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Aliases for STRN3 Gene

Aliases for STRN3 Gene

  • Striatin 3 2 3 5
  • Striatin, Calmodulin Binding Protein 3 2 3
  • Cell Cycle S/G2 Nuclear Autoantigen 2 3
  • Cell Cycle Autoantigen SG2NA 3 4
  • S/G2 Antigen 3 4
  • SG2NA 3 4
  • Nuclear Autoantigen 3
  • GS2NA 4

External Ids for STRN3 Gene

Previous GeneCards Identifiers for STRN3 Gene

  • GC14M028738
  • GC14M025150
  • GC14M029353
  • GC14M030432
  • GC14M031363
  • GC14M011480

Summaries for STRN3 Gene

GeneCards Summary for STRN3 Gene

STRN3 (Striatin 3) is a Protein Coding gene. Among its related pathways are DAG and IP3 signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and calmodulin binding. An important paralog of this gene is STRN.

UniProtKB/Swiss-Prot for STRN3 Gene

  • Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

Gene Wiki entry for STRN3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRN3 Gene

Genomics for STRN3 Gene

Regulatory Elements for STRN3 Gene

Promoters for STRN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STRN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for STRN3 Gene

Chromosome:
14
Start:
30,893,779 bp from pter
End:
31,026,528 bp from pter
Size:
132,750 bases
Orientation:
Minus strand

Genomic View for STRN3 Gene

Genes around STRN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRN3 Gene

Proteins for STRN3 Gene

  • Protein details for STRN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13033-STRN3_HUMAN
    Recommended name:
    Striatin-3
    Protein Accession:
    Q13033
    Secondary Accessions:
    • A2RTX7
    • A6NHZ7
    • Q9NRA5

    Protein attributes for STRN3 Gene

    Size:
    797 amino acids
    Molecular mass:
    87209 Da
    Quaternary structure:
    • Interacts with protein phosphatase 2A (PP2A). Interacts with CDC42BPB (PubMed:25743393).

    Three dimensional structures from OCA and Proteopedia for STRN3 Gene

    Alternative splice isoforms for STRN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRN3 Gene

Proteomics data for STRN3 Gene at MOPED

Post-translational modifications for STRN3 Gene

  • Ubiquitination at Lys 173
  • Modification sites at PhosphoSitePlus

Other Protein References for STRN3 Gene

Antibody Products

No data available for DME Specific Peptides for STRN3 Gene

Domains & Families for STRN3 Gene

Suggested Antigen Peptide Sequences for STRN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q13033

UniProtKB/Swiss-Prot:

STRN3_HUMAN :
  • Belongs to the WD repeat striatin family.
  • Contains 6 WD repeats.
Family:
  • Belongs to the WD repeat striatin family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with STRN3: view

Function for STRN3 Gene

Molecular function for STRN3 Gene

UniProtKB/Swiss-Prot Function:
Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

Gene Ontology (GO) - Molecular Function for STRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 18782753
GO:0032403 protein complex binding IEA,IDA 18782753
GO:0051721 protein phosphatase 2A binding IDA 18782753
genes like me logo Genes that share ontologies with STRN3: view
genes like me logo Genes that share phenotypes with STRN3: view

Animal Models for STRN3 Gene

MGI Knock Outs for STRN3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STRN3 Gene

Localization for STRN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRN3 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STRN3 Gene COMPARTMENTS Subcellular localization image for STRN3 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for STRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 colocalizes_with protein phosphatase type 2A complex IDA 18782753
GO:0005634 nucleus IDA 18434427
GO:0005737 cytoplasm IEA,IDA 18434427
GO:0005886 plasma membrane IDA 11251078
GO:0030425 dendrite IEA,ISS --
genes like me logo Genes that share ontologies with STRN3: view

Pathways & Interactions for STRN3 Gene

genes like me logo Genes that share pathways with STRN3: view

Pathways by source for STRN3 Gene

Gene Ontology (GO) - Biological Process for STRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032355 response to estradiol IEA,ISS --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with STRN3: view

No data available for SIGNOR curated interactions for STRN3 Gene

Drugs & Compounds for STRN3 Gene

(1) Drugs for STRN3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with STRN3: view

