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Aliases for STRN3 Gene

Aliases for STRN3 Gene

  • Striatin, Calmodulin Binding Protein 3 2 3
  • SG2NA 3 4 6
  • Cell Cycle S/G2 Nuclear Autoantigen 2 3
  • Cell Cycle Autoantigen SG2NA 3 4
  • S/G2 Antigen 3 4
  • Nuclear Autoantigen 3
  • Striatin-3 3
  • GS2NA 4

External Ids for STRN3 Gene

Summaries for STRN3 Gene

GeneCards Summary for STRN3 Gene

STRN3 (Striatin, Calmodulin Binding Protein 3) is a Protein Coding gene. Among its related pathways are Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein complex binding. An important paralog of this gene is STRN.

UniProtKB/Swiss-Prot for STRN3 Gene

  • Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein

Gene Wiki entry for STRN3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRN3 Gene

Genomics for STRN3 Gene

Genomic Location for STRN3 Gene

Start:
30,893,779 bp from pter
End:
31,026,401 bp from pter
Size:
132,623 bases
Orientation:
Minus strand

Genomic View for STRN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STRN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRN3 Gene

Regulatory Elements for STRN3 Gene

Proteins for STRN3 Gene

  • Protein details for STRN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13033-STRN3_HUMAN
    Recommended name:
    Striatin-3
    Protein Accession:
    Q13033
    Secondary Accessions:
    • A2RTX7
    • A6NHZ7
    • Q9NRA5

    Protein attributes for STRN3 Gene

    Size:
    797 amino acids
    Molecular mass:
    87209 Da
    Quaternary structure:
    • Interacts with protein phosphatase 2A (PP2A).

    Three dimensional structures from OCA and Proteopedia for STRN3 Gene

    Alternative splice isoforms for STRN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRN3 Gene

Proteomics data for STRN3 Gene at MOPED

Post-translational modifications for STRN3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys173

Other Protein References for STRN3 Gene

No data available for DME Specific Peptides for STRN3 Gene

Domains for STRN3 Gene

Gene Families for STRN3 Gene

HGNC:
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

STRN3_HUMAN
Family:
  • Belongs to the WD repeat striatin family.:
    • Q13033
Similarity:
  • Contains 6 WD repeats.:
    • Q13033
genes like me logo Genes that share domains with STRN3: view

Function for STRN3 Gene

Molecular function for STRN3 Gene

UniProtKB/Swiss-Prot Function: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein

Gene Ontology (GO) - Molecular Function for STRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 11570823
GO:0005515 protein binding IPI 18782753
GO:0005516 calmodulin binding NAS 10748158
GO:0032403 protein complex binding IDA 18782753
GO:0051721 protein phosphatase 2A binding IDA 18782753
genes like me logo Genes that share ontologies with STRN3: view

Phenotypes for STRN3 Gene

GenomeRNAi human phenotypes for STRN3:
genes like me logo Genes that share phenotypes with STRN3: view

miRNA for STRN3 Gene

miRTarBase miRNAs that target STRN3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for STRN3 Gene

Localization for STRN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRN3 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STRN3 Gene COMPARTMENTS Subcellular localization image for STRN3 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for STRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 colocalizes_with protein phosphatase type 2A complex IDA 18782753
GO:0005634 nucleus IDA 18434427
GO:0005654 nucleoplasm IDA 11570823
GO:0005737 cytoplasm IDA 18434427
GO:0005794 Golgi apparatus IDA 11251078
genes like me logo Genes that share ontologies with STRN3: view

Pathways for STRN3 Gene

genes like me logo Genes that share pathways with STRN3: view

Pathways by source for STRN3 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for STRN3 Gene

Gene Ontology (GO) - Biological Process for STRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11570823
GO:0032355 response to estradiol ISS --
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway ISS --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 11570823
genes like me logo Genes that share ontologies with STRN3: view

Compounds for STRN3 Gene

(1) HMDB Compounds for STRN3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with STRN3: view

Transcripts for STRN3 Gene

Unigene Clusters for STRN3 Gene

Striatin, calmodulin binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STRN3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2:
SP3: - - -

