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STS Gene

protein-coding GIFtS: 62

GC0XP007147

steroid sulfatase (microsomal), isozyme S
(Previous names: steroid sulfatase (microsomal), arylsulfatase C, isozyme S )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ARSC1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ARSC ^¹, ², ⁵
ARSC1 ^², ³, ⁵
ASC ^², ³
EC 3.1.6.2 ^³
ES ^²
OTTHUMP00000022868 ^²
SSDD ^², ⁵
XLI ^², ⁵
steryl-sulfatase ^²

Descriptions
Arylsulfatase C ^², ³
Steroid sulfatase ^³
Steryl-sulfate sulfohydrolase ^², ³
estrone sulfatase ^²
steroid sulfatase (microsomal), arylsulfatase C, isozyme S ^¹
steroid sulfatase (microsomal), isozyme S ^²

External Ids
HGNC: 11425¹
Entrez Gene: 412²
UniProtKB: P08842³
Ensembl: ENSG00000101846⁷

Search outside databases for aliases for STS gene

Previous GC identifers: GC0XP002655 GC0XP005924 GC0XP006533 GC0XP006599 GC0XP006997

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for STS:

The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to

estrogens during pregnancy. The encoded protein is found in the endoplasmic reticulum, where it

acts as a homodimer. Mutations in this gene are known to cause X-linked ichthyosis (XLI).

[provided by RefSeq]

UniProtKB/Swiss-Prot: STS_HUMAN, P08842

Function: Conversion of sulfated steroid precursors to estrogens during pregnancy

Gene Wiki entry for STS (Steroid_sulfatase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the STS gene

Entrez Gene cytogenetic band: Xp22.32 Ensembl cytogenetic band: Xp22.31 HGNC cytogenetic band: Xp22.32

STS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP007147: (about GC identifiers)

Start:	7,147,472 bp from pter
End:	7,282,682 bp from pter
Size:	135,211 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011757.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: STS_HUMAN, P08842 (See protein sequence)

Recommended Name: Steryl-sulfatase precursor

Size: 583 amino acids; 65492 Da

Cofactor: Binds 1 calcium ion per subunit

Subunit: Homodimer

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

1P49 (3D)

Secondary accessions: B2RA47

Post-translational modifications:

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine

residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity

(By similarity)¹

REFSEQ proteins: NP_000342.2

ENSEMBL proteins:

ENSP00000217961

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Steroid sulfatase)
	Human Recombinant Proteins from Abnova (STS)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	2668275
GO:0005764	lysosome	TAS	2668275
GO:0005768	endosome	TAS	2668275
GO:0005783	endoplasmic reticulum	TAS	2668275
GO:0005789	endoplasmic reticulum membrane	IEA	--

About this table

Antibodies for STS:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for STS
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Steroid sulfatase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (STS)
	Novus Biologicals Antibodies for STS

Assays for STS:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08842

ProtoNet protein and cluster: P08842

1 Blocks protein family: IPB000917 Sulfatase

UniProtKB/Swiss-Prot: STS_HUMAN, P08842

Similarity: Belongs to the sulfatase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (STS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (STS)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000351

Applied Biosystems Silencer® siRNAs for STS

Sigma-Aldrich siRNA and siRNA Panels for STS

Sigma-Aldrich shRNA for STS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for STS
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000351
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000351
untagged cDNA clones in CMV expression vector (see all 2): NM_000351

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000351

UniProtKB/Swiss-Prot: STS_HUMAN, P08842

Function: Conversion of sulfated steroid precursors to estrogens during pregnancy

Catalytic activity: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H(2)O =

3-beta-hydroxyandrost-5-en-17-one + sulfate

Enzyme Number (IUBMB): EC 3.1.6.2

Genatlas biochemistry entry for STS:

steroid,arylsulfatase C,X-linked,steroid sulfatase,microsomal,slow isoform,membrane bound,escaping

inactivation

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004773	steryl-sulfatase activity	TAS	2668275
GO:0005509	calcium ion binding	IEA	--
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for STS (Your Favorite Gene powered by Ingenuity)

