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STT3A Gene

protein-coding   GIFtS: 61
GCID: GC11P125462

STT3A, Subunit Of The Oligosaccharyltransferase Complex...

(Previous names: integral membrane protein 1, STT3, subunit of the oligosaccharyltransferase...)
(Previous symbol: ITM1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
STT3A, Subunit Of The Oligosaccharyltransferase Complex (Catalytic)1 2     STT3-A2 3
ITM11 2 3 5     STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog A (S.
Cerevisiae)1
Integral Membrane Protein 11 2 3     Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit
STT3A2
TMC2 3 5     Integral Transmembrane Protein 12
STT3A, Cataylic Subunit Of The Oligosaccharyltransferase Complex1 2     STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog A2
Dolichyl-Diphosphooligosaccharide Protein Glycotransferase1 2     Transmembrane Conserved2
Oligosaccharyl Transferase Subunit STT3A2 3     EC 2.4.99.183
Transmembrane Protein TMC2 3     EC 2.4.1.1198
B52 3     

External Ids:    HGNC: 61721   Entrez Gene: 37032   Ensembl: ENSG000001349107   OMIM: 6011345   UniProtKB: P469773   

Export aliases for STT3A gene to outside databases

Previous GC identifers: GC11P124968 GC11P121404


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STT3A Gene:
STT3A (STT3A, subunit of the oligosaccharyltransferase complex (catalytic)) is a protein-coding gene. Diseases associated with STT3A include congenital disorder of glycosylation, type iw, and nodular goiter. GO annotations related to this gene include dolichyl-diphosphooligosaccharide-protein glycotransferase activity. An important paralog of this gene is STT3B.

UniProtKB/Swiss-Prot: STT3A_HUMAN, P46977
Function: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a
high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an
Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the
complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein
translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity.
STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on
target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and
mediate glycosylation of sites that have been skipped by STT3A




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the STT3A gene promoter:
         E2F-4   E2F-3a   E2F-5   HTF   E2F-2   HNF-1A   SRY   E2F   E2F-1   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTT3A promoter sequence
   Search Chromatin IP Primers for STT3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STT3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q23.3

STT3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STT3A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P125462:  view genomic region     (about GC identifiers)

Start:
125,461,607 bp from pter      End:
125,495,110 bp from pter
Size:
33,504 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STT3A_HUMAN, P46977 (See protein sequence)
Recommended Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A  
Size: 705 amino acids; 80530 Da
Subunit: Component of the oligosaccharyltransferase (OST) complex (By similarity). OST seems to exist in different
forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form
stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Also identified as part of a
complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, VIMP, STT3A AND VCP. This contains
known members of the OST complex and may be a form of this complex
Secondary accessions: Q86XU9 Q8TE35 Q8WUB4

Explore the universe of human proteins at neXtProt for STT3A: NX_P46977

Explore proteomics data for STT3A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys3, Lys13, Lys67, Lys613, Lys641, Lys655
  • Glycosylation2 at Asn537, Asn544, Asn548
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for STT3A (P46977) (see all 19)
     VMVRLML  DDFREAY  GFDRVRN  FHSTWVT 


    See STT3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001265432.1  NP_001265433.1  NP_689926.1  

    ENSEMBL proteins: 
     ENSP00000436558   ENSP00000376472   ENSP00000436962   ENSP00000432820   ENSP00000435810  
     ENSP00000432912   ENSP00000436523  
    Reactome Protein details: P46977

    STT3A Human Recombinant Protein Products:

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    Novus Biologicals STT3A Lysate
    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    STT3A Assay Products:

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003674 Oligo_trans_STT3

    Graphical View of Domain Structure for InterPro Entry P46977

    ProtoNet protein and cluster: P46977

    1 Blocks protein domain: IPB003674 Oligosaccharyl transferase

    UniProtKB/Swiss-Prot: STT3A_HUMAN, P46977
    Similarity: Belongs to the STT3 family


