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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STRN3 Gene

protein-coding   GIFtS: 59
GCID: GC14M031363

Striatin, Calmodulin Binding Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Striatin, Calmodulin Binding Protein 31 2     SG2NA2 3
Cell Cycle S/G2 Nuclear Autoantigen1 2     Nuclear Autoantigen2
Cell Cycle Autoantigen SG2NA2 3     striatin-32
S/G2 Antigen2 3     GS2NA3

External Ids:    HGNC: 157201   Entrez Gene: 299662   Ensembl: ENSG000001967927   OMIM: 6147665   UniProtKB: Q130333   

Export aliases for STRN3 gene to outside databases

Previous GC identifers: GC14M028738 GC14M025150 GC14M029353 GC14M030432 GC14M011480


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for STRN3 Gene: 
STRN3 (striatin, calmodulin binding protein 3) is a protein-coding gene. Diseases associated with STRN3 include cerebral cavernous malformations 3, and cavernous malformation, and among its related super-pathways are Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling. GO annotations related to this gene include protein complex binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is STRN.

UniProtKB/Swiss-Prot: STRN3_HUMAN, Q13033
Function: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein

Gene Wiki entry for STRN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STRN3 gene promoter:
         AhR   Lmo2   Cdc5   Meis-1b   E47   CREB   deltaCREB   Chx10   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTRN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for STRN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STRN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13-q21   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q13-q21

STRN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STRN3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M031363:  view genomic region     (about GC identifiers)

Start:
31,363,005 bp from pter      End:
31,495,607 bp from pter
Size:
132,603 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STRN3_HUMAN, Q13033 (See protein sequence)
Recommended Name: Striatin-3  
Size: 797 amino acids; 87209 Da
Subunit: Interacts with protein phosphatase 2A (PP2A) (Potential)
Subcellular location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
Caution: Was originally (PubMed:7864889) thought to be nuclear
Secondary accessions: A2RTX7 A6NHZ7 Q9NRA5
Alternative splicing: 2 isoforms:  Q13033-1   Q13033-2   

Explore the universe of human proteins at neXtProt for STRN3: NX_Q13033

Explore proteomics data for STRN3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13033

  • STRN3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STRN3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001077362.1  NP_055389.3  

    ENSEMBL proteins: 
     ENSP00000347909   ENSP00000350071   ENSP00000451028   ENSP00000452542   ENSP00000452092  
     ENSP00000451233  

    Human Recombinant Protein Products for STRN3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for STRN3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for STRN3
    GenScript Custom Purified and Recombinant Proteins Services for STRN3
    Novus Biologicals STRN3 Protein
    Novus Biologicals STRN3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STRN3 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159colocalizes with protein phosphatase type 2A complex IDA18782753
    GO:0005634nucleus IDA18434427
    GO:0005654nucleoplasm IDA11570823
    GO:0005737cytoplasm IDA18434427
    GO:0005794Golgi apparatus IDA11251078

    STRN3 for ontologies           About GeneDecksing



    STRN3 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for STRN3 

    Assay Products for STRN3: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STRN3 
    Cloud-Clone Corp. CLIAs for STRN3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR013258 Striatin_N

    Graphical View of Domain Structure for InterPro Entry Q13033

    ProtoNet protein and cluster: Q13033

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: STRN3_HUMAN, Q13033
    Similarity: Belongs to the WD repeat striatin family
    Similarity: Contains 6 WD repeats


    STRN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STRN3_HUMAN, Q13033
    Function: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IDA11570823
    GO:0005515protein binding IPI18782753
    GO:0005516calmodulin binding NAS10748158
    GO:0032403protein complex binding IDA18782753
    GO:0051721protein phosphatase 2A binding IDA18782753
         
    STRN3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for STRN3:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Strn3 (no phenotypes)

    STRN3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for STRN3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STRN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STRN3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STRN3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STRN3
    8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate STRN3 (see all 85):
    hsa-miR-323-3p hsa-miR-376b hsa-miR-4272 hsa-miR-1245 hsa-miR-550a* hsa-miR-3161 hsa-miR-4325 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidSTRN3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STRN3
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    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for STRN3
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    GenScript: all cDNA clones in your preferred vector (see all 2): STRN3 (NM_014574)
    Sino Biological Human cDNA Clone for STRN3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRN3
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                         Customized lentivirus expression plasmids for stable overexpression of STRN3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRN3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STRN3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling0.98

