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STS Gene

protein-coding   GIFtS: 68
GCID: GC0XP007147

Steroid Sulfatase (Microsomal), Isozyme S

(Previous names: steroid sulfatase (microsomal), arylsulfatase C, isozyme...)
(Previous symbol: ARSC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Steroid Sulfatase (Microsomal), Isozyme S1 2     XLI2 5
ARSC11 2 3 5     Steroid Sulfatase (Microsomal), Arylsulfatase C, Isozyme S1
Arylsulfatase C1 2 3     ES2
Steryl-Sulfate Sulfohydrolase2 3     Estrone Sulfatase2
ASC2 3     steryl-sulfatase2
EC 3.1.6.23 8     Steroid Sulfatase3
ARSC2 5     EC 3.1.68
SSDD2 5     

External Ids:    HGNC: 114251   Entrez Gene: 4122   Ensembl: ENSG000001018467   OMIM: 3007475   UniProtKB: P088423   

Export aliases for STS gene to outside databases

Previous GC identifers: GC0XP002655 GC0XP005924 GC0XP006533 GC0XP006599 GC0XP006997 GC0XP004994


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STS Gene:
The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to estrogens during
pregnancy. The encoded protein is found in the endoplasmic reticulum, where it acts as a homodimer. Mutations in
this gene are known to cause X-linked ichthyosis (XLI). (provided by RefSeq, Jul 2008)

GeneCards Summary for STS Gene:
STS (steroid sulfatase (microsomal), isozyme S) is a protein-coding gene. Diseases associated with STS include x-linked ichthyosis, and endometriosis of ovary. GO annotations related to this gene include steryl-sulfatase activity and sulfuric ester hydrolase activity. An important paralog of this gene is ARSF.

UniProtKB/Swiss-Prot: STS_HUMAN, P08842
Function: Conversion of sulfated steroid precursors to estrogens during pregnancy

Gene Wiki entry for STS (Steroid sulfatase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STS gene promoter:
         SRF   SRF (504 AA)   MyoD   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTS promoter sequence
   Search Chromatin IP Primers for STS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.32   Ensembl cytogenetic band:  Xp22.31   HGNC cytogenetic band: Xp22.32

STS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STS gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP007147:  view genomic region     (about GC identifiers)

Start:
7,137,472 bp from pter      End:
7,272,851 bp from pter
Size:
135,380 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STS_HUMAN, P08842 (See protein sequence)
Recommended Name: Steryl-sulfatase precursor  
Size: 583 amino acids; 65492 Da
Cofactor: Binds 1 calcium ion per subunit
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for STS:
1P49 (3D)    
Secondary accessions: B2RA47

Explore the universe of human proteins at neXtProt for STS: NX_P08842

Explore proteomics data for STS at MOPED

Post-translational modifications: 

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in
    prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)1
  • Glycosylation2 at Asn47, Asn259
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for STS (P08842) (see all 5)
     NGIYKGG  HDPPLLFD  HEFLFHYC  WEGGIRVPG 


    See STS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000342.2  
    ENSEMBL proteins: 
     ENSP00000217961  
    Reactome Protein details: P08842

    STS Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARS: Arylsulfatase family

    4 InterPro protein domains:
     IPR000917 Sulfatase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR024607 Sulfatase_CS
     IPR017850 Alkaline_phosphatase_core

    Graphical View of Domain Structure for InterPro Entry P08842

    ProtoNet protein and cluster: P08842

    1 Blocks protein domain: IPB000917 Sulfatase

    UniProtKB/Swiss-Prot: STS_HUMAN, P08842
    Similarity: Belongs to the sulfatase family


    STS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STS_HUMAN, P08842
    Function: Conversion of sulfated steroid precursors to estrogens during pregnancy
    Catalytic activity: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H(2)O = 3-beta-hydroxyandrost-5-en-17-one +
    sulfate

         Genatlas biochemistry entry for STS:
    steroid,arylsulfatase C,X-linked,steroid sulfatase,microsomal,slow isoform,membrane bound,escaping inactivation

         Enzyme Numbers (IUBMB): EC 3.1.6.21 2 EC 3.1.62

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004773steryl-sulfatase activity TAS--
    GO:0008484sulfuric ester hydrolase activity IDA15962010
    GO:0046872metal ion binding IEA--
         
    STS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for STS:
     Increased S DNA content, incre 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STS

    miRNA
    Products:
        
    miRTarBase miRNAs that target STS:
    hsa-mir-148b-3p (MIRT019334)