    STT3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STT3A_HUMAN, P46977
    Function: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a
    high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an
    Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the
    complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein
    translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity.
    STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on
    target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and
    mediate glycosylation of sites that have been skipped by STT3A
    Catalytic activity: Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a
    glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine

         Enzyme Numbers (IUBMB): EC 2.4.1.1192 EC 2.4.99.181

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004576oligosaccharyl transferase activity ----
    GO:0004579contributes to dolichyl-diphosphooligosaccharide-protein glycotransferase activity ISS--
    GO:0005515protein binding IPI--
         
    STT3A for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for STT3A:
     Decreased Tat-dependent transc  Increased S DNA content  Increased number of mitotic ce  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STT3A
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    miRNA
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    miRTarBase miRNAs that target STT3A:
    hsa-mir-328-3p (MIRT043817), hsa-mir-124-3p (MIRT022920), hsa-mir-10a-5p (MIRT047614), hsa-mir-10b-5p (MIRT047423), hsa-mir-484 (MIRT042092)

    Block miRNA regulation of human, mouse, rat STT3A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STT3A (see all 33):
    hsa-miR-548j hsa-miR-579 hsa-miR-328 hsa-miR-3162-5p hsa-miR-124 hsa-miR-506 hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidSTT3A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STT3A

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: STT3A (NM_152713)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STT3A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STT3A

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STT3A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STT3A_HUMAN, P46977: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    chloroplast1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0008250oligosaccharyltransferase complex TAS19167329
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    STT3A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STT3A About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Post-translational protein modification0.43
    N-Glycan biosynthesis0.49
    Metabolism of proteins0.30
    2Metabolism
    Metabolic pathways0.38
    3Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    CFTR folding and maturation norm and CF 0.37
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for STT3A
        CFTR folding and maturation (norm and CF)

    1 Reactome Pathway for STT3A
        Asparagine N-linked glycosylation


    3 Kegg Pathways  (Kegg details for STT3A):
        N-Glycan biosynthesis
    Metabolic pathways
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: STT3A_HUMAN, P46977
    Pathway: Protein modification; protein glycosylation


    STT3A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STT3A
    Interactions:

        Search GeneGlobe Interaction Network for STT3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STT3A (P469771, 2, 3 ENSP000003764724) via UniProtKB, MINT, STRING, and/or I2D (see all 56)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HJURPQ8NCD32, 3, ENSP000004141094MINT-64998 I2D: score=4 STRING: ENSP00000414109
    IRAK2O431871, 3, ENSP000002564584EBI-719212,EBI-447733 I2D: score=1 STRING: ENSP00000256458
    TMEM173Q86WV61, 3, ENSP000003312884EBI-719212,EBI-2800345 I2D: score=1 STRING: ENSP00000331288
    ITM2CQ9NQX73, ENSP000003227304I2D: score=3 STRING: ENSP00000322730
    UNC93B1Q9H1C43, ENSP000002274714I2D: score=1 STRING: ENSP00000227471
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation ----
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043686co-translational protein modification IMP19167329
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    STT3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STT3A

    2 HMDB Compounds for STT3A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dolichyl diphosphateDolichyl diphosphate (see all 2)37247-98-6--
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STT3A gene (3 alternative transcripts): 
    NM_001278503.1  NM_001278504.1  NM_152713.4  

    Unigene Cluster for STT3A:

    STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
    Hs.504237  [show with all ESTs]
    Unigene Representative Sequence: BX649102
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527606 ENST00000392708(uc001qcd.2 uc001qce.2 uc010sbg.1 uc009zbn.2)
    ENST00000534472(uc009zbm.2) ENST00000529196 ENST00000531491 ENST00000525652
    ENST00000529886 ENST00000526213 ENST00000527456 ENST00000525431 ENST00000526726
    ENST00000531001 ENST00000524639 ENST00000531599 ENST00000525946 ENST00000526364

