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STRN3 Gene

protein-coding   GIFtS: 61
GCID: GC14M031363

Striatin, Calmodulin Binding Protein 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Striatin, Calmodulin Binding Protein 31 2     S/G2 Antigen2 3
SG2NA2 3 5     Nuclear Autoantigen2
Cell Cycle S/G2 Nuclear Autoantigen1 2     striatin-32
Cell Cycle Autoantigen SG2NA2 3     GS2NA3

External Ids:    HGNC: 157201   Entrez Gene: 299662   Ensembl: ENSG000001967927   OMIM: 6147665   UniProtKB: Q130333   

Export aliases for STRN3 gene to outside databases

Previous GC identifers: GC14M028738 GC14M025150 GC14M029353 GC14M030432 GC14M011480


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STRN3 Gene:
STRN3 (striatin, calmodulin binding protein 3) is a protein-coding gene. GO annotations related to this gene include protein complex binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is STRN.

UniProtKB/Swiss-Prot: STRN3_HUMAN, Q13033
Function: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein

Gene Wiki entry for STRN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STRN3 gene promoter:
         AhR   Lmo2   Cdc5   Meis-1b   E47   CREB   deltaCREB   Chx10   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTRN3 promoter sequence
   Search Chromatin IP Primers for STRN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STRN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13-q21   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q13-q21

STRN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STRN3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M031363:  view genomic region     (about GC identifiers)

Start:
31,363,005 bp from pter      End:
31,495,607 bp from pter
Size:
132,603 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STRN3_HUMAN, Q13033 (See protein sequence)
Recommended Name: Striatin-3  
Size: 797 amino acids; 87209 Da
Subunit: Interacts with protein phosphatase 2A (PP2A) (Potential)
Caution: Was originally (PubMed:7864889) thought to be nuclear
Secondary accessions: A2RTX7 A6NHZ7 Q9NRA5
Alternative splicing: 2 isoforms:  Q13033-1   Q13033-2   

Explore the universe of human proteins at neXtProt for STRN3: NX_Q13033

Explore proteomics data for STRN3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys173
  • Modification sites at PhosphoSitePlus

  • See STRN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001077362.1  NP_055389.3  

    ENSEMBL proteins: 
     ENSP00000347909   ENSP00000350071   ENSP00000451028   ENSP00000452542   ENSP00000452092  
     ENSP00000451233  

    STRN3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for STRN3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for STRN3
    GenScript Custom Purified and Recombinant Proteins Services for STRN3
    Novus Biologicals STRN3 Protein
    Novus Biologicals STRN3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STRN3

     
    Search eBioscience for Proteins for STRN3 

    STRN3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of STRN3
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    ThermoFisher Antibody for STRN3
    LSBio Antibodies in human, mouse, rat for STRN3

    STRN3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STRN3
    Cloud-Clone Corp. CLIAs for STRN3
    Search eBioscience for ELISAs for STRN3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR013258 Striatin_N

    Graphical View of Domain Structure for InterPro Entry Q13033

    ProtoNet protein and cluster: Q13033

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: STRN3_HUMAN, Q13033
    Similarity: Belongs to the WD repeat striatin family
    Similarity: Contains 6 WD repeats


    Find genes that share domains with STRN3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STRN3_HUMAN, Q13033
    Function: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IDA11570823
    GO:0005515protein binding IPI18782753
    GO:0005516calmodulin binding NAS10748158
    GO:0032403protein complex binding IDA18782753
    GO:0051721protein phosphatase 2A binding IDA18782753
         
    Find genes that share ontologies with STRN3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STRN3:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Strn3 (no phenotypes)

    Find genes that share phenotypes with STRN3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STRN3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STRN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STRN3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STRN3

    miRNA
    Products:
        
    miRTarBase miRNAs that target STRN3:
    hsa-mir-125b-5p (MIRT045977)

    Block miRNA regulation of human, mouse, rat STRN3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STRN3 (see all 85):
    hsa-miR-323-3p hsa-miR-376b hsa-miR-4272 hsa-miR-1245 hsa-miR-550a* hsa-miR-3161 hsa-miR-4325 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidSTRN3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STRN3
    Predesigned siRNA for gene silencing in human, mouse, rat STRN3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STRN3

    Clone
    Products:
         
