STS Gene
protein-coding GIFtS: 65
GCID: GC0XP007147
|
|
steroid sulfatase (microsomal), isozyme S(Previous names: steroid sulfatase (microsomal), arylsulfatase C, isozyme...)
(Previous symbol: ARSC1)
| |
Aliases
for STS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Steroid Sulfatase (Microsomal), Isozyme S1 2 | | XLI2 5 | | ARSC11 2 3 5 | | Steroid Sulfatase (Microsomal), Arylsulfatase C, Isozyme S1 | | ARSC1 2 5 | | ES2 | | Arylsulfatase C2 3 | | Estrone Sulfatase2 | | Steryl-Sulfate Sulfohydrolase2 3 | | Steryl-Sulfatase1 | | ASC2 3 | | Steroid Sulfatase3 | | EC 3.1.6.23 8 | | EC 3.1.68 | | SSDD2 5 | | |
Export aliases for STS gene to outside databasesPrevious GC identifers: GC0XP002655 GC0XP005924 GC0XP006533 GC0XP006599 GC0XP006997 GC0XP004994 |
Summaries
for STS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for STS:
The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to estrogens during pregnancy.The encoded protein is found in the endoplasmic reticulum, where it acts as a homodimer. Mutations in this gene areknown to cause X-linked ichthyosis (XLI). (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: STS_HUMAN, P08842Function: Conversion of sulfated steroid precursors to estrogens during pregnancy
Gene Wiki entry for STS (Steroid sulfatase)
|
Genomic Views
for STS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STS gene promoter:
SRF SRF (504 AA) MyoD Nkx2-5
Other transcription factors
Search SABiosciences Chromatin IP Primers for STS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22.32 Ensembl cytogenetic band: Xp22.31 HGNC cytogenetic band: Xp22.32STS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP007147: view genomic region
(about GC identifiers)
Start:
|
7,137,472 bp from pter |
End:
|
7,272,851 bp from pter |
Size:
|
135,380 bases |
Orientation:
|
plus strand |
|
Proteins
for STS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STS_HUMAN, P08842 (See
protein sequence)Recommended Name: Steryl-sulfatase precursor Size: 583 amino acids; 65492 Da
Cofactor: Binds 1 calcium ion per subunit
Subunit: Homodimer
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
1 PDB 3D structure from  and Proteopedia  for STS:1P49 (3D)
Secondary accessions: B2RA47Explore the universe of human proteins at neXtProt for STS: NX_P08842
Post-translational modifications:
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotesand of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P08842
4/5 DME Specific Peptides for STS (P08842) (see all 5)
STS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000342.2
ENSEMBL proteins: ENSP00000217961 Reactome Protein details: P08842
Human Recombinant Protein Products:
Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14): About this table
STS for ontologies About GeneDecksing
STS Antibody Products:
Assay Products for STS: |
Protein
Domains /
Families
for STS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STS for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P08842ProtoNet protein and cluster: P08842 1 Blocks protein family: IPB000917 Sulfatase
UniProtKB/Swiss-Prot: STS_HUMAN, P08842Similarity: Belongs to the sulfatase family |
Function
for STS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STS_HUMAN, P08842Function: Conversion of sulfated steroid precursors to estrogens during pregnancyCatalytic activity: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H(2)O = 3-beta-hydroxyandrost-5-en-17-one + sulfate Genatlas biochemistry entry for STS:steroid,arylsulfatase C,X-linked,steroid sulfatase,microsomal,slow isoform,membrane bound,escaping inactivation
Enzyme Numbers (IUBMB): EC 3.1.6.21 2 EC 3.1.62
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: STS (NM_000351) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STS |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
STS for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for STS:
|
Pathways & Interactions
for STS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Estrone metabolism | | | 2 | Sphingolipid metabolism | | | 3 | Metabolism | | | 4 | PTM: gamma carboxylation, hypusine formation and arylsulfatase activation | | | 5 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for STS
2  GeneGo (Thomson Reuters) Pathways for STS
1  BioSystems Pathway for STS
5/8 
Reactome Pathways for STS (see all 8)
1  PharmGKB Pathway for STS
1 
Kegg Pathway (Kegg details for STS):
STS for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/64 Interacting proteins for STS (P088422, 3 ENSP000002179614) via UniProtKB, MINT, STRING, and/or I2D (see all 64)About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table
STS for ontologies About GeneDecksing
|
Drugs & Compounds
for STS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
