-Prot: STT3B_HUMAN, Q8TCJ2
    Similarity: Belongs to the STT3 family


    Find genes that share domains with STT3B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STT3B_HUMAN, Q8TCJ2
    Function: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a
    high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an
    Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the
    complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein
    translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and
    mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing
    complexes are required for efficient cotranslational glycosylation and while they are less competent than
    STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of
    some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally
    and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated
    degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum
    proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and
    targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118',
    leading to its degradation
    Catalytic activity: Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a
    glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine

         Enzyme Numbers (IUBMB): EC 2.4.1.1192 EC 2.4.99.181

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004576oligosaccharyl transferase activity ----
    GO:0004579contributes to dolichyl-diphosphooligosaccharide-protein glycotransferase activity ISS--
         
    Find genes that share ontologies with STT3B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STT3B:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for STT3B

    miRNA
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    miRTarBase miRNAs that target STT3B:
    hsa-mir-15b-5p (MIRT046466), hsa-mir-16-5p (MIRT051229), hsa-mir-23a-3p (MIRT050418)

    Block miRNA regulation of human, mouse, rat STT3B using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STT3B_HUMAN, Q8TCJ2: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0008250oligosaccharyltransferase complex TAS19167329
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with STT3B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STT3B About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    N-Glycan biosynthesis0.49
    2Metabolism
    Metabolic pathways0.38
    3Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    CFTR folding and maturation norm and CF 0.37
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with STT3B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for STT3B
        CFTR folding and maturation (norm and CF)


    3 Kegg Pathways  (Kegg details for STT3B):
        N-Glycan biosynthesis
    Metabolic pathways
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: STT3B_HUMAN, Q8TCJ2
    Pathway: Protein modification; protein glycosylation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STT3B
    Interactions:

        Search GeneGlobe Interaction Network for STT3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STT3B (Q8TCJ23 ENSP000002957704) via UniProtKB, MINT, STRING, and/or I2D (see all 54)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPN1P048433, ENSP000002962554I2D: score=8 STRING: ENSP00000296255
    DDOSTP396563, ENSP000003641884I2D: score=7 STRING: ENSP00000364188
    ALG5Q9Y6733, ENSP000002398914I2D: score=2 STRING: ENSP00000239891
    EIF3IQ133473, ENSP000003626884I2D: score=2 STRING: ENSP00000362688
    SEC61A1P616193, ENSP000002432534I2D: score=2 STRING: ENSP00000243253
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation ----
    GO:0006516glycoprotein catabolic process IMP--
    GO:0006986response to unfolded protein IMP19167329
    GO:0018279protein N-linked glycosylation via asparagine ISS--
    GO:0030433ER-associated ubiquitin-dependent protein catabolic process IMP--

    Find genes that share ontologies with STT3B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for STT3B

    2 HMDB Compounds for STT3B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dolichyl diphosphateDolichyl diphosphate (see all 2)37247-98-6--
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STT3B gene: 
    NM_178862.1  

    Unigene Cluster for STT3B:

    STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
    Hs.475812  [show with all ESTs]
    Unigene Representative Sequence: AK075380
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453168(uc010hft.1) ENST00000295770(uc011axe.2) ENST00000423527(uc003cer.1)
    ENST00000462235 ENST00000436236 ENST00000463044 ENST00000488151
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    Additional mRNA sequence: 

    AK027789.1 AK074587.1 AK075380.1 AK311488.1 AY074880.1 BC015880.1 

    15 DOTS entries:

    DT.218699  DT.120897844  DT.97766704  DT.100029614  DT.100825409  DT.120897891  DT.102831476  DT.120897856 
    DT.95178943  DT.100647126  DT.405237  DT.75103393  DT.95278120  DT.97847579  DT.40207252 

    Selected AceView cDNA sequences (see all 348):

    CD243195 AK074587 AA883469 AA558206 BM770121 AI866416 AA743438 AA743841 
    AI274793 BX335717 AA912508 BM976471 CA868259 CF540990 CB128931 BM785621 
    BM556607 AW468689 AI085852 AA298094 BG656467 BX505156 BU156400 NM_178862 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for STT3B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b
    SP1:        -                                                                 -                                               -               
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          


    ECgene alternative splicing isoforms for STT3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STT3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAAAGATTA
    STT3B Expression
    About this image

    STT3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STT3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.475812