    Block miRNA regulation of human, mouse, rat STS using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate STS:
    hsa-miR-1304 hsa-miR-579 hsa-miR-205 hsa-miR-9* hsa-miR-33b hsa-miR-1299 hsa-miR-33a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STS

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for STS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STS (NM_000351)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STS

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STS_HUMAN, P08842: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome4
    golgi apparatus4
    lysosome4
    plasma membrane4
    vacuole4
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome TAS2668275
    GO:0005768endosome TAS2668275
    GO:0005783endoplasmic reticulum TAS2668275
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005789endoplasmic reticulum membrane TAS--

    STS for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STS About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Glycosphingolipid metabolism0.56
    2Estrone metabolism
    Estrone metabolism0.57
    Androstenedione and testosterone biosynthesis and metabolism p.10.57
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4PTM- gamma carboxylation, hypusine formation and arylsulfatase activation
    PTM- gamma carboxylation, hypusine formation and arylsulfatase activation0.31
    The activation of arylsulfatases0.00
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for STS
        Estrone metabolism
    Androstenedione and testosterone biosynthesis and metabolism p.1

    1 BioSystems Pathway for STS
        Estrogen metabolism

    2 Reactome Pathways for STS
        Glycosphingolipid metabolism
    The activation of arylsulfatases

    1 PharmGKB Pathway for STS
        Aromatase Inhibitor Pathway (Multiple Tissues), Pharmacodynamics

    1 Kegg Pathway  (Kegg details for STS):
        Steroid hormone biosynthesis


    STS for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STS
    Interactions:

        GeneGlobe Interaction Network for STS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STS (P088422, 3 ENSP000002179614) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLP226812, 3, ENSP000002640334MINT-50474 I2D: score=1 STRING: ENSP00000264033
    CYP11A1P051082, ENSP000002680534MINT-4054731 STRING: ENSP00000268053
    ATP6V1B2P212812, ENSP000002763904MINT-4054731 STRING: ENSP00000276390
    A2MP010232MINT-4054731
    ACTBP607092MINT-4054731
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006687glycosphingolipid metabolic process TAS--
    GO:0006706steroid catabolic process TAS6957717
    GO:0007565female pregnancy IEA--
    GO:0008152metabolic process ----

    STS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STS

    8 HMDB Compounds for STS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Androsterone sulfate3alpha-Sulfate-5alpha-androstan-17-one (see all 8)2479-86-9--
    CalciumCa (see all 2)7440-70-2--
    DHEA sulfate(3beta)-3-(sulfooxy)-Androst-5-en-17-one (see all 16)651-48-9--
    Dehydroepiandrosterone(+)-Dehydroisoandrosterone (see all 42)53-43-0--
    Estrone(+)-Estrone (see all 7)53-16-7--
    Estrone sulfateConestoral (see all 12)481-97-0--
    SulfateSulfate (ion 2-) (see all 9)14808-79-8--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for STS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Norelgestromin-- 53016-31-2enzymeinhibitor15172700 15860265 12711003
    2-Amino-3-Oxo-4-Sulfo-Butyric Acid-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for STS gene (see all 64)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrone sulfate 95.4 89 1912612 (3), 2212823 (2), 11070351 (2), 16132094 (2) (see all 57)
    667-coumate 94.3 15 10910045 (2), 16533785 (2), 19112542 (1), 17268815 (1) (see all 8)
    estrone 93.6 337 10215035 (9), 9044848 (8), 7696150 (7), 9654650 (7) (see all 99)
    estrone-3-o-sulfamate 91.5 13 9544207 (1), 10215035 (1), 11886493 (1), 12751816 (1) (see all 10)
    17beta-hydroxysteroid 90.3 75 8388710 (4), 14979917 (3), 20151319 (2), 18817841 (2) (see all 41)
    steroid 88.7 881 17604157 (11), 11087571 (9), 16178010 (9), 15355916 (8) (see all 99)
    estradiol sulfate 86.9 4 16864173 (1), 19130396 (1), 14684318 (1)
    nomegestrol acetate 84.6 6 8918978 (3), 16080533 (1), 14670645 (1), 15767920 (1)
    promegestone 83.5 1 14670645 (1)
    medrogestone 83.5 1 14670645 (1)



    STS for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STS gene: 
    NM_000351.4  

    Unigene Cluster for STS:

    Steroid sulfatase (microsomal), isozyme S
    Hs.522578  [show with all ESTs]
    Unigene Representative Sequence: M16505
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000217961(uc004crw.2 uc011mhp.1 uc004crx.1 uc004cry.4)