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for STRN3
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling


    1 GeneGo (Thomson Reuters) Pathway for STRN3
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling




    STRN3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STRN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for STRN3 (Q130331, 3 ENSP000003500714) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTTNBP2NLQ9P2B41, 3, ENSP000002712774EBI-1053857,EBI-1774273 I2D: score=2 STRING: ENSP00000271277
    STRNO438151, 3, ENSP000002639184EBI-1053857,EBI-1046642 I2D: score=2 STRING: ENSP00000263918
    TRAF3IP3Q9Y2281, 3, ENSP000000103384EBI-1053857,EBI-765817 I2D: score=2 STRING: ENSP00000010338
    CALM1P621583, ENSP000003494674I2D: score=2 STRING: ENSP00000349467
    CALM2P621583I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA11570823
    GO:0032355response to estradiol stimulus ISS--
    GO:0033147negative regulation of intracellular estrogen receptor signaling pathway ISS--
    GO:0045892negative regulation of transcription, DNA-dependent IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA11570823

    STRN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STRN3

    1 HMDB Compound for STRN3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about STRN3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STRN3 gene (2 alternative transcripts): 
    NM_001083893.1  NM_014574.3  

    Unigene Cluster for STRN3:

    Striatin, calmodulin binding protein 3
    Hs.401843  [show with all ESTs]
    Unigene Representative Sequence: NM_001083893
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355683(uc001wqu.2 uc001wqv.2 uc010tpj.1) ENST00000357479
    ENST00000555358 ENST00000554124 ENST00000366206 ENST00000554991 ENST00000556577
    ENST00000555152
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STRN3
    8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate STRN3 (see all 85):
    hsa-miR-323-3p hsa-miR-376b hsa-miR-4272 hsa-miR-1245 hsa-miR-550a* hsa-miR-3161 hsa-miR-4325 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidSTRN3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STRN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STRN3
    Sirion Biotech Customized lentivirus for stable overexpression of STRN3 
                         Customized lentivirus expression plasmids for stable overexpression of STRN3 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STRN3

    Additional mRNA sequence: 

    AF243424.1 AK290229.1 AK314041.1 BC126221.1 BC132673.1 BC143933.1 U17989.1 

    11 DOTS entries:

    DT.92425863  DT.99937247  DT.100732556  DT.92425859  DT.312608  DT.120794873  DT.100742031  DT.91647665 
    DT.100733184  DT.100766885  DT.92425860 

    24/83 AceView cDNA sequences (see all 83):

    AA287463 BM129111 CA944831 AA358216 NM_014574 BE770192 CB113023 BM983887 
    BM703040 BG429846 BQ776020 BM453981 AF243424 BQ637249 AA769156 AA069680 
    BX394218 AA308075 BX501053 AW243088 CB147688 AA836616 CB986898 BF055093 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for STRN3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                  -                                                   
    SP2:                                                                                                      
    SP3:                                -     -           -                                                   


    ECgene alternative splicing isoforms for STRN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STRN3 expression in normal human tissues (normalized intensities)      STRN3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    STRN3 Expression
    About this image


    STRN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Uterus (Reproductive System)
             endometrial endothelial cell   
     
     Blood (Hematopoietic System)
             Bone marrow-derived hematopoietic stem cells