Androgen and Estrogen Metabolism

GeneDecks STS for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for STS

5/66 Interacting proteins for STS (P08842² ENSP00000217961³) via UniProtKB, MINT, and/or STRING (see all 66 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CYP19A1	P11511², ENSP00000260433³	MINT-4054731 STRING (score=.818)
A2M	P01023²	MINT-4054731
ACTB	P60709²	MINT-4054731
ALPP	P05187²	MINT-4054731
APOD	P05090²	MINT-4054731

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	IEA	--
GO:0006706	steroid catabolic process	TAS	6957717
GO:0007565	female pregnancy	IEA	--
GO:0008152	metabolic process	IEA	--
GO:0008544	epidermis development	TAS	9252398

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for STS:

Inhibitor

Browse Tocris compounds for STS
10/40 Novoseek chemical compound relationships for STS gene (see all 40 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
667-coumate	94.43	15	10910045 (2), 16533785 (2), 19112542 (1), 17268815 (1) (see all 8)
17beta-hydroxysteroid	89.64	67	8388710 (4), 14979917 (3), 8918978 (2), 17316633 (2) (see all 38)
steroid	88.59	849	17604157 (11), 11087571 (9), 16178010 (9), 15355916 (8) (see all 99)
estradiol sulfate	87.52	4	16864173 (1), 19130396 (1), 14684318 (1)
promegestone	83.75	1	14670645 (1)
4-methylumbelliferyl sulfate	81.42	1	11177574 (1)
dehydroepiandrosterone sulfate	79.91	51	11070351 (3), 17426092 (3), 10736251 (3), 11087571 (2) (see all 27)
dhea	77.38	50	15152080 (2), 16399355 (1), 18937300 (1), 8603401 (1) (see all 22)
estradiol	74.60	37	11087571 (2), 10576217 (2), 17481887 (2), 8388710 (1) (see all 32)
steroidal	73.48	27	9054565 (2), 10215035 (2), 9654650 (2), 12231117 (2) (see all 14)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (STS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (STS)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000351

Sigma-Aldrich siRNA and siRNA Panels for STS

Sigma-Aldrich shRNA for STS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000351

REFSEQ mRNAs for STS gene:

NM_000351.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000351

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000351
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000351
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000351

Additional cDNA sequence: AM282553.1

9 DOTS entries:

DT.95269263 DT.317742 DT.121281914 DT.99948730 DT.121281959 DT.95269264 DT.121281931 DT.95269265

DT.95269252

24/200 AceView cDNA sequences (see all 200 ):

AI147055 AL133910 AU139261 CB159619 BM763170 BQ018515 AU138134 AU135888

AU137974 AU138166 BF197112 BI770964 BQ018705 AI635578 BC075030 CR618192

F01424 BM992119 M17591 CB250477 AI192461 AA975782 CB852158 D58446

highest scoring ESTs for STS:

M16505 AA214587 AA410541 AA480919 AA630755 AA676610 AA702668 AA741153 AA884381 AI015899

Unigene Clusters for STS:

Steroid sulfatase (microsomal), isozyme S

Hs.522578 [show with all ESTs], Hs.700558 , Hs.700559

Unigene Representative Sequences: M16505, AM282554, AM282553

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000217961

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

STS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for STS

¹ / ² / ³

9 probe-sets matching STS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38034_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M16505	1.00	1.00	1.00	1
203769_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000351	0.60	1.00	0.82	1
203767_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI122754	0.60	1.00	0.82	1
203768_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU138166	0.80	1.00	0.91	1
203770_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	J04964	0.80	1.00	0.91	1
203769_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203767_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203768_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203770_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks STS for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.522578 Hs.700558 Hs.700559
Expression variation in blood from EXPOLDB for STS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for STS gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	STS¹	--	steroid sulfatase (microsomal), isozyme S	79.07(n) 78.72(a)	491727 XM_548847.2 XP_548847.2
chimpanzee (Pan troglodytes)	STS¹	--	steroid sulfatase (microsomal), isozyme S	99.48(n) 99.14(a)	465478 XM_520918.2 XP_520918.2
cow (Bos taurus)	STS¹	--	steroid sulfatase (microsomal), isozyme S	76.92(n) 78.15(a)	509206 NM_001075394.1 NP_001068862.1
rat (Rattus norvegicus)	Sts¹	--	steroid sulfatase	63.53(n) 64.89(a)	24800 NM_012661.1 NP_036793.1
mouse (Mus musculus)	Sts⁵	XY (75.00 cM)	steroid sulfatase	--	U37545

