STT3A Gene
protein-coding GIFtS: 59
GCID: GC11P125462
|
|
STT3, subunit of the oligosaccharyltransferase complex,...(Previous name: integral membrane protein 1 )
(Previous symbol: ITM1)
| |
Aliases
for STT3A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog A (S.Cerevisiae)1 2 | | B52 3 | | ITM11 2 3 5 | | MGC90421 | | TMC1 2 3 5 | | Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit STT3A2 | | Integral Membrane Protein 11 2 3 | | Integral Transmembrane Protein 12 | | STT3-A1 2 3 | | Transmembrane Conserved2 | | Oligosaccharyl Transferase Subunit STT3A2 3 | | EC 2.4.99.183 | | Transmembrane Protein TMC2 3 | | EC 2.4.1.1198 |
Export aliases for STT3A gene to outside databasesPrevious GC identifers: GC11P124968 GC11P121404 |
Summaries
for STT3A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: STT3A_HUMAN, P46977Function: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a highmannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thrconsensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associateswith the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across theendoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in themajority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, whileSTT3B-containing complexes are required for efficient cotranslational glycosylation and mediate glycosylation of sitesthat have been skipped by STT3A
|
Genomic Views
for STT3A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STT3A gene promoter:
E2F-4 E2F-3a E2F-5 HTF E2F-2 HNF-1A SRY E2F E2F-1 HNF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for STT3A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STT3A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q24.2 HGNC cytogenetic band: 11q23.3STT3A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P125462: view genomic region
(about GC identifiers)
Start:
|
125,461,607 bp from pter |
End:
|
125,495,110 bp from pter |
Size:
|
33,504 bases |
Orientation:
|
plus strand |
|
Proteins
for STT3A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STT3A_HUMAN, P46977 (See
protein sequence)Recommended Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A Size: 705 amino acids; 80530 Da
Subunit: Component of the oligosaccharyltransferase (OST) complex (By similarity). OST seems to exist in differentforms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stablecomplexes with the Sec61 complex or with both the Sec61 and TRAP complexes
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: Q86XU9 Q8TE35 Q8WUB4Explore the universe of human proteins at neXtProt for STT3A: NX_P46977
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P46977
4/19 DME Specific Peptides for STT3A (P46977) (see all 19)
STT3A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689926.1
ENSEMBL proteins: ENSP00000436558 ENSP00000376472 ENSP00000436962 ENSP00000432820 ENSP00000435810 ENSP00000432912 ENSP00000436523 Reactome Protein details: P46977
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
STT3A for ontologies About GeneDecksing
STT3A Antibody Products:
Assay Products for STT3A: |
Protein
Domains /
Families
for STT3A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STT3A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P46977ProtoNet protein and cluster: P46977 1 Blocks protein family: IPB003674 Oligosaccharyl transferase
UniProtKB/Swiss-Prot: STT3A_HUMAN, P46977Similarity: Belongs to the STT3 family |
Function
for STT3A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STT3A_HUMAN, P46977Function: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a highmannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thrconsensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associateswith the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across theendoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in themajority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, whileSTT3B-containing complexes are required for efficient cotranslational glycosylation and mediate glycosylation of sitesthat have been skipped by STT3ACatalytic activity: Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoproteinwith the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagineEnzyme Numbers (IUBMB): EC 2.4.1.1192 EC 2.4.99.181
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STT3A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STT3A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: STT3A (NM_152713) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STT3A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STT3A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STT3A |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004576 | oligosaccharyl transferase activity |
-- | -- | | GO:0004579 | contributes to dolichyl-diphosphooligosaccharide-protein glycotransferase activity |
ISS | -- | | GO:0005515 | protein binding |
IPI | -- |
STT3A for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for STT3A:
|
Pathways & Interactions