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    Selected qRT-PCR Assays for microRNAs that regulate STT3A (see all 33):
    hsa-miR-548j hsa-miR-579 hsa-miR-328 hsa-miR-3162-5p hsa-miR-124 hsa-miR-506 hsa-miR-548d-5p hsa-miR-548a-5p
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    GenScript: all cDNA clones in your preferred vector: STT3A (NM_152713)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat STT3A
      QuantiFast Probe-based Assays in human, mouse, rat STT3A

    Additional mRNA sequence: 

    AK130548.1 AK290040.1 AK290657.1 AK295892.1 AK308902.1 BC020965.2 BC048348.1 BT007100.1 
    BX649102.1 L38961.1 L47337.1 

    Selected DOTS entries (see all 25):

    DT.100818237  DT.451821  DT.120738662  DT.100645980  DT.100731817  DT.120738564  DT.100799749  DT.120738588 
    DT.92437840  DT.100818238  DT.120738670  DT.120738727  DT.95321402  DT.95268317  DT.120738569  DT.120738699 
    DT.91735931  DT.91740998  DT.100030836  DT.100683957  DT.100803332  DT.40211173  DT.95135946  DT.95361526 

    Selected AceView cDNA sequences (see all 290):

    BE731222 AU132199 AI242988 AU121542 BQ933930 BM828499 BE280269 CK824878 
    NM_152713 BM451846 BM667548 AU133024 CK824877 BF870815 BU543738 AA355454 
    BM717673 AA721496 AU280002 AU124479 CD672394 BP356762 BM553035 CB117345 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STT3A (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^
    SP1:                          -     -     -     -     -                       -                       -                                                         
    SP2:                                            -     -                       -                       -                                                         
    SP3:                                                                                                                                                        -   
    SP4:                          -     -     -     -     -     -                 -                       -                                                         
    SP5:                          -     -           -     -     -                 -                       -                                                         

    ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
    SP1:  -                                                                     
    SP2:  -                                                                     
    SP3:  -                                                                     
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for STT3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STT3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTTACTTT
    STT3A Expression
    About this image

    STT3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STT3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.504237

    UniProtKB/Swiss-Prot: STT3A_HUMAN, P46977
    Tissue specificity: Expressed at high levels in placenta, liver, muscle and pancreas, and at very low levels in
    brain, lung and kidney. Expressed in skin fibroblasts (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STT3A gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stt3a1 , 5 STT3, subunit of the oligosaccharyltransferase complex, more1, 5 92.72(n)1
    99.43(a)1
      9 (20.67 cM)5
    164301  NM_008408.41  NP_032434.31 
     367293445 
    chicken
    (Gallus gallus)
    Aves LOC1008571651 dolichyl-diphosphooligosaccharide--protein glycosyltransferase more 82.36(n)
    98.58(a)
      100857165  XM_004947955.1  XP_004948012.1 
    lizard
    (Anolis carolinensis)
    Reptilia STT3A6
    STT3A, subunit of the oligosaccharyltransferase co...
    96(a)
    1 ↔ 1
    GL343322.1(812723-825080)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043914.12   -- 81.35(n)    BC043914.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.78582 Danio rerio mRNA similar to intergral membrane protein more 81.66(n)    BC046072.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15181 CG1518 69.55(n)
    77.95(a)
      33082  NM_134581.1  NP_608425.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STT36
    Subunit of the oligosaccharyltransferase complex o...
    51(a)
    1 → many
    VII(452404-454560) YGL022W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons STT3B1 STT3B 60.65(n)
    62.45(a)
      840312  NM_103136.3  NP_174675.2 
    rice
    (Oryza sativa)
    Liliopsida Os.61902 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.12(n)    AK099138.1 


    ENSEMBL Gene Tree for STT3A (if available)
    TreeFam Gene Tree for STT3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STT3A gene
    STT3B2  
    1 SIMAP similar gene for STT3A using alignment to 6 protein entries:     STT3A_HUMAN (see all proteins):
    STT3B

    STT3A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STT3A
    PGOHUM00000248157


