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Aliases for STT3A Gene

Aliases for STT3A Gene

  • STT3A, Subunit Of The Oligosaccharyltransferase Complex (Catalytic) 2 3
  • Integral Membrane Protein 1 2 3 4
  • ITM1 3 4 6
  • TMC 3 4 6
  • STT3A, Cataylic Subunit Of The Oligosaccharyltransferase Complex 2 3
  • Dolichyl-Diphosphooligosaccharide Protein Glycotransferase 2 3
  • Oligosaccharyl Transferase Subunit STT3A 3 4
  • Transmembrane Protein TMC 3 4
  • STT3-A 3 4
  • B5 3 4
  • STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog A (S. Cerevisiae) 2
  • Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit STT3A 3
  • STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog A 3
  • Integral Transmembrane Protein 1 3
  • Transmembrane Conserved 3
  • EC 2.4.1.119 63
  • EC 2.4.99.18 4

External Ids for STT3A Gene

Previous HGNC Symbols for STT3A Gene

  • ITM1

Previous GeneCards Identifiers for STT3A Gene

  • GC11P124968
  • GC11P125462
  • GC11P121404

Summaries for STT3A Gene

GeneCards Summary for STT3A Gene

STT3A (STT3A, Subunit Of The Oligosaccharyltransferase Complex (Catalytic)) is a Protein Coding gene. Diseases associated with STT3A include congenital disorder of glycosylation, type iw and stt3a-cdg. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include dolichyl-diphosphooligosaccharide-protein glycotransferase activity. An important paralog of this gene is STT3B.

UniProtKB/Swiss-Prot for STT3A Gene

  • Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and mediate glycosylation of sites that have been skipped by STT3A.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STT3A Gene

Genomics for STT3A Gene

Regulatory Elements for STT3A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STT3A Gene

Start:
125,591,712 bp from pter
End:
125,625,215 bp from pter
Size:
33,504 bases
Orientation:
Plus strand

Genomic View for STT3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STT3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STT3A Gene

Proteins for STT3A Gene

  • Protein details for STT3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46977-STT3A_HUMAN
    Recommended name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
    Protein Accession:
    P46977
    Secondary Accessions:
    • B4DJ24
    • E9PNQ1
    • Q86XU9
    • Q8TE35
    • Q8WUB4

    Protein attributes for STT3A Gene

    Size:
    705 amino acids
    Molecular mass:
    80530 Da
    Quaternary structure:
    • Component of the oligosaccharyltransferase (OST) complex (By similarity). OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Also identified as part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, VIMP, STT3A AND VCP. This contains known members of the OST complex and may be a form of this complex.

    Alternative splice isoforms for STT3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STT3A Gene

Proteomics data for STT3A Gene at MOPED

Post-translational modifications for STT3A Gene

  • Ubiquitination at Lys3, Lys13, Lys67, Lys613, Lys641, and Lys655
  • Glycosylation at Asn537, Asn544, and Asn548
  • Modification sites at PhosphoSitePlus

Other Protein References for STT3A Gene

Domains for STT3A Gene

Protein Domains for STT3A Gene

Suggested Antigen Peptide Sequences for STT3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P46977

UniProtKB/Swiss-Prot:

STT3A_HUMAN :
  • P46977
Family:
  • Belongs to the STT3 family.
genes like me logo Genes that share domains with STT3A: view

No data available for Gene Families for STT3A Gene

Function for STT3A Gene

Molecular function for STT3A Gene

UniProtKB/Swiss-Prot CatalyticActivity: Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine
UniProtKB/Swiss-Prot Function: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and mediate glycosylation of sites that have been skipped by STT3A.

Enzyme Numbers (IUBMB) for STT3A Gene

Gene Ontology (GO) - Molecular Function for STT3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004576 oligosaccharyl transferase activity --
GO:0004579 contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity ISS --
GO:0005515 protein binding IPI 21903422
genes like me logo Genes that share ontologies with STT3A: view
genes like me logo Genes that share phenotypes with STT3A: view

Animal Model Products

CRISPR Products

miRNA for STT3A Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STT3A

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for STT3A Gene

Localization for STT3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for STT3A Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STT3A Gene COMPARTMENTS Subcellular localization image for STT3A gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
chloroplast 1
nucleus 1

Gene Ontology (GO) - Cellular Components for STT3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0008250 oligosaccharyltransferase complex TAS 19167329
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STT3A: view

Pathways for STT3A Gene

genes like me logo Genes that share pathways with STT3A: view

Pathways by source for STT3A Gene

UniProtKB/Swiss-Prot P46977-STT3A_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for STT3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043686 co-translational protein modification IMP 19167329
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with STT3A: view

Compounds for STT3A Gene

(2) HMDB Compounds for STT3A Gene

Compound Synonyms Cas Number PubMed IDs
Dolichyl diphosphate
  • Dolichyl diphosphate
37247-98-6
L-Asparagine
  • (-)-Asparagine
70-47-3
genes like me logo Genes that share compounds with STT3A: view