About this table Species with no ortholog for STS

ENSEMBL Gene Tree for STS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for STS gene

ARSF² ARSE² ARSH² ARSD²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/467 NCBI SNPs in STS are shown (see all 467 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 88)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1131289^1,2	A,C,F,H	7280996(+)	`CACACG/ACAAAA`	1	--	ut3¹ ese³		4	EU EA WA	418
	rs10521600^1,2	C,F,H	7279320(-)	`GTGTAT/CAGATC`	1	--	ut3¹ ese³		16	NS EU EA WA NA	858
	rs16984468^1,2	F,H	7282791(+)	`TCTGGA/TAAGGA`	1	--	ng3¹ ese³ trp³		7	NA EU EA WA	534
	rs5933863^1,2	F,H	7280694(+)	`ACAAAG/ACATCT`	1	--	ut3¹ ese³		4	EU EA WA	420
--	rs13648^1,2	C,F	7282225(+)	`ggcctA/Gccttc`	1	--	ut3¹ ese³		6	MN EA NA	588
	rs1000900^1,2	A,C,F,H,O	7162113(-)	`GGCAGC/TAGATG`	1	--	int¹		14	NA EA EU WA	925
	rs2024159^1,2	A,C,F,H,O	7176212(-)	`TGACAG/TTTTGC`	1	--	int¹		12	EU EA WA NA	836
--	rs5933793^1,2	A,C,F,H	7160497(+)	`TTGCAG/ATTTGG`	1	--	int¹		7	EU EA WA NA	533
	rs5979364^1,2	A,C,F,H	7254205(+)	`AGGCCG/ACTGCT`	1	--	int¹		4	EU EA WA	418
	rs5934770^1,2	A,C,F,H	7179546(+)	`CACATG/TCCAGT`	1	--	int¹		8	EU EA WA	630

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HapMap Linkage Disequilibrium images for STS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300747 disorders: 308100

UniProtKB/Swiss-Prot: STS_HUMAN, P08842

Defects in STS are the cause of ichthyosis X-linked (IXL) [MIM:308100]. Ichthyosis

X-linked is a keratinization disorder manifesting with mild erythroderma and generalized

exfoliation of the skin within a few weeks after birth. Affected boys later develop large,

polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks

10/47 Novoseek disease relationships for STS gene (see all 47 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ichthyosis x-linked	97.41	98	11231321 (7), 10692123 (5), 16196306 (4), 2080119 (2) (see all 48)
ichthyosis	85.15	26	1898710 (3), 7546451 (2), 2158060 (2), 2253421 (1) (see all 15)
chondrodysplasia punctata	81.52	7	1785631 (1), 8832947 (1), 16470742 (1), 1496984 (1) (see all 5)
multiple sulfatase deficiency	80.74	5	9336808 (3), 1687673 (1)
kallmann syndrome	76.77	10	8276392 (2), 7806223 (1), 2328992 (1), 2339111 (1) (see all 5)
ichthyosis vulgaris	74.26	2	11231321 (1), 17657246 (1)
breast cancer	67.11	170	14623544 (5), 9044848 (5), 17214375 (4), 17604157 (4) (see all 81)
albinism ocular	62.94	4	1674724 (1), 1979048 (1), 10443071 (1)
congenital ichthyosis	61.24	4	8588575 (1), 11079322 (1)
alopecia androgenetic	55.89	3	14571075 (1), 11886493 (1)

