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Aliases for STRN4 Gene

Aliases for STRN4 Gene

  • Striatin, Calmodulin Binding Protein 4 2 3
  • ZIN 3 4 6
  • Zinedin 3 4
  • Striatin-4 3

External Ids for STRN4 Gene

Previous GeneCards Identifiers for STRN4 Gene

  • GC19M047614
  • GC19M051898
  • GC19M051914
  • GC19M047222
  • GC19M043647

Summaries for STRN4 Gene

GeneCards Summary for STRN4 Gene

STRN4 (Striatin, Calmodulin Binding Protein 4) is a Protein Coding gene. GO annotations related to this gene include calmodulin binding and protein phosphatase 2A binding. An important paralog of this gene is STRN.

UniProtKB/Swiss-Prot for STRN4 Gene

  • Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein

Gene Wiki entry for STRN4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRN4 Gene

Genomics for STRN4 Gene

Regulatory Elements for STRN4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STRN4 Gene

46,719,507 bp from pter
46,746,994 bp from pter
27,488 bases
Minus strand

Genomic View for STRN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STRN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRN4 Gene

Proteins for STRN4 Gene

  • Protein details for STRN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A0A024R0V2
    • B4DQH7
    • F8VYA6
    • Q8NE53

    Protein attributes for STRN4 Gene

    753 amino acids
    Molecular mass:
    80596 Da
    Quaternary structure:
    • Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN4. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity). Interacts with CTTNBP2NL.
    • The name Zinedin probably originates from the name of the famous soccer player from Marseille (Zinedine Zidane)

    Alternative splice isoforms for STRN4 Gene


neXtProt entry for STRN4 Gene

Proteomics data for STRN4 Gene at MOPED

Post-translational modifications for STRN4 Gene

  • Ubiquitination at Lys431
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STRN4 Gene

Domains for STRN4 Gene

Gene Families for STRN4 Gene

  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for STRN4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9NRL3
  • Belongs to the WD repeat striatin family.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with STRN4: view

Function for STRN4 Gene

Molecular function for STRN4 Gene

UniProtKB/Swiss-Prot Function:
Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein

Gene Ontology (GO) - Molecular Function for STRN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
GO:0005516 calmodulin binding NAS 10748158
GO:0019904 protein domain specific binding --
GO:0032403 protein complex binding IDA 18782753
GO:0051721 protein phosphatase 2A binding IDA 18782753
genes like me logo Genes that share ontologies with STRN4: view

Animal Model Products

miRNA for STRN4 Gene

miRTarBase miRNAs that target STRN4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STRN4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for STRN4 Gene

Localization for STRN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRN4 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, dendritic spine. Note=CTTNBP2-binding may regulate dendritic spine distribution. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for STRN4 Gene COMPARTMENTS Subcellular localization image for STRN4 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for STRN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 colocalizes_with protein phosphatase type 2A complex IDA 18782753
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0042995 cell projection --
GO:0043197 dendritic spine IEA --
genes like me logo Genes that share ontologies with STRN4: view

Pathways for STRN4 Gene

SuperPathways for STRN4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STRN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with STRN4: view

No data available for Pathways by source for STRN4 Gene

Compounds for STRN4 Gene

(1) HMDB Compounds for STRN4 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with STRN4: view

Transcripts for STRN4 Gene

Unigene Clusters for STRN4 Gene

Striatin, calmodulin binding protein 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STRN4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRN4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - - - - - - -
SP7: -
SP8: - -
SP9: - - - -
SP10: - - -
SP11: - - -
SP13: - -
SP14: -

ExUns: 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23
SP1: -
SP2: -
SP7: -
SP8: -

Relevant External Links for STRN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STRN4 Gene

mRNA expression in normal human tissues for STRN4 Gene

Protein differential expression in normal tissues for STRN4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STRN4 Gene

SOURCE GeneReport for Unigene cluster for STRN4 Gene Hs.631590

genes like me logo Genes that share expressions with STRN4: view

Expression partners for STRN4 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STRN4 Gene

Orthologs for STRN4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STRN4 35
  • 88.26 (n)
  • 92.68 (a)
STRN4 36
  • 88 (a)
(Canis familiaris)
Mammalia STRN4 35
  • 89.94 (n)
  • 95.61 (a)
STRN4 36
  • 96 (a)
(Mus musculus)
Mammalia Strn4 35
  • 87.78 (n)
  • 95.09 (a)
Strn4 16
Strn4 36
  • 95 (a)
(Pan troglodytes)
Mammalia STRN4 35
  • 97.29 (n)
  • 97.07 (a)
STRN4 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Strn4 35
  • 87.68 (n)
  • 94.68 (a)
(Monodelphis domestica)
Mammalia STRN4 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia STRN4 36
  • 78 (a)
(Anolis carolinensis)
Reptilia STRN4 36
  • 77 (a)
(Danio rerio)
Actinopterygii strn4 35
  • 65.25 (n)
  • 65.2 (a)
strn4 36
  • 58 (a)
strn4 36
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COP1 36
  • 8 (a)
Species with no ortholog for STRN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STRN4 Gene

Gene Tree for STRN4 (if available)
Gene Tree for STRN4 (if available)

Paralogs for STRN4 Gene

Paralogs for STRN4 Gene

genes like me logo Genes that share paralogs with STRN4: view

Variants for STRN4 Gene

Sequence variations from dbSNP and Humsavar for STRN4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs160544 -- 46,731,628(+) CGGCT(A/G)CCATC intron-variant
rs167520 -- 46,736,707(+) GCTAA(A/G)ATCCT intron-variant
rs184341 -- 46,737,960(+) CAAGC(A/G)GGACT intron-variant
rs186379 -- 46,736,650(+) TCCCT(C/T)TCCCC intron-variant
rs313840 -- 46,720,286(-) TTGCC(A/G)TGGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for STRN4 Gene

Variant ID Type Subtype PubMed ID
dgv3961n71 CNV Loss 21882294
nsv912189 CNV Loss 21882294
nsv833850 CNV Loss 17160897

Relevant External Links for STRN4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRN4 Gene

Disorders for STRN4 Gene

Relevant External Links for STRN4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for STRN4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for STRN4 Gene

Publications for STRN4 Gene

  1. Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. (PMID: 10748158) Castets F. … Monneron A. (J. Biol. Chem. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. (PMID: 18758461) Di Bernardo M.C. … Houlston R.S. (Nat. Genet. 2008) 3 48
  5. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M. … Gingras A.C. (Mol. Cell. Proteomics 2009) 3 4

Products for STRN4 Gene

Sources for STRN4 Gene

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