Transcripts for STRN3 Gene

Unigene Clusters for STRN3 Gene

Striatin, calmodulin binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STRN3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2:
SP3: - - -

Relevant External Links for STRN3 Gene

GeneLoc Exon Structure for
STRN3
ECgene alternative splicing isoforms for
STRN3

Expression for STRN3 Gene

mRNA expression in normal human tissues for STRN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STRN3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for STRN3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.7) and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STRN3 Gene



SOURCE GeneReport for Unigene cluster for STRN3 Gene Hs.401843

genes like me logo Genes that share expression patterns with STRN3: view

Protein tissue co-expression partners for STRN3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for STRN3 Gene

Orthologs for STRN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STRN3 35
  • 95.19 (n)
  • 97.24 (a)
STRN3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STRN3 35
  • 95.07 (n)
  • 97.47 (a)
STRN3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Strn3 35
  • 92.67 (n)
  • 95.73 (a)
Strn3 16
Strn3 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STRN3 35
  • 99.72 (n)
  • 99.43 (a)
STRN3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Strn3 35
  • 92.54 (n)
  • 95.11 (a)
oppossum
(Monodelphis domestica)
Mammalia STRN3 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRN3 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves STRN3 35
  • 89.48 (n)
  • 95.19 (a)
STRN3 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRN3 36
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii strn3 35
strn3 35
  • 72.21 (n)
  • 76.25 (a)
strn3 36
  • 80 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9790 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008755 35
  • 57.79 (n)
  • 64.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cka 35
  • 56.51 (n)
  • 59.19 (a)
worm
(Caenorhabditis elegans)
Secernentea cash-1 35
  • 54.33 (n)
  • 46.19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COP1 36
  • 10 (a)
OneToMany
FAR8 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3348 35
Species with no ortholog for STRN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for STRN3 Gene

ENSEMBL:
Gene Tree for STRN3 (if available)
TreeFam:
Gene Tree for STRN3 (if available)

Paralogs for STRN3 Gene

Paralogs for STRN3 Gene

(4) SIMAP similar genes for STRN3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with STRN3: view

Variants for STRN3 Gene

Sequence variations from dbSNP and Humsavar for STRN3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2273171 - 30,912,145(+) TGGGA(C/T)TCCAT reference, missense, utr-variant-3-prime
rs766146 -- 30,906,116(-) ATTGA(A/T)CTGGC intron-variant
rs179696 -- 31,000,501(+) CAAGT(A/C)ACTGC intron-variant
rs179697 -- 31,000,985(+) ATAGG(A/G)TTCTA intron-variant
rs179699 -- 31,001,393(+) ttgcc(A/G)ggcat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STRN3 Gene

Variant ID Type Subtype PubMed ID
esv33189 CNV Loss 17666407
nsv901581 CNV Gain 21882294
nsv832762 CNV Loss 17160897
nsv901584 CNV Loss 21882294
nsv901585 CNV Loss 21882294
nsv901586 CNV Loss 21882294
nsv456197 CNV Loss 19166990
nsv85534 CNV Loss 16902084
nsv1231 CNV Loss 18451855
esv270846 CNV Insertion 20981092
esv273676 CNV Insertion 20981092
esv2659815 CNV Deletion 23128226
nsv1233 CNV Insertion 18451855

Variation tolerance for STRN3 Gene

Residual Variation Intolerance Score: 4.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.93; 96.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STRN3 Gene

HapMap Linkage Disequilibrium report
STRN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRN3 Gene

Disorders for STRN3 Gene

Relevant External Links for STRN3

Genetic Association Database (GAD)
STRN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STRN3

No disorders were found for STRN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STRN3 Gene

Publications for STRN3 Gene

  1. A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells. (PMID: 7864889) Muro Y. … Tan E.M. (Biochem. Biophys. Res. Commun. 1995) 2 3 4 23 67
  2. Striatin-3 gamma inhibits estrogen receptor activity by recruiting a protein phosphatase. (PMID: 18434427) Tan B. … Bigsby R.M. (J. Mol. Endocrinol. 2008) 3 23
  3. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. (PMID: 10681496) Moreno C.S. … Pallas D.C. (J. Biol. Chem. 2000) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for STRN3 Gene

Sources for STRN3 Gene

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