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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STT3A Gene

protein-coding   GIFtS: 59
GCID: GC11P125462

STT3A, Subunit Of The Oligosaccharyltransferase Complex...

(Previous names: integral membrane protein 1, STT3, subunit of the oligosaccharyltransferase...)
(Previous symbol: ITM1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
STT3A, Subunit Of The Oligosaccharyltransferase Complex (Catalytic)1 2     STT3-A2 3
ITM11 2 3 5     STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog A (S.
Cerevisiae)1
Integral Membrane Protein 11 2 3     Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit
STT3A2
TMC2 3 5     Integral Transmembrane Protein 12
STT3A, Cataylic Subunit Of The Oligosaccharyltransferase Complex1 2     STT3, Subunit Of The Oligosaccharyltransferase Complex, Homolog A2
Dolichyl-Diphosphooligosaccharide Protein Glycotransferase1 2     Transmembrane Conserved2
Oligosaccharyl Transferase Subunit STT3A2 3     EC 2.4.99.183
Transmembrane Protein TMC2 3     EC 2.4.1.1198
B52 3     

External Ids:    HGNC: 61721   Entrez Gene: 37032   Ensembl: ENSG000001349107   OMIM: 6011345   UniProtKB: P469773   

Export aliases for STT3A gene to outside databases

Previous GC identifers: GC11P124968 GC11P121404


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for STT3A Gene: 
STT3A (STT3A, subunit of the oligosaccharyltransferase complex (catalytic)) is a protein-coding gene. Diseases associated with STT3A include nodular goiter, and goiter, and among its related super-pathways are WNT ligand biogenesis and trafficking and Signaling by GPCR. GO annotations related to this gene include protein binding and dolichyl-diphosphooligosaccharide-protein glycotransferase activity. An important paralog of this gene is STT3B.

UniProtKB/Swiss-Prot: STT3A_HUMAN, P46977
Function: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a
high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an
Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the
complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein
translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity.
STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on
target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and
mediate glycosylation of sites that have been skipped by STT3A




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STT3A gene promoter:
         E2F-4   E2F-3a   E2F-5   HTF   E2F-2   HNF-1A   SRY   E2F   E2F-1   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTT3A promoter sequence
   Search SABiosciences Chromatin IP Primers for STT3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STT3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q23.3

STT3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STT3A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P125462:  view genomic region     (about GC identifiers)

Start:
125,461,607 bp from pter      End:
125,495,110 bp from pter
Size:
33,504 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STT3A_HUMAN, P46977 (See protein sequence)
Recommended Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A  
Size: 705 amino acids; 80530 Da
Subunit: Component of the oligosaccharyltransferase (OST) complex (By similarity). OST seems to exist in different
forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form
stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: Q86XU9 Q8TE35 Q8WUB4

Explore the universe of human proteins at neXtProt for STT3A: NX_P46977

Explore proteomics data for STT3A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P46977

  • 4/19 DME Specific Peptides for STT3A (P46977) (see all 19)
     VMVRLML  DDFREAY  GFDRVRN  FHSTWVT 

    STT3A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STT3A Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001265432.1  NP_001265433.1  NP_689926.1  

    ENSEMBL proteins: 
     ENSP00000436558   ENSP00000376472   ENSP00000436962   ENSP00000432820   ENSP00000435810  
     ENSP00000432912   ENSP00000436523  
    Reactome Protein details: P46977
    Human Recombinant Protein Products for STT3A: 
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    Novus Biologicals STT3A Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0008250oligosaccharyltransferase complex TAS19167329
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    STT3A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003674 Oligo_trans_STT3

    Graphical View of Domain Structure for InterPro Entry P46977

    ProtoNet protein and cluster: P46977

    1 Blocks protein domain: IPB003674 Oligosaccharyl transferase

    UniProtKB/Swiss-Prot: STT3A_HUMAN, P46977
    Similarity: Belongs to the STT3 family


    STT3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STT3A_HUMAN, P46977
    Function: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a
    high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an
    Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the
    complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein
    translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity.
    STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on
    target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and
    mediate glycosylation of sites that have been skipped by STT3A
    Catalytic activity: Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a
    glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine

         Enzyme Numbers (IUBMB): EC 2.4.1.1192 EC 2.4.99.181

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004576oligosaccharyl transferase activity ----
    GO:0004579contributes to dolichyl-diphosphooligosaccharide-protein glycotransferase activity ISS--
    GO:0005515protein binding IPI--
         
    STT3A for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for STT3A:
     Decreased Tat-dependent transc  Increased S DNA content  Increased number of mitotic ce  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for STT3A 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSTT3A 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STT3A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    N-Glycan biosynthesis0.52
    WNT ligand biogenesis and trafficking0.77
    Post-translational protein modification0.44
    Signaling by Wnt0.62
    Metabolism of proteins0.35
    2Signaling by GPCR
    Signal Transduction0.55
    3Metabolism
    Metabolic pathways0.40
    4CFTR folding and maturation (norm and CF)
    CFTR folding and maturation (norm and CF)0.37
    5Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for STT3A
        CFTR folding and maturation (norm and CF)