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STT3A (see all 659)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1876058821,2
    --125460907(+) AGATGG/TGGTTT 1 -- us2k10--------
    rs1122064961,2
    C--125460920(+) CCATGC/TTGGTG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1903396101,2
    --125460970(+) CCTCGA/GCCTCC 1 -- us2k10--------
    rs1816894161,2
    --125460977(+) CTCCCA/TAAGTG 1 -- us2k10--------
    rs12936721,2
    C,F,H--125461034(-) AAGTAC/TTAACC 1 -- us2k1 tfbs324Minor allele frequency- T:0.15NS EA NA WA CSA 2206
    rs1379514031,2
    --125461381(+) GGATTA/GCAGGG 1 -- us2k10--------
    rs5456731,2
    C,F,A,H--125461497(-) TGTTCC/GATGTA 1 -- us2k130Minor allele frequency- G:0.50MN NS EA NA CSA 2905
    rs1454233311,2
    C--125461502(+) CGAAC-/ACTT  
            
    ACTAC
    1 -- us2k10--------
    rs1901366841,2
    --125461552(+) CATAAC/GGTCCT 1 -- us2k10--------
    rs5481811,2
    C,F,O,A,H--125461709(+) CTGCGG/AGACGT 1 -- us2k134Minor allele frequency- A:0.18EA MN NS NA WA CSA 3081

    HapMap Linkage Disequilibrium report for STT3A (125461607 - 125495110 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for STT3A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv32964CNV Gain+Loss17666407

    Human Gene Mutation Database (HGMD): STT3A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STT3A
    DNA2.0 Custom Variant and Variant Library Synthesis for STT3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601134   
    OMIM disorders: 615596  
    11 diseases for STT3A:    
    About MalaCards
    congenital disorder of glycosylation, type iw    nodular goiter    goiter    thyroid adenoma
    adenoma    thyroiditis    schizophrenia    hiv-1
    endotheliitis    malaria    hepatitis

    1 disease from the University of Copenhagen DISEASES database for STT3A:
    Thyroid adenoma

    STT3A for disorders           About GeneDecksing

    Genetic Association Database (GAD): STT3A
    Human Genome Epidemiology (HuGE) Navigator: STT3A (1 document)

    Export disorders for STT3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STT3A gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with STT3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC. (PubMed id 8634329)1, 2, 3 Lissy N.A....Testa J.R. (Biochim. Biophys. Acta 1996)
    2. Molecular cloning of a highly conserved mouse and human integral membrane protein (Itm1) and genetic mapping to mouse chromosome 9. (PubMed id 8838310)1, 2, 9 Hong G....Merregaert J. (Genomics 1996)
    3. Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms. (PubMed id 19167329)1, 2, 9 Ruiz-Canada C.... Gilmore R. (Cell 2009)
    4. Assignment of the human integral transmembrane protein 1 gene (ITM1) to human chromosome band 11q23.3 by in situ hybridization and YAC mapping. (PubMed id 8941377)1, 3, 9 Van Hul W....Merregaert J. (Cytogenet. Cell Genet. 1996)
    5. Genome-wide association study identifies five new schizophrenia loci. (PubMed id 21926974)1, 4 (Nat. Genet. 2011)
    6. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PubMed id 15835887)1, 2 Shibatani T.... Skach W.R. (Biochemistry 2005)
    7. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. (PubMed id 12887896)1, 2 Kelleher D.J.... Gilmore R. (Mol. Cell 2003)
    8. Schizosaccharomyces pombe stt3+ is a functional homologue of Saccharomyces cerevisiae STT3 which regulates oligosaccharyltransferase activity. (PubMed id 10234787)1, 3 Yoshida S....Anraku Y. (Yeast 1999)
    9. OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation. (PubMed id 23606741)1 Dumax-Vorzet A....High S. (J. Cell. Sci. 2013)
    10. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PubMed id 23453885)1 (Lancet 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3703 HGNC: 6172 AceView: ITM1 Ensembl:ENSG00000134910 euGenes: HUgn3703
    ECgene: STT3A Kegg: 3703 H-InvDB: STT3A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STT3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STT3A gene:
    Search GeneIP for patents involving STT3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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