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Aliases for STRN4 Gene

Aliases for STRN4 Gene

  • Striatin 4 2 3 5
  • Zinedin 2 3 4
  • Protein Phosphatase 2 Regulatory Subunit Bgamma 2 3
  • Striatin, Calmodulin Binding Protein 4 2 3
  • ZIN 3 4
  • Striatin-4 3
  • PPP2R6C 3

External Ids for STRN4 Gene

Previous GeneCards Identifiers for STRN4 Gene

  • GC19M047614
  • GC19M051898
  • GC19M051914
  • GC19M047222
  • GC19M043647

Summaries for STRN4 Gene

GeneCards Summary for STRN4 Gene

STRN4 (Striatin 4) is a Protein Coding gene. GO annotations related to this gene include protein domain specific binding and calmodulin binding. An important paralog of this gene is STRN3.

UniProtKB/Swiss-Prot for STRN4 Gene

  • Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

Gene Wiki entry for STRN4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRN4 Gene

Genomics for STRN4 Gene

Regulatory Elements for STRN4 Gene

Enhancers for STRN4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F046713 1.1 FANTOM5 Ensembl ENCODE 37.1 +29.1 29083 9.8 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF143 FOS PAF1 FKRP STRN4 PRKD2 ZC3H4 FBXO46 CCDC61 ENSG00000269148 GLTSCR1 CCDC9 GC19M046720
GH19F046696 0.9 ENCODE 26.8 +49.3 49315 1.6 HDGF HDAC1 ATF1 ZBTB40 SCRT2 CREM EGR2 SMARCA5 SP3 ZBTB2 FKRP STRN4 AP2S1 PRKD2 RN7SL364P MIR320E
GH19F046745 0.8 ENCODE 26.7 +0.7 656 2.5 TBP ZNF76 SIN3A FEZF1 BMI1 ZEB1 YY1 ZNF121 GLIS2 ZNF366 STRN4 CCDC61 ENSG00000269148 CCDC9 ZC3H4 SLC1A5 PRKD2 FKRP GLTSCR1
GH19F046727 1.1 FANTOM5 Ensembl ENCODE 25.9 +15.6 15636 6.9 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ZNF302 ZC3H4 GLTSCR1 ENSG00000268810 CCDC61 PRKD2 STRN4 ENSG00000259605 ENSG00000268746 MIR320E GNG8
GH19F046754 0.8 Ensembl ENCODE 25 -8.4 -8394 0.8 KLF1 ZMYM3 NR3C1 ZNF24 PRDM1 NR2F2 STRN4 PRKD2 PIR50916
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around STRN4 on UCSC Golden Path with GeneCards custom track

Promoters for STRN4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044903 894 1801 TBP ZNF76 SIN3A BMI1 ZEB1 YY1 EGR2 SP3 ZBTB11 ZEB2

Genomic Location for STRN4 Gene

Chromosome:
19
Start:
46,719,507 bp from pter
End:
46,746,994 bp from pter
Size:
27,488 bases
Orientation:
Minus strand

Genomic View for STRN4 Gene

Genes around STRN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRN4 Gene

Proteins for STRN4 Gene

  • Protein details for STRN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRL3-STRN4_HUMAN
    Recommended name:
    Striatin-4
    Protein Accession:
    Q9NRL3
    Secondary Accessions:
    • A0A024R0V2
    • B4DQH7
    • F8VYA6
    • Q8NE53

    Protein attributes for STRN4 Gene

    Size:
    753 amino acids
    Molecular mass:
    80596 Da
    Quaternary structure:
    • Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN4. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity). Interacts with CTTNBP2NL.
    Miscellaneous:
    • The name Zinedin probably originates from the name of the famous soccer player from Marseille (Zinedine Zidane).

    Alternative splice isoforms for STRN4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRN4 Gene

Post-translational modifications for STRN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STRN4 Gene

Domains & Families for STRN4 Gene

Suggested Antigen Peptide Sequences for STRN4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRL3

UniProtKB/Swiss-Prot:

STRN4_HUMAN :
  • Belongs to the WD repeat striatin family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat striatin family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with STRN4: view

Function for STRN4 Gene

Molecular function for STRN4 Gene

UniProtKB/Swiss-Prot Function:
Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

Gene Ontology (GO) - Molecular Function for STRN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
GO:0005516 calmodulin binding NAS 10748158
GO:0019904 protein domain specific binding IEA --
GO:0032403 protein complex binding IDA 18782753
GO:0051721 protein phosphatase 2A binding IDA 18782753
genes like me logo Genes that share ontologies with STRN4: view
genes like me logo Genes that share phenotypes with STRN4: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STRN4 Gene