for STT3A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Asparagine N-linked glycosylation | | | 2 | Protein processing in endoplasmic reticulum | | | 3 | Metabolism | | | 4 | Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  GeneGo (Thomson Reuters) Pathway for STT3A
3 
Reactome Pathways for STT3A
3 
Kegg Pathways (Kegg details for STT3A):
UniProtKB/Swiss-Prot: STT3A_HUMAN, P46977Pathway: Protein modification; protein glycosylation
STT3A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STT3A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/47 Interacting proteins for STT3A (P469771, 2, 3 ENSP000003764724) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| HJURP | Q8NCD32, 3, ENSP000004141094 | MINT-64998 I2D:
score=4 STRING: ENSP00000414109 | | IRAK2 | O431871, 3, ENSP000002564584 | EBI-719212,EBI-447733 I2D:
score=1 STRING: ENSP00000256458 | | TMEM173 | Q86WV61, 3, ENSP000003312884 | EBI-719212,EBI-2800345 I2D:
score=1 STRING: ENSP00000331288 | | ITM2C | Q9NQX73, ENSP000003227304 | I2D:
score=3 STRING: ENSP00000322730 | | UNC93B1 | Q9H1C43, ENSP000002274714 | I2D:
score=1 STRING: ENSP00000227471 |
About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006486 | protein glycosylation |
-- | -- | | GO:0018279 | protein N-linked glycosylation via asparagine |
TAS | -- | | GO:0043686 | co-translational protein modification |
IMP | 19167329 | | GO:0043687 | post-translational protein modification |
TAS | -- | | GO:0044267 | cellular protein metabolic process |
TAS | -- |
STT3A for ontologies About GeneDecksing
|
Drugs & Compounds
for STT3A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STT3A
2 HMDB Compounds for STT3A About this table
Search CenterWatch for drugs/clinical trials and news about STT3A
|
Transcripts
for STT3A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STT3A gene: NM_152713.3 Unigene Cluster for STT3A: STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) Hs.504237 [show with all ESTs]Unigene Representative Sequence: BX64910216 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000527606 ENST00000392708(uc001qcd.2 uc001qce.2 uc010sbg.1 uc009zbn.2)
ENST00000534472(uc009zbm.2) ENST00000529196 ENST00000531491 ENST00000525652
ENST00000529886 ENST00000526213 ENST00000527456 ENST00000525431 ENST00000526726
ENST00000531001 ENST00000524639 ENST00000531599 ENST00000525946 ENST00000526364
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STT3A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STT3A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STT3A (NM_152713) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STT3A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STT3A |
Additional cDNA sequence: AK130548.1 AK290040.1 AK290657.1 AK295892.1 AK308902.1 BC020965.2 BC048348.1 BT007100.1 BX649102.1 L38961.1 L47337.1 24/25 DOTS entries (see all 25): DT.100818237 DT.451821 DT.120738662 DT.100645980 DT.100731817 DT.120738564 DT.100799749 DT.120738588 DT.92437840 DT.100818238 DT.120738670 DT.120738727 DT.95321402 DT.95268317 DT.120738569 DT.120738699 DT.91735931 DT.91740998 DT.100030836 DT.100683957 DT.100803332 DT.40211173 DT.95135946 DT.95361526 24/290 AceView cDNA sequences (see all 290): AU133024 BU187396 BC048348 AL602646 CK824878 BM451846 AA346951 BE280269 BU552592 BU543738 BM553035 NM_152713 BX284031 AI468512 CD672394 BP357994 AI242988 BC020965 AU132725 BM717673 AA482371 BT007100 AA939083 AU137739
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for STT3A (see all 14) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | - | | - | | - | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | |
| ExUns: | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | · | 21c | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b |
|---|
|
| SP1: | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for STT3A
|
Expression
for STT3A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STT3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTTTACTTT
About this image
See STT3A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STT3A
SOURCE GeneReport for Unigene cluster: Hs.504237
UniProtKB/Swiss-Prot: STT3A_HUMAN, P46977Tissue specificity: Expressed at high levels in placenta, liver, muscle and pancreas, and at very low levels in brain,lung and kidney. Expressed in skin fibroblasts (at protein level)
SABiosciences Custom PCR Arrays for STT3A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STT3A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STT3A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STT3A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STT3A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STT3A |
Orthologs
for STT3A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for STT3A gene from 7/31 species (see all 31) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008571651 |
dolichyl-diphosphooligosaccharide--protein glycosyltransferase more |
82.36(n)
98.58(a) |
|
100857165 XM_003642606.1 XP_003642654.1 |
lizard
(Anolis carolinensis) |
Reptilia |
STT3A6 |
-- |
98(a) |
1 ↔ 1 |
GL343322.1(812921-823756) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC043914.12 |