Transcripts for STT3A Gene

Unigene Clusters for STT3A Gene

STT3A, subunit of the oligosaccharyltransferase complex (catalytic):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STT3A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STT3A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^
SP1: - - - - - - -
SP2: - - - -
SP3: -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8:
SP9: - - - - - - - - -
SP10: - - - -
SP11: -
SP12: -
SP13: -
SP14:

ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - -
SP13:
SP14: -

Relevant External Links for STT3A Gene

GeneLoc Exon Structure for
STT3A
ECgene alternative splicing isoforms for
STT3A

Expression for STT3A Gene

mRNA expression in normal human tissues for STT3A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STT3A Gene

SOURCE GeneReport for Unigene cluster for STT3A Gene Hs.504237

mRNA Expression by UniProt/SwissProt for STT3A Gene

P46977-STT3A_HUMAN
Tissue specificity: Expressed at high levels in placenta, liver, muscle and pancreas, and at very low levels in brain, lung and kidney. Expressed in skin fibroblasts (at protein level).
genes like me logo Genes that share expressions with STT3A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for STT3A Gene

Orthologs for STT3A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STT3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STT3A 35
  • 99.72 (n)
  • 100 (a)
STT3A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STT3A 35
  • 92.81 (n)
  • 99.01 (a)
STT3A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STT3A 35
  • 94.47 (n)
  • 99.57 (a)
STT3A 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stt3a 35
  • 92.72 (n)
  • 99.43 (a)
Stt3a 16
Stt3a 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STT3A 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STT3A 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stt3a 35
  • 92.48 (n)
  • 99.43 (a)
chicken
(Gallus gallus)
Aves LOC100857165 35
  • 82.36 (n)
  • 98.58 (a)
STT3A 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STT3A 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stt3a 35
  • 81.42 (n)
  • 97.87 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.7858 35
itm1 35
  • 81.47 (n)
  • 96.45 (a)
itm1 36
  • 96 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000434 35
  • 68.76 (n)
  • 77.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1518 35
  • 69.55 (n)
  • 77.95 (a)
CG1518 36
  • 76 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STT3 36
  • 51 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons STT3B 35
  • 60.65 (n)
  • 62.45 (a)
corn
(Zea mays)
Liliopsida Zm.3652 35
rice
(Oryza sativa)
Liliopsida Os.6190 35
Os04g0675500 35
  • 61.63 (n)
  • 61.19 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.22774 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6149 36
  • 70 (a)
OneToOne
Species with no ortholog for STT3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for STT3A Gene

ENSEMBL:
Gene Tree for STT3A (if available)
TreeFam:
Gene Tree for STT3A (if available)

Paralogs for STT3A Gene

Paralogs for STT3A Gene

Selected SIMAP similar genes for STT3A Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for STT3A Gene

genes like me logo Genes that share paralogs with STT3A: view

Variants for STT3A Gene

Sequence variations from dbSNP and Humsavar for STT3A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs15272 -- 125,621,203(-) AGTTT(C/T)CCTGA utr-variant-3-prime
rs473468 -- 125,621,690(-) TACAA(C/T)AGCAA utr-variant-3-prime
rs477961 -- 125,607,483(-) CTATC(A/G)GATAT intron-variant
rs479967 -- 125,615,473(-) tccat(C/T)tgtgg intron-variant
rs490602 -- 125,612,142(-) tccca(A/G)cactt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STT3A Gene

Variant ID Type Subtype PubMed ID
esv32964 CNV Gain+Loss 17666407

Relevant External Links for STT3A Gene

HapMap Linkage Disequilibrium report
STT3A
Human Gene Mutation Database (HGMD)
STT3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STT3A Gene

Disorders for STT3A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for STT3A Gene including...

Search for STT3A Gene in MalaCards »

(1) OMIM Diseases for STT3A Gene (601134)

UniProtKB/Swiss-Prot

STT3A_HUMAN
  • Congenital disorder of glycosylation 1W (CDG1W) [MIM:615596]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO:0000269 PubMed:23842455}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for STT3A Gene

Relevant External Links for STT3A

Genetic Association Database (GAD)
STT3A
Human Genome Epidemiology (HuGE) Navigator
STT3A
genes like me logo Genes that share disorders with STT3A: view

Publications for STT3A Gene

  1. Molecular cloning of a highly conserved mouse and human integral membrane protein (Itm1) and genetic mapping to mouse chromosome 9. (PMID: 8838310) Hong G. … Merregaert J. (Genomics 1996) 3 4 23
  2. Assignment of the human integral transmembrane protein 1 gene (ITM1) to human chromosome band 11q23.3 by in situ hybridization and YAC mapping. (PMID: 8941377) Van Hul W. … Merregaert J. (Cytogenet. Cell Genet. 1996) 2 3 23
  3. Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms. (PMID: 19167329) Ruiz-Canada C. … Gilmore R. (Cell 2009) 3 4 23
  4. Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC. (PMID: 8634329) Lissy N.A. … Testa J.R. (Biochim. Biophys. Acta 1996) 2 3 4
  5. Schizosaccharomyces pombe stt3+ is a functional homologue of Saccharomyces cerevisiae STT3 which regulates oligosaccharyltransferase activity. (PMID: 10234787) Yoshida S. … Anraku Y. (Yeast 1999) 2 3

Products for STT3A Gene

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