    OriGene clones in human, mouse for STRN3 (see all 13)
    OriGene ORF clones in mouse, rat for STRN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): STRN3 (NM_014574)
    Sino Biological Human cDNA Clone for STRN3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRN3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for STRN3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRN3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STRN3_HUMAN, Q13033: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus5
    plasma membrane5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159colocalizes with protein phosphatase type 2A complex IDA18782753
    GO:0005634nucleus IDA18434427
    GO:0005654nucleoplasm IDA11570823
    GO:0005737cytoplasm IDA18434427
    GO:0005794Golgi apparatus IDA11251078

    Find genes that share ontologies with STRN3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STRN3 About    
    See pathways by source

    SuperPathContained pathways About
    1Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for STRN3
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STRN3
    Interactions:

        Search GeneGlobe Interaction Network for STRN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STRN3 (Q130331, 3 ENSP000003500714) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTTNBP2NLQ9P2B41, 3, ENSP000002712774EBI-1053857,EBI-1774273 I2D: score=2 STRING: ENSP00000271277
    STRNO438151, 3, ENSP000002639184EBI-1053857,EBI-1046642 I2D: score=2 STRING: ENSP00000263918
    TRAF3IP3Q9Y2281, 3, ENSP000000103384EBI-1053857,EBI-765817 I2D: score=2 STRING: ENSP00000010338
    CALM1P621583, ENSP000003494674I2D: score=2 STRING: ENSP00000349467
    CALM2P621583I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA11570823
    GO:0032355response to estradiol ISS--
    GO:0033147negative regulation of intracellular estrogen receptor signaling pathway ISS--
    GO:0045892negative regulation of transcription, DNA-templated IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA11570823

    Find genes that share ontologies with STRN3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STRN3

    1 HMDB Compound for STRN3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STRN3 gene (2 alternative transcripts): 
    NM_001083893.1  NM_014574.3  

    Unigene Cluster for STRN3:

    Striatin, calmodulin binding protein 3
    Hs.401843  [show with all ESTs]
    Unigene Representative Sequence: NM_001083893
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355683(uc001wqu.2 uc001wqv.2 uc010tpj.1) ENST00000357479
    ENST00000555358 ENST00000554124 ENST00000366206 ENST00000554991 ENST00000556577
    ENST00000555152
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STRN3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STRN3 (see all 85):
    hsa-miR-323-3p hsa-miR-376b hsa-miR-4272 hsa-miR-1245 hsa-miR-550a* hsa-miR-3161 hsa-miR-4325 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidSTRN3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STRN3
    Clone
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    OriGene ORF clones in mouse, rat for STRN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): STRN3 (NM_014574)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRN3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for STRN3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STRN3
      QuantiTect SYBR Green Assays in human, mouse, rat STRN3
      QuantiFast Probe-based Assays in human, mouse, rat STRN3

    Additional mRNA sequence: 

    AF243424.1 AK290229.1 AK314041.1 BC126221.1 BC132673.1 BC143933.1 U17989.1 

    11 DOTS entries:

    DT.92425863  DT.99937247  DT.100732556  DT.92425859  DT.312608  DT.120794873  DT.100742031  DT.91647665 
    DT.100733184  DT.100766885  DT.92425860 

    Selected AceView cDNA sequences (see all 83):

    AA769156 BE770192 BM453981 BM129111 BG429846 AA287463 BM703040 CA944831 
    NM_014574 BM983887 CB113023 AA358216 BQ637249 AF243424 BQ776020 AW104574 
    U17989 AI696581 CB215669 AW243088 BX367743 BM801266 BX501053 BX369751 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for STRN3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                  -                                                   
    SP2:                                                                                                      
    SP3:                                -     -           -                                                   


    ECgene alternative splicing isoforms for STRN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STRN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    STRN3 Expression
    About this image


