Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



STRN4 Gene

protein-coding   GIFtS: 52
GCID: GC19M047222

Striatin, Calmodulin Binding Protein 4

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Striatin, Calmodulin Binding Protein 41 2
ZIN2 3 5
striatin-42
zinedin2
Zinedin3

External Ids:    HGNC: 157211   Entrez Gene: 298882   Ensembl: ENSG000000903727   OMIM: 6147675   UniProtKB: Q9NRL33   

Export aliases for STRN4 gene to outside databases

Previous GC identifers: GC19M047614 GC19M051898 GC19M051914 GC19M043647


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for STRN4 Gene:
STRN4 (striatin, calmodulin binding protein 4) is a protein-coding gene. GO annotations related to this gene include calmodulin binding and protein phosphatase 2A binding. An important paralog of this gene is STRN.

UniProtKB/Swiss-Prot: STRN4_HUMAN, Q9NRL3
Function: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein

Gene Wiki entry for STRN4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STRN4 gene promoter:
         E2F-4   E2F-3a   E2F-5   Elk-1   AP-1   HTF   E2F-2   E2F   E2F-1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTRN4 promoter sequence
   Search Chromatin IP Primers for STRN4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STRN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

STRN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STRN4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M047222:  view genomic region     (about GC identifiers)

Start:
47,222,764 bp from pter      End:
47,250,251 bp from pter
Size:
27,488 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: STRN4_HUMAN, Q9NRL3 (See protein sequence)
Recommended Name: Striatin-4  
Size: 753 amino acids; 80596 Da
Subunit: Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN4. Activation
of glutamate receptors weakens the interaction with CTTNBP2 (By similarity). Interacts with CTTNBP2NL
Miscellaneous: The name 'Zinedin' probably originates from the name of the famous soccer player from Marseille
(Zinedine Zidane)
Secondary accessions: Q8NE53

Explore the universe of human proteins at neXtProt for STRN4: NX_Q9NRL3

Explore proteomics data for STRN4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys431
  • Modification sites at PhosphoSitePlus

  • See STRN4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001034966.1  NP_037535.2  

    ENSEMBL proteins: 
     ENSP00000263280   ENSP00000375777   ENSP00000440901   ENSP00000472938   ENSP00000470634  
     ENSP00000473446   ENSP00000473607   ENSP00000471499   ENSP00000471354   ENSP00000470040  
     ENSP00000472429   ENSP00000469279  

    STRN4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for STRN4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for STRN4
    GenScript Custom Purified and Recombinant Proteins Services for STRN4
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for STRN4 

     
    antibodies-online proteins for STRN4 (2 products) 

     
    antibodies-online peptides for STRN4

    STRN4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for STRN4
    Novus Biologicals STRN4 Antibody
    Abcam antibodies for STRN4
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for STRN4
    antibodies-online antibodies for STRN4 (45 products) 

    STRN4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STRN4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STRN4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for STRN4 
    antibodies-online kits for STRN4 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR013258 Striatin_N

    Graphical View of Domain Structure for InterPro Entry Q9NRL3

    ProtoNet protein and cluster: Q9NRL3

    UniProtKB/Swiss-Prot: STRN4_HUMAN, Q9NRL3
    Similarity: Belongs to the WD repeat striatin family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with STRN4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STRN4_HUMAN, Q9NRL3
    Function: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005516calmodulin binding NAS10748158
    GO:0019904protein domain specific binding ----
    GO:0032403protein complex binding IDA18782753
    GO:0051721protein phosphatase 2A binding IDA18782753
         
    Find genes that share ontologies with STRN4           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for STRN4

    miRNA
    Products:
        
    miRTarBase miRNAs that target STRN4:
    hsa-mir-18a-3p (MIRT040848)

    Block miRNA regulation of human, mouse, rat STRN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STRN4 (see all 27):
    hsa-miR-485-5p hsa-miR-875-3p hsa-miR-128 hsa-miR-605 hsa-miR-29c hsa-miR-29a hsa-miR-340 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidSTRN4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STRN4
    Predesigned siRNA for gene silencing in human, mouse, rat STRN4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STRN4

    Clone
    Products:
         
    OriGene clones in human, mouse for STRN4 (see all 13)
    OriGene ORF clones in mouse, rat for STRN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): STRN4 (NM_013403)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRN4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STRN4
    Browse ESI BIO Cell Lines and PureStem Progenitors for STRN4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRN4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    STRN4_HUMAN, Q9NRL3: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Cell
    projection, dendritic spine (By similarity). Note=CTTNBP2-binding may regulate dendritic spine distribution (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159colocalizes with protein phosphatase type 2A complex IDA18782753
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--
    GO:0043197dendritic spine IEA--
    GO:0043234protein complex ----

    Find genes that share ontologies with STRN4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STRN4
    Interactions:

        GeneGlobe Interaction Network for STRN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STRN4 (Q9NRL31, 2, 3 ENSP000003757774) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX39BQ138382, 3MINT-65604 I2D: score=5 
    ENSG00000215425Q138382, 3MINT-65604 I2D: score=5 
    ENSG00000225073Q138382, 3MINT-65604 I2D: score=5 
    ENSG00000225859Q138382, 3MINT-65604 I2D: score=5 
    ENSG00000229496Q138382, 3MINT-65604 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with STRN4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STRN4

    1 HMDB Compound for STRN4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for STRN4 gene (2 alternative transcripts): 
    NM_001039877.1  NM_013403.2  

    Unigene Cluster for STRN4:

    Striatin, calmodulin binding protein 4
    Hs.631590  [show with all ESTs]
    Unigene Representative Sequence: NM_001039877
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000263280(uc002pfl.3 uc010xyf.2) ENST00000391910(uc002pfm.3)
    ENST00000601869 ENST00000594581 ENST00000539396 ENST00000600615 ENST00000595357
    ENST00000594287 ENST00000601631 ENST00000598074 ENST00000594357 ENST00000600358
    ENST00000435164(uc010xyg.1) ENST00000602223 ENST00000599231 ENST00000594847
    ENST00000596016 ENST00000602397
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STRN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STRN4 (see all 27):
    hsa-miR-485-5p hsa-miR-875-3p hsa-miR-128 hsa-miR-605 hsa-miR-29c hsa-miR-29a hsa-miR-340 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidSTRN4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STRN4
    Predesigned siRNA for gene silencing in human, mouse, rat STRN4
    Clone
    Products:
         
    OriGene clones in human, mouse for STRN4 (see all 13)
    OriGene ORF clones in mouse, rat for STRN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): STRN4 (NM_013403)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRN4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STRN4
    OriGene qSTAR qPCR primer pairs in human, mouse for STRN4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STRN4
      QuantiTect SYBR Green Assays in human, mouse, rat STRN4
      QuantiFast Probe-based Assays in human, mouse, rat STRN4

    Additional mRNA sequence: 

    AB209003.1 AF212940.1 AK055312.1 AK056294.1 AK092913.1 AK225493.1 AK297637.1 AK298804.1 
    AK308813.1 BC004910.2 BC014278.2 BC034604.1 CR749727.1 FJ423752.1 

    23 DOTS entries:

    DT.100817638  DT.454107  DT.100705353  DT.95234424  DT.121480122  DT.100817639  DT.100817636  DT.121480227 
    DT.100759016  DT.100817637  DT.100029768  DT.95069183  DT.121480023  DT.121480124  DT.95220711  DT.121480026 
    DT.121480066  DT.40133359  DT.75143350  DT.91805269  DT.91913202  DT.95220724  DT.121480083 

    Selected AceView cDNA sequences (see all 321):

    CD624997 BE408140 CK823396 BM479817 BU197205 AI014728 BQ682564 AL538242 
    BI522649 BM909916 BQ707665 CD672547 BU554140 AA383536 AI014501 AI650858 
    AW593838 CR622498 BQ428547 AW005318 CA448267 BQ898168 AA327080 BU857771 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STRN4 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a ·
    SP1:                                -                       -     -     -     -                       -     -                             -     -           -   
    SP2:                                -                       -     -     -     -                       -     -                             -     -               
    SP3:                                                                                                                                                            
    SP4:                    -           -                       -     -     -     -                                                                                 
    SP5:                    -           -                       -                                                                                                   

    ExUns: 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23
    SP1:        -                                                                     
    SP2:        -                                                                     
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for STRN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    STRN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGCCGCCCC
    STRN4 Expression
    About this image

    STRN4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STRN4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631590
        Custom PCR Arrays for STRN4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for STRN4
    OriGene qSTAR qPCR primer pairs in human, mouse for STRN4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STRN4
    QuantiTect SYBR Green Assays in human, mouse, rat STRN4
    QuantiFast Probe-based Assays in human, mouse, rat STRN4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for STRN4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Strn41 , 5 striatin, calmodulin binding protein 41, 5 87.78(n)1
    95.09(a)1
      7 (9.15 cM)5
    973871  NM_133789.31  NP_598550.21 
     168158895 
    lizard
    (Anolis carolinensis)
    Reptilia STRN46
    striatin, calmodulin binding protein 4
    77(a)
    1 ↔ 1
    GL343566.1(372077-403050)
    zebrafish
    (Danio rerio)
    Actinopterygii strn41 striatin, calmodulin binding protein 4 65.25(n)
    65.2(a)
      562780  XM_686154.6  XP_691246.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COP16
    Alpha subunit of COPI vesicle coatomer complex, wh...
    8(a)
    1 → many
    IV(194571-198176) YDL145C