Relevant External Links for STRN3 Gene

GeneLoc Exon Structure for
STRN3
ECgene alternative splicing isoforms for
STRN3

Expression for STRN3 Gene

mRNA expression in normal human tissues for STRN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STRN3 Gene

This gene is overexpressed in Muscle - Skeletal (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STRN3 Gene

SOURCE GeneReport for Unigene cluster for STRN3 Gene Hs.401843

genes like me logo Genes that share expressions with STRN3: view

Orthologs for STRN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRN3 36
  • 99.72 (n)
  • 99.43 (a)
STRN3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STRN3 36
  • 95.19 (n)
  • 97.24 (a)
STRN3 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STRN3 36
  • 95.07 (n)
  • 97.47 (a)
STRN3 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Strn3 36
  • 92.67 (n)
  • 95.73 (a)
Strn3 16
Strn3 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STRN3 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRN3 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Strn3 36
  • 92.54 (n)
  • 95.11 (a)
chicken
(Gallus gallus)
Aves STRN3 36
  • 89.48 (n)
  • 95.19 (a)
STRN3 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRN3 37
  • 89 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9790 36
zebrafish
(Danio rerio)
Actinopterygii strn3 36
strn3 36
  • 72.21 (n)
  • 76.25 (a)
strn3 37
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008755 36
  • 57.79 (n)
  • 64.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cka 36
  • 56.51 (n)
  • 59.19 (a)
worm
(Caenorhabditis elegans)
Secernentea cash-1 36
  • 54.33 (n)
  • 46.19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COP1 37
  • 10 (a)
OneToMany
FAR8 39
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3348 36
Species with no ortholog for STRN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for STRN3 Gene

ENSEMBL:
Gene Tree for STRN3 (if available)
TreeFam:
Gene Tree for STRN3 (if available)

Paralogs for STRN3 Gene

Paralogs for STRN3 Gene

Selected SIMAP similar genes for STRN3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with STRN3: view

Variants for STRN3 Gene

Sequence variations from dbSNP and Humsavar for STRN3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs179696 -- 31,000,501(+) CAAGT(A/C)ACTGC intron-variant
rs179697 -- 31,000,985(+) ATAGG(A/G)TTCTA intron-variant
rs179698 -- 31,001,268(+) cagtg(A/G)ctcac intron-variant
rs179699 -- 31,001,393(+) ttgcc(A/G)ggcat intron-variant
rs179700 -- 31,002,189(+) aaaaa(A/C/G)aaggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STRN3 Gene

Variant ID Type Subtype PubMed ID
esv33189 CNV Loss 17666407
nsv901581 CNV Gain 21882294
nsv832762 CNV Loss 17160897
nsv901584 CNV Loss 21882294
nsv901585 CNV Loss 21882294
nsv901586 CNV Loss 21882294
nsv456197 CNV Loss 19166990
nsv85534 CNV Loss 16902084
nsv1231 CNV Loss 18451855
esv270846 CNV Insertion 20981092
esv273676 CNV Insertion 20981092
esv2659815 CNV Deletion 23128226
nsv1233 CNV Insertion 18451855

Relevant External Links for STRN3 Gene

HapMap Linkage Disequilibrium report
STRN3

Disorders for STRN3 Gene

Relevant External Links for STRN3

Genetic Association Database (GAD)
STRN3
genes like me logo Genes that share disorders with STRN3: view

No data available for UniProtKB/Swiss-Prot for STRN3 Gene

Publications for STRN3 Gene

  1. A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells. (PMID: 7864889) Muro Y. … Tan E.M. (Biochem. Biophys. Res. Commun. 1995) 2 3 4 23
  2. Striatin-3 gamma inhibits estrogen receptor activity by recruiting a protein phosphatase. (PMID: 18434427) Tan B. … Bigsby R.M. (J. Mol. Endocrinol. 2008) 3 23
  3. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. (PMID: 10681496) Moreno C.S. … Pallas D.C. (J. Biol. Chem. 2000) 2 3
  4. Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. (PMID: 10748158) Castets F. … Monneron A. (J. Biol. Chem. 2000) 3 4
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4

Products for STRN3 Gene

Sources for STRN3 Gene

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