STS for compounds About GeneDecksing
 Browse Tocris compounds for STS
8 HMDB Compounds for STS About this table
2 DrugBank Compounds for STS About this table
10/64 Novoseek chemical compound relationships for STS gene (see all 64) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| estrone sulfate |
95.4 |
89 |
1912612 (3), 2212823 (2), 11070351 (2), 16132094 (2) (see all 57) |
| 667-coumate |
94.3 |
15 |
10910045 (2), 16533785 (2), 19112542 (1), 17268815 (1) (see all 8) |
| estrone |
93.6 |
337 |
10215035 (9), 9044848 (8), 7696150 (7), 9654650 (7) (see all 99) |
| estrone-3-o-sulfamate |
91.5 |
13 |
9544207 (1), 10215035 (1), 11886493 (1), 12751816 (1) (see all 10) |
| 17beta-hydroxysteroid |
90.3 |
75 |
8388710 (4), 14979917 (3), 20151319 (2), 18817841 (2) (see all 41) |
| steroid |
88.7 |
881 |
17604157 (11), 11087571 (9), 16178010 (9), 15355916 (8) (see all 99) |
| estradiol sulfate |
86.9 |
4 |
16864173 (1), 19130396 (1), 14684318 (1) |
| nomegestrol acetate |
84.6 |
6 |
8918978 (3), 16080533 (1), 14670645 (1), 15767920 (1) |
| promegestone |
83.5 |
1 |
14670645 (1) |
| medrogestone |
83.5 |
1 |
14670645 (1) |
Search CenterWatch for drugs/clinical trials and news about STS
|
Transcripts
for STS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STS gene: NM_000351.4 Unigene Clusters for STS: Steroid sulfatase (microsomal), isozyme S Hs.522578 [show with all ESTs], Hs.700558 , Hs.700559 , Hs.740067 Unigene Representative Sequences: M16505, AM282554, AM282553, AM2825521 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000217961(uc004crw.2 uc011mhp.1 uc004crx.1 uc004cry.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STS (NM_000351) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STS |
Additional cDNA sequence: AM072428.1 AM072429.1 AM282552.1 FM209047.1 9 DOTS entries: DT.95269263 DT.317742 DT.121281914 DT.99948730 DT.121281959 DT.121281931 DT.95269252 DT.95269264 DT.95269265 24/200 AceView cDNA sequences (see all 200): BQ184961 BQ018515 CB852158 AI635578 D58446 AU137974 AU138166 BF197112 CB250477 BF194867 BQ018705 AU138134 BI770964 F01424 CB159619 AL545039 AL133910 AU136945 AI147055 AU158312 AI192461 BM992119 AU135888 BC075030
GeneLoc Exon Structure
|
Expression
for STS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGTGCAGG
About this image
See STS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STS
SOURCE GeneReport for Unigene clusters: Hs.522578 Hs.700558 Hs.700559 Hs.740067
SABiosciences Custom PCR Arrays for STS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat STS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STS |
Orthologs
for STS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for STS gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
STS1 |
steroid sulfatase (microsomal), isozyme S |
68.22(n)
66.85(a) |
|
418654 XM_416850.2 XP_416850.2 |
lizard
(Anolis carolinensis) |
Reptilia |
STS6-- |
-- |
63(a)39(a) |
1 ↔ 1possible ortholog |
3(117250475-117361328) GL344984.1(10385-13196) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.327282 |
Xenopus laevis transcribed sequence with weak similarity more |
75.05(n) |
|
BJ624198.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
sec61a2 |
Danio rerio, clone IMAGE5914856, mRNA, partial cds |
72.82(n) |
|
BC049491.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
ydeN6aslA6 |
acrylsulfatase-like enzyme |
18(a)17(a) |
possible ortholog1 ↔ many |
Chromosome(1578866-1580548) Chromosome(3982375-3984030) |
ENSEMBL Gene Tree for STS (if available)
TreeFam Gene Tree for STS (if available) |
Paralogs
for STS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STS gene
- ARSF2 ARSJ2 ARSI2 ARSG2 ARSA2 ARSH2 ARSB2 GALNS2
- ARSE2 ARSD2
5 SIMAP similar genes for STS using alignment to 5 protein entries: STS_HUMAN (see all proteins):ARSE ARSH ARSD ARSF IDS
STS for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for STS
PGOHUM00000233967
|
Genomic Variants
for STS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STS (7137472 - 7272851 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for STS
2 CNVs: 4143 31544
Human Gene Mutation Database (HGMD): STS
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STS |
|
Disorders
/ Diseases
for STS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STS for disorders About GeneDecksing
OMIM gene information: 300747
OMIM disorders: 308100
UniProtKB/Swiss-Prot: STS_HUMAN, P08842
Defects in STS are the cause of ichthyosis X-linked (IXL) [MIM:308100]. Ichthyosis X-linked is akeratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeksafter birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities,trunk, and buttocks
20/64  diseases for STS (see all 64): About MalaCardsx-linked ichthyosis smith-lemli-opitz syndrome ichthyosis mental retardation, x-linked