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate STS:
    hsa-miR-1304 hsa-miR-579 hsa-miR-205 hsa-miR-9* hsa-miR-33b hsa-miR-1299 hsa-miR-33a
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      QuantiTect SYBR Green Assays in human, mouse, rat STS
      QuantiFast Probe-based Assays in human, mouse, rat STS

    Additional mRNA sequence: 

    AK314034.1 AM282551.1 BC075030.2 DQ851171.1 J04964.1 M16505.1 M17591.1 

    9 DOTS entries:

    DT.95269263  DT.317742  DT.121281914  DT.121281959  DT.99948730  DT.121281931  DT.95269252  DT.95269264 
    DT.95269265 

    Selected AceView cDNA sequences (see all 200):

    CB250477 AU138166 AI015899 AU135888 AU158312 AI221028 BM723000 AI635578 
    BQ018705 BF194867 M17591 BI770964 BC075030 AU137974 AA975782 CB852158 
    F01424 AU136945 BQ184961 AU139261 CB159619 AI147055 AI192461 AL133910 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTGCAGG
    STS Expression
    About this image


    STS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Liver (Hepatobiliary System)
     
     Placenta (Extraembryonic Tissues)
     
     Larynx (Respiratory System)
    STS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522578
        Custom PCR Arrays for STS
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for STS
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STS gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sts5 steroid sulfatase   --   XY -
    chicken
    (Gallus gallus)
    Aves STS1 steroid sulfatase (microsomal), isozyme S 67.97(n)
    66.37(a)
      418654  XM_004938427.1  XP_004938484.1 
    lizard
    (Anolis carolinensis)
    Reptilia STS6
    steroid sulfatase (microsomal), isozyme S
    64(a)
    1 ↔ 1
    3(117250437-117364284)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.327282 Xenopus laevis transcribed sequence with weak similarity more 75.05(n)    BJ624198.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sec61a2 Danio rerio, clone IMAGE5914856, mRNA, partial cds 72.82(n)    BC049491.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sul-26
    Protein SUL-2 (sul-2) mRNA, complete cds
    29(a)
    1 → many
    V(8157746-8159874) WBGene00006309


    ENSEMBL Gene Tree for STS (if available)
    TreeFam Gene Tree for STS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STS gene
    ARSF2  ARSI2  ARSJ2  ARSG2  ARSA2  ARSH2  ARSB2  GALNS2  
    ARSE2  ARSD2  
    5 SIMAP similar genes for STS using alignment to 5 protein entries:     STS_HUMAN (see all proteins):
    ARSE    ARSH    ARSD    ARSF    IDS

    STS for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STS
    PGOHUM00000233967


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STS (see all 1941)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0140204
    Ichthyosis, X-linked (IXL)4--see VAR_0140202 W S mis40--------
    VAR_0072414
    Ichthyosis, X-linked (IXL)4--see VAR_0072412 W R mis40--------
    VAR_0140224
    Ichthyosis, X-linked (IXL)4--see VAR_0140222 H R mis40--------
    VAR_0140214
    Ichthyosis, X-linked (IXL)4--see VAR_0140212 G R mis40--------
    VAR_0140234
    Ichthyosis, X-linked (IXL)4--see VAR_0140232 Q P mis40--------
    VAR_0072424
    Ichthyosis, X-linked (IXL)4--see VAR_0072422 C Y mis40--------
    VAR_0072404
    Ichthyosis, X-linked (IXL)4--see VAR_0072402 S L mis40--------
    rs343078281,2
    C--7145489(+) TTTTT-/TATAAA 1 -- int10--------
    rs1513156921,2
    --7148964(+) ATGTCA/GGCCCC 1 -- us2k10--------
    rs1405955131,2
    --7149113(+) TTTTGA/GCTCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for STS (7137472 - 7272851 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for STS:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678334CNV Deletion23128226
    esv2657313CNV Deletion23128226
    nsv9931CNV Gain18304495
    dgv2435e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): STS
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STS
    DNA2.0 Custom Variant and Variant Library Synthesis for STS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300747   
    OMIM disorders: 308100  
    UniProtKB/Swiss-Prot: STS_HUMAN, P08842
  • Ichthyosis, X-linked (IXL) [MIM:308100]: A keratinization disorder manifesting with mild erythroderma and
    generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal,
    dark brown scales, especially on the neck, extremities, trunk, and buttocks. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • Selected diseases for STS (see all 58):    
    About MalaCards
    x-linked ichthyosis    endometriosis of ovary    schneckenbecken dysplasia    clear cell adenocarcinoma
    unilateral renal agenesis    anencephaly    ovarian clear cell adenocarcinoma    smith-lemli-opitz syndrome
    ichthyosis vulgaris    adrenocorticotropic hormone deficiency    endometriosis    renal agenesis
    periventricular nodular heterotopia    cryptorchidism    kallmann syndrome    metachromatic leukodystrophy
    leukodystrophy    osteochondrodysplasia    dysostosis    congenital ichthyosiform erythroderma