    ENSEMBL Gene Tree for STRN4 (if available)
    TreeFam Gene Tree for STRN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for STRN4 gene
    STRN2  STRN32  COPA2  
    6 SIMAP similar genes for STRN4 using alignment to 12 protein entries:     STRN4_HUMAN (see all proteins):
    WDR18    STRN3    LOC729862    STRN    WSB1    COPB2

    Find genes that share paralogs with STRN4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for STRN4 (see all 651)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1164045601,2
    F--47222402(+) GGGATG/AGGAAC 2 -- int11Minor allele frequency- A:0.04WA 118
    rs1812327391,2
    C--47222476(+) CAGGCA/GGGGCT 2 -- int10--------
    rs1405543831,2
    --47222592(+) CTCCAA/CTTCTC 2 -- int10--------
    rs1158303001,2
    F--47222653(+) CTACCA/GCAAAA 2 -- int11Minor allele frequency- G:0.03WA 118
    rs750452031,2
    F--47222711(+) AGAGCC/TGGTCA 2 -- int11Minor allele frequency- T:0.02WA 118
    rs1427996851,2
    --47222801(+) TTTCAC/TATACA 2 -- ut310--------
    rs31782231,2
    C--47222872(-) TGGTTC/TTACCC 2 -- ut313Minor allele frequency- T:0.00MN NA 188
    rs773749031,2
    C,F--47222966(+) GGGGCG/AGCGCC 2 -- ut311Minor allele frequency- A:0.04WA 118
    rs1474401231,2
    --47223137(+) CTGGCC/TTGGAA 2 -- ut310--------
    rs801544551,2
    C,F--47223164(+) GGAAAG/ACAGTG 2 -- ut311Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for STRN4 (47222764 - 47250251 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for STRN4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833850CNV Loss17160897
    dgv3961n71CNV Loss21882294
    nsv912189CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STRN4
    DNA2.0 Custom Variant and Variant Library Synthesis for STRN4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614767    OMIM disorders: --


    Find genes that share disorders with STRN4           About GenesLikeMe

    Genetic Association Database (GAD): STRN4
    Human Genome Epidemiology (HuGE) Navigator: STRN4 (4 documents)

    Export disorders for STRN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for STRN4 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with STRN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. (PubMed id 10748158)1, 2, 3 Castets F....Monneron A. (J. Biol. Chem. 2000)
    2. Genetic susceptibility variants for chronic lymphocytic leukemia. (PubMed id 20332261)1, 4 Slager S.L....Cerhan J.R. (amp 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PubMed id 18782753)1, 2 Goudreault M.... Gingras A.C. (Mol. Cell. Proteomics 2009)
    5. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. (PubMed id 18758461)1, 4 Di Bernardo M.C....Houlston R.S. (Nat. Genet. 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction. (PubMed id 23277359)1 Tran H....Polakis P. (J. Biol. Chem. 2013)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29888 HGNC: 15721 AceView: STRN4 Ensembl:ENSG00000090372 euGenes: HUgn29888
    ECgene: STRN4 H-InvDB: STRN4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for STRN4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for STRN4 gene:
    Search GeneIP for patents involving STRN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for STRN4  
     OriGene qPCR primer pairs and template standards for STRN4   OriGene Protein Over-expression Lysate for STRN4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for STRN4  
     OriGene qSTAR qPCR primer pairs in human, mouse for STRN4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for STRN4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for STRN4   OriGene Custom Protein Services for STRN4  

     
     
     Block miRNA regulation of human, mouse, rat STRN4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing STRN4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STRN4 Predesigned siRNA for gene silencing in human, mouse, rat STRN4
     QuantiFast Probe-based Assays in human, mouse, rat STRN4 QuantiTect SYBR Green Assays in human, mouse, rat STRN4
     Custom PCR Arrays for STRN4 Search Chromatin IP Primers for STRN4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STRN4  GeneGlobe Interaction Network for STRN4
     Regulatory tfbs in STRN4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for STRN4 GenScript cDNA clones with any tag delivered in your preferred vector for STRN4
     GenScript Custom Assay Services for STRN4 GenScript Custom overexpressing Cell Line Services for STRN4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for STRN4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     STRN4 antibodies
     Antibodies for STRN4
     See all of Abcam's Antibodies, Kits and Proteins for STRN4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for STRN4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRN4
     SwitchGear 3'UTR luciferase reporter plasmids for STRN4
     SwitchGear Promoter luciferase reporter plasmids for STRN4
     Search ThermoFisher Antibodies for STRN4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRN4
     Browse compounds at ApexBio
     Search Addgene for plasmids for STRN4
      Search eBioscience for proteins for STRN4
      Search eBioscience for elisas for STRN4
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for STRN4
     antibodies-online antibodies for STRN4 (45 products)
     antibodies-online kits for STRN4 (4 products)
     antibodies-online peptides for STRN4
     antibodies-online proteins for STRN4 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      STRN4 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4