    STRN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone marrow-derived hematopoietic stem cells (family)
    STRN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STRN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.401843
        Custom PCR Arrays for STRN3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for STRN3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STRN3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STRN3 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Strn31 , 5 striatin, calmodulin binding protein 31, 5 92.67(n)1
    95.73(a)1
      12 (22.11 cM)5
    941861  NM_052973.21  NP_443205.11 
     516085415 
    chicken
    (Gallus gallus)
    Aves STRN31 striatin, calmodulin binding protein 3 89.48(n)
    95.19(a)
      423308  XM_004941748.1  XP_004941805.1 
    lizard
    (Anolis carolinensis)
    Reptilia STRN36
    striatin, calmodulin binding protein 3
    89(a)
    1 ↔ 1
    2(57002907-57051527)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480200422   -- 79.29(n)    48020042 
    zebrafish
    (Danio rerio)
    Actinopterygii strn32 striatin, calmodulin binding protein 3 76.89(n)   368853  57061972 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cka1 Connector of kinase to AP-1 56.51(n)
    59.19(a)
      34096  NM_001273292.1  NP_001260221.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cash-11 cash-1 54.33(n)
    46.19(a)
      179445  NM_073263.4  NP_505664.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAR8(YMR029C)4 Protein involved in recovery from cell cycle arrest more   --   13(330231-328660) 855044  NP_013742.1 
    soybean
    (Glycine max)
    eudicotyledons CD416082.12   -- 71.16(n)    CD416082.1 


    ENSEMBL Gene Tree for STRN3 (if available)
    TreeFam Gene Tree for STRN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STRN3 gene
    STRN2  COPA2  STRN42  
    4 SIMAP similar genes for STRN3 using alignment to 6 protein entries:     STRN3_HUMAN (see all proteins):
    LOC729862    STRN    STRN4    WSB1

    Find genes that share paralogs with STRN3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STRN3 (see all 2600)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs576445681,2
    C--12434207(+) AAAAA-/AA/AAA
            
    CAACA
    2 -- int11NA 2
    rs1896151821,2
    --31362509(+) CACCAC/TGCCCG 2 -- ds50010--------
    rs128971081,2
    C,F,A--31362510(+) accacT/Gcccgg 2 -- ds50013Minor allele frequency- G:0.33NA 6
    rs1428804881,2
    --31362519(+) GGCTAA/GTTTTG 2 -- ds50010--------
    rs1825935281,2
    --31362534(+) TGTGTG/TTTTTT 2 -- ds50010--------
    rs1510864851,2
    --31362541(+) TTTTAA/GTAGAG 2 -- ds50010--------
    rs1854144041,2
    --31362613(+) TCGGCC/TTCCCA 2 -- ds50010--------
    rs1906178351,2
    --31362722(+) CTGAAC/TTTTTT 2 -- ds50010--------
    rs287257691,2
    C,F--31362787(+) TTAATA/TATGTA 2 -- ds50011Minor allele frequency- T:0.11WA 118
    rs752192041,2
    C,F--31362824(+) AACTGC/TACCTG 2 -- ds50012Minor allele frequency- T:0.12WA EA 238

    HapMap Linkage Disequilibrium report for STRN3 (31363005 - 31495607 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STRN3 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659815CNV Deletion23128226
    esv273676CNV Insertion20981092
    nsv1233CNV Insertion18451855
    esv270846CNV Insertion20981092
    nsv456197CNV Loss19166990
    nsv901584CNV Loss21882294
    nsv901585CNV Loss21882294
    nsv832762CNV Loss17160897
    nsv901586CNV Loss21882294
    nsv85534CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614766    OMIM disorders: --


    Find genes that share disorders with STRN3           About GenesLikeMe

    Genetic Association Database (GAD): STRN3

    Export disorders for STRN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STRN3 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with STRN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells. (PubMed id 7864889)1, 2, 3, 9 Muro Y.... Tan E.M. (Biochem. Biophys. Res. Commun. 1995)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    3. Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. (PubMed id 10748158)1, 2 Castets F....Monneron A. (J. Biol. Chem. 2000)
    4. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. (PubMed id 10681496)1, 3 Moreno C.S....Pallas D.C. (J. Biol. Chem. 2000)
    5. Striatin-3 gamma inhibits estrogen receptor activity by recruiting a protein phosphatase. (PubMed id 18434427)1, 9 Tan B....Bigsby R.M. (J. Mol. Endocrinol. 2008)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction. (PubMed id 23277359)1 Tran H....Polakis P. (J. Biol. Chem. 2013)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. Three new single nucleotide polymorphisms identified by a genome-wide association study in Korean patients with vitiligo. (PubMed id 23678272)1 Cheong K.A....Lee A.Y. (J. Korean Med. Sci. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29966 HGNC: 15720 AceView: STRN3 Ensembl:ENSG00000196792 euGenes: HUgn29966
    ECgene: STRN3 H-InvDB: STRN3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STRN3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STRN3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STRN3 gene:
    Search GeneIP for patents involving STRN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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