    6 diseases from the University of Copenhagen DISEASES database for STS:
    X-linked ichthyosis     Ichthyosis vulgaris     Breast cancer     Ocular albinism
    Hypogonadism     Schneckenbecken dysplasia

    STS for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for STS gene (see all 47)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ichthyosis x-linked 97.5 98 11231321 (7), 10692123 (5), 16196306 (4), 2080119 (2) (see all 48)
    ichthyosis 86 26 1898710 (3), 7546451 (2), 2158060 (2), 2253421 (1) (see all 15)
    chondrodysplasia punctata 80.9 7 1785631 (1), 16470742 (1), 8832947 (1), 1496984 (1) (see all 5)
    multiple sulfatase deficiency 79.9 5 9336808 (3), 1687673 (1)
    kallmann syndrome 75.9 10 8276392 (2), 7806223 (1), 2328992 (1), 2339111 (1) (see all 5)
    ichthyosis vulgaris 75.8 2 11231321 (1), 17657246 (1)
    breast cancer 67.5 184 14623544 (5), 9044848 (5), 17214375 (4), 17604157 (4) (see all 85)
    albinism ocular 62.1 4 1674724 (1), 1979048 (1), 10443071 (1)
    congenital ichthyosis 59.9 4 8588575 (1), 11079322 (1)
    alopecia androgenetic 54.7 3 14571075 (1), 11886493 (1)

    Genetic Association Database (GAD): STS
    Human Genome Epidemiology (HuGE) Navigator: STS (37 documents)

    Export disorders for STS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STS gene, integrated from 10 sources (see all 462):
    (articles sorted by number of sources associating them with STS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PCR diagnosis of X-linked ichthyosis: identification of a novel mutation (E560P) of the steroid sulfatase gene. (PubMed id 10679952)1, 2, 9 Sugawara T....Fujimoto S. (Hum. Mutat. 2000)
    2. Association of the steroid sulfatase (STS) gene with attention deficit hyperactivity disorder. (PubMed id 18937300)1, 4, 9 Brookes K.J....Kent L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    3. Genes for enzymes regulating dehydroepiandrosterone sulfonation are associated with levels of dehydroepiandrosterone sulfate in polycystic ovary syndrome. (PubMed id 17426092)1, 4, 9 Goodarzi M.O....Azziz R. (J. Clin. Endocrinol. Metab. 2007)
    4. Structure of human estrone sulfatase suggests functional roles of membrane association. (PubMed id 12657638)1, 2, 9 Hernandez-Guzman F.G....Ghosh D. (J. Biol. Chem. 2003)
    5. Novel point mutations in the steroid sulfatase gene in patients with X-linked ichthyosis: transfection analysis using the mutated genes. (PubMed id 10844566)1, 2, 9 Oyama N.... Kaneko F. (J. Invest. Dermatol. 2000)
    6. Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein. (PubMed id 9252398)1, 2, 9 Alperin E.S. and Shapiro L.J. (J. Biol. Chem. 1997)
    7. Identification of point mutations in the steroid sulfatase gene of three patients with X-linked ichthyosis. (PubMed id 1539590)1, 2, 9 Basler E.... Ballabio A. (Am. J. Hum. Genet. 1992)
    8. Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. (PubMed id 20214802)1, 4 Li J....Hall P. (Breast Cancer Res. 2010)
    9. Analysis of the STS gene in 40 patients with recessive X-linked ichthyosis: a high frequency of partial deletions in a Spanish population. (PubMed id 20236202)1, 4 CaA+ueto J....GonzA!lez-Sarmiento R. (J Eur Acad Dermatol Venereol 2010)
    10. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. (PubMed id 19598235)1, 4 Chakrabarti B....Baron-Cohen S. (Autism Res 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 412 HGNC: 11425 AceView: STS Ensembl:ENSG00000101846 euGenes: HUgn412
    ECgene: STS Kegg: 412 H-InvDB: STS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STS Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=STS[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Steroid_sulfatase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STS gene:
    Search GeneIP for patents involving STS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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