    5/6        Reactome Pathways for STT3A (see all 6)
        Signaling by Wnt
    Asparagine N-linked glycosylation
    Signal Transduction
    Metabolism of proteins
    Post-translational protein modification


    3         Kegg Pathways  (Kegg details for STT3A):
        N-Glycan biosynthesis
    Metabolic pathways
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: STT3A_HUMAN, P46977
    Pathway: Protein modification; protein glycosylation


    STT3A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STT3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for STT3A (P469771, 2, 3 ENSP000003764724) via UniProtKB, MINT, STRING, and/or I2D (see all 47)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HJURPQ8NCD32, 3, ENSP000004141094MINT-64998 I2D: score=4 STRING: ENSP00000414109
    IRAK2O431871, 3, ENSP000002564584EBI-719212,EBI-447733 I2D: score=1 STRING: ENSP00000256458
    TMEM173Q86WV61, 3, ENSP000003312884EBI-719212,EBI-2800345 I2D: score=1 STRING: ENSP00000331288
    ITM2CQ9NQX73, ENSP000003227304I2D: score=3 STRING: ENSP00000322730
    UNC93B1Q9H1C43, ENSP000002274714I2D: score=1 STRING: ENSP00000227471
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation ----
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043686co-translational protein modification IMP19167329
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    STT3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for STT3A

    2 HMDB Compounds for STT3A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dolichyl diphosphateDolichyl diphosphate (see all 2)37247-98-6--
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--

    Search CenterWatch for drugs/clinical trials and news about STT3A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STT3A gene (3 alternative transcripts): 
    NM_001278503.1  NM_001278504.1  NM_152713.4  

    Unigene Cluster for STT3A:

    STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
    Hs.504237  [show with all ESTs]
    Unigene Representative Sequence: BX649102
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527606 ENST00000392708(uc001qcd.2 uc001qce.2 uc010sbg.1 uc009zbn.2)
    ENST00000534472(uc009zbm.2) ENST00000529196 ENST00000531491 ENST00000525652
    ENST00000529886 ENST00000526213 ENST00000527456 ENST00000525431 ENST00000526726
    ENST00000531001 ENST00000524639 ENST00000531599 ENST00000525946 ENST00000526364

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    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate STT3A (see all 33):
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    Additional mRNA sequence: 

    AK130548.1 AK290040.1 AK290657.1 AK295892.1 AK308902.1 BC020965.2 BC048348.1 BT007100.1 
    BX649102.1 L38961.1 L47337.1 

    24/25 DOTS entries (see all 25):

    DT.100818237  DT.451821  DT.120738662  DT.100645980  DT.100731817  DT.120738564  DT.100799749  DT.120738588 
    DT.92437840  DT.100818238  DT.120738670  DT.120738727  DT.95321402  DT.95268317  DT.120738569  DT.120738699 
    DT.91735931  DT.91740998  DT.100030836  DT.100683957  DT.100803332  DT.40211173  DT.95135946  DT.95361526 

    24/290 AceView cDNA sequences (see all 290):

    CK824878 BM717673 AA482269 BQ548649 BP356762 BM553035 BM451400 BM698260 
    AA939083 BP357782 AA482371 BM905824 BM667548 AI468512 CA487523 BU187396 
    BU552592 CR606556 BE503634 NM_152713 BM837803 BM834169 BX284031 AA721496 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for STT3A (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^
    SP1:                          -     -     -     -     -                       -                       -                                                         
    SP2:                                            -     -                       -                       -                                                         
    SP3:                                                                                                                                                        -   
    SP4:                          -     -     -     -     -     -                 -                       -                                                         
    SP5:                          -     -           -     -     -                 -                       -                                                         

    ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
    SP1:  -                                                                     
    SP2:  -                                                                     
    SP3:  -                                                                     
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for STT3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STT3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTTACTTT
    STT3A Expression
    About this image


    See STT3A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STT3A

    SOURCE GeneReport for Unigene cluster: Hs.504237

    UniProtKB/Swiss-Prot: STT3A_HUMAN, P46977
    Tissue specificity: Expressed at high levels in placenta, liver, muscle and pancreas, and at very low levels in
    brain, lung and kidney. Expressed in skin fibroblasts (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STT3A gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stt3a1 , 5 STT3, subunit of the oligosaccharyltransferase complex, more1, 5 92.72(n)1
    99.43(a)1
      9 (20.67 cM)5
    164301  NM_008408.41  NP_032434.31 
     367312755 
    chicken
    (Gallus gallus)
    Aves LOC1008571651 dolichyl-diphosphooligosaccharide--protein glycosyltransferase more 82.36(n)
    98.58(a)
      100857165  XM_003642606.1  XP_003642654.1 
    lizard
    (Anolis carolinensis)
    Reptilia STT3A6
    Uncharacterized protein
    96(a)
    1 ↔ 1
    GL343322.1(812723-825080)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043914.12   -- 81.35(n)    BC043914.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.78582 Danio rerio mRNA similar to intergral membrane protein more 81.66(n)    BC046072.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15181 CG1518 69.55(n)
    77.95(a)
      33082  NM_134581.1  NP_608425.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STT36
    Subunit of the oligosaccharyltransferase complex o...
    50(a)
    1 → many
    VII(452404-454560)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons STT3B1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase 60.11(n)
    61.51(a)
      840312  NM_103136.3  NP_174675.2 
    rice
    (Oryza sativa)
    Liliopsida Os.61902 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.12(n)    AK099138.1 