Localization for STRN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRN4 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, dendritic spine. Note=CTTNBP2-binding may regulate dendritic spine distribution. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STRN4 Gene COMPARTMENTS Subcellular localization image for STRN4 gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for STRN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 colocalizes_with protein phosphatase type 2A complex IDA 18782753
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0042995 cell projection IEA --
GO:0043197 dendritic spine IEA --
genes like me logo Genes that share ontologies with STRN4: view

Pathways & Interactions for STRN4 Gene

SuperPathways for STRN4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STRN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with STRN4: view

No data available for Pathways by source and SIGNOR curated interactions for STRN4 Gene

Drugs & Compounds for STRN4 Gene

(1) Drugs for STRN4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with STRN4: view

Transcripts for STRN4 Gene

Unigene Clusters for STRN4 Gene

Striatin, calmodulin binding protein 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRN4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3:
SP4: - - - - - -
SP5: - - -
SP6: - - - - - - - - -
SP7: -
SP8: - -
SP9: - - - -
SP10: - - -
SP11: - - -
SP12:
SP13: - -
SP14: -

ExUns: 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for STRN4 Gene

GeneLoc Exon Structure for
STRN4
ECgene alternative splicing isoforms for
STRN4

Expression for STRN4 Gene

mRNA expression in normal human tissues for STRN4 Gene

Protein differential expression in normal tissues from HIPED for STRN4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STRN4 Gene



Protein tissue co-expression partners for STRN4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STRN4 Gene:

STRN4

SOURCE GeneReport for Unigene cluster for STRN4 Gene:

Hs.631590
genes like me logo Genes that share expression patterns with STRN4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STRN4 Gene

Orthologs for STRN4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRN4 34 35
  • 97.29 (n)
dog
(Canis familiaris)
Mammalia STRN4 34 35
  • 89.94 (n)
cow
(Bos Taurus)
Mammalia STRN4 34 35
  • 88.26 (n)
mouse
(Mus musculus)
Mammalia Strn4 34 16 35
  • 87.78 (n)
rat
(Rattus norvegicus)
Mammalia Strn4 34
  • 87.68 (n)
oppossum
(Monodelphis domestica)
Mammalia STRN4 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRN4 35
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRN4 35
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii strn4 34 35 35
  • 65.25 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COP1 35
  • 8 (a)
OneToMany
Species where no ortholog for STRN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STRN4 Gene

ENSEMBL:
Gene Tree for STRN4 (if available)
TreeFam:
Gene Tree for STRN4 (if available)

Paralogs for STRN4 Gene

Paralogs for STRN4 Gene

genes like me logo Genes that share paralogs with STRN4: view

Variants for STRN4 Gene

Sequence variations from dbSNP and Humsavar for STRN4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401422 -- 46,741,273(+) GGGGG(A/C)AGGAG intron-variant, upstream-variant-2KB
rs10402664 -- 46,722,496(+) GCGCT(A/G)GTTCT intron-variant
rs10409124 -- 46,723,177(+) GCGGA(C/T)GGTGC reference, missense, utr-variant-3-prime
rs10411851 -- 46,726,856(+) CACTG(C/T)ACTTC intron-variant
rs10414958 -- 46,734,078(+) ATCCT(A/G)TGCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STRN4 Gene

Variant ID Type Subtype PubMed ID
nsv833850 CNV loss 17160897
nsv953590 CNV deletion 24416366

Variation tolerance for STRN4 Gene

Residual Variation Intolerance Score: 6.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STRN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STRN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRN4 Gene

Disorders for STRN4 Gene

Relevant External Links for STRN4

Genetic Association Database (GAD)
STRN4
Human Genome Epidemiology (HuGE) Navigator
STRN4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STRN4

No disorders were found for STRN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STRN4 Gene

Publications for STRN4 Gene

  1. Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. (PMID: 10748158) Castets F. … Monneron A. (J. Biol. Chem. 2000) 2 3 4 64
  2. Genetic susceptibility variants for chronic lymphocytic leukemia. (PMID: 20332261) Slager S.L. … Cerhan J.R. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M. … Gingras A.C. (Mol. Cell. Proteomics 2009) 3 4 64
  5. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. (PMID: 18758461) Di Bernardo M.C. … Houlston R.S. (Nat. Genet. 2008) 3 46 64

Products for STRN4 Gene

Sources for STRN4 Gene

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