-- |
81.35(n) |
|
BC043914.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.78582 |
Danio rerio mRNA similar to intergral membrane protein more |
81.66(n) |
|
BC046072.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG15181 |
CG1518 |
69.55(n)
77.95(a) |
|
33082 NM_134581.1 NP_608425.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
STT3B1 |
dolichyl-diphosphooligosaccharide--protein glycosyltransferase |
60.11(n)
61.51(a) |
|
840312 NM_103136.3 NP_174675.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.61902 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
75.12(n) |
|
AK099138.1 |
ENSEMBL Gene Tree for STT3A (if available)
TreeFam Gene Tree for STT3A (if available) |
Paralogs
for STT3A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STT3A gene
- STT3B2
1 SIMAP similar gene for STT3A using alignment to 6 protein entries: STT3A_HUMAN (see all proteins):STT3B
STT3A for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for STT3A
PGOHUM00000248157
|
Genomic Variants
for STT3A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STT3A (125461607 - 125495110 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for STT3A
3 CNVs: 86069 86068 6905 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STT3A |
|
Disorders
/ Diseases
for STT3A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STT3A for disorders About GeneDecksing
OMIM gene information: 601134
OMIM disorders: --
5  diseases for STT3A: About MalaCardsnodular goiter goiter thyroiditis hepatitis
malaria
1 disease from the University of Copenhagen DISEASES database for STT3A:Thyroid adenoma Human Genome Epidemiology (HuGE) Navigator: STT3A (1 document)
Export disorders for STT3A gene to outside databases
|
Publications
for STT3A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STT3A gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with STT3A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC. (PubMed id 8634329)1, 2, 3 Lissy N.A....Testa J.R. (1996)
- Molecular cloning of a highly conserved mouse and human integral membrane protein (Itm1) and genetic mapping to mouse chromosome 9. (PubMed id 8838310)1, 2, 9 Hong G....Merregaert J. (1996)
- Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms. (PubMed id 19167329)1, 2, 9 Ruiz-Canada C....Gilmore R. (2009)
- Assignment of the human integral transmembrane protein 1 gene (ITM1) to human chromosome band 11q23.3 by in situ hybridization and YAC mapping. (PubMed id 8941377)1, 3, 9 Van Hul W....Merregaert J. (1996)
- Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PubMed id 15835887)1, 2 Shibatani T.... Skach W.R. (2005)
- Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. (PubMed id 12887896)1, 2 Kelleher D.J.... Gilmore R. (2003)
- Schizosaccharomyces pombe stt3+ is a functional homologue of Saccharomyces cerevisiae STT3 which regulates oligosaccharyltransferase activity. (PubMed id 10234787)1, 3 Yoshida S....Anraku Y. (1999)
- The new molecular markers DDIT3, STT3A, ARG2 and FAM12 9A are not useful in diagnosing thyroid follicular tumors. (PubMed id 22157935)1 Sigstad E....Warren D.J. (2012)
- Proteomic identification of common SCF ubiquitin ligas e FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (2012)
- Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
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External Searches for STT3A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing STT3A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing STT3A gene
(According to HUGE)
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Specialized Databases showing STT3A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for STT3A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for STT3A gene:
Search GeneIP for patents involving STT3A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for STT3A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STT3A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STT3A | | | OriGene Protein Over-expression Lysate for STT3A | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for STT3A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STT3A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STT3A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for STT3A | | OriGene Custom Protein Services for STT3A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STT3A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STT3A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STT3A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STT3A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STT3A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STT3A |
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| | | | Search Tocris compounds for STT3A |
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 | | | STT3A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STT3A |
|  |  |  | | | | Search ThermoFisher Antibodies for STT3A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STT3A |
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