    ENSEMBL Gene Tree for STT3A (if available)
    TreeFam Gene Tree for STT3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STT3A gene
    STT3B2  
    1 SIMAP similar gene for STT3A using alignment to 6 protein entries:     STT3A_HUMAN (see all proteins):
    STT3B

    STT3A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STT3A
    PGOHUM00000248157


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/659 SNPs in STT3A are shown (see all 659)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1876058821,2
    --125460907(+) AGATGG/TGGTTT 1 -- us2k10--------
    rs1122064961,2
    C--125460920(+) CCATGC/TTGGTG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1903396101,2
    --125460970(+) CCTCGA/GCCTCC 1 -- us2k10--------
    rs1816894161,2
    --125460977(+) CTCCCA/TAAGTG 1 -- us2k10--------
    rs12936721,2
    C,F,H--125461034(-) AAGTAC/TTAACC 1 -- us2k1 tfbs324Minor allele frequency- T:0.15NS EA NA WA CSA 2206
    rs1379514031,2
    --125461381(+) GGATTA/GCAGGG 1 -- us2k10--------
    rs5456731,2
    C,F,A,H--125461497(-) TGTTCC/GATGTA 1 -- us2k130Minor allele frequency- G:0.50MN NS EA NA CSA 2905
    rs1454233311,2
    C--125461502(+) CGAAC-/ACTT  
            
    ACTAC
    1 -- us2k10--------
    rs1901366841,2
    --125461552(+) CATAAC/GGTCCT 1 -- us2k10--------
    rs5481811,2
    C,F,O,A,H--125461709(+) CTGCGG/AGACGT 1 -- us2k134Minor allele frequency- A:0.18EA MN NS NA WA CSA 3081

    HapMap Linkage Disequilibrium report for STT3A (125461607 - 125495110 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for STT3A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv32964CNV Gain+Loss17666407

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601134    OMIM disorders: --

    7 diseases for STT3A:    About MalaCards
    nodular goiter    goiter    thyroid adenoma    thyroiditis
    adenoma    endotheliitis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for STT3A:
    Thyroid adenoma

    STT3A for disorders           About GeneDecksing

    Genetic Association Database (GAD): STT3A
    Human Genome Epidemiology (HuGE) Navigator: STT3A (1 document)

    Export disorders for STT3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STT3A gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with STT3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC. (PubMed id 8634329)1, 2, 3 Lissy N.A....Testa J.R. (1996)
    2. Molecular cloning of a highly conserved mouse and human integral membrane protein (Itm1) and genetic mapping to mouse chromosome 9. (PubMed id 8838310)1, 2, 9 Hong G....Merregaert J. (1996)
    3. Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms. (PubMed id 19167329)1, 2, 9 Ruiz-Canada C....Gilmore R. (2009)
    4. Assignment of the human integral transmembrane protein 1 gene (ITM1) to human chromosome band 11q23.3 by in situ hybridization and YAC mapping. (PubMed id 8941377)1, 3, 9 Van Hul W....Merregaert J. (1996)
    5. Genome-wide association study identifies five new schi zophrenia loci. (PubMed id 21926974)1, 4 (2011)
    6. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PubMed id 15835887)1, 2 Shibatani T.... Skach W.R. (2005)
    7. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. (PubMed id 12887896)1, 2 Kelleher D.J.... Gilmore R. (2003)
    8. Schizosaccharomyces pombe stt3+ is a functional homologue of Saccharomyces cerevisiae STT3 which regulates oligosaccharyltransferase activity. (PubMed id 10234787)1, 3 Yoshida S....Anraku Y. (1999)
    9. OST4 is a subunit of the mammalian oligosaccharyltrans ferase required for efficient N-glycosylation. (PubMed id 23606741)1 Dumax-Vorzet A....High S. (2013)
    10. Identification of risk loci with shared effects on fiv e major psychiatric disorders: a genome-wide analysis. (PubMed id 23453885)1  ....Sullivan P.F. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3703 HGNC: 6172 AceView: ITM1 Ensembl:ENSG00000134910 euGenes: HUgn3703
    ECgene: STT3A Kegg: 3703 H-InvDB: STT3A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STT3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STT3A gene:
    Search GeneIP for patents involving STT3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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