periventricular nodular heterotopia congenital ichthyosiform erythroderma chondrodysplasia punctata end stage renal failure
adrenocorticotropic hormone deficiency attention deficit hyperactivity disorder ichthyosis vulgaris metachromatic leukodystrophy
short stature clear cell adenocarcinoma anencephaly kallmann syndrome
ovarian clear cell adenocarcinoma ocular albinism heterotopia leukodystrophy
2 diseases from the University of Copenhagen DISEASES database for STS:X-linked ichthyosis Schneckenbecken dysplasia 10/47 Novoseek disease relationships for STS gene (see all 47) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ichthyosis x-linked |
97.5 |
98 |
11231321 (7), 10692123 (5), 16196306 (4), 2080119 (2) (see all 48) |
| ichthyosis |
86 |
26 |
1898710 (3), 7546451 (2), 2158060 (2), 2253421 (1) (see all 15) |
| chondrodysplasia punctata |
80.9 |
7 |
1785631 (1), 16470742 (1), 8832947 (1), 1496984 (1) (see all 5) |
| multiple sulfatase deficiency |
79.9 |
5 |
9336808 (3), 1687673 (1) |
| kallmann syndrome |
75.9 |
10 |
8276392 (2), 7806223 (1), 2328992 (1), 2339111 (1) (see all 5) |
| ichthyosis vulgaris |
75.8 |
2 |
11231321 (1), 17657246 (1) |
| breast cancer |
67.5 |
184 |
14623544 (5), 9044848 (5), 17214375 (4), 17604157 (4) (see all 85) |
| albinism ocular |
62.1 |
4 |
1674724 (1), 1979048 (1), 10443071 (1) |
| congenital ichthyosis |
59.9 |
4 |
8588575 (1), 11079322 (1) |
| alopecia androgenetic |
54.7 |
3 |
14571075 (1), 11886493 (1) |
Human Genome Epidemiology (HuGE) Navigator: STS (37 documents)
Export disorders for STS gene to outside databases
|
Publications
for STS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STS gene, integrated from 9 sources (see all 453):
(articles sorted by number of sources associating them with STS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- PCR diagnosis of X-linked ichthyosis: identification of a novel mutation (E560P) of the steroid sulfatase gene. (PubMed id 10679952)1, 2, 9 Sugawara T....Fujimoto S. (2000)
- Structure of human estrone sulfatase suggests functional roles of membrane association. (PubMed id 12657638)1, 2, 9 Hernandez-Guzman F.G....Ghosh D. (2003)
- Novel point mutations in the steroid sulfatase gene in patients with X-linked ichthyosis: transfection analysis using the mutated genes. (PubMed id 10844566)1, 2, 9 Oyama N.... Kaneko F. (2000)
- Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein. (PubMed id 9252398)1, 2, 9 Alperin E.S. and Shapiro L.J. (1997)
- Identification of point mutations in the steroid sulfatase gene of three patients with X-linked ichthyosis. (PubMed id 1539590)1, 2, 9 Basler E.... Ballabio A. (1992)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of rat and human steroid sulfatases. (PubMed id 2765556)1, 2 Kawano J....Aikawa E. (1989)
- Cloning and expression of human steroid-sulfatase. Membrane topology, glycosylation, and subcellular distribution in BHK-21 cells. (PubMed id 2668275)1, 2 Stein C.... von Figura K. (1989)
- The human X-linked steroid sulfatase gene and a Y-encoded pseudogene: evidence for an inversion of the Y chromosome during primate evolution. (PubMed id 3203382)1, 2 Yen P.H.... Shapiro L.J. (1988)
- Cloning and expression of steroid sulfatase cDNA and the frequent occurrence of deletions in STS deficiency: implications for X-Y interchange. (PubMed id 3032454)1, 2 Yen P.H....Shapiro L.J. (1987)
|
External Searches for STS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STS | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/STS | | Wikipedia | http://en.wikipedia.org/wiki/Steroid_sulfatase |
|
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About This Section
| Patent Information for STS gene:
Search GeneIP for patents involving STS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for STS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for STS | | OriGene shRNA RFP for STS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STS | | | OriGene Protein Over-expression Lysate for STS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STS | | OriGene 3'-UTR Clone for STS | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for STS | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for STS | | OriGene Custom Protein Services for STS | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STS |
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| | | | Search Tocris compounds for STS |
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 | | | STS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STS |
|  |  |  | | | | ThermoFisher Antibodies for STS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STS |
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