    UniProtKB/Swiss-Prot: STT3B_HUMAN, Q8TCJ2
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Expressed in
    skin fibroblasts (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STT3B gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stt3b1 , 5 STT3, subunit of the oligosaccharyltransferase complex, more1, 5 90.48(n)1
    97.69(a)1
      9 (67.71 cM)5
    682921  NM_024222.21  NP_077184.21 
     1152426075 
    chicken
    (Gallus gallus)
    Aves STT3B1 STT3, subunit of the oligosaccharyltransferase complex, more 84.32(n)
    94.97(a)
      428444  NM_001031513.1  NP_001026684.1 
    lizard
    (Anolis carolinensis)
    Reptilia STT3B6
    STT3B, subunit of the oligosaccharyltransferase co...
    92(a)
    1 ↔ 1
    1(193858835-193909339)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.171932 Xenopus laevis, clone IMAGE4684177, mRNA 83.16(n)    BC044321.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stt3b6
    STT3, subunit of the oligosaccharyltransferase com...
    89(a)
    1 ↔ 1
    16(42052001-42144277) ENSDARG00000001890
    fruit fly
    (Drosophila melanogaster)
    Insecta OstStt31 Oligosaccharyl transferase 3 65.06(n)
    73.3(a)
      43005  NM_079770.3  NP_524494.1 
    worm
    (Caenorhabditis elegans)
    Secernentea stt-31 stt-3 62.02(n)
    67.12(a)
      175886  NM_065961.3  NP_498362.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STT3(YGL022W)4
    STT31
    Subunit of the oligosaccharyltransferase complex of more4
    STT31
    59.13(n)1
    57.74(a)1
      7(452404-454560)4
    8528621, 4  NP_011493.11, 4 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.77002 Vitis vinifera transcribed sequence with weak similarity more 76.24(n)    CB979040.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.47612 Transcribed sequence with moderate similarity to protein more 74.49(n)    CB868250.1 


    ENSEMBL Gene Tree for STT3B (if available)
    TreeFam Gene Tree for STT3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STT3B gene
    STT3A2  
    1 SIMAP similar gene for STT3B using alignment to 1 protein entry:     STT3B_HUMAN:
    STT3A

    Find genes that share paralogs with STT3B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for STT3B (see all 2020)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438319961,2
    --31572502(+) TTTGGA/GCTATG 1 -- us2k10--------
    rs285225251,2
    C--31572525(+) TCATCT/CTTCTC 1 -- us2k13Minor allele frequency- C:0.04WA NA 240
    rs2007750471,2
    C--31572533(+) TCTGT-/AATAAC 1 -- us2k10--------
    rs98270571,2
    C,F,H--31572759(+) TCAAAA/GTAACT 1 -- us2k117Minor allele frequency- G:0.08NS EA NA WA 2340
    rs1480826301,2
    --31572782(+) TCTAAC/TATTTT 1 -- us2k10--------
    rs762131421,2
    C--31572852(+) AGAAA-/CTATAAT 1 -- us2k10--------
    rs1873618331,2
    C--31572857(+) AATAAC/TTCAGG 1 -- us2k10--------
    rs773261611,2
    F--31572870(+) CTTTAT/CAGTTT 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1910547061,2
    --31572972(+) ACCGAA/TTACGC 1 -- us2k10--------
    rs576525681,2
    C,F--31573055(+) GCTCAT/CTTTGC 1 -- us2k12Minor allele frequency- C:0.06WA 120

    HapMap Linkage Disequilibrium report for STT3B (31574130 - 31679112 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STT3B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1008680CNV Deletion20482838
    nsv876670CNV Gain21882294

    Human Gene Mutation Database (HGMD): STT3B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STT3B
    DNA2.0 Custom Variant and Variant Library Synthesis for STT3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608605   
    OMIM disorders: 615597  
    1 disease for STT3B:    
    About MalaCards
    congenital disorder of glycosylation, type ix


    Find genes that share disorders with STT3B           About GenesLikeMe

    Genetic Association Database (GAD): STT3B
    Human Genome Epidemiology (HuGE) Navigator: STT3B (1 document)

    Export disorders for STT3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STT3B gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with STT3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The model B6dom1 minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene. (PubMed id 12439619)1, 2, 3, 9 McBride K.... Perreault C. (Immunogenetics 2002)
    2. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. (PubMed id 12887896)1, 2, 3 Kelleher D.J.... Gilmore R. (Mol. Cell 2003)
    3. Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms. (PubMed id 19167329)1, 2, 9 Ruiz-Canada C.... Gilmore R. (Cell 2009)
    4. STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. (PubMed id 22607976)1, 2 Sato T.... Kai H. (Mol. Cell 2012)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PubMed id 15835887)1, 2 Shibatani T.... Skach W.R. (Biochemistry 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation. (PubMed id 23606741)1 Dumax-Vorzet A....High S. (J. Cell. Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 201595 HGNC: 30611 AceView: SIMP Ensembl:ENSG00000163527 euGenes: HUgn201595
    ECgene: STT3B Kegg: 201595 H-InvDB: STT3B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STT3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for STT3B gene:
    Search GeneIP for patents involving STT3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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