    See STRN3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STRN3

    SOURCE GeneReport for Unigene cluster: Hs.401843
        SABiosciences Custom PCR Arrays for STRN3
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STRN3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STRN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STRN3 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Strn31 , 5 striatin, calmodulin binding protein 31, 5 92.88(n)1
    96.11(a)1
      12 (22.11 cM)5
    941861  NM_052973.21  NP_443205.11 
     516085415 
    chicken
    (Gallus gallus)
    Aves STRN31 striatin, calmodulin binding protein 3 88.19(n)
    93.34(a)
      423308  XM_003641400.1  XP_003641448.1 
    lizard
    (Anolis carolinensis)
    Reptilia STRN36
    Uncharacterized protein
    89(a)
    1 ↔ 1
    2(57002907-57051527)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480200422   -- 79.29(n)    48020042 
    zebrafish
    (Danio rerio)
    Actinopterygii strn32 striatin, calmodulin binding protein 3 76.89(n)   368853  57061972 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cka1 Connector of kinase to AP-1 56.25(n)
    57.7(a)
      34096  NM_135333.3  NP_609177.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cash-11 Protein CASH-1 54.56(n)
    46.46(a)
      179445  NM_073263.3  NP_505664.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAR8(YMR029C)4 Protein involved in recovery from cell cycle arrest more   --   13(330231-328660) 855044  NP_013742.1 
    soybean
    (Glycine max)
    eudicotyledons CD416082.12   -- 71.16(n)    CD416082.1 


    ENSEMBL Gene Tree for STRN3 (if available)
    TreeFam Gene Tree for STRN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STRN3 gene
    STRN2  STRN42  
    4 SIMAP similar genes for STRN3 using alignment to 6 protein entries:     STRN3_HUMAN (see all proteins):
    LOC729862    STRN    STRN4    WSB1

    STRN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2600 SNPs in STRN3 are shown (see all 2600)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs576445681,2
    C--12434207(+) AAAAA-/AA/AAA
            
    CAACA
    2 -- int11NA 2
    rs1896151821,2
    --31362509(+) CACCAC/TGCCCG 2 -- ds50010--------
    rs128971081,2
    C,F,A--31362510(+) accacT/Gcccgg 2 -- ds50013Minor allele frequency- G:0.33NA 6
    rs1428804881,2
    --31362519(+) GGCTAA/GTTTTG 2 -- ds50010--------
    rs1825935281,2
    --31362534(+) TGTGTG/TTTTTT 2 -- ds50010--------
    rs1510864851,2
    --31362541(+) TTTTAA/GTAGAG 2 -- ds50010--------
    rs1854144041,2
    --31362613(+) TCGGCC/TTCCCA 2 -- ds50010--------
    rs1906178351,2
    --31362722(+) CTGAAC/TTTTTT 2 -- ds50010--------
    rs287257691,2
    C,F--31362787(+) TTAATA/TATGTA 2 -- ds50011Minor allele frequency- T:0.11WA 118
    rs752192041,2
    C,F--31362824(+) AACTGC/TACCTG 2 -- ds50012Minor allele frequency- T:0.12WA EA 238

    HapMap Linkage Disequilibrium report for STRN3 (31363005 - 31495607 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for STRN3 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2659815CNV Deletion23128226
    esv273676CNV Insertion20981092
    nsv1233CNV Insertion18451855
    esv270846CNV Insertion20981092
    nsv456197CNV Loss19166990
    nsv901584CNV Loss21882294
    nsv901585CNV Loss21882294
    nsv832762CNV Loss17160897
    nsv901586CNV Loss21882294
    nsv85534CNV Loss16902084

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614766    OMIM disorders: --

    5 diseases for STRN3:    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    cerebritis
    neuronitis


    STRN3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): STRN3

    Export disorders for STRN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STRN3 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with STRN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells. (PubMed id 7864889)1, 2, 3, 9 Muro Y.... Tan E.M. (1995)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    3. Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. (PubMed id 10748158)1, 2 Castets F....Monneron A. (2000)
    4. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. (PubMed id 10681496)1, 3 Moreno C.S....Pallas D.C. (2000)
    5. Striatin-3 gamma inhibits estrogen receptor activity by recruiting a protein phosphatase. (PubMed id 18434427)1, 9 Tan B....Bigsby R.M. (2008)
    6. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    7. HectD1 E3 ligase modifies adenomatous polyposis coli ( APC) with polyubiquitin to promote the APC-axin interaction. (PubMed id 23277359)1 Tran H....Polakis P. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29966 HGNC: 15720 AceView: STRN3 Ensembl:ENSG00000196792 euGenes: HUgn29966
    ECgene: STRN3 H-InvDB: STRN3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STRN3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STRN3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STRN3 gene:
    Search GeneIP for patents involving STRN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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