About this table

Human Gene Mutation Database: STS
Human Genome Epidemiology Navigator: STS (20 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/392 PubMed articles for STS gene (see all 392 ):

PCR diagnosis of X-linked ichthyosis: identification of a novel mutation (E560P) of the steroid sulfatase gene. (PubMed id 10679952)^{1, 3, 4} Sugawara T....Fujimoto S. (2000)
Structure of human estrone sulfatase suggests functional roles of membrane association. (PubMed id 12657638)^{1, 3, 4} Hernandez-Guzman F.G....Ghosh D. (2003)
Novel point mutations in the steroid sulfatase gene in patients with X-linked ichthyosis: transfection analysis using the mutated genes. (PubMed id 10844566)^{1, 3, 4} Oyama N.... Kaneko F. (2000)
Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein. (PubMed id 9252398)^{1, 3, 4} Alperin E.S. and Shapiro L.J. (1997)
Identification of point mutations in the steroid sulfatase gene of three patients with X-linked ichthyosis. (PubMed id 1539590)^{1, 3, 4} Basler E.... Ballabio A. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Characterization of rat and human steroid sulfatases. (PubMed id 2765556)^{3, 4} Kawano J....Aikawa E. (1989)
Cloning and expression of human steroid-sulfatase. Membrane topology, glycosylation, and subcellular distribution in BHK-21 cells. (PubMed id 2668275)^{3, 4} Stein C.... von Figura K. (1989)
The human X-linked steroid sulfatase gene and a Y-encoded pseudogene: evidence for an inversion of the Y chromosome during primate evolution. (PubMed id 3203382)^{3, 4} Yen P.H.... Shapiro L.J. (1988)
Cloning and expression of steroid sulfatase cDNA and the frequent occurrence of deletions in STS deficiency: implications for X-Y interchange. (PubMed id 3032454)^{3, 4} Yen P.H....Shapiro L.J. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 412	HGNC: 11425	AceView: STS	Ensembl:ENSG00000101846	euGenes: HUgn412
ECgene: STS	H-InvDB: STS

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=STS
Wikipedia	http://en.wikipedia.org/wiki/Steroid_sulfatase

Licensable Technologies for STS
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for STS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for STS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for STS		Antibodies for STS
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for STS		Small molecules for STS
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (STS)
	Antibodies (STS)
	Chimera RNAi (STS)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Antibodies for STS

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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STS Gene at Home site.
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STS Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for STS

Summaries
for STS

Genomic Location
for STS

Proteins
for STS

Protein Domains/
Families
for STS

Gene Function
for STS

Pathways & Interactions
for STS

Drugs & Compounds
for STS

Transcripts
for STS

Expression
for STS

Orthologs
for STS

Paralogs
for STS

SNPs/Variants
for STS

Disorders & Mutations
for STS

Medical News
for STS

Publications
for STS

Search for STS

Genome Databases showing STS

Other Databases showing STS

Specialized Databases showing STS

Licensable Technologies
for STS

Services
for STS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

STS Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor STS

Summariesfor STS

Genomic Locationfor STS

Proteinsfor STS

Protein Domains/Familiesfor STS

Gene Functionfor STS

Pathways & Interactionsfor STS

Drugs & Compoundsfor STS

Transcriptsfor STS

Expression for STS

Orthologsfor STS

Paralogsfor STS

SNPs/Variantsfor STS

Disorders & Mutationsfor STS

Medical Newsfor STS

Publicationsfor STS

Search for STS

Genome Databases showing STS

Other Databases showing STS

Specialized Databases showing STS

Licensable Technologiesfor STS

Servicesfor STS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for STS

Summaries
for STS

Genomic Location
for STS

Proteins
for STS

Protein Domains/
Families
for STS

Gene Function
for STS

Pathways & Interactions
for STS

Drugs & Compounds
for STS

Transcripts
for STS

Expression
for STS

Orthologs
for STS

Paralogs
for STS

SNPs/Variants
for STS

Disorders & Mutations
for STS

Medical News
for STS

Publications
for STS

Licensable Technologies
for STS

Services
for STS